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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL24 (NCBI Gene ID:6152)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL24
	Gene ID: 6152
	Gene Symbol	RPL24
	Gene ID	6152
	Gene Name	ribosomal protein L24
	Synonyms	HEL-S-310\|L24
	Cytomap	3q12.3
	Type of Gene	protein-coding
	Description	60S ribosomal protein L2460S ribosomal protein L30epididymis secretory protein Li 310large ribosomal subunit protein eL24ribosomal protein L30
	Modification date	20200320
	UniProtAcc	P83731

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPL24	GO:0002181	cytoplasmic translation	25957688

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL24	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL24[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL24	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000394077	101401272	101401336	Frame-shift
ENST00000394077	101404661	101404772	In-frame
ENST00000394077	101405325	101405401	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000394077	101404661	101404772	640	188	298	157	27	64

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P83731	27	64	1	157	Chain	ID=PRO_0000136867;Note=60S ribosomal protein L24
P83731	27	64	27	27	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19608861;Dbxref=PMID:19608861
P83731	27	64	27	27	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
P83731	27	64	35	35	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
THCA	RPL24	1.06284306986844	0.000144459266043069
KIRC	RPL24	-2.29123283250518	9.9540413319149e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
HNSC	RPL24	1	2	0.0378919302958234	0.188789032258065	0.269373096539162	0.0280727816443103	-0.139388379410985

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
CHOL	RPL24	0.082205112	0.01281035
STAD	RPL24	-0.045967014	0.042546216

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL24 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	RPL24	LSM3	0.804726157	5.50E-12
DLBC	Cell metabolism gene	RPL24	ATP5G1	0.806140329	4.73E-12
DLBC	Cell metabolism gene	RPL24	POLR2L	0.807623	4.03E-12
DLBC	Cell metabolism gene	RPL24	PHPT1	0.810045239	3.10E-12
DLBC	Cell metabolism gene	RPL24	SEC61G	0.810986566	2.79E-12
DLBC	Cell metabolism gene	RPL24	PGLS	0.813681312	2.07E-12
DLBC	Cell metabolism gene	RPL24	TOMM22	0.814469672	1.90E-12
DLBC	Cell metabolism gene	RPL24	DPM2	0.82441794	5.98E-13
DLBC	Cell metabolism gene	RPL24	TOMM7	0.827227706	4.26E-13
DLBC	Cell metabolism gene	RPL24	POLR2J	0.827293847	4.23E-13
DLBC	Cell metabolism gene	RPL24	PSMD13	0.83018935	2.96E-13
DLBC	Cell metabolism gene	RPL24	PMPCA	0.832001887	2.36E-13
DLBC	Cell metabolism gene	RPL24	PSMC5	0.84055609	7.83E-14
DLBC	Cell metabolism gene	RPL24	ECHS1	0.841614042	6.80E-14
DLBC	Cell metabolism gene	RPL24	DGUOK	0.8437457	5.10E-14
DLBC	Cell metabolism gene	RPL24	PSMB3	0.845661779	3.93E-14
DLBC	Cell metabolism gene	RPL24	GFER	0.847459253	3.06E-14
DLBC	Cell metabolism gene	RPL24	POLR2I	0.852139917	1.58E-14
DLBC	Cell metabolism gene	RPL24	GEMIN7	0.853569582	1.28E-14
DLBC	Cell metabolism gene	RPL24	TIMM13	0.855659013	9.42E-15
DLBC	Cell metabolism gene	RPL24	POLR2F	0.857414134	7.25E-15
DLBC	Cell metabolism gene	RPL24	TIMM9	0.874783927	4.44E-16
DLBC	Cell metabolism gene	RPL24	NME2	0.876724622	3.17E-16
DLBC	Cell metabolism gene	RPL24	PFDN5	0.898357008	4.77E-18
DLBC	Cell metabolism gene	RPL24	SNRPD2	0.913681605	1.32E-19
DLBC	Cell metabolism gene	RPL24	FAU	0.91430084	1.12E-19
DLBC	CGC	RPL24	NACA	0.827102856	4.33E-13
DLBC	Epifactor	RPL24	RBX1	0.800238369	8.80E-12
DLBC	Epifactor	RPL24	MBD3	0.806062471	4.77E-12
DLBC	Epifactor	RPL24	PRPF31	0.80641011	4.59E-12
DLBC	Epifactor	RPL24	DMAP1	0.830782544	2.75E-13
DLBC	Epifactor	RPL24	ZNHIT1	0.834779917	1.66E-13
DLBC	Epifactor	RPL24	FBL	0.873272283	5.76E-16
DLBC	IUPHAR	RPL24	SIRT3	0.808319311	3.74E-12
DLBC	IUPHAR	RPL24	MMP24	0.809088553	3.44E-12
DLBC	IUPHAR	RPL24	SLC25A26	0.868111102	1.36E-15
DLBC	TF	RPL24	MBD3	0.806062471	4.77E-12
DLBC	TF	RPL24	ZNF428	0.810472941	2.95E-12
DLBC	TF	RPL24	THAP3	0.812942592	2.25E-12
DLBC	TF	RPL24	THAP4	0.824527497	5.90E-13
DLBC	TF	RPL24	ZNF444	0.835654524	1.49E-13
DLBC	TF	RPL24	THAP7	0.838367782	1.04E-13
DLBC	TF	RPL24	NME2	0.876724622	3.17E-16
DLBC	TSG	RPL24	SIRT3	0.808319311	3.74E-12
DLBC	TSG	RPL24	GLTSCR2	0.809596678	3.25E-12
DLBC	TSG	RPL24	PARK7	0.816376984	1.53E-12
DLBC	TSG	RPL24	GNB2L1	0.874196339	4.92E-16
DLBC	TSG	RPL24	GADD45GIP1	0.877718911	2.66E-16
GBM	Cell metabolism gene	RPL24	SUCLG1	0.802467557	5.73E-40
GBM	Cell metabolism gene	RPL24	LSM3	0.804640692	2.47E-40
GBM	Cell metabolism gene	RPL24	PSMB4	0.811650069	1.53E-41
GBM	Cell metabolism gene	RPL24	PSMA5	0.817783968	1.21E-42
GBM	Cell metabolism gene	RPL24	FAU	0.82213814	1.89E-43
GBM	Cell metabolism gene	RPL24	SNRPG	0.825206528	4.95E-44
GBM	Cell metabolism gene	RPL24	PFDN5	0.844980623	4.47E-48
GBM	Epifactor	RPL24	DPY30	0.80445793	2.66E-40
GBM	TSG	RPL24	GAS5	0.821746712	2.24E-43
KICH	Cell metabolism gene	RPL24	SNRPD2	0.812933373	1.30E-22
KICH	Epifactor	RPL24	SS18L2	0.837295568	4.62E-25
KIRP	Cell metabolism gene	RPL24	PFDN5	0.80386094	2.09E-74
KIRP	Cell metabolism gene	RPL24	SNRPD2	0.847612721	2.37E-90
KIRP	Cell metabolism gene	RPL24	FAU	0.854756833	1.96E-93
LAML	CGC	RPL24	NACA	0.823565395	5.75E-44
LGG	Cell metabolism gene	RPL24	FAU	0.886382709	9.91E-179
LGG	CGC	RPL24	NACA	0.861542432	1.44E-157
LGG	TSG	RPL24	GNB2L1	0.81999491	4.79E-130
LGG	TSG	RPL24	GAS5	0.820372004	2.90E-130
LIHC	Cell metabolism gene	RPL24	FAU	0.820280449	3.36E-104
LIHC	Cell metabolism gene	RPL24	PFDN5	0.842952678	2.08E-115
PAAD	Cell metabolism gene	RPL24	FAU	0.828281003	2.09E-47
PRAD	Cell metabolism gene	RPL24	SNRPE	0.804321246	5.49E-126
PRAD	Cell metabolism gene	RPL24	ZNRD1	0.807414093	1.11E-127
PRAD	Cell metabolism gene	RPL24	TOMM7	0.81195699	3.17E-130
PRAD	Cell metabolism gene	RPL24	PFDN5	0.815965078	1.58E-132
PRAD	Cell metabolism gene	RPL24	PSMB7	0.826250186	1.05E-138
PRAD	Cell metabolism gene	RPL24	POLR2I	0.830525992	2.15E-141
PRAD	Cell metabolism gene	RPL24	NME2	0.83381897	1.62E-143
PRAD	Cell metabolism gene	RPL24	POLR2F	0.834429512	6.47E-144
PRAD	Cell metabolism gene	RPL24	TIMM9	0.859379907	9.33E-162
PRAD	Cell metabolism gene	RPL24	SNRPD2	0.884282409	2.22E-183
PRAD	Cell metabolism gene	RPL24	FAU	0.891230616	2.59E-190
PRAD	CGC	RPL24	NACA	0.88454501	1.24E-183
PRAD	Epifactor	RPL24	FBL	0.868265996	5.82E-169
PRAD	TF	RPL24	NME2	0.83381897	1.62E-143
PRAD	TSG	RPL24	GADD45GIP1	0.801146048	2.80E-124
PRAD	TSG	RPL24	GAS5	0.816280797	1.03E-132
PRAD	TSG	RPL24	GNB2L1	0.873111667	4.08E-173
TGCT	Cell metabolism gene	RPL24	PSMB3	0.803719067	1.50E-36
TGCT	Cell metabolism gene	RPL24	PFDN4	0.808790083	2.47E-37
TGCT	Cell metabolism gene	RPL24	NIT2	0.810681374	1.24E-37
TGCT	Cell metabolism gene	RPL24	GEMIN7	0.818453464	6.80E-39
TGCT	Cell metabolism gene	RPL24	NT5C	0.822285981	1.54E-39
TGCT	Epifactor	RPL24	ZNHIT1	0.821139361	2.41E-39
TGCT	IUPHAR	RPL24	CSNK2B	0.806763524	5.12E-37
TGCT	IUPHAR	RPL24	NT5C	0.822285981	1.54E-39
TGCT	IUPHAR	RPL24	PPIA	0.823997341	7.84E-40
TGCT	TSG	RPL24	NIT2	0.810681374	1.24E-37
THCA	Cell metabolism gene	RPL24	PFDN6	0.80534977	1.50E-131
THCA	Cell metabolism gene	RPL24	DPM3	0.81205638	1.95E-135
THCA	Cell metabolism gene	RPL24	DGUOK	0.833149462	9.50E-149
THCA	Cell metabolism gene	RPL24	POLR2I	0.851720644	4.08E-162
THCA	Cell metabolism gene	RPL24	SNRPD2	0.871038456	4.06E-178
THCA	Cell metabolism gene	RPL24	PFDN5	0.875319507	5.13E-182
THCA	Cell metabolism gene	RPL24	FAU	0.895787663	7.05E-203
THCA	Epifactor	RPL24	TAF10	0.845148827	3.48E-157
THCA	IUPHAR	RPL24	CSNK2B	0.818806067	1.66E-139
THCA	TF	RPL24	ZNF524	0.807416216	9.87E-133
THCA	TSG	RPL24	AIP	0.805239816	1.73E-131
THCA	TSG	RPL24	GADD45GIP1	0.833271285	7.86E-149
THYM	Cell metabolism gene	RPL24	PHKG2	0.801063636	1.62E-28
THYM	Cell metabolism gene	RPL24	NT5C	0.801418954	1.47E-28
THYM	Cell metabolism gene	RPL24	MVD	0.802969502	9.69E-29
THYM	Cell metabolism gene	RPL24	PSMC5	0.804569711	6.25E-29
THYM	Cell metabolism gene	RPL24	PSMC1	0.806775694	3.39E-29
THYM	Cell metabolism gene	RPL24	SNRPF	0.80977156	1.46E-29
THYM	Cell metabolism gene	RPL24	ITPA	0.810325	1.25E-29
THYM	Cell metabolism gene	RPL24	SMPD2	0.812680948	6.37E-30
THYM	Cell metabolism gene	RPL24	B3GAT3	0.820247682	6.82E-31
THYM	Cell metabolism gene	RPL24	PFDN6	0.823612144	2.44E-31
THYM	Cell metabolism gene	RPL24	DGUOK	0.824101862	2.10E-31
THYM	Cell metabolism gene	RPL24	LCMT1	0.825708012	1.27E-31
THYM	Cell metabolism gene	RPL24	DPM3	0.825795949	1.24E-31
THYM	Cell metabolism gene	RPL24	IDH3G	0.826104833	1.13E-31
THYM	Cell metabolism gene	RPL24	GFER	0.832118862	1.65E-32
THYM	Cell metabolism gene	RPL24	LSM2	0.835531482	5.35E-33
THYM	Cell metabolism gene	RPL24	TIMM50	0.835885781	4.76E-33
THYM	Cell metabolism gene	RPL24	ACOT8	0.836930649	3.35E-33
THYM	Cell metabolism gene	RPL24	PGLS	0.839111619	1.60E-33
THYM	Cell metabolism gene	RPL24	UROD	0.841134486	7.98E-34
THYM	Cell metabolism gene	RPL24	APRT	0.843084354	4.04E-34
THYM	Cell metabolism gene	RPL24	PSMB3	0.846771433	1.09E-34
THYM	Cell metabolism gene	RPL24	TIMM13	0.847275365	9.09E-35
THYM	Cell metabolism gene	RPL24	POLR2J	0.847304943	8.99E-35
THYM	Cell metabolism gene	RPL24	POLR2F	0.847793347	7.53E-35
THYM	Cell metabolism gene	RPL24	POLR2I	0.848553575	5.71E-35
THYM	Cell metabolism gene	RPL24	PSMC3	0.849841736	3.56E-35
THYM	Cell metabolism gene	RPL24	PSMD13	0.849968664	3.40E-35
THYM	Cell metabolism gene	RPL24	SNRPD3	0.852564208	1.29E-35
THYM	Cell metabolism gene	RPL24	POLR2H	0.856329922	3.08E-36
THYM	Cell metabolism gene	RPL24	PSMB1	0.859405473	9.26E-37
THYM	Cell metabolism gene	RPL24	PSMB7	0.869878745	1.23E-38
THYM	Cell metabolism gene	RPL24	DPM2	0.869913925	1.21E-38
THYM	Cell metabolism gene	RPL24	SSR2	0.877924327	3.43E-40
THYM	Cell metabolism gene	RPL24	SLC27A5	0.885768253	8.12E-42
THYM	Cell metabolism gene	RPL24	SNRPD2	0.891430679	4.57E-43
THYM	Cell metabolism gene	RPL24	TIMM8B	0.89491851	7.17E-44
THYM	Cell metabolism gene	RPL24	PFDN5	0.928625317	1.66E-53
THYM	Cell metabolism gene	RPL24	FAU	0.949781323	2.16E-62
THYM	CGC	RPL24	MGMT	0.807031486	3.16E-29
THYM	CGC	RPL24	TFPT	0.826010894	1.16E-31
THYM	CGC	RPL24	RBM10	0.827966782	6.26E-32
THYM	Epifactor	RPL24	NOC2L	0.804396447	6.56E-29
THYM	Epifactor	RPL24	MBD3	0.80922451	1.71E-29
THYM	Epifactor	RPL24	RUVBL2	0.81178212	8.25E-30
THYM	Epifactor	RPL24	PPP4C	0.816489725	2.10E-30
THYM	Epifactor	RPL24	TFPT	0.826010894	1.16E-31
THYM	Epifactor	RPL24	SS18L2	0.828646306	5.04E-32
THYM	Epifactor	RPL24	C17orf49	0.834735891	6.97E-33
THYM	Epifactor	RPL24	PRPF31	0.839575234	1.37E-33
THYM	Epifactor	RPL24	INO80E	0.840903387	8.64E-34
THYM	Epifactor	RPL24	CCDC101	0.845844925	1.52E-34
THYM	Epifactor	RPL24	BRMS1	0.857189432	2.21E-36
THYM	Epifactor	RPL24	DMAP1	0.86104821	4.81E-37
THYM	Epifactor	RPL24	ZNHIT1	0.863880906	1.53E-37
THYM	Epifactor	RPL24	FBL	0.872358298	4.19E-39
THYM	Epifactor	RPL24	SIRT6	0.877016751	5.20E-40
THYM	Epifactor	RPL24	TAF10	0.887984519	2.68E-42
THYM	IUPHAR	RPL24	PHKG2	0.801063636	1.62E-28
THYM	IUPHAR	RPL24	NT5C	0.801418954	1.47E-28
THYM	IUPHAR	RPL24	CSNK2B	0.802518051	1.10E-28
THYM	IUPHAR	RPL24	MVD	0.802969502	9.69E-29
THYM	IUPHAR	RPL24	SMPD2	0.812680948	6.37E-30
THYM	IUPHAR	RPL24	SIRT3	0.823604919	2.45E-31
THYM	IUPHAR	RPL24	MMP24	0.844564641	2.40E-34
THYM	IUPHAR	RPL24	PSMB1	0.859405473	9.26E-37
THYM	IUPHAR	RPL24	SIRT6	0.877016751	5.20E-40
THYM	IUPHAR	RPL24	SLC27A5	0.885768253	8.12E-42
THYM	Kinase	RPL24	PHKG2	0.801063636	1.62E-28
THYM	TF	RPL24	ZNF444	0.801864835	1.31E-28
THYM	TF	RPL24	ZNF580	0.80300613	9.59E-29
THYM	TF	RPL24	AKAP8L	0.807526201	2.75E-29
THYM	TF	RPL24	MBD3	0.80922451	1.71E-29
THYM	TF	RPL24	DRAP1	0.817452869	1.58E-30
THYM	TF	RPL24	THAP7	0.819872649	7.64E-31
THYM	TF	RPL24	THYN1	0.8258022	1.24E-31
THYM	TF	RPL24	ZNF787	0.851099388	2.24E-35
THYM	TF	RPL24	ZNF32	0.861864818	3.47E-37
THYM	TF	RPL24	ZNF428	0.872575663	3.81E-39
THYM	TF	RPL24	THAP3	0.879870487	1.39E-40
THYM	TSG	RPL24	HTRA2	0.807331505	2.91E-29
THYM	TSG	RPL24	SIRT3	0.823604919	2.45E-31
THYM	TSG	RPL24	GABARAP	0.828045823	6.11E-32
THYM	TSG	RPL24	GLTSCR2	0.832782368	1.33E-32
THYM	TSG	RPL24	PARK7	0.838979604	1.67E-33
THYM	TSG	RPL24	NPRL2	0.847873194	7.32E-35
THYM	TSG	RPL24	TSSC4	0.851040722	2.29E-35
THYM	TSG	RPL24	BRMS1	0.857189432	2.21E-36
THYM	TSG	RPL24	GADD45GIP1	0.871212442	6.92E-39
THYM	TSG	RPL24	SIRT6	0.877016751	5.20E-40
THYM	TSG	RPL24	GNB2L1	0.897940794	1.37E-44
UCEC	Cell metabolism gene	RPL24	PFDN5	0.830708372	1.63E-52
UCEC	Cell metabolism gene	RPL24	FAU	0.844851505	5.85E-56
UCS	Cell metabolism gene	RPL24	PHKG2	0.801063636	1.62E-28
UCS	Cell metabolism gene	RPL24	NT5C	0.801418954	1.47E-28
UCS	Cell metabolism gene	RPL24	MVD	0.802969502	9.69E-29
UCS	Cell metabolism gene	RPL24	PSMC5	0.804569711	6.25E-29
UCS	Cell metabolism gene	RPL24	PSMC1	0.806775694	3.39E-29
UCS	Cell metabolism gene	RPL24	SNRPF	0.80977156	1.46E-29
UCS	Cell metabolism gene	RPL24	ITPA	0.810325	1.25E-29
UCS	Cell metabolism gene	RPL24	SMPD2	0.812680948	6.37E-30
UCS	Cell metabolism gene	RPL24	B3GAT3	0.820247682	6.82E-31
UCS	Cell metabolism gene	RPL24	PFDN6	0.823612144	2.44E-31
UCS	Cell metabolism gene	RPL24	DGUOK	0.824101862	2.10E-31
UCS	Cell metabolism gene	RPL24	LCMT1	0.825708012	1.27E-31
UCS	Cell metabolism gene	RPL24	DPM3	0.825795949	1.24E-31
UCS	Cell metabolism gene	RPL24	IDH3G	0.826104833	1.13E-31
UCS	Cell metabolism gene	RPL24	GFER	0.832118862	1.65E-32
UCS	Cell metabolism gene	RPL24	LSM2	0.835531482	5.35E-33
UCS	Cell metabolism gene	RPL24	TIMM50	0.835885781	4.76E-33
UCS	Cell metabolism gene	RPL24	ACOT8	0.836930649	3.35E-33
UCS	Cell metabolism gene	RPL24	PGLS	0.839111619	1.60E-33
UCS	Cell metabolism gene	RPL24	UROD	0.841134486	7.98E-34
UCS	Cell metabolism gene	RPL24	APRT	0.843084354	4.04E-34
UCS	Cell metabolism gene	RPL24	PSMB3	0.846771433	1.09E-34
UCS	Cell metabolism gene	RPL24	TIMM13	0.847275365	9.09E-35
UCS	Cell metabolism gene	RPL24	POLR2J	0.847304943	8.99E-35
UCS	Cell metabolism gene	RPL24	POLR2F	0.847793347	7.53E-35
UCS	Cell metabolism gene	RPL24	POLR2I	0.848553575	5.71E-35
UCS	Cell metabolism gene	RPL24	PSMC3	0.849841736	3.56E-35
UCS	Cell metabolism gene	RPL24	PSMD13	0.849968664	3.40E-35
UCS	Cell metabolism gene	RPL24	SNRPD3	0.852564208	1.29E-35
UCS	Cell metabolism gene	RPL24	POLR2H	0.856329922	3.08E-36
UCS	Cell metabolism gene	RPL24	PSMB1	0.859405473	9.26E-37
UCS	Cell metabolism gene	RPL24	PSMB7	0.869878745	1.23E-38
UCS	Cell metabolism gene	RPL24	DPM2	0.869913925	1.21E-38
UCS	Cell metabolism gene	RPL24	SSR2	0.877924327	3.43E-40
UCS	Cell metabolism gene	RPL24	SLC27A5	0.885768253	8.12E-42
UCS	Cell metabolism gene	RPL24	SNRPD2	0.891430679	4.57E-43
UCS	Cell metabolism gene	RPL24	TIMM8B	0.89491851	7.17E-44
UCS	Cell metabolism gene	RPL24	PFDN5	0.928625317	1.66E-53
UCS	Cell metabolism gene	RPL24	FAU	0.949781323	2.16E-62
UCS	CGC	RPL24	MGMT	0.807031486	3.16E-29
UCS	CGC	RPL24	TFPT	0.826010894	1.16E-31
UCS	CGC	RPL24	RBM10	0.827966782	6.26E-32
UCS	Epifactor	RPL24	NOC2L	0.804396447	6.56E-29
UCS	Epifactor	RPL24	MBD3	0.80922451	1.71E-29
UCS	Epifactor	RPL24	RUVBL2	0.81178212	8.25E-30
UCS	Epifactor	RPL24	PPP4C	0.816489725	2.10E-30
UCS	Epifactor	RPL24	TFPT	0.826010894	1.16E-31
UCS	Epifactor	RPL24	SS18L2	0.828646306	5.04E-32
UCS	Epifactor	RPL24	C17orf49	0.834735891	6.97E-33
UCS	Epifactor	RPL24	PRPF31	0.839575234	1.37E-33
UCS	Epifactor	RPL24	INO80E	0.840903387	8.64E-34
UCS	Epifactor	RPL24	CCDC101	0.845844925	1.52E-34
UCS	Epifactor	RPL24	BRMS1	0.857189432	2.21E-36
UCS	Epifactor	RPL24	DMAP1	0.86104821	4.81E-37
UCS	Epifactor	RPL24	ZNHIT1	0.863880906	1.53E-37
UCS	Epifactor	RPL24	FBL	0.872358298	4.19E-39
UCS	Epifactor	RPL24	SIRT6	0.877016751	5.20E-40
UCS	Epifactor	RPL24	TAF10	0.887984519	2.68E-42
UCS	IUPHAR	RPL24	PHKG2	0.801063636	1.62E-28
UCS	IUPHAR	RPL24	NT5C	0.801418954	1.47E-28
UCS	IUPHAR	RPL24	CSNK2B	0.802518051	1.10E-28
UCS	IUPHAR	RPL24	MVD	0.802969502	9.69E-29
UCS	IUPHAR	RPL24	SMPD2	0.812680948	6.37E-30
UCS	IUPHAR	RPL24	SIRT3	0.823604919	2.45E-31
UCS	IUPHAR	RPL24	MMP24	0.844564641	2.40E-34
UCS	IUPHAR	RPL24	PSMB1	0.859405473	9.26E-37
UCS	IUPHAR	RPL24	SIRT6	0.877016751	5.20E-40
UCS	IUPHAR	RPL24	SLC27A5	0.885768253	8.12E-42
UCS	Kinase	RPL24	PHKG2	0.801063636	1.62E-28
UCS	TF	RPL24	ZNF444	0.801864835	1.31E-28
UCS	TF	RPL24	ZNF580	0.80300613	9.59E-29
UCS	TF	RPL24	AKAP8L	0.807526201	2.75E-29
UCS	TF	RPL24	MBD3	0.80922451	1.71E-29
UCS	TF	RPL24	DRAP1	0.817452869	1.58E-30
UCS	TF	RPL24	THAP7	0.819872649	7.64E-31
UCS	TF	RPL24	THYN1	0.8258022	1.24E-31
UCS	TF	RPL24	ZNF787	0.851099388	2.24E-35
UCS	TF	RPL24	ZNF32	0.861864818	3.47E-37
UCS	TF	RPL24	ZNF428	0.872575663	3.81E-39
UCS	TF	RPL24	THAP3	0.879870487	1.39E-40
UCS	TSG	RPL24	HTRA2	0.807331505	2.91E-29
UCS	TSG	RPL24	SIRT3	0.823604919	2.45E-31
UCS	TSG	RPL24	GABARAP	0.828045823	6.11E-32
UCS	TSG	RPL24	GLTSCR2	0.832782368	1.33E-32
UCS	TSG	RPL24	PARK7	0.838979604	1.67E-33
UCS	TSG	RPL24	NPRL2	0.847873194	7.32E-35
UCS	TSG	RPL24	TSSC4	0.851040722	2.29E-35
UCS	TSG	RPL24	BRMS1	0.857189432	2.21E-36
UCS	TSG	RPL24	GADD45GIP1	0.871212442	6.92E-39
UCS	TSG	RPL24	SIRT6	0.877016751	5.20E-40
UCS	TSG	RPL24	GNB2L1	0.897940794	1.37E-44
UVM	Cell metabolism gene	RPL24	LTA4H	0.851953657	1.27E-23
UVM	IUPHAR	RPL24	SLC25A26	0.806530533	1.74E-19
UVM	IUPHAR	RPL24	LTA4H	0.851953657	1.27E-23
UVM	TSG	RPL24	ST13	0.847783157	3.46E-23

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL24	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL24	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL24	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL24	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL24	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL24	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL24	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL24	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL24	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL24	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL24	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL24	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL24	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL24	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL24	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL24	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL24	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL24	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL24	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL24	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL24	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL24	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL24	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL24	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL24	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL24	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL24	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL24	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL24

POU5F1, AGO4, EBNA-LP, NDRG1, TCF3, ISG15, CUL3, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, CAND1, RPL10A, RPL11, RPL12, RPL13, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL22, RPL23A, RPL23, RPL31, RPL37A, RPL4, RPL5, RPL6, RPL7, RPL9, RPS11, RPS13, RPS15A, RPS16, RPS17, RPS20, RPS23, RPS25, RPS28, RPS2, RPS3A, RPS3, RPS4X, RPS5, RPS6, RPS8, RPSA, RPL27A, RPL7A, RPS19, RPS26, RPS12, RPS24, RPL17, RPS21, EEF1A1, RPS27A, ILF3, NPM1, NCL, RPS27L, RPL10L, RPLP0P6, RPS10P5, CHCHD2, TIMM13, STRAP, PSMB1, ESR1, MAGOH, EIF4A3, SMURF1, TRAF3IP1, FN1, VCAM1, TP63, UBL4A, PAN2, CD81, IGSF8, ICAM1, LSM8, HECW2, HIRIP3, OXR1, PURB, RANBP3, EEF1E1, FAF1, FARSB, GART, HIST1H4A, IARS, NARS, PLOD2, RPLP0, SAMHD1, SRSF6, TROVE2, XRCC5, SF1, SYNCRIP, VPS35, ZBTB1, STAU1, CEP250, CEP76, TP53, TUBG1, TUBGCP3, VCP, EED, RNF2, LUZP4, NAP1L1, RPS6KB2, RPL10, RPL13A, RPL3, RPL34, RPL8, RRP7A, RPL26, RPL27, RPL30, RPL32, RPL35, RPL35A, RPL36, RPL38, RPL3L, RPLP1, RPLP2, RPS10, RPS14, RPS15, RPS18, LOC101929876, RPS27, RPS7, RPS9, UBA52, SFN, XPO1, HIST1H3E, HNRNPU, NOP56, MPHOSPH8, Eif3a, Rpl35, Srp72, Rrbp1, MCM2, RC3H1, CDH1, DEFA5, INO80B, BRCA1, YAP1, CFTR, BDP1, CYB5B, DONSON, GEMIN4, GTF2H4, KDM1A, LEO1, NACA, PSMD1, PSMD6, PTTG1, RPL24, SNAPC1, WDR61, TMPO, MAP2K3, PCBP1, API5, CCNT1, DIMT1, MATN2, TGFB1, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, CHD4, RIOK1, HEXIM1, MEPCE, LARP7, SNAI1, AGR2, RECQL4, REST, MYC, CDK9, Prkaa1, Prkab1, GRWD1, METTL3, METTL14, KIAA1429, EIF4B, RC3H2, PHB, RBX1, USP14, NR2C2, PPP1CC, KRAS, VRK1, SNRNP70, Dppa3, ITFG1, ARAF, HMGB1, RHBDD1, RHBDF2, BIRC3, NFX1, WWP2, SOX2, TRIM28, ARIH2, PLEKHA4, PINK1, TFCP2, WHSC1, FANCD2, HCVgp1, ZC3H18, MAP3K14, ERCC6L2, GTPBP6, HIST1H1C, NEK4, CIT, ANLN, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, INS, NDN, BRD4, Apc2, RBM39, FBP1, RIN3, OGT, AR, PARK2, UFL1, DDRGK1, LRRC59, TRIM37, FZR1, UBC, WDR5, PAGE4, NUDCD2, NAA40, NOTCH2, KCTD12, PRKRA, ZNF346, SPRTN, BTF3, FSCN1, FBXW7, NLRP7, RCHY1, CCNF, PDE4B, N, PSMD9, RB1CC1, KLF4,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL24	LIHC	chr3	101401733	101401733	T	-	Frame_Shift_Del	p.R71fs	3
RPL24	STAD	chr3	101404713	101404713	C	G	Silent	p.R47R	2
RPL24	STAD	chr3	101404703	101404703	A	G	Missense_Mutation	p.W51R	2
RPL24	BLCA	chr3	101404687	101404687	C	G	Missense_Mutation	p.R56T	2
RPL24	UCEC	chr3	101404675	101404675	T	C	Missense_Mutation	p.K60R	2
RPL24	KIRP	chr3	101401697	101401698	-	A	Frame_Shift_Ins	p.T83fs	2
RPL24	UCEC	chr3	101404729	101404729	G	T	Missense_Mutation	p.S42Y	2
RPL24	SKCM	chr3	101399994	101399994	A	T	Silent	p.V153V	2
RPL24	STAD	chr3	101404703	101404703	A	G	Missense_Mutation		2
RPL24	STAD	chr3	101404713	101404713	C	G	Silent		2
RPL24	BLCA	chr3	101399989	101399989	C	T	Missense_Mutation	p.G155E	2
RPL24	BLCA	chr3	101401690	101401690	G	A	Missense_Mutation	p.A85V	1
RPL24	LGG	chr3	101401316	101401316	T	-	Frame_Shift_Del	p.K117fs	1
RPL24	BLCA	chr3	101404752	101404752	C	T	Silent	p.A34A	1
RPL24	STAD	chr3	101399981	101399981	A	G	Missense_Mutation	p.X158Q	1
RPL24	LUAD	chr3	101404672	101404672	T	G	Missense_Mutation	p.K61T	1
RPL24	STAD	chr3	101399981	101399981	A	G	Nonstop_Mutation	p.*158Q	1
RPL24	BLCA	chr3	101400024	101400024	C	A	Silent	p.V143V	1
RPL24	SARC	chr3	101401636	101401636	G	T	Missense_Mutation		1
RPL24	BLCA	chr3	101399989	101399989	C	T	Missense_Mutation		1
RPL24	THYM	chr3	101404746	101404746	G	A	Silent		1
RPL24	CESC	chr3	101405524	101405524	G	A	Missense_Mutation		1
RPL24	SARC	chr3	101401725	101401725	G	T	Silent		1
RPL24	BLCA	chr3	101401690	101401690	G	A	Missense_Mutation		1
RPL24	THYM	chr3	101404746	101404746	G	A	Silent	p.C36C	1
RPL24	COAD	chr3	101399983	101399983	C	T	Missense_Mutation	p.R157H	1
RPL24	SARC	chr3	101405528	101405528	G	T	Missense_Mutation		1
RPL24	BLCA	chr3	101404752	101404752	C	T	Silent		1
RPL24	SARC	chr3	101401308	101401308	G	T	Missense_Mutation		1
RPL24	BLCA	chr3	101404687	101404687	C	G	Missense_Mutation		1
RPL24	KIRP	chr3	101401697	101401698	-	A	Frame_Shift_Ins	p.W83fs	1
RPL24	BLCA	chr3	101401679	101401679	C	T	Missense_Mutation		1
RPL24	KIRP	chr3	101404668	101404668	T	C	Silent	p.G62G	1
RPL24	BLCA	chr3	101400024	101400024	C	A	Nonstop_Mutation	p.*122L	1
RPL24	KIRP	chr3	101401697	101401698	-	A	Frame_Shift_Ins	p.I82fs	1
RPL24	KIRP	chr3	101404668	101404668	T	C	Silent		1

Copy number variation (CNV) of RPL24
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL24
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
83045	N/A	AX396606	COL1A1	chr17	48263334	+	RPL24	chr3	101401670	-
83045	N/A	AA484000	ENOX2	chrX	129893549	-	RPL24	chr3	101399940	+
83045	N/A	D13413	HNRNPU	chr1	245027013	-	RPL24	chr3	101400026	-
83045	STAD	TCGA-BR-8678-01A	RABL3	chr3	120461309	-	RPL24	chr3	101404772	-
100566	N/A	AA483694	RPL24	chr3	101399932	-	APOBEC3A	chr22	39371745	+
80473	N/A	AV681593	RPL24	chr3	101405160	+	CD55	chr1	207554066	-
99029	N/A	BF216084	RPL24	chr3	101399936	-	CFDP1	chr16	75362067	-
101277	ESCA	TCGA-LN-A8I1	RPL24	chr3	101401614	-	CNBD1	chr8	88218220	+
84019	N/A	BG031059	RPL24	chr3	101399935	-	MAMDC2	chr9	72832090	+
84019	N/A	CF124418	RPL24	chr3	101399935	-	MAMDC2	chr9	72832076	+
100576	OV	TCGA-24-1553	RPL24	chr3	101404661	-	MAP2K5	chr15	68061939	+
76276	N/A	BG576073	RPL24	chr3	101399935	-	SLC18A1	chr8	20026099	-
83804	LUSC	TCGA-18-3421	RPL24	chr3	101401272	-	SLC9A9	chr3	143214290	-
83804	LUSC	TCGA-18-3421	RPL24	chr3	101401615	-	SLC9A9	chr3	143214290	-
83804	LUSC	TCGA-18-3421-01A	RPL24	chr3	101401273	-	SLC9A9	chr3	143214290	-
84672	N/A	AA643872	RPL24	chr3	101404774	+	SMC5-AS1	chr9	72832622	-
84672	N/A	AI936209	RPL24	chr3	101404774	+	SMC5-AS1	chr9	72832617	-
100988	N/A	AV699369	RPL24	chr3	101405155	+	TSPAN8	chr12	71792273	+
99791	N/A	BP282298	RPL24	chr3	101401616	-	WDR59	chr16	74927656	-
83045	N/A	AA761029	RPL41	chr12	56511313	-	RPL24	chr3	101404740	-
83045	N/A	AK122630	SLC36A2	chr5	150695752	-	RPL24	chr3	101401710	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
MESO	RPL24	0.0288329670095447	0.81
HNSC	RPL24	0.0390503518469247	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL24	0.0382051278306241	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C3179349	Gastrointestinal Stromal Sarcoma	1	CTD_human