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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL27 (NCBI Gene ID:6155)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL27
	Gene ID: 6155
	Gene Symbol	RPL27
	Gene ID	6155
	Gene Name	ribosomal protein L27
	Synonyms	DBA16\|L27
	Cytomap	17q21.31
	Type of Gene	protein-coding
	Description	60S ribosomal protein L27large ribosomal subunit protein eL27
	Modification date	20200313
	UniProtAcc	P61353

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL27	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL27[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL27	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000253788	41150765	41150848	5CDS-5UTR
ENST00000253788	41151949	41152119	Frame-shift
ENST00000589037	41151949	41152119	Frame-shift
ENST00000589913	41151949	41152119	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
HNSC	RPL27	-1.15368387664859	0.00329169979568178
THCA	RPL27	-1.83254033854825	0.00492925389458784
LUAD	RPL27	-3.66906241466368	0.00773628245812536
STAD	RPL27	-1.4564848176927	0.0279771662317216
KIRP	RPL27	-1.94671018280482	2.0815059542656e-07
KIRC	RPL27	-1.37952962808509	7.04452987764158e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
ESCA	RPL27	-0.066515617	0.026422152
UCEC	RPL27	0.103620497	0.041767984
KIRC	RPL27	-0.042090627	0.043105656

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL27 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	RPL27	PFDN5	0.816628485	1.48E-12
DLBC	Cell metabolism gene	RPL27	TIMM9	0.817659725	1.32E-12
DLBC	Cell metabolism gene	RPL27	POLR2F	0.82745134	4.15E-13
DLBC	Cell metabolism gene	RPL27	FAU	0.850959073	1.87E-14
DLBC	Cell metabolism gene	RPL27	NME2	0.852058026	1.59E-14
DLBC	Cell metabolism gene	RPL27	TOMM22	0.852763807	1.44E-14
DLBC	Cell metabolism gene	RPL27	SNRPD2	0.880166405	1.72E-16
DLBC	CGC	RPL27	NACA	0.863190338	2.99E-15
DLBC	Epifactor	RPL27	FBL	0.843636109	5.18E-14
DLBC	TF	RPL27	THAP4	0.806467233	4.56E-12
DLBC	TF	RPL27	NME2	0.852058026	1.59E-14
DLBC	TSG	RPL27	HINT1	0.810399156	2.98E-12
DLBC	TSG	RPL27	PARK7	0.824099743	6.21E-13
DLBC	TSG	RPL27	GNB2L1	0.870082626	9.84E-16
GBM	Cell metabolism gene	RPL27	DGUOK	0.800583505	1.18E-39
GBM	Cell metabolism gene	RPL27	PSMA6	0.801152081	9.48E-40
GBM	Cell metabolism gene	RPL27	SUCLG1	0.801626812	7.91E-40
GBM	Cell metabolism gene	RPL27	MLX	0.804158294	2.98E-40
GBM	Cell metabolism gene	RPL27	NME1	0.809219196	4.06E-41
GBM	Cell metabolism gene	RPL27	NME2	0.814674669	4.43E-42
GBM	Cell metabolism gene	RPL27	LSM1	0.81749907	1.37E-42
GBM	Cell metabolism gene	RPL27	PSMA7	0.820440336	3.92E-43
GBM	Cell metabolism gene	RPL27	SSR4	0.821668321	2.31E-43
GBM	Cell metabolism gene	RPL27	PSMA5	0.824156705	7.85E-44
GBM	Cell metabolism gene	RPL27	PSMB4	0.824272089	7.46E-44
GBM	Cell metabolism gene	RPL27	LSM2	0.825871534	3.69E-44
GBM	Cell metabolism gene	RPL27	CCT4	0.828355786	1.22E-44
GBM	Cell metabolism gene	RPL27	ZNRD1	0.831698603	2.66E-45
GBM	Cell metabolism gene	RPL27	TIMM8B	0.846625668	1.94E-48
GBM	Cell metabolism gene	RPL27	SNRPD2	0.849022518	5.67E-49
GBM	Cell metabolism gene	RPL27	SSR2	0.850555761	2.55E-49
GBM	Cell metabolism gene	RPL27	PSMB3	0.854076626	3.94E-50
GBM	Cell metabolism gene	RPL27	SNRPG	0.867749367	1.69E-53
GBM	Cell metabolism gene	RPL27	PFDN5	0.883375495	7.69E-58
GBM	Cell metabolism gene	RPL27	FAU	0.892368475	1.25E-60
GBM	Epifactor	RPL27	DPY30	0.814810147	4.19E-42
GBM	TF	RPL27	MLX	0.804158294	2.98E-40
GBM	TF	RPL27	NME2	0.814674669	4.43E-42
GBM	TSG	RPL27	NME1	0.809219196	4.06E-41
GBM	TSG	RPL27	GAS5	0.82529262	4.76E-44
HNSC	Cell metabolism gene	RPL27	NME2	0.827057675	3.24E-143
HNSC	TF	RPL27	NME2	0.827057675	3.24E-143
THYM	Cell metabolism gene	RPL27	EXOSC4	0.800589637	1.84E-28
THYM	Cell metabolism gene	RPL27	TIMM50	0.800845159	1.72E-28
THYM	Cell metabolism gene	RPL27	PSMC3	0.802428677	1.12E-28
THYM	Cell metabolism gene	RPL27	FAU	0.805437771	4.92E-29
THYM	Cell metabolism gene	RPL27	PSMB3	0.806750364	3.42E-29
THYM	Cell metabolism gene	RPL27	TIMM8B	0.809645473	1.52E-29
THYM	Cell metabolism gene	RPL27	PFDN5	0.810236463	1.28E-29
THYM	Cell metabolism gene	RPL27	PSMB7	0.811170123	9.82E-30
THYM	Cell metabolism gene	RPL27	SLC27A5	0.815164382	3.09E-30
THYM	Cell metabolism gene	RPL27	PSMC5	0.823131205	2.83E-31
THYM	Cell metabolism gene	RPL27	SSR2	0.823706257	2.37E-31
THYM	Cell metabolism gene	RPL27	SNRPD2	0.837807584	2.49E-33
THYM	Cell metabolism gene	RPL27	TIMM13	0.838307528	2.10E-33
THYM	Cell metabolism gene	RPL27	TALDO1	0.841360674	7.38E-34
THYM	Epifactor	RPL27	EXOSC4	0.800589637	1.84E-28
THYM	Epifactor	RPL27	PRPF31	0.801862851	1.31E-28
THYM	Epifactor	RPL27	BRMS1	0.825228244	1.48E-31
THYM	Epifactor	RPL27	FBL	0.869924707	1.21E-38
THYM	IUPHAR	RPL27	SLC27A5	0.815164382	3.09E-30
THYM	TF	RPL27	REXO4	0.830437843	2.84E-32
THYM	TF	RPL27	ZNF581	0.837500583	2.77E-33
THYM	TSG	RPL27	PHB	0.812943802	5.90E-30
THYM	TSG	RPL27	BRMS1	0.825228244	1.48E-31
THYM	TSG	RPL27	TSSC4	0.828928718	4.61E-32
UCS	Cell metabolism gene	RPL27	EXOSC4	0.800589637	1.84E-28
UCS	Cell metabolism gene	RPL27	TIMM50	0.800845159	1.72E-28
UCS	Cell metabolism gene	RPL27	PSMC3	0.802428677	1.12E-28
UCS	Cell metabolism gene	RPL27	FAU	0.805437771	4.92E-29
UCS	Cell metabolism gene	RPL27	PSMB3	0.806750364	3.42E-29
UCS	Cell metabolism gene	RPL27	TIMM8B	0.809645473	1.52E-29
UCS	Cell metabolism gene	RPL27	PFDN5	0.810236463	1.28E-29
UCS	Cell metabolism gene	RPL27	PSMB7	0.811170123	9.82E-30
UCS	Cell metabolism gene	RPL27	SLC27A5	0.815164382	3.09E-30
UCS	Cell metabolism gene	RPL27	PSMC5	0.823131205	2.83E-31
UCS	Cell metabolism gene	RPL27	SSR2	0.823706257	2.37E-31
UCS	Cell metabolism gene	RPL27	SNRPD2	0.837807584	2.49E-33
UCS	Cell metabolism gene	RPL27	TIMM13	0.838307528	2.10E-33
UCS	Cell metabolism gene	RPL27	TALDO1	0.841360674	7.38E-34
UCS	Epifactor	RPL27	EXOSC4	0.800589637	1.84E-28
UCS	Epifactor	RPL27	PRPF31	0.801862851	1.31E-28
UCS	Epifactor	RPL27	BRMS1	0.825228244	1.48E-31
UCS	Epifactor	RPL27	FBL	0.869924707	1.21E-38
UCS	IUPHAR	RPL27	SLC27A5	0.815164382	3.09E-30
UCS	TF	RPL27	REXO4	0.830437843	2.84E-32
UCS	TF	RPL27	ZNF581	0.837500583	2.77E-33
UCS	TSG	RPL27	PHB	0.812943802	5.90E-30
UCS	TSG	RPL27	BRMS1	0.825228244	1.48E-31
UCS	TSG	RPL27	TSSC4	0.828928718	4.61E-32

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL27	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL27	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL27	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL27	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL27	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL27	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL27	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL27	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL27	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL27	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL27	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL27	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL27	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL27	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL27	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL27	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL27	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL27	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL27	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL27	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL27	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL27	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL27	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL27	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL27	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL27	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL27	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL27	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL27

AGO4, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, RPL12, RPL14, RPL23, RPL31, RPL9, RPS10, RPS13, RPS15A, RPS16, RPS17, RPS23, RPSA, RPS4X, RPS26, RPS24, RPL6, RPS2, RPS9, RPL30, RPL4, RPL18, RPL19, RPS8, RPS3A, RPS21, RPS29, RPL37, ILF3, RPL10L, RPLP0P6, SLC25A3, EVPL, NDUFS1, FUT8, PA2G4, UBL4A, PAN2, CD81, IGSF8, ICAM1, NRP1, EP300, CHUK, HNRNPM, MRE11A, QARS, RPL26L1, RTCB, DDX1, DHX9, FLII, rev, ZBTB1, AURKA, CEP250, TP53, TUBGCP4, HUWE1, RNF2, EBNA1BP2, DDX56, NOC2L, RPL10, RPL10A, RPL11, RPL13A, RPL15, RPL23A, BRIX1, DDX18, GTPBP4, MRTO4, NSA2, PABPC1, PABPC4, PES1, RPL13, RPL18A, RPL21, RPL22, RPL24, RPL26, RPL34, RPL36, RPL38, RPL5, RPLP0, RPS12, RPS15, RPS19, RPS20, RPS25, RPS27, RPS3, RPS5, RPL27A, RPL3, RPL32, RPL35, RPL35A, RPL37A, RPL3L, RPL7, RPL7A, RPL8, RPLP1, RPLP2, RPS11, RPS14, RPS18, LOC101929876, RPS6, RPS7, PTEN, HIST1H3E, HNRNPU, NPM1, GAR1, C17orf85, NEDD1, Eif3a, Eif3e, Pard6b, Rpl35, Rrbp1, MCM2, Ksr1, CRBN, CNBP, KIAA0020, RPL28, RRS1, MECP2, SART3, KNOP1, NCL, CYLD, INO80B, COQ2, COX15, DLD, DNM1L, SOAT1, VDAC1, TRIM25, BRCA1, MTF1, LEO1, MRPL22, PELO, PSMD1, RPL27, TCOF1, HIF1AN, TMPO, PPP1CC, BMP4, PPP6C, API5, ARNT, CSNK1A1, HDAC4, MATN2, PCBP1, PPIE, UBE2L6, YAP1, PRPF8, EFTUD2, AAR2, PIH1D1, RNF4, CHD3, CHD4, LARP7, RNF31, TNF, SPDL1, FGF11, HEXIM1, MEPCE, SNAI1, AGR2, RECQL4, REST, MYC, Prkaa1, RPS6KB2, METTL14, RC3H1, RC3H2, ATG16L1, ZBTB7A, PHB, NR2C2, CTCF, VRK1, HIST1H4A, SNRNP70, Dppa3, ITFG1, HMGB1, BIRC3, STAU1, NFX1, WWP2, MATR3, SOX2, CMTR1, SPANXN2, ARIH2, PLEKHA4, PINK1, TFCP2, FANCD2, ORF50, ZC3H18, GRB7, MAP3K14, PTPN6, RAB5A, EMC4, SEPT11, TRPM7, ERAP2, SNIP1, E, M, nsp13, nsp4, nsp5, nsp6, ORF3a, ORF7a, ORF7b, NEK4, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF23, PRC1, LRRC59, INS, NDN, Rnf183, BRD4, CIC, Apc2, RBM39, FBP1, BKRF1, CUL4A, RIN3, DNAJC15, DNAJC16, DNAJC19, DNAJC1, DNAJC25, DNAJC2, SETD8, SMYD3, REPIN1, PARK2, UFL1, DDRGK1, TRIM37, FZR1, PAGE4, MYBBP1A, ADARB1, H1FOO, ZNF48, NPM3, ABT1, PRKRA, MAGEB2, LIN28A, IL17B, RPL36AL, ZNF346, SPRTN, BTF3, FBXW7, RCHY1, OPTN, N, PSMD9, RB1CC1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPL27	chr17	41150464	TG	T	Deletion	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
RPL27	chr17	41150471	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
RPL27	chr17	41150521	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
RPL27	chr17	41150765	G	A	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_16	SO:0001574\|splice_acceptor_variant,SO:0001623\|5_prime_UTR_variant	SO:0001574\|splice_acceptor_variant,SO:0001623\|5_prime_UTR_variant
RPL27	chr17	41150842	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
RPL27	chr17	41150949	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL27	chr17	41150983	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL27	chr17	41151743	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL27	chr17	41151958	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL27	chr17	41152048	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL27	chr17	41154464	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL27	chr17	41154490	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL27	chr17	41154600	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL27	chr17	41154817	A	C	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_16\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL27	chr17	41155244	C	T	single_nucleotide_variant	Benign	not_provided

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL27	SKCM	chr17	41152038	41152038	T	A	Missense_Mutation	p.M57K	2
RPL27	STAD	chr17	41151963	41151963	G	A	Missense_Mutation	p.G32D	2
RPL27	KIRC	chr17	41154776	41154776	A	G	Missense_Mutation	p.E113G	2
RPL27	UCEC	chr17	41151975	41151975	G	A	Missense_Mutation	p.R36H	2
RPL27	LIHC	chr17	41150829	41150829	G	A	Missense_Mutation	p.R21H	2
RPL27	SKCM	chr17	41152077	41152077	C	T	Missense_Mutation	p.S70F	2
RPL27	CESC	chr17	41154798	41154798	G	C	Missense_Mutation	p.E120D	2
RPL27	COAD	chr17	41152038	41152038	T	C	Missense_Mutation	p.M57T	1
RPL27	SKCM	chr17	41152101	41152101	A	G	Missense_Mutation	p.N78S	1
RPL27	HNSC	chr17	41154796	41154796	G	C	Missense_Mutation		1
RPL27	SKCM	chr17	41151974	41151974	C	T	Missense_Mutation	p.R36C	1
RPL27	HNSC	chr17	41154796	41154796	G	C	Missense_Mutation	p.E120Q	1
RPL27	STAD	chr17	41150739	41150739	G	A	Missense_Mutation		1
RPL27	KIRC	chr17	41154694	41154694	T	A	Missense_Mutation	p.S86T	1
RPL27	UCEC	chr17	41154751	41154751	G	T	Missense_Mutation	p.A105S	1
RPL27	KIRP	chr17	41152114	41152114	C	A	Silent		1
RPL27	LIHC	chr17	41150829	41150829	G	A	Missense_Mutation		1
RPL27	LIHC	chr17	41154757	41154757	A	-	Frame_Shift_Del	p.K107fs	1
RPL27	CESC	chr17	41154798	41154798	G	C	Missense_Mutation		1

Copy number variation (CNV) of RPL27
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL27
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101599	N/A	EC579219	AFF2	chrX	147592104	+	RPL27	chr17	41150774	+
101599	N/A	AA885969	APPL2	chr12	105611891	-	RPL27	chr17	41154976	-
101599	Non-Cancer	ERR315386	ATP6V0A1	chr17	40613029	+	RPL27	chr17	41154690	+
101599	ESCA	TCGA-ZR-A9CJ	CTCF	chr16	67605167	+	RPL27	chr17	41150765	+
101599	THCA	TCGA-H2-A2K9-01A	GPR107	chr9	132890993	+	RPL27	chr17	41152084	+
101599	Non-Cancer	ERR188094	IFI35	chr17	41158985	+	RPL27	chr17	41151950	+
101599	N/A	AA503644	OXA1L	chr14	23240714	-	RPL27	chr17	41150760	+
101599	BRCA	TCGA-GM-A2DB	PHKG2	chr16	30759811	+	RPL27	chr17	41150765	+
101599	BRCA	TCGA-GM-A2DB-01A	PHKG2	chr16	30759811	+	RPL27	chr17	41150766	+
99026	KIRC	TCGA-BP-4343-01A	RPL27	chr17	41150848	+	AARSD1	chr17	41103911	-
102221	N/A	EC557256	RPL27	chr17	41154968	+	BCL2L13	chr22	18168862	-
76359	N/A	BU674462	RPL27	chr17	41150769	-	C1orf210	chr1	43748098	-
76359	N/A	EC578828	RPL27	chr17	41150848	+	CASP12	chr11	104761981	+
101927	COAD	TCGA-AA-A00Q-01A	RPL27	chr17	41154760	+	CCDC57	chr17	80086381	-
99029	N/A	CF122662	RPL27	chr17	41154976	+	CFDP1	chr16	75362062	-
86496	N/A	BG575943	RPL27	chr17	41154976	+	DYNC1I1	chr7	95442425	-
98964	N/A	AA876337	RPL27	chr17	41154976	+	FAM65B	chr6	24811921	-
94447	N/A	DB013482	RPL27	chr17	41154938	+	KRT13	chr17	39661864	-
101523	N/A	EC563952	RPL27	chr17	41154762	-	MKLN1	chr7	130927758	-
99418	LGG	TCGA-TM-A84F-01A	RPL27	chr17	41152119	+	NBR1	chr17	41361920	+
99418	THYM	TCGA-ZB-A962-01A	RPL27	chr17	41150848	+	NBR1	chr17	41348498	+
95509	N/A	EC440105	RPL27	chr17	41150848	+	NME1-NME2	chr17	49245608	+
95509	N/A	FJ655906	RPL27	chr17	41154765	+	NME1-NME2	chr17	49248882	+
76359	N/A	CV327306	RPL27	chr17	41150760	-	RASIP1	chr19	49228152	+
101599	N/A	AA648115	RPL27	chr17	41154912	+	RPL27	chr17	41152105	-
101599	N/A	BC021886	RPL27	chr17	41154906	-	RPL27	chr17	41150801	+
101599	N/A	BU685466	RPL27	chr17	41154913	-	RPL27	chr17	41151948	+
97303	STAD	TCGA-BR-A4QI-01A	RPL27	chr17	41152119	+	TKT	chr3	53276258	-
92537	N/A	BF246496	RPL27	chr17	41154954	+	TMTC3	chr12	88560791	-
100409	BRCA	TCGA-EW-A1OY	RPL27	chr17	41152119	+	VAT1	chr17	41168565	-
101599	N/A	T59674	RPS6	chr9	19376507	+	RPL27	chr17	41150472	+
101599	N/A	L25346	ZNF19	chr16	71511841	-	RPL27	chr17	41152033	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
BRCA	RPL27	0.691078523164058	-0.369501824674919	0.000451487588618526	0.000371626380645072	0.000454863306861251	1200
LGG	RPL27	0.617867747166826	-0.481480845774179	0.00231889589604139	0.00207087200052968	0.00271902649281731	525
ACC	RPL27	1.78747684565858	0.580805042024411	0.00848914570598305	0.0100490457223866	0.00823574779181042	79
KIRC	RPL27	1.41501889656441	0.347142885468513	2.54816813600951e-05	6.93459567289708e-05	3.04792996484526e-05	604
KIRC	RPL27	1.41501889656441	0.347142885468513	2.54816813600951e-05	6.93459567289708e-05	3.04792996484526e-05	604

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPL27	0.013902895938085	0.39
MESO	RPL27	0.0410195741336613	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL27	7.94515061975771e-05	0.0026
LAML	RPL27	0.0122954622107589	0.39
PAAD	RPL27	0.0156406017145347	0.48

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1260899	Anemia, Diamond-Blackfan	2	GENOMICS_ENGLAND;ORPHANET
C2931850	Aase Smith syndrome 2	1	ORPHANET
C4479424	DIAMOND-BLACKFAN ANEMIA 16	1	CTD_human;GENOMICS_ENGLAND