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Translation Factor: RPL26 (NCBI Gene ID:6154) |
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 Gene Summary |
| Gene Information | Gene Name: RPL26 | Gene ID: 6154 | Gene Symbol | RPL26 | Gene ID | 6154 |
| Gene Name | ribosomal protein L26 | |
| Synonyms | DBA11|L26 | |
| Cytomap | 17p13.1 | |
| Type of Gene | protein-coding | |
| Description | 60S ribosomal protein L26large ribosomal subunit protein uL24 | |
| Modification date | 20200313 | |
| UniProtAcc | P61254 | |
| Child GO biological process term(s) under GO:0006412 |
| GO ID | GO term |
| GO:0006417 | Regulation of translation |
| GO:0005840 | Ribosome |
| GO:0045727 | Positive regulation of translation |
| GO:0002181 | Cytoplasmic translation |
| GO:0006412 | Translation |
| Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RPL26 | GO:0071480 | cellular response to gamma radiation | 16213212 |
| Inferred gene age of translation factor. |
| Gene | Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25 |
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| We searched PubMed using 'RPL26[title] AND translation [title] AND human.' |
| Gene | Title | PMID |
| RPL26 | p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability | 27825141 |
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| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. For more annotations, please visit our ExonSkipDB. |
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| Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ENST | Exon skip start (DNA) | Exon Skip end (DNA) | ORF |
| Exon skipping position in the amino acid sequence. |
| ENST | Exon skip start (DNA) | Exon Skip end (DNA) | Len(transcript seq) | Exon skip start (mRNA) | Exon Skip end (mRNA) | Len(amino acid seq) | Exon skip start (AA) | Exon Skip end (AA) |
| Potentially (partially) lost protein functional features of UniProt. |
| UniProtAcc | Exon skip start (AA) | Exon Skip end (AA) | Function feature start (AA) | Function feature end (AA) | Functional feature type | Functional feature desc. |
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| Gene expression level across TCGA pancancer |
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| Gene expression level across GTEx pantissue |
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| Expression level of gene isoforms across TCGA pancancer |
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| Expression level of gene isoforms across GTEx pantissue |
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| Cancer(tissue) type-specific expression level of Translation factor using z-score distriution |
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| Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples) |
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| Cancer type | Translation factor | FC | adj.pval |
| BLCA | RPL26 | -1.81466885367927 | 0.0016937255859375 |
| STAD | RPL26 | 1.63751044801473 | 0.00256496202200651 |
| KIRP | RPL26 | -3.30975212053231 | 0.00275033386424184 |
| PRAD | RPL26 | 1.0903557083151 | 0.0446353080924363 |
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| Translation factor expression regulation through miRNA binding |
| Cancer type | Gene | miRNA | TargetScan binding score (Context++ score percentile) | Coefficient | Pvalue |
| Translation factor expression regulation through methylation in the promoter of Translation factor |
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| Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
| Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation) |
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| Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
| Translation factor expression regulation through copy number variation of Translation factor |
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| Cancer type | Gene | Coefficient | Pvalue |
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| Strongly correlated genes belong to cellular important gene groups with RPL26 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green) |
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| Cancer type | Gene group | Translation factor | Correlated gene | Coefficient | Pvalue |
| DLBC | CGC | RPL26 | NACA | 0.821961362 | 8.00E-13 |
| DLBC | TSG | RPL26 | GNB2L1 | 0.853401621 | 1.31E-14 |
| THYM | Epifactor | RPL26 | FBL | 0.816718622 | 1.96E-30 |
| THYM | Epifactor | RPL26 | C17orf49 | 0.833311726 | 1.12E-32 |
| THYM | TSG | RPL26 | GNB2L1 | 0.816881736 | 1.87E-30 |
| UCS | Epifactor | RPL26 | FBL | 0.816718622 | 1.96E-30 |
| UCS | Epifactor | RPL26 | C17orf49 | 0.833311726 | 1.12E-32 |
| UCS | TSG | RPL26 | GNB2L1 | 0.816881736 | 1.87E-30 |
| UVM | Cell metabolism gene | RPL26 | TOMM20 | 0.807910243 | 1.35E-19 |
| UVM | Cell metabolism gene | RPL26 | TIMM9 | 0.839424345 | 2.36E-22 |
| UVM | TSG | RPL26 | RBMX | 0.81010122 | 9.04E-20 |
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| Protein 3D structure Visit iCn3D. |
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| Protein-protein interaction networks * Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
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| Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
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 * Edge colors based on TCGA cancer types. |
| * Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P)) |
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| Cancer type | Translation factor | Interacting protein coding gene | FC | adj.pval |
| KIRP | RPL26 | RPL18A | -1.51651392808885 | 0.00016188295558095 |
| KICH | RPL26 | RPS27A | 1.75396693785956 | 0.000187873840332031 |
| KIRP | RPL26 | RPS16 | -1.35957043617517 | 0.00019507110118866 |
| COAD | RPL26 | RPS3 | 1.48730375143014 | 0.000411599874496461 |
| KIRP | RPL26 | RPS11 | -1.01861570565103 | 0.00105937570333481 |
| LIHC | RPL26 | RPL8 | -4.84588284974558 | 0.00110314154326131 |
| PRAD | RPL26 | RPL18A | 1.40600175748499 | 0.00205137828390396 |
| KICH | RPL26 | RPL19 | 1.36901182894089 | 0.00250792503356934 |
| KICH | RPL26 | RPS12 | 1.26997381758431 | 0.00308787822723389 |
| LUAD | RPL26 | RPL19 | -1.31398026615725 | 0.00993159558412698 |
| THCA | RPL26 | RPS16 | -6.16322798156577 | 0.0115764821363307 |
| BLCA | RPL26 | RPS12 | -1.47804673440421 | 0.0204124450683594 |
| BLCA | RPL26 | RPS27A | -1.04747470069188 | 0.0258216857910156 |
| HNSC | RPL26 | RPS3 | -4.73505819095135 | 0.0273726439852453 |
| COAD | RPL26 | RPS11 | 1.35307548998204 | 0.0312207043170929 |
| LUSC | RPL26 | RPL19 | -2.14669889516666 | 0.044366810398747 |
| KIRC | RPL26 | RPL19 | -2.73485271276676 | 1.33980982873695e-10 |
| BRCA | RPL26 | RPS12 | -4.91239327478244 | 1.85340619742495e-09 |
| KIRP | RPL26 | RPL37 | -1.17421621947139 | 2.26888805627823e-05 |
| KIRC | RPL26 | RPL35 | -1.06475238059392 | 2.72286325678163e-08 |
| KIRC | RPL26 | RPL8 | -1.18252459971773 | 5.64962994208288e-07 |
| KIRP | RPL26 | RPL8 | -1.53003692350119 | 6.0301274061203e-05 |
| KIRC | RPL26 | RPS16 | -1.66149869889384 | 7.8509870430991e-09 |
| BRCA | RPL26 | RPS27A | -4.28512148200424 | 7.8788217967112e-14 |
| KIRC | RPL26 | RPL37 | -2.87198822058464 | 8.03913394748564e-12 |
| KIRP | RPL26 | RPL35 | -1.52981101975496 | 9.0546440333128e-05 |
| KIRC | RPL26 | RPS3 | -1.29560847926387 | 9.05905681935088e-10 |
| KIRC | RPL26 | RPL18A | -4.43079304960843 | 9.2516163152192e-11 |
| Protein-protein interactors with this translation factor (BIOGRID-3.4.160) |
| PPI interactors with RPL26 |
| PSTPIP1, MAGEB2, DDX56, HNRNPR, MDM2, USP53, NOP56, EBNA-LP, MTOR, RICTOR, TP53, ARRB2, SIRT7, CUL4A, CDK2, CAND1, CBX5, MAGOH, EIF4A3, FN1, VCAM1, UBL4A, ITGA4, PELP1, PAN2, IGSF8, ICAM1, APLP2, TARDBP, RPL17, DARS, EEF1E1, RPL13, RPL15, RPL21, RPL7A, RPL35, RPL36, CEP76, TUBG1, TUBGCP3, RNF2, LUZP4, DHX8, THAP7, RPS8, HNRNPA1, ZNF317, RPS6KB2, RPL14, ATP1B1, ATP1B2, ATP1B3, BRIX1, RPL10, RPL18, RPL19, RPL22, RPL23, RPL24, RPL3, RPL38, RPL4, RPL8, RPS13, RPS18, RPS3, RPL27, RPL30, RPL34, RPL37A, RPL5, RPL6, RPLP0, RPLP2, RPS11, RPS14, RPS15, RPS16, RPS19, RPS25, LOC101929876, RPS26, RPS29, RPS3A, RPS4X, RPS5, RPS6, RPS9, SFN, HIST1H3E, TRIM29, MCM2, Ksr1, CRBN, CDC14B, E4F1, ZC3HAV1, RPL7, SNRNP70, COX15, SDHA, TRIM25, FBXO7, BMP4, WDR77, PCBP1, DIMT1, KRAS, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, CHD4, LARP7, RNF31, TNF, RIOK1, HEXIM1, MEPCE, DPF2, RECQL4, REST, Prkaa1, Prkab1, FBL, GRWD1, ACTC1, PHB, NR2C2, PPP1CC, CTCF, SEC61A1, RPS2, VRK1, HIST1H4A, ITFG1, HMGB1, NFX1, WWP2, Dnajc17, SOX2, TEX101, CMTR1, ARIH2, PLEKHA4, FANCD2, NGB, HCVgp1, ZC3H18, PTPN6, KCNK16, NFATC2IP, E, M, nsp13, nsp14, nsp4, nsp5, nsp6, ORF3a, ORF6, ORF7a, ORF7b, ORF8, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, MAD2L2, KIF20A, KIF23, PRC1, BCAR1, LRRC59, PTEN, N, Apc2, FBP1, MKRN1, DNAJB7, PARK2, UFL1, DDRGK1, TRIM37, ATG3, USP15, UBQLN1, FZR1, NAA40, ZBTB2, YBX3, HIST1H1B, ZCCHC9, MRPS33, MRPL2, CNBP, RPL13A, SF3B2, SRPK3, RBM28, PTCD1, STAU2, MRPL47, RSL1D1, GZF1, ZCCHC3, POP1, RPL32, MRPL9, MRPL1, MOV10, MRPS7, GLYR1, PRR3, FARS2, MRPS2, MRPS5, GNL2, LARP1B, RPL31, ZNF189, RBM4, WHSC1, MRPS11, MRPL50, RBM19, MRPL13, ZC3H8, RPF1, MRPL30, HIST1H1C, MKRN4P, CCDC137, MRPS30, RPS27A, MRPL28, STAU1, MRPL20, TRIM26, MRPL15, SRSF12, SRSF6, DKC1, MRPL45, EBNA1BP2, PRDM15, ZNF512, MRPS35, ZNF574, HIST1H1A, ZCRB1, UPF1, DAP3, ZNF354A, KRI1, MRPS23, RPL26L1, ZNF777, ZNF184, RPL36AL, NOP16, PURB, LARP1, GADD45GIP1, HP1BP3, H2AFY2, MRPS31, ADARB1, ZBTB11, DDX31, MRPL16, DDX27, H2AFX, ZNF275, TOE1, SF3B1, MRPL49, MRPS10, DDX21, IMP4, KRR1, MRPL32, CCDC140, PRKRA, YBX1, MRPL51, MTERF3, NSA2, MRPL24, ICT1, KIAA0020, NGRN, CMSS1, REXO4, TRIM71, NOP2, MRPS18C, SRSF5, ZNF22, MRPL22, RPL11, HIST1H1E, LIN28A, ZNF346, FGFBP1, ZC3H3, MYBBP1A, RPSA, HIST1H2AE, RPSAP58, BTF3, EIF4ENIF1, Cpsf6, NLRP7, RCHY1, CCNF, KLF12, KLF16, KLF4, |
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| Clinically associated variants from ClinVar. |
| Gene | Chr | Position | RefSeq | VarSeq | RefSeeq | VarType | Pathogenic | Disease | VarInfo |
| RPL26 | chr17 | 8280658 | CCTT | C | Microsatellite | Likely_benign | not_provided | ||
| RPL26 | chr17 | 8280936 | T | A | single_nucleotide_variant | Likely_benign | Diamond-Blackfan_anemia | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
| RPL26 | chr17 | 8280943 | C | T | single_nucleotide_variant | Uncertain_significance | Diamond-Blackfan_anemia | SO:0001583|missense_variant | SO:0001583|missense_variant |
| RPL26 | chr17 | 8280961 | T | C | single_nucleotide_variant | Uncertain_significance | Diamond-Blackfan_anemia | SO:0001583|missense_variant | SO:0001583|missense_variant |
| RPL26 | chr17 | 8280978 | G | A | single_nucleotide_variant | Likely_benign | not_provided | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
| RPL26 | chr17 | 8280993 | T | C | single_nucleotide_variant | Benign | Diamond-Blackfan_anemia | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
| RPL26 | chr17 | 8281059 | A | C | single_nucleotide_variant | Benign | not_provided | SO:0001627|intron_variant | SO:0001627|intron_variant |
| RPL26 | chr17 | 8283164 | G | A | single_nucleotide_variant | Uncertain_significance | Diamond-Blackfan_anemia | SO:0001583|missense_variant | SO:0001583|missense_variant |
| RPL26 | chr17 | 8283168 | C | T | single_nucleotide_variant | Likely_benign | Diamond-Blackfan_anemia | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
| RPL26 | chr17 | 8283259 | G | C | single_nucleotide_variant | Uncertain_significance | Diamond-Blackfan_anemia | SO:0001627|intron_variant | SO:0001627|intron_variant |
| RPL26 | chr17 | 8283379 | C | G | single_nucleotide_variant | Benign | not_provided | SO:0001627|intron_variant | SO:0001627|intron_variant |
| RPL26 | chr17 | 8283486 | G | C | single_nucleotide_variant | Benign | not_provided | SO:0001627|intron_variant | SO:0001627|intron_variant |
| RPL26 | chr17 | 8285200 | T | C | single_nucleotide_variant | Likely_benign | not_provided | SO:0001627|intron_variant | SO:0001627|intron_variant |
| RPL26 | chr17 | 8285249 | CA | C | Deletion | Benign | not_provided | SO:0001627|intron_variant | SO:0001627|intron_variant |
| RPL26 | chr17 | 8285249 | CAA | C | Deletion | Benign | not_provided | SO:0001627|intron_variant | SO:0001627|intron_variant |
| RPL26 | chr17 | 8285273 | T | A | single_nucleotide_variant | Likely_benign | not_provided | SO:0001627|intron_variant | SO:0001627|intron_variant |
| RPL26 | chr17 | 8285398 | T | C | single_nucleotide_variant | Benign | not_provided | SO:0001627|intron_variant | SO:0001627|intron_variant |
| RPL26 | chr17 | 8285452 | G | C | single_nucleotide_variant | Likely_benign | not_provided | SO:0001627|intron_variant | SO:0001627|intron_variant |
| RPL26 | chr17 | 8285476 | C | T | single_nucleotide_variant | Uncertain_significance | Diamond-Blackfan_anemia | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
| RPL26 | chr17 | 8285501 | T | C | single_nucleotide_variant | Likely_benign | Diamond-Blackfan_anemia | SO:0001583|missense_variant | SO:0001583|missense_variant |
| RPL26 | chr17 | 8285507 | TTC | T | Deletion | Pathogenic | Diamond-Blackfan_anemia_11 | SO:0001589|frameshift_variant | SO:0001589|frameshift_variant |
| RPL26 | chr17 | 8285533 | G | A | single_nucleotide_variant | Benign | Diamond-Blackfan_anemia | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
| RPL26 | chr17 | 8285605 | A | G | single_nucleotide_variant | Likely_benign | Diamond-Blackfan_anemia | SO:0001819|synonymous_variant | SO:0001819|synonymous_variant |
| RPL26 | chr17 | 8285647 | TAA | T | Deletion | Likely_benign | not_specified | SO:0001627|intron_variant | SO:0001627|intron_variant |
| nsSNVs with sample frequency (size of circle) from TCGA 33 cancers. |
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| SNVs and Indels |
| Gene | Cancer type | Chromosome | Start | End | RefSeeq | MutSeq | Mutation type | AAchange | # samples |
| RPL26 | BRCA | chr17 | 8280943 | 8280943 | C | T | Missense_Mutation | p.R126H | 4 |
| RPL26 | KIRP | chr17 | 8283223 | 8283223 | A | C | Missense_Mutation | p.I67S | 3 |
| RPL26 | BRCA | chr17 | 8285480 | 8285480 | C | T | Missense_Mutation | p.R50Q | 3 |
| RPL26 | ESCA | chr17 | 8280945 | 8280945 | A | C | Silent | p.S125S | 2 |
| RPL26 | STAD | chr17 | 8280949 | 8280949 | T | C | Missense_Mutation | p.K124R | 2 |
| RPL26 | TGCT | chr17 | 8280958 | 8280958 | C | A | Missense_Mutation | p.R121L | 2 |
| RPL26 | ESCA | chr17 | 8280945 | 8280945 | A | C | Silent | 2 | |
| RPL26 | TGCT | chr17 | 8280958 | 8280958 | C | A | Missense_Mutation | 1 | |
| RPL26 | BLCA | chr17 | 8283238 | 8283238 | T | C | Missense_Mutation | 1 | |
| RPL26 | THYM | chr17 | 8285506 | 8285506 | C | T | Silent | 1 | |
| RPL26 | BLCA | chr17 | 8280908 | 8280908 | C | G | Missense_Mutation | 1 | |
| RPL26 | HNSC | chr17 | 8285520 | 8285520 | C | G | Missense_Mutation | 1 | |
| RPL26 | THYM | chr17 | 8280976 | 8280976 | C | T | Missense_Mutation | 1 | |
| RPL26 | BLCA | chr17 | 8285552 | 8285552 | C | T | Missense_Mutation | 1 | |
| RPL26 | HNSC | chr17 | 8285520 | 8285520 | C | G | Missense_Mutation | p.E37Q | 1 |
| RPL26 | THYM | chr17 | 8285506 | 8285506 | C | T | Silent | p.K41K | 1 |
| RPL26 | BLCA | chr17 | 8280908 | 8280908 | C | G | Missense_Mutation | p.E138Q | 1 |
| RPL26 | BLCA | chr17 | 8285553 | 8285553 | G | C | Missense_Mutation | p.R26G | 1 |
| RPL26 | KIRP | chr17 | 8283223 | 8283223 | A | C | Missense_Mutation | 1 | |
| RPL26 | BLCA | chr17 | 8285552 | 8285552 | C | T | Missense_Mutation | p.R26Q | 1 |
| RPL26 | LIHC | chr17 | 8285494 | 8285494 | T | C | Silent | 1 | |
| RPL26 | SARC | chr17 | 8280921 | 8280921 | G | T | Silent | 1 | |
| RPL26 | SARC | chr17 | 8280925 | 8280925 | T | C | Missense_Mutation | p.K132R | 1 |
| RPL26 | COAD | chr17 | 8280962 | 8280962 | C | T | Missense_Mutation | p.E120K | 1 |
| RPL26 | ESCA | chr17 | 8280945 | 8280945 | A | C | Silent | p.S125 | 1 |
| RPL26 | BLCA | chr17 | 8285553 | 8285553 | G | C | Missense_Mutation | 1 |
| Copy number variation (CNV) of RPL26 * Click on the image to open the original image in a new window. |
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| Fusion gene breakpoints (product of the structural variants (SVs)) across RPL26 * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion genes with this translation factor from FusionGDB2.0. |
| FusionGDB2 ID | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 77825 | N/A | BI491313 | ANAPC5 | chr12 | 121833298 | - | RPL26 | chr17 | 8280839 | + |
| 77825 | N/A | BG230395 | DOCK10 | chr2 | 225784973 | + | RPL26 | chr17 | 8280841 | + |
| 77825 | N/A | EC512967 | FAM186A | chr12 | 50759867 | - | RPL26 | chr17 | 8280841 | + |
| 77825 | N/A | BF812918 | HOXB9 | chr17 | 46700001 | + | RPL26 | chr17 | 8286512 | - |
| 77825 | PRAD | TCGA-CH-5761-01A | MAPT | chr17 | 44039836 | + | RPL26 | chr17 | 8285633 | - |
| 77825 | COAD | TCGA-AA-3850 | MIER2 | chr19 | 325634 | - | RPL26 | chr17 | 8285633 | - |
| 77825 | OV | TCGA-29-1697-01A | MIER2 | chr19 | 325635 | - | RPL26 | chr17 | 8285633 | - |
| 77825 | N/A | EC581159 | NUP50 | chr22 | 45583427 | + | RPL26 | chr17 | 8280848 | + |
| 77825 | N/A | AA226614 | OTOGL | chr12 | 80496635 | + | RPL26 | chr17 | 8280841 | + |
| 77825 | N/A | AA230225 | OTOGL | chr12 | 80496635 | + | RPL26 | chr17 | 8280839 | + |
| 100818 | N/A | BP281133 | RPL26 | chr17 | 8280925 | - | ATXN7 | chr3 | 63927528 | - |
| 101912 | LUAD | TCGA-55-8207-01A | RPL26 | chr17 | 8285461 | - | CYSTM1 | chr5 | 139574031 | + |
| 100891 | N/A | BP228087 | RPL26 | chr17 | 8280839 | - | KIAA1549L | chr11 | 33419485 | - |
| 76316 | N/A | EC486795 | RPL26 | chr17 | 8280949 | + | LINC01006 | chr7 | 156426002 | - |
| 101074 | N/A | AW020253 | RPL26 | chr17 | 8280839 | - | MACROD2 | chr20 | 14932749 | - |
| 82394 | N/A | BP226166 | RPL26 | chr17 | 8280841 | - | METTL15 | chr11 | 28301458 | + |
| 86345 | N/A | AA483495 | RPL26 | chr17 | 8280841 | - | OTOGL | chr12 | 80496632 | - |
| 86345 | N/A | BG032781 | RPL26 | chr17 | 8280839 | - | OTOGL | chr12 | 80496635 | - |
| 86345 | N/A | BM013521 | RPL26 | chr17 | 8280841 | - | OTOGL | chr12 | 80496635 | - |
| 103050 | N/A | DN916015 | RPL26 | chr17 | 8280840 | - | PCDH15 | chr10 | 56104655 | + |
| 90605 | N/A | BP283575 | RPL26 | chr17 | 8280839 | - | PCDH9 | chr13 | 67060769 | + |
| 77825 | N/A | AA558624 | RPL26 | chr17 | 8280859 | - | RPL26 | chr17 | 8280833 | + |
| 77825 | N/A | EC455705 | RPL26 | chr17 | 8285498 | + | RPL26 | chr17 | 8280977 | - |
| 96487 | N/A | EC556734 | RPL26 | chr17 | 8280901 | + | RPS29 | chr14 | 50050346 | - |
| 99241 | N/A | BI855828 | RPL26 | chr17 | 8107437 | - | WHSC1 | chr4 | 1959196 | - |
| 100954 | N/A | BI493240 | RPL26 | chr17 | 8280843 | - | ZFAND6 | chr15 | 80358653 | + |
| 77838 | N/A | EC499282 | RPS29 | chr14 | 50050356 | + | RPL26 | chr17 | 8280903 | - |
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| Kaplan-Meier plots with logrank tests of overall survival (OS) |
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| Cancer type | Translation factor | Coefficent | Hazard ratio | Wald test pval | Likelihool ratio pval | Logrank test pval | # samples |
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| Differential gene expression between female and male. (Wilcoxon test, pval<0.05) |
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| Cancer type | Translation factor | pval | adj.p |
| KIRC | RPL26 | 0.00437566341107188 | 0.12 |
| BRCA | RPL26 | 0.022497348660935 | 0.61 |
| THYM | RPL26 | 0.0281422830641589 | 0.73 |
| SARC | RPL26 | 0.03223018236199 | 0.81 |
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| Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05) |
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| Cancer type | Translation factor | pval | adj.p |
| LGG | RPL26 | 0.0304494692232635 | 1 |
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| Drugs targeting genes involved in this translation factor. (DrugBank Version 5.1.8 2021-05-08) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| Diseases associated with this translation factor. (DisGeNet 4.0) |
| Disease ID | Disease Name | # PubMeds | Disease source |
| C1260899 | Anemia, Diamond-Blackfan | 2 | GENOMICS_ENGLAND;ORPHANET |
| C2931850 | Aase Smith syndrome 2 | 1 | ORPHANET |
| C3554042 | DIAMOND-BLACKFAN ANEMIA 11 | 1 | CTD_human;GENOMICS_ENGLAND |
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