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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPLP0 (NCBI Gene ID:6175)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPLP0
	Gene ID: 6175
	Gene Symbol	RPLP0
	Gene ID	6175
	Gene Name	ribosomal protein lateral stalk subunit P0
	Synonyms	L10E\|LP0\|P0\|PRLP0\|RPP0
	Cytomap	12q24.23
	Type of Gene	protein-coding
	Description	60S acidic ribosomal protein P060S ribosomal protein L10Eacidic ribosomal phosphoprotein P0large ribosomal subunit protein uL10neutral ribosomal phosphoprotein P0ribosomal protein, large, P0
	Modification date	20200313
	UniProtAcc	P05388

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPLP0[title] AND translation [title] AND human.'

Gene	Title	PMID
RPLP0	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000228306	120635124	120635265	In-frame
ENST00000392514	120635124	120635265	In-frame
ENST00000551150	120635124	120635265	In-frame
ENST00000228306	120636356	120636542	In-frame
ENST00000392514	120636356	120636542	In-frame
ENST00000551150	120636356	120636542	In-frame
ENST00000228306	120636656	120636803	In-frame
ENST00000392514	120636656	120636803	In-frame
ENST00000551150	120636656	120636803	In-frame
ENST00000228306	120637112	120637288	Frame-shift
ENST00000392514	120637112	120637288	Frame-shift
ENST00000551150	120637112	120637288	Frame-shift
ENST00000228306	120638532	120638694	3UTR-3CDS

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000392514	120635124	120635265	1235	829	969	317	217	264
ENST00000228306	120635124	120635265	1274	889	1029	317	217	264
ENST00000551150	120635124	120635265	1361	968	1108	317	217	264
ENST00000392514	120636356	120636542	1235	643	828	317	155	217
ENST00000228306	120636356	120636542	1274	703	888	317	155	217
ENST00000551150	120636356	120636542	1361	782	967	317	155	217
ENST00000392514	120636656	120636803	1235	496	642	317	106	155
ENST00000228306	120636656	120636803	1274	556	702	317	106	155
ENST00000551150	120636656	120636803	1361	635	781	317	106	155

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P05388	106	155	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
P05388	155	217	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
P05388	217	264	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
P05388	106	155	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
P05388	155	217	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
P05388	217	264	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
P05388	106	155	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
P05388	155	217	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
P05388	217	264	1	317	Chain	ID=PRO_0000154758;Note=60S acidic ribosomal protein P0
P05388	155	217	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P05388	217	264	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P05388	155	217	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P05388	217	264	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P05388	155	217	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P05388	217	264	156	217	Alternative sequence	ID=VSP_055867;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P05388	217	264	246	246	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
P05388	217	264	246	246	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305
P05388	217	264	246	246	Sequence conflict	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
THCA	RPLP0	-1.74888680592094	0.000772056397653126
KICH	RPLP0	-1.2840132894761	0.00341922044754028
COAD	RPLP0	1.273203752387	0.011966735124588
KIRC	RPLP0	-3.51594265725619	1.68239022549371e-11
LUAD	RPLP0	-1.80912884665876	3.32622703073417e-05
KIRP	RPLP0	-2.44352164022892	5.8719888329506e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
UCEC	RPLP0	hsa-miR-382-5p	97	-0.377234530175707	0.0285537830365928

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LUAD	RPLP0	0.099381826	0.030671141

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPLP0 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	RPLP0	NME2	0.814689629	9.80E-12
CHOL	CGC	RPLP0	NACA	0.88089644	1.47E-15
CHOL	Epifactor	RPLP0	FBL	0.805770517	2.45E-11
CHOL	TF	RPLP0	NME2	0.814689629	9.80E-12
CHOL	TSG	RPLP0	GNB2L1	0.834874065	1.02E-12
DLBC	Cell metabolism gene	RPLP0	TIMM13	0.80056645	8.50E-12
DLBC	Cell metabolism gene	RPLP0	TOMM22	0.83158336	2.49E-13
DLBC	Cell metabolism gene	RPLP0	NME2	0.835857538	1.45E-13
DLBC	Cell metabolism gene	RPLP0	SNRPD2	0.842477954	6.06E-14
DLBC	Epifactor	RPLP0	PRMT1	0.808674044	3.60E-12
DLBC	Epifactor	RPLP0	FBL	0.855327647	9.89E-15
DLBC	IUPHAR	RPLP0	PRMT1	0.808674044	3.60E-12
DLBC	TF	RPLP0	NME2	0.835857538	1.45E-13
DLBC	TSG	RPLP0	GNB2L1	0.816900306	1.44E-12
GBM	Cell metabolism gene	RPLP0	SSR2	0.842362129	1.65E-47
GBM	TF	RPLP0	ZNF90	0.855147161	2.21E-50
GBM	TSG	RPLP0	GNB2L1	0.82388974	8.82E-44
LAML	Epifactor	RPLP0	FBL	0.800192158	8.17E-40
LGG	TSG	RPLP0	GNB2L1	0.8742089	8.51E-168
PRAD	Cell metabolism gene	RPLP0	TIMM9	0.815249967	4.11E-132
PRAD	Cell metabolism gene	RPLP0	NME2	0.825737669	2.18E-138
PRAD	CGC	RPLP0	NACA	0.837968131	2.94E-146
PRAD	Epifactor	RPLP0	FBL	0.813724764	3.11E-131
PRAD	TF	RPLP0	NME2	0.825737669	2.18E-138
PRAD	TF	RPLP0	ZNF581	0.826745643	5.17E-139
PRAD	TSG	RPLP0	GAS5	0.846136073	6.86E-152
PRAD	TSG	RPLP0	GNB2L1	0.898521665	4.08E-198
THCA	TSG	RPLP0	GNB2L1	0.834184935	1.89E-149
THYM	Cell metabolism gene	RPLP0	SNRPB	0.800183052	2.06E-28
THYM	Cell metabolism gene	RPLP0	LSM4	0.800630465	1.82E-28
THYM	Cell metabolism gene	RPLP0	PSMC5	0.80117533	1.58E-28
THYM	Cell metabolism gene	RPLP0	FPGS	0.802302581	1.16E-28
THYM	Cell metabolism gene	RPLP0	SNRPD1	0.804747246	5.95E-29
THYM	Cell metabolism gene	RPLP0	HMOX2	0.804790937	5.88E-29
THYM	Cell metabolism gene	RPLP0	DGKZ	0.807861551	2.51E-29
THYM	Cell metabolism gene	RPLP0	APRT	0.810780404	1.10E-29
THYM	Cell metabolism gene	RPLP0	PYCRL	0.811875488	8.03E-30
THYM	Cell metabolism gene	RPLP0	LSM2	0.812323696	7.06E-30
THYM	Cell metabolism gene	RPLP0	PSMD4	0.815488769	2.81E-30
THYM	Cell metabolism gene	RPLP0	DOHH	0.816164051	2.31E-30
THYM	Cell metabolism gene	RPLP0	ATP5G1	0.816445	2.12E-30
THYM	Cell metabolism gene	RPLP0	PSMD13	0.817451686	1.58E-30
THYM	Cell metabolism gene	RPLP0	PTGES2	0.81799613	1.34E-30
THYM	Cell metabolism gene	RPLP0	PSME1	0.819631285	8.22E-31
THYM	Cell metabolism gene	RPLP0	POLR2I	0.820892751	5.61E-31
THYM	Cell metabolism gene	RPLP0	DPM2	0.821449397	4.74E-31
THYM	Cell metabolism gene	RPLP0	TOMM40	0.827115036	8.20E-32
THYM	Cell metabolism gene	RPLP0	GMPPA	0.829550833	3.78E-32
THYM	Cell metabolism gene	RPLP0	MTX1	0.83046707	2.82E-32
THYM	Cell metabolism gene	RPLP0	TIMM10	0.832446816	1.48E-32
THYM	Cell metabolism gene	RPLP0	ALG3	0.833084357	1.20E-32
THYM	Cell metabolism gene	RPLP0	TOMM22	0.834826502	6.77E-33
THYM	Cell metabolism gene	RPLP0	NME2	0.836952062	3.33E-33
THYM	Cell metabolism gene	RPLP0	GEMIN6	0.83789793	2.42E-33
THYM	Cell metabolism gene	RPLP0	PGLS	0.838849037	1.75E-33
THYM	Cell metabolism gene	RPLP0	EBP	0.839641866	1.33E-33
THYM	Cell metabolism gene	RPLP0	NME1	0.840563634	9.72E-34
THYM	Cell metabolism gene	RPLP0	SNRPE	0.841129256	7.99E-34
THYM	Cell metabolism gene	RPLP0	PFDN5	0.842370693	5.19E-34
THYM	Cell metabolism gene	RPLP0	ACOT8	0.844524951	2.43E-34
THYM	Cell metabolism gene	RPLP0	DTYMK	0.844901769	2.13E-34
THYM	Cell metabolism gene	RPLP0	TALDO1	0.84531055	1.84E-34
THYM	Cell metabolism gene	RPLP0	PSMC3	0.845897128	1.49E-34
THYM	Cell metabolism gene	RPLP0	NOP56	0.846034714	1.42E-34
THYM	Cell metabolism gene	RPLP0	POLD2	0.846515787	1.20E-34
THYM	Cell metabolism gene	RPLP0	SRM	0.846952975	1.02E-34
THYM	Cell metabolism gene	RPLP0	SSR2	0.847869126	7.33E-35
THYM	Cell metabolism gene	RPLP0	ITPA	0.848840962	5.14E-35
THYM	Cell metabolism gene	RPLP0	GEMIN7	0.851960132	1.62E-35
THYM	Cell metabolism gene	RPLP0	IMPDH2	0.852169399	1.50E-35
THYM	Cell metabolism gene	RPLP0	TIMM50	0.852986211	1.10E-35
THYM	Cell metabolism gene	RPLP0	PSMB7	0.857368949	2.06E-36
THYM	Cell metabolism gene	RPLP0	NANS	0.858331191	1.41E-36
THYM	Cell metabolism gene	RPLP0	PSMB3	0.860269896	6.57E-37
THYM	Cell metabolism gene	RPLP0	FAU	0.865797653	6.92E-38
THYM	Cell metabolism gene	RPLP0	PMPCA	0.867137863	3.95E-38
THYM	Cell metabolism gene	RPLP0	POLR2H	0.871655686	5.70E-39
THYM	Cell metabolism gene	RPLP0	SLC27A5	0.88064827	9.63E-41
THYM	Cell metabolism gene	RPLP0	TIMM8B	0.887252073	3.88E-42
THYM	Cell metabolism gene	RPLP0	HMBS	0.889139433	1.49E-42
THYM	Cell metabolism gene	RPLP0	EXOSC4	0.889177222	1.46E-42
THYM	Cell metabolism gene	RPLP0	EXOSC5	0.889206763	1.44E-42
THYM	Cell metabolism gene	RPLP0	SNRPD2	0.89098574	5.77E-43
THYM	Cell metabolism gene	RPLP0	TIMM13	0.892227237	3.01E-43
THYM	CGC	RPLP0	ASPSCR1	0.801337544	1.51E-28
THYM	CGC	RPLP0	RBM10	0.801768912	1.34E-28
THYM	CGC	RPLP0	TFPT	0.806180695	4.01E-29
THYM	CGC	RPLP0	SDHAF2	0.852110573	1.53E-35
THYM	Epifactor	RPLP0	PPM1G	0.802301136	1.16E-28
THYM	Epifactor	RPLP0	TFPT	0.806180695	4.01E-29
THYM	Epifactor	RPLP0	LAS1L	0.813492967	5.03E-30
THYM	Epifactor	RPLP0	PPP4C	0.822340015	3.61E-31
THYM	Epifactor	RPLP0	MBD3	0.822829737	3.11E-31
THYM	Epifactor	RPLP0	C17orf49	0.824436271	1.89E-31
THYM	Epifactor	RPLP0	PRPF31	0.824806054	1.69E-31
THYM	Epifactor	RPLP0	RUVBL2	0.829581254	3.74E-32
THYM	Epifactor	RPLP0	RRP8	0.839930044	1.21E-33
THYM	Epifactor	RPLP0	SIRT6	0.855541232	4.18E-36
THYM	Epifactor	RPLP0	TAF10	0.85614162	3.31E-36
THYM	Epifactor	RPLP0	PRMT1	0.865118639	9.18E-38
THYM	Epifactor	RPLP0	BRMS1	0.872796935	3.46E-39
THYM	Epifactor	RPLP0	NOC2L	0.877077382	5.06E-40
THYM	Epifactor	RPLP0	EXOSC4	0.889177222	1.46E-42
THYM	Epifactor	RPLP0	EXOSC5	0.889206763	1.44E-42
THYM	Epifactor	RPLP0	FBL	0.931660393	1.34E-54
THYM	IUPHAR	RPLP0	HMOX2	0.804790937	5.88E-29
THYM	IUPHAR	RPLP0	FKBP1A	0.811319537	9.41E-30
THYM	IUPHAR	RPLP0	PTGES2	0.81799613	1.34E-30
THYM	IUPHAR	RPLP0	ECE2	0.822705795	3.23E-31
THYM	IUPHAR	RPLP0	MFSD2B	0.850735634	2.56E-35
THYM	IUPHAR	RPLP0	IMPDH2	0.852169399	1.50E-35
THYM	IUPHAR	RPLP0	SIRT6	0.855541232	4.18E-36
THYM	IUPHAR	RPLP0	PRMT1	0.865118639	9.18E-38
THYM	IUPHAR	RPLP0	SLC27A5	0.88064827	9.63E-41
THYM	TF	RPLP0	ZBTB48	0.822388874	3.56E-31
THYM	TF	RPLP0	MBD3	0.822829737	3.11E-31
THYM	TF	RPLP0	ZNF511	0.832740399	1.35E-32
THYM	TF	RPLP0	ZNF787	0.836049236	4.50E-33
THYM	TF	RPLP0	NME2	0.836952062	3.33E-33
THYM	TF	RPLP0	REXO4	0.850075183	3.27E-35
THYM	TF	RPLP0	ZNF581	0.886984879	4.43E-42
THYM	TSG	RPLP0	NPRL2	0.801012611	1.65E-28
THYM	TSG	RPLP0	GLTSCR2	0.807326297	2.91E-29
THYM	TSG	RPLP0	PHB	0.807782007	2.56E-29
THYM	TSG	RPLP0	ZBTB48	0.822388874	3.56E-31
THYM	TSG	RPLP0	GADD45GIP1	0.834915791	6.57E-33
THYM	TSG	RPLP0	GNB2L1	0.840561031	9.73E-34
THYM	TSG	RPLP0	NME1	0.840563634	9.72E-34
THYM	TSG	RPLP0	SIRT6	0.855541232	4.18E-36
THYM	TSG	RPLP0	TSSC4	0.863567562	1.74E-37
THYM	TSG	RPLP0	BRMS1	0.872796935	3.46E-39
UCS	Cell metabolism gene	RPLP0	SNRPB	0.800183052	2.06E-28
UCS	Cell metabolism gene	RPLP0	LSM4	0.800630465	1.82E-28
UCS	Cell metabolism gene	RPLP0	PSMC5	0.80117533	1.58E-28
UCS	Cell metabolism gene	RPLP0	FPGS	0.802302581	1.16E-28
UCS	Cell metabolism gene	RPLP0	SNRPD1	0.804747246	5.95E-29
UCS	Cell metabolism gene	RPLP0	HMOX2	0.804790937	5.88E-29
UCS	Cell metabolism gene	RPLP0	DGKZ	0.807861551	2.51E-29
UCS	Cell metabolism gene	RPLP0	APRT	0.810780404	1.10E-29
UCS	Cell metabolism gene	RPLP0	PYCRL	0.811875488	8.03E-30
UCS	Cell metabolism gene	RPLP0	LSM2	0.812323696	7.06E-30
UCS	Cell metabolism gene	RPLP0	PSMD4	0.815488769	2.81E-30
UCS	Cell metabolism gene	RPLP0	DOHH	0.816164051	2.31E-30
UCS	Cell metabolism gene	RPLP0	ATP5G1	0.816445	2.12E-30
UCS	Cell metabolism gene	RPLP0	PSMD13	0.817451686	1.58E-30
UCS	Cell metabolism gene	RPLP0	PTGES2	0.81799613	1.34E-30
UCS	Cell metabolism gene	RPLP0	PSME1	0.819631285	8.22E-31
UCS	Cell metabolism gene	RPLP0	POLR2I	0.820892751	5.61E-31
UCS	Cell metabolism gene	RPLP0	DPM2	0.821449397	4.74E-31
UCS	Cell metabolism gene	RPLP0	TOMM40	0.827115036	8.20E-32
UCS	Cell metabolism gene	RPLP0	GMPPA	0.829550833	3.78E-32
UCS	Cell metabolism gene	RPLP0	MTX1	0.83046707	2.82E-32
UCS	Cell metabolism gene	RPLP0	TIMM10	0.832446816	1.48E-32
UCS	Cell metabolism gene	RPLP0	ALG3	0.833084357	1.20E-32
UCS	Cell metabolism gene	RPLP0	TOMM22	0.834826502	6.77E-33
UCS	Cell metabolism gene	RPLP0	NME2	0.836952062	3.33E-33
UCS	Cell metabolism gene	RPLP0	GEMIN6	0.83789793	2.42E-33
UCS	Cell metabolism gene	RPLP0	PGLS	0.838849037	1.75E-33
UCS	Cell metabolism gene	RPLP0	EBP	0.839641866	1.33E-33
UCS	Cell metabolism gene	RPLP0	NME1	0.840563634	9.72E-34
UCS	Cell metabolism gene	RPLP0	SNRPE	0.841129256	7.99E-34
UCS	Cell metabolism gene	RPLP0	PFDN5	0.842370693	5.19E-34
UCS	Cell metabolism gene	RPLP0	ACOT8	0.844524951	2.43E-34
UCS	Cell metabolism gene	RPLP0	DTYMK	0.844901769	2.13E-34
UCS	Cell metabolism gene	RPLP0	TALDO1	0.84531055	1.84E-34
UCS	Cell metabolism gene	RPLP0	PSMC3	0.845897128	1.49E-34
UCS	Cell metabolism gene	RPLP0	NOP56	0.846034714	1.42E-34
UCS	Cell metabolism gene	RPLP0	POLD2	0.846515787	1.20E-34
UCS	Cell metabolism gene	RPLP0	SRM	0.846952975	1.02E-34
UCS	Cell metabolism gene	RPLP0	SSR2	0.847869126	7.33E-35
UCS	Cell metabolism gene	RPLP0	ITPA	0.848840962	5.14E-35
UCS	Cell metabolism gene	RPLP0	GEMIN7	0.851960132	1.62E-35
UCS	Cell metabolism gene	RPLP0	IMPDH2	0.852169399	1.50E-35
UCS	Cell metabolism gene	RPLP0	TIMM50	0.852986211	1.10E-35
UCS	Cell metabolism gene	RPLP0	PSMB7	0.857368949	2.06E-36
UCS	Cell metabolism gene	RPLP0	NANS	0.858331191	1.41E-36
UCS	Cell metabolism gene	RPLP0	PSMB3	0.860269896	6.57E-37
UCS	Cell metabolism gene	RPLP0	FAU	0.865797653	6.92E-38
UCS	Cell metabolism gene	RPLP0	PMPCA	0.867137863	3.95E-38
UCS	Cell metabolism gene	RPLP0	POLR2H	0.871655686	5.70E-39
UCS	Cell metabolism gene	RPLP0	SLC27A5	0.88064827	9.63E-41
UCS	Cell metabolism gene	RPLP0	TIMM8B	0.887252073	3.88E-42
UCS	Cell metabolism gene	RPLP0	HMBS	0.889139433	1.49E-42
UCS	Cell metabolism gene	RPLP0	EXOSC4	0.889177222	1.46E-42
UCS	Cell metabolism gene	RPLP0	EXOSC5	0.889206763	1.44E-42
UCS	Cell metabolism gene	RPLP0	SNRPD2	0.89098574	5.77E-43
UCS	Cell metabolism gene	RPLP0	TIMM13	0.892227237	3.01E-43
UCS	CGC	RPLP0	ASPSCR1	0.801337544	1.51E-28
UCS	CGC	RPLP0	RBM10	0.801768912	1.34E-28
UCS	CGC	RPLP0	TFPT	0.806180695	4.01E-29
UCS	CGC	RPLP0	SDHAF2	0.852110573	1.53E-35
UCS	Epifactor	RPLP0	PPM1G	0.802301136	1.16E-28
UCS	Epifactor	RPLP0	TFPT	0.806180695	4.01E-29
UCS	Epifactor	RPLP0	LAS1L	0.813492967	5.03E-30
UCS	Epifactor	RPLP0	PPP4C	0.822340015	3.61E-31
UCS	Epifactor	RPLP0	MBD3	0.822829737	3.11E-31
UCS	Epifactor	RPLP0	C17orf49	0.824436271	1.89E-31
UCS	Epifactor	RPLP0	PRPF31	0.824806054	1.69E-31
UCS	Epifactor	RPLP0	RUVBL2	0.829581254	3.74E-32
UCS	Epifactor	RPLP0	RRP8	0.839930044	1.21E-33
UCS	Epifactor	RPLP0	SIRT6	0.855541232	4.18E-36
UCS	Epifactor	RPLP0	TAF10	0.85614162	3.31E-36
UCS	Epifactor	RPLP0	PRMT1	0.865118639	9.18E-38
UCS	Epifactor	RPLP0	BRMS1	0.872796935	3.46E-39
UCS	Epifactor	RPLP0	NOC2L	0.877077382	5.06E-40
UCS	Epifactor	RPLP0	EXOSC4	0.889177222	1.46E-42
UCS	Epifactor	RPLP0	EXOSC5	0.889206763	1.44E-42
UCS	Epifactor	RPLP0	FBL	0.931660393	1.34E-54
UCS	IUPHAR	RPLP0	HMOX2	0.804790937	5.88E-29
UCS	IUPHAR	RPLP0	FKBP1A	0.811319537	9.41E-30
UCS	IUPHAR	RPLP0	PTGES2	0.81799613	1.34E-30
UCS	IUPHAR	RPLP0	ECE2	0.822705795	3.23E-31
UCS	IUPHAR	RPLP0	MFSD2B	0.850735634	2.56E-35
UCS	IUPHAR	RPLP0	IMPDH2	0.852169399	1.50E-35
UCS	IUPHAR	RPLP0	SIRT6	0.855541232	4.18E-36
UCS	IUPHAR	RPLP0	PRMT1	0.865118639	9.18E-38
UCS	IUPHAR	RPLP0	SLC27A5	0.88064827	9.63E-41
UCS	TF	RPLP0	ZBTB48	0.822388874	3.56E-31
UCS	TF	RPLP0	MBD3	0.822829737	3.11E-31
UCS	TF	RPLP0	ZNF511	0.832740399	1.35E-32
UCS	TF	RPLP0	ZNF787	0.836049236	4.50E-33
UCS	TF	RPLP0	NME2	0.836952062	3.33E-33
UCS	TF	RPLP0	REXO4	0.850075183	3.27E-35
UCS	TF	RPLP0	ZNF581	0.886984879	4.43E-42
UCS	TSG	RPLP0	NPRL2	0.801012611	1.65E-28
UCS	TSG	RPLP0	GLTSCR2	0.807326297	2.91E-29
UCS	TSG	RPLP0	PHB	0.807782007	2.56E-29
UCS	TSG	RPLP0	ZBTB48	0.822388874	3.56E-31
UCS	TSG	RPLP0	GADD45GIP1	0.834915791	6.57E-33
UCS	TSG	RPLP0	GNB2L1	0.840561031	9.73E-34
UCS	TSG	RPLP0	NME1	0.840563634	9.72E-34
UCS	TSG	RPLP0	SIRT6	0.855541232	4.18E-36
UCS	TSG	RPLP0	TSSC4	0.863567562	1.74E-37
UCS	TSG	RPLP0	BRMS1	0.872796935	3.46E-39

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPLP0	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPLP0	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPLP0	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPLP0	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPLP0	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPLP0	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPLP0	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPLP0	RPL19	1.36901182894089	0.00250792503356934
KICH	RPLP0	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPLP0	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPLP0	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPLP0	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPLP0	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPLP0	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPLP0	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPLP0	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPLP0	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPLP0	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPLP0	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPLP0	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPLP0	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPLP0	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPLP0	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPLP0	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPLP0	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPLP0	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPLP0	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPLP0	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPLP0

PAFAH1B2, RRP1B, Rrp1b, MEPCE, ESR1, UBC, CD4, HDAC5, DYRK2, STAU1, PCK1, VHL, SENP3, ARRB2, SIRT7, ERG, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, INPPL1, RPL5, RPL6, RPS6, RPS4X, RPS3, RPL21, RPL4, RPL7A, RPL7, RPL10A, RPS3A, RPSA, RPS23, RPS15A, RPS13, RPL23, RPLP1, RPS2, RPS16, RPS8, RPLP2, RPS24, RPS26, RPL18, RPL14, RPL22, RPL19, RPL23A, RPL13, RPL3, RPS11, RPL11, RPL9, RPL18A, RPL30, RPL17, RPL31, RPS14, RPS5, RPL8, RPS25, RPS10, RPS20, RPS27A, RPS21, ILF2, HNRNPU, HNRNPM, NHP2L1, DBN1, VASN, RPL10L, NDUFS8, RPLP0P6, YWHAE, PA2G4, HSP90AB1, HSP90AA1, ESR2, FN1, VCAM1, CSNK2A1, TP63, SMAD3, UBL4A, ITGA4, PAN2, CD81, IGSF8, ICAM1, NPM1, PPM1A, YWHAQ, TARDBP, PARK2, PRPF40A, GAS7, AIMP1, DARS, EEF1E1, IARS, IQGAP1, LRRFIP1, MARS, QARS, RPL24, DNAJA1, EIF2S1, FARSA, FARSB, RARS, RPL15, RPL36, RPA3, RPA2, RPA1, ZBTB1, AURKA, CEP250, HAUS2, TP53, TUBG1, HUWE1, CCNDBP1, PHF6, CUL7, OBSL1, CCDC8, TUBA8, ACOX1, WHSC1, DDX24, EEF1A1, EIF5B, EIF6, GNB2L1, GNL1, HSPA8, IDH3A, IPO8, MSH2, MTHFD1, PIK3C2A, PRPF8, RANBP2, RBBP4, RPL12, RPL13A, RPL27, RPL27A, RPL28, RPL32, RPL34, RPL35, RPL35A, RPL37A, NOC3L, PABPC1, RPL10, RPL26, RPL38, RPS17, RPN2, RPS12, RPS15, RPS18, RPS19, LOC101929876, RPS27, RPS7, RPS9, RRP7A, TDRD15, VAPA, VDAC3, NTRK1, PTEN, EWSR1, RNF2, NOP56, IBTK, Fbl, Eif3e, Srp72, Rrbp1, GAN, SKI, MCM2, CDC73, ZNF746, CNBP, RBM34, RRP8, RRS1, BHLHA15, H2AFY2, RNMTL1, ZC3HAV1, MAGEB10, NCL, EIF2AK2, INO80B, FOXA1, TRIM25, MTF1, ATXN3, CFTR, CTNNB1, LARS, PCBP1, API5, BMP4, PPIE, YAF2, YAP1, EFTUD2, AAR2, PIH1D1, CHD3, CHD4, LARP7, RIOK1, HEXIM1, PPT1, KCMF1, SNAI1, AGR2, RECQL4, REST, CDK9, RPS6KB2, NEK2, METTL14, KIAA1429, PLEKHA2, RC3H1, RC3H2, ACTC1, PHB, FAF1, KIN, NR2C2, UBQLN2, VRK1, SNRNP70, ITFG1, GSK3B, ARAF, HMGB1, ABCC6, PPP1CA, BIRC3, NFX1, WWP2, BRD7, Dnajc17, APP, ARIH2, PLEKHA4, TFCP2, FANCD2, NGB, SAMD12, ZC3H18, CDC42, NCK1, RAB5A, ANKRD55, MAU2, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, GRSF1, LRRC59, NMRAL1, NDN, BRD4, RBM45, CIC, Apc2, RBM39, FBP1, IFI16, RIN3, DNAJB7, DNAJC15, DNAJC16, DNAJC19, DNAJC1, DNAJC21, DNAJC25, DNAJC2, DRG1, DNAJC8, SETD8, OGT, DDRGK1, UFL1, TRIM37, ATG7, FZR1, WDR5, NUDCD2, NAA40, PNMAL1, ZNF397, ZNF768, BRIX1, ZBTB47, BOP1, REXO4, PATZ1, ZNF668, RPF1, MYEF2, SRPK2, SRSF6, GZF1, URB2, BUD13, CEBPZ, NEIL1, CENPL, H2AFX, HIST1H1B, EBNA1BP2, NVL, HP1BP3, TAF1C, TAF1A, TSPYL2, CENPI, AKAP17A, KIAA0020, URB1, ZC3H10, RPL26L1, GNL2, RPF2, PAK1IP1, PRKRA, MYBBP1A, ZKSCAN8, ADARB1, MPHOSPH10, DDX21, SRSF5, DDX51, NOP2, RSBN1, DDX31, DDX54, GLE1, UTP23, PPAN-P2RY11, C3orf17, ILF3, DDX27, ZNF22, PLCH1, DKC1, CENPQ, GLYR1, TAF1B, NPM3, NSA2, CCDC137, BBX, UTP3, RBM28, CDK13, LLPH, HIST1H2AG, IMP4, ZNF354A, PRDM15, PAPD5, AATF, SURF6, GTPBP4, TAF1D, SCAF1, LYAR, NOL8, NOM1, DDX56, PURG, HERC5, FXR2, KMT2A, ZNF48, KNOP1, CENPN, SRRM1, CENPV, NOP16, HIST1H1C, CCDC140, SRPK1, PRPF4B, NOC2L, FTSJ3, CDK12, NKRF, SCAF4, GLTSCR2, BMS1, TEX10, RSL1D1, ABT1, TTF1, CENPU, NIP7, CTCF, ZNF777, C1orf35, LARP1B, RPL36AL, KRI1, IMP3, C8orf33, RBM4B, PRDM10, MRPL27, DIS3L2, DDX50, LIN28A, HIST2H2AC, RRP15, PBRM1, MAGEB2, SRP68, PDCD11, ZFP62, YBX3, PURB, PURA, NSUN4, OASL, NUPL2, SF3B1, EPB41L4B, RSL24D1, FYTTD1, ZBTB41, ZNF574, RPS4Y2, STAU2, YTHDC2, RBM4, ZNF346, DDX18, NGDN, SRP14, SRSF1, ZNF770, YBX1, RBM19, ZBTB48, MAK16, HIST2H2AB, C7orf50, SPATS2L, SPTY2D1, C14orf169, CBX6, SUGP2, GTPBP10, HIST1H1E, HIST1H1A, TRIM56, LUC7L, GTF3C2, PELP1, NOL10, ZNF320, ZCCHC3, ZCCHC7, TBL2, NIFK, HIST1H2AM, ZNF317, ZNF512, SRP72, REPIN1, SDAD1, CHERP, WDR74, H2AFY, U2SURP, ZBTB11, MRPS11, NAT10, FAM111A, DICER1, MAP7D1, DHX30, GPATCH4, XRN1, RPL7L1, DHX37, LARP1, ZNF629, EPB41L5, KRR1, RSBN1L, DDX10, POP1, BTF3, FBXW7, EXOSC8, Dusp14, NLRP7, CCNF, OPTN, CALCOCO2, SIRT6, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPLP0	chr12	120636963	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPLP0	BRCA	chr12	120636935	120636935	A	G	Silent	p.L102	4
RPLP0	UCS	chr12	120637130	120637130	G	A	Silent	p.N71N	3
RPLP0	DLBC	chr12	120636498	120636498	G	A	Silent	p.S170S	3
RPLP0	UCEC	chr12	120636713	120636713	A	G	Missense_Mutation	p.F137L	3
RPLP0	UCEC	chr12	120637257	120637257	A	G	Missense_Mutation	p.I29T	3
RPLP0	HNSC	chr12	120636693	120636693	G	A	Silent	p.I143I	3
RPLP0	HNSC	chr12	120635242	120635242	G	C	Silent	p.V225V	3
RPLP0	TGCT	chr12	120637138	120637138	G	A	Silent	p.L69L	2
RPLP0	HNSC	chr12	120634606	120634606	G	A	Silent	p.D308D	2
RPLP0	LUAD	chr12	120636469	120636469	A	C	Missense_Mutation	p.I180S	2
RPLP0	STAD	chr12	120637168	120637168	T	C	Missense_Mutation	p.T59A	2
RPLP0	HNSC	chr12	120636708	120636708	G	C	Missense_Mutation	p.F138L	2
RPLP0	STAD	chr12	120635143	120635143	G	C	Silent	p.T258T	2
RPLP0	BLCA	chr12	120635157	120635157	C	G	Missense_Mutation	p.E254Q	2
RPLP0	KIRC	chr12	120636946	120636946	A	C	Missense_Mutation	p.I98S	2
RPLP0	STAD	chr12	120635184	120635184	A	G	Missense_Mutation	p.Y245H	2
RPLP0	KIRC	chr12	120635210	120635210	G	-	Frame_Shift_Del	p.S236fs	2
RPLP0	STAD	chr12	120636777	120636777	G	T	Silent	p.A115A	2
RPLP0	BRCA	chr12	120634624	120634624	T	C	Silent	p.E302	2
RPLP0	PRAD	chr12	120635152	120635152	C	T	Silent	p.T255T	2
RPLP0	STAD	chr12	120636391	120636391	A	G	Missense_Mutation	p.I206T	2
RPLP0	BRCA	chr12	120635133	120635133	C	T	Missense_Mutation	p.A262T	2
RPLP0	UCEC	chr12	120635168	120635168	G	A	Missense_Mutation	p.A250V	2
RPLP0	ESCA	chr12	120636490	120636490	G	T	Missense_Mutation		2
RPLP0	TGCT	chr12	120637138	120637138	G	A	Silent		2
RPLP0	UCEC	chr12	120637264	120637264	A	G	Missense_Mutation	p.C27R	2
RPLP0	TGCT	chr12	120637146	120637146	C	G	Missense_Mutation		2
RPLP0	UCEC	chr12	120638562	120638562	A	G	Missense_Mutation	p.W9R	2
RPLP0	TGCT	chr12	120637146	120637146	C	G	Missense_Mutation	p.R66P	2
RPLP0	CESC	chr12	120639021	120639021	G	C	Missense_Mutation		1
RPLP0	LUAD	chr12	120636414	120636414	G	C	Missense_Mutation	p.I198M	1
RPLP0	HNSC	chr12	120636708	120636708	G	C	Missense_Mutation		1
RPLP0	SKCM	chr12	120634627	120634627	C	T	Silent	p.K301K	1
RPLP0	BLCA	chr12	120636368	120636368	G	A	Missense_Mutation		1
RPLP0	TGCT	chr12	120634676	120634690	GTGGCAGCAGCCACA	-	In_Frame_Del	p.281_285del	1
RPLP0	CESC	chr12	120634585	120634585	G	C	Silent		1
RPLP0	HNSC	chr12	120636945	120636945	G	A	Silent		1
RPLP0	BLCA	chr12	120636693	120636693	G	A	Silent		1
RPLP0	THCA	chr12	120637198	120637198	C	A	Missense_Mutation		1
RPLP0	CESC	chr12	120638791	120638791	G	A	RNA	NULL	1
RPLP0	LUSC	chr12	120637225	120637225	T	A	Missense_Mutation	p.M40L	1
RPLP0	HNSC	chr12	120636428	120636428	C	T	Missense_Mutation		1
RPLP0	THYM	chr12	120637220	120637220	C	A	Missense_Mutation		1
RPLP0	CESC	chr12	120634585	120634585	G	C	Silent	p.L315	1
RPLP0	LUSC	chr12	120637226	120637226	C	A	Missense_Mutation	p.Q39H	1
RPLP0	HNSC	chr12	120636928	120636928	G	A	Missense_Mutation		1
RPLP0	STAD	chr12	120635190	120635190	T	C	Missense_Mutation	p.N243D	1
RPLP0	BLCA	chr12	120637269	120637269	G	A	Missense_Mutation	p.P25L	1
RPLP0	KIRC	chr12	120637144	120637144	C	T	Missense_Mutation	p.G67R	1
RPLP0	THYM	chr12	120637220	120637220	C	A	Missense_Mutation	p.Q41H	1
RPLP0	LUSC	chr12	120637201	120637201	G	A	Missense_Mutation	p.R48C	1
RPLP0	HNSC	chr12	120636522	120636522	C	G	Missense_Mutation		1
RPLP0	BLCA	chr12	120636368	120636368	G	A	Missense_Mutation	p.R214C	1
RPLP0	ESCA	chr12	120636490	120636490	G	T	Missense_Mutation	p.T173K	1
RPLP0	OV	chr12	120635197	120635197	A	G	Silent	p.S240S	1
RPLP0	HNSC	chr12	120636945	120636945	G	A	Silent	p.I98I	1
RPLP0	LIHC	chr12	120636498	120636498	G	A	Silent		1
RPLP0	ESCA	chr12	120638796	120638796	G	A	RNA	NULL	1
RPLP0	LIHC	chr12	120634712	120634715	GATG	-	Frame_Shift_Del	p.272_273del	1
RPLP0	TGCT	chr12	120634676	120634690	GTGGCAGCAGCCACA	-	In_Frame_Del		1
RPLP0	PRAD	chr12	120637005	120637005	C	T	Silent	p.L78L	1
RPLP0	HNSC	chr12	120636928	120636928	G	A	Missense_Mutation	p.A104V	1
RPLP0	LIHC	chr12	120634591	120634591	A	-	Frame_Shift_Del	p.F313fs	1
RPLP0	ESCA	chr12	120638796	120638796	G	A	Missense_Mutation		1
RPLP0	SARC	chr12	120634643	120634643	G	T	Missense_Mutation	p.A296D	1
RPLP0	CESC	chr12	120636468	120636468	G	T	Silent		1
RPLP0	LIHC	chr12	120636987	120636987	C	-	Frame_Shift_Del	p.G84fs	1
RPLP0	GBM	chr12	120636422	120636422	C	T	Missense_Mutation	p.G196S	1
RPLP0	SKCM	chr12	120636466	120636466	G	A	Missense_Mutation	p.S181F	1
RPLP0	BLCA	chr12	120635157	120635157	C	G	Missense_Mutation		1
RPLP0	HNSC	chr12	120636428	120636428	C	T	Missense_Mutation	p.D194N	1
RPLP0	CESC	chr12	120635255	120635255	T	C	Missense_Mutation		1
RPLP0	LIHC	chr12	120634595	120634595	C	-	Frame_Shift_Del	p.G312fs	1
RPLP0	UCS	chr12	120637130	120637130	G	A	Silent		1
RPLP0	HNSC	chr12	120635242	120635242	G	C	Silent		1
RPLP0	SKCM	chr12	120636761	120636761	C	A	Missense_Mutation	p.V121F	1
RPLP0	BLCA	chr12	120637269	120637269	G	A	Missense_Mutation		1
RPLP0	HNSC	chr12	120636522	120636522	C	G	Missense_Mutation	p.K162N	1

Copy number variation (CNV) of RPLP0
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Fusion gene breakpoints (product of the structural variants (SVs)) across RPLP0
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
103283	BLCA	TCGA-DK-A3IU	ADRBK1	chr11	67051844	+	RPLP0	chr12	120635265	-
103283	STAD	TCGA-CD-5799	ANKRD54	chr22	38236193	-	RPLP0	chr12	120635265	-
103283	STAD	TCGA-CD-5799-01A	ANKRD54	chr22	38236194	-	RPLP0	chr12	120635265	-
103283	N/A	BP431211	ATIC	chr2	216198109	+	RPLP0	chr12	120636706	-
103283	STAD	TCGA-D7-8570-01A	C16orf87	chr16	46864996	-	RPLP0	chr12	120635265	-
103283	N/A	AX381627	C9orf92	chr9	16333192	-	RPLP0	chr12	120634505	+
103283	UCEC	TCGA-EO-A3AV	CNPY2	chr12	56708634	-	RPLP0	chr12	120635265	-
103283	HNSC	TCGA-CR-5243-01A	COPS7A	chr12	6833984	+	RPLP0	chr12	120635265	-
103283	UCEC	TCGA-EO-A3AY	EIF4B	chr12	53431406	+	RPLP0	chr12	120635265	-
103283	LUSC	TCGA-21-5782	GCN1L1	chr12	120568449	-	RPLP0	chr12	120635265	-
103283	LUSC	TCGA-21-5782	GCN1L1	chr12	120568450	-	RPLP0	chr12	120635265	-
103283	LUSC	TCGA-63-A5MP	GCN1L1	chr12	120628100	-	RPLP0	chr12	120635265	-
103283	LUSC	TCGA-63-A5MP	GCN1L1	chr12	120628101	-	RPLP0	chr12	120635265	-
103283	OV	TCGA-24-1418	GCN1L1	chr12	120611456	-	RPLP0	chr12	120635265	-
103283	OV	TCGA-24-1418-01A	GCN1L1	chr12	120611457	-	RPLP0	chr12	120635265	-
103283	Non-Cancer	269N	GMNN	chr6	24780968	+	RPLP0	chr12	120635265	-
103283	PRAD	TCGA-EJ-5517	KLK3	chr19	51361547	+	RPLP0	chr12	120636676	-
103283	N/A	EC537074	MBIP	chr14	36771229	-	RPLP0	chr12	120635190	-
103283	STAD	TCGA-D7-A4Z0-01A	METAP2	chr12	95877056	+	RPLP0	chr12	120635265	-
103283	COAD	TCGA-AA-A03F-01A	PABPC1	chr8	101733796	-	RPLP0	chr12	120636800	-
103283	SKCM	TCGA-EE-A29Q-06A	PKN1	chr19	14578779	+	RPLP0	chr12	120636542	-
103283	N/A	BG180012	PPP3CB	chr10	75230844	-	RPLP0	chr12	120634606	-
103283	CESC	TCGA-EA-A50E	RASAL1	chr12	113568689	-	RPLP0	chr12	120635265	-
99621	STAD	TCGA-BR-8676-01A	RPLP0	chr12	120634522	-	ANK3	chr10	61787077	-
77108	N/A	DB294360	RPLP0	chr12	120635193	-	ASAH2B	chr10	52519001	+
77108	N/A	BE698288	RPLP0	chr12	120636993	-	CDS1	chr4	85522777	+
103262	Non-Cancer	ERR188313	RPLP0	chr12	120637247	-	EEF1A1	chr6	74228190	-
80224	N/A	AA532510	RPLP0	chr12	120634505	-	HCFC1	chrX	153214203	-
101710	N/A	AF132973	RPLP0	chr12	120635175	+	NDUFA13	chr19	19627052	+
101710	N/A	AF155662	RPLP0	chr12	120635169	+	NDUFA13	chr19	19627042	+
77221	N/A	AV695131	RPLP0	chr12	120636474	-	PYHIN1	chr1	158910478	+
103283	N/A	AA524606	RPLP0	chr12	120634627	-	RPLP0	chr12	120634720	+
77108	N/A	BG575735	RPLP0	chr12	120634502	-	RPLP0P2	chr11	61404456	+
103019	N/A	BF185929	RPLP0	chr12	120634535	-	SIPA1L3	chr19	38575289	-
103283	LUAD	TCGA-80-5608-01A	SFTPB	chr2	85889152	-	RPLP0	chr12	120636434	-
103283	OV	TCGA-04-1651	SMARCB1	chr22	24129449	+	RPLP0	chr12	120635265	-
103283	STAD	TCGA-CG-5724-01A	STIP1	chr11	63960759	+	RPLP0	chr12	120635265	-
103283	GBM	TCGA-32-2634-01A	TP53	chr17	7579312	-	RPLP0	chr12	120635265	-
103283	N/A	AX381441	TTC28	chr22	28837873	-	RPLP0	chr12	120634505	+
103285	N/A	BP429433	ZSWIM5	chr1	45661735	+	RPLP0	chr12	120634505	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPLP0	0.000831556120656951	0.023
LUAD	RPLP0	0.0195231229758836	0.53
PCPG	RPLP0	0.0221168701786344	0.58
PAAD	RPLP0	0.030390609399004	0.76
THCA	RPLP0	0.0462207210910911	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPLP0	0.0166427962937844	0.52
LGG	RPLP0	0.00792791548331948	0.25
BRCA	RPLP0	1.99963240044025e-06	6.6e-05
PAAD	RPLP0	0.030667842791955	0.89
SARC	RPLP0	0.0315501656203188	0.89
CHOL	RPLP0	0.0255086207691769	0.77

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source