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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL27A (NCBI Gene ID:6157)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL27A
	Gene ID: 6157
	Gene Symbol	RPL27A
	Gene ID	6157
	Gene Name	ribosomal protein L27a
	Synonyms	L27A
	Cytomap	11p15.4
	Type of Gene	protein-coding
	Description	60S ribosomal protein L27alarge ribosomal subunit protein uL15
	Modification date	20200327
	UniProtAcc	P46776

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL27A	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL27A[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL27A	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000314138	8705552	8705628	Frame-shift
ENST00000314138	8706264	8706439	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRP	RPL27A	-1.08412054314666	0.000280400272458792
COAD	RPL27A	1.10401148181609	0.0291509032249451
STAD	RPL27A	1.38102128420159	0.0341199110262096
KIRC	RPL27A	-2.44303111692082	1.37975994778687e-09
HNSC	RPL27A	1.53683147949011	7.17597035873042e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
STAD	RPL27A	-0.061599414	0.005986474
KICH	RPL27A	0.044791585	0.023905239
TGCT	RPL27A	0.050514062	0.046534515

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL27A (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	Cell metabolism gene	RPL27A	FAU	0.808562794	2.05E-19
DLBC	Cell metabolism gene	RPL27A	POLR2I	0.801826192	7.46E-12
DLBC	Cell metabolism gene	RPL27A	GEMIN7	0.805276181	5.18E-12
DLBC	Cell metabolism gene	RPL27A	HSCB	0.80564002	4.99E-12
DLBC	Cell metabolism gene	RPL27A	POLR2J	0.815832878	1.62E-12
DLBC	Cell metabolism gene	RPL27A	TIMM13	0.818508617	1.20E-12
DLBC	Cell metabolism gene	RPL27A	PTDSS2	0.821875183	8.09E-13
DLBC	Cell metabolism gene	RPL27A	GFER	0.823514685	6.66E-13
DLBC	Cell metabolism gene	RPL27A	POLR2L	0.824981634	5.59E-13
DLBC	Cell metabolism gene	RPL27A	PSMD13	0.826112987	4.88E-13
DLBC	Cell metabolism gene	RPL27A	POLR2F	0.84449951	4.60E-14
DLBC	Cell metabolism gene	RPL27A	TOMM22	0.858162984	6.48E-15
DLBC	Cell metabolism gene	RPL27A	TIMM9	0.863847753	2.70E-15
DLBC	Cell metabolism gene	RPL27A	PFDN5	0.87548789	3.93E-16
DLBC	Cell metabolism gene	RPL27A	NME2	0.876348035	3.39E-16
DLBC	Cell metabolism gene	RPL27A	SNRPD2	0.885775297	6.07E-17
DLBC	Cell metabolism gene	RPL27A	FAU	0.914158528	1.16E-19
DLBC	CGC	RPL27A	NACA	0.855935143	9.04E-15
DLBC	Epifactor	RPL27A	TAF10	0.807702077	4.00E-12
DLBC	Epifactor	RPL27A	FBL	0.851304529	1.78E-14
DLBC	TF	RPL27A	THAP7	0.803177735	6.47E-12
DLBC	TF	RPL27A	ZNF444	0.805122065	5.27E-12
DLBC	TF	RPL27A	ZNF581	0.808427322	3.69E-12
DLBC	TF	RPL27A	NME2	0.876348035	3.39E-16
DLBC	TSG	RPL27A	PARK7	0.804697513	5.51E-12
DLBC	TSG	RPL27A	GADD45GIP1	0.844588429	4.55E-14
DLBC	TSG	RPL27A	GNB2L1	0.885870743	5.96E-17
GBM	Cell metabolism gene	RPL27A	TIMM8B	0.806413721	1.24E-40
GBM	Cell metabolism gene	RPL27A	SSR4	0.813607492	6.87E-42
GBM	Cell metabolism gene	RPL27A	PSMD13	0.816584608	2.00E-42
GBM	Cell metabolism gene	RPL27A	PSMB4	0.823386471	1.10E-43
GBM	Cell metabolism gene	RPL27A	NME2	0.82596384	3.54E-44
GBM	Cell metabolism gene	RPL27A	LSM1	0.832752346	1.64E-45
GBM	Cell metabolism gene	RPL27A	PSMB3	0.832878511	1.54E-45
GBM	Cell metabolism gene	RPL27A	PSMA5	0.834954357	5.86E-46
GBM	Cell metabolism gene	RPL27A	SNRPG	0.84485029	4.77E-48
GBM	Cell metabolism gene	RPL27A	FAU	0.878731582	1.73E-56
GBM	Cell metabolism gene	RPL27A	PFDN5	0.882282794	1.62E-57
GBM	Epifactor	RPL27A	DPY30	0.842560108	1.50E-47
GBM	TF	RPL27A	NME2	0.82596384	3.54E-44
HNSC	Cell metabolism gene	RPL27A	PFDN5	0.807693483	1.64E-131
HNSC	Epifactor	RPL27A	TAF10	0.80095826	9.47E-128
KICH	Cell metabolism gene	RPL27A	FAU	0.869126665	5.93E-29
KIRP	Cell metabolism gene	RPL27A	PFDN5	0.835109941	2.53E-85
KIRP	Cell metabolism gene	RPL27A	PSMD13	0.835570211	1.68E-85
KIRP	Cell metabolism gene	RPL27A	SNRPD2	0.885556765	6.49E-109
KIRP	Cell metabolism gene	RPL27A	FAU	0.917729444	9.32E-131
KIRP	Epifactor	RPL27A	FBL	0.837916033	2.05E-86
KIRP	TSG	RPL27A	GADD45GIP1	0.815434909	3.31E-78
LGG	Cell metabolism gene	RPL27A	PFDN5	0.806293501	1.70E-122
LGG	Cell metabolism gene	RPL27A	FAU	0.894023988	2.97E-186
LGG	CGC	RPL27A	NACA	0.81995057	5.07E-130
LGG	TSG	RPL27A	GNB2L1	0.815137041	2.69E-127
LIHC	Cell metabolism gene	RPL27A	PFDN5	0.830990886	2.75E-109
LIHC	Epifactor	RPL27A	FBL	0.820269107	3.40E-104
PAAD	Cell metabolism gene	RPL27A	FAU	0.849184605	4.50E-52
PAAD	Epifactor	RPL27A	TAF10	0.827520066	3.00E-47
PCPG	Cell metabolism gene	RPL27A	FAU	0.801014068	4.36E-43
PRAD	Cell metabolism gene	RPL27A	ZNRD1	0.809027352	1.41E-128
PRAD	Cell metabolism gene	RPL27A	PFDN5	0.810155	3.30E-129
PRAD	Cell metabolism gene	RPL27A	PSMB7	0.815701673	2.25E-132
PRAD	Cell metabolism gene	RPL27A	POLR2I	0.815738173	2.14E-132
PRAD	Cell metabolism gene	RPL27A	POLR2F	0.822335146	2.63E-136
PRAD	Cell metabolism gene	RPL27A	NME2	0.825838995	1.89E-138
PRAD	Cell metabolism gene	RPL27A	TOMM7	0.83203176	2.33E-142
PRAD	Cell metabolism gene	RPL27A	TIMM9	0.837269481	8.61E-146
PRAD	Cell metabolism gene	RPL27A	SNRPD2	0.881835574	4.82E-181
PRAD	Cell metabolism gene	RPL27A	FAU	0.894336667	1.44E-193
PRAD	CGC	RPL27A	NACA	0.847461711	7.79E-153
PRAD	Epifactor	RPL27A	FBL	0.881888754	4.30E-181
PRAD	TF	RPL27A	NME2	0.825838995	1.89E-138
PRAD	TSG	RPL27A	GAS5	0.804853259	2.82E-126
PRAD	TSG	RPL27A	GNB2L1	0.85963062	5.93E-162
READ	Cell metabolism gene	RPL27A	PFDN5	0.807401228	2.42E-25
TGCT	Cell metabolism gene	RPL27A	FAU	0.841941156	4.13E-43
TGCT	Epifactor	RPL27A	TAF10	0.803696529	1.52E-36
THCA	Cell metabolism gene	RPL27A	PFDN5	0.870026176	3.23E-177
THCA	Cell metabolism gene	RPL27A	SNRPD2	0.877196771	9.03E-184
THCA	Cell metabolism gene	RPL27A	FAU	0.915059764	6.05E-227
THCA	Epifactor	RPL27A	FBL	0.842138938	5.29E-155
THCA	TSG	RPL27A	AIP	0.806890002	1.98E-132
THCA	TSG	RPL27A	GNB2L1	0.826204437	3.62E-144
THYM	Cell metabolism gene	RPL27A	LCMT1	0.801955557	1.28E-28
THYM	Cell metabolism gene	RPL27A	ITPA	0.802643233	1.06E-28
THYM	Cell metabolism gene	RPL27A	IMPDH2	0.806853584	3.32E-29
THYM	Cell metabolism gene	RPL27A	GMPPA	0.809128662	1.75E-29
THYM	Cell metabolism gene	RPL27A	POLR2J	0.811528287	8.87E-30
THYM	Cell metabolism gene	RPL27A	PSMC5	0.81471367	3.53E-30
THYM	Cell metabolism gene	RPL27A	TIMM10	0.81587656	2.51E-30
THYM	Cell metabolism gene	RPL27A	LSM2	0.816014596	2.41E-30
THYM	Cell metabolism gene	RPL27A	MVD	0.816452806	2.12E-30
THYM	Cell metabolism gene	RPL27A	B3GAT3	0.821365433	4.86E-31
THYM	Cell metabolism gene	RPL27A	SNRPD3	0.825648614	1.30E-31
THYM	Cell metabolism gene	RPL27A	TALDO1	0.826317484	1.05E-31
THYM	Cell metabolism gene	RPL27A	EXOSC4	0.826788001	9.09E-32
THYM	Cell metabolism gene	RPL27A	ACOT8	0.826965045	8.59E-32
THYM	Cell metabolism gene	RPL27A	POLD4	0.828409899	5.44E-32
THYM	Cell metabolism gene	RPL27A	POLR2F	0.830137076	3.13E-32
THYM	Cell metabolism gene	RPL27A	POLR2I	0.830373652	2.90E-32
THYM	Cell metabolism gene	RPL27A	SMPD2	0.83248843	1.46E-32
THYM	Cell metabolism gene	RPL27A	POLR2H	0.835133268	6.11E-33
THYM	Cell metabolism gene	RPL27A	APRT	0.83513583	6.11E-33
THYM	Cell metabolism gene	RPL27A	PSMC3	0.83626174	4.19E-33
THYM	Cell metabolism gene	RPL27A	PSMB1	0.838128778	2.24E-33
THYM	Cell metabolism gene	RPL27A	PSMD13	0.839273421	1.51E-33
THYM	Cell metabolism gene	RPL27A	TIMM50	0.839606799	1.35E-33
THYM	Cell metabolism gene	RPL27A	PSMB7	0.845200003	1.91E-34
THYM	Cell metabolism gene	RPL27A	PSMB3	0.847344221	8.86E-35
THYM	Cell metabolism gene	RPL27A	NT5C	0.847867396	7.33E-35
THYM	Cell metabolism gene	RPL27A	TIMM13	0.84879775	5.23E-35
THYM	Cell metabolism gene	RPL27A	PGLS	0.855911372	3.62E-36
THYM	Cell metabolism gene	RPL27A	GFER	0.861897065	3.42E-37
THYM	Cell metabolism gene	RPL27A	DPM2	0.874011355	2.02E-39
THYM	Cell metabolism gene	RPL27A	SLC27A5	0.879924771	1.35E-40
THYM	Cell metabolism gene	RPL27A	SNRPD2	0.883084544	3.01E-41
THYM	Cell metabolism gene	RPL27A	SSR2	0.886718515	5.07E-42
THYM	Cell metabolism gene	RPL27A	TIMM8B	0.894421174	9.38E-44
THYM	Cell metabolism gene	RPL27A	PFDN5	0.942558731	5.53E-59
THYM	Cell metabolism gene	RPL27A	FAU	0.961737982	2.53E-69
THYM	CGC	RPL27A	ASPSCR1	0.810356989	1.24E-29
THYM	CGC	RPL27A	TFPT	0.815705727	2.64E-30
THYM	CGC	RPL27A	RBM10	0.82805034	6.10E-32
THYM	Epifactor	RPL27A	SS18L2	0.805173019	5.29E-29
THYM	Epifactor	RPL27A	PPP4C	0.810767041	1.10E-29
THYM	Epifactor	RPL27A	TFPT	0.815705727	2.64E-30
THYM	Epifactor	RPL27A	MBD3	0.821720858	4.36E-31
THYM	Epifactor	RPL27A	CCDC101	0.826786076	9.09E-32
THYM	Epifactor	RPL27A	EXOSC4	0.826788001	9.09E-32
THYM	Epifactor	RPL27A	PRPF31	0.828190359	5.83E-32
THYM	Epifactor	RPL27A	INO80E	0.839213627	1.55E-33
THYM	Epifactor	RPL27A	C17orf49	0.840822917	8.89E-34
THYM	Epifactor	RPL27A	ZNHIT1	0.841368588	7.36E-34
THYM	Epifactor	RPL27A	DMAP1	0.841575975	6.85E-34
THYM	Epifactor	RPL27A	NOC2L	0.852920301	1.13E-35
THYM	Epifactor	RPL27A	SIRT6	0.876624667	6.22E-40
THYM	Epifactor	RPL27A	BRMS1	0.878512779	2.61E-40
THYM	Epifactor	RPL27A	FBL	0.890833403	6.24E-43
THYM	Epifactor	RPL27A	TAF10	0.901123187	2.25E-45
THYM	IUPHAR	RPL27A	IMPDH2	0.806853584	3.32E-29
THYM	IUPHAR	RPL27A	MMP24	0.808616383	2.03E-29
THYM	IUPHAR	RPL27A	MVD	0.816452806	2.12E-30
THYM	IUPHAR	RPL27A	SMPD2	0.83248843	1.46E-32
THYM	IUPHAR	RPL27A	PSMB1	0.838128778	2.24E-33
THYM	IUPHAR	RPL27A	NT5C	0.847867396	7.33E-35
THYM	IUPHAR	RPL27A	SIRT3	0.85645913	2.93E-36
THYM	IUPHAR	RPL27A	SIRT6	0.876624667	6.22E-40
THYM	IUPHAR	RPL27A	SLC27A5	0.879924771	1.35E-40
THYM	TF	RPL27A	ZNF511	0.800055278	2.13E-28
THYM	TF	RPL27A	ZNF580	0.801485553	1.45E-28
THYM	TF	RPL27A	ZBTB48	0.801675868	1.38E-28
THYM	TF	RPL27A	ZNF408	0.803459179	8.47E-29
THYM	TF	RPL27A	AKAP8L	0.810897679	1.06E-29
THYM	TF	RPL27A	ZNF524	0.819546791	8.43E-31
THYM	TF	RPL27A	MBD3	0.821720858	4.36E-31
THYM	TF	RPL27A	ZNF581	0.823237424	2.74E-31
THYM	TF	RPL27A	REXO4	0.836924823	3.36E-33
THYM	TF	RPL27A	THAP7	0.838195626	2.19E-33
THYM	TF	RPL27A	ZNF428	0.843988012	2.94E-34
THYM	TF	RPL27A	ZNF787	0.845005594	2.05E-34
THYM	TF	RPL27A	THAP3	0.850400525	2.90E-35
THYM	TSG	RPL27A	ZBTB48	0.801675868	1.38E-28
THYM	TSG	RPL27A	PARK7	0.803466362	8.46E-29
THYM	TSG	RPL27A	GABARAP	0.813023136	5.77E-30
THYM	TSG	RPL27A	NPRL2	0.844698985	2.29E-34
THYM	TSG	RPL27A	GLTSCR2	0.849308723	4.33E-35
THYM	TSG	RPL27A	SIRT3	0.85645913	2.93E-36
THYM	TSG	RPL27A	GNB2L1	0.865967339	6.45E-38
THYM	TSG	RPL27A	GADD45GIP1	0.874030839	2.00E-39
THYM	TSG	RPL27A	SIRT6	0.876624667	6.22E-40
THYM	TSG	RPL27A	BRMS1	0.878512779	2.61E-40
THYM	TSG	RPL27A	TSSC4	0.884821522	1.29E-41
UCEC	Cell metabolism gene	RPL27A	PFDN5	0.812096556	1.94E-48
UCEC	Cell metabolism gene	RPL27A	FAU	0.82436295	4.52E-51
UCS	Cell metabolism gene	RPL27A	LCMT1	0.801955557	1.28E-28
UCS	Cell metabolism gene	RPL27A	ITPA	0.802643233	1.06E-28
UCS	Cell metabolism gene	RPL27A	IMPDH2	0.806853584	3.32E-29
UCS	Cell metabolism gene	RPL27A	GMPPA	0.809128662	1.75E-29
UCS	Cell metabolism gene	RPL27A	POLR2J	0.811528287	8.87E-30
UCS	Cell metabolism gene	RPL27A	PSMC5	0.81471367	3.53E-30
UCS	Cell metabolism gene	RPL27A	TIMM10	0.81587656	2.51E-30
UCS	Cell metabolism gene	RPL27A	LSM2	0.816014596	2.41E-30
UCS	Cell metabolism gene	RPL27A	MVD	0.816452806	2.12E-30
UCS	Cell metabolism gene	RPL27A	B3GAT3	0.821365433	4.86E-31
UCS	Cell metabolism gene	RPL27A	SNRPD3	0.825648614	1.30E-31
UCS	Cell metabolism gene	RPL27A	TALDO1	0.826317484	1.05E-31
UCS	Cell metabolism gene	RPL27A	EXOSC4	0.826788001	9.09E-32
UCS	Cell metabolism gene	RPL27A	ACOT8	0.826965045	8.59E-32
UCS	Cell metabolism gene	RPL27A	POLD4	0.828409899	5.44E-32
UCS	Cell metabolism gene	RPL27A	POLR2F	0.830137076	3.13E-32
UCS	Cell metabolism gene	RPL27A	POLR2I	0.830373652	2.90E-32
UCS	Cell metabolism gene	RPL27A	SMPD2	0.83248843	1.46E-32
UCS	Cell metabolism gene	RPL27A	POLR2H	0.835133268	6.11E-33
UCS	Cell metabolism gene	RPL27A	APRT	0.83513583	6.11E-33
UCS	Cell metabolism gene	RPL27A	PSMC3	0.83626174	4.19E-33
UCS	Cell metabolism gene	RPL27A	PSMB1	0.838128778	2.24E-33
UCS	Cell metabolism gene	RPL27A	PSMD13	0.839273421	1.51E-33
UCS	Cell metabolism gene	RPL27A	TIMM50	0.839606799	1.35E-33
UCS	Cell metabolism gene	RPL27A	PSMB7	0.845200003	1.91E-34
UCS	Cell metabolism gene	RPL27A	PSMB3	0.847344221	8.86E-35
UCS	Cell metabolism gene	RPL27A	NT5C	0.847867396	7.33E-35
UCS	Cell metabolism gene	RPL27A	TIMM13	0.84879775	5.23E-35
UCS	Cell metabolism gene	RPL27A	PGLS	0.855911372	3.62E-36
UCS	Cell metabolism gene	RPL27A	GFER	0.861897065	3.42E-37
UCS	Cell metabolism gene	RPL27A	DPM2	0.874011355	2.02E-39
UCS	Cell metabolism gene	RPL27A	SLC27A5	0.879924771	1.35E-40
UCS	Cell metabolism gene	RPL27A	SNRPD2	0.883084544	3.01E-41
UCS	Cell metabolism gene	RPL27A	SSR2	0.886718515	5.07E-42
UCS	Cell metabolism gene	RPL27A	TIMM8B	0.894421174	9.38E-44
UCS	Cell metabolism gene	RPL27A	PFDN5	0.942558731	5.53E-59
UCS	Cell metabolism gene	RPL27A	FAU	0.961737982	2.53E-69
UCS	CGC	RPL27A	ASPSCR1	0.810356989	1.24E-29
UCS	CGC	RPL27A	TFPT	0.815705727	2.64E-30
UCS	CGC	RPL27A	RBM10	0.82805034	6.10E-32
UCS	Epifactor	RPL27A	SS18L2	0.805173019	5.29E-29
UCS	Epifactor	RPL27A	PPP4C	0.810767041	1.10E-29
UCS	Epifactor	RPL27A	TFPT	0.815705727	2.64E-30
UCS	Epifactor	RPL27A	MBD3	0.821720858	4.36E-31
UCS	Epifactor	RPL27A	CCDC101	0.826786076	9.09E-32
UCS	Epifactor	RPL27A	EXOSC4	0.826788001	9.09E-32
UCS	Epifactor	RPL27A	PRPF31	0.828190359	5.83E-32
UCS	Epifactor	RPL27A	INO80E	0.839213627	1.55E-33
UCS	Epifactor	RPL27A	C17orf49	0.840822917	8.89E-34
UCS	Epifactor	RPL27A	ZNHIT1	0.841368588	7.36E-34
UCS	Epifactor	RPL27A	DMAP1	0.841575975	6.85E-34
UCS	Epifactor	RPL27A	NOC2L	0.852920301	1.13E-35
UCS	Epifactor	RPL27A	SIRT6	0.876624667	6.22E-40
UCS	Epifactor	RPL27A	BRMS1	0.878512779	2.61E-40
UCS	Epifactor	RPL27A	FBL	0.890833403	6.24E-43
UCS	Epifactor	RPL27A	TAF10	0.901123187	2.25E-45
UCS	IUPHAR	RPL27A	IMPDH2	0.806853584	3.32E-29
UCS	IUPHAR	RPL27A	MMP24	0.808616383	2.03E-29
UCS	IUPHAR	RPL27A	MVD	0.816452806	2.12E-30
UCS	IUPHAR	RPL27A	SMPD2	0.83248843	1.46E-32
UCS	IUPHAR	RPL27A	PSMB1	0.838128778	2.24E-33
UCS	IUPHAR	RPL27A	NT5C	0.847867396	7.33E-35
UCS	IUPHAR	RPL27A	SIRT3	0.85645913	2.93E-36
UCS	IUPHAR	RPL27A	SIRT6	0.876624667	6.22E-40
UCS	IUPHAR	RPL27A	SLC27A5	0.879924771	1.35E-40
UCS	TF	RPL27A	ZNF511	0.800055278	2.13E-28
UCS	TF	RPL27A	ZNF580	0.801485553	1.45E-28
UCS	TF	RPL27A	ZBTB48	0.801675868	1.38E-28
UCS	TF	RPL27A	ZNF408	0.803459179	8.47E-29
UCS	TF	RPL27A	AKAP8L	0.810897679	1.06E-29
UCS	TF	RPL27A	ZNF524	0.819546791	8.43E-31
UCS	TF	RPL27A	MBD3	0.821720858	4.36E-31
UCS	TF	RPL27A	ZNF581	0.823237424	2.74E-31
UCS	TF	RPL27A	REXO4	0.836924823	3.36E-33
UCS	TF	RPL27A	THAP7	0.838195626	2.19E-33
UCS	TF	RPL27A	ZNF428	0.843988012	2.94E-34
UCS	TF	RPL27A	ZNF787	0.845005594	2.05E-34
UCS	TF	RPL27A	THAP3	0.850400525	2.90E-35
UCS	TSG	RPL27A	ZBTB48	0.801675868	1.38E-28
UCS	TSG	RPL27A	PARK7	0.803466362	8.46E-29
UCS	TSG	RPL27A	GABARAP	0.813023136	5.77E-30
UCS	TSG	RPL27A	NPRL2	0.844698985	2.29E-34
UCS	TSG	RPL27A	GLTSCR2	0.849308723	4.33E-35
UCS	TSG	RPL27A	SIRT3	0.85645913	2.93E-36
UCS	TSG	RPL27A	GNB2L1	0.865967339	6.45E-38
UCS	TSG	RPL27A	GADD45GIP1	0.874030839	2.00E-39
UCS	TSG	RPL27A	SIRT6	0.876624667	6.22E-40
UCS	TSG	RPL27A	BRMS1	0.878512779	2.61E-40
UCS	TSG	RPL27A	TSSC4	0.884821522	1.29E-41
UVM	Cell metabolism gene	RPL27A	FAU	0.887936508	4.98E-28
UVM	CGC	RPL27A	NACA	0.808500896	1.21E-19
UVM	Epifactor	RPL27A	FBL	0.868002854	2.00E-25
UVM	TSG	RPL27A	GLTSCR2	0.837372876	3.71E-22
UVM	TSG	RPL27A	GNB2L1	0.85428125	7.19E-24

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL27A	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL27A	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL27A	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL27A	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL27A	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL27A	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL27A	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL27A	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL27A	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL27A	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL27A	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL27A	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL27A	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL27A	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL27A	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL27A	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL27A	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL27A	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL27A	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL27A	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL27A	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL27A	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL27A	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL27A	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL27A	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL27A	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL27A	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL27A	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL27A

AGO4, RBM39, NOP56, EBNA-LP, ISG15, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, RPL11, RPL13, RPL15, RPL18, RPL19, RPL23A, RPL37A, RPL5, RPL6, RPL7A, RPL7, RPS16, RPS25, RPS3A, RPS4X, RPS6, RPS8, RPS3, RPL24, RPS20, RPL12, RPL22, RPL14, RPL30, RPL10, RPL3, RPL35, RPL8, RPL36, RPS2, FAU, RPS27L, GNB2L1, RPL10L, ESR1, MAGOH, EIF4A3, FN1, VCAM1, UBL4A, ITGA4, PAN2, CD81, IGSF8, ICAM1, PRKACB, PEX6, GTF2F2, AGO2, PARP1, AIMP1, AIMP2, DARS, HNRNPA1, HNRNPA2B1, CCAR2, MARS, QARS, RANBP3, ABCF1, DHX9, EEF1E1, EIF2S1, ZBTB1, HUWE1, SIAH1, CUL7, EED, RNF2, LUZP4, EBNA1BP2, RPL10A, RPL17, PABPC1, PES1, RPL13A, RPL18A, RPL21, RPL23, RPL26L1, RPL27, RPL31, RPL32, RPL34, RPL38, RPL3L, RPL4, RPL9, RPLP0, RPLP1, RPLP2, RPS10, RPS11, RPS12, RPS13, RPS14, RPS15, RPS15A, RPS19, RPS23, RPS27, RPS5, RPS9, RPL35A, RPL36AL, RPS18, LOC101929876, RPS26, RPS7, RPSA, UBA52, SFN, PTEN, gag, HIST1H3E, HNRNPU, NPM1, THOC5, EXOSC1, Eif3a, Eif3e, Ktn1, Rpl35, Srp72, MCM2, Ksr1, RC3H1, C3orf17, ZNF746, DUSP22, NCL, CYLD, INO80B, TRIM25, BRCA1, TRIM14, BMP4, CDK9, HNF1B, KRAS, PCBP1, PPIE, PPP6C, TGFB1, TRIP4, PRPF8, EFTUD2, AAR2, PIH1D1, RNF4, CHD3, CHD4, SPDL1, RIOK1, FGF11, HEXIM1, MEPCE, LARP7, AGR2, RECQL4, GPC1, REST, MYC, GRWD1, RC3H2, PHB, RBX1, KIN, USP14, NR2C2, UBQLN2, PPP1CC, VRK1, HIST1H4A, SNRNP70, Dppa3, ITFG1, HMGB1, ABCC6, BIRC3, STAU1, NFX1, WWP2, SOX2, ARIH2, PLEKHA4, PINK1, YAP1, TFCP2, HCVgp1, ZC3H18, PRKCB, RAB5A, EML5, ACACA, CDKN1B, TRMT11, E, M, nsp13, nsp14, nsp4, nsp5, nsp6, ORF3a, ORF6, ORF7a, ORF7b, NEK4, DUX4, CIT, AURKB, CHMP4B, CHMP4C, KIF14, KIF20A, KIF23, PRC1, C1QBP, HNRNPH1, INS, NDN, BRD4, Apc2, FBP1, BKRF1, RIN3, AR, PARK2, UFL1, DDRGK1, TP53, PANX1, FZR1, WDR5, PAGE4, NUDCD2, NAA40, IPO5, MRPL47, MRPS18A, EME1, RIOK2, MALSU1, MRPL44, KIF2A, MRPL24, MRPL4, TSPYL2, GNL3L, DDX24, WDR36, DICER1, MRPL42, MRPL39, MINA, ZNF320, ZNF273, PARN, MRPL28, MRPL2, MRPL20, MRS2, FNTB, ZNF526, GTF3C1, TRMT1L, ZNF770, ZNF100, UIMC1, MRPS31, DDX21, GADD45GIP1, GTF3C2, ZNF708, UBE2O, MRPL32, WDR3, MRPS30, ICT1, BBX, ZNF714, NAP1L1, BLM, RANBP6, MRPS18C, MRPL1, MRPL11, MRPL9, MRPS9, MRPL22, MRPL38, GZF1, NOA1, MRPL16, ZNF430, ZNF253, ADARB1, ZNF48, VPRBP, MRPL49, SRBD1, ZNF493, MRPL55, PRKCI, TOP3B, RBAK, MRPL40, MRPS35, FTSJ3, MRPL18, ZNF496, MRPL45, NBPF1, DHX36, MRPL51, MRPL30, MUS81, ZNF492, RNF220, DDX31, ZNF431, MRPL50, RPF1, ZNF724P, ZNF92, DHX57, MRPL13, PRKRA, ZNF346, MAGEB2, SPRTN, BTF3, FSCN1, FBXW7, RCHY1, CCNF, N, DVL2, RB1CC1, KLF4,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL27A	UCEC	chr11	8707314	8707314	G	C	Missense_Mutation	p.K136N	2
RPL27A	PCPG	chr11	8705560	8705560	C	A	Missense_Mutation	p.H25Q	2
RPL27A	UCEC	chr11	8707323	8707323	T	G	Missense_Mutation	p.S139R	2
RPL27A	KIRC	chr11	8707275	8707275	C	A	Silent	p.I123I	2
RPL27A	LAML	chr11	8662196	8662196	C	T	Silent	p.F45	2
RPL27A	SARC	chr11	8706304	8706304	C	T	Silent		2
RPL27A	LIHC	chr11	8706407	8706407	G	-	Frame_Shift_Del	p.G96fs	2
RPL27A	SKCM	chr11	8706416	8706416	C	T	Missense_Mutation	p.P99S	2
RPL27A	STAD	chr11	8706388	8706388	T	C	Silent		2
RPL27A	STAD	chr11	8706388	8706388	T	C	Silent	p.N89N	2
RPL27A	UCEC	chr11	8706403	8706403	G	C	Missense_Mutation	p.K94N	2
RPL27A	PCPG	chr11	8705560	8705560	C	A	Missense_Mutation		1
RPL27A	COAD	chr11	8706299	8706299	C	T	Missense_Mutation	p.H60Y	1
RPL27A	SARC	chr11	8707250	8707250	G	T	Missense_Mutation		1
RPL27A	SARC	chr11	8707311	8707311	G	T	Missense_Mutation		1
RPL27A	LGG	chr11	8707309	8707309	G	A	Missense_Mutation	p.E135K	1
RPL27A	LIHC	chr11	8704765	8704765	A	G	Missense_Mutation	p.K7R	1
RPL27A	SARC	chr11	8706304	8706304	C	T	Silent	p.Y61Y	1
RPL27A	SARC	chr11	8706304	8706304	C	T	Silent	p.Y61	1
RPL27A	LIHC	chr11	8704780	8704780	G	-	Frame_Shift_Del	p.R12fs	1
RPL27A	LIHC	chr11	8706265	8706265	C	-	Splice_Site	p.Y48_splice	1
RPL27A	LUAD	chr11	8706410	8706410	G	T	Missense_Mutation	p.A97S	1
RPL27A	BLCA	chr11	8707233	8707233	C	T	Silent		1
RPL27A	LUAD	chr11	8704331	8704331	A	T	Translation_Start_Site		1
RPL27A	BLCA	chr11	8704389	8704389	C	G	Missense_Mutation		1

Copy number variation (CNV) of RPL27A
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL27A
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101743	N/A	BP430751	ATP9B	chr18	77131372	-	RPL27A	chr11	8707393	-
101743	N/A	AA572766	EFCAB6-AS1	chr22	43920604	+	RPL27A	chr11	8707395	-
101743	N/A	AA076065	FSIP1	chr15	40049762	-	RPL27A	chr11	8707393	-
101743	N/A	BP430318	JAZF1	chr7	28160147	+	RPL27A	chr11	8707395	-
101743	N/A	CR936817	MAN2C1	chr15	75650097	-	RPL27A	chr11	8705338	+
101743	N/A	BG231088	PIP4K2A	chr10	22998332	+	RPL27A	chr11	8707393	-
92164	STAD	TCGA-BR-8078-01A	RPL27A	chr11	8706439	+	ADAM28	chr8	24211897	+
76338	N/A	GW492875	RPL27A	chr11	8707393	+	CCDC42	chr17	8637829	-
93907	N/A	AW606229	RPL27A	chr11	8707960	-	CUBN	chr10	17129728	-
77602	OV	TCGA-59-2348	RPL27A	chr11	8706439	+	EEF1G	chr11	62339373	-
93731	STAD	TCGA-HU-A4GN-01A	RPL27A	chr11	8706439	+	ERN2	chr16	23714023	-
93941	BRCA	TCGA-D8-A1XW-01A	RPL27A	chr11	8704812	+	MRPL14	chr6	44084366	-
98487	UCEC	TCGA-AX-A2H8	RPL27A	chr11	8705628	+	PARP14	chr3	122446658	+
76338	ESCA	TCGA-VR-AA4G	RPL27A	chr11	8704363	+	ST5	chr11	8747756	-
76338	OV	TCGA-59-2348-01A	RPL27A	chr11	8710416	-	ST5	chr11	8719182	-
95665	N/A	BP228247	RPL27A	chr11	8707395	+	SYCE3	chr22	50993121	+
76338	OV	TCGA-13-1410	RPL27A	chr11	8705628	+	TFG	chr3	100455419	+
101743	N/A	BF218481	TRIM66	chr11	8704805	+	RPL27A	chr11	8704807	+
101745	N/A	GW493378	ZNF268	chr12	133769017	+	RPL27A	chr11	8707398	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LGG	RPL27A	0.0134383398856543	0.38
SARC	RPL27A	0.0311438666306964	0.84
KIRC	RPL27A	0.0356345923594759	0.93

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL27A	0.0314607289193895	0.98
BRCA	RPL27A	0.00110157696272115	0.036
PAAD	RPL27A	0.0246632998995016	0.79
SARC	RPL27A	0.0486064141763545	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0030312	Pancytopenia	1	CTD_human
C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human