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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL18A (NCBI Gene ID:6142)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL18A
	Gene ID: 6142
	Gene Symbol	RPL18A
	Gene ID	6142
	Gene Name	ribosomal protein L18a
	Synonyms	L18A
	Cytomap	19p13.11
	Type of Gene	protein-coding
	Description	60S ribosomal protein L18alarge ribosomal subunit protein eL20ribosomal protein L18a-like protein
	Modification date	20200313
	UniProtAcc	Q02543

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPL18A	GO:0002181	cytoplasmic translation	25957688

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL18A	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL18A[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL18A	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000222247	17972902	17973032	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRP	RPL18A	-1.51651392808885	0.00016188295558095
PRAD	RPL18A	1.40600175748499	0.00205137828390396
KIRC	RPL18A	-4.43079304960843	9.2516163152192e-11

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
ESCA	RPL18A	0.021623188	0.013088464

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL18A (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	TF	RPL18A	ZNF581	0.803050333	5.48E-19
CHOL	Cell metabolism gene	RPL18A	PFDN5	0.842859493	3.81E-13
CHOL	Cell metabolism gene	RPL18A	SNRPD2	0.869745748	8.95E-15
CHOL	CGC	RPL18A	NACA	0.836976965	7.90E-13
CHOL	Epifactor	RPL18A	FBL	0.895966101	9.35E-17
CHOL	TSG	RPL18A	GNB2L1	0.827773342	2.33E-12
DLBC	Cell metabolism gene	RPL18A	POLR2L	0.807488288	4.09E-12
DLBC	Cell metabolism gene	RPL18A	POLR2I	0.813295095	2.16E-12
DLBC	Cell metabolism gene	RPL18A	POLR2J	0.820324562	9.70E-13
DLBC	Cell metabolism gene	RPL18A	PSMB3	0.82236884	7.63E-13
DLBC	Cell metabolism gene	RPL18A	LSM2	0.831733755	2.44E-13
DLBC	Cell metabolism gene	RPL18A	PTDSS2	0.835821404	1.45E-13
DLBC	Cell metabolism gene	RPL18A	POLR2F	0.837860705	1.12E-13
DLBC	Cell metabolism gene	RPL18A	GFER	0.851893805	1.63E-14
DLBC	Cell metabolism gene	RPL18A	PFDN5	0.861467437	3.91E-15
DLBC	Cell metabolism gene	RPL18A	TIMM13	0.865582251	2.05E-15
DLBC	Cell metabolism gene	RPL18A	GEMIN7	0.866103912	1.88E-15
DLBC	Cell metabolism gene	RPL18A	TOMM22	0.873101665	5.93E-16
DLBC	Cell metabolism gene	RPL18A	TIMM9	0.873844811	5.22E-16
DLBC	Cell metabolism gene	RPL18A	NME2	0.892950889	1.48E-17
DLBC	Cell metabolism gene	RPL18A	FAU	0.894403729	1.10E-17
DLBC	Cell metabolism gene	RPL18A	SNRPD2	0.898625248	4.50E-18
DLBC	CGC	RPL18A	NACA	0.823950144	6.32E-13
DLBC	Epifactor	RPL18A	ZNHIT1	0.804514355	5.62E-12
DLBC	Epifactor	RPL18A	FBL	0.889543657	2.93E-17
DLBC	IUPHAR	RPL18A	MFSD2B	0.800847687	8.26E-12
DLBC	IUPHAR	RPL18A	SLC25A26	0.804140542	5.85E-12
DLBC	TF	RPL18A	ZNF444	0.807689504	4.00E-12
DLBC	TF	RPL18A	THAP7	0.821437475	8.51E-13
DLBC	TF	RPL18A	THAP4	0.821908925	8.05E-13
DLBC	TF	RPL18A	ZNF581	0.827517201	4.11E-13
DLBC	TF	RPL18A	NME2	0.892950889	1.48E-17
DLBC	TSG	RPL18A	GLTSCR2	0.85036348	2.03E-14
DLBC	TSG	RPL18A	GADD45GIP1	0.85985309	5.01E-15
DLBC	TSG	RPL18A	GNB2L1	0.902091887	2.10E-18
KIRP	Cell metabolism gene	RPL18A	FAU	0.805339135	7.06E-75
KIRP	Cell metabolism gene	RPL18A	SNRPD2	0.806693588	2.59E-75
KIRP	Epifactor	RPL18A	FBL	0.804496056	1.31E-74
LAML	Cell metabolism gene	RPL18A	FAU	0.816351796	1.27E-42
LGG	Cell metabolism gene	RPL18A	FAU	0.863718342	2.99E-159
LGG	TSG	RPL18A	GLTSCR2	0.806869345	8.44E-123
LGG	TSG	RPL18A	GNB2L1	0.849580576	8.44E-149
MESO	Cell metabolism gene	RPL18A	FAU	0.819277999	3.08E-22
PCPG	TSG	RPL18A	GNB2L1	0.802119496	2.75E-43
PCPG	TSG	RPL18A	GLTSCR2	0.818649839	1.96E-46
PRAD	Cell metabolism gene	RPL18A	FAU	0.806014853	6.54E-127
PRAD	Cell metabolism gene	RPL18A	TIMM9	0.809596274	6.79E-129
PRAD	Cell metabolism gene	RPL18A	TIMM13	0.809654328	6.30E-129
PRAD	Cell metabolism gene	RPL18A	SNRPD2	0.821921189	4.68E-136
PRAD	Cell metabolism gene	RPL18A	NME2	0.829788857	6.33E-141
PRAD	CGC	RPL18A	NACA	0.804192487	6.45E-126
PRAD	Epifactor	RPL18A	FBL	0.865831312	6.17E-167
PRAD	TF	RPL18A	ZNF524	0.808672275	2.23E-128
PRAD	TF	RPL18A	NME2	0.829788857	6.33E-141
PRAD	TF	RPL18A	ZNF581	0.84078741	3.63E-148
PRAD	TSG	RPL18A	GNB2L1	0.864327677	1.05E-165
SKCM	TSG	RPL18A	GLTSCR2	0.803282317	2.74E-108
THYM	Cell metabolism gene	RPL18A	PSMB6	0.800395686	1.94E-28
THYM	Cell metabolism gene	RPL18A	UROD	0.801215094	1.56E-28
THYM	Cell metabolism gene	RPL18A	MTMR14	0.802765941	1.02E-28
THYM	Cell metabolism gene	RPL18A	MTX1	0.803118755	9.30E-29
THYM	Cell metabolism gene	RPL18A	PSMB10	0.803119771	9.30E-29
THYM	Cell metabolism gene	RPL18A	DGUOK	0.803487675	8.41E-29
THYM	Cell metabolism gene	RPL18A	DPM3	0.803713853	7.90E-29
THYM	Cell metabolism gene	RPL18A	WBSCR22	0.806764502	3.40E-29
THYM	Cell metabolism gene	RPL18A	SNRPD1	0.817454246	1.58E-30
THYM	Cell metabolism gene	RPL18A	POLR2J	0.817659242	1.48E-30
THYM	Cell metabolism gene	RPL18A	PHKG2	0.818061154	1.32E-30
THYM	Cell metabolism gene	RPL18A	PGP	0.818288316	1.23E-30
THYM	Cell metabolism gene	RPL18A	PSMD4	0.818572003	1.13E-30
THYM	Cell metabolism gene	RPL18A	IDH3G	0.818905932	1.02E-30
THYM	Cell metabolism gene	RPL18A	IMPDH2	0.819360102	8.92E-31
THYM	Cell metabolism gene	RPL18A	TIMM17B	0.819935069	7.50E-31
THYM	Cell metabolism gene	RPL18A	DGKZ	0.820420436	6.48E-31
THYM	Cell metabolism gene	RPL18A	GALK1	0.821628466	4.49E-31
THYM	Cell metabolism gene	RPL18A	POLR3K	0.822478917	3.46E-31
THYM	Cell metabolism gene	RPL18A	POLD4	0.822534125	3.40E-31
THYM	Cell metabolism gene	RPL18A	PSMB1	0.822679791	3.26E-31
THYM	Cell metabolism gene	RPL18A	POLA2	0.822804841	3.13E-31
THYM	Cell metabolism gene	RPL18A	SEC61G	0.823194932	2.78E-31
THYM	Cell metabolism gene	RPL18A	TOMM40	0.823395832	2.61E-31
THYM	Cell metabolism gene	RPL18A	GCDH	0.825326377	1.44E-31
THYM	Cell metabolism gene	RPL18A	TIMM10	0.826807282	9.03E-32
THYM	Cell metabolism gene	RPL18A	LSM3	0.827039786	8.39E-32
THYM	Cell metabolism gene	RPL18A	TBCB	0.827045567	8.38E-32
THYM	Cell metabolism gene	RPL18A	PAFAH1B3	0.829357366	4.02E-32
THYM	Cell metabolism gene	RPL18A	OAZ1	0.829664154	3.64E-32
THYM	Cell metabolism gene	RPL18A	SNRPD3	0.833549914	1.03E-32
THYM	Cell metabolism gene	RPL18A	GMPPA	0.834888646	6.63E-33
THYM	Cell metabolism gene	RPL18A	NOP56	0.836006204	4.57E-33
THYM	Cell metabolism gene	RPL18A	SNRPE	0.836100503	4.43E-33
THYM	Cell metabolism gene	RPL18A	GEMIN7	0.839620198	1.34E-33
THYM	Cell metabolism gene	RPL18A	SNRPB	0.8406941	9.29E-34
THYM	Cell metabolism gene	RPL18A	NANS	0.840808465	8.93E-34
THYM	Cell metabolism gene	RPL18A	DPM2	0.841029503	8.28E-34
THYM	Cell metabolism gene	RPL18A	LSM4	0.845775019	1.56E-34
THYM	Cell metabolism gene	RPL18A	POLR2I	0.847404155	8.67E-35
THYM	Cell metabolism gene	RPL18A	SMPD2	0.847936379	7.15E-35
THYM	Cell metabolism gene	RPL18A	EBP	0.849877208	3.52E-35
THYM	Cell metabolism gene	RPL18A	MVD	0.851363292	2.03E-35
THYM	Cell metabolism gene	RPL18A	PMPCA	0.853078783	1.07E-35
THYM	Cell metabolism gene	RPL18A	TALDO1	0.853670336	8.53E-36
THYM	Cell metabolism gene	RPL18A	PFDN5	0.854091595	7.27E-36
THYM	Cell metabolism gene	RPL18A	HMBS	0.857002076	2.38E-36
THYM	Cell metabolism gene	RPL18A	POLR2H	0.859639883	8.44E-37
THYM	Cell metabolism gene	RPL18A	PSME1	0.861191573	4.54E-37
THYM	Cell metabolism gene	RPL18A	DTYMK	0.861393973	4.19E-37
THYM	Cell metabolism gene	RPL18A	APRT	0.86299963	2.19E-37
THYM	Cell metabolism gene	RPL18A	POLR2F	0.863833906	1.56E-37
THYM	Cell metabolism gene	RPL18A	SRM	0.868900335	1.87E-38
THYM	Cell metabolism gene	RPL18A	ITPA	0.868949799	1.83E-38
THYM	Cell metabolism gene	RPL18A	TIMM50	0.869985727	1.18E-38
THYM	Cell metabolism gene	RPL18A	GUK1	0.870892958	7.95E-39
THYM	Cell metabolism gene	RPL18A	PSMD13	0.87163802	5.75E-39
THYM	Cell metabolism gene	RPL18A	FPGS	0.871830587	5.28E-39
THYM	Cell metabolism gene	RPL18A	EXOSC4	0.87716855	4.85E-40
THYM	Cell metabolism gene	RPL18A	PSMB3	0.877766281	3.69E-40
THYM	Cell metabolism gene	RPL18A	TOMM22	0.881877293	5.38E-41
THYM	Cell metabolism gene	RPL18A	EXOSC5	0.88299084	3.15E-41
THYM	Cell metabolism gene	RPL18A	SSR2	0.886222365	6.49E-42
THYM	Cell metabolism gene	RPL18A	ACOT8	0.887156686	4.07E-42
THYM	Cell metabolism gene	RPL18A	PSMB7	0.887671061	3.14E-42
THYM	Cell metabolism gene	RPL18A	POLD2	0.887977508	2.69E-42
THYM	Cell metabolism gene	RPL18A	LSM2	0.888180601	2.43E-42
THYM	Cell metabolism gene	RPL18A	TIMM8B	0.889657167	1.15E-42
THYM	Cell metabolism gene	RPL18A	PSMC3	0.896147816	3.68E-44
THYM	Cell metabolism gene	RPL18A	PGLS	0.901985668	1.37E-45
THYM	Cell metabolism gene	RPL18A	SLC27A5	0.905812754	1.41E-46
THYM	Cell metabolism gene	RPL18A	FAU	0.915270024	3.28E-49
THYM	Cell metabolism gene	RPL18A	TIMM13	0.924662984	3.77E-52
THYM	Cell metabolism gene	RPL18A	SNRPD2	0.931777211	1.22E-54
THYM	CGC	RPL18A	RBM10	0.854441376	6.36E-36
THYM	CGC	RPL18A	SDHAF2	0.89032239	8.13E-43
THYM	CGC	RPL18A	TFPT	0.899040729	7.37E-45
THYM	Epifactor	RPL18A	DMAP1	0.804556362	6.27E-29
THYM	Epifactor	RPL18A	SS18L2	0.806593943	3.57E-29
THYM	Epifactor	RPL18A	INO80E	0.820579911	6.17E-31
THYM	Epifactor	RPL18A	TRIM28	0.822367482	3.58E-31
THYM	Epifactor	RPL18A	PAF1	0.822853984	3.09E-31
THYM	Epifactor	RPL18A	PPM1G	0.830373752	2.90E-32
THYM	Epifactor	RPL18A	ZGPAT	0.831699759	1.89E-32
THYM	Epifactor	RPL18A	LAS1L	0.833731645	9.72E-33
THYM	Epifactor	RPL18A	CCDC101	0.834324418	7.99E-33
THYM	Epifactor	RPL18A	ZNHIT1	0.853964582	7.63E-36
THYM	Epifactor	RPL18A	PRMT1	0.854171496	7.05E-36
THYM	Epifactor	RPL18A	CXXC1	0.856181391	3.26E-36
THYM	Epifactor	RPL18A	RRP8	0.868822914	1.94E-38
THYM	Epifactor	RPL18A	SIRT6	0.868844782	1.92E-38
THYM	Epifactor	RPL18A	MBD3	0.869331577	1.56E-38
THYM	Epifactor	RPL18A	PPP4C	0.871576277	5.90E-39
THYM	Epifactor	RPL18A	RUVBL2	0.87570279	9.45E-40
THYM	Epifactor	RPL18A	EXOSC4	0.87716855	4.85E-40
THYM	Epifactor	RPL18A	C17orf49	0.882686559	3.65E-41
THYM	Epifactor	RPL18A	NOC2L	0.88298666	3.16E-41
THYM	Epifactor	RPL18A	EXOSC5	0.88299084	3.15E-41
THYM	Epifactor	RPL18A	PRPF31	0.885974862	7.33E-42
THYM	Epifactor	RPL18A	TFPT	0.899040729	7.37E-45
THYM	Epifactor	RPL18A	TAF10	0.905930125	1.31E-46
THYM	Epifactor	RPL18A	BRMS1	0.910001316	1.04E-47
THYM	Epifactor	RPL18A	FBL	0.939222447	1.48E-57
THYM	IUPHAR	RPL18A	PSMB6	0.800395686	1.94E-28
THYM	IUPHAR	RPL18A	RNPEPL1	0.801952896	1.28E-28
THYM	IUPHAR	RPL18A	PPIA	0.810276693	1.27E-29
THYM	IUPHAR	RPL18A	ORAI1	0.81222953	7.25E-30
THYM	IUPHAR	RPL18A	PHKG2	0.818061154	1.32E-30
THYM	IUPHAR	RPL18A	IMPDH2	0.819360102	8.92E-31
THYM	IUPHAR	RPL18A	TWF2	0.821033591	5.38E-31
THYM	IUPHAR	RPL18A	TRIM28	0.822367482	3.58E-31
THYM	IUPHAR	RPL18A	PSMB1	0.822679791	3.26E-31
THYM	IUPHAR	RPL18A	MFSD2B	0.828423622	5.42E-32
THYM	IUPHAR	RPL18A	SMPD2	0.847936379	7.15E-35
THYM	IUPHAR	RPL18A	MVD	0.851363292	2.03E-35
THYM	IUPHAR	RPL18A	PRMT1	0.854171496	7.05E-36
THYM	IUPHAR	RPL18A	EGLN2	0.85941367	9.23E-37
THYM	IUPHAR	RPL18A	SIRT6	0.868844782	1.92E-38
THYM	IUPHAR	RPL18A	SLC27A5	0.905812754	1.41E-46
THYM	Kinase	RPL18A	ADCK4	0.808643854	2.01E-29
THYM	Kinase	RPL18A	PHKG2	0.818061154	1.32E-30
THYM	Kinase	RPL18A	TRIM28	0.822367482	3.58E-31
THYM	TF	RPL18A	ZNF511	0.800747612	1.77E-28
THYM	TF	RPL18A	ZNF653	0.802603107	1.07E-28
THYM	TF	RPL18A	ZBTB17	0.816225528	2.27E-30
THYM	TF	RPL18A	USF2	0.817269476	1.66E-30
THYM	TF	RPL18A	DRAP1	0.817942661	1.36E-30
THYM	TF	RPL18A	RBCK1	0.818941177	1.01E-30
THYM	TF	RPL18A	SNAPC2	0.823342003	2.66E-31
THYM	TF	RPL18A	ETV2	0.82434313	1.95E-31
THYM	TF	RPL18A	IRF3	0.82517479	1.51E-31
THYM	TF	RPL18A	USF1	0.826432193	1.02E-31
THYM	TF	RPL18A	ZGPAT	0.831699759	1.89E-32
THYM	TF	RPL18A	REXO4	0.831841287	1.80E-32
THYM	TF	RPL18A	ZNF444	0.832545895	1.43E-32
THYM	TF	RPL18A	PIN1	0.839451339	1.42E-33
THYM	TF	RPL18A	THAP3	0.840547898	9.77E-34
THYM	TF	RPL18A	THYN1	0.841788512	6.36E-34
THYM	TF	RPL18A	ZNF668	0.848452784	5.93E-35
THYM	TF	RPL18A	ZNF688	0.850958625	2.36E-35
THYM	TF	RPL18A	ZNF787	0.852346329	1.40E-35
THYM	TF	RPL18A	CXXC1	0.856181391	3.26E-36
THYM	TF	RPL18A	ZNF428	0.867410969	3.52E-38
THYM	TF	RPL18A	MBD3	0.869331577	1.56E-38
THYM	TF	RPL18A	ZNF581	0.871470652	6.18E-39
THYM	TSG	RPL18A	GABARAP	0.816549946	2.06E-30
THYM	TSG	RPL18A	IRF3	0.82517479	1.51E-31
THYM	TSG	RPL18A	PARK7	0.838213745	2.17E-33
THYM	TSG	RPL18A	PIN1	0.839451339	1.42E-33
THYM	TSG	RPL18A	GADD45GIP1	0.841585164	6.83E-34
THYM	TSG	RPL18A	NPRL2	0.844013375	2.92E-34
THYM	TSG	RPL18A	AIP	0.845962664	1.46E-34
THYM	TSG	RPL18A	ZNF668	0.848452784	5.93E-35
THYM	TSG	RPL18A	PFN1	0.851270524	2.10E-35
THYM	TSG	RPL18A	SIRT6	0.868844782	1.92E-38
THYM	TSG	RPL18A	TSSC4	0.906542983	9.01E-47
THYM	TSG	RPL18A	BRMS1	0.910001316	1.04E-47
THYM	TSG	RPL18A	GLTSCR2	0.910074776	9.94E-48
THYM	TSG	RPL18A	GNB2L1	0.913754976	9.06E-49
UCS	Cell metabolism gene	RPL18A	PSMB6	0.800395686	1.94E-28
UCS	Cell metabolism gene	RPL18A	UROD	0.801215094	1.56E-28
UCS	Cell metabolism gene	RPL18A	MTMR14	0.802765941	1.02E-28
UCS	Cell metabolism gene	RPL18A	MTX1	0.803118755	9.30E-29
UCS	Cell metabolism gene	RPL18A	PSMB10	0.803119771	9.30E-29
UCS	Cell metabolism gene	RPL18A	DGUOK	0.803487675	8.41E-29
UCS	Cell metabolism gene	RPL18A	DPM3	0.803713853	7.90E-29
UCS	Cell metabolism gene	RPL18A	WBSCR22	0.806764502	3.40E-29
UCS	Cell metabolism gene	RPL18A	SNRPD1	0.817454246	1.58E-30
UCS	Cell metabolism gene	RPL18A	POLR2J	0.817659242	1.48E-30
UCS	Cell metabolism gene	RPL18A	PHKG2	0.818061154	1.32E-30
UCS	Cell metabolism gene	RPL18A	PGP	0.818288316	1.23E-30
UCS	Cell metabolism gene	RPL18A	PSMD4	0.818572003	1.13E-30
UCS	Cell metabolism gene	RPL18A	IDH3G	0.818905932	1.02E-30
UCS	Cell metabolism gene	RPL18A	IMPDH2	0.819360102	8.92E-31
UCS	Cell metabolism gene	RPL18A	TIMM17B	0.819935069	7.50E-31
UCS	Cell metabolism gene	RPL18A	DGKZ	0.820420436	6.48E-31
UCS	Cell metabolism gene	RPL18A	GALK1	0.821628466	4.49E-31
UCS	Cell metabolism gene	RPL18A	POLR3K	0.822478917	3.46E-31
UCS	Cell metabolism gene	RPL18A	POLD4	0.822534125	3.40E-31
UCS	Cell metabolism gene	RPL18A	PSMB1	0.822679791	3.26E-31
UCS	Cell metabolism gene	RPL18A	POLA2	0.822804841	3.13E-31
UCS	Cell metabolism gene	RPL18A	SEC61G	0.823194932	2.78E-31
UCS	Cell metabolism gene	RPL18A	TOMM40	0.823395832	2.61E-31
UCS	Cell metabolism gene	RPL18A	GCDH	0.825326377	1.44E-31
UCS	Cell metabolism gene	RPL18A	TIMM10	0.826807282	9.03E-32
UCS	Cell metabolism gene	RPL18A	LSM3	0.827039786	8.39E-32
UCS	Cell metabolism gene	RPL18A	TBCB	0.827045567	8.38E-32
UCS	Cell metabolism gene	RPL18A	PAFAH1B3	0.829357366	4.02E-32
UCS	Cell metabolism gene	RPL18A	OAZ1	0.829664154	3.64E-32
UCS	Cell metabolism gene	RPL18A	SNRPD3	0.833549914	1.03E-32
UCS	Cell metabolism gene	RPL18A	GMPPA	0.834888646	6.63E-33
UCS	Cell metabolism gene	RPL18A	NOP56	0.836006204	4.57E-33
UCS	Cell metabolism gene	RPL18A	SNRPE	0.836100503	4.43E-33
UCS	Cell metabolism gene	RPL18A	GEMIN7	0.839620198	1.34E-33
UCS	Cell metabolism gene	RPL18A	SNRPB	0.8406941	9.29E-34
UCS	Cell metabolism gene	RPL18A	NANS	0.840808465	8.93E-34
UCS	Cell metabolism gene	RPL18A	DPM2	0.841029503	8.28E-34
UCS	Cell metabolism gene	RPL18A	LSM4	0.845775019	1.56E-34
UCS	Cell metabolism gene	RPL18A	POLR2I	0.847404155	8.67E-35
UCS	Cell metabolism gene	RPL18A	SMPD2	0.847936379	7.15E-35
UCS	Cell metabolism gene	RPL18A	EBP	0.849877208	3.52E-35
UCS	Cell metabolism gene	RPL18A	MVD	0.851363292	2.03E-35
UCS	Cell metabolism gene	RPL18A	PMPCA	0.853078783	1.07E-35
UCS	Cell metabolism gene	RPL18A	TALDO1	0.853670336	8.53E-36
UCS	Cell metabolism gene	RPL18A	PFDN5	0.854091595	7.27E-36
UCS	Cell metabolism gene	RPL18A	HMBS	0.857002076	2.38E-36
UCS	Cell metabolism gene	RPL18A	POLR2H	0.859639883	8.44E-37
UCS	Cell metabolism gene	RPL18A	PSME1	0.861191573	4.54E-37
UCS	Cell metabolism gene	RPL18A	DTYMK	0.861393973	4.19E-37
UCS	Cell metabolism gene	RPL18A	APRT	0.86299963	2.19E-37
UCS	Cell metabolism gene	RPL18A	POLR2F	0.863833906	1.56E-37
UCS	Cell metabolism gene	RPL18A	SRM	0.868900335	1.87E-38
UCS	Cell metabolism gene	RPL18A	ITPA	0.868949799	1.83E-38
UCS	Cell metabolism gene	RPL18A	TIMM50	0.869985727	1.18E-38
UCS	Cell metabolism gene	RPL18A	GUK1	0.870892958	7.95E-39
UCS	Cell metabolism gene	RPL18A	PSMD13	0.87163802	5.75E-39
UCS	Cell metabolism gene	RPL18A	FPGS	0.871830587	5.28E-39
UCS	Cell metabolism gene	RPL18A	EXOSC4	0.87716855	4.85E-40
UCS	Cell metabolism gene	RPL18A	PSMB3	0.877766281	3.69E-40
UCS	Cell metabolism gene	RPL18A	TOMM22	0.881877293	5.38E-41
UCS	Cell metabolism gene	RPL18A	EXOSC5	0.88299084	3.15E-41
UCS	Cell metabolism gene	RPL18A	SSR2	0.886222365	6.49E-42
UCS	Cell metabolism gene	RPL18A	ACOT8	0.887156686	4.07E-42
UCS	Cell metabolism gene	RPL18A	PSMB7	0.887671061	3.14E-42
UCS	Cell metabolism gene	RPL18A	POLD2	0.887977508	2.69E-42
UCS	Cell metabolism gene	RPL18A	LSM2	0.888180601	2.43E-42
UCS	Cell metabolism gene	RPL18A	TIMM8B	0.889657167	1.15E-42
UCS	Cell metabolism gene	RPL18A	PSMC3	0.896147816	3.68E-44
UCS	Cell metabolism gene	RPL18A	PGLS	0.901985668	1.37E-45
UCS	Cell metabolism gene	RPL18A	SLC27A5	0.905812754	1.41E-46
UCS	Cell metabolism gene	RPL18A	FAU	0.915270024	3.28E-49
UCS	Cell metabolism gene	RPL18A	TIMM13	0.924662984	3.77E-52
UCS	Cell metabolism gene	RPL18A	SNRPD2	0.931777211	1.22E-54
UCS	CGC	RPL18A	RBM10	0.854441376	6.36E-36
UCS	CGC	RPL18A	SDHAF2	0.89032239	8.13E-43
UCS	CGC	RPL18A	TFPT	0.899040729	7.37E-45
UCS	Epifactor	RPL18A	DMAP1	0.804556362	6.27E-29
UCS	Epifactor	RPL18A	SS18L2	0.806593943	3.57E-29
UCS	Epifactor	RPL18A	INO80E	0.820579911	6.17E-31
UCS	Epifactor	RPL18A	TRIM28	0.822367482	3.58E-31
UCS	Epifactor	RPL18A	PAF1	0.822853984	3.09E-31
UCS	Epifactor	RPL18A	PPM1G	0.830373752	2.90E-32
UCS	Epifactor	RPL18A	ZGPAT	0.831699759	1.89E-32
UCS	Epifactor	RPL18A	LAS1L	0.833731645	9.72E-33
UCS	Epifactor	RPL18A	CCDC101	0.834324418	7.99E-33
UCS	Epifactor	RPL18A	ZNHIT1	0.853964582	7.63E-36
UCS	Epifactor	RPL18A	PRMT1	0.854171496	7.05E-36
UCS	Epifactor	RPL18A	CXXC1	0.856181391	3.26E-36
UCS	Epifactor	RPL18A	RRP8	0.868822914	1.94E-38
UCS	Epifactor	RPL18A	SIRT6	0.868844782	1.92E-38
UCS	Epifactor	RPL18A	MBD3	0.869331577	1.56E-38
UCS	Epifactor	RPL18A	PPP4C	0.871576277	5.90E-39
UCS	Epifactor	RPL18A	RUVBL2	0.87570279	9.45E-40
UCS	Epifactor	RPL18A	EXOSC4	0.87716855	4.85E-40
UCS	Epifactor	RPL18A	C17orf49	0.882686559	3.65E-41
UCS	Epifactor	RPL18A	NOC2L	0.88298666	3.16E-41
UCS	Epifactor	RPL18A	EXOSC5	0.88299084	3.15E-41
UCS	Epifactor	RPL18A	PRPF31	0.885974862	7.33E-42
UCS	Epifactor	RPL18A	TFPT	0.899040729	7.37E-45
UCS	Epifactor	RPL18A	TAF10	0.905930125	1.31E-46
UCS	Epifactor	RPL18A	BRMS1	0.910001316	1.04E-47
UCS	Epifactor	RPL18A	FBL	0.939222447	1.48E-57
UCS	IUPHAR	RPL18A	PSMB6	0.800395686	1.94E-28
UCS	IUPHAR	RPL18A	RNPEPL1	0.801952896	1.28E-28
UCS	IUPHAR	RPL18A	PPIA	0.810276693	1.27E-29
UCS	IUPHAR	RPL18A	ORAI1	0.81222953	7.25E-30
UCS	IUPHAR	RPL18A	PHKG2	0.818061154	1.32E-30
UCS	IUPHAR	RPL18A	IMPDH2	0.819360102	8.92E-31
UCS	IUPHAR	RPL18A	TWF2	0.821033591	5.38E-31
UCS	IUPHAR	RPL18A	TRIM28	0.822367482	3.58E-31
UCS	IUPHAR	RPL18A	PSMB1	0.822679791	3.26E-31
UCS	IUPHAR	RPL18A	MFSD2B	0.828423622	5.42E-32
UCS	IUPHAR	RPL18A	SMPD2	0.847936379	7.15E-35
UCS	IUPHAR	RPL18A	MVD	0.851363292	2.03E-35
UCS	IUPHAR	RPL18A	PRMT1	0.854171496	7.05E-36
UCS	IUPHAR	RPL18A	EGLN2	0.85941367	9.23E-37
UCS	IUPHAR	RPL18A	SIRT6	0.868844782	1.92E-38
UCS	IUPHAR	RPL18A	SLC27A5	0.905812754	1.41E-46
UCS	Kinase	RPL18A	ADCK4	0.808643854	2.01E-29
UCS	Kinase	RPL18A	PHKG2	0.818061154	1.32E-30
UCS	Kinase	RPL18A	TRIM28	0.822367482	3.58E-31
UCS	TF	RPL18A	ZNF511	0.800747612	1.77E-28
UCS	TF	RPL18A	ZNF653	0.802603107	1.07E-28
UCS	TF	RPL18A	ZBTB17	0.816225528	2.27E-30
UCS	TF	RPL18A	USF2	0.817269476	1.66E-30
UCS	TF	RPL18A	DRAP1	0.817942661	1.36E-30
UCS	TF	RPL18A	RBCK1	0.818941177	1.01E-30
UCS	TF	RPL18A	SNAPC2	0.823342003	2.66E-31
UCS	TF	RPL18A	ETV2	0.82434313	1.95E-31
UCS	TF	RPL18A	IRF3	0.82517479	1.51E-31
UCS	TF	RPL18A	USF1	0.826432193	1.02E-31
UCS	TF	RPL18A	ZGPAT	0.831699759	1.89E-32
UCS	TF	RPL18A	REXO4	0.831841287	1.80E-32
UCS	TF	RPL18A	ZNF444	0.832545895	1.43E-32
UCS	TF	RPL18A	PIN1	0.839451339	1.42E-33
UCS	TF	RPL18A	THAP3	0.840547898	9.77E-34
UCS	TF	RPL18A	THYN1	0.841788512	6.36E-34
UCS	TF	RPL18A	ZNF668	0.848452784	5.93E-35
UCS	TF	RPL18A	ZNF688	0.850958625	2.36E-35
UCS	TF	RPL18A	ZNF787	0.852346329	1.40E-35
UCS	TF	RPL18A	CXXC1	0.856181391	3.26E-36
UCS	TF	RPL18A	ZNF428	0.867410969	3.52E-38
UCS	TF	RPL18A	MBD3	0.869331577	1.56E-38
UCS	TF	RPL18A	ZNF581	0.871470652	6.18E-39
UCS	TSG	RPL18A	GABARAP	0.816549946	2.06E-30
UCS	TSG	RPL18A	IRF3	0.82517479	1.51E-31
UCS	TSG	RPL18A	PARK7	0.838213745	2.17E-33
UCS	TSG	RPL18A	PIN1	0.839451339	1.42E-33
UCS	TSG	RPL18A	GADD45GIP1	0.841585164	6.83E-34
UCS	TSG	RPL18A	NPRL2	0.844013375	2.92E-34
UCS	TSG	RPL18A	AIP	0.845962664	1.46E-34
UCS	TSG	RPL18A	ZNF668	0.848452784	5.93E-35
UCS	TSG	RPL18A	PFN1	0.851270524	2.10E-35
UCS	TSG	RPL18A	SIRT6	0.868844782	1.92E-38
UCS	TSG	RPL18A	TSSC4	0.906542983	9.01E-47
UCS	TSG	RPL18A	BRMS1	0.910001316	1.04E-47
UCS	TSG	RPL18A	GLTSCR2	0.910074776	9.94E-48
UCS	TSG	RPL18A	GNB2L1	0.913754976	9.06E-49
UVM	Cell metabolism gene	RPL18A	SLC27A5	0.808261132	1.27E-19
UVM	Cell metabolism gene	RPL18A	SLC25A6	0.815822081	3.08E-20
UVM	Cell metabolism gene	RPL18A	IMPDH2	0.823602408	6.69E-21
UVM	Cell metabolism gene	RPL18A	MPST	0.858623842	2.41E-24
UVM	Cell metabolism gene	RPL18A	PRKCSH	0.859694247	1.83E-24
UVM	Cell metabolism gene	RPL18A	SSR2	0.873132306	4.71E-26
UVM	Cell metabolism gene	RPL18A	FAU	0.907322101	4.41E-31
UVM	CGC	RPL18A	TRAF7	0.878060307	1.11E-26
UVM	Epifactor	RPL18A	TRIM28	0.892173731	1.20E-28
UVM	Epifactor	RPL18A	FBL	0.930147803	1.11E-35
UVM	IUPHAR	RPL18A	SLC27A5	0.808261132	1.27E-19
UVM	IUPHAR	RPL18A	SLC25A6	0.815822081	3.08E-20
UVM	IUPHAR	RPL18A	IMPDH2	0.823602408	6.69E-21
UVM	IUPHAR	RPL18A	MAP3K11	0.833457794	8.68E-22
UVM	IUPHAR	RPL18A	MPST	0.858623842	2.41E-24
UVM	IUPHAR	RPL18A	TRIM28	0.892173731	1.20E-28
UVM	Kinase	RPL18A	MAP3K11	0.833457794	8.68E-22
UVM	Kinase	RPL18A	TRIM28	0.892173731	1.20E-28
UVM	TF	RPL18A	ZNF524	0.802009871	3.90E-19
UVM	TF	RPL18A	FIZ1	0.802846942	3.36E-19
UVM	TF	RPL18A	USF2	0.808059027	1.32E-19
UVM	TF	RPL18A	REXO4	0.809933021	9.32E-20
UVM	TF	RPL18A	WIZ	0.812858014	5.40E-20
UVM	TF	RPL18A	ZNF581	0.912648607	4.86E-32
UVM	TSG	RPL18A	GLTSCR2	0.878786315	8.89E-27
UVM	TSG	RPL18A	GNB2L1	0.881903629	3.42E-27

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	RPL18A	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL18A	RPS16	-1.35957043617517	0.00019507110118866
STAD	RPL18A	RPS23	1.85076760664576	0.000364991836249828
COAD	RPL18A	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL18A	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL18A	RPL8	-4.84588284974558	0.00110314154326131
KICH	RPL18A	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL18A	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL18A	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL18A	RPS16	-6.16322798156577	0.0115764821363307
LUSC	RPL18A	RPS23	1.46751169891047	0.0174932185880974
BLCA	RPL18A	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL18A	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL18A	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL18A	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL18A	RPL19	-2.14669889516666	0.044366810398747
UCEC	RPL18A	RPS23	-2.03658159814007	0.046875
KIRC	RPL18A	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL18A	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL18A	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL18A	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL18A	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL18A	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL18A	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL18A	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL18A	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL18A	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL18A	RPS3	-1.29560847926387	9.05905681935088e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL18A

DDX56, PSTPIP1, LYAR, RTCA, RIBC2, LPL, MDK, RPL36, NOP56, VHL, SIRT7, CUL1, COPS5, CAND1, RNF115, RPL10A, RPL11, RPL12, RPL14, RPL18, RPL19, RPL21, RPL23A, RPL23, RPL24, RPL30, RPL31, RPL3, RPL4, RPL5, RPL6, RPL7A, RPL7, RPL8, RPL9, RPS11, RPS12, RPS15A, RPS16, RPS19, RPS20, RPS23, RPS26, RPS2, RPS3A, RPS3, RPS4X, RPS5, RPS6, RPS7, RPS8, RPSA, RPS24, RPL15, RPS13, RPL37A, RPS14, RPL22, RPLP0, RPL17, RPS27A, RPS21, RPL32, EEF1A1, EIF6, FBL, GNL3, NCL, ILF3, HNRNPU, NHP2L1, NOP58, U2AF2, NOLC1, LUC7L2, HNRNPM, RPLP0P6, FTSJ3, RRS1, RPS10P5, RPL10L, NIFK, NOP2, TPR, DIDO1, HSPA8, SUB1, ESR1, PA2G4, UBL4A, SF3B1, PAN2, TARDBP, CAPZA2, RPA3, RPA2, RPA1, CEP250, TP53, TUBG1, TUBGCP4, VCP, EED, RNF2, UBC, THAP7, BRIX1, DDX27, NOC2L, PES1, RPL10, RPL13, RPL13A, DDX18, PABPC1, PABPC4, RPLP2, RPS15, RPS27, RPL27, RPL27A, RPL35, RPL35A, RPL38, RPL3L, RPLP1, RPS10, RPS18, RPS25, LOC101929876, RPS9, SF3B3, UBA52, KRAS, XPO1, NPM1, EXOSC4, CBX8, Eif3a, Eif3e, Ktn1, Rpl35, Srp72, Rrbp1, Brwd3, MCM2, NF2, Ksr1, KIAA0020, TAF1D, TSPYL2, PDCD11, RRP8, CENPU, URB1, DDX24, CEBPZ, RRP7A, WDR36, TAF1C, CNBP, PPAN-P2RY11, DDX31, RPL28, NOC3L, ZNF689, ZC3HAV1, DDX54, REXO4, TRMT1L, DHX30, RBM28, GNL2, SRBD1, DDX51, TTF1, GLTSCR2, NOL6, BMS1, NGDN, TSPYL1, SRP68, POP4, BBX, DDX10, RPF1, C8orf33, ZCCHC6, PRR11, C3orf17, NSA2, IMP4, EXOSC10, NAT10, SDAD1, RBM34, RSBN1, GLYR1, MYBBP1A, YTHDC2, STAU1, URB2, DHX8, ZNF71, RFC1, MAGEB10, PATZ1, GTPBP4, SRRM1, PRDM5, EBNA1BP2, RBM4, DKC1, CPNE4, PRKRA, MINA, RRP1B, PTP4A2, PTPN6, CYLD, INO80B, TRIM25, BRCA1, MTF1, PPP1CC, BMP4, CTNNB1, PCBP1, CUL4B, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, RNF4, CHD4, RIOK1, MEPCE, LARP7, SNAI1, RECQL4, REST, MYC, CDK9, Prkaa1, Prkab1, GRWD1, METTL14, RC3H1, RC3H2, PHB, KIN, NR2C2, GBF1, CTCF, VRK1, VRK3, HIST1H4A, SNRNP70, Dppa3, ITFG1, HMGB1, BIRC3, NFX1, WWP2, SOX2, CMTR1, PLEKHA4, FANCD2, PTEN, HCVgp1, ZC3H18, MAP3K14, RAB5A, WNT8B, F8, E, M, nsp12, nsp13, nsp14, nsp4, nsp5, nsp6, nsp8, ORF3a, ORF6, ORF7a, ORF7b, ORF8, S, nsp3, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, GRSF1, LRRC59, INS, NDN, BRD4, UCHL1, Apc2, RBM39, FBP1, LGALS9, RIN3, DNAJC2, DNAJC11, DNAJC19, DNAJC5B, AR, PARK2, UFL1, DDRGK1, COIL, DHFRL1, GJD3, MARCKS, PANX1, PTK2, SYNE3, TRIM37, USP15, HTRA4, FZR1, WDR5, PAGE4, NAA40, SRSF6, PRPF4B, DDX21, ZNF770, RSL1D1, ADARB1, MAGEB2, TEX10, CCDC140, GZF1, ZNF48, SRSF5, PAPD5, KCTD5, SRSF1, DICER1, ZNF22, CCDC137, PUSL1, NOL12, KNOP1, ZNF512, GPATCH4, HIST1H1A, RPL26L1, DDX50, SRPK2, TUBB2B, RPL36AL, PPP4R2, SURF6, C7orf50, BCL7B, NIP7, CCDC59, NOP16, VPRBP, SMEK1, PAK1IP1, MPHOSPH10, ZNF668, ZC3H3, BTF3, FBXW7, NLRP7, RCHY1, N, KLF16, KLF4,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL18A	UCEC	chr19	17972156	17972156	C	A	Missense_Mutation	p.P25T	3
RPL18A	ESCA	chr19	17972276	17972276	G	T	Missense_Mutation	p.G65W	3
RPL18A	BRCA	chr19	17974037	17974037	C	T	Missense_Mutation	p.R166C	3
RPL18A	SKCM	chr19	17972140	17972140	C	T	Silent	p.T19T	2
RPL18A	SKCM	chr19	17972151	17972151	A	C	Missense_Mutation	p.H23P	2
RPL18A	UCEC	chr19	17972175	17972175	G	A	Missense_Mutation	p.R31Q	2
RPL18A	SKCM	chr19	17972995	17972995	C	T	Silent	p.Y97Y	2
RPL18A	UCEC	chr19	17973794	17973794	C	T	Silent	p.I132	2
RPL18A	LIHC	chr19	17973742	17973742	C	-	Frame_Shift_Del	p.A115fs	2
RPL18A	SKCM	chr19	17972996	17972996	C	T	Missense_Mutation	p.R98W	2
RPL18A	KICH	chr19	17972198	17972198	G	A	Missense_Mutation	p.V39I	2
RPL18A	BLCA	chr19	17972200	17972200	C	A	Silent	p.V39V	2
RPL18A	KIRC	chr19	17972160	17972160	C	A	Missense_Mutation	p.P26H	2
RPL18A	BRCA	chr19	17972952	17972952	G	A	Missense_Mutation	p.R83H	2
RPL18A	COAD	chr19	17973797	17973797	G	A	Silent	p.A133A	1
RPL18A	LGG	chr19	17972951	17972951	C	T	Missense_Mutation		1
RPL18A	COAD	chr19	17974063	17974065	CTT	-	In_Frame_Del	p.174_175del	1
RPL18A	LIHC	chr19	17972267	17972267	G	T	Missense_Mutation	p.V62F	1
RPL18A	ESCA	chr19	17972276	17972276	G	T	Missense_Mutation		1
RPL18A	LIHC	chr19	17973829	17973829	A	T	Missense_Mutation	p.Q144L	1
RPL18A	SKCM	chr19	17973025	17973025	C	T	Silent	p.T107T	1
RPL18A	GBM	chr19	17972168	17972168	C	T	Missense_Mutation		1
RPL18A	LUAD	chr19	17973773	17973773	G	A	Silent	p.Q125Q	1
RPL18A	SKCM	chr19	17972917	17972917	C	T	Silent	p.S71S	1
RPL18A	HNSC	chr19	17972909	17972909	G	C	Missense_Mutation		1
RPL18A	PAAD	chr19	17973031	17973031	C	A	Nonsense_Mutation	p.C109X	1
RPL18A	SKCM	chr19	17972916	17972916	C	T	Missense_Mutation	p.S71F	1
RPL18A	HNSC	chr19	17972909	17972909	G	C	Missense_Mutation	p.E69Q	1
RPL18A	PAAD	chr19	17973031	17973031	C	A	Splice_Site	p.C109_splice	1
RPL18A	STAD	chr19	17973010	17973010	C	A	Silent	p.T102T	1
RPL18A	PAAD	chr19	17973031	17973031	C	A	Splice_Site	p.C109*	1
RPL18A	THCA	chr19	17973820	17973820	C	T	Missense_Mutation	p.A141V	1
RPL18A	PAAD	chr19	17973031	17973031	C	A	Nonsense_Mutation		1
RPL18A	THCA	chr19	17973820	17973820	C	T	Missense_Mutation	p.A112V	1
RPL18A	KIRP	chr19	17974057	17974058	-	A	Frame_Shift_Ins	p.P172fs	1
RPL18A	PRAD	chr19	17973016	17973016	C	T	Silent	p.G104G	1
RPL18A	THYM	chr19	17972990	17972990	G	T	Nonsense_Mutation		1
RPL18A	LGG	chr19	17972951	17972951	C	T	Missense_Mutation	p.R83C	1

Copy number variation (CNV) of RPL18A
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL18A
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
95632	N/A	CA487209	KLK3	chr19	51363439	+	RPL18A	chr19	17971000	+
95632	COAD	TCGA-AA-A03F-01A	MYL12B	chr18	3277324	+	RPL18A	chr19	17973002	+
102196	OV	TCGA-29-1694	RPL18A	chr19	17970783	+	FCHO1	chr19	17865125	+
102196	OV	TCGA-29-1694	RPL18A	chr19	17970783	+	FCHO1	chr19	17873570	+
90842	BRCA	TCGA-AN-A0FD-01A	RPL18A	chr19	17973032	+	HELZ	chr17	65142006	-
103091	OV	TCGA-09-1665	RPL18A	chr19	17970783	+	SSBP4	chr19	18538160	+
101559	N/A	EC462734	RPL18A	chr19	17974123	+	UBR7	chr14	93689918	-
95632	STAD	TCGA-F1-A72C	SH3PXD2B	chr5	171833280	-	RPL18A	chr19	17973726	+
95632	OV	TCGA-20-0991-01A	TPM4	chr19	16199930	+	RPL18A	chr19	17972102	+
95640	N/A	BF526896	TXNRD1	chr12	104659624	+	RPL18A	chr19	17972101	+
95640	N/A	BG056715	TXNRD1	chr12	104659672	-	RPL18A	chr19	17974125	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPL18A	0.000473579071446854	0.013
SARC	RPL18A	0.0146778314646685	0.4
COAD	RPL18A	0.0336482532309309	0.87

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL18A	0.000533670395907315	0.018
BRCA	RPL18A	0.000614685750332116	0.02
PRAD	RPL18A	0.0375376468033873	1
PAAD	RPL18A	0.0147619829265802	0.46
THYM	RPL18A	0.035089755889499	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source