Home

Download

Statistics

Examples

Help

Contact

	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL30 (NCBI Gene ID:6156)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL30
	Gene ID: 6156
	Gene Symbol	RPL30
	Gene ID	6156
	Gene Name	ribosomal protein L30
	Synonyms	L30
	Cytomap	8q22.2
	Type of Gene	protein-coding
	Description	60S ribosomal protein L30large ribosomal subunit protein eL30
	Modification date	20200313
	UniProtAcc	P62888

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPL30	GO:0002181	cytoplasmic translation	25957688
Hgene	RPL30	GO:0031640	killing of cells of other organism	15019208
Hgene	RPL30	GO:0050829	defense response to Gram-negative bacterium	15019208
Hgene	RPL30	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	15019208

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL30	>1119.25

Top

Translation Studies in PubMed

We searched PubMed using 'RPL30[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL30	.	.

Top

Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000287038	99054872	99055003	Frame-shift
ENST00000521291	99054872	99055003	Frame-shift
ENST00000287038	99057170	99057316	Frame-shift
ENST00000521291	99057170	99057316	Frame-shift
ENST00000287038	99057574	99057627	3UTR-3CDS

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

Top

Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	RPL30	-1.98579595284099	1.50488235365288e-05
LUSC	RPL30	-2.27386662283158	9.09971457907932e-05
KIRC	RPL30	-1.65763742142219	9.40007073737459e-12

Top

Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
OV	RPL30	-0.138121703	0.013003164
KICH	RPL30	0.056029916	0.014374401
SARC	RPL30	-0.208974086	0.048607179

Top

Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL30 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	RPL30	POLR2J	0.806098596	4.75E-12
DLBC	Cell metabolism gene	RPL30	PFDN5	0.843197062	5.49E-14
DLBC	Cell metabolism gene	RPL30	FAU	0.87299933	6.03E-16
DLBC	CGC	RPL30	NACA	0.828806957	3.51E-13
DLBC	TF	RPL30	ZNF581	0.865520215	2.07E-15
DLBC	TSG	RPL30	GLTSCR2	0.81486232	1.81E-12
DLBC	TSG	RPL30	GNB2L1	0.88359545	9.15E-17
GBM	Cell metabolism gene	RPL30	SSR2	0.839922684	5.45E-47
GBM	TSG	RPL30	GAS5	0.803369427	4.05E-40
KIRP	Cell metabolism gene	RPL30	SNRPD2	0.811570951	6.57E-77
LGG	Cell metabolism gene	RPL30	FAU	0.860466359	9.57E-157
LGG	CGC	RPL30	NACA	0.829437294	1.23E-135
LGG	TSG	RPL30	GNB2L1	0.81304502	3.88E-126
LGG	TSG	RPL30	GAS5	0.816607891	4.03E-128
LIHC	Epifactor	RPL30	ENY2	0.819492004	7.72E-104
PRAD	CGC	RPL30	COX6C	0.80052781	5.97E-124
THCA	Cell metabolism gene	RPL30	PFDN5	0.816596512	3.73E-138
THCA	Cell metabolism gene	RPL30	SNRPD2	0.821813688	2.25E-141
THCA	Cell metabolism gene	RPL30	FAU	0.832533815	2.47E-148
THCA	Epifactor	RPL30	FBL	0.804553383	4.23E-131
THCA	TSG	RPL30	GNB2L1	0.805446098	1.32E-131
THYM	Cell metabolism gene	RPL30	PSMD13	0.801677609	1.38E-28
THYM	Cell metabolism gene	RPL30	PSME1	0.803252873	8.97E-29
THYM	Cell metabolism gene	RPL30	ACOT8	0.803873609	7.57E-29
THYM	Cell metabolism gene	RPL30	GFER	0.803902114	7.51E-29
THYM	Cell metabolism gene	RPL30	EXOSC5	0.805862809	4.37E-29
THYM	Cell metabolism gene	RPL30	TALDO1	0.806210614	3.97E-29
THYM	Cell metabolism gene	RPL30	IMPDH2	0.807875828	2.50E-29
THYM	Cell metabolism gene	RPL30	POLR2H	0.809647644	1.52E-29
THYM	Cell metabolism gene	RPL30	GUK1	0.810985686	1.04E-29
THYM	Cell metabolism gene	RPL30	ITPA	0.813940523	4.42E-30
THYM	Cell metabolism gene	RPL30	TIMM50	0.816409122	2.15E-30
THYM	Cell metabolism gene	RPL30	TOMM22	0.818377963	1.20E-30
THYM	Cell metabolism gene	RPL30	PSMC3	0.81879787	1.06E-30
THYM	Cell metabolism gene	RPL30	PSMB3	0.822976813	2.97E-31
THYM	Cell metabolism gene	RPL30	POLR2I	0.824737079	1.73E-31
THYM	Cell metabolism gene	RPL30	LSM2	0.825962851	1.18E-31
THYM	Cell metabolism gene	RPL30	EXOSC4	0.826124151	1.12E-31
THYM	Cell metabolism gene	RPL30	PSMB7	0.826487015	9.99E-32
THYM	Cell metabolism gene	RPL30	DPM2	0.827310092	7.71E-32
THYM	Cell metabolism gene	RPL30	POLR2F	0.828947938	4.58E-32
THYM	Cell metabolism gene	RPL30	SNRPD3	0.83071506	2.60E-32
THYM	Cell metabolism gene	RPL30	APRT	0.834351363	7.92E-33
THYM	Cell metabolism gene	RPL30	TIMM13	0.850567927	2.72E-35
THYM	Cell metabolism gene	RPL30	TIMM8B	0.857564282	1.91E-36
THYM	Cell metabolism gene	RPL30	SLC27A5	0.858928167	1.12E-36
THYM	Cell metabolism gene	RPL30	PGLS	0.859349339	9.47E-37
THYM	Cell metabolism gene	RPL30	SSR2	0.877518046	4.14E-40
THYM	Cell metabolism gene	RPL30	SNRPD2	0.880390877	1.09E-40
THYM	Cell metabolism gene	RPL30	PFDN5	0.894165454	1.08E-43
THYM	Cell metabolism gene	RPL30	FAU	0.922297032	2.25E-51
THYM	CGC	RPL30	SDHAF2	0.801327144	1.51E-28
THYM	CGC	RPL30	TFPT	0.816767832	1.93E-30
THYM	Epifactor	RPL30	EXOSC5	0.805862809	4.37E-29
THYM	Epifactor	RPL30	CCDC101	0.81073698	1.11E-29
THYM	Epifactor	RPL30	NOC2L	0.811859518	8.06E-30
THYM	Epifactor	RPL30	TFPT	0.816767832	1.93E-30
THYM	Epifactor	RPL30	ZNHIT1	0.818347511	1.21E-30
THYM	Epifactor	RPL30	EXOSC4	0.826124151	1.12E-31
THYM	Epifactor	RPL30	PRPF31	0.827219842	7.93E-32
THYM	Epifactor	RPL30	C17orf49	0.841273494	7.61E-34
THYM	Epifactor	RPL30	SIRT6	0.84185293	6.22E-34
THYM	Epifactor	RPL30	BRMS1	0.847867867	7.33E-35
THYM	Epifactor	RPL30	TAF10	0.874833774	1.40E-39
THYM	Epifactor	RPL30	FBL	0.899796018	4.81E-45
THYM	IUPHAR	RPL30	IMPDH2	0.807875828	2.50E-29
THYM	IUPHAR	RPL30	SIRT6	0.84185293	6.22E-34
THYM	IUPHAR	RPL30	SLC27A5	0.858928167	1.12E-36
THYM	TF	RPL30	THAP7	0.808627212	2.02E-29
THYM	TF	RPL30	REXO4	0.810071259	1.34E-29
THYM	TF	RPL30	THAP3	0.811674791	8.50E-30
THYM	TF	RPL30	ZNF787	0.814913651	3.33E-30
THYM	TF	RPL30	ZNF428	0.821534397	4.62E-31
THYM	TF	RPL30	ZNF581	0.830590454	2.71E-32
THYM	TSG	RPL30	GABARAP	0.804956551	5.62E-29
THYM	TSG	RPL30	NPRL2	0.813301918	5.32E-30
THYM	TSG	RPL30	GADD45GIP1	0.834290073	8.08E-33
THYM	TSG	RPL30	TSSC4	0.840262711	1.08E-33
THYM	TSG	RPL30	SIRT6	0.84185293	6.22E-34
THYM	TSG	RPL30	BRMS1	0.847867867	7.33E-35
THYM	TSG	RPL30	GLTSCR2	0.860861211	5.19E-37
THYM	TSG	RPL30	GNB2L1	0.89263861	2.43E-43
UCS	Cell metabolism gene	RPL30	PSMD13	0.801677609	1.38E-28
UCS	Cell metabolism gene	RPL30	PSME1	0.803252873	8.97E-29
UCS	Cell metabolism gene	RPL30	ACOT8	0.803873609	7.57E-29
UCS	Cell metabolism gene	RPL30	GFER	0.803902114	7.51E-29
UCS	Cell metabolism gene	RPL30	EXOSC5	0.805862809	4.37E-29
UCS	Cell metabolism gene	RPL30	TALDO1	0.806210614	3.97E-29
UCS	Cell metabolism gene	RPL30	IMPDH2	0.807875828	2.50E-29
UCS	Cell metabolism gene	RPL30	POLR2H	0.809647644	1.52E-29
UCS	Cell metabolism gene	RPL30	GUK1	0.810985686	1.04E-29
UCS	Cell metabolism gene	RPL30	ITPA	0.813940523	4.42E-30
UCS	Cell metabolism gene	RPL30	TIMM50	0.816409122	2.15E-30
UCS	Cell metabolism gene	RPL30	TOMM22	0.818377963	1.20E-30
UCS	Cell metabolism gene	RPL30	PSMC3	0.81879787	1.06E-30
UCS	Cell metabolism gene	RPL30	PSMB3	0.822976813	2.97E-31
UCS	Cell metabolism gene	RPL30	POLR2I	0.824737079	1.73E-31
UCS	Cell metabolism gene	RPL30	LSM2	0.825962851	1.18E-31
UCS	Cell metabolism gene	RPL30	EXOSC4	0.826124151	1.12E-31
UCS	Cell metabolism gene	RPL30	PSMB7	0.826487015	9.99E-32
UCS	Cell metabolism gene	RPL30	DPM2	0.827310092	7.71E-32
UCS	Cell metabolism gene	RPL30	POLR2F	0.828947938	4.58E-32
UCS	Cell metabolism gene	RPL30	SNRPD3	0.83071506	2.60E-32
UCS	Cell metabolism gene	RPL30	APRT	0.834351363	7.92E-33
UCS	Cell metabolism gene	RPL30	TIMM13	0.850567927	2.72E-35
UCS	Cell metabolism gene	RPL30	TIMM8B	0.857564282	1.91E-36
UCS	Cell metabolism gene	RPL30	SLC27A5	0.858928167	1.12E-36
UCS	Cell metabolism gene	RPL30	PGLS	0.859349339	9.47E-37
UCS	Cell metabolism gene	RPL30	SSR2	0.877518046	4.14E-40
UCS	Cell metabolism gene	RPL30	SNRPD2	0.880390877	1.09E-40
UCS	Cell metabolism gene	RPL30	PFDN5	0.894165454	1.08E-43
UCS	Cell metabolism gene	RPL30	FAU	0.922297032	2.25E-51
UCS	CGC	RPL30	SDHAF2	0.801327144	1.51E-28
UCS	CGC	RPL30	TFPT	0.816767832	1.93E-30
UCS	Epifactor	RPL30	EXOSC5	0.805862809	4.37E-29
UCS	Epifactor	RPL30	CCDC101	0.81073698	1.11E-29
UCS	Epifactor	RPL30	NOC2L	0.811859518	8.06E-30
UCS	Epifactor	RPL30	TFPT	0.816767832	1.93E-30
UCS	Epifactor	RPL30	ZNHIT1	0.818347511	1.21E-30
UCS	Epifactor	RPL30	EXOSC4	0.826124151	1.12E-31
UCS	Epifactor	RPL30	PRPF31	0.827219842	7.93E-32
UCS	Epifactor	RPL30	C17orf49	0.841273494	7.61E-34
UCS	Epifactor	RPL30	SIRT6	0.84185293	6.22E-34
UCS	Epifactor	RPL30	BRMS1	0.847867867	7.33E-35
UCS	Epifactor	RPL30	TAF10	0.874833774	1.40E-39
UCS	Epifactor	RPL30	FBL	0.899796018	4.81E-45
UCS	IUPHAR	RPL30	IMPDH2	0.807875828	2.50E-29
UCS	IUPHAR	RPL30	SIRT6	0.84185293	6.22E-34
UCS	IUPHAR	RPL30	SLC27A5	0.858928167	1.12E-36
UCS	TF	RPL30	THAP7	0.808627212	2.02E-29
UCS	TF	RPL30	REXO4	0.810071259	1.34E-29
UCS	TF	RPL30	THAP3	0.811674791	8.50E-30
UCS	TF	RPL30	ZNF787	0.814913651	3.33E-30
UCS	TF	RPL30	ZNF428	0.821534397	4.62E-31
UCS	TF	RPL30	ZNF581	0.830590454	2.71E-32
UCS	TSG	RPL30	GABARAP	0.804956551	5.62E-29
UCS	TSG	RPL30	NPRL2	0.813301918	5.32E-30
UCS	TSG	RPL30	GADD45GIP1	0.834290073	8.08E-33
UCS	TSG	RPL30	TSSC4	0.840262711	1.08E-33
UCS	TSG	RPL30	SIRT6	0.84185293	6.22E-34
UCS	TSG	RPL30	BRMS1	0.847867867	7.33E-35
UCS	TSG	RPL30	GLTSCR2	0.860861211	5.19E-37
UCS	TSG	RPL30	GNB2L1	0.89263861	2.43E-43

Top

Protein structure

Protein 3D structure
Visit iCn3D.

Top

Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL30	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL30	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL30	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL30	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL30	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL30	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL30	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL30	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL30	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL30	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL30	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL30	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL30	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL30	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL30	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL30	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL30	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL30	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL30	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL30	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL30	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL30	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL30	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL30	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL30	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL30	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL30	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL30	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL30

MAP3K1, NFKB2, POU5F1, MME, NOP56, NEDD4L, VHL, RAD21, ARRB2, SIRT7, CUL3, CUL4B, CDK2, CUL1, COPS5, CAND1, APP, RPS11, RPL4, RPL6, RPS13, RPL8, RPL10A, RPL12, RPL15, RPL18A, RPL19, RPL37A, RPL5, RPL7A, RPL7, RPS14, RPS15A, RPS24, RPS2, RPS5, RPS8, RPSA, RPL11, RPL18, RPS6, RPL31, RPS4X, RPS7, RPS9, RPS23, RPL23, RPL23A, RPL27, RPS3, RPL22, RPL36, RPL21, RPL13, RPL14, RPL10, RPS3A, RPLP0, RPL27A, RPS16, RPL35, RPS26, RPL38, EEF1A1, RPS29, RPS21, RPL37, NHP2L1, NOP58, HNRNPM, HNRNPU, RPLP0P6, NIFK, RPL10L, NOP2, BOP1, KAT5, PA2G4, FN1, VCAM1, IL7R, UBL4A, ITGA4, PAN2, IGSF8, ICAM1, CASP2, OAS1, MAP2K7, RPL13A, G0S2, FAM120B, ZFAND2A, USP14, WWOX, ZBTB1, AURKA, CEP250, CEP57, CEP76, TP53, VCP, PHF6, EED, UBC, UNK, EEF1A2, POLR1B, POLR3B, RPL24, RPL26, RPL26L1, RPL3, RPL34, RPL3L, RPLP1, RPS10, RPS12, RPS15, RPS19, RPS20, RPS25, RPS27, RPL9, RPLP2, RPS18, LOC101929876, FOSL2, C10orf12, LDHD, Rpl35, Srp72, Rrbp1, SKI, MCM2, RC3H1, HIST1H1C, HIST1H1T, RRP8, KIAA0020, RBM34, RBM28, NSA2, REXO4, ZC3HAV1, ZNF184, PPAN-P2RY11, WHSC1, PAK1IP1, FTSJ3, BRIX1, ZNF512, ZNF70, DDX24, ZNF354A, GTPBP4, CCDC137, DDX31, DDX27, GNL2, ZC3H10, ZFP62, PRDM15, EBNA1BP2, RPL32, GLYR1, ZNF22, DKC1, STAU1, NSUN4, RPF1, NIP7, RPF2, MAK16, IMP4, ZNF189, NMNAT1, CNBP, CENPN, DHX30, HP1BP3, TTF1, MYBBP1A, FCF1, RPL28, NLE1, ZNF771, ZNF668, ZSCAN25, ZNF574, TAF1A, LLPH, DDX10, PRKRA, ZNF142, DDX21, GZF1, LYAR, RPL7L1, PAPD5, SURF6, GPATCH4, RSL24D1, SMARCA5, DDX56, PTPN6, CYLD, INO80B, COX15, DLD, DLST, DNM1L, HSD17B10, PDHA1, SDHA, SOD1, VDAC1, FOXA1, TRIM25, BRCA1, C14orf2, FAM50A, MBTPS2, NEMF, PSMD1, PSMD12, SNAPC1, TUBB, WDR7, ACO2, TMPO, PPP1CC, KRAS, MAP2K3, YAF2, CTNNB1, HDAC4, MATN2, PCBP1, PPIE, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, CHD4, SPDL1, RIOK1, HEXIM1, MEPCE, LARP7, HERC2, RECQL4, REST, MYC, CDK9, Prkaa1, Prkab1, RPS6KB2, RC3H2, PHB, RBX1, NR2C2, VRK1, VAMP5, SNRNP70, Dppa3, ITFG1, HMGB1, BIRC3, NFX1, WWP2, Dnajc17, SOX2, CMTR1, ARIH2, PLEKHA4, FANCD2, NGB, PTEN, HCVgp1, ZC3H18, NCK1, WHSC1L1, ARMC7, HN1L, HUWE1, SLC12A6, SPTB, DNHD1, FLNC, E, M, nsp13, nsp14, nsp3, nsp4, nsp5, nsp6, ORF3a, ORF6, ORF7a, ORF7b, ERCC6, MAP1LC3B, UBR5, DUX4, CIT, GRSF1, INS, BRD4, Apc2, RBM39, FBP1, GLI1, RIN3, DNAJC1, DNAJC2, DNAJC8, KDM4C, FBRS, DDX58, OGT, DDRGK1, SPOP, PARK2, UFL1, TRIM37, UBQLN1, FZR1, WDR5, PAGE4, MAP4K3, MAP4K4, MAP4K5, MINK1, NUDCD2, NAA40, ABT1, RSL1D1, ZNF48, ZNF770, ADARB1, RRS1, C7orf50, RPL17, NCL, SPTY2D1, CEBPZ, SRP72, DDX54, RRP15, C8orf33, CTCF, KNOP1, NKRF, FAM111A, POP1, BUD13, ZBTB11, HIST1H2AG, PRKRIR, BMS1, RPL36AL, WDR74, HIST2H2AB, DDX50, GLTSCR2, XRN1, BTF3, FBXW7, RCHY1, N,

Top

Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL30	SKCM	chr8	99057237	99057237	G	A	Missense_Mutation	p.T34I	2
RPL30	KIRC	chr8	99054891	99054891	G	C	Missense_Mutation	p.L94V	2
RPL30	KIRC	chr8	99054939	99054939	T	C	Missense_Mutation	p.N78D	2
RPL30	ESCA	chr8	99054886	99054886	A	-	Frame_Shift_Del	p.I96fs	2
RPL30	ESCA	chr8	99057647	99057647	G	A	Missense_Mutation		1
RPL30	ESCA	chr8	99054886	99054886	A	-	Frame_Shift_Del	p.A95fs	1
RPL30	LIHC	chr8	99054966	99054966	T	-	Frame_Shift_Del	p.T69fs	1
RPL30	LUAD	chr8	99054972	99054972	C	A	Missense_Mutation	p.A67S	1
RPL30	LUAD	chr8	99057586	99057586	C	G	Missense_Mutation	p.A4P	1
RPL30	LUAD	chr8	99054903	99054904	TG	-	Frame_Shift_Del	p.Y89fs	1
RPL30	COAD	chr8	99054081	99054081	A	-	Splice_Site	.	1
RPL30	LUSC	chr8	99057209	99057209	C	A	Silent	p.A43A	1
RPL30	OV	chr8	99126421	99126421	G	C	Nonsense_Mutation	p.Y31*	1
RPL30	ESCA	chr8	99054886	99054886	A	-	Frame_Shift_Del		1
RPL30	SARC	chr8	99057192	99057192	G	T	Missense_Mutation		1

Copy number variation (CNV) of RPL30
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL30
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
95025	BRCA	TCGA-A2-A1G0-01A	ALG2	chr9	101984074	-	RPL30	chr8	99057626	-
95025	ESCA	TCGA-L5-A8NK	ARHGAP10	chr4	148944564	+	RPL30	chr8	99057627	-
95025	STAD	TCGA-CD-A48C-01A	CLASRP	chr19	45543569	+	RPL30	chr8	99057627	-
95025	UCEC	TCGA-A5-A2K5-01A	CPSF6	chr12	69656342	+	RPL30	chr8	99054078	-
95025	N/A	FN070105	EGFL6	chrX	13592994	-	RPL30	chr8	99057165	+
95025	BRCA	TCGA-B6-A1KN-01A	EIF3E	chr8	109260842	-	RPL30	chr8	99055003	-
95025	BLCA	TCGA-E7-A6ME-01A	EMP2	chr16	10641397	-	RPL30	chr8	99057627	-
95025	SKCM	TCGA-D3-A1Q1-06A	ERBB3	chr12	56497283	-	RPL30	chr8	99058697	-
95025	OV	TCGA-13-0899	FBXL7	chr5	15616181	+	RPL30	chr8	99054078	-
95025	N/A	AA603393	GAS7	chr17	9883168	-	RPL30	chr8	99053949	+
95025	KIRP	TCGA-A4-A5Y1-01A	ITM2B	chr13	48835524	-	RPL30	chr8	99058697	-
95025	ESCA	TCGA-L5-A4OQ	KIAA0232	chr4	6826411	+	RPL30	chr8	99057627	-
95025	STAD	TCGA-BR-A44T	LCOR	chr10	98667504	+	RPL30	chr8	99055003	-
95025	N/A	BF923959	MEGF11	chr15	66459306	+	RPL30	chr8	99057773	-
95025	N/A	BI334582	NOP58	chr2	203149104	-	RPL30	chr8	99057760	-
95025	STAD	TCGA-D7-A4Z0-01A	POP1	chr8	99146264	+	RPL30	chr8	99055003	-
95025	N/A	AX341424	RDH10	chr8	74235434	+	RPL30	chr8	99057248	-
95025	N/A	EC578843	RNF10	chr12	120990771	-	RPL30	chr8	99057219	-
92177	GBM	TCGA-14-1402-02A	RPL30	chr8	99054873	-	GOLIM4	chr3	167728611	-
102980	OV	TCGA-24-1471	RPL30	chr8	99057170	-	GUK1	chr1	228336365	+
76433	N/A	BU526643	RPL30	chr8	99053947	-	IMMP1L	chr11	31528209	+
93724	N/A	BQ221159	RPL30	chr8	99054945	-	KCTD18	chr2	201353840	-
101343	N/A	BU526580	RPL30	chr8	99053947	-	LATS2	chr13	21593813	+
101913	N/A	BP226855	RPL30	chr8	99053946	-	NCOA6	chr20	33282555	+
92611	N/A	BG575721	RPL30	chr8	99053947	-	NRXN3	chr14	78646502	-
98714	SARC	TCGA-SI-A71Q-01A	RPL30	chr8	99057171	-	PPHLN1	chr12	42768665	+
76433	N/A	CF122577	RPL30	chr8	99054959	-	PRR3	chr6	30529479	+
95025	N/A	BU608418	RPL30	chr8	99054011	+	RPL30	chr8	99054939	-
76433	N/A	CF124178	RPL30	chr8	99053953	-	SLC25A16	chr10	70267240	-
91964	N/A	CD389544	RPL30	chr8	99053949	-	SNX29	chr16	12201218	-
100933	N/A	DB125840	RPL30	chr8	99057575	-	TBC1D5	chr3	17349627	-
96720	N/A	AV682491	RPL30	chr8	99053947	-	UHRF1BP1	chr6	34817220	-
99698	N/A	BP227240	RPL30	chr8	99053949	-	XPO6	chr16	28162499	+
95025	HNSC	TCGA-BA-A6DL-01A	S100A2	chr1	153533816	-	RPL30	chr8	99058697	-
95025	UCEC	TCGA-D1-A179-01A	SLC39A14	chr8	22262493	+	RPL30	chr8	99058032	-
95025	N/A	AA491890	SMG1	chr16	18906002	-	RPL30	chr8	99053949	+
95025	N/A	AW662691	TP53BP2	chr1	223968077	+	RPL30	chr8	99057760	-
95025	N/A	BG180512	TTC37	chr5	94861108	-	RPL30	chr8	99057248	-

Top

Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

Top

Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	RPL30	0.000445849739191675	0.012

Top

Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL30	0.0235768351527594	0.73
LGG	RPL30	0.0139575674301854	0.45
PRAD	RPL30	0.00976418580544821	0.32
PAAD	RPL30	0.0390657250484741	1

Top

Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source