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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: RPL36A (NCBI Gene ID:6173)


Gene Summary

check button Gene Summary
Gene InformationGene Name: RPL36A
Gene ID: 6173
Gene Symbol

RPL36A

Gene ID

6173

Gene Nameribosomal protein L36a
SynonymsL36A|L44L|MIG6|RPL44
Cytomap

Xq22.1

Type of Geneprotein-coding
Description60S ribosomal protein L36a60S ribosomal protein L44L44-like ribosomal proteincell growth-inhibiting gene 15 proteincell migration-inducing gene 6 proteindJ164F3.3 (ribosomal protein L44)large ribosomal subunit protein eL42
Modification date20200313
UniProtAcc

P83881


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0005840Ribosome
GO:0002181Cytoplasmic translation
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPL36A

GO:0002181

cytoplasmic translation

25957688



check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL36A>1119.25


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Translation Studies in PubMed

check button We searched PubMed using 'RPL36A[title] AND translation [title] AND human.'
GeneTitlePMID
RPL36A..


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.


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Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
all structure

check buttonExpression level of gene isoforms across TCGA pancancer
all structure

check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
all structure

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
PRADRPL36A-1.220127010491820.000670334620795339
KICHRPL36A-2.277205222559540.00557881593704224
KIRPRPL36A-1.069753604986870.0099095250479877
LUADRPL36A-2.479215876028561.44981692033783e-08
LIHCRPL36A-1.756769832983992.98009622125841e-06


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a
MESORPL36A120.04383457320219940.03935013698630140.3358257142857140.1967514296709580.433916791706214

check buttonTranslation factor expression regulation through copy number variation of Translation factor
Cancer typeGeneCoefficientPvalue
THCARPL36A0.0315223360.011471718
CHOLRPL36A0.0306237170.011885982

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with RPL36A (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
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* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
PRADRPL36ARPL7A1.067438840700380.000154375047072011
BRCARPL36ARPL7A-3.091264649657340.000158086090138015
KIRPRPL36ARPL18A-1.516513928088850.00016188295558095
BLCARPL36ARPL10A-6.446578051406520.000164031982421875
LUSCRPL36ARPS21-3.866462958345540.000217448138016549
LUADRPL36ARPL38-1.667229437449880.000257795914027732
STADRPL36ARPS231.850767606645760.000364991836249828
LUSCRPL36ARPL38-2.001102532969470.00049723236196648
LIHCRPL36ARPL8-4.845882849745580.00110314154326131
BRCARPL36ARPL39-1.412196288481210.00163371967664225
COADRPL36ARPL7A2.303534942943970.00197160243988037
PRADRPL36ARPL18A1.406001757484990.00205137828390396
KICHRPL36ARPL191.369011828940890.00250792503356934
LUADRPL36ARPS21-2.063552090279840.00342681008979313
LUSCRPL36ARPL39-2.235439143030940.00457577784727754
KIRPRPL36ARPL7A-1.791566021339610.00647870777174831
ESCARPL36ARPS21-3.394372190113660.009765625
LUADRPL36ARPL19-1.313980266157250.00993159558412698
KICHRPL36ARPL10A1.571077903720510.0124664902687073
LUADRPL36ARPS26-1.301799811657250.0163893452361939
LUSCRPL36ARPS231.467511698910470.0174932185880974
PRADRPL36ARPL39-2.634483963050360.0291755363147523
PRADRPL36ARPL38-1.373072943893030.0319785302138518
THCARPL36ARPL39-1.215160434591160.0375744128896741
LUSCRPL36ARPL19-2.146698895166660.044366810398747
UCECRPL36ARPS23-2.036581598140070.046875
KIRCRPL36ARPL19-2.734852712766761.33980982873695e-10
THCARPL36ARPL7A2.290013837614441.71901813744324e-05
KIRCRPL36ARPL38-2.471982699930312.66680331214666e-11
KIRCRPL36ARPS21-1.22226515129064.25761914751048e-08
KIRPRPL36ARPL38-2.059258777907154.97791916131974e-07
KIRCRPL36ARPL7A-3.593487383988335.5547256801368e-06
KIRCRPL36ARPL10A-2.34550280902265.61779186490163e-09
KIRCRPL36ARPL8-1.182524599717735.64962994208288e-07
KIRPRPL36ARPL8-1.530036923501196.0301274061203e-05
KIRCRPL36ARPL18A-4.430793049608439.2516163152192e-11


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with RPL36A
MAGEB2, PSTPIP1, HDAC6, TCF3, ESR1, PAN2, SAV1, NAP1L1, HSPB2, IFI16, gag, HNRNPU, Srp72, Rrbp1, MDM2, CDH1, INO80B, ANAPC13, CAPZB, CEP152, CEP192, DCTN4, EXOSC9, GFI1B, GINS4, KIF14, MCM3AP, METAP2, ORAOV1, PAFAH1B1, PELO, POLA1, POLE, PPCS, RPA3, SLC7A1, SRSF7, TUBB, TUBGCP4, WDR70, FBXO7, PHACTR3, PYHIN1, RIOK1, HEXIM1, MEPCE, LARP7, RECQL4, REST, RPS6, HIST1H3A, AIFM1, RC3H1, RC3H2, ATG16L1, NR2C2, VRK1, HIST1H4A, DDX60, MICB, SNRNP70, ITFG1, BIRC3, STAU1, NFX1, WWP2, AIDA, NGB, HCVgp1, ORF50, ZC3H18, MAP3K14, PRKAR1A, SH3GL3, MAP1LC3B, NEK4, CHMP4C, KIF20A, MAFB, BRD4, Apc2, RBM39, FBP1, RIN3, DNAJC2, JMJD4, L3MBTL1, PARK2, PAGE4, NAA40, ZBTB2, SDAD1, PAGE2B, BTF3, KLF16, KLF5, KLF9, KLF15, KLF4, KLF8, TLX1,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo
RPL36AchrX100646774CTsingle_nucleotide_variantBenignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
RPL36ALUADchrX100646510100646510GAMissense_Mutationp.V59M3
RPL36ACHOLchrX100646777100646777TGNonsense_Mutationp.Y84*2
RPL36ASARCchrX100646802100646802CTMissense_Mutation2
RPL36ACHOLchrX100646777100646777TGNonsense_Mutation2
RPL36ASARCchrX100646748100646748CTMissense_Mutation2
RPL36ASARCchrX100646748100646748CTMissense_Mutationp.R75W2
RPL36ATHCAchrX100650727100650727CASilentp.I140I2
RPL36ASARCchrX100646802100646802CTMissense_Mutationp.R93W2
RPL36AUCECchrX100650475100650475TGSilentp.S1102
RPL36ASKCMchrX100645981100645981CTMissense_Mutationp.P20S2
RPL36ASTADchrX100646541100646541TAMissense_Mutation2
RPL36ASTADchrX100645994100645994GAMissense_Mutation2
RPL36ASTADchrX100646510100646510GAMissense_Mutation2
RPL36ACESCchrX100646524100646524GASilent1
RPL36ALUADchrX100646034100646034GAMissense_Mutationp.M1I1
RPL36ASTADchrX100645994100645994GAMissense_Mutationp.R24Q1
RPL36ASTADchrX100646445100646445AGSplice_Sitep.V2_splice1
RPL36ATHCAchrX100650727100650727CASilent1
RPL36AGBMchrX100646547100646547CTMissense_Mutation1
RPL36AGBMchrX100646453100646453GAMissense_Mutation1
RPL36AKIRPchrX100646010100646010CTSilent1
RPL36ALIHCchrX100650438100650438AGMissense_Mutation1
RPL36ALIHCchrX100646804100646805-AFrame_Shift_Insp.RK93fs1
RPL36ALIHCchrX100646797100646797T-Frame_Shift_Delp.I91fs1
RPL36ABLCAchrX100646014100646014GAMissense_Mutation1
RPL36ASTADchrX100646445100646445AGSplice_Site.1
RPL36ABLCAchrX100646014100646014GAMissense_Mutationp.D31N1
RPL36ALUADchrX100646034100646034GASplice_Sitep.M37_splice1
RPL36ASTADchrX100646541100646541TAMissense_Mutationp.L69Q1

check buttonCopy number variation (CNV) of RPL36A
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across RPL36A
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
87307GBMTCGA-06-2565-01ARPL36AchrX100646552+MEG3chr14101302073+
101593N/ABF219110RPL36AchrX100646034+RPL36A-HNRNPH2chrX100646447+


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples
THCARPL36A0.133055270517218-2.016990669286140.000825786883565560.000396959730429190.00158607434000179571
THCARPL36A0.133055270517218-2.016990669286140.000825786883565560.000396959730429190.00158607434000179571
READRPL36A2.921451572720681.072080606705420.01655680538115520.01946531112609070.0178298456116427103
MESORPL36A0.682020034684512-0.38269624519990.03596306778712470.03264734891034490.035719983450865585
MESORPL36A0.682020034684512-0.38269624519990.03596306778712470.03264734891034490.035719983450865585
LGGRPL36A0.418492640031418-0.8710959757510563.00218976039521e-061.73468068436305e-065.79624553900137e-06525


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
MESORPL36A0.006161446211819230.17
LUADRPL36A0.02639486243322090.71

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
PRADRPL36A0.01083073672293530.36
PAADRPL36A0.03187475361474791

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source
C0152013Adenocarcinoma of lung (disorder)1CTD_human