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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL31 (NCBI Gene ID:6160)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL31
	Gene ID: 6160
	Gene Symbol	RPL31
	Gene ID	6160
	Gene Name	ribosomal protein L31
	Synonyms	L31
	Cytomap	2q11.2
	Type of Gene	protein-coding
	Description	60S ribosomal protein L31large ribosomal subunit protein eL31
	Modification date	20200313
	UniProtAcc	P62899

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPL31	GO:0002181	cytoplasmic translation	25957688

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL31	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL31[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL31	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000264258	101620619	101620745	In-frame
ENST00000409733	101620619	101620745	In-frame
ENST00000264258	101622420	101622533	Frame-shift
ENST00000409733	101622420	101622533	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000409733	101620619	101620745	842	517	642	125	36	77
ENST00000264258	101620619	101620745	1882	709	834	125	36	77

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P62899	36	77	1	125	Chain	ID=PRO_0000153763;Note=60S ribosomal protein L31
P62899	36	77	1	125	Chain	ID=PRO_0000153763;Note=60S ribosomal protein L31
P62899	36	77	55	55	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P62900
P62899	36	77	55	55	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P62900
P62899	36	77	70	70	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P62900
P62899	36	77	70	70	Modified residue	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P62900
P62899	36	77	75	75	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19608861;Dbxref=PMID:19608861
P62899	36	77	75	75	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19608861;Dbxref=PMID:19608861
P62899	36	77	75	75	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P62900
P62899	36	77	75	75	Modified residue	Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P62900

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
THCA	RPL31	1.09436372419291	0.0152379297688856
PRAD	RPL31	1.37417394483053	0.0209655998648434

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL31 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	CGC	RPL31	NACA	0.835571693	9.36E-13
CHOL	TSG	RPL31	GNB2L1	0.820204042	5.43E-12
DLBC	Cell metabolism gene	RPL31	NME2	0.817820718	1.30E-12
DLBC	Cell metabolism gene	RPL31	PFDN5	0.829402693	3.27E-13
DLBC	Cell metabolism gene	RPL31	SNRPD2	0.845148926	4.21E-14
DLBC	Cell metabolism gene	RPL31	FAU	0.845791751	3.86E-14
DLBC	CGC	RPL31	NACA	0.921160619	1.78E-20
DLBC	TF	RPL31	NME2	0.817820718	1.30E-12
DLBC	TSG	RPL31	GNB2L1	0.898821766	4.31E-18
GBM	TSG	RPL31	GAS5	0.80923664	4.04E-41
LIHC	TSG	RPL31	GNB2L1	0.805409989	1.13E-97
MESO	CGC	RPL31	NACA	0.806320358	4.38E-21
PAAD	Cell metabolism gene	RPL31	FAU	0.816039897	5.86E-45
PRAD	Cell metabolism gene	RPL31	SNRPD2	0.807597793	8.79E-128
PRAD	Cell metabolism gene	RPL31	TIMM9	0.810956844	1.17E-129
PRAD	CGC	RPL31	NACA	0.845238157	2.96E-151
PRAD	Epifactor	RPL31	FBL	0.820624237	2.81E-135
PRAD	TSG	RPL31	GAS5	0.839243774	4.07E-147
PRAD	TSG	RPL31	GNB2L1	0.848326692	1.86E-153
THYM	Cell metabolism gene	RPL31	FAU	0.814268226	4.02E-30
THYM	TSG	RPL31	GNB2L1	0.811159266	9.85E-30
UCS	Cell metabolism gene	RPL31	FAU	0.814268226	4.02E-30
UCS	TSG	RPL31	GNB2L1	0.811159266	9.85E-30
UVM	Cell metabolism gene	RPL31	TIMM9	0.829674289	1.93E-21
UVM	TSG	RPL31	GAS5	0.850417468	1.85E-23

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL31	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL31	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL31	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL31	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL31	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL31	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL31	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL31	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL31	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL31	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL31	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL31	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL31	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL31	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL31	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL31	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL31	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL31	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL31	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL31	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL31	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL31	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL31	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL31	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL31	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL31	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL31	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL31	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL31

EWSR1, MAGEB2, PSTPIP1, PINX1, DDX56, CNBP, LYAR, YWHAZ, WBP5, ASF1B, BRCA1, POU5F1, CACNA1A, NOP56, EBNA-LP, ARRB2, TCF3, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, NEDD8, APP, RPL10A, RPL11, RPL12, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL23A, RPL23, RPL24, RPL27, RPL37A, RPL5, RPL7A, RPL7, RPS10, RPS11, RPS13, RPS14, RPS15A, RPS16, RPS17, RPS19, RPS23, RPS24, RPS26, RPS2, RPS4X, RPS5, RPS6, RPS7, RPS8, RPSA, RPL6, RPL14, RPL30, RPS3A, RPS3, RPS12, RPL9, RPL4, RPL10, RPL35, RPL22, RPLP0, RPL8, RPL17, RPS21, EEF2, EEF1A1, RPS27A, ILF2, DHX9, SLC25A5, EIF4A3, DDX21, ILF3, HNRNPM, NAP1L1, EBNA1BP2, NHP2L1, TUFM, EIF6, MOV10, DHX15, RPLP0P6, RPL10L, MRTO4, NIFK, RBMX, RPS27L, HNRNPR, MOGS, SMURF1, FN1, IFIT2, NOS2, IL7R, UBL4A, PAN2, CD81, IGSF8, ICAM1, BLVRB, CRKL, GPR20, TARDBP, CEP250, CEP76, TP53, TUBG1, TUBGCP3, EED, RNF2, DDX27, PES1, RPL13, RPL13A, RPL27A, RPL3, FTSJ3, RPLP2, RPS15, RPS18, RPS20, SRP68, RPL34, RPL35A, RPL36, RPL38, RPLP1, RPS25, LOC101929876, RPS27, RPS9, SSB, PTEN, HIST1H3E, AHSA1, Srp72, Prpf3, Brwd3, MCM2, Ksr1, RRS1, NCL, CYLD, INO80B, TRIM25, CLEC14A, TRIM14, RMND5A, ACO2, PCBP1, ADSS, BMP4, CTNNB1, KRAS, MTCH2, VPS4B, PRPF8, EFTUD2, AAR2, PIH1D1, RPTOR, TNIP2, RNF4, CHD3, CHD4, LARP7, SPDL1, RIOK1, HEXIM1, MEPCE, SNAI1, AGR2, RECQL4, REST, MYC, CDK9, Prkaa1, Prkab1, FBL, HIST1H3A, GRWD1, METTL14, KIAA1429, EIF4B, RC3H1, RC3H2, PHB, CTCF, NR2C2, PPP1CC, VRK1, HIST1H4A, SNRNP70, ITFG1, HMGB1, BIRC3, STAU1, NFX1, WWP2, PLEKHA4, YAP1, TFCP2, FANCD2, HCVgp1, ZC3H18, GRB7, HIST1H1C, ADNP, SNIP1, SMG7, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, INS, BRD4, N, Apc2, RBM39, FBP1, MKRN1, RAD51, SETD8, TSPYL5, LIN28A, POU2F1, PARK2, UFL1, DDRGK1, AATF, ANKRD11, ANP32E, ATAD5, BBX, BLM, BMS1, BOP1, BRD3, BRIX1, BTF3, BTF3L4, BUD13, BUD31, C18orf21, C18orf25, C1orf131, C1orf35, CCDC137, CCDC47, CDK11A, CEBPZ, CENPC, CKAP4, CMSS1, COIL, CXorf56, CXorf57, DDX10, DDX18, DDX24, DDX31, DDX49, DDX5, DDX50, DDX52, DDX54, DDX55, DHX33, DHX37, DKC1, DNTTIP2, TCEB3, ERCC5, ESF1, ETFA, EXOSC10, EXOSC9, FAM207A, FRG1, GNL2, GNL3, GNL3L, GPATCH4, GTF2F1, GTPBP4, H1FX, HEATR1, HELLS, HIST1H1E, HMGN2, HNRNPAB, HNRNPC, IPO5, IPO7, ISG20L2, IWS1, KIN, KNOP1, KRI1, KRR1, LAS1L, LENG8, LIG3, LLPH, LRRC59, MAK16, MCM10, MFAP1, MKI67, MPHOSPH10, SKIV2L2, MYBBP1A, NACA, NAT10, C17orf85, C3orf17, NGDN, C11orf57, NKRF, NMT1, NOC2L, NOC3L, NOL10, NOL11, NOL6, NOL8, NOL9, NOLC1, NOM1, NOP14, NOP2, GLTSCR2, NOP58, NPM1, NPM3, NVL, PAPD5, PARN, PDCD11, PFKP, PHF2, PHF8, POLR1E, POP1, PPAN-P2RY11, PPM1G, PRPF31, PRPF6, PSME2, PTDSS1, KIAA0020, RAD18, RALY, RBM19, RBM28, RBM34, RECQL5, REXO4, RPP38, RRP1, RRP12, RRP15, RRP1B, RRP7A, RRP8, RSBN1, RSBN1L, RSL1D1, SDAD1, SENP3, SET, SLU7, SPTY2D1, SRFBP1, SRPK1, STRBP, STT3B, SUPT6H, SURF6, TAF3, TBL3, TCOF1, TEX10, TOP2B, TSR1, TXLNG, TXNL1, UBTF, UPF3B, URB1, URB2, USP36, UTP14A, UTP18, UTP20, UTP3, VRK2, WBP11, WDR3, WDR36, WDR43, WRN, XPO5, XRN2, YTHDC1, ZMAT2, ZNF106, ZNF136, ZNF24, ZNF346, ZSCAN21, BRD2, DDX41, DHX8, E2F6, EDF1, FAM50A, FANCI, FEN1, GTF2F2, IK, KIAA1143, NAA35, NAP1L4, NCAPD3, NSD1, WHSC1, WHSC1L1, NUP188, PAF1, PDS5B, PHF10, PPIL2, PRPF3, RFC1, RP9, RRBP1, RTF1, SCAF1, SRP54, SRPK2, SRPR, SUPT16H, SUPT5H, TAF1, TOP1, TOP2A, TRMT1L, UVSSA, XRCC6, ZC3H13, ZNF512, ZNF512B, ZRANB2, TRIM37, ATG7, ATG3, USP15, UBQLN1, FZR1, NUDCD2, RPL26L1, SRSF5, HIST1H1D, PRDM15, HIST1H1B, PRDM10, ZNF16, ADARB1, RPL26, ZNF689, YBX1, ZC3HAV1, YTHDC2, ZCCHC6, EPB41L5, NOC4L, TRIM71, CCDC86, RPS28, ZCCHC3, STAU2, BAZ2A, YBX3, ZFX, LARP1B, FARS2, PRR3, RPL36AL, HIST1H1T, ZCRB1, ZNF184, RPSAP58, DHX57, PABPC4L, TOE1, ZSCAN25, PRKRA, KBTBD6, APOBEC3F, SRSF6, FAM120A, MRPL16, MRPS17, LARP1, ZFR, ZNF770, ZNF668, RPF1, NOL12, LTV1, GLYR1, EPB41L4B, YTHDF1, IMP3, HIST2H2AB, HIST1H2AG, MRPL13, LUC7L, ZFP91, U2SURP, ZC3H8, NGRN, PAK1IP1, WBSCR16, PURB, PURA, FCF1, ABT1, FAM111A, CHERP, CCDC59, HIST1H2AE, DHX16, TRUB2, SREK1, GADD45GIP1, TTF1, YBX2, ZBTB11, UPF1, ZNF574, DIMT1, DHX36, RPL7L1, RPF2, MDM2, UTP23, SPATS2L, METTL17, SF3B1, MRPS14, APOBEC3D, ZBTB24, RSL24D1, IMP4, NSA2, NOP16, SLFN11, FBXW7, EIF4ENIF1, CCNF, KLF16,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPL31	chr2	101619283	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL31	chr2	101619321	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL31	chr2	101619332	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL31	chr2	101619377	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL31	chr2	101620766	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL31	chr2	101622231	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL31	chr2	101622439	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL31	chr2	101622627	C	A	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
RPL31	chr2	101622728	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
RPL31	chr2	101624332	A	AAAG	Duplication	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001821\|inframe_insertion,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001821\|inframe_insertion,SO:0001627\|intron_variant
RPL31	chr2	101624526	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL31	chr2	101627925	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
RPL31	chr2	101635287	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL31	chr2	101635369	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL31	chr2	101635538	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL31	BLCA	chr2	101622476	101622476	G	A	Missense_Mutation	p.D97N	2
RPL31	ESCA	chr2	101622446	101622446	C	T	Missense_Mutation	p.R87W	2
RPL31	STAD	chr2	101620636	101620636	G	A	Missense_Mutation	p.A42T	2
RPL31	BLCA	chr2	101622467	101622467	G	A	Missense_Mutation	p.E94K	2
RPL31	ESCA	chr2	101622446	101622446	C	T	Missense_Mutation		2
RPL31	BLCA	chr2	101622473	101622473	G	A	Missense_Mutation	p.E96K	2
RPL31	HNSC	chr2	101622470	101622470	G	A	Missense_Mutation	p.D95N	2
RPL31	KIRC	chr2	101622534	101622534	G	C	Missense_Mutation	p.S116T	2
RPL31	CESC	chr2	101619193	101619193	G	T	Missense_Mutation	p.K10N	1
RPL31	LIHC	chr2	101622816	101622816	A	G	Silent		1
RPL31	BLCA	chr2	101622476	101622476	G	A	Missense_Mutation		1
RPL31	COAD	chr2	101622439	101622439	C	T	Silent	p.I84I	1
RPL31	LUAD	chr2	101619266	101619266	G	T	Nonsense_Mutation	p.G35*	1
RPL31	BLCA	chr2	101622832	101622832	G	A	Missense_Mutation		1
RPL31	COAD	chr2	101635498	101635498	T	C	Missense_Mutation	p.X129Q	1
RPL31	PRAD	chr2	101619172	101619172	C	A	Silent	p.P3P	1
RPL31	BLCA	chr2	101620642	101620642	C	A	Silent		1
RPL31	DLBC	chr2	101619211	101619211	C	T	Silent	p.A16A	1
RPL31	SARC	chr2	101622819	101622819	G	T	Missense_Mutation		1
RPL31	HNSC	chr2	101622470	101622470	G	A	Missense_Mutation		1
RPL31	BLCA	chr2	101622832	101622832	G	A	Missense_Mutation	p.D123N	1
RPL31	HNSC	chr2	101620626	101620626	C	A	Missense_Mutation		1
RPL31	BLCA	chr2	101620654	101620654	G	C	Missense_Mutation	p.E48Q	1
RPL31	BLCA	chr2	101620642	101620642	C	A	Silent	p.R44R	1
RPL31	HNSC	chr2	101620626	101620626	C	A	Missense_Mutation	p.F38L	1
RPL31	BLCA	chr2	101622467	101622467	G	A	Missense_Mutation		1
RPL31	CESC	chr2	101619193	101619193	G	T	Missense_Mutation		1
RPL31	BLCA	chr2	101622473	101622473	G	A	Missense_Mutation		1

Copy number variation (CNV) of RPL31
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL31
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
103186	COAD	TCGA-AA-3930-01A	ALDH2	chr12	112221074	+	RPL31	chr2	101619194	+
103186	READ	TCGA-AG-3599	CCDC8	chr19	46913667	-	RPL31	chr2	101622507	+
103186	N/A	CB054929	CD99	chrY	2567529	+	RPL31	chr2	101623694	+
103186	N/A	AA731080	DENND5B-AS1	chr12	31750088	+	RPL31	chr2	101622885	-
103186	N/A	AA886853	DPY19L2P2	chr7	102846089	-	RPL31	chr2	101622880	-
103186	N/A	BG223223	DPYD	chr1	97934945	-	RPL31	chr2	101622880	-
103186	N/A	AA420710	DYSF	chr2	71865489	-	RPL31	chr2	101622880	-
103186	N/A	AA528275	GPN3	chr12	110898802	-	RPL31	chr2	101622880	-
103186	N/A	CF122738	NDUFA1	chrX	119005973	+	RPL31	chr2	101622852	+
103186	BRCA	TCGA-A7-A26F-01A	NPAS2	chr2	101436876	+	RPL31	chr2	101620620	+
103186	STAD	TCGA-CD-8527-01A	NPHP1	chr2	110962477	-	RPL31	chr2	101622421	+
103186	N/A	BP429555	PLIN5	chr19	4527547	-	RPL31	chr2	101622885	-
101332	N/A	EC505710	RPL31	chr2	101619261	+	AIG1	chr6	143648453	+
102309	N/A	AV687623	RPL31	chr2	101622880	+	ALB	chr4	74274463	+
102627	N/A	AV692295	RPL31	chr2	101622880	+	DPYD	chr1	97934945	+
100195	N/A	BI858450	RPL31	chr2	101622880	+	EFCAB6	chr22	43944419	+
102564	N/A	CF123956	RPL31	chr2	101622880	+	FAM174B	chr15	93262994	+
76492	N/A	AA225427	RPL31	chr2	101619167	-	GPN3	chr12	110899206	-
76492	N/A	AA715413	RPL31	chr2	101622880	+	GPN3	chr12	110898802	+
76492	N/A	CF123602	RPL31	chr2	101622881	+	GPN3	chr12	110898770	+
76492	STAD	TCGA-BR-A4QI-01A	RPL31	chr2	101622533	+	HCN3	chr1	155259182	+
101638	N/A	BP377902	RPL31	chr2	101622880	+	HNRNPC	chr14	21699201	-
91172	N/A	AI541289	RPL31	chr2	101622878	+	KATNAL1	chr13	30804127	-
95269	N/A	BG031488	RPL31	chr2	101622885	+	KIAA0556	chr16	27676944	-
101525	N/A	DB263110	RPL31	chr2	101619203	+	MYLK	chr3	123331867	-
93917	N/A	BM014408	RPL31	chr2	101622880	+	N4BP2	chr4	40087776	-
102052	N/A	BU602013	RPL31	chr2	101619199	+	NCEH1	chr3	172349060	-
100629	LIHC	TCGA-G3-A7M7-01A	RPL31	chr2	101622533	+	NPAS2	chr2	101611862	+
87484	N/A	AA225391	RPL31	chr2	101622881	+	RNF150	chr4	141903698	-
76492	N/A	NM_001099693	RPL31	chr2	101622885	+	RPL31P11	chr1	161655057	-
100926	N/A	EC486496	RPL31	chr2	101620703	-	RPTOR	chr17	78576488	+
79420	N/A	CF124806	RPL31	chr2	101622880	+	RUNX2	chr6	45499927	-
76492	N/A	BP226307	RPL31	chr2	101622880	+	SERHL	chr22	42904321	+
96490	N/A	AA225466	RPL31	chr2	101622881	+	STK10	chr5	171528477	+
83223	N/A	AA885974	RPL31	chr2	101622880	+	ZNF341	chr20	32339953	-
83223	N/A	CF123481	RPL31	chr2	101622880	+	ZNF341	chr20	32340477	-
103186	N/A	AI799911	RPL31P11	chr1	161654651	+	RPL31	chr2	101622876	-
103186	N/A	EC557280	RPL31P11	chr1	161654697	-	RPL31	chr2	101622419	+
103186	N/A	EC464523	UBR1	chr15	43343767	-	RPL31	chr2	101622876	-
103186	N/A	CB050760	ZFP64	chr20	50756418	+	RPL31	chr2	101623694	+
103186	N/A	EC540825	ZP1	chr11	60637459	-	RPL31	chr2	101619164	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPL31	0.00973483486700517	0.27
BRCA	RPL31	0.0203240264720107	0.55
PAAD	RPL31	0.0289177408225499	0.75
MESO	RPL31	0.034003892455808	0.85

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL31	0.0195660190708521	0.63
BRCA	RPL31	0.0420427114342769	1
PAAD	RPL31	0.0101002400680946	0.33

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1260899	Anemia, Diamond-Blackfan	2	GENOMICS_ENGLAND
C0006142	Malignant neoplasm of breast	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C4704874	Mammary Carcinoma, Human	1	CTD_human