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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL38 (NCBI Gene ID:6169)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL38
	Gene ID: 6169
	Gene Symbol	RPL38
	Gene ID	6169
	Gene Name	ribosomal protein L38
	Synonyms	L38
	Cytomap	17q25.1
	Type of Gene	protein-coding
	Description	60S ribosomal protein L38large ribosomal subunit protein eL38
	Modification date	20200313
	UniProtAcc	P63173

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPL38	GO:0002181	cytoplasmic translation	25957688

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL38	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL38[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL38	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000311111	72200056	72200097	5CDS-5UTR
ENST00000311111	72200268	72200329	Frame-shift
ENST00000439590	72200268	72200329	Frame-shift
ENST00000533498	72200268	72200329	Frame-shift
ENST00000311111	72205325	72205448	In-frame
ENST00000439590	72205325	72205448	In-frame
ENST00000533498	72205325	72205448	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000439590	72205325	72205448	448	232	354	70	21	62
ENST00000533498	72205325	72205448	549	317	439	70	21	62
ENST00000311111	72205325	72205448	1187	196	318	70	21	62

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P63173	21	62	1	70	Chain	ID=PRO_0000215434;Note=60S ribosomal protein L38
P63173	21	62	1	70	Chain	ID=PRO_0000215434;Note=60S ribosomal protein L38
P63173	21	62	1	70	Chain	ID=PRO_0000215434;Note=60S ribosomal protein L38

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	RPL38	-1.66722943744988	0.000257795914027732
LUSC	RPL38	-2.00110253296947	0.00049723236196648
PRAD	RPL38	-1.37307294389303	0.0319785302138518
KIRC	RPL38	-2.47198269993031	2.66680331214666e-11
KIRP	RPL38	-2.05925877790715	4.97791916131974e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KIRC	RPL38	-0.040906223	0.031078655
TGCT	RPL38	0.068377397	0.046107459

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL38 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CESC	Cell metabolism gene	RPL38	NME2	0.835514807	1.44E-81
CESC	TF	RPL38	NME2	0.835514807	1.44E-81
CHOL	Cell metabolism gene	RPL38	TOMM7	0.804173105	2.87E-11
CHOL	Cell metabolism gene	RPL38	SNRPD2	0.8158567	8.66E-12
CHOL	CGC	RPL38	NACA	0.844651844	3.04E-13
CHOL	TSG	RPL38	GNB2L1	0.821640728	4.64E-12
COAD	Cell metabolism gene	RPL38	NME2	0.808064363	3.86E-77
COAD	TF	RPL38	NME2	0.808064363	3.86E-77
DLBC	Cell metabolism gene	RPL38	PTDSS2	0.80057844	8.49E-12
DLBC	Cell metabolism gene	RPL38	TOMM7	0.802116299	7.24E-12
DLBC	Cell metabolism gene	RPL38	TBCA	0.804477801	5.64E-12
DLBC	Cell metabolism gene	RPL38	PSMD13	0.805863732	4.87E-12
DLBC	Cell metabolism gene	RPL38	DGUOK	0.808669752	3.60E-12
DLBC	Cell metabolism gene	RPL38	POLR2J	0.818921979	1.14E-12
DLBC	Cell metabolism gene	RPL38	POLR2L	0.821901624	8.06E-13
DLBC	Cell metabolism gene	RPL38	DPM2	0.823352657	6.79E-13
DLBC	Cell metabolism gene	RPL38	GEMIN7	0.82609257	4.89E-13
DLBC	Cell metabolism gene	RPL38	TIMM13	0.831565971	2.50E-13
DLBC	Cell metabolism gene	RPL38	PSMC5	0.832394734	2.25E-13
DLBC	Cell metabolism gene	RPL38	PGLS	0.834145036	1.80E-13
DLBC	Cell metabolism gene	RPL38	POLR2I	0.846079377	3.71E-14
DLBC	Cell metabolism gene	RPL38	POLR2F	0.847556553	3.02E-14
DLBC	Cell metabolism gene	RPL38	PSMB3	0.852999178	1.39E-14
DLBC	Cell metabolism gene	RPL38	GFER	0.85373115	1.25E-14
DLBC	Cell metabolism gene	RPL38	TOMM22	0.857102121	7.60E-15
DLBC	Cell metabolism gene	RPL38	PFDN4	0.860890824	4.27E-15
DLBC	Cell metabolism gene	RPL38	TIMM9	0.869170056	1.14E-15
DLBC	Cell metabolism gene	RPL38	FAU	0.885559299	6.32E-17
DLBC	Cell metabolism gene	RPL38	SNRPD2	0.89645328	7.15E-18
DLBC	Cell metabolism gene	RPL38	PFDN5	0.899213461	3.96E-18
DLBC	Cell metabolism gene	RPL38	NME2	0.901766464	2.26E-18
DLBC	CGC	RPL38	HRAS	0.807398432	4.13E-12
DLBC	CGC	RPL38	NACA	0.85446573	1.12E-14
DLBC	Epifactor	RPL38	MBD3	0.800147792	8.88E-12
DLBC	Epifactor	RPL38	ZNHIT1	0.805465831	5.08E-12
DLBC	Epifactor	RPL38	TAF10	0.817783009	1.30E-12
DLBC	Epifactor	RPL38	FBL	0.81984334	1.03E-12
DLBC	IUPHAR	RPL38	MMP24	0.805826158	4.89E-12
DLBC	IUPHAR	RPL38	HRAS	0.807398432	4.13E-12
DLBC	IUPHAR	RPL38	SIRT3	0.815403025	1.71E-12
DLBC	IUPHAR	RPL38	SLC25A39	0.828546235	3.63E-13
DLBC	TF	RPL38	MBD3	0.800147792	8.88E-12
DLBC	TF	RPL38	THAP3	0.820656322	9.33E-13
DLBC	TF	RPL38	ZNF444	0.826454844	4.68E-13
DLBC	TF	RPL38	THAP7	0.831623873	2.48E-13
DLBC	TF	RPL38	THAP4	0.864170421	2.56E-15
DLBC	TF	RPL38	NME2	0.901766464	2.26E-18
DLBC	TSG	RPL38	PHB	0.802013589	7.31E-12
DLBC	TSG	RPL38	SIRT3	0.815403025	1.71E-12
DLBC	TSG	RPL38	TSSC4	0.821948852	8.02E-13
DLBC	TSG	RPL38	PARK7	0.85567226	9.40E-15
DLBC	TSG	RPL38	GNB2L1	0.88793124	4.01E-17
DLBC	TSG	RPL38	GADD45GIP1	0.899450218	3.76E-18
GBM	Cell metabolism gene	RPL38	PSMB4	0.800626305	1.16E-39
GBM	Cell metabolism gene	RPL38	SSR4	0.804122892	3.02E-40
GBM	Cell metabolism gene	RPL38	PFDN5	0.8141525	5.49E-42
GBM	Cell metabolism gene	RPL38	FAU	0.832447385	1.88E-45
GBM	TSG	RPL38	GAS5	0.816533091	2.05E-42
HNSC	Cell metabolism gene	RPL38	NME2	0.84706075	6.02E-157
HNSC	TF	RPL38	NME2	0.84706075	6.02E-157
KICH	TSG	RPL38	GAS5	0.830061595	2.71E-24
KIRP	Cell metabolism gene	RPL38	NME1	0.802849963	4.36E-74
KIRP	Cell metabolism gene	RPL38	PFDN5	0.816499554	1.43E-78
KIRP	Cell metabolism gene	RPL38	FAU	0.822652464	1.03E-80
KIRP	Cell metabolism gene	RPL38	PSMB3	0.849806346	2.79E-91
KIRP	Cell metabolism gene	RPL38	NME2	0.862610235	5.11E-97
KIRP	Cell metabolism gene	RPL38	SNRPD2	0.879958949	8.64E-106
KIRP	TF	RPL38	NME2	0.862610235	5.11E-97
KIRP	TSG	RPL38	NME1	0.802849963	4.36E-74
LGG	Cell metabolism gene	RPL38	PFDN5	0.80388536	3.14E-121
LGG	Cell metabolism gene	RPL38	FAU	0.84252816	5.56E-144
LIHC	Cell metabolism gene	RPL38	PFDN5	0.835975782	8.89E-112
MESO	Cell metabolism gene	RPL38	FAU	0.832560231	1.61E-23
PCPG	Cell metabolism gene	RPL38	PFDN5	0.858559199	1.45E-55
PRAD	Cell metabolism gene	RPL38	SNRPF	0.813385983	4.86E-131
PRAD	Cell metabolism gene	RPL38	SNRPE	0.815072374	5.20E-132
PRAD	Cell metabolism gene	RPL38	TIMM9	0.834657257	4.59E-144
PRAD	Cell metabolism gene	RPL38	POLR2I	0.839283251	3.82E-147
PRAD	Cell metabolism gene	RPL38	POLR2F	0.841497552	1.19E-148
PRAD	Cell metabolism gene	RPL38	PSMB7	0.84257431	2.15E-149
PRAD	Cell metabolism gene	RPL38	NME2	0.843787016	3.08E-150
PRAD	Cell metabolism gene	RPL38	TOMM7	0.851506667	8.94E-156
PRAD	Cell metabolism gene	RPL38	FAU	0.873588085	1.56E-173
PRAD	Cell metabolism gene	RPL38	SNRPD2	0.893596647	8.78E-193
PRAD	CGC	RPL38	NACA	0.856214885	2.61E-159
PRAD	Epifactor	RPL38	FBL	0.862981166	1.29E-164
PRAD	TF	RPL38	NME2	0.843787016	3.08E-150
PRAD	TSG	RPL38	PDCD5	0.806276364	4.70E-127
PRAD	TSG	RPL38	GAS5	0.819715231	9.82E-135
PRAD	TSG	RPL38	GNB2L1	0.832211245	1.79E-142
TGCT	Cell metabolism gene	RPL38	SNRPD2	0.813982392	3.68E-38
TGCT	Cell metabolism gene	RPL38	POLR2I	0.828213033	1.44E-40
TGCT	Epifactor	RPL38	FBL	0.828898201	1.09E-40
THCA	Cell metabolism gene	RPL38	PSMB7	0.801729617	1.62E-129
THCA	Cell metabolism gene	RPL38	POLR2I	0.839684517	2.95E-153
THCA	Cell metabolism gene	RPL38	FAU	0.861911064	2.96E-170
THCA	Cell metabolism gene	RPL38	SNRPD2	0.878943881	1.98E-185
THCA	Cell metabolism gene	RPL38	PFDN5	0.880064278	1.65E-186
THCA	Epifactor	RPL38	FBL	0.805288479	1.62E-131
THCA	Epifactor	RPL38	TAF10	0.812783528	7.25E-136
THCA	IUPHAR	RPL38	CSNK2B	0.831580764	1.07E-147
THCA	TSG	RPL38	GABARAP	0.805726362	9.14E-132
THCA	TSG	RPL38	GADD45GIP1	0.81375989	1.90E-136
THCA	TSG	RPL38	GNB2L1	0.822515209	8.14E-142
THYM	Cell metabolism gene	RPL38	PTGES2	0.801352336	1.50E-28
THYM	Cell metabolism gene	RPL38	ATP5G1	0.801676071	1.38E-28
THYM	Cell metabolism gene	RPL38	LSM2	0.80186855	1.31E-28
THYM	Cell metabolism gene	RPL38	MMAB	0.802128634	1.22E-28
THYM	Cell metabolism gene	RPL38	NME2	0.802902756	9.86E-29
THYM	Cell metabolism gene	RPL38	SMPD2	0.803637798	8.07E-29
THYM	Cell metabolism gene	RPL38	PSME2	0.803666985	8.01E-29
THYM	Cell metabolism gene	RPL38	IMPDH2	0.804371896	6.60E-29
THYM	Cell metabolism gene	RPL38	POLR2F	0.805999663	4.21E-29
THYM	Cell metabolism gene	RPL38	EBP	0.807338476	2.90E-29
THYM	Cell metabolism gene	RPL38	PSMD4	0.807800689	2.55E-29
THYM	Cell metabolism gene	RPL38	MVD	0.807915985	2.47E-29
THYM	Cell metabolism gene	RPL38	PSMC1	0.808243295	2.25E-29
THYM	Cell metabolism gene	RPL38	PMPCA	0.810842202	1.08E-29
THYM	Cell metabolism gene	RPL38	POLD4	0.811200736	9.74E-30
THYM	Cell metabolism gene	RPL38	HMBS	0.811238192	9.63E-30
THYM	Cell metabolism gene	RPL38	GEMIN6	0.812461495	6.78E-30
THYM	Cell metabolism gene	RPL38	PHKG2	0.813593514	4.89E-30
THYM	Cell metabolism gene	RPL38	ALG3	0.814017577	4.32E-30
THYM	Cell metabolism gene	RPL38	ITPA	0.81449831	3.76E-30
THYM	Cell metabolism gene	RPL38	GEMIN7	0.815180245	3.08E-30
THYM	Cell metabolism gene	RPL38	EXOSC5	0.815196537	3.06E-30
THYM	Cell metabolism gene	RPL38	PSMD13	0.815647959	2.69E-30
THYM	Cell metabolism gene	RPL38	PSMB1	0.819916223	7.54E-31
THYM	Cell metabolism gene	RPL38	NT5C	0.821102343	5.27E-31
THYM	Cell metabolism gene	RPL38	PSMC3	0.822507915	3.43E-31
THYM	Cell metabolism gene	RPL38	DPM3	0.823240929	2.74E-31
THYM	Cell metabolism gene	RPL38	LCMT1	0.828609647	5.10E-32
THYM	Cell metabolism gene	RPL38	SNRPD3	0.831214593	2.21E-32
THYM	Cell metabolism gene	RPL38	POLR2J	0.83151857	2.00E-32
THYM	Cell metabolism gene	RPL38	GMPPA	0.832972443	1.25E-32
THYM	Cell metabolism gene	RPL38	ACOT8	0.842847464	4.39E-34
THYM	Cell metabolism gene	RPL38	MTX1	0.843552643	3.43E-34
THYM	Cell metabolism gene	RPL38	GFER	0.851363395	2.03E-35
THYM	Cell metabolism gene	RPL38	APRT	0.853355083	9.61E-36
THYM	Cell metabolism gene	RPL38	EXOSC4	0.853727613	8.34E-36
THYM	Cell metabolism gene	RPL38	TIMM10	0.858059554	1.57E-36
THYM	Cell metabolism gene	RPL38	PGLS	0.860483965	6.03E-37
THYM	Cell metabolism gene	RPL38	POLR2H	0.86225595	2.96E-37
THYM	Cell metabolism gene	RPL38	POLR2I	0.864498358	1.19E-37
THYM	Cell metabolism gene	RPL38	PSMB7	0.868542357	2.18E-38
THYM	Cell metabolism gene	RPL38	SLC27A5	0.868857158	1.91E-38
THYM	Cell metabolism gene	RPL38	PSMC5	0.869511983	1.44E-38
THYM	Cell metabolism gene	RPL38	TIMM13	0.873612821	2.41E-39
THYM	Cell metabolism gene	RPL38	SSR2	0.874816484	1.41E-39
THYM	Cell metabolism gene	RPL38	TIMM50	0.878498875	2.63E-40
THYM	Cell metabolism gene	RPL38	PSMB3	0.885062173	1.15E-41
THYM	Cell metabolism gene	RPL38	DPM2	0.885089262	1.14E-41
THYM	Cell metabolism gene	RPL38	TIMM8B	0.894047186	1.15E-43
THYM	Cell metabolism gene	RPL38	SNRPD2	0.898267737	1.14E-44
THYM	Cell metabolism gene	RPL38	FAU	0.919065212	2.35E-50
THYM	Cell metabolism gene	RPL38	PFDN5	0.929128299	1.10E-53
THYM	CGC	RPL38	RBM10	0.801769851	1.34E-28
THYM	CGC	RPL38	SDHAF2	0.804880918	5.74E-29
THYM	CGC	RPL38	TFPT	0.813394628	5.18E-30
THYM	CGC	RPL38	ASPSCR1	0.850782074	2.52E-35
THYM	Epifactor	RPL38	MBD3	0.803564267	8.23E-29
THYM	Epifactor	RPL38	PPP4C	0.810764112	1.10E-29
THYM	Epifactor	RPL38	TFPT	0.813394628	5.18E-30
THYM	Epifactor	RPL38	CCDC101	0.814050534	4.28E-30
THYM	Epifactor	RPL38	EXOSC5	0.815196537	3.06E-30
THYM	Epifactor	RPL38	C17orf49	0.82318426	2.79E-31
THYM	Epifactor	RPL38	NOC2L	0.834590464	7.32E-33
THYM	Epifactor	RPL38	INO80E	0.841958554	5.99E-34
THYM	Epifactor	RPL38	EXOSC4	0.853727613	8.34E-36
THYM	Epifactor	RPL38	PRPF31	0.859007067	1.08E-36
THYM	Epifactor	RPL38	ZNHIT1	0.86042516	6.18E-37
THYM	Epifactor	RPL38	SIRT6	0.882720476	3.59E-41
THYM	Epifactor	RPL38	TAF10	0.885656337	8.58E-42
THYM	Epifactor	RPL38	BRMS1	0.891373377	4.71E-43
THYM	Epifactor	RPL38	FBL	0.896384885	3.23E-44
THYM	IUPHAR	RPL38	PTGES2	0.801352336	1.50E-28
THYM	IUPHAR	RPL38	SMPD2	0.803637798	8.07E-29
THYM	IUPHAR	RPL38	IMPDH2	0.804371896	6.60E-29
THYM	IUPHAR	RPL38	MVD	0.807915985	2.47E-29
THYM	IUPHAR	RPL38	PHKG2	0.813593514	4.89E-30
THYM	IUPHAR	RPL38	PSMB1	0.819916223	7.54E-31
THYM	IUPHAR	RPL38	NT5C	0.821102343	5.27E-31
THYM	IUPHAR	RPL38	SIRT3	0.86169714	3.71E-37
THYM	IUPHAR	RPL38	SLC27A5	0.868857158	1.91E-38
THYM	IUPHAR	RPL38	SIRT6	0.882720476	3.59E-41
THYM	Kinase	RPL38	PHKG2	0.813593514	4.89E-30
THYM	TF	RPL38	ZBTB48	0.801318904	1.52E-28
THYM	TF	RPL38	NME2	0.802902756	9.86E-29
THYM	TF	RPL38	MBD3	0.803564267	8.23E-29
THYM	TF	RPL38	ZNF688	0.804907531	5.70E-29
THYM	TF	RPL38	THAP3	0.80900785	1.82E-29
THYM	TF	RPL38	ZNF428	0.81039249	1.23E-29
THYM	TF	RPL38	ZNF32	0.816004012	2.42E-30
THYM	TF	RPL38	ZNF524	0.82460745	1.80E-31
THYM	TF	RPL38	THAP7	0.837142416	3.12E-33
THYM	TF	RPL38	REXO4	0.85320594	1.02E-35
THYM	TF	RPL38	ZNF581	0.865876969	6.70E-38
THYM	TF	RPL38	ZNF787	0.867505162	3.39E-38
THYM	TSG	RPL38	ZBTB48	0.801318904	1.52E-28
THYM	TSG	RPL38	GLTSCR2	0.807506987	2.77E-29
THYM	TSG	RPL38	PHB	0.810698037	1.12E-29
THYM	TSG	RPL38	GABARAP	0.814843774	3.40E-30
THYM	TSG	RPL38	NPRL2	0.84290416	4.31E-34
THYM	TSG	RPL38	GNB2L1	0.85557675	4.12E-36
THYM	TSG	RPL38	SIRT3	0.86169714	3.71E-37
THYM	TSG	RPL38	TSSC4	0.875208332	1.18E-39
THYM	TSG	RPL38	SIRT6	0.882720476	3.59E-41
THYM	TSG	RPL38	BRMS1	0.891373377	4.71E-43
THYM	TSG	RPL38	GADD45GIP1	0.903008478	7.51E-46
UCEC	Cell metabolism gene	RPL38	FAU	0.801642485	2.41E-46
UCEC	Cell metabolism gene	RPL38	PFDN5	0.835899316	9.67E-54
UCS	Cell metabolism gene	RPL38	PTGES2	0.801352336	1.50E-28
UCS	Cell metabolism gene	RPL38	ATP5G1	0.801676071	1.38E-28
UCS	Cell metabolism gene	RPL38	LSM2	0.80186855	1.31E-28
UCS	Cell metabolism gene	RPL38	MMAB	0.802128634	1.22E-28
UCS	Cell metabolism gene	RPL38	NME2	0.802902756	9.86E-29
UCS	Cell metabolism gene	RPL38	SMPD2	0.803637798	8.07E-29
UCS	Cell metabolism gene	RPL38	PSME2	0.803666985	8.01E-29
UCS	Cell metabolism gene	RPL38	IMPDH2	0.804371896	6.60E-29
UCS	Cell metabolism gene	RPL38	POLR2F	0.805999663	4.21E-29
UCS	Cell metabolism gene	RPL38	EBP	0.807338476	2.90E-29
UCS	Cell metabolism gene	RPL38	PSMD4	0.807800689	2.55E-29
UCS	Cell metabolism gene	RPL38	MVD	0.807915985	2.47E-29
UCS	Cell metabolism gene	RPL38	PSMC1	0.808243295	2.25E-29
UCS	Cell metabolism gene	RPL38	PMPCA	0.810842202	1.08E-29
UCS	Cell metabolism gene	RPL38	POLD4	0.811200736	9.74E-30
UCS	Cell metabolism gene	RPL38	HMBS	0.811238192	9.63E-30
UCS	Cell metabolism gene	RPL38	GEMIN6	0.812461495	6.78E-30
UCS	Cell metabolism gene	RPL38	PHKG2	0.813593514	4.89E-30
UCS	Cell metabolism gene	RPL38	ALG3	0.814017577	4.32E-30
UCS	Cell metabolism gene	RPL38	ITPA	0.81449831	3.76E-30
UCS	Cell metabolism gene	RPL38	GEMIN7	0.815180245	3.08E-30
UCS	Cell metabolism gene	RPL38	EXOSC5	0.815196537	3.06E-30
UCS	Cell metabolism gene	RPL38	PSMD13	0.815647959	2.69E-30
UCS	Cell metabolism gene	RPL38	PSMB1	0.819916223	7.54E-31
UCS	Cell metabolism gene	RPL38	NT5C	0.821102343	5.27E-31
UCS	Cell metabolism gene	RPL38	PSMC3	0.822507915	3.43E-31
UCS	Cell metabolism gene	RPL38	DPM3	0.823240929	2.74E-31
UCS	Cell metabolism gene	RPL38	LCMT1	0.828609647	5.10E-32
UCS	Cell metabolism gene	RPL38	SNRPD3	0.831214593	2.21E-32
UCS	Cell metabolism gene	RPL38	POLR2J	0.83151857	2.00E-32
UCS	Cell metabolism gene	RPL38	GMPPA	0.832972443	1.25E-32
UCS	Cell metabolism gene	RPL38	ACOT8	0.842847464	4.39E-34
UCS	Cell metabolism gene	RPL38	MTX1	0.843552643	3.43E-34
UCS	Cell metabolism gene	RPL38	GFER	0.851363395	2.03E-35
UCS	Cell metabolism gene	RPL38	APRT	0.853355083	9.61E-36
UCS	Cell metabolism gene	RPL38	EXOSC4	0.853727613	8.34E-36
UCS	Cell metabolism gene	RPL38	TIMM10	0.858059554	1.57E-36
UCS	Cell metabolism gene	RPL38	PGLS	0.860483965	6.03E-37
UCS	Cell metabolism gene	RPL38	POLR2H	0.86225595	2.96E-37
UCS	Cell metabolism gene	RPL38	POLR2I	0.864498358	1.19E-37
UCS	Cell metabolism gene	RPL38	PSMB7	0.868542357	2.18E-38
UCS	Cell metabolism gene	RPL38	SLC27A5	0.868857158	1.91E-38
UCS	Cell metabolism gene	RPL38	PSMC5	0.869511983	1.44E-38
UCS	Cell metabolism gene	RPL38	TIMM13	0.873612821	2.41E-39
UCS	Cell metabolism gene	RPL38	SSR2	0.874816484	1.41E-39
UCS	Cell metabolism gene	RPL38	TIMM50	0.878498875	2.63E-40
UCS	Cell metabolism gene	RPL38	PSMB3	0.885062173	1.15E-41
UCS	Cell metabolism gene	RPL38	DPM2	0.885089262	1.14E-41
UCS	Cell metabolism gene	RPL38	TIMM8B	0.894047186	1.15E-43
UCS	Cell metabolism gene	RPL38	SNRPD2	0.898267737	1.14E-44
UCS	Cell metabolism gene	RPL38	FAU	0.919065212	2.35E-50
UCS	Cell metabolism gene	RPL38	PFDN5	0.929128299	1.10E-53
UCS	CGC	RPL38	RBM10	0.801769851	1.34E-28
UCS	CGC	RPL38	SDHAF2	0.804880918	5.74E-29
UCS	CGC	RPL38	TFPT	0.813394628	5.18E-30
UCS	CGC	RPL38	ASPSCR1	0.850782074	2.52E-35
UCS	Epifactor	RPL38	MBD3	0.803564267	8.23E-29
UCS	Epifactor	RPL38	PPP4C	0.810764112	1.10E-29
UCS	Epifactor	RPL38	TFPT	0.813394628	5.18E-30
UCS	Epifactor	RPL38	CCDC101	0.814050534	4.28E-30
UCS	Epifactor	RPL38	EXOSC5	0.815196537	3.06E-30
UCS	Epifactor	RPL38	C17orf49	0.82318426	2.79E-31
UCS	Epifactor	RPL38	NOC2L	0.834590464	7.32E-33
UCS	Epifactor	RPL38	INO80E	0.841958554	5.99E-34
UCS	Epifactor	RPL38	EXOSC4	0.853727613	8.34E-36
UCS	Epifactor	RPL38	PRPF31	0.859007067	1.08E-36
UCS	Epifactor	RPL38	ZNHIT1	0.86042516	6.18E-37
UCS	Epifactor	RPL38	SIRT6	0.882720476	3.59E-41
UCS	Epifactor	RPL38	TAF10	0.885656337	8.58E-42
UCS	Epifactor	RPL38	BRMS1	0.891373377	4.71E-43
UCS	Epifactor	RPL38	FBL	0.896384885	3.23E-44
UCS	IUPHAR	RPL38	PTGES2	0.801352336	1.50E-28
UCS	IUPHAR	RPL38	SMPD2	0.803637798	8.07E-29
UCS	IUPHAR	RPL38	IMPDH2	0.804371896	6.60E-29
UCS	IUPHAR	RPL38	MVD	0.807915985	2.47E-29
UCS	IUPHAR	RPL38	PHKG2	0.813593514	4.89E-30
UCS	IUPHAR	RPL38	PSMB1	0.819916223	7.54E-31
UCS	IUPHAR	RPL38	NT5C	0.821102343	5.27E-31
UCS	IUPHAR	RPL38	SIRT3	0.86169714	3.71E-37
UCS	IUPHAR	RPL38	SLC27A5	0.868857158	1.91E-38
UCS	IUPHAR	RPL38	SIRT6	0.882720476	3.59E-41
UCS	Kinase	RPL38	PHKG2	0.813593514	4.89E-30
UCS	TF	RPL38	ZBTB48	0.801318904	1.52E-28
UCS	TF	RPL38	NME2	0.802902756	9.86E-29
UCS	TF	RPL38	MBD3	0.803564267	8.23E-29
UCS	TF	RPL38	ZNF688	0.804907531	5.70E-29
UCS	TF	RPL38	THAP3	0.80900785	1.82E-29
UCS	TF	RPL38	ZNF428	0.81039249	1.23E-29
UCS	TF	RPL38	ZNF32	0.816004012	2.42E-30
UCS	TF	RPL38	ZNF524	0.82460745	1.80E-31
UCS	TF	RPL38	THAP7	0.837142416	3.12E-33
UCS	TF	RPL38	REXO4	0.85320594	1.02E-35
UCS	TF	RPL38	ZNF581	0.865876969	6.70E-38
UCS	TF	RPL38	ZNF787	0.867505162	3.39E-38
UCS	TSG	RPL38	ZBTB48	0.801318904	1.52E-28
UCS	TSG	RPL38	GLTSCR2	0.807506987	2.77E-29
UCS	TSG	RPL38	PHB	0.810698037	1.12E-29
UCS	TSG	RPL38	GABARAP	0.814843774	3.40E-30
UCS	TSG	RPL38	NPRL2	0.84290416	4.31E-34
UCS	TSG	RPL38	GNB2L1	0.85557675	4.12E-36
UCS	TSG	RPL38	SIRT3	0.86169714	3.71E-37
UCS	TSG	RPL38	TSSC4	0.875208332	1.18E-39
UCS	TSG	RPL38	SIRT6	0.882720476	3.59E-41
UCS	TSG	RPL38	BRMS1	0.891373377	4.71E-43
UCS	TSG	RPL38	GADD45GIP1	0.903008478	7.51E-46
UVM	Cell metabolism gene	RPL38	SSR2	0.815133466	3.51E-20
UVM	Cell metabolism gene	RPL38	FAU	0.861630286	1.11E-24
UVM	CGC	RPL38	NACA	0.828684925	2.37E-21
UVM	Epifactor	RPL38	FBL	0.873801201	3.88E-26
UVM	TSG	RPL38	GNB2L1	0.85902428	2.17E-24
UVM	TSG	RPL38	GLTSCR2	0.861823402	1.05E-24

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL38	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL38	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL38	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL38	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL38	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL38	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL38	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL38	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL38	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL38	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL38	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL38	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL38	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL38	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL38	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL38	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL38	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL38	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL38	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL38	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL38	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL38	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL38	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL38	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL38	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL38	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL38	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL38	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL38

TFE3, RIPK2, NME2, RUVBL2, MEPCE, AGO4, DCC, SIRT7, CUL3, CUL4A, CUL5, CUL2, CUL1, COPS5, COPS6, CAND1, CHMP5, RPS6, RPS12, RPS28, RPL23A, RPS15A, RPS19, RPS25, RPL5, RPL14, RPL8, RPL30, RPL3, RPL7, RPS13, RPS2, RPL36, RPL18, RPL10, RPL11, RPL35, RPL7A, RPL21, RPL17, RPL29, SRPRB, RPL10L, NDUFA7, NDUFA2, SLIRP, MRPL53, RBMS1, DUT, RRBP1, VCAM1, UBL4A, ITGA4, PAN2, AP2M1, EHD4, HNRNPA1, IARS, IGF2BP3, NMT1, PLCG1, RIC8A, ZC3HC1, ASB3, ASB10, ASB12, AURKA, CEP57, HAUS2, CEP76, LGALS3BP, NEDD1, TUBGCP4, RNF2, EGFR, EEF1G, PES1, RPL10A, RPL13, RPL13A, RPL15, RPL19, RPL22, RPL26, RPL27, RPL27A, RPL34, RPL37A, RPL12, RPL18A, RPL23, RPL24, RPL28, RPL31, RPL6, RPL9, RPS10, RPS11, RPS16, RPS20, RPS3, RPS3A, RPS5, RPS8, RPS9, RPSA, SLC1A2, RPL4, RPLP0, RPLP1, RPLP2, RPS14, RPS18, RPS23, LOC101929876, RPS26, RPS27, RPS4X, RPS7, SFN, PTEN, AHSA1, NPM1, SOX17, Eif3a, Eif3e, Prpf3, Rrbp1, MCM2, NANOG, POU5F1, RC3H1, MRPL34, TRIM25, HBP1, PPEF1, TGFB1, PRPF8, AAR2, PIH1D1, EFTUD2, RNF31, SPDL1, RIOK1, ESR2, HEXIM1, LARP7, AGR2, RECQL4, REST, MYC, Prkaa1, METTL3, KIAA1429, RC3H2, PHB, NR2C2, PPP1CC, ATXN3, VRK1, HIST1H4A, PSMD14, Dppa3, ITFG1, MARCKS, BIRC3, STAU1, WWP2, PSEN1, BCCIP, LILRB3, PLEKHA4, YAP1, TFCP2, NGB, HCVgp1, ZC3H18, GRB10, MAP3K14, MAPK14, PDPK1, VAV1, M, nsp9, ORF8, ESR1, CHMP4B, ECT2, KIF14, MAD2L2, KIF20A, KIF23, PRC1, LDLR, INS, Apc2, RNF185, RBM39, FBP1, RIN3, SPOP, PARK2, UFL1, DDRGK1, FZR1, WDR5, SPRTN, BTF3, SLFN11, FSCN1, FBXW7, nsp16, nsp3, nsp4, nsp5, nsp6, nsp7, ORF3a, CCNF,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL38	SKCM	chr17	72205441	72205442	-	C	Frame_Shift_Ins	p.LP60fs	3
RPL38	UCS	chr17	72205359	72205359	A	C	Missense_Mutation	p.K33T	3
RPL38	STAD	chr17	72205355	72205355	G	A	Missense_Mutation	p.V32M	2
RPL38	UCEC	chr17	72205370	72205370	C	T	Nonsense_Mutation	p.R37*	2
RPL38	LIHC	chr17	72205442	72205442	C	-	Frame_Shift_Del	p.P62fs	1
RPL38	SARC	chr17	72200268	72200268	G	T	Splice_Site		1
RPL38	SKCM	chr17	72205447	72205447	C	T	Silent	p.P62P	1
RPL38	SKCM	chr17	72205447	72205447	C	T	Splice_Site	p.P62_splice	1
RPL38	UCS	chr17	72205359	72205359	A	C	Missense_Mutation		1
RPL38	COAD	chr17	72205348	72205348	G	A	Silent	p.K29K	1
RPL38	ESCA	chr17	72200319	72200319	G	-	Frame_Shift_Del	p.D19fs	1
RPL38	LIHC	chr17	72200308	72200308	G	T	Missense_Mutation		1

Copy number variation (CNV) of RPL38
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL38
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
100292	UCEC	TCGA-BK-A4ZD-01A	ARHGAP44	chr17	12707446	+	RPL38	chr17	72200328	-
100292	STAD	TCGA-CD-5813-01A	FAM174B	chr15	93173444	-	RPL38	chr17	72200057	+
100292	N/A	AA513068	LINC00348	chr13	71739987	+	RPL38	chr17	72206019	-
100292	N/A	CA313275	MNT	chr17	2287508	+	RPL38	chr17	72205995	-
100292	N/A	CK004088	NDRG2	chr14	21486161	-	RPL38	chr17	72200288	+
100292	STAD	TCGA-HU-A4GT-01A	NT5C2	chr10	104934615	-	RPL38	chr17	72205326	+
100292	N/A	BP431372	OPCML	chr11	132732378	-	RPL38	chr17	72199818	+
100292	N/A	BC046153	PMS2P3	chr7	75144011	-	RPL38	chr17	72205948	+
101632	LGG	TCGA-HT-7479	RPL38	chr17	72200329	+	BCAS3	chr17	58979980	+
101632	LGG	TCGA-HT-7479-01A	RPL38	chr17	72200329	+	BCAS3	chr17	58979981	+
76787	N/A	BE388615	RPL38	chr17	72206007	+	CITED1	chrX	71526691	-
92023	BRCA	TCGA-C8-A137-01A	RPL38	chr17	72200097	+	CNN2	chr19	1032558	+
102507	BLCA	TCGA-GU-A42Q-01A	RPL38	chr17	72206019	-	DDX21	chr10	70723858	+
95793	N/A	AA017134	RPL38	chr17	72205967	-	DST	chr6	56330941	-
101214	N/A	DA794650	RPL38	chr17	72205450	+	HSP90AA1	chr14	102553443	-
101776	BRCA	TCGA-LL-A6FR-01A	RPL38	chr17	72200329	+	KIF19	chr17	72324564	+
92655	N/A	BG575219	RPL38	chr17	72206019	+	LCOR	chr10	98729731	-
82170	N/A	BP430404	RPL38	chr17	72206019	+	LINC00348	chr13	71739987	-
76787	N/A	BG272139	RPL38	chr17	72200268	-	NABP1	chr2	192551145	+
76787	N/A	BM810069	RPL38	chr17	72199954	-	NCAPH2	chr22	50962352	+
100244	N/A	BP222381	RPL38	chr17	72205423	+	PHF20	chr20	34359946	+
99215	N/A	BF219484	RPL38	chr17	72206019	+	PSD3	chr8	18401129	+
101134	N/A	CD368190	RPL38	chr17	72205334	-	RPL3	chr22	39710181	+
100464	N/A	BF344361	RPL38	chr17	72206019	+	SLC24A2	chr9	20154647	+
85000	N/A	BF696633	RPL38	chr17	72199886	+	SNX3	chr6	108533458	-
100712	N/A	R50162	RPL38	chr17	72205325	-	TEK	chr9	27190586	-
95550	N/A	BP282584	RPL38	chr17	72206054	+	TMCO4	chr1	20036789	-
80051	N/A	AA977713	RPL38	chr17	72205963	-	TRAPPC6B	chr14	39619329	+
76787	N/A	CA432338	RPL38	chr17	72205967	-	TRMT5	chr14	61442204	+
95441	N/A	DB371044	RPL38	chr17	72205942	-	UBE2J2	chr1	1189857	+
100292	N/A	BI861689	SUPT7L	chr2	27876379	-	RPL38	chr17	72200077	+
100292	N/A	CR746137	SURF6	chr9	136199561	+	RPL38	chr17	72199817	+
100292	N/A	BX101889	TEK	chr9	27190586	+	RPL38	chr17	72205325	+
100292	N/A	AK075017	UBE2J2	chr1	1189857	-	RPL38	chr17	72205942	+
100292	N/A	N71857	ZBED5-AS1	chr11	10889559	+	RPL38	chr17	72206019	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	RPL38	0.0300258387018913	0.84
TGCT	RPL38	0.0320227990268592	0.86
KIRC	RPL38	0.0497289803788017	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL38	9.7368157734934e-05	0.0032
KIRC	RPL38	0.0256245619121309	0.77
GBM	RPL38	0.0273500098079783	0.79
LAML	RPL38	0.00378858063690837	0.12
BRCA	RPL38	0.00658255318103281	0.2
CHOL	RPL38	0.0344084321514592	0.96

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source