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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS5 (NCBI Gene ID:6193)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS5
	Gene ID: 6193
	Gene Symbol	RPS5
	Gene ID	6193
	Gene Name	ribosomal protein S5
	Synonyms	S5
	Cytomap	19q13.43
	Type of Gene	protein-coding
	Description	40S ribosomal protein S5small ribosomal subunit protein uS7
	Modification date	20200313
	UniProtAcc	P46782

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS5	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS5[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS5	The Î²-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo	26134896

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000196551	58904342	58904552	In-frame
ENST00000596046	58904342	58904552	In-frame
ENST00000601521	58904342	58904552	In-frame
ENST00000196551	58904725	58904854	In-frame
ENST00000596046	58904725	58904854	In-frame
ENST00000601521	58904725	58904854	In-frame
ENST00000196551	58905863	58905962	In-frame
ENST00000596046	58905863	58905962	In-frame
ENST00000601521	58905863	58905962	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000196551	58904342	58904552	757	181	390	204	36	106
ENST00000601521	58904342	58904552	1220	641	850	204	36	106
ENST00000596046	58904342	58904552	1537	958	1167	204	36	106
ENST00000196551	58904725	58904854	757	391	519	204	106	149
ENST00000601521	58904725	58904854	1220	851	979	204	106	149
ENST00000596046	58904725	58904854	1537	1168	1296	204	106	149
ENST00000196551	58905863	58905962	757	520	618	204	149	182
ENST00000601521	58905863	58905962	1220	980	1078	204	149	182
ENST00000596046	58905863	58905962	1537	1297	1395	204	149	182

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P46782	106	149	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
P46782	36	106	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
P46782	149	182	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
P46782	106	149	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
P46782	36	106	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
P46782	149	182	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
P46782	106	149	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
P46782	36	106	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
P46782	149	182	1	204	Chain	ID=PRO_0000370369;Note=40S ribosomal protein S5
P46782	106	149	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
P46782	36	106	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
P46782	149	182	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
P46782	106	149	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
P46782	36	106	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
P46782	149	182	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
P46782	106	149	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
P46782	36	106	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
P46782	149	182	2	204	Chain	ID=PRO_0000124526;Note=40S ribosomal protein S5%2C N-terminally processed
P46782	36	106	47	47	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19608861;Dbxref=PMID:19608861
P46782	36	106	47	47	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19608861;Dbxref=PMID:19608861
P46782	36	106	47	47	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19608861;Dbxref=PMID:19608861
P46782	106	149	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
P46782	106	149	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
P46782	106	149	142	142	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
P46782	36	106	47	47	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
P46782	36	106	47	47	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
P46782	36	106	47	47	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
P46782	36	106	59	60	Sequence conflict	Note=KR->NA;Ontology_term=ECO:0000305;evidence=ECO:0000305
P46782	36	106	59	60	Sequence conflict	Note=KR->NA;Ontology_term=ECO:0000305;evidence=ECO:0000305
P46782	36	106	59	60	Sequence conflict	Note=KR->NA;Ontology_term=ECO:0000305;evidence=ECO:0000305

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BRCA	RPS5	1.85428655007552	0.00025235746216315
PRAD	RPS5	1.17578127105964	0.00341288625679289
COAD	RPS5	2.00837988822908	0.00355097651481629
LUAD	RPS5	-1.37520271628786	0.0182052890234661
KIRP	RPS5	-1.83720109968731	2.84211710095406e-05
KIRC	RPS5	-2.18493604007757	6.35837741288648e-10

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
MESO	RPS5	0.064164958	0.021232494
KIRC	RPS5	-0.054323715	0.030131338

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS5 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	Epifactor	RPS5	TRIM28	0.826751999	6.32E-21
ACC	IUPHAR	RPS5	TRIM28	0.826751999	6.32E-21
ACC	Kinase	RPS5	TRIM28	0.826751999	6.32E-21
ACC	TF	RPS5	ZNF581	0.823841824	1.13E-20
ACC	TSG	RPS5	GLTSCR2	0.817174957	4.14E-20
CESC	Cell metabolism gene	RPS5	SNRPD2	0.813830391	4.06E-74
CESC	TF	RPS5	ZNF581	0.835753043	1.18E-81
CHOL	Cell metabolism gene	RPS5	SNRPD2	0.841619855	4.46E-13
CHOL	Epifactor	RPS5	FBL	0.831523378	1.51E-12
CHOL	TF	RPS5	ZNF581	0.845779673	2.63E-13
CHOL	TSG	RPS5	GNB2L1	0.8177511	7.07E-12
CHOL	TSG	RPS5	GLTSCR2	0.864442004	2.00E-14
DLBC	Cell metabolism gene	RPS5	ATP5G1	0.803566615	6.21E-12
DLBC	Cell metabolism gene	RPS5	EXOSC5	0.804179029	5.82E-12
DLBC	Cell metabolism gene	RPS5	MIF	0.806932178	4.34E-12
DLBC	Cell metabolism gene	RPS5	TOMM22	0.810064847	3.09E-12
DLBC	Cell metabolism gene	RPS5	PPP2R1A	0.820108544	9.94E-13
DLBC	Cell metabolism gene	RPS5	SNRPB	0.820571287	9.42E-13
DLBC	Cell metabolism gene	RPS5	TIMM50	0.825780114	5.08E-13
DLBC	Cell metabolism gene	RPS5	GEMIN7	0.834451452	1.73E-13
DLBC	Cell metabolism gene	RPS5	TIMM9	0.83604345	1.41E-13
DLBC	Cell metabolism gene	RPS5	TIMM13	0.850598641	1.97E-14
DLBC	Cell metabolism gene	RPS5	NME2	0.854181138	1.17E-14
DLBC	Cell metabolism gene	RPS5	SNRPD2	0.885724616	6.13E-17
DLBC	CGC	RPS5	PPP2R1A	0.820108544	9.94E-13
DLBC	CGC	RPS5	NTHL1	0.822517859	7.50E-13
DLBC	Epifactor	RPS5	EXOSC5	0.804179029	5.82E-12
DLBC	Epifactor	RPS5	PRPF31	0.841988788	6.47E-14
DLBC	Epifactor	RPS5	RUVBL2	0.877201543	2.91E-16
DLBC	Epifactor	RPS5	FBL	0.908982991	4.23E-19
DLBC	IUPHAR	RPS5	SLC25A3	0.835272069	1.56E-13
DLBC	TF	RPS5	ZNF581	0.84080433	7.58E-14
DLBC	TF	RPS5	NME2	0.854181138	1.17E-14
DLBC	TSG	RPS5	GLTSCR2	0.865578299	2.05E-15
DLBC	TSG	RPS5	GNB2L1	0.87120537	8.16E-16
GBM	Cell metabolism gene	RPS5	SSR2	0.801668189	7.79E-40
GBM	Cell metabolism gene	RPS5	ZNRD1	0.802560228	5.53E-40
GBM	Cell metabolism gene	RPS5	AHCY	0.80334499	4.09E-40
GBM	Cell metabolism gene	RPS5	PSMD8	0.806717666	1.10E-40
GBM	Cell metabolism gene	RPS5	LSM2	0.811207445	1.83E-41
GBM	Cell metabolism gene	RPS5	GEMIN7	0.813737212	6.51E-42
GBM	Cell metabolism gene	RPS5	SNRPD2	0.886027895	1.22E-58
GBM	Epifactor	RPS5	PRMT1	0.823646594	9.81E-44
GBM	IUPHAR	RPS5	AHCY	0.80334499	4.09E-40
GBM	IUPHAR	RPS5	PRMT1	0.823646594	9.81E-44
GBM	TF	RPS5	ZNF581	0.807299455	8.72E-41
GBM	TF	RPS5	ZNF627	0.812117467	1.26E-41
KICH	Cell metabolism gene	RPS5	SNRPD2	0.843379958	9.74E-26
KIRP	TF	RPS5	ZNF581	0.841492842	7.77E-88
LGG	Epifactor	RPS5	FBL	0.843222136	1.91E-144
LGG	TF	RPS5	ZNF581	0.807173185	5.82E-123
LIHC	Epifactor	RPS5	FBL	0.833388689	1.79E-110
LIHC	TF	RPS5	ZNF581	0.854164816	1.25E-121
MESO	TF	RPS5	ZNF581	0.827477275	5.14E-23
PCPG	Epifactor	RPS5	FBL	0.83399637	1.18E-49
PCPG	TSG	RPS5	GLTSCR2	0.803262121	1.71E-43
PRAD	Epifactor	RPS5	FBL	0.83663369	2.28E-145
PRAD	TF	RPS5	ZNF581	0.836983245	1.34E-145
PRAD	TSG	RPS5	GNB2L1	0.880837435	4.19E-180
SKCM	TF	RPS5	ZNF581	0.82696595	4.11E-120
TGCT	Epifactor	RPS5	FBL	0.824885368	5.50E-40
THYM	Cell metabolism gene	RPS5	UCKL1	0.800945422	1.68E-28
THYM	Cell metabolism gene	RPS5	MIF	0.803214836	9.06E-29
THYM	Cell metabolism gene	RPS5	DPM3	0.803253715	8.96E-29
THYM	Cell metabolism gene	RPS5	PSMD13	0.804688616	6.05E-29
THYM	Cell metabolism gene	RPS5	PSME1	0.807342337	2.90E-29
THYM	Cell metabolism gene	RPS5	ALG3	0.807385774	2.86E-29
THYM	Cell metabolism gene	RPS5	MTX1	0.808465661	2.12E-29
THYM	Cell metabolism gene	RPS5	HMOX2	0.808738692	1.96E-29
THYM	Cell metabolism gene	RPS5	TOMM40	0.810023014	1.36E-29
THYM	Cell metabolism gene	RPS5	NOP56	0.812846215	6.07E-30
THYM	Cell metabolism gene	RPS5	GCDH	0.816724817	1.96E-30
THYM	Cell metabolism gene	RPS5	FPGS	0.81720408	1.70E-30
THYM	Cell metabolism gene	RPS5	IDH3B	0.819390864	8.83E-31
THYM	Cell metabolism gene	RPS5	PSMD4	0.819900688	7.58E-31
THYM	Cell metabolism gene	RPS5	LSM2	0.82054827	6.23E-31
THYM	Cell metabolism gene	RPS5	POLE4	0.820918678	5.57E-31
THYM	Cell metabolism gene	RPS5	POLR2E	0.822225562	3.74E-31
THYM	Cell metabolism gene	RPS5	TIMM10	0.822450155	3.49E-31
THYM	Cell metabolism gene	RPS5	SRM	0.823120059	2.84E-31
THYM	Cell metabolism gene	RPS5	OAZ1	0.824676225	1.76E-31
THYM	Cell metabolism gene	RPS5	ITPA	0.825099268	1.54E-31
THYM	Cell metabolism gene	RPS5	SNRPE	0.825268021	1.46E-31
THYM	Cell metabolism gene	RPS5	DTYMK	0.825775184	1.25E-31
THYM	Cell metabolism gene	RPS5	PFDN5	0.825897124	1.20E-31
THYM	Cell metabolism gene	RPS5	EBP	0.829080468	4.39E-32
THYM	Cell metabolism gene	RPS5	PTGES2	0.829225755	4.19E-32
THYM	Cell metabolism gene	RPS5	NANS	0.832223696	1.59E-32
THYM	Cell metabolism gene	RPS5	PSMD8	0.833975528	8.97E-33
THYM	Cell metabolism gene	RPS5	POLR2F	0.835903423	4.73E-33
THYM	Cell metabolism gene	RPS5	GEMIN7	0.836515445	3.85E-33
THYM	Cell metabolism gene	RPS5	TALDO1	0.837746292	2.54E-33
THYM	Cell metabolism gene	RPS5	APRT	0.838942158	1.70E-33
THYM	Cell metabolism gene	RPS5	HMBS	0.839558337	1.37E-33
THYM	Cell metabolism gene	RPS5	MVD	0.841823688	6.28E-34
THYM	Cell metabolism gene	RPS5	POLR2H	0.84210826	5.69E-34
THYM	Cell metabolism gene	RPS5	GUK1	0.842265383	5.39E-34
THYM	Cell metabolism gene	RPS5	TIMM8B	0.842828685	4.42E-34
THYM	Cell metabolism gene	RPS5	POLR2I	0.843282378	3.77E-34
THYM	Cell metabolism gene	RPS5	GMPPA	0.84588821	1.50E-34
THYM	Cell metabolism gene	RPS5	DPM2	0.849186426	4.53E-35
THYM	Cell metabolism gene	RPS5	PSMB3	0.850008004	3.35E-35
THYM	Cell metabolism gene	RPS5	PSMC3	0.851799917	1.72E-35
THYM	Cell metabolism gene	RPS5	FAU	0.85804305	1.58E-36
THYM	Cell metabolism gene	RPS5	EXOSC5	0.861203904	4.52E-37
THYM	Cell metabolism gene	RPS5	TOMM22	0.862802797	2.37E-37
THYM	Cell metabolism gene	RPS5	PMPCA	0.863687121	1.65E-37
THYM	Cell metabolism gene	RPS5	IMPDH2	0.866021939	6.31E-38
THYM	Cell metabolism gene	RPS5	ACOT8	0.866420357	5.34E-38
THYM	Cell metabolism gene	RPS5	PSMB7	0.869233585	1.62E-38
THYM	Cell metabolism gene	RPS5	TIMM50	0.877941549	3.40E-40
THYM	Cell metabolism gene	RPS5	SSR2	0.882708017	3.61E-41
THYM	Cell metabolism gene	RPS5	EXOSC4	0.883593132	2.36E-41
THYM	Cell metabolism gene	RPS5	PGLS	0.886861823	4.72E-42
THYM	Cell metabolism gene	RPS5	POLD2	0.888139611	2.48E-42
THYM	Cell metabolism gene	RPS5	SLC27A5	0.892423216	2.72E-43
THYM	Cell metabolism gene	RPS5	SNRPD2	0.90720109	6.02E-47
THYM	Cell metabolism gene	RPS5	TIMM13	0.923883068	6.84E-52
THYM	CGC	RPS5	ASPSCR1	0.809403524	1.62E-29
THYM	CGC	RPS5	RBM10	0.845150404	1.95E-34
THYM	CGC	RPS5	SDHAF2	0.850765037	2.53E-35
THYM	CGC	RPS5	TFPT	0.866501738	5.16E-38
THYM	Epifactor	RPS5	PPP4C	0.812904541	5.97E-30
THYM	Epifactor	RPS5	PAF1	0.813596803	4.89E-30
THYM	Epifactor	RPS5	ZNHIT1	0.823086383	2.87E-31
THYM	Epifactor	RPS5	RUVBL2	0.830049693	3.22E-32
THYM	Epifactor	RPS5	C17orf49	0.832207233	1.60E-32
THYM	Epifactor	RPS5	TAF10	0.835770679	4.94E-33
THYM	Epifactor	RPS5	SIRT6	0.840369595	1.04E-33
THYM	Epifactor	RPS5	LAS1L	0.850857643	2.45E-35
THYM	Epifactor	RPS5	RRP8	0.852663726	1.25E-35
THYM	Epifactor	RPS5	MBD3	0.85384766	7.97E-36
THYM	Epifactor	RPS5	PRMT1	0.858966186	1.10E-36
THYM	Epifactor	RPS5	NOC2L	0.859746034	8.09E-37
THYM	Epifactor	RPS5	EXOSC5	0.861203904	4.52E-37
THYM	Epifactor	RPS5	TFPT	0.866501738	5.16E-38
THYM	Epifactor	RPS5	BRMS1	0.878964665	2.12E-40
THYM	Epifactor	RPS5	EXOSC4	0.883593132	2.36E-41
THYM	Epifactor	RPS5	PRPF31	0.892958431	2.05E-43
THYM	Epifactor	RPS5	FBL	0.943644214	1.82E-59
THYM	IUPHAR	RPS5	HMOX2	0.808738692	1.96E-29
THYM	IUPHAR	RPS5	PTGES2	0.829225755	4.19E-32
THYM	IUPHAR	RPS5	SIRT6	0.840369595	1.04E-33
THYM	IUPHAR	RPS5	MVD	0.841823688	6.28E-34
THYM	IUPHAR	RPS5	EGLN2	0.850891664	2.42E-35
THYM	IUPHAR	RPS5	PRMT1	0.858966186	1.10E-36
THYM	IUPHAR	RPS5	IMPDH2	0.866021939	6.31E-38
THYM	IUPHAR	RPS5	SLC27A5	0.892423216	2.72E-43
THYM	Kinase	RPS5	ADCK4	0.836580219	3.77E-33
THYM	TF	RPS5	USF1	0.801854191	1.31E-28
THYM	TF	RPS5	ZNF688	0.803197221	9.10E-29
THYM	TF	RPS5	ZNF428	0.807689598	2.63E-29
THYM	TF	RPS5	ZNF524	0.808247308	2.25E-29
THYM	TF	RPS5	ZNF787	0.833075956	1.21E-32
THYM	TF	RPS5	MBD3	0.85384766	7.97E-36
THYM	TF	RPS5	REXO4	0.860275653	6.55E-37
THYM	TF	RPS5	ZNF581	0.909584503	1.36E-47
THYM	TSG	RPS5	NPRL2	0.804824958	5.83E-29
THYM	TSG	RPS5	STUB1	0.827207303	7.96E-32
THYM	TSG	RPS5	PHB	0.828964026	4.56E-32
THYM	TSG	RPS5	GADD45GIP1	0.838598102	1.91E-33
THYM	TSG	RPS5	SIRT6	0.840369595	1.04E-33
THYM	TSG	RPS5	GLTSCR2	0.858365378	1.39E-36
THYM	TSG	RPS5	GNB2L1	0.867447642	3.47E-38
THYM	TSG	RPS5	BRMS1	0.878964665	2.12E-40
THYM	TSG	RPS5	TSSC4	0.893995845	1.18E-43
UCS	Cell metabolism gene	RPS5	UCKL1	0.800945422	1.68E-28
UCS	Cell metabolism gene	RPS5	MIF	0.803214836	9.06E-29
UCS	Cell metabolism gene	RPS5	DPM3	0.803253715	8.96E-29
UCS	Cell metabolism gene	RPS5	PSMD13	0.804688616	6.05E-29
UCS	Cell metabolism gene	RPS5	PSME1	0.807342337	2.90E-29
UCS	Cell metabolism gene	RPS5	ALG3	0.807385774	2.86E-29
UCS	Cell metabolism gene	RPS5	MTX1	0.808465661	2.12E-29
UCS	Cell metabolism gene	RPS5	HMOX2	0.808738692	1.96E-29
UCS	Cell metabolism gene	RPS5	TOMM40	0.810023014	1.36E-29
UCS	Cell metabolism gene	RPS5	NOP56	0.812846215	6.07E-30
UCS	Cell metabolism gene	RPS5	GCDH	0.816724817	1.96E-30
UCS	Cell metabolism gene	RPS5	FPGS	0.81720408	1.70E-30
UCS	Cell metabolism gene	RPS5	IDH3B	0.819390864	8.83E-31
UCS	Cell metabolism gene	RPS5	PSMD4	0.819900688	7.58E-31
UCS	Cell metabolism gene	RPS5	LSM2	0.82054827	6.23E-31
UCS	Cell metabolism gene	RPS5	POLE4	0.820918678	5.57E-31
UCS	Cell metabolism gene	RPS5	POLR2E	0.822225562	3.74E-31
UCS	Cell metabolism gene	RPS5	TIMM10	0.822450155	3.49E-31
UCS	Cell metabolism gene	RPS5	SRM	0.823120059	2.84E-31
UCS	Cell metabolism gene	RPS5	OAZ1	0.824676225	1.76E-31
UCS	Cell metabolism gene	RPS5	ITPA	0.825099268	1.54E-31
UCS	Cell metabolism gene	RPS5	SNRPE	0.825268021	1.46E-31
UCS	Cell metabolism gene	RPS5	DTYMK	0.825775184	1.25E-31
UCS	Cell metabolism gene	RPS5	PFDN5	0.825897124	1.20E-31
UCS	Cell metabolism gene	RPS5	EBP	0.829080468	4.39E-32
UCS	Cell metabolism gene	RPS5	PTGES2	0.829225755	4.19E-32
UCS	Cell metabolism gene	RPS5	NANS	0.832223696	1.59E-32
UCS	Cell metabolism gene	RPS5	PSMD8	0.833975528	8.97E-33
UCS	Cell metabolism gene	RPS5	POLR2F	0.835903423	4.73E-33
UCS	Cell metabolism gene	RPS5	GEMIN7	0.836515445	3.85E-33
UCS	Cell metabolism gene	RPS5	TALDO1	0.837746292	2.54E-33
UCS	Cell metabolism gene	RPS5	APRT	0.838942158	1.70E-33
UCS	Cell metabolism gene	RPS5	HMBS	0.839558337	1.37E-33
UCS	Cell metabolism gene	RPS5	MVD	0.841823688	6.28E-34
UCS	Cell metabolism gene	RPS5	POLR2H	0.84210826	5.69E-34
UCS	Cell metabolism gene	RPS5	GUK1	0.842265383	5.39E-34
UCS	Cell metabolism gene	RPS5	TIMM8B	0.842828685	4.42E-34
UCS	Cell metabolism gene	RPS5	POLR2I	0.843282378	3.77E-34
UCS	Cell metabolism gene	RPS5	GMPPA	0.84588821	1.50E-34
UCS	Cell metabolism gene	RPS5	DPM2	0.849186426	4.53E-35
UCS	Cell metabolism gene	RPS5	PSMB3	0.850008004	3.35E-35
UCS	Cell metabolism gene	RPS5	PSMC3	0.851799917	1.72E-35
UCS	Cell metabolism gene	RPS5	FAU	0.85804305	1.58E-36
UCS	Cell metabolism gene	RPS5	EXOSC5	0.861203904	4.52E-37
UCS	Cell metabolism gene	RPS5	TOMM22	0.862802797	2.37E-37
UCS	Cell metabolism gene	RPS5	PMPCA	0.863687121	1.65E-37
UCS	Cell metabolism gene	RPS5	IMPDH2	0.866021939	6.31E-38
UCS	Cell metabolism gene	RPS5	ACOT8	0.866420357	5.34E-38
UCS	Cell metabolism gene	RPS5	PSMB7	0.869233585	1.62E-38
UCS	Cell metabolism gene	RPS5	TIMM50	0.877941549	3.40E-40
UCS	Cell metabolism gene	RPS5	SSR2	0.882708017	3.61E-41
UCS	Cell metabolism gene	RPS5	EXOSC4	0.883593132	2.36E-41
UCS	Cell metabolism gene	RPS5	PGLS	0.886861823	4.72E-42
UCS	Cell metabolism gene	RPS5	POLD2	0.888139611	2.48E-42
UCS	Cell metabolism gene	RPS5	SLC27A5	0.892423216	2.72E-43
UCS	Cell metabolism gene	RPS5	SNRPD2	0.90720109	6.02E-47
UCS	Cell metabolism gene	RPS5	TIMM13	0.923883068	6.84E-52
UCS	CGC	RPS5	ASPSCR1	0.809403524	1.62E-29
UCS	CGC	RPS5	RBM10	0.845150404	1.95E-34
UCS	CGC	RPS5	SDHAF2	0.850765037	2.53E-35
UCS	CGC	RPS5	TFPT	0.866501738	5.16E-38
UCS	Epifactor	RPS5	PPP4C	0.812904541	5.97E-30
UCS	Epifactor	RPS5	PAF1	0.813596803	4.89E-30
UCS	Epifactor	RPS5	ZNHIT1	0.823086383	2.87E-31
UCS	Epifactor	RPS5	RUVBL2	0.830049693	3.22E-32
UCS	Epifactor	RPS5	C17orf49	0.832207233	1.60E-32
UCS	Epifactor	RPS5	TAF10	0.835770679	4.94E-33
UCS	Epifactor	RPS5	SIRT6	0.840369595	1.04E-33
UCS	Epifactor	RPS5	LAS1L	0.850857643	2.45E-35
UCS	Epifactor	RPS5	RRP8	0.852663726	1.25E-35
UCS	Epifactor	RPS5	MBD3	0.85384766	7.97E-36
UCS	Epifactor	RPS5	PRMT1	0.858966186	1.10E-36
UCS	Epifactor	RPS5	NOC2L	0.859746034	8.09E-37
UCS	Epifactor	RPS5	EXOSC5	0.861203904	4.52E-37
UCS	Epifactor	RPS5	TFPT	0.866501738	5.16E-38
UCS	Epifactor	RPS5	BRMS1	0.878964665	2.12E-40
UCS	Epifactor	RPS5	EXOSC4	0.883593132	2.36E-41
UCS	Epifactor	RPS5	PRPF31	0.892958431	2.05E-43
UCS	Epifactor	RPS5	FBL	0.943644214	1.82E-59
UCS	IUPHAR	RPS5	HMOX2	0.808738692	1.96E-29
UCS	IUPHAR	RPS5	PTGES2	0.829225755	4.19E-32
UCS	IUPHAR	RPS5	SIRT6	0.840369595	1.04E-33
UCS	IUPHAR	RPS5	MVD	0.841823688	6.28E-34
UCS	IUPHAR	RPS5	EGLN2	0.850891664	2.42E-35
UCS	IUPHAR	RPS5	PRMT1	0.858966186	1.10E-36
UCS	IUPHAR	RPS5	IMPDH2	0.866021939	6.31E-38
UCS	IUPHAR	RPS5	SLC27A5	0.892423216	2.72E-43
UCS	Kinase	RPS5	ADCK4	0.836580219	3.77E-33
UCS	TF	RPS5	USF1	0.801854191	1.31E-28
UCS	TF	RPS5	ZNF688	0.803197221	9.10E-29
UCS	TF	RPS5	ZNF428	0.807689598	2.63E-29
UCS	TF	RPS5	ZNF524	0.808247308	2.25E-29
UCS	TF	RPS5	ZNF787	0.833075956	1.21E-32
UCS	TF	RPS5	MBD3	0.85384766	7.97E-36
UCS	TF	RPS5	REXO4	0.860275653	6.55E-37
UCS	TF	RPS5	ZNF581	0.909584503	1.36E-47
UCS	TSG	RPS5	NPRL2	0.804824958	5.83E-29
UCS	TSG	RPS5	STUB1	0.827207303	7.96E-32
UCS	TSG	RPS5	PHB	0.828964026	4.56E-32
UCS	TSG	RPS5	GADD45GIP1	0.838598102	1.91E-33
UCS	TSG	RPS5	SIRT6	0.840369595	1.04E-33
UCS	TSG	RPS5	GLTSCR2	0.858365378	1.39E-36
UCS	TSG	RPS5	GNB2L1	0.867447642	3.47E-38
UCS	TSG	RPS5	BRMS1	0.878964665	2.12E-40
UCS	TSG	RPS5	TSSC4	0.893995845	1.18E-43
UVM	Cell metabolism gene	RPS5	SLC27A5	0.803577158	2.95E-19
UVM	Cell metabolism gene	RPS5	SLC25A6	0.828031547	2.72E-21
UVM	Cell metabolism gene	RPS5	IMPDH2	0.841716904	1.41E-22
UVM	Cell metabolism gene	RPS5	SSR2	0.87303169	4.84E-26
UVM	Cell metabolism gene	RPS5	FAU	0.875005941	2.73E-26
UVM	CGC	RPS5	TRAF7	0.822794011	7.87E-21
UVM	Epifactor	RPS5	TRIM28	0.833312642	8.95E-22
UVM	Epifactor	RPS5	FBL	0.932002046	4.04E-36
UVM	IUPHAR	RPS5	SLC27A5	0.803577158	2.95E-19
UVM	IUPHAR	RPS5	SLC25A6	0.828031547	2.72E-21
UVM	IUPHAR	RPS5	TRIM28	0.833312642	8.95E-22
UVM	IUPHAR	RPS5	IMPDH2	0.841716904	1.41E-22
UVM	Kinase	RPS5	TRIM28	0.833312642	8.95E-22
UVM	TF	RPS5	REXO4	0.802710995	3.44E-19
UVM	TF	RPS5	ZNF581	0.88214779	3.17E-27
UVM	TSG	RPS5	GNB2L1	0.912069516	6.22E-32
UVM	TSG	RPS5	GLTSCR2	0.914318703	2.36E-32

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS5	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS5	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS5	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPS5	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS5	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS5	RPL8	-4.84588284974558	0.00110314154326131
LIHC	RPS5	FBL	-1.52440225286776	0.00135114801221843
ESCA	RPS5	FBL	-3.20818772056068	0.001953125
PRAD	RPS5	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS5	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS5	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS5	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS5	RPS16	-6.16322798156577	0.0115764821363307
STAD	RPS5	FBL	-3.09283533727097	0.0118026207201183
BLCA	RPS5	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS5	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS5	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS5	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS5	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPS5	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS5	RPS12	-4.91239327478244	1.85340619742495e-09
KIRC	RPS5	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS5	FBL	-1.48689317058746	4.1409317182671e-10
KIRC	RPS5	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS5	RPL8	-1.53003692350119	6.0301274061203e-05
LUAD	RPS5	FBL	-1.63102492950895	7.73559543739736e-08
KIRC	RPS5	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS5	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRP	RPS5	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS5	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS5	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS5

SRRM1, SRRM2, AGO4, RICTOR, VHL, RAD21, SIRT7, CUL3, CUL5, CDK2, CUL1, CAND1, PIK3R2, CRK, RPS4X, UBE2D3, RPL10A, RPL12, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL24, RPL30, RPL31, RPL5, RPL6, RPL7A, RPL9, RPS11, RPS13, RPS15A, RPS16, RPS19, RPS23, RPS24, RPS2, RPS3A, RPS3, RPS6, RPS8, RPSA, RPL4, RPS7, RPL11, RPL7, RPL23A, RPL14, RPS14, RPL37A, RPLP2, RPL23, RPS26, RPS12, RPLP1, RPLP0, RPL17, RPS21, RPS27A, EEF1A1, EEF2, NOP56, FBL, GNL3, DHX9, NCL, NHP2L1, TUFM, HNRNPM, HNRNPA1, EIF6, RPL10L, RPLP0P6, RBM14, SNRPA1, LOC255308, NOP2, ATP6V1B2, CA9, SMURF1, FN1, VCAM1, UBL4A, ITGA4, PAN2, NPM1, ADRB2, FBXO6, EIF3CL, GNB2L1, LARP1, NCAPD2, PNO1, RPS10, RPS20, RPS25, RPS27, RPS28, RPS29, DYNC1H1, DYNC1I2, DYNC1LI2, DYNLL1, EIF2A, EIF3L, PRUNE2, RPS18, RPS9, TSR1, WIBG, rev, RPA3, RPA2, RPA1, AURKA, FUS, MOV10, NXF1, CUL7, UBC, HIST1H1A, NOL12, RPS6KB2, CANX, CLGN, GFM2, HBS1L, HNRNPK, KRR1, MRPL11, MRPL22, MRPL24, MRPS10, MSH2, NAT10, NOL6, POLR1A, RPL13A, RPL22, RPL27, RPL27A, RPL35, RPL38, RPL8, RPS15, LOC101929876, MRPL3, POLR1B, POLR2B, POLR2E, POLR3A, RPL10, RPL13, RPL26, RPL3, RPL35A, RPL36, SEC63, SPDL1, RRP7A, SEC61A1, SLC25A1, UBA52, WDR36, NTRK1, gag, XPO1, HNRNPU, Rpl35, Srp72, Rrbp1, GAN, MCM2, NF2, Ksr1, RC3H1, CDC73, RRS1, ZCRB1, HIST1H1T, H2AFX, CYLD, FOXA1, HEY1, BRCA1, HDAC6, ACO2, WDR77, CDK9, ARNT, COPE, CTNNB1, HDAC4, TGFB1, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, CHD4, RIOK1, HEXIM1, MEPCE, LARP7, MDM2, SENP2, SNAI1, RECQL4, ZBTB38, GPC1, ZFP36L2, MYC, METTL14, EIF4B, RC3H2, ACTC1, PHB, RBX1, NR2C2, PPP1CC, CTCF, HIST1H4A, LUCAT1, SNRNP70, ITFG1, HMGB1, BIRC3, NFX1, WWP2, SQSTM1, PLEKHA4, MAGEA3, YAP1, TFCP2, FANCD2, PTEN, HCVgp1, ZC3H18, NEK4, DUX4, CIT, ANLN, AURKB, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, FASN, MKI67, LRRC59, INS, Rnf183, BRD4, RBM45, CIC, Apc2, FBP1, BKRF1, RIN3, SPOP, AR, PARK2, UFL1, DDRGK1, TRIM37, ATG7, FZR1, MYCBP2, WDR5, PAGE4, NUDCD2, PRR3, HIST1H2AM, FGF13, HIST1H1D, LIN28B, YBX2, DDX21, RPL23AP32, THAP3, H1FNT, ZNF668, FGF17, HIST1H1C, PURG, LLPH, H2AFB2, HIST1H1B, SRSF6, SRSF5, ABT1, SURF6, RPL26L1, LIN28A, UTP23, RSL1D1, ZNF346, FGFBP1, NEIL1, RPSAP58, HIST1H1E, BTF3, FBXW7, M, nsp6, UBE2N, RCHY1, CCNF, MAP1LC3B, N, SIRT6, PSMD9, KLF15, KLF16, KLF4, KLF5, KLF8,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene

Cancer type

Chromosome

Start

End

RefSeeq

MutSeq

Mutation type

AAchange

# samples

Copy number variation (CNV) of RPS5
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS5
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102445	N/A	BQ227834	ACTG1	chr17	79477287	+	RPS5	chr19	58898661	+
102445	N/A	CF128579	CD63	chr12	56119614	-	RPS5	chr19	58904396	+
102445	LUAD	TCGA-05-4398-01A	CLPTM1	chr19	45458724	+	RPS5	chr19	58904726	+
102445	N/A	BQ432456	CTDSP1	chr2	219264765	+	RPS5	chr19	58904350	+
102445	N/A	BM971373	DSE	chr6	116580306	+	RPS5	chr19	58906169	-
102445	N/A	BG231158	IFT46	chr11	118419101	+	RPS5	chr19	58906167	-
102445	N/A	BU175700	MRPS21	chr1	150280782	+	RPS5	chr19	58904724	+
102445	PAAD	TCGA-IB-7885	RPL23AP79	chr19	59086955	+	RPS5	chr19	58904343	+
100956	PRAD	TCGA-CH-5771-01A	RPS5	chr19	58906170	-	CALD1	chr7	134430218	+
97057	N/A	BG574864	RPS5	chr19	58906167	+	CCDC129	chr7	31693666	+
77972	N/A	BG575270	RPS5	chr19	58906169	+	CDH7	chr18	63533540	+
77972	N/A	BF337147	RPS5	chr19	58906168	+	CLMN	chr14	95746325	-
102507	CESC	TCGA-LP-A5U2-01A	RPS5	chr19	58906170	-	DDX21	chr10	70723858	+
94838	N/A	AA528326	RPS5	chr19	58904328	-	DSE	chr6	116579851	+
94838	N/A	AA877012	RPS5	chr19	58906171	+	DSE	chr6	116579677	-
94838	N/A	BF437270	RPS5	chr19	58905862	-	DSE	chr6	116579611	+
94838	N/A	BG031186	RPS5	chr19	58906171	+	DSE	chr6	116579684	-
94838	N/A	BM014279	RPS5	chr19	58906171	+	DSE	chr6	116579639	-
94838	N/A	CF123717	RPS5	chr19	58906165	+	DSE	chr6	116579684	-
78381	N/A	BF337460	RPS5	chr19	58906167	+	DTNBP1	chr6	15637088	-
103029	STAD	TCGA-BR-4292	RPS5	chr19	58905962	+	EEF2	chr19	3980707	-
102493	N/A	U50079	RPS5	chr19	58898660	-	HDAC1	chr1	32757757	+
97196	N/A	CF272432	RPS5	chr19	58906171	+	MFN1	chr3	179078333	+
103124	LAML	TCGA-AB-2874-03A	RPS5	chr19	58905918	+	MPO	chr17	56347363	-
77972	N/A	AA535498	RPS5	chr19	58906171	+	RAB41	chrX	69504089	-
102445	N/A	EC459447	RPS5	chr19	58904826	+	RPS5	chr19	58904438	+
84556	SARC	TCGA-MJ-A68H-01A	RPS5	chr19	58899612	+	SLC27A5	chr19	59012777	-
90439	N/A	BF339864	RPS5	chr19	58906167	+	STIM2	chr4	26873343	-
91991	N/A	BG575553	RPS5	chr19	58906169	+	TMEM246	chr9	104266500	-
102445	N/A	BG929094	SPIN3	chrX	57017834	-	RPS5	chr19	58905861	+
102445	N/A	AA533269	TAB2	chr6	149645982	+	RPS5	chr19	58906171	-
102445	BRCA	TCGA-B6-A40B	TM6SF2	chr19	19383929	-	RPS5	chr19	58905863	+
102445	PAAD	TCGA-3A-A9J0	ZNF584	chr19	58913029	+	RPS5	chr19	58899504	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPS5	0.00253769109112375	0.071
COAD	RPS5	0.00641786815096913	0.17

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPS5	0.0425286733559275	1
BRCA	RPS5	0.00286472908320581	0.095
PAAD	RPS5	0.0094276956613236	0.3

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source