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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS2 (NCBI Gene ID:6187)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS2
	Gene ID: 6187
	Gene Symbol	RPS2
	Gene ID	6187
	Gene Name	ribosomal protein S2
	Synonyms	LLREP3\|S2
	Cytomap	16p13.3
	Type of Gene	protein-coding
	Description	40S ribosomal protein S240S ribosomal protein S4OK/KNS-cl.6protein LLRep3small ribosomal subunit protein uS5
	Modification date	20200313
	UniProtAcc	P15880

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS2	GO:0051443	positive regulation of ubiquitin-protein transferase activity	18573314

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS2	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS2[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000343262	2012497	2012657	Frame-shift
ENST00000343262	2012736	2012910	In-frame
ENST00000343262	2013149	2013257	In-frame
ENST00000343262	2014276	2014366	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000343262	2012736	2012910	1002	433	606	293	125	183
ENST00000343262	2013149	2013257	1002	325	432	293	89	125
ENST00000343262	2014276	2014366	1002	235	324	293	59	89

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P15880	59	89	2	293	Chain	ID=PRO_0000131673;Note=40S ribosomal protein S2
P15880	125	183	2	293	Chain	ID=PRO_0000131673;Note=40S ribosomal protein S2
P15880	89	125	2	293	Chain	ID=PRO_0000131673;Note=40S ribosomal protein S2
P15880	125	183	102	165	Domain	Note=S5 DRBM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00268
P15880	89	125	102	165	Domain	Note=S5 DRBM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00268

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
THCA	RPS2	-2.9749691422722	1.8399565126656e-05
KIRC	RPS2	-3.31623058345719	2.17100738110179e-12
KIRP	RPS2	-2.72788021566791	5.12227416038514e-08
LUAD	RPS2	-2.88992098496468	6.51132046672323e-08
KICH	RPS2	-4.73426315307469	8.34465026855468e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
THCA	RPS2	hsa-miR-193a-5p	99	0.329406037000974	0.00317022591831573

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
SARC	RPS2	-0.235996403	0.017827745
ESCA	RPS2	-0.06593018	0.024133994

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	RPS2	SNRPD2	0.838855239	6.28E-13
CHOL	Epifactor	RPS2	FBL	0.82563377	2.97E-12
CHOL	TSG	RPS2	GNB2L1	0.830558639	1.69E-12
DLBC	Cell metabolism gene	RPS2	SNRPD2	0.820402676	9.61E-13
DLBC	Cell metabolism gene	RPS2	TOMM22	0.829681327	3.15E-13
DLBC	Cell metabolism gene	RPS2	NME2	0.830459136	2.86E-13
DLBC	CGC	RPS2	NACA	0.836987659	1.25E-13
DLBC	Epifactor	RPS2	FBL	0.807095152	4.27E-12
DLBC	TF	RPS2	NME2	0.830459136	2.86E-13
DLBC	TSG	RPS2	GAS5	0.812395857	2.39E-12
DLBC	TSG	RPS2	GNB2L1	0.886186602	5.61E-17
GBM	TSG	RPS2	GNB2L1	0.816819222	1.82E-42
KICH	Cell metabolism gene	RPS2	RNPS1	0.820255882	2.62E-23
LAML	Epifactor	RPS2	FBL	0.821183568	1.62E-43
LAML	TSG	RPS2	GLTSCR2	0.83185396	1.37E-45
LGG	Epifactor	RPS2	FBL	0.809336653	4.05E-124
LGG	TSG	RPS2	GNB2L1	0.820717538	1.84E-130
PAAD	Cell metabolism gene	RPS2	FAU	0.816387729	5.02E-45
PCPG	Cell metabolism gene	RPS2	PFDN5	0.806914251	3.62E-44
PCPG	Cell metabolism gene	RPS2	PGLS	0.809131483	1.39E-44
PCPG	TSG	RPS2	GNB2L1	0.817914381	2.75E-46
PCPG	TSG	RPS2	GLTSCR2	0.818079208	2.55E-46
PRAD	Cell metabolism gene	RPS2	TIMM9	0.803136473	2.40E-125
PRAD	Cell metabolism gene	RPS2	NME2	0.837303454	8.17E-146
PRAD	CGC	RPS2	NACA	0.872972643	5.40E-173
PRAD	Epifactor	RPS2	FBL	0.823078924	9.31E-137
PRAD	TF	RPS2	ZNF581	0.831347211	6.42E-142
PRAD	TF	RPS2	NME2	0.837303454	8.17E-146
PRAD	TSG	RPS2	GAS5	0.861048455	4.52E-163
PRAD	TSG	RPS2	GNB2L1	0.920839205	2.73E-226
THCA	TSG	RPS2	GNB2L1	0.867153369	1.06E-174
THYM	Cell metabolism gene	RPS2	DOHH	0.800019586	2.15E-28
THYM	Cell metabolism gene	RPS2	DGKZ	0.800230782	2.03E-28
THYM	Cell metabolism gene	RPS2	NME2	0.801327495	1.51E-28
THYM	Cell metabolism gene	RPS2	TIMM17B	0.801428096	1.47E-28
THYM	Cell metabolism gene	RPS2	SNRPE	0.802892407	9.89E-29
THYM	Cell metabolism gene	RPS2	TSTA3	0.803249692	8.97E-29
THYM	Cell metabolism gene	RPS2	LSM2	0.803914848	7.48E-29
THYM	Cell metabolism gene	RPS2	PTGES2	0.804618644	6.17E-29
THYM	Cell metabolism gene	RPS2	TBCB	0.806840154	3.33E-29
THYM	Cell metabolism gene	RPS2	ATP5G1	0.80725882	2.97E-29
THYM	Cell metabolism gene	RPS2	LSM4	0.808206202	2.28E-29
THYM	Cell metabolism gene	RPS2	ALG3	0.808818477	1.92E-29
THYM	Cell metabolism gene	RPS2	MPST	0.811072634	1.01E-29
THYM	Cell metabolism gene	RPS2	PSMD13	0.811239076	9.63E-30
THYM	Cell metabolism gene	RPS2	NME1	0.811768616	8.28E-30
THYM	Cell metabolism gene	RPS2	LCMT1	0.812408231	6.89E-30
THYM	Cell metabolism gene	RPS2	EXOSC1	0.812642429	6.44E-30
THYM	Cell metabolism gene	RPS2	PSMC5	0.816545344	2.06E-30
THYM	Cell metabolism gene	RPS2	GUK1	0.816631224	2.01E-30
THYM	Cell metabolism gene	RPS2	PSME2	0.817641045	1.49E-30
THYM	Cell metabolism gene	RPS2	SNRPD3	0.818825375	1.05E-30
THYM	Cell metabolism gene	RPS2	DGUOK	0.819647352	8.18E-31
THYM	Cell metabolism gene	RPS2	IMPDH2	0.825317735	1.44E-31
THYM	Cell metabolism gene	RPS2	MIF	0.825621597	1.31E-31
THYM	Cell metabolism gene	RPS2	GMPPA	0.825884872	1.21E-31
THYM	Cell metabolism gene	RPS2	WBSCR22	0.828864934	4.71E-32
THYM	Cell metabolism gene	RPS2	DPM3	0.829264399	4.14E-32
THYM	Cell metabolism gene	RPS2	PHKG2	0.830976464	2.39E-32
THYM	Cell metabolism gene	RPS2	TIMM10	0.831417087	2.07E-32
THYM	Cell metabolism gene	RPS2	POLR2J	0.831447126	2.05E-32
THYM	Cell metabolism gene	RPS2	PSMD4	0.832534911	1.44E-32
THYM	Cell metabolism gene	RPS2	PMPCA	0.835558205	5.31E-33
THYM	Cell metabolism gene	RPS2	NANS	0.83573492	5.00E-33
THYM	Cell metabolism gene	RPS2	PSMC3	0.836232863	4.24E-33
THYM	Cell metabolism gene	RPS2	TOMM22	0.838684176	1.85E-33
THYM	Cell metabolism gene	RPS2	GEMIN7	0.840331027	1.05E-33
THYM	Cell metabolism gene	RPS2	SSR2	0.845389697	1.79E-34
THYM	Cell metabolism gene	RPS2	ACOT8	0.846156873	1.36E-34
THYM	Cell metabolism gene	RPS2	TOMM40	0.851421438	1.98E-35
THYM	Cell metabolism gene	RPS2	EBP	0.851589866	1.86E-35
THYM	Cell metabolism gene	RPS2	DPM2	0.852763739	1.20E-35
THYM	Cell metabolism gene	RPS2	MTX1	0.854852041	5.44E-36
THYM	Cell metabolism gene	RPS2	POLR2F	0.855394454	4.42E-36
THYM	Cell metabolism gene	RPS2	SRM	0.85670503	2.67E-36
THYM	Cell metabolism gene	RPS2	GEMIN6	0.859597784	8.58E-37
THYM	Cell metabolism gene	RPS2	PSMB7	0.860570365	5.83E-37
THYM	Cell metabolism gene	RPS2	SLC27A5	0.86288147	2.30E-37
THYM	Cell metabolism gene	RPS2	PSMB3	0.865315806	8.46E-38
THYM	Cell metabolism gene	RPS2	ITPA	0.866788108	4.58E-38
THYM	Cell metabolism gene	RPS2	PFDN5	0.870378162	9.93E-39
THYM	Cell metabolism gene	RPS2	EXOSC4	0.871728023	5.53E-39
THYM	Cell metabolism gene	RPS2	POLR2H	0.872562707	3.83E-39
THYM	Cell metabolism gene	RPS2	TIMM13	0.87438291	1.71E-39
THYM	Cell metabolism gene	RPS2	APRT	0.879168491	1.93E-40
THYM	Cell metabolism gene	RPS2	TIMM50	0.879497153	1.65E-40
THYM	Cell metabolism gene	RPS2	PGLS	0.881498397	6.44E-41
THYM	Cell metabolism gene	RPS2	POLR2I	0.886145717	6.74E-42
THYM	Cell metabolism gene	RPS2	HMBS	0.889261925	1.40E-42
THYM	Cell metabolism gene	RPS2	EXOSC5	0.891283704	4.94E-43
THYM	Cell metabolism gene	RPS2	SNRPD2	0.893341518	1.67E-43
THYM	Cell metabolism gene	RPS2	TIMM8B	0.907200893	6.02E-47
THYM	Cell metabolism gene	RPS2	FAU	0.921872615	3.07E-51
THYM	CGC	RPS2	ASPSCR1	0.805494121	4.84E-29
THYM	CGC	RPS2	MGMT	0.80794284	2.45E-29
THYM	CGC	RPS2	TFPT	0.810312824	1.25E-29
THYM	CGC	RPS2	RBM10	0.817201994	1.70E-30
THYM	CGC	RPS2	SDHAF2	0.831196182	2.22E-32
THYM	Epifactor	RPS2	RRP8	0.807534086	2.75E-29
THYM	Epifactor	RPS2	TFPT	0.810312824	1.25E-29
THYM	Epifactor	RPS2	LAS1L	0.812043988	7.65E-30
THYM	Epifactor	RPS2	EXOSC1	0.812642429	6.44E-30
THYM	Epifactor	RPS2	PPP4C	0.823581339	2.47E-31
THYM	Epifactor	RPS2	PRMT1	0.825398143	1.40E-31
THYM	Epifactor	RPS2	RUVBL2	0.828065939	6.07E-32
THYM	Epifactor	RPS2	CCDC101	0.828451252	5.37E-32
THYM	Epifactor	RPS2	C17orf49	0.82986767	3.41E-32
THYM	Epifactor	RPS2	PRPF31	0.852067207	1.56E-35
THYM	Epifactor	RPS2	ZNHIT1	0.856047956	3.44E-36
THYM	Epifactor	RPS2	NOC2L	0.857465332	1.98E-36
THYM	Epifactor	RPS2	INO80E	0.87063712	8.88E-39
THYM	Epifactor	RPS2	EXOSC4	0.871728023	5.53E-39
THYM	Epifactor	RPS2	BRMS1	0.887183012	4.02E-42
THYM	Epifactor	RPS2	SIRT6	0.888406699	2.17E-42
THYM	Epifactor	RPS2	EXOSC5	0.891283704	4.94E-43
THYM	Epifactor	RPS2	FBL	0.900529628	3.16E-45
THYM	Epifactor	RPS2	TAF10	0.904963027	2.35E-46
THYM	IUPHAR	RPS2	PTGES2	0.804618644	6.17E-29
THYM	IUPHAR	RPS2	PPIA	0.805359608	5.03E-29
THYM	IUPHAR	RPS2	MPST	0.811072634	1.01E-29
THYM	IUPHAR	RPS2	IMPDH2	0.825317735	1.44E-31
THYM	IUPHAR	RPS2	PRMT1	0.825398143	1.40E-31
THYM	IUPHAR	RPS2	PHKG2	0.830976464	2.39E-32
THYM	IUPHAR	RPS2	SLC27A5	0.86288147	2.30E-37
THYM	IUPHAR	RPS2	SIRT6	0.888406699	2.17E-42
THYM	Kinase	RPS2	PHKG2	0.830976464	2.39E-32
THYM	TF	RPS2	NME2	0.801327495	1.51E-28
THYM	TF	RPS2	ZNF32	0.801928705	1.29E-28
THYM	TF	RPS2	THAP3	0.803571114	8.22E-29
THYM	TF	RPS2	DRAP1	0.803700865	7.93E-29
THYM	TF	RPS2	ZNF668	0.810430919	1.21E-29
THYM	TF	RPS2	REXO4	0.810443839	1.21E-29
THYM	TF	RPS2	GLI4	0.811680911	8.49E-30
THYM	TF	RPS2	ZBTB48	0.820743776	5.87E-31
THYM	TF	RPS2	THAP7	0.829855916	3.43E-32
THYM	TF	RPS2	ZNF428	0.833206818	1.15E-32
THYM	TF	RPS2	ZNF688	0.847829807	7.43E-35
THYM	TF	RPS2	ZNF511	0.852238535	1.46E-35
THYM	TF	RPS2	ZNF581	0.880023658	1.29E-40
THYM	TF	RPS2	ZNF787	0.884371798	1.61E-41
THYM	TSG	RPS2	ST20	0.800293805	2.00E-28
THYM	TSG	RPS2	GABARAP	0.803050102	9.47E-29
THYM	TSG	RPS2	STUB1	0.803909333	7.49E-29
THYM	TSG	RPS2	ZNF668	0.810430919	1.21E-29
THYM	TSG	RPS2	NME1	0.811768616	8.28E-30
THYM	TSG	RPS2	ZBTB48	0.820743776	5.87E-31
THYM	TSG	RPS2	PARK7	0.839922807	1.21E-33
THYM	TSG	RPS2	NPRL2	0.849985276	3.38E-35
THYM	TSG	RPS2	GLTSCR2	0.851411288	1.99E-35
THYM	TSG	RPS2	TSSC4	0.853427904	9.35E-36
THYM	TSG	RPS2	GNB2L1	0.869830096	1.26E-38
THYM	TSG	RPS2	GADD45GIP1	0.885186594	1.08E-41
THYM	TSG	RPS2	BRMS1	0.887183012	4.02E-42
THYM	TSG	RPS2	SIRT6	0.888406699	2.17E-42
UCS	Cell metabolism gene	RPS2	DOHH	0.800019586	2.15E-28
UCS	Cell metabolism gene	RPS2	DGKZ	0.800230782	2.03E-28
UCS	Cell metabolism gene	RPS2	NME2	0.801327495	1.51E-28
UCS	Cell metabolism gene	RPS2	TIMM17B	0.801428096	1.47E-28
UCS	Cell metabolism gene	RPS2	SNRPE	0.802892407	9.89E-29
UCS	Cell metabolism gene	RPS2	TSTA3	0.803249692	8.97E-29
UCS	Cell metabolism gene	RPS2	LSM2	0.803914848	7.48E-29
UCS	Cell metabolism gene	RPS2	PTGES2	0.804618644	6.17E-29
UCS	Cell metabolism gene	RPS2	TBCB	0.806840154	3.33E-29
UCS	Cell metabolism gene	RPS2	ATP5G1	0.80725882	2.97E-29
UCS	Cell metabolism gene	RPS2	LSM4	0.808206202	2.28E-29
UCS	Cell metabolism gene	RPS2	ALG3	0.808818477	1.92E-29
UCS	Cell metabolism gene	RPS2	MPST	0.811072634	1.01E-29
UCS	Cell metabolism gene	RPS2	PSMD13	0.811239076	9.63E-30
UCS	Cell metabolism gene	RPS2	NME1	0.811768616	8.28E-30
UCS	Cell metabolism gene	RPS2	LCMT1	0.812408231	6.89E-30
UCS	Cell metabolism gene	RPS2	EXOSC1	0.812642429	6.44E-30
UCS	Cell metabolism gene	RPS2	PSMC5	0.816545344	2.06E-30
UCS	Cell metabolism gene	RPS2	GUK1	0.816631224	2.01E-30
UCS	Cell metabolism gene	RPS2	PSME2	0.817641045	1.49E-30
UCS	Cell metabolism gene	RPS2	SNRPD3	0.818825375	1.05E-30
UCS	Cell metabolism gene	RPS2	DGUOK	0.819647352	8.18E-31
UCS	Cell metabolism gene	RPS2	IMPDH2	0.825317735	1.44E-31
UCS	Cell metabolism gene	RPS2	MIF	0.825621597	1.31E-31
UCS	Cell metabolism gene	RPS2	GMPPA	0.825884872	1.21E-31
UCS	Cell metabolism gene	RPS2	WBSCR22	0.828864934	4.71E-32
UCS	Cell metabolism gene	RPS2	DPM3	0.829264399	4.14E-32
UCS	Cell metabolism gene	RPS2	PHKG2	0.830976464	2.39E-32
UCS	Cell metabolism gene	RPS2	TIMM10	0.831417087	2.07E-32
UCS	Cell metabolism gene	RPS2	POLR2J	0.831447126	2.05E-32
UCS	Cell metabolism gene	RPS2	PSMD4	0.832534911	1.44E-32
UCS	Cell metabolism gene	RPS2	PMPCA	0.835558205	5.31E-33
UCS	Cell metabolism gene	RPS2	NANS	0.83573492	5.00E-33
UCS	Cell metabolism gene	RPS2	PSMC3	0.836232863	4.24E-33
UCS	Cell metabolism gene	RPS2	TOMM22	0.838684176	1.85E-33
UCS	Cell metabolism gene	RPS2	GEMIN7	0.840331027	1.05E-33
UCS	Cell metabolism gene	RPS2	SSR2	0.845389697	1.79E-34
UCS	Cell metabolism gene	RPS2	ACOT8	0.846156873	1.36E-34
UCS	Cell metabolism gene	RPS2	TOMM40	0.851421438	1.98E-35
UCS	Cell metabolism gene	RPS2	EBP	0.851589866	1.86E-35
UCS	Cell metabolism gene	RPS2	DPM2	0.852763739	1.20E-35
UCS	Cell metabolism gene	RPS2	MTX1	0.854852041	5.44E-36
UCS	Cell metabolism gene	RPS2	POLR2F	0.855394454	4.42E-36
UCS	Cell metabolism gene	RPS2	SRM	0.85670503	2.67E-36
UCS	Cell metabolism gene	RPS2	GEMIN6	0.859597784	8.58E-37
UCS	Cell metabolism gene	RPS2	PSMB7	0.860570365	5.83E-37
UCS	Cell metabolism gene	RPS2	SLC27A5	0.86288147	2.30E-37
UCS	Cell metabolism gene	RPS2	PSMB3	0.865315806	8.46E-38
UCS	Cell metabolism gene	RPS2	ITPA	0.866788108	4.58E-38
UCS	Cell metabolism gene	RPS2	PFDN5	0.870378162	9.93E-39
UCS	Cell metabolism gene	RPS2	EXOSC4	0.871728023	5.53E-39
UCS	Cell metabolism gene	RPS2	POLR2H	0.872562707	3.83E-39
UCS	Cell metabolism gene	RPS2	TIMM13	0.87438291	1.71E-39
UCS	Cell metabolism gene	RPS2	APRT	0.879168491	1.93E-40
UCS	Cell metabolism gene	RPS2	TIMM50	0.879497153	1.65E-40
UCS	Cell metabolism gene	RPS2	PGLS	0.881498397	6.44E-41
UCS	Cell metabolism gene	RPS2	POLR2I	0.886145717	6.74E-42
UCS	Cell metabolism gene	RPS2	HMBS	0.889261925	1.40E-42
UCS	Cell metabolism gene	RPS2	EXOSC5	0.891283704	4.94E-43
UCS	Cell metabolism gene	RPS2	SNRPD2	0.893341518	1.67E-43
UCS	Cell metabolism gene	RPS2	TIMM8B	0.907200893	6.02E-47
UCS	Cell metabolism gene	RPS2	FAU	0.921872615	3.07E-51
UCS	CGC	RPS2	ASPSCR1	0.805494121	4.84E-29
UCS	CGC	RPS2	MGMT	0.80794284	2.45E-29
UCS	CGC	RPS2	TFPT	0.810312824	1.25E-29
UCS	CGC	RPS2	RBM10	0.817201994	1.70E-30
UCS	CGC	RPS2	SDHAF2	0.831196182	2.22E-32
UCS	Epifactor	RPS2	RRP8	0.807534086	2.75E-29
UCS	Epifactor	RPS2	TFPT	0.810312824	1.25E-29
UCS	Epifactor	RPS2	LAS1L	0.812043988	7.65E-30
UCS	Epifactor	RPS2	EXOSC1	0.812642429	6.44E-30
UCS	Epifactor	RPS2	PPP4C	0.823581339	2.47E-31
UCS	Epifactor	RPS2	PRMT1	0.825398143	1.40E-31
UCS	Epifactor	RPS2	RUVBL2	0.828065939	6.07E-32
UCS	Epifactor	RPS2	CCDC101	0.828451252	5.37E-32
UCS	Epifactor	RPS2	C17orf49	0.82986767	3.41E-32
UCS	Epifactor	RPS2	PRPF31	0.852067207	1.56E-35
UCS	Epifactor	RPS2	ZNHIT1	0.856047956	3.44E-36
UCS	Epifactor	RPS2	NOC2L	0.857465332	1.98E-36
UCS	Epifactor	RPS2	INO80E	0.87063712	8.88E-39
UCS	Epifactor	RPS2	EXOSC4	0.871728023	5.53E-39
UCS	Epifactor	RPS2	BRMS1	0.887183012	4.02E-42
UCS	Epifactor	RPS2	SIRT6	0.888406699	2.17E-42
UCS	Epifactor	RPS2	EXOSC5	0.891283704	4.94E-43
UCS	Epifactor	RPS2	FBL	0.900529628	3.16E-45
UCS	Epifactor	RPS2	TAF10	0.904963027	2.35E-46
UCS	IUPHAR	RPS2	PTGES2	0.804618644	6.17E-29
UCS	IUPHAR	RPS2	PPIA	0.805359608	5.03E-29
UCS	IUPHAR	RPS2	MPST	0.811072634	1.01E-29
UCS	IUPHAR	RPS2	IMPDH2	0.825317735	1.44E-31
UCS	IUPHAR	RPS2	PRMT1	0.825398143	1.40E-31
UCS	IUPHAR	RPS2	PHKG2	0.830976464	2.39E-32
UCS	IUPHAR	RPS2	SLC27A5	0.86288147	2.30E-37
UCS	IUPHAR	RPS2	SIRT6	0.888406699	2.17E-42
UCS	Kinase	RPS2	PHKG2	0.830976464	2.39E-32
UCS	TF	RPS2	NME2	0.801327495	1.51E-28
UCS	TF	RPS2	ZNF32	0.801928705	1.29E-28
UCS	TF	RPS2	THAP3	0.803571114	8.22E-29
UCS	TF	RPS2	DRAP1	0.803700865	7.93E-29
UCS	TF	RPS2	ZNF668	0.810430919	1.21E-29
UCS	TF	RPS2	REXO4	0.810443839	1.21E-29
UCS	TF	RPS2	GLI4	0.811680911	8.49E-30
UCS	TF	RPS2	ZBTB48	0.820743776	5.87E-31
UCS	TF	RPS2	THAP7	0.829855916	3.43E-32
UCS	TF	RPS2	ZNF428	0.833206818	1.15E-32
UCS	TF	RPS2	ZNF688	0.847829807	7.43E-35
UCS	TF	RPS2	ZNF511	0.852238535	1.46E-35
UCS	TF	RPS2	ZNF581	0.880023658	1.29E-40
UCS	TF	RPS2	ZNF787	0.884371798	1.61E-41
UCS	TSG	RPS2	ST20	0.800293805	2.00E-28
UCS	TSG	RPS2	GABARAP	0.803050102	9.47E-29
UCS	TSG	RPS2	STUB1	0.803909333	7.49E-29
UCS	TSG	RPS2	ZNF668	0.810430919	1.21E-29
UCS	TSG	RPS2	NME1	0.811768616	8.28E-30
UCS	TSG	RPS2	ZBTB48	0.820743776	5.87E-31
UCS	TSG	RPS2	PARK7	0.839922807	1.21E-33
UCS	TSG	RPS2	NPRL2	0.849985276	3.38E-35
UCS	TSG	RPS2	GLTSCR2	0.851411288	1.99E-35
UCS	TSG	RPS2	TSSC4	0.853427904	9.35E-36
UCS	TSG	RPS2	GNB2L1	0.869830096	1.26E-38
UCS	TSG	RPS2	GADD45GIP1	0.885186594	1.08E-41
UCS	TSG	RPS2	BRMS1	0.887183012	4.02E-42
UCS	TSG	RPS2	SIRT6	0.888406699	2.17E-42
UVM	Cell metabolism gene	RPS2	IMPDH2	0.823697963	6.57E-21
UVM	Cell metabolism gene	RPS2	MPST	0.829343509	2.07E-21
UVM	Cell metabolism gene	RPS2	SSR2	0.881811244	3.52E-27
UVM	Cell metabolism gene	RPS2	FAU	0.910196581	1.36E-31
UVM	CGC	RPS2	NACA	0.812690216	5.58E-20
UVM	CGC	RPS2	TRAF7	0.826842573	3.47E-21
UVM	Epifactor	RPS2	TRIM28	0.815835944	3.07E-20
UVM	Epifactor	RPS2	FBL	0.936933581	2.35E-37
UVM	IUPHAR	RPS2	TRIM28	0.815835944	3.07E-20
UVM	IUPHAR	RPS2	IMPDH2	0.823697963	6.57E-21
UVM	IUPHAR	RPS2	MPST	0.829343509	2.07E-21
UVM	Kinase	RPS2	TRIM28	0.815835944	3.07E-20
UVM	TF	RPS2	REXO4	0.817004229	2.45E-20
UVM	TF	RPS2	ZNF581	0.876723798	1.65E-26
UVM	TSG	RPS2	GLTSCR2	0.888028004	4.83E-28
UVM	TSG	RPS2	GNB2L1	0.918860141	3.08E-33

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS2	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS2	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS2	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPS2	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS2	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS2	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS2	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS2	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS2	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS2	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS2	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPS2	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS2	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS2	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS2	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS2	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPS2	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS2	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPS2	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPS2	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS2	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS2	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS2	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS2	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPS2	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPS2	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS2	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS2	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS2

MPP3, PRMT3, MEPCE, RUVBL2, SRRM2, TERF1, POT1, RBM39, DYRK2, STAU1, EBNA-LP, DNM2, GABARAPL2, GSK3B, GRB7, TK1, CDKN1A, SMN1, ANXA7, GADD45A, VHL, RAD21, FGF3, Fgf1, Fgf3, ARRB1, SIRT7, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, RPS4X, RPL10A, RPL10, RPL11, RPL12, RPL13, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL24, RPL30, RPL31, RPL37A, RPL3, RPL4, RPL5, RPL6, RPL7A, RPL7, RPL8, RPL9, RPS12, RPS13, RPS14, RPS16, RPS19, RPS25, RPS3, RPS5, RPS7, RPS8, RPS6, RPS3A, RPS23, RPS15, RPS20, RPS17, RPSA, RPS11, RPL23, RPLP1, RPL23A, RPS15A, RPS26, RPS28, RPL27, RPS10, RPS24, RPLP0, RPLP2, RPL22, RPS9, RPL27A, RPL38, RPL17, RPL32, RPS27A, RPS21, RPL29, FAU, EEF1A1, EEF2, ILF3, FBL, NOP56, NCL, SLC25A5, ILF2, MYBBP1A, HNRNPU, HSP90AB1, EEF1B2, TUFM, NHP2L1, HNRNPM, U2AF1, RPS27L, RPL10L, RPLP0P6, PTRH2, NENF, ANP32E, NOP2, NDUFS4, ATP6V0A2, TIMM10, RHOT2, UQCRB, MRPL12, NIFK, GNB2L1, SLC25A4, ATP5B, ATP5F1, MRPL23, ESR1, MAGOH, EIF4A3, FN1, VCAM1, UBL4A, ITGA4, SF3B1, PAN2, CD81, IGSF8, ICAM1, BAG3, SOX5, TARDBP, PARK2, EIF3E, RPS18, DDX3X, DYNLL1, EIF3CL, RPL28, RPS29, SND1, TSR1, WIBG, rev, CEP250, NEDD1, TP53, TUBG1, TUBGCP3, CUL7, OBSL1, CCDC8, RNF2, LARP7, RPL26L1, YBX1, YBX2, KNOP1, GTF3C2, ZNF574, ZNF324, C1QBP, GPRASP2, STAU2, HNRNPR, NAT10, TRO, RRP12, ZCRB1, KRI1, NOL9, NOM1, LTV1, UTP23, YBEY, U2SURP, TEX10, DHX57, LARP1B, NOL10, GTF3C1, SIRT1, AATF, ZSCAN25, PDCD2L, LLPH, PDCD2, UTP3, KRR1, DDX18, TOE1, CHERP, COPRS, MOV10, DICER1, ZNF496, CLNS1A, HERC5, PRKRIR, ZNF771, DUSP11, RIOK1, FCF1, SMARCA1, MPHOSPH10, PELP1, H2AFX, HIST1H2AG, SF3B4, PPAN-P2RY11, SRSF5, NGDN, ANGEL2, ZNF277, ASCC3, SMN2, RAD18, TCF25, NOB1, PURB, REPIN1, PRR3, MRPL52, NAP1L5, RPS6KB2, NTRK1, ATP6V0D1, MRPL22, MRPS10, MRPS11, RPL13A, RPL35A, RPL3L, MRPL15, MRPL4, MRPS14, RPL34, RPL35, RPL36, LOC101929876, RPS27, UBA52, SFN, PTEN, gag, XPO1, AHSA1, NPM1, Eif3a, Eif3e, Rpl35, Srp72, Rrbp1, Rcc1, Fbxo21, GAN, CRY2, NF2, Mdm2, ESRRB, CDC37, RC3H1, ZNF746, CDH1, RRS1, HIST1H1E, HIST1H1A, TOR1AIP2, CYLD, EIF2AK2, INO80B, TRIM25, BRCA1, LMNA, ZNF598, FBXO7, TMPO, WDR77, JUP, PCBP1, ACO2, API5, CTNNB1, DDX39B, DIMT1, TRIP4, UBE2M, PYHIN1, TRAF6, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, CHD4, SPDL1, HEXIM1, PPT1, SNAI1, AGR2, RECQL4, ANXA2, GPC1, REST, MYC, CDK9, Prkaa1, Prkab1, GRWD1, KRT17, METTL14, KIAA1429, RC3H2, ACTC1, PHB, NR2C2, PPP1CC, CTCF, KRAS, ATXN3, RPL26, VRK1, HIST1H4A, SNRNP70, ITFG1, HMGB1, BIRC3, NFX1, WWP2, BRD7, MATR3, TRIM28, TEX101, CMTR1, ARIH2, PLEKHA4, YAP1, TFCP2, FANCD2, HCVgp1, nsp1, ZC3H18, EMC4, SNIP1, ANKRD55, FAM120A, RBM47, IGF2BP1, NEK4, DUX4L9, DUX4, CIT, ANLN, AURKB, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, LRRC59, INS, NMRAL1, NDN, BRD4, CIC, N, Apc2, FBP1, MKRN1, LGALS9, MDM2, IFI16, USP47, RIN3, OGT, BAG5, SPOP, UFL1, DDRGK1, POLR2C, ATG10, USP15, WDR5, PAGE4, NAA40, HIST3H2BB, RPSAP58, SURF6, H1FNT, FGF13, ZNF668, RSL1D1, GLI4, DDX21, H2AFB2, NOTCH2, HIST1H1C, MAGEB2, HIST1H1D, BEND3, HIST1H1B, SRSF6, LIN28A, YTHDF1, RPS4Y2, ZFR, NKRF, TRUB2, CBX6, PAPD5, DHX30, ZNF317, BMS1, NEIL1, ZCCHC3, LARP1, GNL2, DDX24, CEBPZ, DKC1, CCDC137, IGF2BP3, RSBN1L, RIOK3, ZKSCAN8, FAM111A, PRKRA, PRPF4B, DHX37, RBM34, HIST2H2AB, APOBEC3B, SPATS2L, IMP3, ZC3HAV1, NSA2, SF3B2, ZNF22, RBM42, ZC3H8, PTCD1, GLYR1, SREK1, WHSC1, ZNF770, RBM17, COIL, DDX27, RPL7L1, DDX10, ZBTB11, HIST2H2AC, ABT1, HIST1H2AM, NOL12, DDX56, FGFBP1, ZFP91, RBM19, PAK1IP1, ZNF512, ZNF346, SMURF2, RSBN1, SF3B5, GLTSCR2, SSB, YBX3, DHX36, GTPBP4, MRPL27, C1orf35, ZNF768, FAM111B, HJURP, RPF1, TTF1, HIST1H1T, OASL, CYBA, FARS2, SPRTN, USP11, BTF3, TRIM26, FBXW7, UBR5, FXR2, FGD5, RCHY1, CCNF, CALCOCO2, SIRT6, PSMD9, RB1CC1, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPS2	chr16	2014289	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS2	chr16	2014489	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS2	BRCA	chr16	2014292	2014292	G	T	Missense_Mutation	p.F84L	3
RPS2	SKCM	chr16	2012222	2012222	G	A	Silent	p.P253P	3
RPS2	THYM	chr16	2012130	2012130	C	T	Missense_Mutation	p.R284Q	3
RPS2	LIHC	chr16	2013233	2013233	G	A	Silent		2
RPS2	BLCA	chr16	2012182	2012182	G	A	Nonsense_Mutation	p.Q267*	2
RPS2	THYM	chr16	2012130	2012130	C	T	Missense_Mutation		2
RPS2	SKCM	chr16	2012119	2012119	G	A	Missense_Mutation	p.P288S	2
RPS2	KIRP	chr16	2014483	2014484	-	CGGCCT	In_Frame_Ins	p.R48delinsRGR	2
RPS2	UCEC	chr16	2012222	2012222	G	A	Silent	p.P253	2
RPS2	COAD	chr16	2014591	2014591	C	T	Silent	p.G12G	2
RPS2	UCEC	chr16	2012499	2012499	G	A	Silent	p.F236	2
RPS2	LGG	chr16	2014319	2014319	G	C	Missense_Mutation	p.I75M	2
RPS2	ACC	chr16	2013252	2013252	T	C	Silent	p.S91S	2
RPS2	LGG	chr16	2014319	2014319	G	C	Missense_Mutation		2
RPS2	ESCA	chr16	2012170	2012170	C	T	Missense_Mutation	p.D271N	1
RPS2	THCA	chr16	2013180	2013180	C	A	Missense_Mutation	p.Q85H	1
RPS2	BLCA	chr16	2014322	2014322	C	T	Silent		1
RPS2	BLCA	chr16	2012818	2012818	G	A	Silent	p.I156I	1
RPS2	SARC	chr16	2012550	2012550	G	A	Silent		1
RPS2	ESCA	chr16	2014594	2014594	G	T	Silent	p.P11P	1
RPS2	THYM	chr16	2012773	2012773	C	T	Silent		1
RPS2	LIHC	chr16	2012581	2012581	A	G	Missense_Mutation	p.V209A	1
RPS2	SARC	chr16	2012550	2012550	G	A	Silent	p.I189I	1
RPS2	HNSC	chr16	2012495	2012495	T	C	Missense_Mutation		1
RPS2	BLCA	chr16	2012571	2012571	C	T	Silent	p.K182K	1
RPS2	LIHC	chr16	2013233	2013233	G	A	Silent	p.L98L	1
RPS2	CESC	chr16	2012214	2012214	C	T	Missense_Mutation		1
RPS2	KIRC	chr16	2012906	2012906	A	T	Missense_Mutation	p.F127Y	1
RPS2	BLCA	chr16	2012818	2012818	G	A	Silent	p.I126I	1
RPS2	LIHC	chr16	2014607	2014607	G	T	Missense_Mutation	p.A7E	1
RPS2	CESC	chr16	2012214	2012214	C	T	Nonsense_Mutation	p.W256*	1
RPS2	KIRC	chr16	2012906	2012906	A	T	Missense_Mutation	p.F97Y	1
RPS2	THYM	chr16	2012627	2012627	G	T	Missense_Mutation	p.R164S	1
RPS2	BLCA	chr16	2014478	2014478	G	A	Missense_Mutation	p.A50V	1
RPS2	LIHC	chr16	2013233	2013233	G	A	Silent	p.L68L	1
RPS2	COAD	chr16	2012253	2012253	G	A	Missense_Mutation	p.A243V	1
RPS2	SKCM	chr16	2012881	2012881	G	A	Silent	p.G105G	1
RPS2	BLCA	chr16	2012533	2012533	G	A	Missense_Mutation	p.S195L	1
RPS2	LUAD	chr16	2012152	2012152	G	T	Missense_Mutation	p.H277N	1
RPS2	COAD	chr16	2012587	2012587	G	A	Missense_Mutation	p.A207V	1
RPS2	SKCM	chr16	2013234	2013234	G	A	Silent	p.F67F	1
RPS2	KIRP	chr16	2014483	2014484	-	CGGCCT	In_Frame_Ins	p.48_48R>RGR	1
RPS2	BLCA	chr16	2014461	2014461	C	T	Missense_Mutation	p.E56K	1
RPS2	LUAD	chr16	2013170	2013170	C	A	Missense_Mutation	p.G89C	1
RPS2	SKCM	chr16	2012607	2012607	C	T	Silent	p.R170R	1
RPS2	BLCA	chr16	2014322	2014322	C	T	Silent	p.K74K	1
RPS2	MESO	chr16	2014365	2014365	C	A	Missense_Mutation		1
RPS2	ESCA	chr16	2014594	2014594	G	T	Silent	p.P11	1
RPS2	SKCM	chr16	2012137	2012137	C	T	Missense_Mutation	p.V282M	1
RPS2	UCS	chr16	2013186	2013186	C	A	Missense_Mutation	p.Q83H	1
RPS2	LGG	chr16	2012755	2012755	G	A	Silent	p.P147P	1
RPS2	BLCA	chr16	2012198	2012198	G	T	Missense_Mutation	p.F261L	1
RPS2	PRAD	chr16	2014492	2014492	G	A	Silent	p.G45G	1
RPS2	ESCA	chr16	2014594	2014594	G	T	Silent		1
RPS2	STAD	chr16	2013224	2013224	A	G	Missense_Mutation	p.S101P	1
RPS2	ACC	chr16	2013252	2013252	T	C	Silent	p.S61S	1
RPS2	BLCA	chr16	2013172	2013172	G	A	Missense_Mutation	p.A88V	1
RPS2	READ	chr16	2012627	2012627	G	A	Missense_Mutation	p.R194C	1
RPS2	ESCA	chr16	2012170	2012170	C	T	Missense_Mutation		1
RPS2	STAD	chr16	2012162	2012162	G	A	Silent	p.L273L	1
RPS2	BLCA	chr16	2014461	2014461	C	T	Missense_Mutation		1
RPS2	LGG	chr16	2012755	2012755	G	A	Silent		1
RPS2	BLCA	chr16	2012571	2012571	C	T	Silent	p.K212K	1
RPS2	READ	chr16	2014528	2014528	G	A	Silent	p.I33I	1

Copy number variation (CNV) of RPS2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
95664	N/A	AA079031	AL136380.1	chr1	45309755	+	RPS2	chr16	2012062	+
95664	N/A	AA807941	AL136380.1	chr1	45309755	+	RPS2	chr16	2012066	+
95664	N/A	BG056152	CD99	chrY	2567530	+	RPS2	chr16	2012063	+
95664	N/A	BU594642	COX7A2	chr6	75953447	-	RPS2	chr16	2012274	-
95664	N/A	BI861854	GHR	chr5	42475009	+	RPS2	chr16	2012060	+
95664	N/A	EC458743	MFSD2A	chr1	40429050	-	RPS2	chr16	2012090	+
95664	PRAD	TCGA-KK-A8I7	PRKCB	chr16	24135302	+	RPS2	chr16	2013257	-
95664	COAD	TCGA-DM-A1D8	RPL18	chr19	49122397	-	RPS2	chr16	2013257	-
77866	N/A	AW023245	RPS2	chr16	2012059	-	GAB1	chr4	144270390	-
77866	N/A	BI858621	RPS2	chr16	2012063	-	GAB1	chr4	144270418	-
103075	N/A	BG033326	RPS2	chr16	1934483	-	HEG1	chr3	124621966	+
101214	N/A	AX395904	RPS2	chr16	2012254	+	HSP90AA1	chr14	102552228	-
96843	OV	TCGA-61-2102-01A	RPS2	chr16	2014509	-	IGF2	chr11	2160010	-
77866	LUSC	TCGA-22-1011	RPS2	chr16	2012589	-	IGHG1	chr14	106209411	-
77866	SKCM	TCGA-HR-A2OG-06A	RPS2	chr16	2012222	-	IGKC	chr2	89156828	-
100861	N/A	AI360931	RPS2	chr16	2012912	+	TAOK3	chr12	118684807	-
100861	N/A	BF337579	RPS2	chr16	2012504	-	TAOK3	chr12	118683879	+
95664	N/A	BG222509	TAOK3	chr12	118684279	-	RPS2	chr16	2012062	+
95664	N/A	EC574343	TENM4	chr11	78825875	-	RPS2	chr16	2012820	-
95665	STAD	TCGA-CG-5721-01A	TYMP	chr22	50966941	-	RPS2	chr16	2013257	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
ACC	RPS2	2.55160652735101	0.936723171522778	0.000725021157838113	0.000528434350059149	0.000628482878383333	79
LGG	RPS2	0.622072932539694	-0.474697938229806	0.00112903454911075	0.000985727333214877	0.00127516524588861	525
LGG	RPS2	0.587965642865637	-0.531086763291255	0.00228547249323276	0.00154669103708249	0.00259198366218538	525
UVM	RPS2	0.377334667611658	-0.974622772820071	0.00343439658264843	0.00352491829498603	0.00249949680473587	80
LGG	RPS2	0.632649819860235	-0.457838217085331	0.00376671257450818	0.0033073326546468	0.00400135327017546	525
ACC	RPS2	1.23889246734593	0.2142178090064	0.00631841022567135	0.00583298297403561	0.00474114457826651	79
BRCA	RPS2	0.746630383600523	-0.292185017374015	0.00636735196811342	0.00571838956470157	0.00651534443079952	1200
ACC	RPS2	2.30219991814692	0.833865151944536	0.00773089611874281	0.00657931787727548	0.00661899359829933	79
UVM	RPS2	0.416302390235806	-0.876343383179131	0.00904041731666695	0.00768585395540361	0.00731734231516168	80
READ	RPS2	0.334253811382432	-1.09585466027547	0.00924217642921869	0.00586136427508007	0.00904931711123996	103
KIRC	RPS2	1.34415947380395	0.295768891166012	0.0119587244250217	0.0129408394564957	0.0119693179114138	604
KIRC	RPS2	1.34415947380395	0.295768891166012	0.0119587244250217	0.0129408394564957	0.0119693179114138	604
BRCA	RPS2	0.793696125492476	-0.231054604474045	0.012307635521318	0.0111646559218426	0.0123844151325613	1200
UVM	RPS2	3.10403142999533	1.13270172791253	0.0123787628202931	0.01417153594894	0.011341467776747	80
LIHC	RPS2	0.779544274496008	-0.249045793513566	0.0128735348313033	0.0132351943238359	0.0128788790709431	417
LIHC	RPS2	0.779544274496008	-0.249045793513566	0.0128735348313033	0.0132351943238359	0.0128788790709431	417
BRCA	RPS2	0.753983165791392	-0.282385237760037	0.013260826647489	0.012946666811755	0.0134278368010272	1200
LGG	RPS2	0.911941387597321	-0.0921795589584746	0.0144146360154868	0.0144733724883198	0.0138362581397383	525
KIRP	RPS2	1.72038383055724	0.542547423230197	0.0163273079529358	0.019004487831605	0.0162056786796444	320
KIRP	RPS2	1.72038383055724	0.542547423230197	0.0163273079529358	0.019004487831605	0.0162056786796444	320
SKCM	RPS2	1.06193007551233	0.0600880783849428	0.0183475635202314	0.016145841289317	0.0178949658362809	462
SKCM	RPS2	1.06193007551233	0.0600880783849428	0.0183475635202314	0.016145841289317	0.0178949658362809	462
THCA	RPS2	0.796090241311642	-0.228042731081513	0.0205446302208369	0.0238030000951957	0.0163842109460447	571
THCA	RPS2	0.796090241311642	-0.228042731081513	0.0205446302208369	0.0238030000951957	0.0163842109460447	571
ACC	RPS2	1.70962845876856	0.536276071332872	0.0213802812058327	0.0229118705883754	0.0195670099760737	79
UVM	RPS2	0.47401519073914	-0.746515909827717	0.0222160603803982	0.020463587734303	0.0193762773732592	80
LAML	RPS2	0.660278810084806	-0.415093093641686	0.0236466312514939	0.0241830927389988	0.0249362097374106	160
ACC	RPS2	1.82999653828322	0.604314075203028	0.0237368658202674	0.0295224464788412	0.0243307068842415	79
CESC	RPS2	1.40683402346902	0.34134180633307	0.0283042001243545	0.0298930426579737	0.0284344491091434	295
KIRP	RPS2	1.20887478500234	0.189689997205598	0.0294307784512635	0.0207372218471405	0.0272630494534294	320
KIRP	RPS2	1.20887478500234	0.189689997205598	0.0294307784512635	0.0207372218471405	0.0272630494534294	320
HNSC	RPS2	0.953803234656169	-0.0472978817878766	0.0310953460197635	0.0329026032057611	0.0307241453156578	562
COAD	RPS2	0.92418216525158	-0.0788460782310016	0.0404491772812382	0.0424367253001431	0.0389637008467234	315
COAD	RPS2	0.92418216525158	-0.0788460782310016	0.0404491772812382	0.0424367253001431	0.0389637008467234	315
KIRP	RPS2	1.51849603994679	0.417720397628544	0.0433002032988225	0.0495177194996435	0.0431250747409626	320
KIRP	RPS2	1.51849603994679	0.417720397628544	0.0433002032988225	0.0495177194996435	0.0431250747409626	320
SARC	RPS2	1.29988083337536	0.262272593631512	0.0434909288538031	0.0453793354150943	0.0436726362415723	265
LGG	RPS2	0.437435266893376	-0.826826545518403	2.19865917868265e-08	2.66631789248416e-08	2.22319552613134e-08	525
KIRC	RPS2	1.41989232873833	0.35058104390616	2.30027354488674e-05	3.71225371878288e-05	2.19966477503069e-05	604
KIRC	RPS2	1.41989232873833	0.35058104390616	2.30027354488674e-05	3.71225371878288e-05	2.19966477503069e-05	604
LGG	RPS2	0.389713732914654	-0.942342827549233	3.2502204351858e-11	5.08619509440842e-11	4.29853175578164e-11	525
KIRC	RPS2	1.56842638463648	0.450072813939582	4.02903767568663e-05	5.37723656190072e-05	4.02675057253125e-05	604
KIRC	RPS2	1.56842638463648	0.450072813939582	4.02903767568663e-05	5.37723656190072e-05	4.02675057253125e-05	604
LGG	RPS2	0.451245026785886	-0.795744790368883	7.35946225927626e-07	5.82786475509625e-07	7.3953150430941e-07	525

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPS2	0.000259571739265131	0.0073
KIRP	RPS2	0.00360897768996956	0.097
SARC	RPS2	0.014353889079508	0.37
MESO	RPS2	0.0399477961700428	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	RPS2	0.0311121189765314	0.93
LUSC	RPS2	0.000607532688664088	0.019
BRCA	RPS2	0.00878187334102165	0.27
PAAD	RPS2	0.000321742697424695	0.011

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0004238	Atrial Fibrillation	1	CTD_human
C0235480	Paroxysmal atrial fibrillation	1	CTD_human