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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL18 (NCBI Gene ID:6141)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL18
	Gene ID: 6141
	Gene Symbol	RPL18
	Gene ID	6141
	Gene Name	ribosomal protein L18
	Synonyms	DBA18\|L18
	Cytomap	19q13.33
	Type of Gene	protein-coding
	Description	60S ribosomal protein L18large ribosomal subunit protein eL18
	Modification date	20200313
	UniProtAcc	Q07020

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPL18	GO:0002181	cytoplasmic translation	25957688

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL18[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL18	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000549920	49119335	49119459	Frame-shift
ENST00000549920	49119982	49120081	In-frame
ENST00000549920	49120572	49120680	In-frame
ENST00000549920	49121047	49121134	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000549920	49119982	49120081	1021	592	690	188	66	99
ENST00000549920	49120572	49120680	1021	484	591	188	30	66
ENST00000549920	49121047	49121134	1021	397	483	188	1	30

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q07020	1	30	1	1	Initiator methionine	Note=Removed;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12962325;Dbxref=PMID:12962325
Q07020	1	30	2	188	Chain	ID=PRO_0000132769;Note=60S ribosomal protein L18
Q07020	30	66	2	188	Chain	ID=PRO_0000132769;Note=60S ribosomal protein L18
Q07020	66	99	2	188	Chain	ID=PRO_0000132769;Note=60S ribosomal protein L18
Q07020	1	30	1	30	Alternative sequence	ID=VSP_055170;Note=In isoform 2. MGVDIRHNKDRKVRRKEPKSQDIYLRLLVK->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q07020	30	66	1	30	Alternative sequence	ID=VSP_055170;Note=In isoform 2. MGVDIRHNKDRKVRRKEPKSQDIYLRLLVK->M;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q07020	30	66	62	62	Sequence conflict	Note=S->C;Ontology_term=ECO:0000305;evidence=ECO:0000305

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUSC	RPL18	-2.71738134960354	0.000234071565908595
COAD	RPL18	2.06383580378934	0.00144392251968384
KICH	RPL18	-1.4760977092445	0.0173123478889465
KIRC	RPL18	-1.49209569505049	2.49674919862186e-10
KIRP	RPL18	-1.45428676432035	8.19191336631775e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
MESO	RPL18	0.065644651	0.016601885
KIRC	RPL18	-0.043825019	0.035119638

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL18 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	Cell metabolism gene	RPL18	SNRPD2	0.822151443	1.58E-20
CESC	Cell metabolism gene	RPL18	SNRPD2	0.839213086	6.02E-83
CESC	TSG	RPL18	GLTSCR2	0.806265253	9.59E-72
CHOL	Cell metabolism gene	RPL18	PFDN5	0.812662193	1.21E-11
CHOL	Cell metabolism gene	RPL18	SNRPD2	0.832849926	1.29E-12
CHOL	Epifactor	RPL18	FBL	0.813998797	1.05E-11
CHOL	TSG	RPL18	GLTSCR2	0.883845502	8.82E-16
COAD	Cell metabolism gene	RPL18	SNRPD2	0.805387136	2.93E-76
DLBC	Cell metabolism gene	RPL18	ECHS1	0.805343145	5.15E-12
DLBC	Cell metabolism gene	RPL18	PSMC5	0.80756914	4.05E-12
DLBC	Cell metabolism gene	RPL18	PPP2R1A	0.812399563	2.39E-12
DLBC	Cell metabolism gene	RPL18	TOMM22	0.814676451	1.85E-12
DLBC	Cell metabolism gene	RPL18	PSMB3	0.815062832	1.77E-12
DLBC	Cell metabolism gene	RPL18	GFER	0.821850969	8.11E-13
DLBC	Cell metabolism gene	RPL18	TIMM13	0.824551287	5.89E-13
DLBC	Cell metabolism gene	RPL18	PGLS	0.834037797	1.83E-13
DLBC	Cell metabolism gene	RPL18	GEMIN7	0.844262716	4.75E-14
DLBC	Cell metabolism gene	RPL18	NME2	0.852745307	1.44E-14
DLBC	Cell metabolism gene	RPL18	TIMM9	0.852977396	1.40E-14
DLBC	Cell metabolism gene	RPL18	PFDN5	0.884292134	8.03E-17
DLBC	Cell metabolism gene	RPL18	FAU	0.891012666	2.19E-17
DLBC	Cell metabolism gene	RPL18	SNRPD2	0.89280667	1.52E-17
DLBC	CGC	RPL18	NTHL1	0.806106382	4.74E-12
DLBC	CGC	RPL18	PPP2R1A	0.812399563	2.39E-12
DLBC	CGC	RPL18	MAP2K2	0.81445681	1.90E-12
DLBC	CGC	RPL18	NACA	0.857601158	7.05E-15
DLBC	Epifactor	RPL18	PRPF31	0.821151362	8.80E-13
DLBC	Epifactor	RPL18	FBL	0.859276175	5.47E-15
DLBC	IUPHAR	RPL18	MAP2K2	0.81445681	1.90E-12
DLBC	Kinase	RPL18	MAP2K2	0.81445681	1.90E-12
DLBC	TF	RPL18	IRF3	0.818529383	1.19E-12
DLBC	TF	RPL18	ZNF444	0.822224883	7.76E-13
DLBC	TF	RPL18	THAP3	0.82491771	5.63E-13
DLBC	TF	RPL18	ZNF581	0.842385618	6.13E-14
DLBC	TF	RPL18	THAP7	0.844943884	4.33E-14
DLBC	TF	RPL18	NME2	0.852745307	1.44E-14
DLBC	TSG	RPL18	IRF3	0.818529383	1.19E-12
DLBC	TSG	RPL18	GADD45GIP1	0.848508429	2.64E-14
DLBC	TSG	RPL18	GLTSCR2	0.905128228	1.05E-18
DLBC	TSG	RPL18	GNB2L1	0.92829484	2.17E-21
GBM	Cell metabolism gene	RPL18	SNRPD2	0.875546796	1.36E-55
GBM	Epifactor	RPL18	PRMT1	0.819742897	5.28E-43
GBM	IUPHAR	RPL18	PRMT1	0.819742897	5.28E-43
HNSC	Cell metabolism gene	RPL18	SNRPD2	0.828764317	2.57E-144
KICH	Cell metabolism gene	RPL18	POLR2I	0.804471901	7.66E-22
KICH	Cell metabolism gene	RPL18	SNRPB	0.814774065	8.77E-23
KICH	Cell metabolism gene	RPL18	FAU	0.841193973	1.72E-25
KICH	Cell metabolism gene	RPL18	SNRPD2	0.919738814	6.55E-38
KICH	Epifactor	RPL18	PRMT1	0.818177266	4.16E-23
KICH	Epifactor	RPL18	RUVBL2	0.846053858	4.81E-26
KICH	IUPHAR	RPL18	PRMT1	0.818177266	4.16E-23
KICH	TF	RPL18	ZNF581	0.838088373	3.78E-25
KICH	TSG	RPL18	GADD45GIP1	0.864386766	2.59E-28
KICH	TSG	RPL18	GLTSCR2	0.866195438	1.49E-28
KIRP	Cell metabolism gene	RPL18	PGLS	0.812417178	3.43E-77
KIRP	Cell metabolism gene	RPL18	POLR2I	0.813922617	1.07E-77
KIRP	Cell metabolism gene	RPL18	SNRPD2	0.870317887	9.29E-101
KIRP	Cell metabolism gene	RPL18	FAU	0.923498276	1.28E-135
KIRP	Epifactor	RPL18	FBL	0.83944042	5.13E-87
KIRP	TF	RPL18	DRAP1	0.812262899	3.87E-77
KIRP	TF	RPL18	ZNF581	0.841376336	8.65E-88
KIRP	TSG	RPL18	GLTSCR2	0.825511953	9.70E-82
KIRP	TSG	RPL18	GADD45GIP1	0.833039984	1.57E-84
LAML	Cell metabolism gene	RPL18	FAU	0.843242371	5.72E-48
LAML	TSG	RPL18	GLTSCR2	0.819315758	3.62E-43
LGG	Epifactor	RPL18	FBL	0.879093675	4.84E-172
LGG	TF	RPL18	ZNF581	0.843746192	8.52E-145
LGG	TSG	RPL18	GLTSCR2	0.850493734	1.93E-149
LIHC	Cell metabolism gene	RPL18	PFDN5	0.810635681	6.68E-100
LIHC	Cell metabolism gene	RPL18	SNRPD2	0.824453845	3.85E-106
LIHC	Epifactor	RPL18	FBL	0.837920426	9.00E-113
LIHC	TSG	RPL18	GLTSCR2	0.814848682	9.51E-102
MESO	Cell metabolism gene	RPL18	SNRPD2	0.809254795	2.45E-21
MESO	Cell metabolism gene	RPL18	FAU	0.832636138	1.58E-23
MESO	TSG	RPL18	GLTSCR2	0.862649405	6.87E-27
PAAD	Cell metabolism gene	RPL18	FAU	0.803029775	1.51E-42
PAAD	TF	RPL18	ZNF524	0.80968071	9.31E-44
PAAD	TSG	RPL18	GLTSCR2	0.818607127	1.86E-45
PCPG	Cell metabolism gene	RPL18	PGLS	0.801981966	2.91E-43
PCPG	Cell metabolism gene	RPL18	FAU	0.812385785	3.33E-45
PCPG	Cell metabolism gene	RPL18	PFDN5	0.850568576	1.58E-53
PCPG	TF	RPL18	ZNF358	0.80566376	6.17E-44
PCPG	TF	RPL18	ZNF524	0.817433499	3.43E-46
PCPG	TSG	RPL18	GLTSCR2	0.866822484	8.24E-58
PRAD	Cell metabolism gene	RPL18	PFDN5	0.80737073	1.17E-127
PRAD	Cell metabolism gene	RPL18	NME2	0.809879626	4.71E-129
PRAD	Cell metabolism gene	RPL18	TIMM13	0.81486957	6.81E-132
PRAD	Cell metabolism gene	RPL18	MPST	0.818751389	3.66E-134
PRAD	Cell metabolism gene	RPL18	POLR2F	0.825635832	2.52E-138
PRAD	Cell metabolism gene	RPL18	PSMB7	0.830412463	2.54E-141
PRAD	Cell metabolism gene	RPL18	PGLS	0.836865459	1.60E-145
PRAD	Cell metabolism gene	RPL18	POLR2I	0.866487283	1.77E-167
PRAD	Cell metabolism gene	RPL18	SNRPD2	0.88255241	1.01E-181
PRAD	Cell metabolism gene	RPL18	FAU	0.902930993	3.97E-203
PRAD	CGC	RPL18	NACA	0.829524856	9.31E-141
PRAD	Epifactor	RPL18	RUVBL2	0.848699342	1.00E-153
PRAD	Epifactor	RPL18	FBL	0.877217582	9.02E-177
PRAD	IUPHAR	RPL18	CSNK2B	0.802162526	8.01E-125
PRAD	IUPHAR	RPL18	MPST	0.818751389	3.66E-134
PRAD	TF	RPL18	THAP3	0.800518473	6.04E-124
PRAD	TF	RPL18	ZNF581	0.806553471	3.31E-127
PRAD	TF	RPL18	NME2	0.809879626	4.71E-129
PRAD	TF	RPL18	ZNF524	0.865066091	2.62E-166
PRAD	TSG	RPL18	GADD45GIP1	0.82304761	9.72E-137
PRAD	TSG	RPL18	GLTSCR2	0.841539709	1.11E-148
PRAD	TSG	RPL18	GNB2L1	0.878833559	3.02E-178
READ	Cell metabolism gene	RPL18	SNRPD2	0.88147618	2.43E-35
SKCM	TSG	RPL18	GLTSCR2	0.844388458	5.02E-130
TGCT	Cell metabolism gene	RPL18	SNRPD2	0.803150429	1.84E-36
TGCT	Cell metabolism gene	RPL18	TBCB	0.831337138	3.98E-41
TGCT	Cell metabolism gene	RPL18	POLR2I	0.849813464	1.11E-44
TGCT	TSG	RPL18	GAS5	0.817961436	8.20E-39
TGCT	TSG	RPL18	GLTSCR2	0.818432416	6.85E-39
TGCT	TSG	RPL18	PDCD5	0.83300482	1.98E-41
THCA	Cell metabolism gene	RPL18	PFDN6	0.800585778	6.97E-129
THCA	Cell metabolism gene	RPL18	PSMB3	0.801586771	1.94E-129
THCA	Cell metabolism gene	RPL18	GFER	0.805198196	1.82E-131
THCA	Cell metabolism gene	RPL18	GPX4	0.805356643	1.48E-131
THCA	Cell metabolism gene	RPL18	EXOSC5	0.835621846	1.97E-150
THCA	Cell metabolism gene	RPL18	PGLS	0.84034044	1.01E-153
THCA	Cell metabolism gene	RPL18	DGUOK	0.841376303	1.86E-154
THCA	Cell metabolism gene	RPL18	DPM3	0.842085997	5.77E-155
THCA	Cell metabolism gene	RPL18	PFDN5	0.887708453	3.68E-194
THCA	Cell metabolism gene	RPL18	POLR2I	0.890203916	8.84E-197
THCA	Cell metabolism gene	RPL18	SNRPD2	0.910141793	2.71E-220
THCA	Cell metabolism gene	RPL18	FAU	0.928738727	8.36E-248
THCA	CGC	RPL18	HRAS	0.809947103	3.38E-134
THCA	CGC	RPL18	MAP2K2	0.843987145	2.45E-156
THCA	Epifactor	RPL18	ZNHIT1	0.801679827	1.73E-129
THCA	Epifactor	RPL18	PRPF31	0.810657842	1.30E-134
THCA	Epifactor	RPL18	RUVBL2	0.817985795	5.30E-139
THCA	Epifactor	RPL18	FBL	0.822177718	1.33E-141
THCA	Epifactor	RPL18	SIRT6	0.828895595	6.43E-146
THCA	Epifactor	RPL18	EXOSC5	0.835621846	1.97E-150
THCA	Epifactor	RPL18	TAF10	0.837017905	2.15E-151
THCA	IUPHAR	RPL18	HRAS	0.809947103	3.38E-134
THCA	IUPHAR	RPL18	SIRT6	0.828895595	6.43E-146
THCA	IUPHAR	RPL18	MAP2K2	0.843987145	2.45E-156
THCA	IUPHAR	RPL18	CSNK2B	0.859456886	3.09E-168
THCA	Kinase	RPL18	MAP2K2	0.843987145	2.45E-156
THCA	TF	RPL18	ZNF524	0.855669028	3.40E-165
THCA	TSG	RPL18	GABARAP	0.806911423	1.92E-132
THCA	TSG	RPL18	GNB2L1	0.828340612	1.49E-145
THCA	TSG	RPL18	SIRT6	0.828895595	6.43E-146
THCA	TSG	RPL18	AIP	0.857972006	4.93E-167
THCA	TSG	RPL18	GADD45GIP1	0.879966562	2.06E-186
THYM	Cell metabolism gene	RPL18	LSM4	0.803450181	8.49E-29
THYM	Cell metabolism gene	RPL18	LCMT1	0.805075532	5.44E-29
THYM	Cell metabolism gene	RPL18	DGUOK	0.807304894	2.93E-29
THYM	Cell metabolism gene	RPL18	TOMM40	0.808090414	2.35E-29
THYM	Cell metabolism gene	RPL18	PSMC5	0.808436719	2.13E-29
THYM	Cell metabolism gene	RPL18	GMPPA	0.809052318	1.79E-29
THYM	Cell metabolism gene	RPL18	MPST	0.809800984	1.45E-29
THYM	Cell metabolism gene	RPL18	WBSCR22	0.810097281	1.33E-29
THYM	Cell metabolism gene	RPL18	TIMM10	0.812332578	7.04E-30
THYM	Cell metabolism gene	RPL18	POLD2	0.812467823	6.77E-30
THYM	Cell metabolism gene	RPL18	TOMM22	0.812489948	6.73E-30
THYM	Cell metabolism gene	RPL18	PHPT1	0.820602829	6.13E-31
THYM	Cell metabolism gene	RPL18	EBP	0.822119851	3.86E-31
THYM	Cell metabolism gene	RPL18	PHKG2	0.822521897	3.42E-31
THYM	Cell metabolism gene	RPL18	PSMD13	0.822704984	3.23E-31
THYM	Cell metabolism gene	RPL18	UROD	0.822973619	2.97E-31
THYM	Cell metabolism gene	RPL18	SMPD2	0.824197516	2.04E-31
THYM	Cell metabolism gene	RPL18	MTX1	0.827755032	6.70E-32
THYM	Cell metabolism gene	RPL18	MIF	0.829258722	4.15E-32
THYM	Cell metabolism gene	RPL18	PSMB1	0.831274808	2.17E-32
THYM	Cell metabolism gene	RPL18	LSM2	0.831575819	1.97E-32
THYM	Cell metabolism gene	RPL18	GFER	0.838380769	2.05E-33
THYM	Cell metabolism gene	RPL18	MVD	0.838492315	1.98E-33
THYM	Cell metabolism gene	RPL18	ITPA	0.844170957	2.76E-34
THYM	Cell metabolism gene	RPL18	GUK1	0.84633309	1.28E-34
THYM	Cell metabolism gene	RPL18	POLR2H	0.847280336	9.07E-35
THYM	Cell metabolism gene	RPL18	PSMC3	0.847649474	7.94E-35
THYM	Cell metabolism gene	RPL18	EXOSC5	0.8483842	6.08E-35
THYM	Cell metabolism gene	RPL18	EXOSC4	0.848627716	5.56E-35
THYM	Cell metabolism gene	RPL18	IDH3G	0.854713846	5.73E-36
THYM	Cell metabolism gene	RPL18	SNRPD3	0.856500031	2.89E-36
THYM	Cell metabolism gene	RPL18	SSR2	0.86838969	2.33E-38
THYM	Cell metabolism gene	RPL18	ACOT8	0.871364455	6.48E-39
THYM	Cell metabolism gene	RPL18	PSMB3	0.872885097	3.33E-39
THYM	Cell metabolism gene	RPL18	PSMB7	0.87560196	9.89E-40
THYM	Cell metabolism gene	RPL18	DPM3	0.877475959	4.22E-40
THYM	Cell metabolism gene	RPL18	POLR2J	0.883528519	2.43E-41
THYM	Cell metabolism gene	RPL18	TIMM8B	0.885067704	1.15E-41
THYM	Cell metabolism gene	RPL18	POLR2F	0.885870609	7.72E-42
THYM	Cell metabolism gene	RPL18	APRT	0.889420795	1.29E-42
THYM	Cell metabolism gene	RPL18	SLC27A5	0.890252602	8.43E-43
THYM	Cell metabolism gene	RPL18	TIMM50	0.89566877	4.78E-44
THYM	Cell metabolism gene	RPL18	TIMM13	0.899920004	4.48E-45
THYM	Cell metabolism gene	RPL18	DPM2	0.900041239	4.18E-45
THYM	Cell metabolism gene	RPL18	POLR2I	0.905783808	1.43E-46
THYM	Cell metabolism gene	RPL18	PFDN5	0.919300843	1.99E-50
THYM	Cell metabolism gene	RPL18	PGLS	0.923781725	7.38E-52
THYM	Cell metabolism gene	RPL18	SNRPD2	0.923820676	7.17E-52
THYM	Cell metabolism gene	RPL18	FAU	0.955481756	1.86E-65
THYM	CGC	RPL18	ASPSCR1	0.810163117	1.31E-29
THYM	CGC	RPL18	SDHAF2	0.811757911	8.30E-30
THYM	CGC	RPL18	MGMT	0.837619873	2.66E-33
THYM	CGC	RPL18	MAP2K2	0.846297099	1.29E-34
THYM	CGC	RPL18	TFPT	0.865953679	6.49E-38
THYM	CGC	RPL18	RBM10	0.876051146	8.07E-40
THYM	Epifactor	RPL18	SS18L2	0.801256593	1.54E-28
THYM	Epifactor	RPL18	PELP1	0.810572398	1.17E-29
THYM	Epifactor	RPL18	PRMT1	0.813828982	4.57E-30
THYM	Epifactor	RPL18	LAS1L	0.820999221	5.44E-31
THYM	Epifactor	RPL18	PAF1	0.823239295	2.74E-31
THYM	Epifactor	RPL18	PPP4C	0.825016293	1.58E-31
THYM	Epifactor	RPL18	NOC2L	0.844526274	2.43E-34
THYM	Epifactor	RPL18	EXOSC5	0.8483842	6.08E-35
THYM	Epifactor	RPL18	EXOSC4	0.848627716	5.56E-35
THYM	Epifactor	RPL18	RUVBL2	0.852530493	1.31E-35
THYM	Epifactor	RPL18	DMAP1	0.855280396	4.62E-36
THYM	Epifactor	RPL18	C17orf49	0.858519358	1.31E-36
THYM	Epifactor	RPL18	MBD3	0.861742309	3.64E-37
THYM	Epifactor	RPL18	TFPT	0.865953679	6.49E-38
THYM	Epifactor	RPL18	INO80E	0.879345435	1.78E-40
THYM	Epifactor	RPL18	CCDC101	0.885976703	7.33E-42
THYM	Epifactor	RPL18	BRMS1	0.886149261	6.72E-42
THYM	Epifactor	RPL18	PRPF31	0.900878392	2.59E-45
THYM	Epifactor	RPL18	ZNHIT1	0.906131548	1.16E-46
THYM	Epifactor	RPL18	SIRT6	0.906702145	8.17E-47
THYM	Epifactor	RPL18	FBL	0.908892258	2.10E-47
THYM	Epifactor	RPL18	TAF10	0.909394952	1.53E-47
THYM	IUPHAR	RPL18	EGLN2	0.802087774	1.23E-28
THYM	IUPHAR	RPL18	PPIA	0.806511845	3.65E-29
THYM	IUPHAR	RPL18	MPST	0.809800984	1.45E-29
THYM	IUPHAR	RPL18	PRMT1	0.813828982	4.57E-30
THYM	IUPHAR	RPL18	PHKG2	0.822521897	3.42E-31
THYM	IUPHAR	RPL18	SMPD2	0.824197516	2.04E-31
THYM	IUPHAR	RPL18	PSMB1	0.831274808	2.17E-32
THYM	IUPHAR	RPL18	MVD	0.838492315	1.98E-33
THYM	IUPHAR	RPL18	MMP24	0.844096858	2.83E-34
THYM	IUPHAR	RPL18	MAP2K2	0.846297099	1.29E-34
THYM	IUPHAR	RPL18	SIRT3	0.849648302	3.83E-35
THYM	IUPHAR	RPL18	SLC27A5	0.890252602	8.43E-43
THYM	IUPHAR	RPL18	SIRT6	0.906702145	8.17E-47
THYM	Kinase	RPL18	PHKG2	0.822521897	3.42E-31
THYM	Kinase	RPL18	MAP2K2	0.846297099	1.29E-34
THYM	TF	RPL18	ZNF408	0.800088886	2.11E-28
THYM	TF	RPL18	ZNF444	0.805604758	4.70E-29
THYM	TF	RPL18	IRF3	0.806019389	4.19E-29
THYM	TF	RPL18	ZBTB48	0.806861909	3.31E-29
THYM	TF	RPL18	RBCK1	0.810344132	1.24E-29
THYM	TF	RPL18	THYN1	0.812101055	7.52E-30
THYM	TF	RPL18	REXO4	0.815803037	2.57E-30
THYM	TF	RPL18	GLI4	0.824494367	1.86E-31
THYM	TF	RPL18	ETV2	0.826267527	1.07E-31
THYM	TF	RPL18	DRAP1	0.828859085	4.71E-32
THYM	TF	RPL18	AKAP8L	0.83652944	3.83E-33
THYM	TF	RPL18	ZNF688	0.838989641	1.67E-33
THYM	TF	RPL18	ZNF580	0.84169427	6.57E-34
THYM	TF	RPL18	ZNF32	0.848422197	5.99E-35
THYM	TF	RPL18	ZNF581	0.856419411	2.98E-36
THYM	TF	RPL18	MBD3	0.861742309	3.64E-37
THYM	TF	RPL18	ZNF428	0.876902936	5.48E-40
THYM	TF	RPL18	THAP3	0.880539903	1.01E-40
THYM	TF	RPL18	ZNF524	0.880988017	8.20E-41
THYM	TF	RPL18	ZNF787	0.884643404	1.41E-41
THYM	TF	RPL18	THAP7	0.898006388	1.32E-44
THYM	TSG	RPL18	MAD1L1	0.805063882	5.46E-29
THYM	TSG	RPL18	IRF3	0.806019389	4.19E-29
THYM	TSG	RPL18	ZBTB48	0.806861909	3.31E-29
THYM	TSG	RPL18	GABARAP	0.837133242	3.13E-33
THYM	TSG	RPL18	SIRT3	0.849648302	3.83E-35
THYM	TSG	RPL18	PARK7	0.854239092	6.87E-36
THYM	TSG	RPL18	NPRL2	0.876647437	6.16E-40
THYM	TSG	RPL18	BRMS1	0.886149261	6.72E-42
THYM	TSG	RPL18	TSSC4	0.887888614	2.82E-42
THYM	TSG	RPL18	SIRT6	0.906702145	8.17E-47
THYM	TSG	RPL18	GLTSCR2	0.914250955	6.51E-49
THYM	TSG	RPL18	GNB2L1	0.914953051	4.06E-49
THYM	TSG	RPL18	GADD45GIP1	0.915031373	3.85E-49
UCEC	Cell metabolism gene	RPL18	FAU	0.822839876	9.83E-51
UCS	Cell metabolism gene	RPL18	LSM4	0.803450181	8.49E-29
UCS	Cell metabolism gene	RPL18	LCMT1	0.805075532	5.44E-29
UCS	Cell metabolism gene	RPL18	DGUOK	0.807304894	2.93E-29
UCS	Cell metabolism gene	RPL18	TOMM40	0.808090414	2.35E-29
UCS	Cell metabolism gene	RPL18	PSMC5	0.808436719	2.13E-29
UCS	Cell metabolism gene	RPL18	GMPPA	0.809052318	1.79E-29
UCS	Cell metabolism gene	RPL18	MPST	0.809800984	1.45E-29
UCS	Cell metabolism gene	RPL18	WBSCR22	0.810097281	1.33E-29
UCS	Cell metabolism gene	RPL18	TIMM10	0.812332578	7.04E-30
UCS	Cell metabolism gene	RPL18	POLD2	0.812467823	6.77E-30
UCS	Cell metabolism gene	RPL18	TOMM22	0.812489948	6.73E-30
UCS	Cell metabolism gene	RPL18	PHPT1	0.820602829	6.13E-31
UCS	Cell metabolism gene	RPL18	EBP	0.822119851	3.86E-31
UCS	Cell metabolism gene	RPL18	PHKG2	0.822521897	3.42E-31
UCS	Cell metabolism gene	RPL18	PSMD13	0.822704984	3.23E-31
UCS	Cell metabolism gene	RPL18	UROD	0.822973619	2.97E-31
UCS	Cell metabolism gene	RPL18	SMPD2	0.824197516	2.04E-31
UCS	Cell metabolism gene	RPL18	MTX1	0.827755032	6.70E-32
UCS	Cell metabolism gene	RPL18	MIF	0.829258722	4.15E-32
UCS	Cell metabolism gene	RPL18	PSMB1	0.831274808	2.17E-32
UCS	Cell metabolism gene	RPL18	LSM2	0.831575819	1.97E-32
UCS	Cell metabolism gene	RPL18	GFER	0.838380769	2.05E-33
UCS	Cell metabolism gene	RPL18	MVD	0.838492315	1.98E-33
UCS	Cell metabolism gene	RPL18	ITPA	0.844170957	2.76E-34
UCS	Cell metabolism gene	RPL18	GUK1	0.84633309	1.28E-34
UCS	Cell metabolism gene	RPL18	POLR2H	0.847280336	9.07E-35
UCS	Cell metabolism gene	RPL18	PSMC3	0.847649474	7.94E-35
UCS	Cell metabolism gene	RPL18	EXOSC5	0.8483842	6.08E-35
UCS	Cell metabolism gene	RPL18	EXOSC4	0.848627716	5.56E-35
UCS	Cell metabolism gene	RPL18	IDH3G	0.854713846	5.73E-36
UCS	Cell metabolism gene	RPL18	SNRPD3	0.856500031	2.89E-36
UCS	Cell metabolism gene	RPL18	SSR2	0.86838969	2.33E-38
UCS	Cell metabolism gene	RPL18	ACOT8	0.871364455	6.48E-39
UCS	Cell metabolism gene	RPL18	PSMB3	0.872885097	3.33E-39
UCS	Cell metabolism gene	RPL18	PSMB7	0.87560196	9.89E-40
UCS	Cell metabolism gene	RPL18	DPM3	0.877475959	4.22E-40
UCS	Cell metabolism gene	RPL18	POLR2J	0.883528519	2.43E-41
UCS	Cell metabolism gene	RPL18	TIMM8B	0.885067704	1.15E-41
UCS	Cell metabolism gene	RPL18	POLR2F	0.885870609	7.72E-42
UCS	Cell metabolism gene	RPL18	APRT	0.889420795	1.29E-42
UCS	Cell metabolism gene	RPL18	SLC27A5	0.890252602	8.43E-43
UCS	Cell metabolism gene	RPL18	TIMM50	0.89566877	4.78E-44
UCS	Cell metabolism gene	RPL18	TIMM13	0.899920004	4.48E-45
UCS	Cell metabolism gene	RPL18	DPM2	0.900041239	4.18E-45
UCS	Cell metabolism gene	RPL18	POLR2I	0.905783808	1.43E-46
UCS	Cell metabolism gene	RPL18	PFDN5	0.919300843	1.99E-50
UCS	Cell metabolism gene	RPL18	PGLS	0.923781725	7.38E-52
UCS	Cell metabolism gene	RPL18	SNRPD2	0.923820676	7.17E-52
UCS	Cell metabolism gene	RPL18	FAU	0.955481756	1.86E-65
UCS	CGC	RPL18	ASPSCR1	0.810163117	1.31E-29
UCS	CGC	RPL18	SDHAF2	0.811757911	8.30E-30
UCS	CGC	RPL18	MGMT	0.837619873	2.66E-33
UCS	CGC	RPL18	MAP2K2	0.846297099	1.29E-34
UCS	CGC	RPL18	TFPT	0.865953679	6.49E-38
UCS	CGC	RPL18	RBM10	0.876051146	8.07E-40
UCS	Epifactor	RPL18	SS18L2	0.801256593	1.54E-28
UCS	Epifactor	RPL18	PELP1	0.810572398	1.17E-29
UCS	Epifactor	RPL18	PRMT1	0.813828982	4.57E-30
UCS	Epifactor	RPL18	LAS1L	0.820999221	5.44E-31
UCS	Epifactor	RPL18	PAF1	0.823239295	2.74E-31
UCS	Epifactor	RPL18	PPP4C	0.825016293	1.58E-31
UCS	Epifactor	RPL18	NOC2L	0.844526274	2.43E-34
UCS	Epifactor	RPL18	EXOSC5	0.8483842	6.08E-35
UCS	Epifactor	RPL18	EXOSC4	0.848627716	5.56E-35
UCS	Epifactor	RPL18	RUVBL2	0.852530493	1.31E-35
UCS	Epifactor	RPL18	DMAP1	0.855280396	4.62E-36
UCS	Epifactor	RPL18	C17orf49	0.858519358	1.31E-36
UCS	Epifactor	RPL18	MBD3	0.861742309	3.64E-37
UCS	Epifactor	RPL18	TFPT	0.865953679	6.49E-38
UCS	Epifactor	RPL18	INO80E	0.879345435	1.78E-40
UCS	Epifactor	RPL18	CCDC101	0.885976703	7.33E-42
UCS	Epifactor	RPL18	BRMS1	0.886149261	6.72E-42
UCS	Epifactor	RPL18	PRPF31	0.900878392	2.59E-45
UCS	Epifactor	RPL18	ZNHIT1	0.906131548	1.16E-46
UCS	Epifactor	RPL18	SIRT6	0.906702145	8.17E-47
UCS	Epifactor	RPL18	FBL	0.908892258	2.10E-47
UCS	Epifactor	RPL18	TAF10	0.909394952	1.53E-47
UCS	IUPHAR	RPL18	EGLN2	0.802087774	1.23E-28
UCS	IUPHAR	RPL18	PPIA	0.806511845	3.65E-29
UCS	IUPHAR	RPL18	MPST	0.809800984	1.45E-29
UCS	IUPHAR	RPL18	PRMT1	0.813828982	4.57E-30
UCS	IUPHAR	RPL18	PHKG2	0.822521897	3.42E-31
UCS	IUPHAR	RPL18	SMPD2	0.824197516	2.04E-31
UCS	IUPHAR	RPL18	PSMB1	0.831274808	2.17E-32
UCS	IUPHAR	RPL18	MVD	0.838492315	1.98E-33
UCS	IUPHAR	RPL18	MMP24	0.844096858	2.83E-34
UCS	IUPHAR	RPL18	MAP2K2	0.846297099	1.29E-34
UCS	IUPHAR	RPL18	SIRT3	0.849648302	3.83E-35
UCS	IUPHAR	RPL18	SLC27A5	0.890252602	8.43E-43
UCS	IUPHAR	RPL18	SIRT6	0.906702145	8.17E-47
UCS	Kinase	RPL18	PHKG2	0.822521897	3.42E-31
UCS	Kinase	RPL18	MAP2K2	0.846297099	1.29E-34
UCS	TF	RPL18	ZNF408	0.800088886	2.11E-28
UCS	TF	RPL18	ZNF444	0.805604758	4.70E-29
UCS	TF	RPL18	IRF3	0.806019389	4.19E-29
UCS	TF	RPL18	ZBTB48	0.806861909	3.31E-29
UCS	TF	RPL18	RBCK1	0.810344132	1.24E-29
UCS	TF	RPL18	THYN1	0.812101055	7.52E-30
UCS	TF	RPL18	REXO4	0.815803037	2.57E-30
UCS	TF	RPL18	GLI4	0.824494367	1.86E-31
UCS	TF	RPL18	ETV2	0.826267527	1.07E-31
UCS	TF	RPL18	DRAP1	0.828859085	4.71E-32
UCS	TF	RPL18	AKAP8L	0.83652944	3.83E-33
UCS	TF	RPL18	ZNF688	0.838989641	1.67E-33
UCS	TF	RPL18	ZNF580	0.84169427	6.57E-34
UCS	TF	RPL18	ZNF32	0.848422197	5.99E-35
UCS	TF	RPL18	ZNF581	0.856419411	2.98E-36
UCS	TF	RPL18	MBD3	0.861742309	3.64E-37
UCS	TF	RPL18	ZNF428	0.876902936	5.48E-40
UCS	TF	RPL18	THAP3	0.880539903	1.01E-40
UCS	TF	RPL18	ZNF524	0.880988017	8.20E-41
UCS	TF	RPL18	ZNF787	0.884643404	1.41E-41
UCS	TF	RPL18	THAP7	0.898006388	1.32E-44
UCS	TSG	RPL18	MAD1L1	0.805063882	5.46E-29
UCS	TSG	RPL18	IRF3	0.806019389	4.19E-29
UCS	TSG	RPL18	ZBTB48	0.806861909	3.31E-29
UCS	TSG	RPL18	GABARAP	0.837133242	3.13E-33
UCS	TSG	RPL18	SIRT3	0.849648302	3.83E-35
UCS	TSG	RPL18	PARK7	0.854239092	6.87E-36
UCS	TSG	RPL18	NPRL2	0.876647437	6.16E-40
UCS	TSG	RPL18	BRMS1	0.886149261	6.72E-42
UCS	TSG	RPL18	TSSC4	0.887888614	2.82E-42
UCS	TSG	RPL18	SIRT6	0.906702145	8.17E-47
UCS	TSG	RPL18	GLTSCR2	0.914250955	6.51E-49
UCS	TSG	RPL18	GNB2L1	0.914953051	4.06E-49
UCS	TSG	RPL18	GADD45GIP1	0.915031373	3.85E-49
UVM	Cell metabolism gene	RPL18	SAT2	0.803966738	2.75E-19
UVM	Cell metabolism gene	RPL18	SLC27A5	0.812254451	6.05E-20
UVM	Cell metabolism gene	RPL18	SLC25A6	0.828379185	2.53E-21
UVM	Cell metabolism gene	RPL18	MPST	0.845259402	6.25E-23
UVM	Cell metabolism gene	RPL18	SSR2	0.877950579	1.14E-26
UVM	Cell metabolism gene	RPL18	FAU	0.928137787	3.24E-35
UVM	CGC	RPL18	TRAF7	0.818662193	1.78E-20
UVM	Epifactor	RPL18	TRIM28	0.846639421	4.53E-23
UVM	Epifactor	RPL18	FBL	0.953220071	2.80E-42
UVM	IUPHAR	RPL18	SLC27A5	0.812254451	6.05E-20
UVM	IUPHAR	RPL18	SLC25A6	0.828379185	2.53E-21
UVM	IUPHAR	RPL18	MPST	0.845259402	6.25E-23
UVM	IUPHAR	RPL18	TRIM28	0.846639421	4.53E-23
UVM	Kinase	RPL18	TRIM28	0.846639421	4.53E-23
UVM	TF	RPL18	REXO4	0.804371287	2.56E-19
UVM	TF	RPL18	ZNF581	0.870809069	9.12E-26
UVM	TSG	RPL18	GNB2L1	0.902742237	2.65E-30
UVM	TSG	RPL18	GLTSCR2	0.926762257	6.60E-35

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL18	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL18	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL18	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL18	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL18	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL18	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL18	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL18	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL18	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL18	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL18	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL18	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL18	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL18	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL18	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL18	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL18	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL18	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL18	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL18	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL18	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL18	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL18	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL18	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL18	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL18	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL18	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL18	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL18

FANCA, FANCC, ESR1, CD4, NOP56, DYRK2, EBNA-LP, ARRB2, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, RPL10A, RPL11, RPL12, RPL13, RPL15, RPL18A, RPL19, RPL21, RPL22, RPL23, RPL24, RPL27A, RPL31, RPL37A, RPL3, RPL4, RPL5, RPL6, RPL7A, RPL7, RPL8, RPL9, RPS13, RPS14, RPS15A, RPS16, RPS19, RPS23, RPS25, RPS26, RPS28, RPS2, RPS3A, RPS3, RPS4X, RPS5, RPS6, RPS7, RPS8, RPSA, RPL23A, RPL14, RPL30, RPS24, RPS12, RPS20, RPS11, RPLP0, RPL36, RPL27, RPS9, RPL10, RPL35, RPS17, RPL38, RPL17, RPL32, RPS21, RPS27A, EEF2, EEF1A1, FBL, ILF3, HNRNPU, NCL, SLC25A5, ILF2, MYBBP1A, EEF1D, NHP2L1, ACTA2, HNRNPM, U2AF2, RPS27L, ATP5A1, MYL12A, RPL10L, RPLP0P6, NOP2, PTGES3, RPS10P5, ATP5B, HIST1H2AD, NIFK, HSP90AA5P, RHOA, TUBA1B, MRPL12, MAGOH, EIF4A3, PA2G4, FN1, VCAM1, IL7R, UBL4A, ITGA4, PAN2, IGSF8, ICAM1, CDKN1A, FBXO6, EEF1E1, FAU, IARS, NUDT21, RPA3, RPA2, RPA1, ZBTB1, STAU1, CEP250, TP53, HUWE1, FUS, CUL7, OBSL1, CCDC8, EED, RBM4B, NTRK1, HNRNPUL2, PABPC1, PABPC4, RPL13A, RPL26L1, RPL3L, RPLP1, RPS27, RPL26, RPL34, RPL35A, RPLP2, RPS10, RPS15, RPS18, LOC101929876, SFN, XPO1, NPM1, CENPQ, Srp72, Rrbp1, Brwd3, SKI, MCM2, NF2, RC3H1, ZNF746, CEBPZ, PDCD11, FNTB, VPRBP, UBE2O, NOC2L, RRP8, CNBP, NLE1, NSUN4, KIAA0020, MINA, GNL2, RRS1, EBNA1BP2, CENPC, REXO4, TTC19, RBM34, NOL8, NAP1L1, GTPBP4, RBM28, ZC3H10, SPTY2D1, DKC1, DDX10, C1QBP, FTSJ3, MRPL48, DDX27, FNTA, MECP2, BRIX1, NAP1L4, ZNF512, MRPS31, DDX51, ZNF22, ZC3HAV1, DDX24, DDX52, MRPL16, RRP7A, MRPS33, MRPL28, ZNF644, HERC5, MRPS9, FCF1, MRPL13, MRPS18C, MRPL32, MRPS35, RBM19, DDX54, NOC3L, RPL28, MRPL47, URB1, DDX56, DHX30, RRP1, ZNF771, BUD13, RPF2, PAK1IP1, MRPL27, MRPL24, NSA2, DDX18, C3orf17, MRPL20, PPAN-P2RY11, MRPL17, MRPS5, MRPL3, UTP3, GNL3, MRPS10, MRPL51, CYLD, INO80B, TRIM25, BRCA1, YAP1, DDX39B, IQGAP1, HBP1, BMP4, CTNNB1, KRAS, TRIP4, API5, ARNT, GSK3A, HNF1B, PCBP1, PPIE, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, RNF4, CHD4, RIOK1, FGF11, MEPCE, LARP7, SNAI1, AGR2, RECQL4, REST, MYC, CDK9, RPS6KB2, C1orf106, GRWD1, METTL14, EIF4B, RC3H2, PHB, RBX1, KIN, USP14, NR2C2, UBQLN2, PPP1CC, HDAC2, VRK1, HIST1H4A, SNRNP70, Dppa3, ITFG1, HMGB1, BIRC3, NFX1, WWP2, MATR3, Dnajc17, SOX2, ARIH2, PLEKHA4, PINK1, TFCP2, FANCD2, HCVgp1, ZC3H18, GRB7, MAP3K14, PRKD1, PTPN6, RAB5A, STRN4, TJP2, AUTS2, SNIP1, M, nsp13, nsp4, nsp5, nsp6, ORF3a, ORF7a, MAP1LC3B, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, GRSF1, MKI67, ACACA, LRRC59, NDN, MAFB, BRD4, NINL, Apc2, RBM39, LGALS9, RIN3, DNAJB7, DNAJC15, DNAJC16, DNAJC19, DNAJC1, DNAJC21, DNAJC25, DNAJC28, DNAJC2, DRG1, SEC63, KDF1, DDX58, TRIM37, PARK2, UFL1, DDRGK1, ATG7, USP15, FZR1, WDR5, NUDCD2, NAA40, ADARB1, UTP23, LYAR, SURF6, NPM3, DDX21, MRPS24, PRKRA, H2AFB2, MRPL9, SPPL3, FGF13, HIST1H1B, H2AFB3, PATZ1, PURG, NVL, SRSF6, SRSF5, ZBTB47, HP1BP3, RSL1D1, CCDC140, ZNF48, ABT1, RRP9, RPF1, ZNF668, SART3, ZNF770, IPO7, MDM2, MAGEB2, ZNF346, HIST1H1E, DDA1, LIN28A, IL17B, SPRTN, BTF3, FBXW7, Cstf2t, NLRP7, RCHY1, CCNF, N, SIRT6, EIF2AK2,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPL18	chr19	49119208	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL18	chr19	49119445	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
RPL18	chr19	49119900	C	CCAGCA	Microsatellite	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL18	chr19	49119900	C	CCAGCACAGCA	Microsatellite	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL18	chr19	49119900	C	CCAGCACAGCACAGCA	Microsatellite	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL18	chr19	49119900	C	CCAGCACAGCACAGCACAGCA	Microsatellite	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL18	chr19	49120040	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
RPL18	chr19	49120087	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL18	chr19	49120252	T	TA	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL18	chr19	49120434	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL18	chr19	49120619	A	G	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_18	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
RPL18	chr19	49120629	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
RPL18	chr19	49120684	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL18	chr19	49120774	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL18	chr19	49121096	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL18	chr19	49121132	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL18	chr19	49121307	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL18	chr19	49122248	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL18	UCEC	chr19	49119901	49119905	CAGCA	-	Frame_Shift_Del	p.V125fs	6
RPL18	BRCA	chr19	49119404	49119404	C	A	Missense_Mutation	p.G118V	3
RPL18	SKCM	chr19	49119388	49119388	G	A	Silent	p.F123F	3
RPL18	SKCM	chr19	49120585	49120585	G	A	Silent	p.S62S	3
RPL18	THCA	chr19	49119429	49119429	G	T	Missense_Mutation		2
RPL18	SKCM	chr19	49120620	49120620	A	G	Silent	p.L51L	2
RPL18	THYM	chr19	49120073	49120073	C	T	Silent		2
RPL18	THYM	chr19	49120073	49120073	C	T	Silent	p.K69K	2
RPL18	LIHC	chr19	49121059	49121059	G	T	Missense_Mutation	p.L27M	2
RPL18	LIHC	chr19	49119365	49119365	G	-	Frame_Shift_Del	p.P131fs	2
RPL18	BLCA	chr19	49119427	49119427	G	A	Silent	p.R110R	2
RPL18	CESC	chr19	49119188	49119188	C	T	Missense_Mutation	p.R146Q	2
RPL18	LIHC	chr19	49118633	49118633	T	-	Frame_Shift_Del	p.N188fs	2
RPL18	UCEC	chr19	49120016	49120016	A	T	Missense_Mutation	p.D88E	2
RPL18	STAD	chr19	49120043	49120043	C	T	Silent		2
RPL18	BRCA	chr19	49119337	49119337	G	A	Silent	p.S140	2
RPL18	STAD	chr19	49120017	49120017	T	C	Missense_Mutation	p.D88G	2
RPL18	KIRC	chr19	49119434	49119434	C	T	Missense_Mutation	p.R108Q	2
RPL18	PAAD	chr19	49119337	49119337	G	A	Silent	p.S140S	2
RPL18	BRCA	chr19	49119900	49119901	-	CAGCACAGCA	Frame_Shift_Ins	p.V126fs	2
RPL18	STAD	chr19	49118647	49118647	G	A	Silent	p.S183S	2
RPL18	BRCA	chr19	49119900	49119901	-	CAGCACAGCACAGCA	In_Frame_Ins	p.126in_frame_insCCAVL	2
RPL18	STAD	chr19	49119424	49119424	G	A	Silent	p.S111S	2
RPL18	SKCM	chr19	49120029	49120029	C	T	Missense_Mutation	p.G84E	2
RPL18	BRCA	chr19	49119901	49119910	CAGCACAGCA	-	Frame_Shift_Del	p.C123fs	2
RPL18	SKCM	chr19	49119171	49119171	A	T	Missense_Mutation	p.F152I	2
RPL18	LIHC	chr19	49119341	49119341	A	G	Missense_Mutation		1
RPL18	BLCA	chr19	49120576	49120576	C	T	Silent		1
RPL18	CESC	chr19	49119188	49119188	C	T	Missense_Mutation		1
RPL18	LIHC	chr19	49121059	49121059	G	T	Missense_Mutation		1
RPL18	BLCA	chr19	49118689	49118689	G	C	Silent		1
RPL18	CESC	chr19	49119415	49119415	G	A	Silent		1
RPL18	BLCA	chr19	49119376	49119376	G	A	Silent		1
RPL18	CESC	chr19	49118632	49118632	G	T	Missense_Mutation		1
RPL18	THYM	chr19	49120073	49120073	C	T	Missense_Mutation	p.D67N	1
RPL18	SKCM	chr19	49119189	49119189	G	A	Nonsense_Mutation	p.R146*	1
RPL18	BLCA	chr19	49120576	49120576	C	T	Silent	p.R65R	1
RPL18	SKCM	chr19	49120079	49120079	G	A	Silent	p.I67I	1
RPL18	ESCA	chr19	49119166	49119166	G	T	Silent	p.G153G	1
RPL18	PAAD	chr19	49119337	49119337	G	A	Silent		1
RPL18	BLCA	chr19	49118689	49118689	G	C	Silent	p.S169S	1
RPL18	KIRC	chr19	49121088	49121088	T	G	Missense_Mutation	p.E17A	1
RPL18	PAAD	chr19	49120059	49120059	C	T	Missense_Mutation		1
RPL18	KIRP	chr19	49118705	49118705	C	T	Splice_Site		1
RPL18	PAAD	chr19	49120059	49120059	C	T	Missense_Mutation	p.G74D	1
RPL18	KIRP	chr19	49119186	49119186	C	A	Missense_Mutation		1
RPL18	BLCA	chr19	49119427	49119427	G	A	Silent		1
RPL18	STAD	chr19	49120043	49120043	C	T	Silent	p.T79T	1
RPL18	LIHC	chr19	49119357	49119357	A	G	Missense_Mutation		1
RPL18	BLCA	chr19	49120638	49120638	G	T	Missense_Mutation		1

Copy number variation (CNV) of RPL18
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL18
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
88134	N/A	AA554527	ARL15	chr5	53482722	+	RPL18	chr19	49118588	+
88134	N/A	EC499035	C16orf90	chr16	3546322	-	RPL18	chr19	49120573	+
88134	N/A	AA532484	CXADR	chr21	18948405	-	RPL18	chr19	49118588	+
88134	N/A	AX193381	DACT3	chr19	47157734	-	RPL18	chr19	49118588	+
88134	COAD	TCGA-AA-3552-01A	GUCA2A	chr1	42630362	-	RPL18	chr19	49119203	-
88134	GBM	TCGA-27-1830-01A	MVB12B	chr9	129268028	+	RPL18	chr19	49119461	-
88134	N/A	AX381155	NAT8L	chr4	2061539	+	RPL18	chr19	49122421	-
88134	N/A	BE881549	PDIA4	chr7	148709083	-	RPL18	chr19	49120010	-
86917	HNSC	TCGA-CV-7253-01A	RPL18	chr19	49118590	-	ABCF1	chr6	30545853	+
76077	N/A	BI861723	RPL18	chr19	49118588	-	ANKRD20A5P	chr18	14202267	+
94274	PRAD	TCGA-XQ-A8TA-01A	RPL18	chr19	49118588	-	AR	chrX	66914515	+
76077	N/A	CA309686	RPL18	chr19	49119421	+	C15orf57	chr15	40845397	+
102358	N/A	BF344300	RPL18	chr19	49118585	-	CERS4	chr19	8295085	-
94750	HNSC	TCGA-CR-7376-01A	RPL18	chr19	49118585	-	CFB	chr6	31913427	+
102173	HNSC	TCGA-D6-A6EP-01A	RPL18	chr19	49118650	-	COL1A1	chr17	48278993	-
102756	UCS	TCGA-NA-A4QX-01A	RPL18	chr19	49118590	-	DDX27	chr20	47849303	+
103262	LUSC	TCGA-18-3412	RPL18	chr19	49119432	-	EEF1A1	chr6	74227934	-
100195	N/A	BG574621	RPL18	chr19	49118588	-	EFCAB6	chr22	43944419	+
76077	N/A	D57272	RPL18	chr19	49118665	+	EGR3	chr8	22545541	-
80170	N/A	BI859902	RPL18	chr19	49118588	-	ELMOD1	chr11	107528991	-
99835	COAD	TCGA-CM-4746-01A	RPL18	chr19	49120009	-	ETV5	chr3	185826703	-
87241	N/A	AI699466	RPL18	chr19	49118691	+	FAM134C	chr17	40734722	+
96636	SKCM	TCGA-EE-A2MG-06A	RPL18	chr19	49118590	-	FAR1	chr11	13744912	+
76077	N/A	BI857043	RPL18	chr19	49118589	-	FILIP1L	chr3	99623466	-
93687	N/A	DW439793	RPL18	chr19	49119986	-	GANAB	chr11	62392381	-
96843	UCEC	TCGA-AP-A05H-01A	RPL18	chr19	49119137	-	IGF2	chr11	2152923	-
98452	N/A	CN269392	RPL18	chr19	49119141	-	LGMN	chr14	93170270	-
96683	N/A	BG575251	RPL18	chr19	49118588	-	MEIS2	chr15	37198825	+
84030	N/A	BQ776047	RPL18	chr19	49118684	+	NDC80	chr18	2606477	-
100884	N/A	AA516125	RPL18	chr19	49118641	+	NFE2L2	chr2	178095254	+
78664	N/A	BF526287	RPL18	chr19	49118588	-	NLGN4Y	chrY	16692070	+
93513	BLCA	TCGA-GV-A3JV-01A	RPL18	chr19	49118588	-	PLEKHB2	chr2	131876464	+
76077	N/A	BG911000	RPL18	chr19	49118588	-	PTCHD1	chrX	23356032	+
101666	LUSC	TCGA-90-A4ED-01A	RPL18	chr19	49118590	-	RABEP1	chr17	5283828	+
76077	N/A	BM015027	RPL18	chr19	49118588	-	RBP5	chr12	7278667	+
76077	N/A	BF339667	RPL18	chr19	49118588	-	RGS13	chr1	192625502	-
95664	COAD	TCGA-DM-A1D8	RPL18	chr19	49122397	-	RPS2	chr16	2013257	-
86943	N/A	EC561277	RPL18	chr19	49118621	+	SETD7	chr4	140427313	-
76077	SKCM	TCGA-D9-A4Z6-01A	RPL18	chr19	49118590	-	SLC38A5	chrX	48327824	-
76077	N/A	BM014158	RPL18	chr19	49118588	-	SMIM2-AS1	chr13	44740697	-
97721	PRAD	TCGA-J9-A8CN-01A	RPL18	chr19	49118588	-	SQSTM1	chr5	179250858	+
99445	N/A	CA489424	RPL18	chr19	49118588	-	SYNGR1	chr22	39757382	-
88863	PRAD	TCGA-VN-A88I-01A	RPL18	chr19	49118650	-	TAGLN	chr11	117070098	+
76077	N/A	BG575017	RPL18	chr19	49118588	-	TEN1-CDK3	chr17	73981925	-
87356	N/A	BG031551	RPL18	chr19	49118588	-	TENM3	chr4	182915891	-
76077	N/A	AW276460	RPL18	chr19	49119404	+	TMED1	chr19	10943795	+
98527	SKCM	TCGA-D9-A4Z3-01A	RPL18	chr19	49118590	-	ZNF827	chr4	146859787	-
88134	LIHC	TCGA-CC-A5UE-01A	SUPT20H	chr13	37633722	-	RPL18	chr19	49121132	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
ACC	RPL18	2.12224498040134	0.752474481408188	0.00225264928614051	0.00353293411358054	0.00263127790797774	79
LGG	RPL18	0.757130732352805	-0.278219342499114	0.0404384622970421	0.0383170717060842	0.0411005296676949	525
BRCA	RPL18	0.834706695920855	-0.180674878208592	0.0455108985686821	0.0439635489621747	0.0457035203241265	1200
UVM	RPL18	0.641945039387915	-0.443252587386826	0.0496644946812498	0.0496021721841614	0.0467775047803964	80

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPL18	0.0139692922608322	0.39

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL18	0.015627726932881	0.5
PAAD	RPL18	0.00793410760500117	0.26

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0024623	Malignant neoplasm of stomach	1	CTD_human
C1260899	Anemia, Diamond-Blackfan	1	GENOMICS_ENGLAND;ORPHANET
C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
C2931850	Aase Smith syndrome 2	1	ORPHANET