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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL32 (NCBI Gene ID:6161)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL32
	Gene ID: 6161
	Gene Symbol	RPL32
	Gene ID	6161
	Gene Name	ribosomal protein L32
	Synonyms	L32\|PP9932
	Cytomap	3p25.2
	Type of Gene	protein-coding
	Description	60S ribosomal protein L32large ribosomal subunit protein eL32
	Modification date	20200313
	UniProtAcc	P62910

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPL32	GO:0002181	cytoplasmic translation	25957688

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL32	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL32[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL32	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000396953	12880847	12881029	Frame-shift
ENST00000396957	12880847	12881029	Frame-shift
ENST00000429711	12880847	12881029	Frame-shift
ENST00000435983	12880847	12881029	Frame-shift
ENST00000396957	12881640	12881840	3UTR-3CDS
ENST00000435983	12881640	12881852	3UTR-3CDS

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
COAD	RPL32	2.10930675863764	0.00322914123535157
STAD	RPL32	2.08355685326952	0.00879816571250558
PRAD	RPL32	1.36027364301933	0.0190254949499432
KIRP	RPL32	-1.10565812377306	4.39747236669064e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KICH	RPL32	-0.027427024	0.015411438
STAD	RPL32	-0.080156499	0.019770924

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL32 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	RPL32	POLR2J	0.802234143	7.15E-12
DLBC	Cell metabolism gene	RPL32	PSMB3	0.805024935	5.32E-12
DLBC	Cell metabolism gene	RPL32	DGUOK	0.809116739	3.43E-12
DLBC	Cell metabolism gene	RPL32	POLR2F	0.809520216	3.28E-12
DLBC	Cell metabolism gene	RPL32	TIMM13	0.811572513	2.62E-12
DLBC	Cell metabolism gene	RPL32	GEMIN7	0.824668007	5.80E-13
DLBC	Cell metabolism gene	RPL32	TOMM7	0.8268995	4.44E-13
DLBC	Cell metabolism gene	RPL32	GFER	0.831101687	2.64E-13
DLBC	Cell metabolism gene	RPL32	ECHS1	0.832592094	2.19E-13
DLBC	Cell metabolism gene	RPL32	SNRPD2	0.839520062	8.98E-14
DLBC	Cell metabolism gene	RPL32	PGLS	0.843942839	4.97E-14
DLBC	Cell metabolism gene	RPL32	NME2	0.848235109	2.75E-14
DLBC	Cell metabolism gene	RPL32	TIMM9	0.854613528	1.10E-14
DLBC	Cell metabolism gene	RPL32	FAU	0.883242746	9.77E-17
DLBC	Cell metabolism gene	RPL32	PFDN5	0.885214021	6.75E-17
DLBC	Epifactor	RPL32	FBL	0.806515273	4.54E-12
DLBC	Epifactor	RPL32	ZNHIT1	0.83678274	1.28E-13
DLBC	IUPHAR	RPL32	MMP24	0.81973087	1.04E-12
DLBC	IUPHAR	RPL32	SLC25A26	0.870010086	9.96E-16
DLBC	TF	RPL32	ZNF444	0.806712417	4.45E-12
DLBC	TF	RPL32	ZNF581	0.817595948	1.33E-12
DLBC	TF	RPL32	THAP3	0.827099412	4.33E-13
DLBC	TF	RPL32	ZNF428	0.831288711	2.58E-13
DLBC	TF	RPL32	THAP7	0.841390715	7.01E-14
DLBC	TF	RPL32	NME2	0.848235109	2.75E-14
DLBC	TSG	RPL32	GADD45GIP1	0.847155064	3.19E-14
DLBC	TSG	RPL32	GLTSCR2	0.853561061	1.28E-14
DLBC	TSG	RPL32	GNB2L1	0.897105442	6.23E-18
GBM	Cell metabolism gene	RPL32	SEC13	0.800484235	1.22E-39
GBM	Cell metabolism gene	RPL32	SSR4	0.804991092	2.16E-40
GBM	Cell metabolism gene	RPL32	LSM3	0.806883878	1.03E-40
GBM	Cell metabolism gene	RPL32	FAU	0.808981745	4.47E-41
GBM	Cell metabolism gene	RPL32	SSR2	0.834022234	9.07E-46
GBM	TSG	RPL32	GAS5	0.849679733	4.03E-49
KIRP	Cell metabolism gene	RPL32	FAU	0.830973356	9.45E-84
KIRP	Cell metabolism gene	RPL32	SNRPD2	0.838837422	8.90E-87
LAML	Cell metabolism gene	RPL32	SNRPD2	0.805315473	1.12E-40
LGG	Cell metabolism gene	RPL32	FAU	0.881718447	2.13E-174
LGG	CGC	RPL32	NACA	0.849547694	8.90E-149
LGG	TSG	RPL32	GNB2L1	0.833693069	2.87E-138
LGG	TSG	RPL32	GAS5	0.842754049	3.93E-144
LIHC	Cell metabolism gene	RPL32	PFDN5	0.806318569	4.67E-98
LIHC	TSG	RPL32	GNB2L1	0.82020772	3.63E-104
MESO	TSG	RPL32	GNB2L1	0.800093238	1.46E-20
PAAD	Cell metabolism gene	RPL32	FAU	0.810370114	6.94E-44
PRAD	Cell metabolism gene	RPL32	ZNRD1	0.803102173	2.50E-125
PRAD	Cell metabolism gene	RPL32	POLR2I	0.817090986	3.48E-133
PRAD	Cell metabolism gene	RPL32	PSMB7	0.820191424	5.11E-135
PRAD	Cell metabolism gene	RPL32	POLR2F	0.826764659	5.04E-139
PRAD	Cell metabolism gene	RPL32	TOMM7	0.828693675	3.12E-140
PRAD	Cell metabolism gene	RPL32	NME2	0.839899323	1.46E-147
PRAD	Cell metabolism gene	RPL32	TIMM9	0.860417675	1.43E-162
PRAD	Cell metabolism gene	RPL32	SNRPD2	0.874494533	2.48E-174
PRAD	Cell metabolism gene	RPL32	FAU	0.887060065	4.26E-186
PRAD	CGC	RPL32	NACA	0.87641033	4.83E-176
PRAD	Epifactor	RPL32	FBL	0.88152247	9.52E-181
PRAD	TF	RPL32	ZNF581	0.811809134	3.85E-130
PRAD	TF	RPL32	NME2	0.839899323	1.46E-147
PRAD	TSG	RPL32	GAS5	0.847133981	1.34E-152
PRAD	TSG	RPL32	GNB2L1	0.896154105	1.61E-195
THCA	Cell metabolism gene	RPL32	PFDN5	0.848690807	8.18E-160
THCA	Cell metabolism gene	RPL32	SNRPD2	0.873829861	1.21E-180
THCA	Cell metabolism gene	RPL32	FAU	0.894288984	3.30E-201
THCA	CGC	RPL32	NACA	0.803773531	1.16E-130
THCA	Epifactor	RPL32	FBL	0.83061228	4.74E-147
THCA	IUPHAR	RPL32	CSNK2B	0.811404375	4.73E-135
THCA	TSG	RPL32	GNB2L1	0.879670873	3.97E-186
THYM	Cell metabolism gene	RPL32	SEC61G	0.800451596	1.91E-28
THYM	Cell metabolism gene	RPL32	PSME1	0.805021731	5.52E-29
THYM	Cell metabolism gene	RPL32	TOMM22	0.806107709	4.09E-29
THYM	Cell metabolism gene	RPL32	UROD	0.806803956	3.37E-29
THYM	Cell metabolism gene	RPL32	EXOSC4	0.807463756	2.80E-29
THYM	Cell metabolism gene	RPL32	APOA1	0.80748173	2.79E-29
THYM	Cell metabolism gene	RPL32	IDH3G	0.807643019	2.66E-29
THYM	Cell metabolism gene	RPL32	PGP	0.807859406	2.51E-29
THYM	Cell metabolism gene	RPL32	POLD2	0.809086239	1.78E-29
THYM	Cell metabolism gene	RPL32	LSM5	0.812870854	6.03E-30
THYM	Cell metabolism gene	RPL32	PSMB10	0.814416619	3.85E-30
THYM	Cell metabolism gene	RPL32	DGUOK	0.816582366	2.04E-30
THYM	Cell metabolism gene	RPL32	DPM3	0.817870284	1.39E-30
THYM	Cell metabolism gene	RPL32	ITPA	0.819755649	7.92E-31
THYM	Cell metabolism gene	RPL32	POLR2I	0.820840598	5.70E-31
THYM	Cell metabolism gene	RPL32	LSM3	0.82149446	4.68E-31
THYM	Cell metabolism gene	RPL32	LSM4	0.823442269	2.58E-31
THYM	Cell metabolism gene	RPL32	GUK1	0.82387216	2.26E-31
THYM	Cell metabolism gene	RPL32	SNRPD3	0.825171028	1.51E-31
THYM	Cell metabolism gene	RPL32	PHKG2	0.830209549	3.06E-32
THYM	Cell metabolism gene	RPL32	PSMB1	0.830623397	2.68E-32
THYM	Cell metabolism gene	RPL32	POLD4	0.830861798	2.48E-32
THYM	Cell metabolism gene	RPL32	POLR2H	0.832693943	1.37E-32
THYM	Cell metabolism gene	RPL32	DPM2	0.833223249	1.15E-32
THYM	Cell metabolism gene	RPL32	FPGS	0.833265735	1.13E-32
THYM	Cell metabolism gene	RPL32	EBP	0.833666232	9.93E-33
THYM	Cell metabolism gene	RPL32	POLR2J	0.836999059	3.27E-33
THYM	Cell metabolism gene	RPL32	TIMM50	0.839196151	1.55E-33
THYM	Cell metabolism gene	RPL32	SMPD2	0.843833263	3.11E-34
THYM	Cell metabolism gene	RPL32	MVD	0.847847033	7.39E-35
THYM	Cell metabolism gene	RPL32	POLR2F	0.850313323	2.99E-35
THYM	Cell metabolism gene	RPL32	TIMM13	0.853115421	1.05E-35
THYM	Cell metabolism gene	RPL32	ACOT8	0.857910183	1.67E-36
THYM	Cell metabolism gene	RPL32	MTMR14	0.858293812	1.43E-36
THYM	Cell metabolism gene	RPL32	LSM2	0.860586203	5.79E-37
THYM	Cell metabolism gene	RPL32	PSMD13	0.860809042	5.30E-37
THYM	Cell metabolism gene	RPL32	APRT	0.861399204	4.18E-37
THYM	Cell metabolism gene	RPL32	PSMB7	0.863932032	1.50E-37
THYM	Cell metabolism gene	RPL32	PSMB3	0.865794422	6.93E-38
THYM	Cell metabolism gene	RPL32	PSMC3	0.868004175	2.74E-38
THYM	Cell metabolism gene	RPL32	PGLS	0.871410599	6.35E-39
THYM	Cell metabolism gene	RPL32	SLC27A5	0.881338365	6.95E-41
THYM	Cell metabolism gene	RPL32	SSR2	0.882937355	3.23E-41
THYM	Cell metabolism gene	RPL32	TIMM8B	0.890616955	6.98E-43
THYM	Cell metabolism gene	RPL32	PFDN5	0.907807519	4.14E-47
THYM	Cell metabolism gene	RPL32	SNRPD2	0.911588458	3.76E-48
THYM	Cell metabolism gene	RPL32	FAU	0.956348826	5.85E-66
THYM	CGC	RPL32	MGMT	0.813989382	4.36E-30
THYM	CGC	RPL32	RBM10	0.840356554	1.04E-33
THYM	CGC	RPL32	SDHAF2	0.845217334	1.90E-34
THYM	CGC	RPL32	TFPT	0.854746096	5.66E-36
THYM	Epifactor	RPL32	RRP8	0.800788527	1.75E-28
THYM	Epifactor	RPL32	EXOSC4	0.807463756	2.80E-29
THYM	Epifactor	RPL32	CXXC1	0.815977373	2.44E-30
THYM	Epifactor	RPL32	TADA3	0.818713491	1.08E-30
THYM	Epifactor	RPL32	MBD3	0.819054274	9.77E-31
THYM	Epifactor	RPL32	NOC2L	0.827622471	6.98E-32
THYM	Epifactor	RPL32	RUVBL2	0.837036512	3.23E-33
THYM	Epifactor	RPL32	DMAP1	0.838387866	2.05E-33
THYM	Epifactor	RPL32	PRPF31	0.842755398	4.54E-34
THYM	Epifactor	RPL32	PPP4C	0.843150611	3.95E-34
THYM	Epifactor	RPL32	TFPT	0.854746096	5.66E-36
THYM	Epifactor	RPL32	C17orf49	0.860496305	6.00E-37
THYM	Epifactor	RPL32	CCDC101	0.86218043	3.05E-37
THYM	Epifactor	RPL32	INO80E	0.863095919	2.11E-37
THYM	Epifactor	RPL32	ZNHIT1	0.865267038	8.63E-38
THYM	Epifactor	RPL32	SIRT6	0.866719013	4.71E-38
THYM	Epifactor	RPL32	SS18L2	0.874181655	1.87E-39
THYM	Epifactor	RPL32	FBL	0.883644019	2.30E-41
THYM	Epifactor	RPL32	BRMS1	0.895347589	5.69E-44
THYM	Epifactor	RPL32	TAF10	0.917565466	6.76E-50
THYM	IUPHAR	RPL32	MMP24	0.807883954	2.49E-29
THYM	IUPHAR	RPL32	PPIA	0.80877992	1.94E-29
THYM	IUPHAR	RPL32	CSNK2B	0.81058365	1.16E-29
THYM	IUPHAR	RPL32	TWF2	0.813336653	5.27E-30
THYM	IUPHAR	RPL32	SLC25A38	0.819745352	7.94E-31
THYM	IUPHAR	RPL32	PHKG2	0.830209549	3.06E-32
THYM	IUPHAR	RPL32	PSMB1	0.830623397	2.68E-32
THYM	IUPHAR	RPL32	SMPD2	0.843833263	3.11E-34
THYM	IUPHAR	RPL32	MVD	0.847847033	7.39E-35
THYM	IUPHAR	RPL32	SIRT6	0.866719013	4.71E-38
THYM	IUPHAR	RPL32	SLC27A5	0.881338365	6.95E-41
THYM	Kinase	RPL32	PHKG2	0.830209549	3.06E-32
THYM	TF	RPL32	ZNF691	0.80023647	2.03E-28
THYM	TF	RPL32	THAP7	0.800824677	1.73E-28
THYM	TF	RPL32	AKAP8L	0.810762966	1.10E-29
THYM	TF	RPL32	IRF3	0.813292921	5.33E-30
THYM	TF	RPL32	CXXC1	0.815977373	2.44E-30
THYM	TF	RPL32	MBD3	0.819054274	9.77E-31
THYM	TF	RPL32	ZNF787	0.822229061	3.74E-31
THYM	TF	RPL32	RBCK1	0.823635337	2.43E-31
THYM	TF	RPL32	ETV2	0.825153037	1.52E-31
THYM	TF	RPL32	ZNF688	0.82655553	9.78E-32
THYM	TF	RPL32	DRAP1	0.826892348	8.79E-32
THYM	TF	RPL32	ZNF444	0.8378467	2.46E-33
THYM	TF	RPL32	THAP3	0.841228825	7.72E-34
THYM	TF	RPL32	ZNF428	0.843491469	3.50E-34
THYM	TF	RPL32	THYN1	0.854240014	6.87E-36
THYM	TSG	RPL32	GABARAP	0.810037109	1.36E-29
THYM	TSG	RPL32	IRF3	0.813292921	5.33E-30
THYM	TSG	RPL32	PLEKHO1	0.815927512	2.47E-30
THYM	TSG	RPL32	HTRA2	0.817547273	1.53E-30
THYM	TSG	RPL32	PARK7	0.818350107	1.21E-30
THYM	TSG	RPL32	PFN1	0.823280681	2.71E-31
THYM	TSG	RPL32	GADD45GIP1	0.846503084	1.20E-34
THYM	TSG	RPL32	AIP	0.862840337	2.34E-37
THYM	TSG	RPL32	NPRL2	0.863865855	1.54E-37
THYM	TSG	RPL32	TSSC4	0.863988684	1.46E-37
THYM	TSG	RPL32	SIRT6	0.866719013	4.71E-38
THYM	TSG	RPL32	BRMS1	0.895347589	5.69E-44
THYM	TSG	RPL32	GLTSCR2	0.899094343	7.15E-45
THYM	TSG	RPL32	GNB2L1	0.917957491	5.14E-50
UCEC	Cell metabolism gene	RPL32	FAU	0.800067258	4.86E-46
UCEC	Cell metabolism gene	RPL32	PFDN5	0.825943818	2.00E-51
UCS	Cell metabolism gene	RPL32	SEC61G	0.800451596	1.91E-28
UCS	Cell metabolism gene	RPL32	PSME1	0.805021731	5.52E-29
UCS	Cell metabolism gene	RPL32	TOMM22	0.806107709	4.09E-29
UCS	Cell metabolism gene	RPL32	UROD	0.806803956	3.37E-29
UCS	Cell metabolism gene	RPL32	EXOSC4	0.807463756	2.80E-29
UCS	Cell metabolism gene	RPL32	APOA1	0.80748173	2.79E-29
UCS	Cell metabolism gene	RPL32	IDH3G	0.807643019	2.66E-29
UCS	Cell metabolism gene	RPL32	PGP	0.807859406	2.51E-29
UCS	Cell metabolism gene	RPL32	POLD2	0.809086239	1.78E-29
UCS	Cell metabolism gene	RPL32	LSM5	0.812870854	6.03E-30
UCS	Cell metabolism gene	RPL32	PSMB10	0.814416619	3.85E-30
UCS	Cell metabolism gene	RPL32	DGUOK	0.816582366	2.04E-30
UCS	Cell metabolism gene	RPL32	DPM3	0.817870284	1.39E-30
UCS	Cell metabolism gene	RPL32	ITPA	0.819755649	7.92E-31
UCS	Cell metabolism gene	RPL32	POLR2I	0.820840598	5.70E-31
UCS	Cell metabolism gene	RPL32	LSM3	0.82149446	4.68E-31
UCS	Cell metabolism gene	RPL32	LSM4	0.823442269	2.58E-31
UCS	Cell metabolism gene	RPL32	GUK1	0.82387216	2.26E-31
UCS	Cell metabolism gene	RPL32	SNRPD3	0.825171028	1.51E-31
UCS	Cell metabolism gene	RPL32	PHKG2	0.830209549	3.06E-32
UCS	Cell metabolism gene	RPL32	PSMB1	0.830623397	2.68E-32
UCS	Cell metabolism gene	RPL32	POLD4	0.830861798	2.48E-32
UCS	Cell metabolism gene	RPL32	POLR2H	0.832693943	1.37E-32
UCS	Cell metabolism gene	RPL32	DPM2	0.833223249	1.15E-32
UCS	Cell metabolism gene	RPL32	FPGS	0.833265735	1.13E-32
UCS	Cell metabolism gene	RPL32	EBP	0.833666232	9.93E-33
UCS	Cell metabolism gene	RPL32	POLR2J	0.836999059	3.27E-33
UCS	Cell metabolism gene	RPL32	TIMM50	0.839196151	1.55E-33
UCS	Cell metabolism gene	RPL32	SMPD2	0.843833263	3.11E-34
UCS	Cell metabolism gene	RPL32	MVD	0.847847033	7.39E-35
UCS	Cell metabolism gene	RPL32	POLR2F	0.850313323	2.99E-35
UCS	Cell metabolism gene	RPL32	TIMM13	0.853115421	1.05E-35
UCS	Cell metabolism gene	RPL32	ACOT8	0.857910183	1.67E-36
UCS	Cell metabolism gene	RPL32	MTMR14	0.858293812	1.43E-36
UCS	Cell metabolism gene	RPL32	LSM2	0.860586203	5.79E-37
UCS	Cell metabolism gene	RPL32	PSMD13	0.860809042	5.30E-37
UCS	Cell metabolism gene	RPL32	APRT	0.861399204	4.18E-37
UCS	Cell metabolism gene	RPL32	PSMB7	0.863932032	1.50E-37
UCS	Cell metabolism gene	RPL32	PSMB3	0.865794422	6.93E-38
UCS	Cell metabolism gene	RPL32	PSMC3	0.868004175	2.74E-38
UCS	Cell metabolism gene	RPL32	PGLS	0.871410599	6.35E-39
UCS	Cell metabolism gene	RPL32	SLC27A5	0.881338365	6.95E-41
UCS	Cell metabolism gene	RPL32	SSR2	0.882937355	3.23E-41
UCS	Cell metabolism gene	RPL32	TIMM8B	0.890616955	6.98E-43
UCS	Cell metabolism gene	RPL32	PFDN5	0.907807519	4.14E-47
UCS	Cell metabolism gene	RPL32	SNRPD2	0.911588458	3.76E-48
UCS	Cell metabolism gene	RPL32	FAU	0.956348826	5.85E-66
UCS	CGC	RPL32	MGMT	0.813989382	4.36E-30
UCS	CGC	RPL32	RBM10	0.840356554	1.04E-33
UCS	CGC	RPL32	SDHAF2	0.845217334	1.90E-34
UCS	CGC	RPL32	TFPT	0.854746096	5.66E-36
UCS	Epifactor	RPL32	RRP8	0.800788527	1.75E-28
UCS	Epifactor	RPL32	EXOSC4	0.807463756	2.80E-29
UCS	Epifactor	RPL32	CXXC1	0.815977373	2.44E-30
UCS	Epifactor	RPL32	TADA3	0.818713491	1.08E-30
UCS	Epifactor	RPL32	MBD3	0.819054274	9.77E-31
UCS	Epifactor	RPL32	NOC2L	0.827622471	6.98E-32
UCS	Epifactor	RPL32	RUVBL2	0.837036512	3.23E-33
UCS	Epifactor	RPL32	DMAP1	0.838387866	2.05E-33
UCS	Epifactor	RPL32	PRPF31	0.842755398	4.54E-34
UCS	Epifactor	RPL32	PPP4C	0.843150611	3.95E-34
UCS	Epifactor	RPL32	TFPT	0.854746096	5.66E-36
UCS	Epifactor	RPL32	C17orf49	0.860496305	6.00E-37
UCS	Epifactor	RPL32	CCDC101	0.86218043	3.05E-37
UCS	Epifactor	RPL32	INO80E	0.863095919	2.11E-37
UCS	Epifactor	RPL32	ZNHIT1	0.865267038	8.63E-38
UCS	Epifactor	RPL32	SIRT6	0.866719013	4.71E-38
UCS	Epifactor	RPL32	SS18L2	0.874181655	1.87E-39
UCS	Epifactor	RPL32	FBL	0.883644019	2.30E-41
UCS	Epifactor	RPL32	BRMS1	0.895347589	5.69E-44
UCS	Epifactor	RPL32	TAF10	0.917565466	6.76E-50
UCS	IUPHAR	RPL32	MMP24	0.807883954	2.49E-29
UCS	IUPHAR	RPL32	PPIA	0.80877992	1.94E-29
UCS	IUPHAR	RPL32	CSNK2B	0.81058365	1.16E-29
UCS	IUPHAR	RPL32	TWF2	0.813336653	5.27E-30
UCS	IUPHAR	RPL32	SLC25A38	0.819745352	7.94E-31
UCS	IUPHAR	RPL32	PHKG2	0.830209549	3.06E-32
UCS	IUPHAR	RPL32	PSMB1	0.830623397	2.68E-32
UCS	IUPHAR	RPL32	SMPD2	0.843833263	3.11E-34
UCS	IUPHAR	RPL32	MVD	0.847847033	7.39E-35
UCS	IUPHAR	RPL32	SIRT6	0.866719013	4.71E-38
UCS	IUPHAR	RPL32	SLC27A5	0.881338365	6.95E-41
UCS	Kinase	RPL32	PHKG2	0.830209549	3.06E-32
UCS	TF	RPL32	ZNF691	0.80023647	2.03E-28
UCS	TF	RPL32	THAP7	0.800824677	1.73E-28
UCS	TF	RPL32	AKAP8L	0.810762966	1.10E-29
UCS	TF	RPL32	IRF3	0.813292921	5.33E-30
UCS	TF	RPL32	CXXC1	0.815977373	2.44E-30
UCS	TF	RPL32	MBD3	0.819054274	9.77E-31
UCS	TF	RPL32	ZNF787	0.822229061	3.74E-31
UCS	TF	RPL32	RBCK1	0.823635337	2.43E-31
UCS	TF	RPL32	ETV2	0.825153037	1.52E-31
UCS	TF	RPL32	ZNF688	0.82655553	9.78E-32
UCS	TF	RPL32	DRAP1	0.826892348	8.79E-32
UCS	TF	RPL32	ZNF444	0.8378467	2.46E-33
UCS	TF	RPL32	THAP3	0.841228825	7.72E-34
UCS	TF	RPL32	ZNF428	0.843491469	3.50E-34
UCS	TF	RPL32	THYN1	0.854240014	6.87E-36
UCS	TSG	RPL32	GABARAP	0.810037109	1.36E-29
UCS	TSG	RPL32	IRF3	0.813292921	5.33E-30
UCS	TSG	RPL32	PLEKHO1	0.815927512	2.47E-30
UCS	TSG	RPL32	HTRA2	0.817547273	1.53E-30
UCS	TSG	RPL32	PARK7	0.818350107	1.21E-30
UCS	TSG	RPL32	PFN1	0.823280681	2.71E-31
UCS	TSG	RPL32	GADD45GIP1	0.846503084	1.20E-34
UCS	TSG	RPL32	AIP	0.862840337	2.34E-37
UCS	TSG	RPL32	NPRL2	0.863865855	1.54E-37
UCS	TSG	RPL32	TSSC4	0.863988684	1.46E-37
UCS	TSG	RPL32	SIRT6	0.866719013	4.71E-38
UCS	TSG	RPL32	BRMS1	0.895347589	5.69E-44
UCS	TSG	RPL32	GLTSCR2	0.899094343	7.15E-45
UCS	TSG	RPL32	GNB2L1	0.917957491	5.14E-50
UVM	Cell metabolism gene	RPL32	TOMM7	0.805453827	2.11E-19
UVM	Cell metabolism gene	RPL32	POLR1D	0.807703336	1.40E-19
UVM	Cell metabolism gene	RPL32	POLR2H	0.815727325	3.13E-20
UVM	Cell metabolism gene	RPL32	FAU	0.831868604	1.22E-21
UVM	Cell metabolism gene	RPL32	LSM3	0.833245999	9.08E-22
UVM	Cell metabolism gene	RPL32	SLC27A5	0.840083128	2.03E-22
UVM	Cell metabolism gene	RPL32	LTA4H	0.840999857	1.66E-22
UVM	Epifactor	RPL32	FBL	0.876875112	1.58E-26
UVM	IUPHAR	RPL32	SLC25A26	0.832062441	1.17E-21
UVM	IUPHAR	RPL32	SLC27A5	0.840083128	2.03E-22
UVM	IUPHAR	RPL32	LTA4H	0.840999857	1.66E-22
UVM	TF	RPL32	ZNF581	0.827296816	3.16E-21
UVM	TF	RPL32	REXO4	0.831738173	1.25E-21
UVM	TSG	RPL32	GNB2L1	0.813900029	4.44E-20
UVM	TSG	RPL32	GLTSCR2	0.829545985	1.98E-21
UVM	TSG	RPL32	ST13	0.831672224	1.27E-21

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL32	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL32	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL32	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL32	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL32	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL32	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL32	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL32	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL32	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL32	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL32	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL32	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL32	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL32	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL32	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL32	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL32	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL32	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL32	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL32	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL32	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL32	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL32	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL32	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL32	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL32	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL32	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL32	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL32

PSTPIP1, HDGF, CDK2, CUL1, COPS5, CAND1, RPL10A, RPL12, RPL14, RPL15, RPL18, RPL19, RPL21, RPL5, RPL7, RPL8, RPL9, RPS23, RPS26, RPS2, RPS3, RPS4X, RPS6, RPL23A, RPL7A, RPS8, RPL4, RPSA, RPS20, RPL17, RPS15A, RPS16, RPL23, RPS3A, RPL18A, RPL3, RPL29, ILF3, TUFM, HSP90AB1, CDH2, RPLP0P6, NACA2, MTHFD1, HSP90AA1, CALU, NENF, UBL4A, PAN2, FBXO6, TARDBP, rev, BRCA1, RNF2, ABCE1, DHX8, THAP7, ZC3H3, RPL27A, RPL11, RPL13A, RPL24, RPL27, RPL34, RPL6, RPLP0, RPS11, RPS15, RPS9, SLC1A2, RPL35A, RPL37A, RPL39, RPS13, UBA52, HIST1H3E, HNRNPU, KIF11, NPM1, RPL10, NOP56, Eif3a, Eif3e, Rpl35, Srp72, Rrbp1, MCM2, Ksr1, DUSP11, DUSP5, MAK16, CNBP, ZNF512, RPL30, RBM34, KIAA0020, MAGEB10, RRP8, RPS14, RPL28, WDR46, RBM4, MECP2, ZC3HAV1, RRS1, ZBTB48, GPATCH4, PRPF3, PRPF4, ALYREF, FAU, LSM4, LSM8, RPL26L1, SART3, PPIH, CYLD, COX15, PDHA1, FOXA1, TRIM25, CFTR, CTNNBL1, PTTG1, RBBP8, RPL35, SNAPC1, ZNF598, HBP1, GSK3A, KRAS, PRPF8, AAR2, PIH1D1, EFTUD2, RNF4, RIOK1, MEPCE, LARP7, AGR2, RECQL4, RPS6KB2, FBL, TGOLN2, CANX, EZR, HIST1H3A, AURKAIP1, GRWD1, RC3H1, RC3H2, ACTC1, PHB, RBX1, NR2C2, PPP1CC, CTCF, VRK1, HIST1H4A, SNRNP70, PTP4A3, PTPN6, ITFG1, HMGB1, STAU1, WWP2, CMTR1, PLEKHA4, WHSC1, FANCD2, PTEN, HCVgp1, ZC3H18, GRB7, MAP3K14, RAB5A, SH3GL3, SNIP1, M, nsp4, nsp5, nsp6, ORF7b, ESR1, NEK4, CIT, ANLN, AURKB, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, GRSF1, MKI67, INS, Rnf183, BRD4, Apc2, RBM39, FBP1, RIN3, DNAJC2, PARK2, UFL1, DDRGK1, FZR1, PAGE4, MAP4K1, MAP4K2, MAP4K4, MAP4K5, MINK1, NAA40, RSL1D1, LYAR, CCDC140, SRSF6, MRPL13, PRKRA, REXO4, SRSF5, CCDC137, RBMX2, IL17B, RPL26, MYBBP1A, ZNF48, H1FOO, ITGAD, C1QBP, DDX21, NOP2, MRPL24, RPL22, NSA2, FGFBP1, ADARB1, MRPL3, RPL36, SRSF1, SRPK2, RPL13, ZC3H10, NPM3, HBB, HBA2, HBD, BTF3, RCHY1, KLF16,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL32	ESCA	chr3	12877607	12877607	C	T	Missense_Mutation	p.E132K	3
RPL32	ESCA	chr3	12877607	12877607	C	T	Missense_Mutation		2
RPL32	LAML	chr3	12855994	12855994	C	A	Missense_Mutation	p.R44S	2
RPL32	UCEC	chr3	12880925	12880925	C	T	Silent	p.K67	2
RPL32	ESCA	chr3	12877613	12877613	G	A	Missense_Mutation	p.R130C	2
RPL32	BLCA	chr3	12877707	12877707	C	T	Silent	p.E98E	2
RPL32	PAAD	chr3	12881074	12881074	C	T	Missense_Mutation		1
RPL32	COAD	chr3	12881730	12881730	C	T	Missense_Mutation	p.A3T	1
RPL32	HNSC	chr3	12880876	12880876	C	G	Missense_Mutation		1
RPL32	PAAD	chr3	12877678	12877678	C	T	Missense_Mutation	p.R108H	1
RPL32	DLBC	chr3	12877704	12877704	G	A	Silent	p.I99I	1
RPL32	HNSC	chr3	12881680	12881680	C	T	Silent		1
RPL32	SKCM	chr3	12877690	12877690	G	A	Missense_Mutation	p.S104F	1
RPL32	HNSC	chr3	12880876	12880876	C	G	Missense_Mutation	p.E84Q	1
RPL32	SKCM	chr3	12881705	12881705	T	C	Missense_Mutation	p.K11R	1
RPL32	ESCA	chr3	12877710	12877710	G	T	Silent	p.A97	1
RPL32	HNSC	chr3	12881680	12881680	C	T	Silent	p.K19K	1
RPL32	BLCA	chr3	12881069	12881069	G	A	Silent		1
RPL32	UCEC	chr3	12880929	12880930	-	T	Frame_Shift_Ins	p.T66fs	1
RPL32	BLCA	chr3	12881719	12881719	G	T	Silent		1
RPL32	LGG	chr3	12881651	12881651	A	G	Missense_Mutation	p.V29A	1
RPL32	BLCA	chr3	12877707	12877707	C	T	Silent		1
RPL32	ESCA	chr3	12877710	12877710	G	T	Silent	p.A97A	1
RPL32	LGG	chr3	12877613	12877613	G	A	Missense_Mutation		1
RPL32	BLCA	chr3	12881080	12881080	C	T	Missense_Mutation		1
RPL32	GBM	chr3	12880946	12880946	A	G	Silent	p.Y60Y	1
RPL32	LIHC	chr3	12881047	12881047	C	T	Missense_Mutation		1
RPL32	BLCA	chr3	12881650	12881650	G	T	Silent		1
RPL32	GBM	chr3	12881707	12881707	G	A	Silent	p.P10P	1
RPL32	LUSC	chr3	12880933	12880933	T	C	Missense_Mutation	p.K65E	1
RPL32	BLCA	chr3	12881704	12881704	C	G	Missense_Mutation		1
RPL32	GBM	chr3	12880946	12880946	A	G	Nonsense_Mutation		1
RPL32	OV	chr3	12880849	12880849	T	A	Nonsense_Mutation	p.K93*	1
RPL32	GBM	chr3	12877709	12877709	C	T	Missense_Mutation		1

Copy number variation (CNV) of RPL32
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL32
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
95495	N/A	EC502300	ATG4A	chrX	107367668	-	RPL32	chr3	12881706	-
95495	N/A	EC574185	MTHFD1L	chr6	151420740	+	RPL32	chr3	12881742	-
95495	N/A	K03002	MTHFD1L	chr6	151420613	-	RPL32	chr3	12881713	-
95495	N/A	BI491561	MTUS1	chr8	17621897	-	RPL32	chr3	12877548	+
95495	N/A	AA837061	PARK2	chr6	161864021	-	RPL32	chr3	12877548	+
95495	CESC	TCGA-DS-A3LQ-01A	RAF1	chr3	12705312	-	RPL32	chr3	12877722	-
85597	PRAD	TCGA-EJ-5511-01A	RPL32	chr3	12882993	-	ATP5G2	chr12	54070182	-
79571	N/A	AI343531	RPL32	chr3	12877654	+	CA12	chr15	63617526	+
85579	N/A	BG577153	RPL32	chr3	12877548	-	GLIS3	chr9	3918751	+
76519	N/A	AA079473	RPL32	chr3	12880848	-	LINC00623	chr1	144341481	-
76519	OV	TCGA-59-2355	RPL32	chr3	12881640	-	NEXN	chr1	78383809	+
92542	N/A	EC567799	RPL32	chr3	12877549	-	PCCA	chr13	100861891	-
103051	N/A	W48816	RPL32	chr3	12877645	+	PPP2R1A	chr19	52719874	-
76519	N/A	AA505147	RPL32	chr3	12877644	+	SERPINA9	chr14	94935855	+
101365	N/A	AW023409	RPL32	chr3	12877546	-	SFPQ	chr1	35656039	+
85986	N/A	BI856872	RPL32	chr3	12877546	-	SHB	chr9	37979620	+
81106	OV	TCGA-10-0934	RPL32	chr3	12880847	-	WNT7A	chr3	13896300	-
81106	OV	TCGA-10-0934-01A	RPL32	chr3	12880848	-	WNT7A	chr3	13896300	-
96441	N/A	BM016477	RPL32	chr3	12877546	-	ZFAND3	chr6	37822764	-
95495	N/A	BI493216	SFPQ	chr1	35656039	-	RPL32	chr3	12877546	+
95495	LUAD	TCGA-L9-A8F4	SLC6A6	chr3	14499590	+	RPL32	chr3	12883123	-
95495	N/A	BI492992	TBC1D3P1-DHX40P1	chr17	58051102	+	RPL32	chr3	12877548	+
95495	N/A	N67941	TBC1D3P1-DHX40P1	chr17	58051119	+	RPL32	chr3	12877546	+
95496	N/A	CS190105	TVP23C-CDRT4	chr17	15414841	+	RPL32	chr3	12882407	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
MESO	RPL32	0.0112011106715607	0.3
SARC	RPL32	0.0283604590527526	0.74
STAD	RPL32	0.048866100998889	1
KIRC	RPL32	9.94409534976917e-06	0.00028

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL32	0.0149816637323413	0.49
GBM	RPL32	0.0493206968891837	1
PAAD	RPL32	0.0363624086769137	1
BLCA	RPL32	0.0153553177288543	0.49

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source