Home

Download

Statistics

Examples

Help

Contact

	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL35A (NCBI Gene ID:6165)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL35A
	Gene ID: 6165
	Gene Symbol	RPL35A
	Gene ID	6165
	Gene Name	ribosomal protein L35a
	Synonyms	DBA5\|L35A\|eL33
	Cytomap	3q29
	Type of Gene	protein-coding
	Description	60S ribosomal protein L35acell growth-inhibiting gene 33 proteinlarge ribosomal subunit protein eL33
	Modification date	20200313
	UniProtAcc	P18077

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL35A	>1119.25

Top

Translation Studies in PubMed

We searched PubMed using 'RPL35A[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL35A	.	.

Top

Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000448864	197678029	197678182	In-frame
ENST00000464167	197678029	197678182	In-frame
ENST00000448864	197680873	197681018	Frame-shift
ENST00000464167	197680873	197681018	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000448864	197678029	197678182	566	150	302	110	4	54
ENST00000464167	197678029	197678182	1454	279	431	110	4	54

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P18077	4	54	1	110	Chain	ID=PRO_0000192796;Note=60S ribosomal protein L35a
P18077	4	54	1	110	Chain	ID=PRO_0000192796;Note=60S ribosomal protein L35a
P18077	4	54	8	8	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19608861;Dbxref=PMID:19608861
P18077	4	54	8	8	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19608861;Dbxref=PMID:19608861
P18077	4	54	27	27	Natural variant	ID=VAR_055446;Note=In DBA5. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18535205;Dbxref=PMID:18535205
P18077	4	54	27	27	Natural variant	ID=VAR_055446;Note=In DBA5. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18535205;Dbxref=PMID:18535205
P18077	4	54	33	33	Natural variant	ID=VAR_055447;Note=In DBA5%3B may result in aberrant splicing. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18535205;Dbxref=dbSNP:rs116840808,PMID:18535205
P18077	4	54	33	33	Natural variant	ID=VAR_055447;Note=In DBA5%3B may result in aberrant splicing. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18535205;Dbxref=dbSNP:rs116840808,PMID:18535205

Top

Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRC	RPL35A	-2.33246813425378	3.7449081319937e-09

Top

Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
STAD	RPL35A	-0.053885839	0.022268706

Top

Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL35A (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	RPL35A	POLR2H	0.812582517	1.22E-11
CHOL	Cell metabolism gene	RPL35A	SNRPD2	0.820339773	5.35E-12
DLBC	Cell metabolism gene	RPL35A	TIMM9	0.821611723	8.34E-13
DLBC	Cell metabolism gene	RPL35A	FAU	0.831118105	2.64E-13
DLBC	TSG	RPL35A	GNB2L1	0.837751466	1.13E-13
GBM	Cell metabolism gene	RPL35A	SSR2	0.81537252	3.32E-42
GBM	Cell metabolism gene	RPL35A	PSMA5	0.817325532	1.47E-42
GBM	Cell metabolism gene	RPL35A	SSR4	0.819508598	5.84E-43
GBM	Cell metabolism gene	RPL35A	PIGC	0.828885072	9.59E-45
GBM	TSG	RPL35A	GAS5	0.846269049	2.33E-48
LGG	Cell metabolism gene	RPL35A	FAU	0.846361926	1.43E-146
LGG	CGC	RPL35A	NACA	0.812711133	5.92E-126
LGG	TSG	RPL35A	GNB2L1	0.810817886	6.40E-125
LIHC	Cell metabolism gene	RPL35A	SNRPD2	0.803190095	9.50E-97
LIHC	Cell metabolism gene	RPL35A	POLR2H	0.849785537	3.86E-119
LIHC	Epifactor	RPL35A	FBL	0.815871789	3.33E-102
PCPG	Cell metabolism gene	RPL35A	POLR2H	0.808390733	1.91E-44
PRAD	Cell metabolism gene	RPL35A	POLR2H	0.804906205	2.64E-126
PRAD	Cell metabolism gene	RPL35A	FAU	0.81613896	1.25E-132
PRAD	Cell metabolism gene	RPL35A	SNRPD2	0.833457016	2.79E-143
PRAD	Cell metabolism gene	RPL35A	TIMM9	0.840416839	6.50E-148
PRAD	CGC	RPL35A	NACA	0.829884164	5.51E-141
PRAD	Epifactor	RPL35A	FBL	0.821244834	1.19E-135
PRAD	TSG	RPL35A	GNB2L1	0.831611068	4.35E-142
THCA	Cell metabolism gene	RPL35A	FAU	0.808024891	4.41E-133
THCA	Cell metabolism gene	RPL35A	PFDN5	0.826186031	3.72E-144
THCA	Cell metabolism gene	RPL35A	SNRPD2	0.827190683	8.33E-145
THYM	Cell metabolism gene	RPL35A	DPM2	0.803910095	7.49E-29
THYM	Cell metabolism gene	RPL35A	SNRPD3	0.80712864	3.08E-29
THYM	Cell metabolism gene	RPL35A	ITPA	0.812778809	6.19E-30
THYM	Cell metabolism gene	RPL35A	SNRPE	0.813434791	5.12E-30
THYM	Cell metabolism gene	RPL35A	PSMB3	0.813722819	4.71E-30
THYM	Cell metabolism gene	RPL35A	PSME1	0.815436	2.86E-30
THYM	Cell metabolism gene	RPL35A	SEC61G	0.817352121	1.62E-30
THYM	Cell metabolism gene	RPL35A	OAZ1	0.818111134	1.30E-30
THYM	Cell metabolism gene	RPL35A	ACOT8	0.818412242	1.18E-30
THYM	Cell metabolism gene	RPL35A	PSMB1	0.819694744	8.06E-31
THYM	Cell metabolism gene	RPL35A	SMPD2	0.825525586	1.35E-31
THYM	Cell metabolism gene	RPL35A	TALDO1	0.829611496	3.71E-32
THYM	Cell metabolism gene	RPL35A	PSMC3	0.830506984	2.78E-32
THYM	Cell metabolism gene	RPL35A	PSMD13	0.836746424	3.56E-33
THYM	Cell metabolism gene	RPL35A	PSMB7	0.844893258	2.13E-34
THYM	Cell metabolism gene	RPL35A	LSM2	0.854656753	5.86E-36
THYM	Cell metabolism gene	RPL35A	POLR2H	0.859212633	9.99E-37
THYM	Cell metabolism gene	RPL35A	TIMM13	0.860255726	6.61E-37
THYM	Cell metabolism gene	RPL35A	TIMM8B	0.860532069	5.92E-37
THYM	Cell metabolism gene	RPL35A	PFDN5	0.864082237	1.41E-37
THYM	Cell metabolism gene	RPL35A	FAU	0.872586717	3.79E-39
THYM	Cell metabolism gene	RPL35A	SLC27A5	0.883395481	2.59E-41
THYM	Cell metabolism gene	RPL35A	SNRPD2	0.885728276	8.28E-42
THYM	Cell metabolism gene	RPL35A	SSR2	0.902363966	1.10E-45
THYM	CGC	RPL35A	SDHAF2	0.814833959	3.41E-30
THYM	CGC	RPL35A	TFPT	0.816889695	1.86E-30
THYM	Epifactor	RPL35A	PPP4C	0.801668669	1.38E-28
THYM	Epifactor	RPL35A	C17orf49	0.812694033	6.34E-30
THYM	Epifactor	RPL35A	TFPT	0.816889695	1.86E-30
THYM	Epifactor	RPL35A	RRP8	0.820457991	6.40E-31
THYM	Epifactor	RPL35A	SIRT6	0.824693537	1.75E-31
THYM	Epifactor	RPL35A	TAF10	0.824919974	1.63E-31
THYM	Epifactor	RPL35A	BRMS1	0.84031169	1.06E-33
THYM	Epifactor	RPL35A	FBL	0.911258885	4.65E-48
THYM	IUPHAR	RPL35A	MFSD2B	0.818854425	1.04E-30
THYM	IUPHAR	RPL35A	PSMB1	0.819694744	8.06E-31
THYM	IUPHAR	RPL35A	SIRT6	0.824693537	1.75E-31
THYM	IUPHAR	RPL35A	SMPD2	0.825525586	1.35E-31
THYM	IUPHAR	RPL35A	SLC27A5	0.883395481	2.59E-41
THYM	TF	RPL35A	ZNF787	0.800532817	1.87E-28
THYM	TF	RPL35A	REXO4	0.80141892	1.47E-28
THYM	TF	RPL35A	THAP3	0.805616432	4.68E-29
THYM	TF	RPL35A	ZNF581	0.812539212	6.63E-30
THYM	TF	RPL35A	ZNF428	0.822743377	3.19E-31
THYM	TSG	RPL35A	SIRT6	0.824693537	1.75E-31
THYM	TSG	RPL35A	TSSC4	0.836351142	4.07E-33
THYM	TSG	RPL35A	BRMS1	0.84031169	1.06E-33
THYM	TSG	RPL35A	GNB2L1	0.87330774	2.76E-39
UCS	Cell metabolism gene	RPL35A	DPM2	0.803910095	7.49E-29
UCS	Cell metabolism gene	RPL35A	SNRPD3	0.80712864	3.08E-29
UCS	Cell metabolism gene	RPL35A	ITPA	0.812778809	6.19E-30
UCS	Cell metabolism gene	RPL35A	SNRPE	0.813434791	5.12E-30
UCS	Cell metabolism gene	RPL35A	PSMB3	0.813722819	4.71E-30
UCS	Cell metabolism gene	RPL35A	PSME1	0.815436	2.86E-30
UCS	Cell metabolism gene	RPL35A	SEC61G	0.817352121	1.62E-30
UCS	Cell metabolism gene	RPL35A	OAZ1	0.818111134	1.30E-30
UCS	Cell metabolism gene	RPL35A	ACOT8	0.818412242	1.18E-30
UCS	Cell metabolism gene	RPL35A	PSMB1	0.819694744	8.06E-31
UCS	Cell metabolism gene	RPL35A	SMPD2	0.825525586	1.35E-31
UCS	Cell metabolism gene	RPL35A	TALDO1	0.829611496	3.71E-32
UCS	Cell metabolism gene	RPL35A	PSMC3	0.830506984	2.78E-32
UCS	Cell metabolism gene	RPL35A	PSMD13	0.836746424	3.56E-33
UCS	Cell metabolism gene	RPL35A	PSMB7	0.844893258	2.13E-34
UCS	Cell metabolism gene	RPL35A	LSM2	0.854656753	5.86E-36
UCS	Cell metabolism gene	RPL35A	POLR2H	0.859212633	9.99E-37
UCS	Cell metabolism gene	RPL35A	TIMM13	0.860255726	6.61E-37
UCS	Cell metabolism gene	RPL35A	TIMM8B	0.860532069	5.92E-37
UCS	Cell metabolism gene	RPL35A	PFDN5	0.864082237	1.41E-37
UCS	Cell metabolism gene	RPL35A	FAU	0.872586717	3.79E-39
UCS	Cell metabolism gene	RPL35A	SLC27A5	0.883395481	2.59E-41
UCS	Cell metabolism gene	RPL35A	SNRPD2	0.885728276	8.28E-42
UCS	Cell metabolism gene	RPL35A	SSR2	0.902363966	1.10E-45
UCS	CGC	RPL35A	SDHAF2	0.814833959	3.41E-30
UCS	CGC	RPL35A	TFPT	0.816889695	1.86E-30
UCS	Epifactor	RPL35A	PPP4C	0.801668669	1.38E-28
UCS	Epifactor	RPL35A	C17orf49	0.812694033	6.34E-30
UCS	Epifactor	RPL35A	TFPT	0.816889695	1.86E-30
UCS	Epifactor	RPL35A	RRP8	0.820457991	6.40E-31
UCS	Epifactor	RPL35A	SIRT6	0.824693537	1.75E-31
UCS	Epifactor	RPL35A	TAF10	0.824919974	1.63E-31
UCS	Epifactor	RPL35A	BRMS1	0.84031169	1.06E-33
UCS	Epifactor	RPL35A	FBL	0.911258885	4.65E-48
UCS	IUPHAR	RPL35A	MFSD2B	0.818854425	1.04E-30
UCS	IUPHAR	RPL35A	PSMB1	0.819694744	8.06E-31
UCS	IUPHAR	RPL35A	SIRT6	0.824693537	1.75E-31
UCS	IUPHAR	RPL35A	SMPD2	0.825525586	1.35E-31
UCS	IUPHAR	RPL35A	SLC27A5	0.883395481	2.59E-41
UCS	TF	RPL35A	ZNF787	0.800532817	1.87E-28
UCS	TF	RPL35A	REXO4	0.80141892	1.47E-28
UCS	TF	RPL35A	THAP3	0.805616432	4.68E-29
UCS	TF	RPL35A	ZNF581	0.812539212	6.63E-30
UCS	TF	RPL35A	ZNF428	0.822743377	3.19E-31
UCS	TSG	RPL35A	SIRT6	0.824693537	1.75E-31
UCS	TSG	RPL35A	TSSC4	0.836351142	4.07E-33
UCS	TSG	RPL35A	BRMS1	0.84031169	1.06E-33
UCS	TSG	RPL35A	GNB2L1	0.87330774	2.76E-39
UVM	Cell metabolism gene	RPL35A	LTA4H	0.866901463	2.70E-25
UVM	IUPHAR	RPL35A	SLC25A26	0.828166685	2.64E-21
UVM	IUPHAR	RPL35A	LTA4H	0.866901463	2.70E-25
UVM	TSG	RPL35A	ST13	0.837013061	4.02E-22

Top

Protein structure

Protein 3D structure
Visit iCn3D.

Top

Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL35A	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL35A	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL35A	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL35A	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL35A	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL35A	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL35A	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL35A	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL35A	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL35A	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL35A	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL35A	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL35A	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL35A	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL35A	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL35A	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL35A	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL35A	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL35A	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL35A	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL35A	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL35A	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL35A	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL35A	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL35A	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL35A	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL35A	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL35A	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL35A

PSTPIP1, CNBP, SH3GL3, NOP56, RAD21, HDGF, ARRB2, CUL3, CUL4B, CUL1, CAND1, PAN2, IGSF8, ICAM1, rev, ASB2, UBC, ABCE1, HNRNPUL2, RNPS1, RPL10A, RPL12, RPL15, RPL17, MTHFD1, NUMA1, RPL10, RPL11, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22, RPL23, RPL23A, RPL24, RPL27, RPL27A, RPL3, RPL31, RPL32, RPL34, RPL35, RPL36AL, RPL37, RPL4, RPL6, RPL7, RPL7A, RPL8, RPL9, RPLP0, RPLP2, RPS11, RPS12, RPS13, RPS15, RPS16, RPS19, RPS2, RPS20, RPS25, RPS3, RPS4X, RPS8, RPS9, RPSA, UBA52, RPL36, RPL39, RPL5, RPS10, RPS14, RPS15A, RPS18, RPS27, RPS27L, RPS3A, RPS5, RPS6, RTF1, Eif3a, Rrbp1, MCM2, RRS1, RBM34, KIAA0020, PTPN6, NCL, CYLD, COX15, TRIM25, MTF1, CFTR, CBX3, TFDP1, WDR5, TRIM14, HBP1, BMP4, KRAS, TRIP4, API5, ARNT, CTNNB1, HNF1B, MAP2K1, PCBP1, PPIE, AAR2, PIH1D1, EFTUD2, TNIP2, MEPCE, LARP7, HERC2, KCMF1, RNF181, AGR2, RECQL4, DCPS, REST, MYC, METTL14, ACTC1, ZBTB7A, PHB, NR2C2, CTCF, VRK1, HIST1H4A, SNRNP70, PTPN21, ITFG1, BIRC3, STAU1, NFX1, WWP2, Hsp22, SOX2, CMTR1, ARIH2, PLEKHA4, FANCD2, ZC3H18, GRB7, MAP3K14, NCK1, M, nsp13, nsp4, nsp5, nsp6, ORF3a, ORF6, ORF7a, ORF7b, S, ESR1, HTRA2, IMMP2L, NEK4, CIT, ANLN, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, MTERF3, Rnf183, MAFB, Apc2, RBM39, FBP1, LGALS9, BKRF1, DNAJC2, DNAJC17, DNAJC8, HSCB, LIN28A, SETD8, FBXL19, RPL26L1, HIST1H2AI, CPSF3L, RALY, S100A7, S100A8, DDX58, PARK2, UFL1, DDRGK1, TRIM37, USP15, HTRA4, FZR1, PAGE4, UHRF1, CHORDC1, SH3GL1, WDHD1, NAA50, XPNPEP1, CYB5R3, UBE2T, CD3EAP, ARF5, PRKRA, UBLCP1, OXSR1, C12orf57, SRRT, RPRD1B, YY1, RECQL, PPP1R8, EIF4G2, SCML2, RBM33, WDR3, MAVS, PDS5A, NARS, GLS, NSDHL, BRD4, TLN1, SF3A3, RAB5B, FEN1, DUSP3, WDR36, VAMP3, ACAA1, TTLL12, RNF20, CTNNBL1, ETF1, SF1, LZIC, PPP2R5D, SMCHD1, CCDC51, RAB5A, DACH1, MDC1, PHF3, ZC3H11A, DDX46, TOMM34, BLVRB, FAM49B, NDRG1, RAB4A, ATG3, LETM1, GTF2F1, RAP1B, RAP1A, PAPSS1, SF3A1, EFHD1, SAR1B, NDUFB8, UBP1, PTRH2, PKN2, ZMPSTE24, TPP2, HIBCH, SYAP1, SRP68, MLLT4, HDLBP, BRD3, DBNL, COQ9, CKAP5, KIF2A, PIN1, PRPF38B, WIBG, LASP1, XRCC1, TERF2, HMGN5, LRRC40, AK4, IDH3G, TPX2, TBCE, EIF2A, ALDH6A1, PTPN1, SPPL3, SNX27, PRPF40A, RAVER1, MCTS1, PPP1R12A, SYMPK, NAA15, RAC3, ZBTB10, EEF1A2, SLC4A7, EIF2AK2, USP28, SCCPDH, SCAF4, GINS1, HARS2, RBM12, PDS5B, SBDS, ADARB1, KITLG, ACTB, PSMG3, MAGEB2, TMOD1, BTF3, FBXW7, Cpsf6, NLRP7, DPP4, RCHY1, N, KLF12, FOS,

Top

Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPL35A	chr3	197677088	T	G	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_5	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
RPL35A	chr3	197677092	G	A	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_5	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
RPL35A	chr3	197677108	G	C	single_nucleotide_variant	Likely_benign	not_specified	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
RPL35A	chr3	197677666	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL35A	chr3	197677804	A	G	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_5	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL35A	chr3	197677808	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_5	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
RPL35A	chr3	197678023	G	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_5	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL35A	chr3	197678025	C	G	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_5	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL35A	chr3	197678039	C	T	single_nucleotide_variant	Benign/Likely_benign	Diamond-Blackfan_anemia_5\|not_specified	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL35A	chr3	197678052	G	A	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_5	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL35A	chr3	197678059	A	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_5	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL35A	chr3	197678073	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_5	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL35A	chr3	197678075	G	A	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_5	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL35A	chr3	197678095	CTCT	C	Microsatellite	Conflicting_interpretations_of_pathogenicity	Diamond-Blackfan_anemia_5\|not_provided	SO:0001822\|inframe_deletion,SO:0001627\|intron_variant	SO:0001822\|inframe_deletion,SO:0001627\|intron_variant
RPL35A	chr3	197678107	T	C	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_5	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL35A	chr3	197678115	G	A	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_5	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL35A	chr3	197678131	A	G	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_5	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL35A	chr3	197678134	CAG	C	Deletion	Pathogenic	Diamond-Blackfan_anemia_5	SO:0001589\|frameshift_variant,SO:0001627\|intron_variant	SO:0001589\|frameshift_variant,SO:0001627\|intron_variant
RPL35A	chr3	197678183	G	A	single_nucleotide_variant	Likely_pathogenic	Diamond-Blackfan_anemia_5	SO:0001575\|splice_donor_variant,SO:0001627\|intron_variant	SO:0001575\|splice_donor_variant,SO:0001627\|intron_variant
RPL35A	chr3	197680892	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_5	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL35A	chr3	197680893	G	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_5\|not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL35A	chr3	197680921	G	A	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_5	SO:0001587\|nonsense,SO:0001627\|intron_variant	SO:0001587\|nonsense,SO:0001627\|intron_variant
RPL35A	chr3	197680965	GC	G	Deletion	Pathogenic	Diamond-Blackfan_anemia_5	SO:0001589\|frameshift_variant,SO:0001627\|intron_variant	SO:0001589\|frameshift_variant,SO:0001627\|intron_variant
RPL35A	chr3	197680975	G	A	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_5	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL35A	chr3	197680980	A	G	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_5	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL35A	chr3	197680991	T	C	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_5	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL35A	chr3	197681013	C	T	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_5	SO:0001587\|nonsense,SO:0001627\|intron_variant	SO:0001587\|nonsense,SO:0001627\|intron_variant
RPL35A	chr3	197681022	A	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_5	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL35A	chr3	197681207	GT	G	Deletion	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL35A	chr3	197681217	T	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL35A	chr3	197681227	C	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL35A	chr3	197682555	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL35A	chr3	197682573	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL35A	chr3	197682650	C	T	single_nucleotide_variant	Benign/Likely_benign	Diamond-Blackfan_anemia_5\|not_specified	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
RPL35A	chr3	197682658	C	A	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_5	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
RPL35A	chr3	197682665	T	A	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_5	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
RPL35A	chr3	197682779	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
RPL35A	chr3	197682904	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL35A	UCEC	chr3	197678094	197678094	G	A	Missense_Mutation	p.A26T	2
RPL35A	LIHC	chr3	197678080	197678080	A	-	Frame_Shift_Del	p.Q21fs	2
RPL35A	UCEC	chr3	197678155	197678155	G	T	Missense_Mutation	p.R46I	2
RPL35A	PAAD	chr3	197680900	197680900	C	A	Missense_Mutation	p.P64Q	2
RPL35A	STAD	chr3	197678109	197678109	G	A	Missense_Mutation		2
RPL35A	STAD	chr3	197678109	197678109	G	A	Missense_Mutation	p.E31K	2
RPL35A	BLCA	chr3	197678160	197678160	G	A	Missense_Mutation	p.A48T	2
RPL35A	STAD	chr3	197678096	197678098	TCT	-	In_Frame_Del	p.26_27del	1
RPL35A	DLBC	chr3	197678057	197678057	C	T	Silent	p.G13G	1
RPL35A	STAD	chr3	197678096	197678098	TCT	-	In_Frame_Del	p.L28del	1
RPL35A	LIHC	chr3	197678059	197678059	A	G	Missense_Mutation	p.Y14C	1
RPL35A	PAAD	chr3	197680900	197680900	C	A	Missense_Mutation		1
RPL35A	PRAD	chr3	197678115	197678115	G	A	Missense_Mutation	p.V33I	1
RPL35A	SKCM	chr3	197680974	197680974	C	T	Nonsense_Mutation	p.R89X	1
RPL35A	SKCM	chr3	197680974	197680974	C	T	Nonsense_Mutation	p.R89*	1
RPL35A	BLCA	chr3	197678160	197678160	G	A	Missense_Mutation		1

Copy number variation (CNV) of RPL35A
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL35A
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101977	N/A	BF852302	AKAP13	chr15	86198989	-	RPL35A	chr3	197678052	+
101977	N/A	CA776035	DOCK7	chr1	62976292	-	RPL35A	chr3	197677087	+
101977	N/A	BF893174	FN1	chr2	216235227	+	RPL35A	chr3	197677064	+
101977	LUSC	TCGA-85-8664-01A	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+
101977	BRCA	TCGA-B6-A0RS-01A	IQCG	chr3	197686400	-	RPL35A	chr3	197680874	+
101977	N/A	CF124693	IQCG	chr3	197677092	+	RPL35A	chr3	197677062	+
101977	N/A	CF124701	IQCG	chr3	197677092	+	RPL35A	chr3	197677063	+
101977	N/A	EC559816	PLCE1	chr10	95836863	-	RPL35A	chr3	197680874	+
101977	N/A	EC575683	PRKG1	chr10	53344421	-	RPL35A	chr3	197677112	+
100056	N/A	DA779835	RPL35A	chr3	197681003	+	BPTF	chr17	65914828	+
97959	N/A	BF217777	RPL35A	chr3	197682676	+	BRCC3	chrX	154304656	+
97709	N/A	AA554649	RPL35A	chr3	197682722	+	BRIP1	chr17	59808433	+
102061	N/A	BI858652	RPL35A	chr3	197682722	+	C2CD3	chr11	73861358	+
100981	N/A	EC582733	RPL35A	chr3	197682722	+	CDH4	chr20	60512275	+
91133	N/A	BI856029	RPL35A	chr3	197682722	+	GNG7	chr19	2607528	+
102962	N/A	BG576138	RPL35A	chr3	197682722	+	KMT2E	chr7	104712086	-
90754	N/A	AA737125	RPL35A	chr3	197682658	+	LARS	chr5	145518569	-
100295	OV	TCGA-23-1120-01A	RPL35A	chr3	197681018	+	LPP	chr3	188202380	+
99013	N/A	BG034739	RPL35A	chr3	197682708	+	MAPK6	chr15	52320159	-
102773	N/A	CB048671	RPL35A	chr3	197682722	+	MELK	chr9	36616408	-
98486	N/A	BF687716	RPL35A	chr3	197682718	+	NXN	chr17	724159	+
85212	N/A	HI579411	RPL35A	chr3	197682722	+	PSME4	chr2	54126133	+
93718	STAD	TCGA-BR-A4QI-01A	RPL35A	chr3	197681018	+	RAF1	chr3	12633291	-
89746	N/A	BM015835	RPL35A	chr3	197682722	+	SLC25A17	chr22	41087369	+
101977	N/A	EC573461	SHROOM2	chrX	9916539	-	RPL35A	chr3	197678028	+
101977	STAD	TCGA-CD-5813	SPARCL1	chr4	88414733	-	RPL35A	chr3	197677806	+
101977	STAD	TCGA-CD-5813-01A	SPARCL1	chr4	88414734	-	RPL35A	chr3	197677807	+
101977	N/A	CB857203	USP39	chr2	85868097	-	RPL35A	chr3	197677059	+
101977	N/A	AK092633	ZNF391	chr6	27358698	+	RPL35A	chr3	197680924	+

Top

Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

Top

Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	RPL35A	0.00414641818530583	0.12
MESO	RPL35A	0.0071505961093859	0.19
BRCA	RPL35A	0.0100765440213204	0.26

Top

Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL35A	0.00191336655078847	0.061
LAML	RPL35A	0.0326681688421944	0.98
BRCA	RPL35A	0.00351059145546841	0.11
ESCA	RPL35A	0.00072036150648423	0.024

Top

Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1260899	Anemia, Diamond-Blackfan	2	GENOMICS_ENGLAND
C2675859	Diamond-Blackfan Anemia 5	1	CTD_human;GENOMICS_ENGLAND;UNIPROT