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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS3 (NCBI Gene ID:6188)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS3
	Gene ID: 6188
	Gene Symbol	RPS3
	Gene ID	6188
	Gene Name	ribosomal protein S3
	Synonyms	S3
	Cytomap	11q13.4
	Type of Gene	protein-coding
	Description	40S ribosomal protein S3IMR-90 ribosomal protein S3small ribosomal subunit protein uS3
	Modification date	20200327
	UniProtAcc	P23396

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS3	GO:0006979	response to oxidative stress	23911537
Hgene	RPS3	GO:0017148	negative regulation of translation	20217897
Hgene	RPS3	GO:0031397	negative regulation of protein ubiquitination	19656744
Hgene	RPS3	GO:0032079	positive regulation of endodeoxyribonuclease activity	18973764
Hgene	RPS3	GO:0042769	DNA damage response, detection of DNA damage	23911537
Hgene	RPS3	GO:0045739	positive regulation of DNA repair	23911537
Hgene	RPS3	GO:0061481	response to TNF agonist	20041225
Hgene	RPS3	GO:0070301	cellular response to hydrogen peroxide	23911537
Hgene	RPS3	GO:1901224	positive regulation of NIK/NF-kappaB signaling	20041225
Hgene	RPS3	GO:1902546	positive regulation of DNA N-glycosylase activity	15518571
Hgene	RPS3	GO:1905053	positive regulation of base-excision repair	18973764
Hgene	RPS3	GO:2001235	positive regulation of apoptotic signaling pathway	14988002

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS3	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS3[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS3	uS3/Rps3 controls fidelity of translation termination and programmed stop codon readthrough in co-operation with eIF3	31642471

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000524851	75111737	75111868	Frame-shift
ENST00000527446	75111737	75111868	Frame-shift
ENST00000524851	75113395	75113490	Frame-shift
ENST00000527446	75113395	75113490	Frame-shift
ENST00000531188	75113395	75113490	Frame-shift
ENST00000524851	75115063	75115251	Frame-shift
ENST00000527446	75115063	75115251	Frame-shift
ENST00000531188	75115063	75115251	Frame-shift
ENST00000531188	75115715	75115912	3UTR-3CDS

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
COAD	RPS3	1.48730375143014	0.000411599874496461
HNSC	RPS3	-4.73505819095135	0.0273726439852453
KIRC	RPS3	-1.29560847926387	9.05905681935088e-10

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
OV	RPS3	hsa-miR-328-3p	94	-0.369503969947921	0.00733517817158507

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
OV	RPS3	0.086517685	0.013295822
TGCT	RPS3	0.078257158	0.019533402
DLBC	RPS3	-0.017254099	0.044469696

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS3 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	RPS3	TIMM13	0.803398954	6.32E-12
DLBC	Cell metabolism gene	RPS3	TOMM22	0.810314537	3.01E-12
DLBC	Cell metabolism gene	RPS3	TIMM9	0.81479141	1.83E-12
DLBC	Cell metabolism gene	RPS3	PTDSS2	0.819974399	1.01E-12
DLBC	Cell metabolism gene	RPS3	PFDN5	0.830774657	2.75E-13
DLBC	Cell metabolism gene	RPS3	SNRPD2	0.848140688	2.78E-14
DLBC	Cell metabolism gene	RPS3	NME2	0.861502735	3.89E-15
DLBC	Cell metabolism gene	RPS3	FAU	0.903308052	1.60E-18
DLBC	CGC	RPS3	NACA	0.867183344	1.58E-15
DLBC	Epifactor	RPS3	FBL	0.838109777	1.08E-13
DLBC	IUPHAR	RPS3	SLC25A3	0.801424626	7.78E-12
DLBC	TF	RPS3	NME2	0.861502735	3.89E-15
DLBC	TSG	RPS3	GLTSCR2	0.813064973	2.22E-12
DLBC	TSG	RPS3	GNB2L1	0.888507622	3.59E-17
GBM	Cell metabolism gene	RPS3	SSR4	0.81760904	1.30E-42
GBM	Cell metabolism gene	RPS3	SNRPG	0.818115954	1.05E-42
GBM	Cell metabolism gene	RPS3	ZNRD1	0.818417003	9.27E-43
GBM	Cell metabolism gene	RPS3	CCT4	0.824690035	6.21E-44
GBM	Cell metabolism gene	RPS3	PFDN5	0.825761376	3.87E-44
GBM	Cell metabolism gene	RPS3	FAU	0.851026754	1.99E-49
GBM	Cell metabolism gene	RPS3	SSR2	0.856688211	9.53E-51
GBM	TSG	RPS3	GAS5	0.835902392	3.75E-46
KICH	Cell metabolism gene	RPS3	FAU	0.860997624	7.20E-28
KIRP	Epifactor	RPS3	FBL	0.821310446	3.07E-80
LGG	Cell metabolism gene	RPS3	IMPDH2	0.844414404	3.02E-145
LGG	Cell metabolism gene	RPS3	FAU	0.897471998	7.73E-190
LGG	CGC	RPS3	NACA	0.852004326	1.63E-150
LGG	IUPHAR	RPS3	IMPDH2	0.844414404	3.02E-145
LGG	TSG	RPS3	GAS5	0.842025027	1.20E-143
LGG	TSG	RPS3	GNB2L1	0.874595462	3.99E-168
LIHC	Epifactor	RPS3	FBL	0.820318061	3.23E-104
LIHC	TSG	RPS3	GNB2L1	0.816019629	2.86E-102
PAAD	Cell metabolism gene	RPS3	FAU	0.846113924	2.41E-51
PRAD	Cell metabolism gene	RPS3	TIMM9	0.816594013	6.79E-133
PRAD	Cell metabolism gene	RPS3	SNRPD2	0.834735264	4.08E-144
PRAD	Cell metabolism gene	RPS3	FAU	0.843536049	4.61E-150
PRAD	CGC	RPS3	NACA	0.865905073	5.36E-167
PRAD	Epifactor	RPS3	FBL	0.884104504	3.30E-183
PRAD	TF	RPS3	ZNF581	0.824720534	9.24E-138
PRAD	TSG	RPS3	GAS5	0.839807865	1.69E-147
PRAD	TSG	RPS3	GNB2L1	0.891692025	8.63E-191
THCA	Cell metabolism gene	RPS3	FAU	0.820987946	7.38E-141
THCA	TSG	RPS3	GNB2L1	0.817176525	1.65E-138
THYM	Cell metabolism gene	RPS3	PGLS	0.801176818	1.57E-28
THYM	Cell metabolism gene	RPS3	PSMD13	0.810046679	1.35E-29
THYM	Cell metabolism gene	RPS3	LSM2	0.811696596	8.45E-30
THYM	Cell metabolism gene	RPS3	PSMC3	0.826020077	1.16E-31
THYM	Cell metabolism gene	RPS3	TIMM8B	0.834358905	7.90E-33
THYM	Cell metabolism gene	RPS3	TIMM13	0.83606725	4.48E-33
THYM	Cell metabolism gene	RPS3	IMPDH2	0.850191146	3.13E-35
THYM	Cell metabolism gene	RPS3	PFDN5	0.852819374	1.18E-35
THYM	Cell metabolism gene	RPS3	SNRPD2	0.854221446	6.92E-36
THYM	Cell metabolism gene	RPS3	TALDO1	0.857193193	2.21E-36
THYM	Cell metabolism gene	RPS3	SLC27A5	0.857998764	1.61E-36
THYM	Cell metabolism gene	RPS3	SSR2	0.87573555	9.31E-40
THYM	Cell metabolism gene	RPS3	FAU	0.917216502	8.61E-50
THYM	CGC	RPS3	SDHAF2	0.816722505	1.96E-30
THYM	Epifactor	RPS3	MBD3	0.814685178	3.56E-30
THYM	Epifactor	RPS3	BRMS1	0.834973065	6.45E-33
THYM	Epifactor	RPS3	TAF10	0.84382444	3.12E-34
THYM	Epifactor	RPS3	NOC2L	0.853390926	9.48E-36
THYM	Epifactor	RPS3	FBL	0.903737137	4.88E-46
THYM	IUPHAR	RPS3	MFSD2B	0.827590057	7.05E-32
THYM	IUPHAR	RPS3	IMPDH2	0.850191146	3.13E-35
THYM	IUPHAR	RPS3	SLC27A5	0.857998764	1.61E-36
THYM	TF	RPS3	ZNF581	0.812048986	7.64E-30
THYM	TF	RPS3	THAP3	0.813943511	4.42E-30
THYM	TF	RPS3	MBD3	0.814685178	3.56E-30
THYM	TF	RPS3	REXO4	0.815590169	2.73E-30
THYM	TF	RPS3	ZNF408	0.816701686	1.97E-30
THYM	TSG	RPS3	BRMS1	0.834973065	6.45E-33
THYM	TSG	RPS3	TSSC4	0.856204206	3.24E-36
THYM	TSG	RPS3	GLTSCR2	0.866996268	4.19E-38
THYM	TSG	RPS3	GNB2L1	0.892937409	2.07E-43
UCS	Cell metabolism gene	RPS3	PGLS	0.801176818	1.57E-28
UCS	Cell metabolism gene	RPS3	PSMD13	0.810046679	1.35E-29
UCS	Cell metabolism gene	RPS3	LSM2	0.811696596	8.45E-30
UCS	Cell metabolism gene	RPS3	PSMC3	0.826020077	1.16E-31
UCS	Cell metabolism gene	RPS3	TIMM8B	0.834358905	7.90E-33
UCS	Cell metabolism gene	RPS3	TIMM13	0.83606725	4.48E-33
UCS	Cell metabolism gene	RPS3	IMPDH2	0.850191146	3.13E-35
UCS	Cell metabolism gene	RPS3	PFDN5	0.852819374	1.18E-35
UCS	Cell metabolism gene	RPS3	SNRPD2	0.854221446	6.92E-36
UCS	Cell metabolism gene	RPS3	TALDO1	0.857193193	2.21E-36
UCS	Cell metabolism gene	RPS3	SLC27A5	0.857998764	1.61E-36
UCS	Cell metabolism gene	RPS3	SSR2	0.87573555	9.31E-40
UCS	Cell metabolism gene	RPS3	FAU	0.917216502	8.61E-50
UCS	CGC	RPS3	SDHAF2	0.816722505	1.96E-30
UCS	Epifactor	RPS3	MBD3	0.814685178	3.56E-30
UCS	Epifactor	RPS3	BRMS1	0.834973065	6.45E-33
UCS	Epifactor	RPS3	TAF10	0.84382444	3.12E-34
UCS	Epifactor	RPS3	NOC2L	0.853390926	9.48E-36
UCS	Epifactor	RPS3	FBL	0.903737137	4.88E-46
UCS	IUPHAR	RPS3	MFSD2B	0.827590057	7.05E-32
UCS	IUPHAR	RPS3	IMPDH2	0.850191146	3.13E-35
UCS	IUPHAR	RPS3	SLC27A5	0.857998764	1.61E-36
UCS	TF	RPS3	ZNF581	0.812048986	7.64E-30
UCS	TF	RPS3	THAP3	0.813943511	4.42E-30
UCS	TF	RPS3	MBD3	0.814685178	3.56E-30
UCS	TF	RPS3	REXO4	0.815590169	2.73E-30
UCS	TF	RPS3	ZNF408	0.816701686	1.97E-30
UCS	TSG	RPS3	BRMS1	0.834973065	6.45E-33
UCS	TSG	RPS3	TSSC4	0.856204206	3.24E-36
UCS	TSG	RPS3	GLTSCR2	0.866996268	4.19E-38
UCS	TSG	RPS3	GNB2L1	0.892937409	2.07E-43
UVM	Cell metabolism gene	RPS3	POLR1D	0.85692449	3.71E-24
UVM	Cell metabolism gene	RPS3	FAU	0.861036528	1.29E-24
UVM	CGC	RPS3	NACA	0.831600923	1.29E-21
UVM	Epifactor	RPS3	FBL	0.891762343	1.38E-28
UVM	TSG	RPS3	GLTSCR2	0.869311101	1.39E-25
UVM	TSG	RPS3	GNB2L1	0.869982866	1.15E-25

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS3	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS3	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS3	RPS16	-1.35957043617517	0.00019507110118866
STAD	RPS3	RPS23	1.85076760664576	0.000364991836249828
KIRP	RPS3	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS3	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS3	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS3	RPL19	1.36901182894089	0.00250792503356934
ESCA	RPS3	BYSL	-1.41965432328034	0.0029296875
KICH	RPS3	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS3	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS3	RPS16	-6.16322798156577	0.0115764821363307
LUSC	RPS3	RPS23	1.46751169891047	0.0174932185880974
BLCA	RPS3	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS3	RPS27A	-1.04747470069188	0.0258216857910156
COAD	RPS3	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS3	RPL19	-2.14669889516666	0.044366810398747
UCEC	RPS3	RPS23	-2.03658159814007	0.046875
KIRC	RPS3	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS3	RPS12	-4.91239327478244	1.85340619742495e-09
STAD	RPS3	BYSL	-2.46996682866835	2.3283064365387e-09
KIRC	RPS3	RPL35	-1.06475238059392	2.72286325678163e-08
PRAD	RPS3	BYSL	-4.18834172449879	4.1396395841136e-09
HNSC	RPS3	BYSL	1.83007134227969	5.27545735167224e-05
KIRC	RPS3	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS3	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS3	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS3	BYSL	-3.72440272841362	7.85448425978448e-18
BRCA	RPS3	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRP	RPS3	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS3	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS3

RPL9, KHDRBS2, MEPCE, HSP90AA1, HSPA4, RELA, NFKB1, NFKBIA, CHAF1A, CDK5RAP3, Mapk13, YWHAQ, HDAC5, MDM2, TP53, RBM39, SUMO1, ube2i, PCK1, VHL, RAD21, NDRG1, ARRB2, PARD3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, NEDD8, vpr, PPP2R1A, MID1, CRK, TXNL4B, RPS4X, UBXN6, RPL10A, RPL21, RPL6, RPL7A, RPS3A, RPL4, RPL7, RPLP0, RPS9, RPL11, RPL12, RPL13, RPL14, RPL15, RPL17, RPL18A, RPL18, RPL19, RPL23A, RPL24, RPL37A, RPL3, RPL5, RPL8, RPS11, RPS15A, RPS16, RPS19, RPS23, RPS24, RPS26, RPS28, RPS2, RPS5, RPS6, RPS7, RPS8, RPSA, RPL27A, RPS10, RPS13, RPS25, RPS20, RPS14, RPL31, RPL23, RPS12, RPL30, RPLP2, RPL22, RPLP1, RPS17, RPS15, RPL32, RPL29, RPS27A, RPS21, RPS29, NOP56, UBA52, MYBBP1A, SLC25A5, FBL, HNRNPU, ILF3, ILF2, GNL3, TUFM, NHP2L1, HNRNPA1, NAP1L1, RPS27L, BYSL, TCP1, NME2, RPL10L, RPLP0P6, SND1, HIST1H2AD, HNRNPA0, MRPL23, CDC5L, ATP5A1, NIFK, MAT2A, CAD, HSPA5, SLC9A3R1, RPS10P5, NUDT21, TPM1, UPF1, ESR1, MAGOH, SMURF1, CCT2, YWHAE, BTK, FN1, VCAM1, CSNK2A1, NOS2, IL7R, UBL4A, ITGA4, US3, PAN2, PPID, CD81, IGSF8, ICAM1, FOLH1, ATP6V0D2, FBXO6, TARDBP, EIF3A, EIF3E, LARP1, DDX3X, DYNLL1, DYNLT3, EIF3CL, FAU, GNB2L1, PNO1, RPL28, RPS18, RPS27, SERBP1, WIBG, TSR1, TRAF2, STAU1, AURKA, CDC20, CEP250, CEP57, NEDD1, TUBG1, TUBGCP2, TUBGCP3, TUBGCP4, VCP, HUWE1, MOV10, NXF1, CUL7, CCDC8, EED, UBC, HIST1H1A, RPS6KB2, UNK, MRPL3, MRPS12, RPL13A, RPL26, RPL27, RPL35, RPL35A, RPL36, RPL37, RPL38, LOC101929876, EEFSEC, KRR1, RPL10, RPL34, SCD, SSB, SFN, NTRK1, MUS81, PTEN, gag, XPO1, AHSA1, CCNB1, NPM1, TSNAX, POLG2, IBTK, EXOSC4, Cbx1, Eif3a, Eif3e, Eif3i, Rpl35, Srp72, Rrbp1, Bag2, Nup188, Ccdc9, GAN, SKI, CRY1, CRY2, MCM2, NF2, Ksr1, ESRRB, RC3H1, CDC73, RNF20, EGFR, RRS1, H2AFX, HIST1H1E, DEFA5, CAPN8, PDGFB, SART3, ZCRB1, PRR11, DFNA5, FGF8, BHLHA15, DKK3, ZNF169, HIST1H1T, ZBTB48, NCL, WBP2, CYLD, INO80B, TRIM25, HEY1, BRCA1, MTF1, RNF169, HDAC6, ASCC3, ACLY, ZNF598, FBXO7, CBX4, CBX6, BMI1, PHC3, CTNNB1, DDX39B, ACO2, ADSS, BMP4, WDR77, HSPA8, TGFB1, TRIP4, BCL2L1, COPE, CSNK1A1, IGF1R, LARS, PIK3CA, PPP6C, YAP1, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, RNF4, CHD3, CHD4, RNF31, TNF, SPDL1, RIOK1, HEXIM1, LARP7, PPT1, SNAI1, AGR2, RECQL4, DCPS, REST, ZFP36L2, MYC, CDK9, Prkaa1, Prkab1, KRT17, METTL14, KIAA1429, EIF4B, DCAF13, RC3H2, RNF138, DDIT3, ESR2, PHB, FAF1, RBX1, USP14, NR2C2, UBQLN2, PPP1CC, PPARG, HDAC2, CTCF, PRMT7, AGRN, KRAS, ATXN3, VRK1, SNRNP70, ITFG1, HMGB1, PPP1CA, BIRC3, NFX1, WWP2, BRD7, Hsp22, Dnajc17, SOX2, TRIM28, LTV1, ARIH2, PLEKHA4, PINK1, TFCP2, FANCD2, HCVgp1, nsp1, TRIM6, ZC3H18, GOLGA3, ANKRD55, E, M, nsp13, nsp14, nsp4, nsp5, nsp6, ORF14, ORF3a, ORF6, ORF7a, ORF7b, S, NEK4, DUX4, DUX4L9, CIT, ANLN, AURKB, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, LRRC59, INS, NMRAL1, SUMO2, NDN, Rnf183, BRD4, RBM45, CIC, Apc2, FBP1, LGALS9, IFI16, BKRF1, INSIG2, RIN3, LXN, HECTD1, OGT, SPOP, AR, PARK2, UFL1, DDRGK1, COIL, MARCKS, TRAP1, TRIM37, FZR1, WDR5, PAGE4, NUDCD2, PPAN-P2RY11, RPSAP58, RPL26L1, ZNF689, ZNF273, DHX36, TOE1, CDK12, NAT10, ASCC2, SRBD1, H1FOO, NGDN, EPB41L5, USP42, BEND7, PRKRIR, FGF13, LIN28A, ZNF624, PURB, ZBTB11, RPL36AL, ZNF48, ZNF574, DNTTIP2, RBM10, HELZ2, YBX3, MPHOSPH10, GLE1, YTHDC2, ZNF791, SRSF6, YTHDF1, SRFBP1, HIST1H2AM, PATZ1, SYNCRIP, HNRNPR, DAXX, SREK1, C3orf17, DHX57, AATF, U2SURP, FARS2, TRIM71, DDX21, PWP2, PRDM10, ABT1, ZNF629, RSBN1, ZNF768, RBM5, H2AFB2, RRP7A, DHX8, ZNF346, BMS1, THAP3, LLPH, GRSF1, ZC3H8, H1FNT, DDX55, RBM17, RSL1D1, YBX1, HIST1H1D, RRP12, SRSF12, CDK13, IMP4, PDCD11, GZF1, ZCCHC17, ZKSCAN8, ZNF316, HDLBP, ZNF92, SCAF1, GNL2, ZNF638, ZNF445, NOL6, ZFP91, ISM2, ZNF777, LARP1B, HIST1H1C, H2AFB3, ZCCHC6, HP1BP3, HIST1H2AG, LYAR, PURG, CHERP, STAU2, YTHDC1, HIST1H1B, ZSCAN25, PRR3, RSBN1L, ZFR, ZBTB24, SRSF5, CCDC140, DDX10, NOL10, RBM19, KRI1, ZNF358, HIST2H2AC, FGF17, YBX2, PRDM15, STRBP, ZNF668, PURA, APOBEC3D, SRSF1, FGFBP1, HIST1H2AE, NEIL1, SPRTN, BTF3, TRIM26, NLRP7, FGD5, CDK1, CCNF, TOLLIP, PSMD9, RB1CC1, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPS3	chr11	75112681	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS3	PAAD	chr11	75115883	75115883	A	G	Missense_Mutation	p.M252V	3
RPS3	LGG	chr11	75115230	75115230	C	T	Missense_Mutation	p.R173C	3
RPS3	UCEC	chr11	75111796	75111796	C	A	Missense_Mutation	p.A30D	3
RPS3	LIHC	chr11	75110602	75110602	A	G	Missense_Mutation	p.Q4R	3
RPS3	UCEC	chr11	75115793	75115793	G	A	Missense_Mutation	p.D206N	2
RPS3	THYM	chr11	75113456	75113456	C	T	Missense_Mutation		2
RPS3	SARC	chr11	75111861	75111861	G	T	Missense_Mutation		2
RPS3	UCEC	chr11	75111792	75111792	C	T	Silent	p.L29	2
RPS3	HNSC	chr11	75115876	75115876	G	C	Missense_Mutation		2
RPS3	LIHC	chr11	75110602	75110602	A	G	Missense_Mutation		2
RPS3	UCEC	chr11	75113455	75113455	G	A	Silent	p.L105	2
RPS3	ACC	chr11	75115215	75115215	G	A	Missense_Mutation	p.V184I	2
RPS3	LIHC	chr11	75115172	75115172	G	A	Silent		2
RPS3	UCEC	chr11	75115080	75115080	C	T	Silent	p.L123	2
RPS3	UCEC	chr11	75115193	75115193	C	T	Silent	p.S160	2
RPS3	LUAD	chr11	75115797	75115797	A	G	Missense_Mutation	p.H207R	2
RPS3	KIRC	chr11	75113456	75113456	C	T	Missense_Mutation	p.R122C	2
RPS3	LIHC	chr11	75115747	75115747	G	T	Silent	p.L206L	1
RPS3	BLCA	chr11	75111510	75111510	C	T	Missense_Mutation		1
RPS3	LUAD	chr11	75113470	75113472	AGG	-	In_Frame_Del	p.LG110del	1
RPS3	KIRC	chr11	75113456	75113456	C	T	Missense_Mutation	p.R106C	1
RPS3	STAD	chr11	75115222	75115222	C	T	Missense_Mutation	p.T186I	1
RPS3	LIHC	chr11	75115172	75115172	G	A	Silent	p.V169V	1
RPS3	BLCA	chr11	75113378	75113379	-	CCTTGCTT	Frame_Shift_Ins	p.-98fs	1
RPS3	OV	chr11	74789474	74789474	G	A	Missense_Mutation	p.R40Q	1
RPS3	KIRP	chr11	75115876	75115876	G	T	Silent	p.P249P	1
RPS3	STAD	chr11	75115222	75115222	C	T	Missense_Mutation	p.T170I	1
RPS3	LIHC	chr11	75115172	75115172	G	A	Silent	p.V153V	1
RPS3	CESC	chr11	75115883	75115883	A	G	Missense_Mutation		1
RPS3	LGG	chr11	75113439	75113439	C	G	Missense_Mutation	p.A100G	1
RPS3	STAD	chr11	75115769	75115769	A	G	Missense_Mutation	p.I198V	1
RPS3	LIHC	chr11	75115814	75115814	C	-	Frame_Shift_Del	p.P213fs	1
RPS3	CHOL	chr11	75113481	75113481	C	T	Missense_Mutation		1
RPS3	READ	chr11	75115084	75115084	G	A	Missense_Mutation	p.R124Q	1
RPS3	LIHC	chr11	75115101	75115101	G	-	Frame_Shift_Del	p.G130fs	1
RPS3	CHOL	chr11	75113481	75113481	C	T	Missense_Mutation	p.A114V	1
RPS3	SARC	chr11	75110546	75110546	C	T	Missense_Mutation		1
RPS3	LGG	chr11	75115230	75115230	C	T	Missense_Mutation		1
RPS3	THYM	chr11	75113409	75113409	A	G	Missense_Mutation	p.K106R	1
RPS3	LUAD	chr11	75115888	75115888	C	T	Silent	p.P237P	1
RPS3	COAD	chr11	75113468	75113468	C	A	Missense_Mutation	p.L110I	1
RPS3	LGG	chr11	75113439	75113439	C	G	Missense_Mutation		1
RPS3	LUAD	chr11	75111773	75111773	T	A	Missense_Mutation	p.N22K	1
RPS3	HNSC	chr11	75115170	75115170	G	C	Missense_Mutation		1
RPS3	SKCM	chr11	75115202	75115202	T	C	Silent	p.P179P	1
RPS3	LIHC	chr11	75112773	75112773	T	A	Missense_Mutation		1
RPS3	LUAD	chr11	75115247	75115247	A	G	Silent	p.R178R	1
RPS3	SKCM	chr11	75115202	75115202	T	C	Silent	p.P163P	1
RPS3	LUAD	chr11	75115773	75115773	G	C	Missense_Mutation	p.G199A	1
RPS3	HNSC	chr11	75115170	75115170	G	C	Missense_Mutation	p.V153L	1
RPS3	SKCM	chr11	75113481	75113481	C	A	Missense_Mutation	p.A114D	1
RPS3	ACC	chr11	75115215	75115215	G	A	Missense_Mutation	p.V168I	1
RPS3	LUAD	chr11	75115252	75115252	G	A	Splice_Site		1
RPS3	HNSC	chr11	75111786	75111786	C	T	Missense_Mutation	p.R27W	1
RPS3	SKCM	chr11	75115750	75115750	C	T	Silent	p.P191P	1
RPS3	BLCA	chr11	75113378	75113379	-	-	Frame_Shift_Ins		1
RPS3	STAD	chr11	75115769	75115769	A	G	Missense_Mutation	p.I214V	1

Copy number variation (CNV) of RPS3
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
99494	N/A	AK172736	ANK3	chr10	62267257	-	RPS3	chr11	75115767	+
99494	N/A	AA533480	ARL15	chr5	53482834	+	RPS3	chr11	75116733	-
99494	STAD	TCGA-CD-A4MH-01A	BCL2L2	chr14	23777078	+	RPS3	chr11	75115837	+
99494	N/A	AA420813	CAGE1	chr6	7339413	+	RPS3	chr11	75115254	-
99494	N/A	AA564507	CAGE1	chr6	7339427	-	RPS3	chr11	75111736	+
99494	N/A	AA744407	CAGE1	chr6	7339415	+	RPS3	chr11	75116731	-
99494	N/A	BI491159	CAGE1	chr6	7339393	+	RPS3	chr11	75116729	-
99494	N/A	AX381668	DIP2A	chr21	47887711	+	RPS3	chr11	75116733	-
99494	N/A	AI658935	FAM168A	chr11	73185259	+	RPS3	chr11	75133349	-
99494	N/A	AA523799	FAM19A2	chr12	62415561	+	RPS3	chr11	75116731	-
99494	BRCA	TCGA-AQ-A04L-01B	NFIC	chr19	3463200	+	RPS3	chr11	75132771	+
99494	N/A	BI493957	NLK	chr17	26404134	+	RPS3	chr11	75116730	-
99494	N/A	BE388611	PKM	chr15	72501125	-	RPS3	chr11	75110594	+
99494	STAD	TCGA-EQ-A4SO-01A	PSMC3	chr11	47445980	-	RPS3	chr11	75115098	+
77917	N/A	BM014375	RPS3	chr11	75116736	+	ACCSL	chr11	44076023	-
102528	N/A	DA636472	RPS3	chr11	75115609	+	ARMC5	chr16	31471296	+
88811	N/A	BM016432	RPS3	chr11	75116733	+	B4GALT5	chr20	48324470	-
89070	N/A	BP262829	RPS3	chr11	75113427	+	C7orf31	chr7	25219874	-
86820	N/A	AA316665	RPS3	chr11	75113491	+	CAGE1	chr6	7339792	-
86820	N/A	BI857460	RPS3	chr11	75116727	+	CAGE1	chr6	7339810	-
86820	N/A	BI858770	RPS3	chr11	75115913	+	CAGE1	chr6	7339784	-
90269	N/A	BM844689	RPS3	chr11	75112774	+	CLDN4	chr7	73245834	+
97992	N/A	AA523366	RPS3	chr11	75116733	+	HIC2	chr22	21786966	+
96638	N/A	BI497276	RPS3	chr11	75116733	+	HLCS	chr21	38283711	+
92598	N/A	BP428906	RPS3	chr11	75116731	+	KDM2B	chr12	121944900	+
86641	ESCA	TCGA-ZR-A9CJ	RPS3	chr11	75111868	+	NETO2	chr16	47117712	-
99494	N/A	AA730765	RPS3	chr11	75115105	+	RPS3	chr11	75115890	-
99494	N/A	BG272850	RPS3	chr11	75115837	-	RPS3	chr11	75115732	+
99494	N/A	DL056688	RPS3	chr11	75115895	+	RPS3	chr11	75116689	-
92534	BRCA	TCGA-A8-A0A9-01A	RPS3	chr11	75115911	+	SLC6A15	chr12	85282559	+
92534	BRCA	TCGA-A8-A0A9-01A	RPS3	chr11	75115911	+	SLC6A15	chr12	85282793	+
96038	STAD	TCGA-D7-8573	RPS3	chr11	75110621	+	TBL1XR1	chr3	176816329	-
94639	BRCA	TCGA-A2-A3KC	RPS3	chr11	75113490	+	TSKU	chr11	76506652	+
94639	BRCA	TCGA-A2-A3KC-01A	RPS3	chr11	75113490	+	TSKU	chr11	76506653	+
95983	N/A	EC557161	RPS3	chr11	75115064	-	TSTD3	chr6	100023985	-
89965	STAD	TCGA-CG-4477	RPS3	chr11	75112777	+	UVRAG	chr11	75599872	+
102316	READ	TCGA-AG-3582	RPS3	chr11	75115227	+	ZNF536	chr19	31039220	+
99494	N/A	BG028694	SET	chr9	131457000	+	RPS3	chr11	75115861	+
99494	UCEC	TCGA-A5-A2K5	TRIM2	chr4	154125712	+	RPS3	chr11	75115715	+
99494	ESCA	TCGA-R6-A6Y0	UVRAG	chr11	75572825	+	RPS3	chr11	75111737	+
99494	N/A	BM823567	VSIG1	chrX	107322131	+	RPS3	chr11	75110563	+
99503	N/A	EC541268	WWOX	chr16	78859256	+	RPS3	chr11	75111736	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
UCEC	RPS3	0.594515386114053	-0.520008682422445	0.0224926112581877	0.0201267862555209	0.0217367362138644	188
LAML	RPS3	0.730503545028517	-0.314021194923601	0.0426881758041957	0.0471051084276976	0.0426432997615363	160
LGG	RPS3	0.546339855869166	-0.604514050229972	3.85144324180371e-05	3.78090300934012e-05	4.11368175506763e-05	525

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPS3	0.00748870438991886	0.21
MESO	RPS3	0.0139065647589991	0.38

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPS3	0.00615088072567869	0.2
LGG	RPS3	0.0330055528915568	0.96
BRCA	RPS3	0.00138446978168656	0.046
PAAD	RPS3	0.0297097635135152	0.89
SARC	RPS3	0.0224664118282249	0.7

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0025202	melanoma	1	CTD_human