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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL37 (NCBI Gene ID:6167)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL37
	Gene ID: 6167
	Gene Symbol	RPL37
	Gene ID	6167
	Gene Name	ribosomal protein L37
	Synonyms	L37
	Cytomap	5p13.1
	Type of Gene	protein-coding
	Description	60S ribosomal protein L3760S ribosomal protein L37aG1.16large ribosomal subunit protein eL37
	Modification date	20200313
	UniProtAcc	P61927

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL37	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL37[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL37	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000274242	40834282	40834367	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRP	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL37	-2.87198822058464	8.03913394748564e-12

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL37 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	TSG	RPL37	GNB2L1	0.826393757	2.73E-12
DLBC	Cell metabolism gene	RPL37	PFDN4	0.805626337	4.99E-12
DLBC	Cell metabolism gene	RPL37	TBCA	0.817082227	1.41E-12
DLBC	Cell metabolism gene	RPL37	GEMIN7	0.819953225	1.01E-12
DLBC	Cell metabolism gene	RPL37	TOMM22	0.842157108	6.32E-14
DLBC	Cell metabolism gene	RPL37	TIMM9	0.842505687	6.03E-14
DLBC	Cell metabolism gene	RPL37	SNRPD2	0.850673062	1.94E-14
DLBC	Cell metabolism gene	RPL37	FAU	0.852417333	1.51E-14
DLBC	Cell metabolism gene	RPL37	NME2	0.852883518	1.41E-14
DLBC	Cell metabolism gene	RPL37	PFDN5	0.855491695	9.66E-15
DLBC	CGC	RPL37	NACA	0.869640047	1.06E-15
DLBC	TF	RPL37	NME2	0.852883518	1.41E-14
DLBC	TSG	RPL37	PARK7	0.812803385	2.28E-12
DLBC	TSG	RPL37	GADD45GIP1	0.827640299	4.05E-13
DLBC	TSG	RPL37	GNB2L1	0.915978943	7.25E-20
KICH	TSG	RPL37	GNB2L1	0.873774462	1.32E-29
KIRP	Cell metabolism gene	RPL37	SNRPD2	0.861478699	1.73E-96
KIRP	Cell metabolism gene	RPL37	FAU	0.863698642	1.56E-97
KIRP	TSG	RPL37	GNB2L1	0.852134151	2.77E-92
LGG	Cell metabolism gene	RPL37	FAU	0.821102165	1.10E-130
LGG	CGC	RPL37	NACA	0.85912478	9.91E-156
LGG	TSG	RPL37	GNB2L1	0.802321974	2.03E-120
LGG	TSG	RPL37	GAS5	0.852138099	1.31E-150
LIHC	Cell metabolism gene	RPL37	PFDN5	0.820249069	3.47E-104
LIHC	CGC	RPL37	NACA	0.800700971	1.00E-95
MESO	Cell metabolism gene	RPL37	FAU	0.826925349	5.81E-23
PAAD	Cell metabolism gene	RPL37	FAU	0.835469792	6.15E-49
PCPG	Cell metabolism gene	RPL37	PFDN5	0.815932301	6.79E-46
PCPG	TSG	RPL37	GNB2L1	0.835778766	4.73E-50
PRAD	Cell metabolism gene	RPL37	SNRPF	0.813307116	5.39E-131
PRAD	Cell metabolism gene	RPL37	TOMM7	0.814730676	8.20E-132
PRAD	Cell metabolism gene	RPL37	POLR2I	0.818106516	8.81E-134
PRAD	Cell metabolism gene	RPL37	TIMM9	0.828478416	4.26E-140
PRAD	Cell metabolism gene	RPL37	POLR2F	0.829792964	6.30E-141
PRAD	Cell metabolism gene	RPL37	PSMB7	0.829844449	5.84E-141
PRAD	Cell metabolism gene	RPL37	NME2	0.84012482	1.03E-147
PRAD	Cell metabolism gene	RPL37	FAU	0.8650856	2.53E-166
PRAD	Cell metabolism gene	RPL37	SNRPD2	0.876869191	1.86E-176
PRAD	CGC	RPL37	NACA	0.883912191	5.06E-183
PRAD	Epifactor	RPL37	FBL	0.859462268	8.04E-162
PRAD	TF	RPL37	NME2	0.84012482	1.03E-147
PRAD	TSG	RPL37	PDCD5	0.80809322	4.67E-128
PRAD	TSG	RPL37	GAS5	0.839676595	2.07E-147
PRAD	TSG	RPL37	GNB2L1	0.872691193	9.51E-173
TGCT	TSG	RPL37	GAS5	0.822643101	1.34E-39
THCA	Cell metabolism gene	RPL37	PFDN6	0.802566539	5.53E-130
THCA	Cell metabolism gene	RPL37	PFDN5	0.864425277	2.31E-172
THCA	Cell metabolism gene	RPL37	FAU	0.866879892	1.83E-174
THCA	Cell metabolism gene	RPL37	SNRPD2	0.883874674	2.96E-190
THCA	Epifactor	RPL37	FBL	0.802344057	7.36E-130
THCA	Epifactor	RPL37	TAF10	0.818929764	1.39E-139
THCA	TSG	RPL37	GNB2L1	0.83319535	8.84E-149
THYM	Cell metabolism gene	RPL37	SMPD2	0.800093534	2.11E-28
THYM	Cell metabolism gene	RPL37	POLD4	0.801499932	1.44E-28
THYM	Cell metabolism gene	RPL37	PSMB1	0.803319773	8.80E-29
THYM	Cell metabolism gene	RPL37	DTYMK	0.803707701	7.92E-29
THYM	Cell metabolism gene	RPL37	MVD	0.804336697	6.66E-29
THYM	Cell metabolism gene	RPL37	PSMA4	0.805248073	5.18E-29
THYM	Cell metabolism gene	RPL37	MIF	0.805491252	4.85E-29
THYM	Cell metabolism gene	RPL37	SNRPD1	0.805585126	4.72E-29
THYM	Cell metabolism gene	RPL37	GMPPA	0.807609146	2.69E-29
THYM	Cell metabolism gene	RPL37	HSD17B10	0.808264811	2.24E-29
THYM	Cell metabolism gene	RPL37	LSM3	0.809161115	1.74E-29
THYM	Cell metabolism gene	RPL37	PSMB4	0.809670327	1.51E-29
THYM	Cell metabolism gene	RPL37	TBCB	0.810177177	1.30E-29
THYM	Cell metabolism gene	RPL37	PGP	0.810716947	1.12E-29
THYM	Cell metabolism gene	RPL37	TOMM5	0.810783324	1.10E-29
THYM	Cell metabolism gene	RPL37	IDH3G	0.819473619	8.62E-31
THYM	Cell metabolism gene	RPL37	SEC61B	0.821359524	4.87E-31
THYM	Cell metabolism gene	RPL37	EXOSC4	0.822389965	3.56E-31
THYM	Cell metabolism gene	RPL37	PSME2	0.822933662	3.01E-31
THYM	Cell metabolism gene	RPL37	SRM	0.824035233	2.14E-31
THYM	Cell metabolism gene	RPL37	HMBS	0.826066694	1.14E-31
THYM	Cell metabolism gene	RPL37	PFDN6	0.82651058	9.91E-32
THYM	Cell metabolism gene	RPL37	TIMM9	0.826618067	9.59E-32
THYM	Cell metabolism gene	RPL37	PSME1	0.827932765	6.33E-32
THYM	Cell metabolism gene	RPL37	TIMM10	0.829806396	3.48E-32
THYM	Cell metabolism gene	RPL37	PSMB10	0.830103583	3.16E-32
THYM	Cell metabolism gene	RPL37	PAFAH1B3	0.830241178	3.03E-32
THYM	Cell metabolism gene	RPL37	TAZ	0.832823137	1.31E-32
THYM	Cell metabolism gene	RPL37	GEMIN7	0.833124023	1.19E-32
THYM	Cell metabolism gene	RPL37	TOMM40	0.833675605	9.90E-33
THYM	Cell metabolism gene	RPL37	NANS	0.833971582	8.98E-33
THYM	Cell metabolism gene	RPL37	PSMC1	0.835631311	5.18E-33
THYM	Cell metabolism gene	RPL37	SNRPF	0.835905635	4.73E-33
THYM	Cell metabolism gene	RPL37	SNRPB	0.836954882	3.32E-33
THYM	Cell metabolism gene	RPL37	EXOSC1	0.837941566	2.38E-33
THYM	Cell metabolism gene	RPL37	DPM2	0.838658734	1.87E-33
THYM	Cell metabolism gene	RPL37	LSM2	0.839187429	1.56E-33
THYM	Cell metabolism gene	RPL37	TIMM17B	0.839421819	1.44E-33
THYM	Cell metabolism gene	RPL37	MTX1	0.839531574	1.39E-33
THYM	Cell metabolism gene	RPL37	TXN	0.841731935	6.49E-34
THYM	Cell metabolism gene	RPL37	TOMM22	0.843280241	3.78E-34
THYM	Cell metabolism gene	RPL37	LSM4	0.844543351	2.42E-34
THYM	Cell metabolism gene	RPL37	PSMD13	0.847585832	8.12E-35
THYM	Cell metabolism gene	RPL37	SNRPE	0.848955767	4.93E-35
THYM	Cell metabolism gene	RPL37	EXOSC5	0.851167647	2.18E-35
THYM	Cell metabolism gene	RPL37	PSMD4	0.85285094	1.16E-35
THYM	Cell metabolism gene	RPL37	PSMC3	0.853145821	1.04E-35
THYM	Cell metabolism gene	RPL37	SEC61G	0.853989466	7.55E-36
THYM	Cell metabolism gene	RPL37	POLR2F	0.857005117	2.37E-36
THYM	Cell metabolism gene	RPL37	PHKG2	0.8621726	3.06E-37
THYM	Cell metabolism gene	RPL37	LSM5	0.862983852	2.20E-37
THYM	Cell metabolism gene	RPL37	SNRPD3	0.863979169	1.47E-37
THYM	Cell metabolism gene	RPL37	GUK1	0.864322455	1.27E-37
THYM	Cell metabolism gene	RPL37	GEMIN6	0.865012962	9.59E-38
THYM	Cell metabolism gene	RPL37	DGUOK	0.867004181	4.18E-38
THYM	Cell metabolism gene	RPL37	ITPA	0.868975398	1.81E-38
THYM	Cell metabolism gene	RPL37	PGLS	0.869173467	1.67E-38
THYM	Cell metabolism gene	RPL37	TIMM13	0.870124327	1.11E-38
THYM	Cell metabolism gene	RPL37	DPM3	0.870490347	9.46E-39
THYM	Cell metabolism gene	RPL37	WBSCR22	0.872357735	4.19E-39
THYM	Cell metabolism gene	RPL37	POLR2I	0.873254637	2.82E-39
THYM	Cell metabolism gene	RPL37	TIMM50	0.877453964	4.26E-40
THYM	Cell metabolism gene	RPL37	APRT	0.877837147	3.57E-40
THYM	Cell metabolism gene	RPL37	SSR2	0.880315492	1.13E-40
THYM	Cell metabolism gene	RPL37	ACOT8	0.880968017	8.28E-41
THYM	Cell metabolism gene	RPL37	PFDN5	0.881119346	7.71E-41
THYM	Cell metabolism gene	RPL37	SLC27A5	0.882232914	4.54E-41
THYM	Cell metabolism gene	RPL37	EBP	0.882886783	3.31E-41
THYM	Cell metabolism gene	RPL37	POLR2J	0.884353524	1.63E-41
THYM	Cell metabolism gene	RPL37	PSMB7	0.887318696	3.75E-42
THYM	Cell metabolism gene	RPL37	PSMB3	0.890800694	6.35E-43
THYM	Cell metabolism gene	RPL37	POLR2H	0.900110466	4.02E-45
THYM	Cell metabolism gene	RPL37	TIMM8B	0.916898748	1.07E-49
THYM	Cell metabolism gene	RPL37	FAU	0.917482967	7.16E-50
THYM	Cell metabolism gene	RPL37	SNRPD2	0.924044855	6.05E-52
THYM	CGC	RPL37	MGMT	0.801306496	1.52E-28
THYM	CGC	RPL37	RBM10	0.810579355	1.16E-29
THYM	CGC	RPL37	TFPT	0.84569828	1.60E-34
THYM	CGC	RPL37	COX6C	0.84765036	7.93E-35
THYM	CGC	RPL37	SDHAF2	0.852011805	1.59E-35
THYM	Epifactor	RPL37	HIST2H2AC	0.802499975	1.10E-28
THYM	Epifactor	RPL37	ZGPAT	0.803705386	7.92E-29
THYM	Epifactor	RPL37	LAS1L	0.808510198	2.09E-29
THYM	Epifactor	RPL37	RBX1	0.816644515	2.00E-30
THYM	Epifactor	RPL37	RRP8	0.820638283	6.06E-31
THYM	Epifactor	RPL37	CDK5	0.820736999	5.89E-31
THYM	Epifactor	RPL37	EXOSC4	0.822389965	3.56E-31
THYM	Epifactor	RPL37	PPP4C	0.832700876	1.36E-32
THYM	Epifactor	RPL37	RUVBL2	0.835666593	5.12E-33
THYM	Epifactor	RPL37	C17orf49	0.836712687	3.61E-33
THYM	Epifactor	RPL37	EXOSC1	0.837941566	2.38E-33
THYM	Epifactor	RPL37	TFPT	0.84569828	1.60E-34
THYM	Epifactor	RPL37	CCDC101	0.845957013	1.46E-34
THYM	Epifactor	RPL37	EXOSC5	0.851167647	2.18E-35
THYM	Epifactor	RPL37	SS18L2	0.853139136	1.04E-35
THYM	Epifactor	RPL37	PRPF31	0.857781075	1.75E-36
THYM	Epifactor	RPL37	INO80E	0.871944929	5.03E-39
THYM	Epifactor	RPL37	FBL	0.877251378	4.67E-40
THYM	Epifactor	RPL37	SIRT6	0.887931088	2.76E-42
THYM	Epifactor	RPL37	ZNHIT1	0.899817149	4.75E-45
THYM	Epifactor	RPL37	BRMS1	0.9051524	2.10E-46
THYM	Epifactor	RPL37	TAF10	0.91482915	4.41E-49
THYM	IUPHAR	RPL37	SMPD2	0.800093534	2.11E-28
THYM	IUPHAR	RPL37	PSMB1	0.803319773	8.80E-29
THYM	IUPHAR	RPL37	MVD	0.804336697	6.66E-29
THYM	IUPHAR	RPL37	CDK5	0.820736999	5.89E-31
THYM	IUPHAR	RPL37	PHKG2	0.8621726	3.06E-37
THYM	IUPHAR	RPL37	PPIA	0.864550305	1.16E-37
THYM	IUPHAR	RPL37	SLC27A5	0.882232914	4.54E-41
THYM	IUPHAR	RPL37	SIRT6	0.887931088	2.76E-42
THYM	Kinase	RPL37	CDK5	0.820736999	5.89E-31
THYM	Kinase	RPL37	PHKG2	0.8621726	3.06E-37
THYM	TF	RPL37	ZGPAT	0.803705386	7.92E-29
THYM	TF	RPL37	GLI4	0.804061197	7.19E-29
THYM	TF	RPL37	THAP3	0.804348781	6.64E-29
THYM	TF	RPL37	GTF3A	0.804487111	6.39E-29
THYM	TF	RPL37	ZNF394	0.805762717	4.50E-29
THYM	TF	RPL37	ZNF511	0.808448725	2.13E-29
THYM	TF	RPL37	ZNF581	0.809362867	1.64E-29
THYM	TF	RPL37	THAP7	0.816591176	2.03E-30
THYM	TF	RPL37	ZNF444	0.821220916	5.08E-31
THYM	TF	RPL37	RBCK1	0.822813839	3.12E-31
THYM	TF	RPL37	ZNF32	0.823973983	2.19E-31
THYM	TF	RPL37	ZNF428	0.830384883	2.89E-32
THYM	TF	RPL37	THYN1	0.839369802	1.46E-33
THYM	TF	RPL37	IRF3	0.839946216	1.20E-33
THYM	TF	RPL37	ZNF688	0.846107051	1.38E-34
THYM	TF	RPL37	ZNF787	0.850930264	2.38E-35
THYM	TF	RPL37	USF1	0.852413772	1.37E-35
THYM	TF	RPL37	DRAP1	0.853168623	1.03E-35
THYM	TF	RPL37	ETV2	0.853272315	9.91E-36
THYM	TSG	RPL37	AIP	0.802717891	1.04E-28
THYM	TSG	RPL37	PFN1	0.804301519	6.73E-29
THYM	TSG	RPL37	HTRA2	0.813253303	5.40E-30
THYM	TSG	RPL37	GABARAP	0.82754139	7.16E-32
THYM	TSG	RPL37	PARK7	0.833291833	1.12E-32
THYM	TSG	RPL37	TSSC4	0.83526189	5.86E-33
THYM	TSG	RPL37	ST20	0.83649399	3.88E-33
THYM	TSG	RPL37	IRF3	0.839946216	1.20E-33
THYM	TSG	RPL37	GLTSCR2	0.852717646	1.22E-35
THYM	TSG	RPL37	GADD45GIP1	0.877646273	3.90E-40
THYM	TSG	RPL37	NPRL2	0.880477303	1.04E-40
THYM	TSG	RPL37	SIRT6	0.887931088	2.76E-42
THYM	TSG	RPL37	GNB2L1	0.897832617	1.45E-44
THYM	TSG	RPL37	BRMS1	0.9051524	2.10E-46
UCS	Cell metabolism gene	RPL37	SMPD2	0.800093534	2.11E-28
UCS	Cell metabolism gene	RPL37	POLD4	0.801499932	1.44E-28
UCS	Cell metabolism gene	RPL37	PSMB1	0.803319773	8.80E-29
UCS	Cell metabolism gene	RPL37	DTYMK	0.803707701	7.92E-29
UCS	Cell metabolism gene	RPL37	MVD	0.804336697	6.66E-29
UCS	Cell metabolism gene	RPL37	PSMA4	0.805248073	5.18E-29
UCS	Cell metabolism gene	RPL37	MIF	0.805491252	4.85E-29
UCS	Cell metabolism gene	RPL37	SNRPD1	0.805585126	4.72E-29
UCS	Cell metabolism gene	RPL37	GMPPA	0.807609146	2.69E-29
UCS	Cell metabolism gene	RPL37	HSD17B10	0.808264811	2.24E-29
UCS	Cell metabolism gene	RPL37	LSM3	0.809161115	1.74E-29
UCS	Cell metabolism gene	RPL37	PSMB4	0.809670327	1.51E-29
UCS	Cell metabolism gene	RPL37	TBCB	0.810177177	1.30E-29
UCS	Cell metabolism gene	RPL37	PGP	0.810716947	1.12E-29
UCS	Cell metabolism gene	RPL37	TOMM5	0.810783324	1.10E-29
UCS	Cell metabolism gene	RPL37	IDH3G	0.819473619	8.62E-31
UCS	Cell metabolism gene	RPL37	SEC61B	0.821359524	4.87E-31
UCS	Cell metabolism gene	RPL37	EXOSC4	0.822389965	3.56E-31
UCS	Cell metabolism gene	RPL37	PSME2	0.822933662	3.01E-31
UCS	Cell metabolism gene	RPL37	SRM	0.824035233	2.14E-31
UCS	Cell metabolism gene	RPL37	HMBS	0.826066694	1.14E-31
UCS	Cell metabolism gene	RPL37	PFDN6	0.82651058	9.91E-32
UCS	Cell metabolism gene	RPL37	TIMM9	0.826618067	9.59E-32
UCS	Cell metabolism gene	RPL37	PSME1	0.827932765	6.33E-32
UCS	Cell metabolism gene	RPL37	TIMM10	0.829806396	3.48E-32
UCS	Cell metabolism gene	RPL37	PSMB10	0.830103583	3.16E-32
UCS	Cell metabolism gene	RPL37	PAFAH1B3	0.830241178	3.03E-32
UCS	Cell metabolism gene	RPL37	TAZ	0.832823137	1.31E-32
UCS	Cell metabolism gene	RPL37	GEMIN7	0.833124023	1.19E-32
UCS	Cell metabolism gene	RPL37	TOMM40	0.833675605	9.90E-33
UCS	Cell metabolism gene	RPL37	NANS	0.833971582	8.98E-33
UCS	Cell metabolism gene	RPL37	PSMC1	0.835631311	5.18E-33
UCS	Cell metabolism gene	RPL37	SNRPF	0.835905635	4.73E-33
UCS	Cell metabolism gene	RPL37	SNRPB	0.836954882	3.32E-33
UCS	Cell metabolism gene	RPL37	EXOSC1	0.837941566	2.38E-33
UCS	Cell metabolism gene	RPL37	DPM2	0.838658734	1.87E-33
UCS	Cell metabolism gene	RPL37	LSM2	0.839187429	1.56E-33
UCS	Cell metabolism gene	RPL37	TIMM17B	0.839421819	1.44E-33
UCS	Cell metabolism gene	RPL37	MTX1	0.839531574	1.39E-33
UCS	Cell metabolism gene	RPL37	TXN	0.841731935	6.49E-34
UCS	Cell metabolism gene	RPL37	TOMM22	0.843280241	3.78E-34
UCS	Cell metabolism gene	RPL37	LSM4	0.844543351	2.42E-34
UCS	Cell metabolism gene	RPL37	PSMD13	0.847585832	8.12E-35
UCS	Cell metabolism gene	RPL37	SNRPE	0.848955767	4.93E-35
UCS	Cell metabolism gene	RPL37	EXOSC5	0.851167647	2.18E-35
UCS	Cell metabolism gene	RPL37	PSMD4	0.85285094	1.16E-35
UCS	Cell metabolism gene	RPL37	PSMC3	0.853145821	1.04E-35
UCS	Cell metabolism gene	RPL37	SEC61G	0.853989466	7.55E-36
UCS	Cell metabolism gene	RPL37	POLR2F	0.857005117	2.37E-36
UCS	Cell metabolism gene	RPL37	PHKG2	0.8621726	3.06E-37
UCS	Cell metabolism gene	RPL37	LSM5	0.862983852	2.20E-37
UCS	Cell metabolism gene	RPL37	SNRPD3	0.863979169	1.47E-37
UCS	Cell metabolism gene	RPL37	GUK1	0.864322455	1.27E-37
UCS	Cell metabolism gene	RPL37	GEMIN6	0.865012962	9.59E-38
UCS	Cell metabolism gene	RPL37	DGUOK	0.867004181	4.18E-38
UCS	Cell metabolism gene	RPL37	ITPA	0.868975398	1.81E-38
UCS	Cell metabolism gene	RPL37	PGLS	0.869173467	1.67E-38
UCS	Cell metabolism gene	RPL37	TIMM13	0.870124327	1.11E-38
UCS	Cell metabolism gene	RPL37	DPM3	0.870490347	9.46E-39
UCS	Cell metabolism gene	RPL37	WBSCR22	0.872357735	4.19E-39
UCS	Cell metabolism gene	RPL37	POLR2I	0.873254637	2.82E-39
UCS	Cell metabolism gene	RPL37	TIMM50	0.877453964	4.26E-40
UCS	Cell metabolism gene	RPL37	APRT	0.877837147	3.57E-40
UCS	Cell metabolism gene	RPL37	SSR2	0.880315492	1.13E-40
UCS	Cell metabolism gene	RPL37	ACOT8	0.880968017	8.28E-41
UCS	Cell metabolism gene	RPL37	PFDN5	0.881119346	7.71E-41
UCS	Cell metabolism gene	RPL37	SLC27A5	0.882232914	4.54E-41
UCS	Cell metabolism gene	RPL37	EBP	0.882886783	3.31E-41
UCS	Cell metabolism gene	RPL37	POLR2J	0.884353524	1.63E-41
UCS	Cell metabolism gene	RPL37	PSMB7	0.887318696	3.75E-42
UCS	Cell metabolism gene	RPL37	PSMB3	0.890800694	6.35E-43
UCS	Cell metabolism gene	RPL37	POLR2H	0.900110466	4.02E-45
UCS	Cell metabolism gene	RPL37	TIMM8B	0.916898748	1.07E-49
UCS	Cell metabolism gene	RPL37	FAU	0.917482967	7.16E-50
UCS	Cell metabolism gene	RPL37	SNRPD2	0.924044855	6.05E-52
UCS	CGC	RPL37	MGMT	0.801306496	1.52E-28
UCS	CGC	RPL37	RBM10	0.810579355	1.16E-29
UCS	CGC	RPL37	TFPT	0.84569828	1.60E-34
UCS	CGC	RPL37	COX6C	0.84765036	7.93E-35
UCS	CGC	RPL37	SDHAF2	0.852011805	1.59E-35
UCS	Epifactor	RPL37	HIST2H2AC	0.802499975	1.10E-28
UCS	Epifactor	RPL37	ZGPAT	0.803705386	7.92E-29
UCS	Epifactor	RPL37	LAS1L	0.808510198	2.09E-29
UCS	Epifactor	RPL37	RBX1	0.816644515	2.00E-30
UCS	Epifactor	RPL37	RRP8	0.820638283	6.06E-31
UCS	Epifactor	RPL37	CDK5	0.820736999	5.89E-31
UCS	Epifactor	RPL37	EXOSC4	0.822389965	3.56E-31
UCS	Epifactor	RPL37	PPP4C	0.832700876	1.36E-32
UCS	Epifactor	RPL37	RUVBL2	0.835666593	5.12E-33
UCS	Epifactor	RPL37	C17orf49	0.836712687	3.61E-33
UCS	Epifactor	RPL37	EXOSC1	0.837941566	2.38E-33
UCS	Epifactor	RPL37	TFPT	0.84569828	1.60E-34
UCS	Epifactor	RPL37	CCDC101	0.845957013	1.46E-34
UCS	Epifactor	RPL37	EXOSC5	0.851167647	2.18E-35
UCS	Epifactor	RPL37	SS18L2	0.853139136	1.04E-35
UCS	Epifactor	RPL37	PRPF31	0.857781075	1.75E-36
UCS	Epifactor	RPL37	INO80E	0.871944929	5.03E-39
UCS	Epifactor	RPL37	FBL	0.877251378	4.67E-40
UCS	Epifactor	RPL37	SIRT6	0.887931088	2.76E-42
UCS	Epifactor	RPL37	ZNHIT1	0.899817149	4.75E-45
UCS	Epifactor	RPL37	BRMS1	0.9051524	2.10E-46
UCS	Epifactor	RPL37	TAF10	0.91482915	4.41E-49
UCS	IUPHAR	RPL37	SMPD2	0.800093534	2.11E-28
UCS	IUPHAR	RPL37	PSMB1	0.803319773	8.80E-29
UCS	IUPHAR	RPL37	MVD	0.804336697	6.66E-29
UCS	IUPHAR	RPL37	CDK5	0.820736999	5.89E-31
UCS	IUPHAR	RPL37	PHKG2	0.8621726	3.06E-37
UCS	IUPHAR	RPL37	PPIA	0.864550305	1.16E-37
UCS	IUPHAR	RPL37	SLC27A5	0.882232914	4.54E-41
UCS	IUPHAR	RPL37	SIRT6	0.887931088	2.76E-42
UCS	Kinase	RPL37	CDK5	0.820736999	5.89E-31
UCS	Kinase	RPL37	PHKG2	0.8621726	3.06E-37
UCS	TF	RPL37	ZGPAT	0.803705386	7.92E-29
UCS	TF	RPL37	GLI4	0.804061197	7.19E-29
UCS	TF	RPL37	THAP3	0.804348781	6.64E-29
UCS	TF	RPL37	GTF3A	0.804487111	6.39E-29
UCS	TF	RPL37	ZNF394	0.805762717	4.50E-29
UCS	TF	RPL37	ZNF511	0.808448725	2.13E-29
UCS	TF	RPL37	ZNF581	0.809362867	1.64E-29
UCS	TF	RPL37	THAP7	0.816591176	2.03E-30
UCS	TF	RPL37	ZNF444	0.821220916	5.08E-31
UCS	TF	RPL37	RBCK1	0.822813839	3.12E-31
UCS	TF	RPL37	ZNF32	0.823973983	2.19E-31
UCS	TF	RPL37	ZNF428	0.830384883	2.89E-32
UCS	TF	RPL37	THYN1	0.839369802	1.46E-33
UCS	TF	RPL37	IRF3	0.839946216	1.20E-33
UCS	TF	RPL37	ZNF688	0.846107051	1.38E-34
UCS	TF	RPL37	ZNF787	0.850930264	2.38E-35
UCS	TF	RPL37	USF1	0.852413772	1.37E-35
UCS	TF	RPL37	DRAP1	0.853168623	1.03E-35
UCS	TF	RPL37	ETV2	0.853272315	9.91E-36
UCS	TSG	RPL37	AIP	0.802717891	1.04E-28
UCS	TSG	RPL37	PFN1	0.804301519	6.73E-29
UCS	TSG	RPL37	HTRA2	0.813253303	5.40E-30
UCS	TSG	RPL37	GABARAP	0.82754139	7.16E-32
UCS	TSG	RPL37	PARK7	0.833291833	1.12E-32
UCS	TSG	RPL37	TSSC4	0.83526189	5.86E-33
UCS	TSG	RPL37	ST20	0.83649399	3.88E-33
UCS	TSG	RPL37	IRF3	0.839946216	1.20E-33
UCS	TSG	RPL37	GLTSCR2	0.852717646	1.22E-35
UCS	TSG	RPL37	GADD45GIP1	0.877646273	3.90E-40
UCS	TSG	RPL37	NPRL2	0.880477303	1.04E-40
UCS	TSG	RPL37	SIRT6	0.887931088	2.76E-42
UCS	TSG	RPL37	GNB2L1	0.897832617	1.45E-44
UCS	TSG	RPL37	BRMS1	0.9051524	2.10E-46
UVM	Cell metabolism gene	RPL37	SSR2	0.869465399	1.33E-25
UVM	Cell metabolism gene	RPL37	FAU	0.915343988	1.51E-32
UVM	CGC	RPL37	NACA	0.837903627	3.30E-22
UVM	Epifactor	RPL37	FBL	0.929733742	1.39E-35
UVM	TF	RPL37	ZNF581	0.852161783	1.21E-23
UVM	TSG	RPL37	GNB2L1	0.907270476	4.50E-31
UVM	TSG	RPL37	GLTSCR2	0.908276875	3.00E-31

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL37	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL37	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL37	RPS16	-1.35957043617517	0.00019507110118866
STAD	RPL37	RPS23	1.85076760664576	0.000364991836249828
COAD	RPL37	RPL13	2.11745314482912	0.000465095043182374
KIRP	RPL37	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL37	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL37	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL37	RPL19	1.36901182894089	0.00250792503356934
LUAD	RPL37	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL37	RPS16	-6.16322798156577	0.0115764821363307
LUSC	RPL37	RPS23	1.46751169891047	0.0174932185880974
BLCA	RPL37	RPS27A	-1.04747470069188	0.0258216857910156
STAD	RPL37	RPL13	-1.17078722854876	0.0294188209809363
COAD	RPL37	RPS11	1.35307548998204	0.0312207043170929
KICH	RPL37	RPL13	-5.95618047175394	0.0366820693016052
COAD	RPL37	RPS9	1.18612014402235	0.0381683111190796
LUSC	RPL37	RPL19	-2.14669889516666	0.044366810398747
UCEC	RPL37	RPS23	-2.03658159814007	0.046875
KIRC	RPL37	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL37	RPS9	1.9331477546349	2.31299392089389e-07
KIRC	RPL37	RPL13	-3.44015571111292	2.58914497097505e-10
KIRC	RPL37	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL37	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL37	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL37	RPS9	-1.32680816440987	6.53264115309597e-07
KIRC	RPL37	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL37	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRP	RPL37	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL37	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL37

DDX56, APP, RPL30, RPL27, RPS9, MFAP1, PAN2, MDM2, MDM4, WIF1, TCF3, SQSTM1, POLR1B, ABL1, ARAF, CDK2, MAST3, SRPK1, RPL35A, RPS11, RPS13, RPS15, RPS15A, RPS3, RTF1, RPL37A, UBA52, BLM, SRPK2, NPM1, Tmed10, CDH1, TRIM25, HIF1AN, LARP7, ATG16L1, NR2C2, RPS6KA3, SNRNP70, WWP2, OBSL1, PLEKHA4, ZC3H18, GRB10, HCK, PTPN12, PTPN6, HSCB, AURKB, KIF14, KIF20A, PRC1, NR3C1, PAGE4, MRPL48, MRPL2, MRPL50, ZFP91, GADD45GIP1, MRPL9, MRPL11, MRPL37, MRPL51, MRPL32, MRPL45, LSM14B, MRS2, ICT1, MRPL4, MRPL13, MRPS18A, MRPL17, MRPL24, PBRM1, MRPL40, MRPL38, MRPL47, RNF220, MRPL35, GNLY, YBX2, MRPL3, MRPL28, MRPL55, MRPL39, EIF2B1, DHX57, IPO5, MRPS9, MRPL27, MRPL30, MRPL16, MRPL44, MRPL1, ILF3, MRPL10, MRPL42, MRPL49, MRPL22, HIST1H1A, SS18L2, BRD7, DDX21, MRPS18C, MRPL21, MRPL43, MRPL23, MRPS30, PHF10, MRPS31, ZNF579, MRPL57, MRPL18, RPL26L1, MRPL15, MRPS7, H2AFX, C1QBP, RANBP6, MRPL20, MYO1D, CTTN, DPP4, CALCOCO2, N, NKX2-5,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL37	DLBC	chr5	40832665	40832665	G	A	Missense_Mutation	p.R79C	3
RPL37	BLCA	chr5	40834293	40834293	G	A	Missense_Mutation	p.R72C	2
RPL37	LUAD	chr5	40834695	40834695	G	A	Missense_Mutation	p.S6L	2
RPL37	STAD	chr5	40834687	40834687	C	T	Missense_Mutation	p.G9R	2
RPL37	UCEC	chr5	40834271	40834271	T	C	Missense_Mutation	p.Y79C	2
RPL37	UCEC	chr5	40834304	40834304	T	A	Missense_Mutation	p.K68I	2
RPL37	PRAD	chr5	40834355	40834355	G	C	Missense_Mutation	p.A51G	2
RPL37	BLCA	chr5	40834706	40834706	C	T	Silent	p.T2T	1
RPL37	LIHC	chr5	40834674	40834674	T	C	Missense_Mutation	p.N13S	1
RPL37	SKCM	chr5	40832606	40832606	T	C	Silent	p.X98X	1
RPL37	SKCM	chr5	40832606	40832606	T	C	Missense_Mutation	p.K70R	1
RPL37	LUAD	chr5	40834631	40834631	G	C	Nonsense_Mutation	p.Y27*	1
RPL37	DLBC	chr5	40834595	40834595	G	A	Silent	p.Y39Y	1
RPL37	LUSC	chr5	40834286	40834286	A	G	Missense_Mutation	p.F74S	1
RPL37	HNSC	chr5	40834693	40834693	A	T	Missense_Mutation		1
RPL37	MESO	chr5	40834613	40834613	G	A	Silent		1
RPL37	HNSC	chr5	40834692	40834692	G	T	Nonsense_Mutation	p.S7*	1
RPL37	MESO	chr5	40834613	40834613	G	A	Silent	p.T33T	1
RPL37	HNSC	chr5	40834693	40834693	A	T	Missense_Mutation	p.S7T	1
RPL37	OV	chr5	40835298	40835298	C	T	Silent	p.P5	1
RPL37	HNSC	chr5	40834692	40834693	GA	TT	Missense_Mutation	p.S7K	1
RPL37	PAAD	chr5	40834265	40834265	C	A	Missense_Mutation		1
RPL37	KICH	chr5	40835296	40835296	T	A	Missense_Mutation		1
RPL37	BLCA	chr5	40834706	40834706	C	T	Silent		1
RPL37	KIRC	chr5	40834595	40834596	-	T	Frame_Shift_Ins	p.Y39_P40delinsX	1
RPL37	READ	chr5	40834599	40834599	C	T	Missense_Mutation	p.G38D	1
RPL37	BLCA	chr5	40834293	40834293	G	A	Missense_Mutation		1
RPL37	LIHC	chr5	40835365	40835365	G	A	Missense_Mutation		1
RPL37	SARC	chr5	40834349	40834349	G	T	Missense_Mutation		1

Copy number variation (CNV) of RPL37
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL37
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
94362	N/A	AA573016	ARFGEF1	chr8	68098649	-	RPL37	chr5	40832561	+
94362	Non-Cancer	ERR188317	ATHL1	chr11	296072	+	RPL37	chr5	40834710	-
94362	N/A	BI491379	C4orf50	chr4	5912995	+	RPL37	chr5	40832556	+
94362	STAD	TCGA-HU-8238-01A	CPOX	chr3	98309476	-	RPL37	chr5	40828053	-
94362	N/A	AA736533	EPS15L1	chr19	16578329	-	RPL37	chr5	40832561	+
94362	N/A	AJ705329	MBOAT1	chr6	20124933	-	RPL37	chr5	40834357	-
94362	N/A	BI494816	MLKL	chr16	74707850	-	RPL37	chr5	40832558	+
94362	LUSC	TCGA-21-1081	PDGFC	chr4	157700244	-	RPL37	chr5	40835311	-
94362	BRCA	TCGA-B6-A0RS	PRKAA1	chr5	40798164	-	RPL37	chr5	40834708	-
94362	BRCA	TCGA-B6-A0RS-01A	PRKAA1	chr5	40798165	-	RPL37	chr5	40834708	-
94362	N/A	AA935969	RGS6	chr14	72379559	+	RPL37	chr5	40832558	+
94182	N/A	CF123102	RPL37	chr5	40832558	-	ANKH	chr5	14809446	+
85859	N/A	AX396374	RPL37	chr5	40832566	-	ANKRD54	chr22	38227664	-
76757	STAD	TCGA-CD-8525-01A	RPL37	chr5	40834624	-	ATP5E	chr20	57603868	-
101632	N/A	BG577316	RPL37	chr5	40832558	-	BCAS3	chr17	59291882	+
96446	STAD	TCGA-D7-5577-01A	RPL37	chr5	40834283	-	CAPNS1	chr19	36636878	+
76757	STAD	TCGA-HU-A4GT-01A	RPL37	chr5	40832544	-	CLP1	chr11	57428237	+
102818	N/A	BI493286	RPL37	chr5	40825572	+	CSMD2	chr1	34393546	+
76757	COAD	TCGA-AA-A03F-01A	RPL37	chr5	40834635	-	GTF2F1	chr19	6379955	-
76757	N/A	BP222766	RPL37	chr5	40832558	-	ITGBL1	chr13	102290776	+
98409	OV	TCGA-13-0887	RPL37	chr5	40834282	-	MPHOSPH9	chr12	123641455	-
89602	OV	TCGA-13-0768-01A	RPL37	chr5	40834352	-	MTRNR2L8	chr11	10530513	-
76757	N/A	AW023609	RPL37	chr5	40832558	-	TMPRSS9	chr19	2400598	+
97374	N/A	CB054820	RPL37	chr5	40832558	-	TRPC4AP	chr20	33667815	+
91564	LIHC	TCGA-UB-A7ME-01A	RPL37	chr5	40832544	-	TTC33	chr5	40513171	-
76757	COAD	TCGA-AA-3844-01A	RPL37	chr5	40834295	-	TTC40	chr10	134726712	-
76757	N/A	AW020320	RPL37	chr5	40832556	-	XYLB	chr3	38440352	+
94362	N/A	AA635681	TOM1L2	chr17	17849187	+	RPL37	chr5	40832558	+
94370	N/A	CB054604	TRPC4AP	chr20	33667815	-	RPL37	chr5	40832558	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
LGG	RPL37	0.593690430919222	-0.521397255539252	0.000789877318840059	0.000594359234150009	0.000950250610913674	525
ACC	RPL37	2.19329702236009	0.785405901377103	0.00295749722345805	0.0025068678717823	0.0023931596866757	79
KIRC	RPL37	1.26072879229955	0.231689960337713	0.02182526899634	0.0242616349925681	0.022367892956296	604
KIRC	RPL37	1.26072879229955	0.231689960337713	0.02182526899634	0.0242616349925681	0.022367892956296	604
UVM	RPL37	0.54003006271789	-0.616130469273632	0.0267404983245062	0.028681187100264	0.0242584350344962	80

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPL37	0.000449045272876128	0.013
ACC	RPL37	0.0027546011618848	0.074

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPL37	0.0383470206403403	1
BRCA	RPL37	0.00221525230527338	0.073
SARC	RPL37	0.0464505470349769	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P61927	DB04602	PUROMYCIN AMINONUCLEOSIDE-5'-MONOPHOSPHATE		Small molecule	Experimental
P61927	DB04805	Virginiamycin S1		Small molecule	Experimental
P61927	DB04602	PUROMYCIN AMINONUCLEOSIDE-5'-MONOPHOSPHATE
P61927	DB04805	Virginiamycin S1

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source