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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPLP1 (NCBI Gene ID:6176)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPLP1
	Gene ID: 6176
	Gene Symbol	RPLP1
	Gene ID	6176
	Gene Name	ribosomal protein lateral stalk subunit P1
	Synonyms	LP1\|P1\|RPP1
	Cytomap	15q23
	Type of Gene	protein-coding
	Description	60S acidic ribosomal protein P1acidic ribosomal phosphoprotein P1large ribosomal subunit protein P1ribosomal protein, large, P1
	Modification date	20200313
	UniProtAcc	P05386

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0005840	Ribosome
GO:0006414	Translational elongation
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPLP1	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPLP1[title] AND translation [title] AND human.'

Gene	Title	PMID
RPLP1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000260379	69747508	69747626	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
THCA	RPLP1	-1.55724010733009	0.00553919070100212

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
BRCA	RPLP1	1	2	0.0392383490171147	0.17147149600581	0.240624286919069	-0.270070066109066	-0.178717372247846
KIRP	RPLP1	1	2	0.0367114655278887	0.174311622807018	0.225362697368421	1.75561544163894	2.06221482760363

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
READ	RPLP1	0.053366593	0.019405504
GBM	RPLP1	0.151196992	0.036971798

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPLP1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	RPLP1	SNRPD2	0.800732847	4.02E-11
CHOL	Cell metabolism gene	RPLP1	TOMM7	0.81585511	8.66E-12
DLBC	Cell metabolism gene	RPLP1	SNRPD2	0.813131742	2.20E-12
DLBC	Cell metabolism gene	RPLP1	GEMIN7	0.813604364	2.09E-12
DLBC	Cell metabolism gene	RPLP1	NME2	0.82390204	6.36E-13
DLBC	TF	RPLP1	NME2	0.82390204	6.36E-13
DLBC	TSG	RPLP1	GNB2L1	0.816596445	1.49E-12
GBM	Cell metabolism gene	RPLP1	FAU	0.825181426	5.00E-44
GBM	Cell metabolism gene	RPLP1	SSR4	0.826812723	2.43E-44
KICH	Cell metabolism gene	RPLP1	SNRPD2	0.81555784	7.39E-23
KIRP	Cell metabolism gene	RPLP1	SNRPD2	0.840657194	1.68E-87
KIRP	Cell metabolism gene	RPLP1	FAU	0.873124719	3.51E-102
KIRP	Epifactor	RPLP1	FBL	0.807303376	1.65E-75
LGG	Cell metabolism gene	RPLP1	FAU	0.812979695	4.21E-126
PCPG	Cell metabolism gene	RPLP1	PGLS	0.804751598	9.10E-44
PCPG	Cell metabolism gene	RPLP1	PFDN5	0.851931786	7.24E-54
PRAD	Cell metabolism gene	RPLP1	TOMM7	0.802199557	7.65E-125
PRAD	Cell metabolism gene	RPLP1	PFDN5	0.820896663	1.93E-135
PRAD	Cell metabolism gene	RPLP1	POLR2F	0.832056377	2.25E-142
PRAD	Cell metabolism gene	RPLP1	POLR2I	0.84236377	3.00E-149
PRAD	Cell metabolism gene	RPLP1	SNRPD2	0.866602661	1.42E-167
PRAD	Cell metabolism gene	RPLP1	FAU	0.895886422	3.14E-195
PRAD	Epifactor	RPLP1	FBL	0.848033454	3.03E-153
PRAD	TF	RPLP1	ZNF524	0.81195036	3.20E-130
PRAD	TSG	RPLP1	GADD45GIP1	0.800386697	7.09E-124
PRAD	TSG	RPLP1	GNB2L1	0.803093502	2.53E-125
THCA	Cell metabolism gene	RPLP1	SNRPD2	0.832837235	1.54E-148
THCA	Cell metabolism gene	RPLP1	FAU	0.838215071	3.17E-152
THCA	Epifactor	RPLP1	FBL	0.805805645	8.24E-132
THCA	TSG	RPLP1	GNB2L1	0.832985549	1.22E-148
THYM	Cell metabolism gene	RPLP1	PSMC1	0.800437689	1.92E-28
THYM	Cell metabolism gene	RPLP1	NANS	0.802280199	1.17E-28
THYM	Cell metabolism gene	RPLP1	SRM	0.805004939	5.54E-29
THYM	Cell metabolism gene	RPLP1	HMOX2	0.807055871	3.14E-29
THYM	Cell metabolism gene	RPLP1	HSD17B10	0.807123064	3.08E-29
THYM	Cell metabolism gene	RPLP1	TOMM7	0.807469304	2.80E-29
THYM	Cell metabolism gene	RPLP1	GEMIN7	0.807758451	2.58E-29
THYM	Cell metabolism gene	RPLP1	PMPCA	0.810023932	1.36E-29
THYM	Cell metabolism gene	RPLP1	EBP	0.810485746	1.19E-29
THYM	Cell metabolism gene	RPLP1	UROD	0.810663448	1.14E-29
THYM	Cell metabolism gene	RPLP1	PSMD4	0.81188115	8.01E-30
THYM	Cell metabolism gene	RPLP1	SNRPD3	0.817965158	1.35E-30
THYM	Cell metabolism gene	RPLP1	TIMM10	0.82272068	3.22E-31
THYM	Cell metabolism gene	RPLP1	PTGES2	0.823685556	2.39E-31
THYM	Cell metabolism gene	RPLP1	PHKG2	0.824640125	1.78E-31
THYM	Cell metabolism gene	RPLP1	SSR2	0.826625138	9.56E-32
THYM	Cell metabolism gene	RPLP1	TOMM40	0.828303021	5.63E-32
THYM	Cell metabolism gene	RPLP1	MVD	0.829977311	3.30E-32
THYM	Cell metabolism gene	RPLP1	HMBS	0.830194687	3.07E-32
THYM	Cell metabolism gene	RPLP1	PSMC3	0.830641172	2.66E-32
THYM	Cell metabolism gene	RPLP1	MIF	0.831423546	2.07E-32
THYM	Cell metabolism gene	RPLP1	POLR2H	0.833462219	1.06E-32
THYM	Cell metabolism gene	RPLP1	POLR2F	0.834530627	7.46E-33
THYM	Cell metabolism gene	RPLP1	LCMT1	0.834551229	7.41E-33
THYM	Cell metabolism gene	RPLP1	PHPT1	0.835360259	5.67E-33
THYM	Cell metabolism gene	RPLP1	EXOSC5	0.83550112	5.41E-33
THYM	Cell metabolism gene	RPLP1	GMPPA	0.835550856	5.32E-33
THYM	Cell metabolism gene	RPLP1	WBSCR22	0.83560325	5.23E-33
THYM	Cell metabolism gene	RPLP1	GUK1	0.837181022	3.08E-33
THYM	Cell metabolism gene	RPLP1	GFER	0.840287876	1.07E-33
THYM	Cell metabolism gene	RPLP1	ITPA	0.840772555	9.04E-34
THYM	Cell metabolism gene	RPLP1	SLC27A5	0.844610439	2.36E-34
THYM	Cell metabolism gene	RPLP1	PSMC5	0.845281069	1.86E-34
THYM	Cell metabolism gene	RPLP1	IDH3G	0.846651365	1.14E-34
THYM	Cell metabolism gene	RPLP1	ACOT8	0.850519298	2.77E-35
THYM	Cell metabolism gene	RPLP1	MTX1	0.852085559	1.55E-35
THYM	Cell metabolism gene	RPLP1	PSMB7	0.856431144	2.96E-36
THYM	Cell metabolism gene	RPLP1	EXOSC4	0.862652312	2.52E-37
THYM	Cell metabolism gene	RPLP1	PSMB3	0.864455494	1.21E-37
THYM	Cell metabolism gene	RPLP1	PPCDC	0.866348471	5.50E-38
THYM	Cell metabolism gene	RPLP1	DPM3	0.872303017	4.30E-39
THYM	Cell metabolism gene	RPLP1	POLR2J	0.874338189	1.74E-39
THYM	Cell metabolism gene	RPLP1	TIMM13	0.880961711	8.31E-41
THYM	Cell metabolism gene	RPLP1	TIMM8B	0.882714076	3.60E-41
THYM	Cell metabolism gene	RPLP1	SNRPD2	0.88714459	4.09E-42
THYM	Cell metabolism gene	RPLP1	TIMM50	0.895489661	5.26E-44
THYM	Cell metabolism gene	RPLP1	APRT	0.897572599	1.68E-44
THYM	Cell metabolism gene	RPLP1	PFDN5	0.902339133	1.11E-45
THYM	Cell metabolism gene	RPLP1	PGLS	0.909799023	1.18E-47
THYM	Cell metabolism gene	RPLP1	DPM2	0.918978714	2.50E-50
THYM	Cell metabolism gene	RPLP1	POLR2I	0.922613702	1.77E-51
THYM	Cell metabolism gene	RPLP1	FAU	0.926934736	6.43E-53
THYM	CGC	RPLP1	MAP2K2	0.814046901	4.29E-30
THYM	CGC	RPLP1	ASPSCR1	0.822426764	3.52E-31
THYM	CGC	RPLP1	SDHAF2	0.824744872	1.72E-31
THYM	CGC	RPLP1	TFPT	0.826635305	9.53E-32
THYM	CGC	RPLP1	RBM10	0.847424117	8.61E-35
THYM	CGC	RPLP1	MGMT	0.854270826	6.79E-36
THYM	Epifactor	RPLP1	LAS1L	0.807544278	2.74E-29
THYM	Epifactor	RPLP1	PPP4C	0.808450234	2.12E-29
THYM	Epifactor	RPLP1	PELP1	0.808652894	2.01E-29
THYM	Epifactor	RPLP1	RUVBL2	0.809187324	1.73E-29
THYM	Epifactor	RPLP1	PAF1	0.825854594	1.22E-31
THYM	Epifactor	RPLP1	TFPT	0.826635305	9.53E-32
THYM	Epifactor	RPLP1	DMAP1	0.832971157	1.25E-32
THYM	Epifactor	RPLP1	MBD3	0.835204944	5.97E-33
THYM	Epifactor	RPLP1	EXOSC5	0.83550112	5.41E-33
THYM	Epifactor	RPLP1	C17orf49	0.84067543	9.35E-34
THYM	Epifactor	RPLP1	NOC2L	0.846451055	1.22E-34
THYM	Epifactor	RPLP1	CCDC101	0.856237634	3.19E-36
THYM	Epifactor	RPLP1	EXOSC4	0.862652312	2.52E-37
THYM	Epifactor	RPLP1	INO80E	0.874072532	1.96E-39
THYM	Epifactor	RPLP1	FBL	0.883865667	2.06E-41
THYM	Epifactor	RPLP1	BRMS1	0.888488868	2.08E-42
THYM	Epifactor	RPLP1	SIRT6	0.888659894	1.91E-42
THYM	Epifactor	RPLP1	TAF10	0.896175935	3.62E-44
THYM	Epifactor	RPLP1	ZNHIT1	0.899888954	4.56E-45
THYM	Epifactor	RPLP1	PRPF31	0.904929268	2.40E-46
THYM	IUPHAR	RPLP1	ATP6V0B	0.803855809	7.60E-29
THYM	IUPHAR	RPLP1	HMOX2	0.807055871	3.14E-29
THYM	IUPHAR	RPLP1	MMP24	0.813423977	5.14E-30
THYM	IUPHAR	RPLP1	MAP2K2	0.814046901	4.29E-30
THYM	IUPHAR	RPLP1	PTGES2	0.823685556	2.39E-31
THYM	IUPHAR	RPLP1	PHKG2	0.824640125	1.78E-31
THYM	IUPHAR	RPLP1	MVD	0.829977311	3.30E-32
THYM	IUPHAR	RPLP1	SLC27A5	0.844610439	2.36E-34
THYM	IUPHAR	RPLP1	SIRT3	0.85217635	1.50E-35
THYM	IUPHAR	RPLP1	SIRT6	0.888659894	1.91E-42
THYM	Kinase	RPLP1	MAP2K2	0.814046901	4.29E-30
THYM	Kinase	RPLP1	PHKG2	0.824640125	1.78E-31
THYM	TF	RPLP1	DRAP1	0.812310804	7.08E-30
THYM	TF	RPLP1	REXO4	0.815611109	2.71E-30
THYM	TF	RPLP1	CENPB	0.817521437	1.54E-30
THYM	TF	RPLP1	ZNF511	0.820076423	7.19E-31
THYM	TF	RPLP1	GLI4	0.82464595	1.77E-31
THYM	TF	RPLP1	ZNF428	0.830767029	2.56E-32
THYM	TF	RPLP1	MBD3	0.835204944	5.97E-33
THYM	TF	RPLP1	ZNF32	0.837544833	2.72E-33
THYM	TF	RPLP1	ZNF580	0.839146465	1.58E-33
THYM	TF	RPLP1	ZNF688	0.83962372	1.34E-33
THYM	TF	RPLP1	THAP3	0.849255279	4.42E-35
THYM	TF	RPLP1	ZNF524	0.86330669	1.93E-37
THYM	TF	RPLP1	ZNF581	0.865563145	7.63E-38
THYM	TF	RPLP1	ZNF787	0.885413129	9.68E-42
THYM	TF	RPLP1	THAP7	0.906048407	1.22E-46
THYM	TSG	RPLP1	ST20	0.801887752	1.30E-28
THYM	TSG	RPLP1	STUB1	0.810381018	1.23E-29
THYM	TSG	RPLP1	GABARAP	0.839919252	1.21E-33
THYM	TSG	RPLP1	PARK7	0.849770112	3.66E-35
THYM	TSG	RPLP1	NPRL2	0.851570665	1.88E-35
THYM	TSG	RPLP1	SIRT3	0.85217635	1.50E-35
THYM	TSG	RPLP1	GNB2L1	0.852414787	1.37E-35
THYM	TSG	RPLP1	GLTSCR2	0.858336587	1.41E-36
THYM	TSG	RPLP1	TSSC4	0.884442254	1.56E-41
THYM	TSG	RPLP1	BRMS1	0.888488868	2.08E-42
THYM	TSG	RPLP1	SIRT6	0.888659894	1.91E-42
THYM	TSG	RPLP1	GADD45GIP1	0.912149292	2.61E-48
UCEC	Cell metabolism gene	RPLP1	PFDN5	0.808114666	1.26E-47
UCS	Cell metabolism gene	RPLP1	PSMC1	0.800437689	1.92E-28
UCS	Cell metabolism gene	RPLP1	NANS	0.802280199	1.17E-28
UCS	Cell metabolism gene	RPLP1	SRM	0.805004939	5.54E-29
UCS	Cell metabolism gene	RPLP1	HMOX2	0.807055871	3.14E-29
UCS	Cell metabolism gene	RPLP1	HSD17B10	0.807123064	3.08E-29
UCS	Cell metabolism gene	RPLP1	TOMM7	0.807469304	2.80E-29
UCS	Cell metabolism gene	RPLP1	GEMIN7	0.807758451	2.58E-29
UCS	Cell metabolism gene	RPLP1	PMPCA	0.810023932	1.36E-29
UCS	Cell metabolism gene	RPLP1	EBP	0.810485746	1.19E-29
UCS	Cell metabolism gene	RPLP1	UROD	0.810663448	1.14E-29
UCS	Cell metabolism gene	RPLP1	PSMD4	0.81188115	8.01E-30
UCS	Cell metabolism gene	RPLP1	SNRPD3	0.817965158	1.35E-30
UCS	Cell metabolism gene	RPLP1	TIMM10	0.82272068	3.22E-31
UCS	Cell metabolism gene	RPLP1	PTGES2	0.823685556	2.39E-31
UCS	Cell metabolism gene	RPLP1	PHKG2	0.824640125	1.78E-31
UCS	Cell metabolism gene	RPLP1	SSR2	0.826625138	9.56E-32
UCS	Cell metabolism gene	RPLP1	TOMM40	0.828303021	5.63E-32
UCS	Cell metabolism gene	RPLP1	MVD	0.829977311	3.30E-32
UCS	Cell metabolism gene	RPLP1	HMBS	0.830194687	3.07E-32
UCS	Cell metabolism gene	RPLP1	PSMC3	0.830641172	2.66E-32
UCS	Cell metabolism gene	RPLP1	MIF	0.831423546	2.07E-32
UCS	Cell metabolism gene	RPLP1	POLR2H	0.833462219	1.06E-32
UCS	Cell metabolism gene	RPLP1	POLR2F	0.834530627	7.46E-33
UCS	Cell metabolism gene	RPLP1	LCMT1	0.834551229	7.41E-33
UCS	Cell metabolism gene	RPLP1	PHPT1	0.835360259	5.67E-33
UCS	Cell metabolism gene	RPLP1	EXOSC5	0.83550112	5.41E-33
UCS	Cell metabolism gene	RPLP1	GMPPA	0.835550856	5.32E-33
UCS	Cell metabolism gene	RPLP1	WBSCR22	0.83560325	5.23E-33
UCS	Cell metabolism gene	RPLP1	GUK1	0.837181022	3.08E-33
UCS	Cell metabolism gene	RPLP1	GFER	0.840287876	1.07E-33
UCS	Cell metabolism gene	RPLP1	ITPA	0.840772555	9.04E-34
UCS	Cell metabolism gene	RPLP1	SLC27A5	0.844610439	2.36E-34
UCS	Cell metabolism gene	RPLP1	PSMC5	0.845281069	1.86E-34
UCS	Cell metabolism gene	RPLP1	IDH3G	0.846651365	1.14E-34
UCS	Cell metabolism gene	RPLP1	ACOT8	0.850519298	2.77E-35
UCS	Cell metabolism gene	RPLP1	MTX1	0.852085559	1.55E-35
UCS	Cell metabolism gene	RPLP1	PSMB7	0.856431144	2.96E-36
UCS	Cell metabolism gene	RPLP1	EXOSC4	0.862652312	2.52E-37
UCS	Cell metabolism gene	RPLP1	PSMB3	0.864455494	1.21E-37
UCS	Cell metabolism gene	RPLP1	PPCDC	0.866348471	5.50E-38
UCS	Cell metabolism gene	RPLP1	DPM3	0.872303017	4.30E-39
UCS	Cell metabolism gene	RPLP1	POLR2J	0.874338189	1.74E-39
UCS	Cell metabolism gene	RPLP1	TIMM13	0.880961711	8.31E-41
UCS	Cell metabolism gene	RPLP1	TIMM8B	0.882714076	3.60E-41
UCS	Cell metabolism gene	RPLP1	SNRPD2	0.88714459	4.09E-42
UCS	Cell metabolism gene	RPLP1	TIMM50	0.895489661	5.26E-44
UCS	Cell metabolism gene	RPLP1	APRT	0.897572599	1.68E-44
UCS	Cell metabolism gene	RPLP1	PFDN5	0.902339133	1.11E-45
UCS	Cell metabolism gene	RPLP1	PGLS	0.909799023	1.18E-47
UCS	Cell metabolism gene	RPLP1	DPM2	0.918978714	2.50E-50
UCS	Cell metabolism gene	RPLP1	POLR2I	0.922613702	1.77E-51
UCS	Cell metabolism gene	RPLP1	FAU	0.926934736	6.43E-53
UCS	CGC	RPLP1	MAP2K2	0.814046901	4.29E-30
UCS	CGC	RPLP1	ASPSCR1	0.822426764	3.52E-31
UCS	CGC	RPLP1	SDHAF2	0.824744872	1.72E-31
UCS	CGC	RPLP1	TFPT	0.826635305	9.53E-32
UCS	CGC	RPLP1	RBM10	0.847424117	8.61E-35
UCS	CGC	RPLP1	MGMT	0.854270826	6.79E-36
UCS	Epifactor	RPLP1	LAS1L	0.807544278	2.74E-29
UCS	Epifactor	RPLP1	PPP4C	0.808450234	2.12E-29
UCS	Epifactor	RPLP1	PELP1	0.808652894	2.01E-29
UCS	Epifactor	RPLP1	RUVBL2	0.809187324	1.73E-29
UCS	Epifactor	RPLP1	PAF1	0.825854594	1.22E-31
UCS	Epifactor	RPLP1	TFPT	0.826635305	9.53E-32
UCS	Epifactor	RPLP1	DMAP1	0.832971157	1.25E-32
UCS	Epifactor	RPLP1	MBD3	0.835204944	5.97E-33
UCS	Epifactor	RPLP1	EXOSC5	0.83550112	5.41E-33
UCS	Epifactor	RPLP1	C17orf49	0.84067543	9.35E-34
UCS	Epifactor	RPLP1	NOC2L	0.846451055	1.22E-34
UCS	Epifactor	RPLP1	CCDC101	0.856237634	3.19E-36
UCS	Epifactor	RPLP1	EXOSC4	0.862652312	2.52E-37
UCS	Epifactor	RPLP1	INO80E	0.874072532	1.96E-39
UCS	Epifactor	RPLP1	FBL	0.883865667	2.06E-41
UCS	Epifactor	RPLP1	BRMS1	0.888488868	2.08E-42
UCS	Epifactor	RPLP1	SIRT6	0.888659894	1.91E-42
UCS	Epifactor	RPLP1	TAF10	0.896175935	3.62E-44
UCS	Epifactor	RPLP1	ZNHIT1	0.899888954	4.56E-45
UCS	Epifactor	RPLP1	PRPF31	0.904929268	2.40E-46
UCS	IUPHAR	RPLP1	ATP6V0B	0.803855809	7.60E-29
UCS	IUPHAR	RPLP1	HMOX2	0.807055871	3.14E-29
UCS	IUPHAR	RPLP1	MMP24	0.813423977	5.14E-30
UCS	IUPHAR	RPLP1	MAP2K2	0.814046901	4.29E-30
UCS	IUPHAR	RPLP1	PTGES2	0.823685556	2.39E-31
UCS	IUPHAR	RPLP1	PHKG2	0.824640125	1.78E-31
UCS	IUPHAR	RPLP1	MVD	0.829977311	3.30E-32
UCS	IUPHAR	RPLP1	SLC27A5	0.844610439	2.36E-34
UCS	IUPHAR	RPLP1	SIRT3	0.85217635	1.50E-35
UCS	IUPHAR	RPLP1	SIRT6	0.888659894	1.91E-42
UCS	Kinase	RPLP1	MAP2K2	0.814046901	4.29E-30
UCS	Kinase	RPLP1	PHKG2	0.824640125	1.78E-31
UCS	TF	RPLP1	DRAP1	0.812310804	7.08E-30
UCS	TF	RPLP1	REXO4	0.815611109	2.71E-30
UCS	TF	RPLP1	CENPB	0.817521437	1.54E-30
UCS	TF	RPLP1	ZNF511	0.820076423	7.19E-31
UCS	TF	RPLP1	GLI4	0.82464595	1.77E-31
UCS	TF	RPLP1	ZNF428	0.830767029	2.56E-32
UCS	TF	RPLP1	MBD3	0.835204944	5.97E-33
UCS	TF	RPLP1	ZNF32	0.837544833	2.72E-33
UCS	TF	RPLP1	ZNF580	0.839146465	1.58E-33
UCS	TF	RPLP1	ZNF688	0.83962372	1.34E-33
UCS	TF	RPLP1	THAP3	0.849255279	4.42E-35
UCS	TF	RPLP1	ZNF524	0.86330669	1.93E-37
UCS	TF	RPLP1	ZNF581	0.865563145	7.63E-38
UCS	TF	RPLP1	ZNF787	0.885413129	9.68E-42
UCS	TF	RPLP1	THAP7	0.906048407	1.22E-46
UCS	TSG	RPLP1	ST20	0.801887752	1.30E-28
UCS	TSG	RPLP1	STUB1	0.810381018	1.23E-29
UCS	TSG	RPLP1	GABARAP	0.839919252	1.21E-33
UCS	TSG	RPLP1	PARK7	0.849770112	3.66E-35
UCS	TSG	RPLP1	NPRL2	0.851570665	1.88E-35
UCS	TSG	RPLP1	SIRT3	0.85217635	1.50E-35
UCS	TSG	RPLP1	GNB2L1	0.852414787	1.37E-35
UCS	TSG	RPLP1	GLTSCR2	0.858336587	1.41E-36
UCS	TSG	RPLP1	TSSC4	0.884442254	1.56E-41
UCS	TSG	RPLP1	BRMS1	0.888488868	2.08E-42
UCS	TSG	RPLP1	SIRT6	0.888659894	1.91E-42
UCS	TSG	RPLP1	GADD45GIP1	0.912149292	2.61E-48
UVM	Cell metabolism gene	RPLP1	MPST	0.800502798	5.08E-19
UVM	Cell metabolism gene	RPLP1	FAU	0.841200311	1.58E-22
UVM	Epifactor	RPLP1	FBL	0.897626865	1.77E-29
UVM	IUPHAR	RPLP1	MPST	0.800502798	5.08E-19
UVM	TF	RPLP1	REXO4	0.818138614	1.97E-20
UVM	TSG	RPLP1	GNB2L1	0.84796183	3.32E-23
UVM	TSG	RPLP1	GLTSCR2	0.865042085	4.47E-25

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPLP1	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPLP1	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPLP1	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPLP1	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPLP1	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPLP1	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPLP1	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPLP1	RPL19	1.36901182894089	0.00250792503356934
KICH	RPLP1	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPLP1	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPLP1	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPLP1	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPLP1	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPLP1	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPLP1	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPLP1	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPLP1	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPLP1	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPLP1	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPLP1	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPLP1	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPLP1	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPLP1	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPLP1	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPLP1	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPLP1	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPLP1	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPLP1	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPLP1

RPLP2, MPC2, ANKRD13B, ATP5J2, NUDT3, PFDN1, XRCC6, NUDT21, NSF, RPA2, PTN, LRIF1, ASCC2, BRD7, EEF1A1, TUBB2A, SAT1, RPLP1, MGMT, CD4, PPP2CB, GSK3B, TPT1, CDIPT, MAP1LC3B, GEMIN7, UBE2D3, RPS6KA6, TAB1, CDK2AP2, C11orf58, ARRB2, SIRT7, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, CAND1, NEDD8, RPS15, RPS16, RPS13, RPL4, RPS15A, RPS2, RPSA, RPS7, RPS4X, RPS11, RPS6, RPS8, RPLP0, RPS5, RPS3A, RPS26, RPS23, RPL11, RPS3, RPS17, RPL23, RPS24, RPS19, RPL6, RPS10, RPL12, RPS25, RPL7A, RPS21, RPS27A, EIF3A, HNRNPU, TMEM165, RPLP0P6, IGBP1, HSPA5, FUS, MRPS35, CSNK2A1, IFIT1, IFIT2, UBL4A, NPM1, ADRB2, CLIC1, RCHY1, RPL19, FARSB, RNF2, BMI1, ABL1, RPL10A, RPL14, RPL18, RPL27A, RPL29, RPL30, RPL37A, RPL10, RPL13, RPL15, RPL18A, RPL21, RPL23A, RPL24, RPL27, RPL28, RPL3, RPL31, RPL34, RPL36, RPL38, RPL5, RPL7, RPL9, RPS20, RPS14, RPS18, LOC101929876, IBTK, FOXL2, RRS1, CNBP, NCL, CYLD, TRIM25, BRCA1, CFTR, ARL2, ASCC3, DCTN2, PELO, RIPK4, PRPF8, AAR2, PIH1D1, EFTUD2, TNIP2, CHD3, CHD4, LARP7, TNF, SPDL1, PRKCZ, ESR2, HEXIM1, MEPCE, SNAI1, RECQL4, REST, ZFP36L2, CDK9, KIAA1429, RC3H1, RC3H2, ATG16L1, ACTC1, PHB, RBX1, USP14, NR2C2, PPP1CC, VRK3, HIST1H4A, IRF2, MAP3K14, OAS3, RAB27A, SNRNP70, ITFG1, BIRC3, LMBR1L, WWP2, TP53, Dnajc17, APP, SUOX, ARIH2, ZC3H18, AXL, CDC42, GRB10, ORF14, NEK4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, LDLR, INS, PTP4A3, RBM45, Apc2, FBP1, RIN3, CPSF3L, KDM4D, COPRS, DDX58, PARK2, UFL1, DDRGK1, FZR1, NUDCD2, NAA40, ADARB1, SRSF6, MAGEB2, RPL13A, PRKRA, HIST1H1E, ZNF668, HIST1H1A, ZNF346, SURF6, BTF3, JMJD6, FBXW7, RB1CC1, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPLP1	ESCA	chr15	69745321	69745321	T	C	Missense_Mutation	p.S12P	3
RPLP1	BLCA	chr15	69746006	69746006	C	T	Silent	p.L31L	3
RPLP1	TGCT	chr15	69747557	69747557	G	T	Missense_Mutation	p.G66C	2
RPLP1	UCEC	chr15	69745320	69745320	C	T	Silent	p.Y11	2
RPLP1	ESCA	chr15	69745321	69745321	T	C	Missense_Mutation		2
RPLP1	LUAD	chr15	69747561	69747561	G	T	Missense_Mutation	p.G67V	2
RPLP1	BLCA	chr15	69746006	69746006	C	T	Silent		2
RPLP1	STAD	chr15	69747800	69747800	A	G	Missense_Mutation	p.E100G	2
RPLP1	TGCT	chr15	69747557	69747557	G	T	Missense_Mutation		2
RPLP1	COAD	chr15	69747836	69747836	T	-	Frame_Shift_Del	p.L87fs	1
RPLP1	LIHC	chr15	69747786	69747786	A	G	Missense_Mutation		1
RPLP1	LIHC	chr15	69745186	69745186	C	T	Missense_Mutation		1
RPLP1	OV	chr15	67534864	67534864	G	C	Missense_Mutation	p.E103D	1
RPLP1	PRAD	chr15	69747804	69747804	C	T	Missense_Mutation	p.P37L	1
RPLP1	PRAD	chr15	69747510	69747510	C	T	Splice_Site	p.A50_splice	1

Copy number variation (CNV) of RPLP1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPLP1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
98940	COAD	TCGA-A6-6648-01A	AHCY	chr20	32883201	-	RPLP1	chr15	69745986	+
98940	N/A	BG231204	CAMK1D	chr10	12791060	-	RPLP1	chr15	69747885	-
98940	N/A	AA507501	DDHD1	chr14	53528816	+	RPLP1	chr15	69747885	-
98940	DLBC	TCGA-FA-8693	DDX49	chr19	19037186	+	RPLP1	chr15	69747508	+
98940	LUSC	TCGA-85-8354-01A	DHX30	chr3	47884745	+	RPLP1	chr15	69745170	+
98940	N/A	AA535760	DUOX1	chr15	45450017	-	RPLP1	chr15	69747885	-
98940	N/A	BG152805	FOXP1	chr3	71439009	-	RPLP1	chr15	69747885	-
98940	Non-Cancer	ERR315395	HBB	chr11	5248177	-	RPLP1	chr15	69745218	+
98940	STAD	TCGA-BR-8059-01A	HYI	chr1	43918629	-	RPLP1	chr15	69745181	+
98940	N/A	AA527609	MAGI1	chr3	65780426	-	RPLP1	chr15	69748290	-
98940	Non-Cancer	TCGA-IP-7968-11A	NOP2	chr12	6676982	-	RPLP1	chr15	69747509	+
98940	N/A	EC560210	QRICH1	chr3	49124174	+	RPLP1	chr15	69745200	+
98940	N/A	AA492344	RGS7	chr1	241161840	+	RPLP1	chr15	69747885	-
77145	N/A	BP227803	RPLP1	chr15	69747624	+	ADCY4	chr14	24792222	-
86047	N/A	AV710342	RPLP1	chr15	69747885	+	ARL13B	chr3	93748204	-
94786	N/A	CX751919	RPLP1	chr15	69746060	+	ASH2L	chr8	37985814	+
77145	N/A	BP282140	RPLP1	chr15	69747810	+	CLTB	chr5	175824659	-
102173	OV	TCGA-13-1483-01A	RPLP1	chr15	69745288	+	COL1A1	chr17	48261716	-
91466	N/A	BP228221	RPLP1	chr15	69747885	+	FUT8	chr14	65882421	-
87953	N/A	EC524131	RPLP1	chr15	69747885	+	MAGI1	chr3	65780470	+
87220	N/A	CF124678	RPLP1	chr15	69747885	+	MAP7	chr6	136685538	+
98205	N/A	BF246865	RPLP1	chr15	69747791	+	PEX6	chr6	42942214	-
84282	N/A	BF217839	RPLP1	chr15	69747884	+	PHEX	chrX	22091785	-
102362	N/A	BG272988	RPLP1	chr15	69747885	+	RBFOX1	chr16	6749321	-
81684	N/A	BG031532	RPLP1	chr15	69747885	+	RCC2	chr1	17742209	+
77145	N/A	BF218424	RPLP1	chr15	69747881	+	RGN	chrX	46938839	-
94784	N/A	AA888256	RPLP1	chr15	69747885	+	RGS7	chr1	241161840	-
102141	N/A	AW023770	RPLP1	chr15	69747885	+	SACS	chr13	23983516	-
81823	N/A	BM768334	RPLP1	chr15	69747886	+	SIAH2	chr3	150459103	-
100100	N/A	AA513253	RPLP1	chr15	69747885	+	STAG2	chrX	123460108	-
87659	N/A	CD240428	RPLP1	chr15	69747615	-	STON1-GTF2A1L	chr2	48976594	+
98157	UCEC	TCGA-B5-A3FD	RPLP1	chr15	69745359	+	TJP1	chr15	30092905	-
92404	PRAD	TCGA-V1-A9O5-06A	RPLP1	chr15	69748172	-	TMEFF2	chr2	193059642	-
101989	N/A	BG577163	RPLP1	chr15	69747885	+	TPK1	chr7	144434172	+
98940	N/A	EC580353	SLC25A48	chr5	135014721	+	RPLP1	chr15	69745209	+
98940	N/A	AA533451	ST3GAL2	chr16	70465562	-	RPLP1	chr15	69747885	-
98940	N/A	AA483605	STAG2	chrX	123460108	+	RPLP1	chr15	69747885	-
98940	N/A	AA888389	STAG2	chrX	123460108	+	RPLP1	chr15	69747874	-
98940	N/A	AW051863	STAG2	chrX	123460108	+	RPLP1	chr15	69747884	-
98940	KIRC	TCGA-BP-4770-01A	THBS1	chr15	39888996	+	RPLP1	chr15	69745317	+
98940	BRCA	TCGA-LD-A66U	TNRC6B	chr22	40521866	+	RPLP1	chr15	69747508	+
98941	N/A	BI006044	WDR33	chr2	128471524	-	RPLP1	chr15	69745311	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	RPLP1	0.0189035277365141	0.53
KIRC	RPLP1	0.0347855326570698	0.94
LUSC	RPLP1	0.0371932995274861	0.97

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	RPLP1	0.0388600652651275	1
LUSC	RPLP1	0.000877976111177409	0.029
KIRC	RPLP1	0.0466862182221575	1
LGG	RPLP1	0.0335714760786064	1
BRCA	RPLP1	0.0314938428449604	1
SARC	RPLP1	0.0356986386827159	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source