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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS6 (NCBI Gene ID:6194)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS6
	Gene ID: 6194
	Gene Symbol	RPS6
	Gene ID	6194
	Gene Name	ribosomal protein S6
	Synonyms	S6
	Cytomap	9p22.1
	Type of Gene	protein-coding
	Description	40S ribosomal protein S6phosphoprotein NP33small ribosomal subunit protein eS6
	Modification date	20200313
	UniProtAcc	P62753

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS6	GO:0031929	TOR signaling	16428328
Hgene	RPS6	GO:0043065	positive regulation of apoptotic process	18362888

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS6	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS6[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS6	IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils	26276876

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000380394	19376491	19376649	Frame-shift
ENST00000380394	19378365	19378512	In-frame
ENST00000380394	19378705	19378916	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000380394	19378365	19378512	1404	409	555	249	116	165

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P62753	116	165	1	249	Chain	ID=PRO_0000137312;Note=40S ribosomal protein S6
P62753	116	165	148	148	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
P62753	116	165	144	144	Sequence conflict	Note=L->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P62753	116	165	155	156	Sequence conflict	Note=QY->EC;Ontology_term=ECO:0000305;evidence=ECO:0000305

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRC	RPS6	-3.4556058277803	0.0001224322154943
THCA	RPS6	1.46346143665389	0.00305071956645465
KIRP	RPS6	-1.15360907834159	0.0111397774890065
COAD	RPS6	1.03379589520851	0.011966735124588
BLCA	RPS6	-1.76940777579938	0.012359619140625

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
UCEC	RPS6	hsa-miR-532-5p	97	-0.347288006111535	0.0448060033675934

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
OV	RPS6	0.0619036	0.021929525
TGCT	RPS6	0.082758705	0.027618483
UCS	RPS6	0.055924765	0.048521943

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS6 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	RPS6	TIMM9	0.801280949	7.90E-12
DLBC	CGC	RPS6	NACA	0.842946966	5.68E-14
DLBC	TSG	RPS6	GNB2L1	0.89544563	8.83E-18
LAML	CGC	RPS6	NACA	0.822952329	7.52E-44
LGG	Cell metabolism gene	RPS6	FAU	0.809257162	4.47E-124
LGG	CGC	RPS6	NACA	0.834184169	1.41E-138
PCPG	CGC	RPS6	NACA	0.833239632	1.73E-49
PCPG	TSG	RPS6	GLTSCR2	0.813068158	2.46E-45
PCPG	TSG	RPS6	GNB2L1	0.852408086	5.50E-54
PRAD	Cell metabolism gene	RPS6	TIMM9	0.801931191	1.07E-124
PRAD	Cell metabolism gene	RPS6	FAU	0.806647398	2.94E-127
PRAD	CGC	RPS6	NACA	0.886389577	1.96E-185
PRAD	Epifactor	RPS6	FBL	0.805735312	9.31E-127
PRAD	TSG	RPS6	GAS5	0.844927894	4.90E-151
PRAD	TSG	RPS6	GNB2L1	0.887407748	1.93E-186
THCA	Cell metabolism gene	RPS6	FAU	0.836517666	4.77E-151
THCA	CGC	RPS6	NACA	0.821118807	6.11E-141
THCA	TSG	RPS6	GAS5	0.813318261	3.49E-136
THCA	TSG	RPS6	GNB2L1	0.825991319	4.97E-144
THYM	Cell metabolism gene	RPS6	PSMC3	0.801376789	1.49E-28
THYM	Cell metabolism gene	RPS6	TXN	0.802039572	1.25E-28
THYM	Cell metabolism gene	RPS6	PAFAH1B3	0.802059843	1.24E-28
THYM	Cell metabolism gene	RPS6	DGUOK	0.803892979	7.53E-29
THYM	Cell metabolism gene	RPS6	SNRPD1	0.806823897	3.35E-29
THYM	Cell metabolism gene	RPS6	LSM4	0.808075504	2.36E-29
THYM	Cell metabolism gene	RPS6	TOMM22	0.809640774	1.52E-29
THYM	Cell metabolism gene	RPS6	PSMD13	0.814795227	3.45E-30
THYM	Cell metabolism gene	RPS6	PSMB7	0.815734614	2.62E-30
THYM	Cell metabolism gene	RPS6	SEC61B	0.817449294	1.58E-30
THYM	Cell metabolism gene	RPS6	SNRPF	0.822619886	3.32E-31
THYM	Cell metabolism gene	RPS6	EXOSC1	0.826155734	1.11E-31
THYM	Cell metabolism gene	RPS6	LSM2	0.83120548	2.22E-32
THYM	Cell metabolism gene	RPS6	TIMM8B	0.834696342	7.07E-33
THYM	Cell metabolism gene	RPS6	SNRPD2	0.845824208	1.53E-34
THYM	Cell metabolism gene	RPS6	LSM5	0.851417916	1.99E-35
THYM	Cell metabolism gene	RPS6	FAU	0.85519536	4.77E-36
THYM	CGC	RPS6	NACA	0.805214395	5.23E-29
THYM	Epifactor	RPS6	PPM1G	0.804026565	7.26E-29
THYM	Epifactor	RPS6	FBL	0.806470192	3.70E-29
THYM	Epifactor	RPS6	RUVBL2	0.807017939	3.17E-29
THYM	Epifactor	RPS6	EXOSC1	0.826155734	1.11E-31
THYM	Epifactor	RPS6	RBX1	0.840904951	8.64E-34
THYM	Epifactor	RPS6	TAF10	0.848032709	6.91E-35
THYM	Epifactor	RPS6	SS18L2	0.8645381	1.17E-37
THYM	IUPHAR	RPS6	PPIA	0.821850083	4.20E-31
THYM	TF	RPS6	ZNF444	0.816099404	2.35E-30
THYM	TF	RPS6	GTF3A	0.826183093	1.10E-31
THYM	TF	RPS6	THYN1	0.854222121	6.91E-36
THYM	TSG	RPS6	PLEKHO1	0.803169231	9.17E-29
THYM	TSG	RPS6	PARK7	0.811756794	8.31E-30
THYM	TSG	RPS6	PFN1	0.831444031	2.05E-32
THYM	TSG	RPS6	AIP	0.840778146	9.03E-34
THYM	TSG	RPS6	GLTSCR2	0.871324649	6.59E-39
THYM	TSG	RPS6	GNB2L1	0.879702736	1.50E-40
UCS	Cell metabolism gene	RPS6	PSMC3	0.801376789	1.49E-28
UCS	Cell metabolism gene	RPS6	TXN	0.802039572	1.25E-28
UCS	Cell metabolism gene	RPS6	PAFAH1B3	0.802059843	1.24E-28
UCS	Cell metabolism gene	RPS6	DGUOK	0.803892979	7.53E-29
UCS	Cell metabolism gene	RPS6	SNRPD1	0.806823897	3.35E-29
UCS	Cell metabolism gene	RPS6	LSM4	0.808075504	2.36E-29
UCS	Cell metabolism gene	RPS6	TOMM22	0.809640774	1.52E-29
UCS	Cell metabolism gene	RPS6	PSMD13	0.814795227	3.45E-30
UCS	Cell metabolism gene	RPS6	PSMB7	0.815734614	2.62E-30
UCS	Cell metabolism gene	RPS6	SEC61B	0.817449294	1.58E-30
UCS	Cell metabolism gene	RPS6	SNRPF	0.822619886	3.32E-31
UCS	Cell metabolism gene	RPS6	EXOSC1	0.826155734	1.11E-31
UCS	Cell metabolism gene	RPS6	LSM2	0.83120548	2.22E-32
UCS	Cell metabolism gene	RPS6	TIMM8B	0.834696342	7.07E-33
UCS	Cell metabolism gene	RPS6	SNRPD2	0.845824208	1.53E-34
UCS	Cell metabolism gene	RPS6	LSM5	0.851417916	1.99E-35
UCS	Cell metabolism gene	RPS6	FAU	0.85519536	4.77E-36
UCS	CGC	RPS6	NACA	0.805214395	5.23E-29
UCS	Epifactor	RPS6	PPM1G	0.804026565	7.26E-29
UCS	Epifactor	RPS6	FBL	0.806470192	3.70E-29
UCS	Epifactor	RPS6	RUVBL2	0.807017939	3.17E-29
UCS	Epifactor	RPS6	EXOSC1	0.826155734	1.11E-31
UCS	Epifactor	RPS6	RBX1	0.840904951	8.64E-34
UCS	Epifactor	RPS6	TAF10	0.848032709	6.91E-35
UCS	Epifactor	RPS6	SS18L2	0.8645381	1.17E-37
UCS	IUPHAR	RPS6	PPIA	0.821850083	4.20E-31
UCS	TF	RPS6	ZNF444	0.816099404	2.35E-30
UCS	TF	RPS6	GTF3A	0.826183093	1.10E-31
UCS	TF	RPS6	THYN1	0.854222121	6.91E-36
UCS	TSG	RPS6	PLEKHO1	0.803169231	9.17E-29
UCS	TSG	RPS6	PARK7	0.811756794	8.31E-30
UCS	TSG	RPS6	PFN1	0.831444031	2.05E-32
UCS	TSG	RPS6	AIP	0.840778146	9.03E-34
UCS	TSG	RPS6	GLTSCR2	0.871324649	6.59E-39
UCS	TSG	RPS6	GNB2L1	0.879702736	1.50E-40
UVM	Cell metabolism gene	RPS6	TIMM9	0.841661725	1.43E-22
UVM	CGC	RPS6	NACA	0.801454817	4.30E-19
UVM	Epifactor	RPS6	NAP1L1	0.858177785	2.70E-24
UVM	TSG	RPS6	GAS5	0.811060159	7.56E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS6	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS6	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS6	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPS6	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS6	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS6	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS6	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS6	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS6	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS6	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS6	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPS6	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS6	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS6	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS6	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS6	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPS6	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS6	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPS6	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPS6	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS6	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS6	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS6	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS6	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPS6	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPS6	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS6	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS6	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS6

EIF3B, HSP90AA1, TERF2, POT1, DCC, STAU1, EBNA-LP, MTOR, RICTOR, MAPKAP1, RPTOR, PCK1, RAD21, NDRG1, ARRB2, SIRT7, HDAC6, TDRD3, CUL3, CUL4B, CUL5, CUL2, CUL1, COPS5, DCUN1D1, CAND1, RPS6KB1, RPS4X, RPL23, RPL5, RPL7, RPS3A, RPSA, RPLP0, RPL10A, RPL11, RPL12, RPL13, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL24, RPL27A, RPL31, RPL37A, RPL4, RPL6, RPL8, RPS12, RPS14, RPS15A, RPS16, RPS19, RPS20, RPS23, RPS24, RPS25, RPS28, RPS3, RPS5, RPS7, RPS8, RPS2, RPS13, RPL7A, RPL3, RPL30, RPL23A, RPS26, RPS11, RPL9, RPLP1, RPLP2, RPL22, RPS9, EEF2, RPS15, RPL36, RPS17, RPL38, HSP90AB1, RPL32, RPS21, RPL17, RPS27A, RPL29, EEF1A1, FAU, NOP56, FBL, MYBBP1A, NCL, NPM1, HNRNPU, GNL3, NAP1L1, SLC25A5, ILF3, EBNA1BP2, ILF2, HNRNPA1, DHX9, NHP2L1, HNRNPM, NOP58, TUFM, NOLC1, EIF6, RPS27L, RPL10L, RPLP0P6, NOP2, NFIA, HIST1H2AD, VASN, CLINT1, NIFK, HNRNPA0, RRS1, IMPDH2, UPF1, ESR1, MAGOH, EIF4A3, SMURF1, FN1, VCAM1, UBL4A, ITGA4, VHL, PAN2, CD81, IGSF8, ICAM1, PRKACB, PLA2G12A, ATF4, PRKCSH, UPF2, FBXO6, TARDBP, PARK2, GNB2L1, PTOV1, EIF3CL, PNO1, RPS10, RPS18, RPS27, RPS29, SERBP1, SND1, WDR26, WIBG, TSR1, rev, CEP250, TP53, TUBG1, TUBGCP3, VCP, UIMC1, MDM2, CUL7, OBSL1, EIF2A, EIF5, RPS6KB2, NTRK1, EIF5B, RPL10, RPL35, RPL3L, DDX18, PABPC1, RPL13A, RPL26, RPL26L1, RPL27, RPL28, RPL34, RPL35A, LOC101929876, SFN, FRS2, PTEN, gag, XPO1, KIF11, CBX8, NOP9, Eif3a, Eif3e, Eif3i, Rpl35, Srp72, Rrbp1, GAN, CRY2, Mdm2, RC3H1, ZNF746, CNBP, KIAA0020, H2AFX, ZC3HAV1, RPF1, CYLD, TRIM25, BRCA1, LMNA, YAP1, MTF1, USP10, G3BP1, G3BP2, CAPRIN1, ZNF598, RMND5A, HBP1, BMP4, CTNNB1, LARS, MAP2K1, MAP2K3, PCBP1, PPIE, TGFB1, TRIP4, PYHIN1, PRPF8, AAR2, PIH1D1, EFTUD2, RNF4, SHARPIN, CHD3, CHD4, LARP7, TNF, FAM188B, RIOK1, HEXIM1, MEPCE, SNAI1, AGR2, RECQL4, REST, MYC, CDK9, IGF2BP3, MPHOSPH10, URB1, RFC4, RFC3, HADHA, DAP3, RPS6, RPL39, NOP14, RPP30, MRPS34, LACTB, TBL3, DDX10, BYSL, BMS1, WDR43, PWP2, ZKSCAN8, GLYR1, NOM1, NUP188, HP1BP3, NOL9, GPATCH4, RSBN1, DIEXF, NOL8, WDR36, BRIX1, MRPS31, LTV1, POP1, DDX50, C7orf50, NOL10, NOC4L, REPIN1, ESF1, HEATR1, MRPL47, UTP3, DDX21, SDAD1, AATF, USP36, SRP68, MRTO4, ABT1, AKAP8L, DIMT1, WDR3, RCL1, LAS1L, GTF3C3, IPO7, SDHA, C1QBP, KPNB1, POLRMT, PES1, ACACB, NKRF, NVL, RRP8, PRKRA, NPM3, SURF6, UTP20, RSL1D1, SRP72, PARN, SSB, UCHL1, ATP2A2, ARF4, NME2, RFC1, RBM34, MKI67, CTCF, EMD, SLC25A1, HADHB, RRP1, BASP1, MRPS22, MRPS25, MRPS10, MRPS5, MRPS15, MRPS6, MRPS9, RPL36A, EXOSC10, CEBPZ, NSUN2, ECH1, MRPL28, KRR1, PWP1, GNL2, BOP1, SAFB2, TCEB3, RRP1B, PDCD11, LBR, HAGH, KNOP1, MAP7D1, RRP12, PCID2, RPL7L1, C3orf17, CCDC137, LIN28B, DHX30, TRMT1L, MRPL21, DHX37, FTSJ3, PELP1, DDX51, MRPL43, KRI1, NGDN, DDX55, DDX54, NOC3L, SLC39A7, H1FX, MRPS27, NUP205, MRPL24, PTCD3, IMP4, DDX27, ZNF512, PURB, MCCC1, GRWD1, LLPH, UTP23, WDR18, MAK16, MRPL13, MRPS26, MRPL37, GTPBP4, WDR12, REXO4, DDX24, NAT10, GZF1, CCDC86, DHX33, NOL6, C14orf169, RPF2, DDX31, NMNAT1, GRPEL1, ZNF286A, MOV10, PPAN, IMP3, FANCI, RBM28, PAK1IP1, LYAR, TEX10, DDX56, GLTSCR2, MRPL27, BCCIP, RRBP1, NOL12, RSL24D1, NIP7, DDX52, MRPS7, MRPS2, MRPL11, RRP15, NOP16, MRPS16, MRPS23, NOC2L, RBM19, MRPS18B, C1orf106, METTL14, KIAA1429, EIF4B, RC3H2, PHB, RBX1, NR2C2, PPP1CC, KRAS, EIF5A, ATXN3, VRK1, HIST1H4A, ZMYND19, SNRNP70, Dppa3, ITFG1, ARAF, HMGB1, BIRC3, UBAP2L, NFX1, WWP2, BRD7, MATR3, SOX2, ARIH2, PLEKHA4, RAD18, PINK1, HCVgp1, ORF50, ZC3H18, VIM, USP9Y, ZCCHC4, SNIP1, E, M, nsp13, nsp14, nsp4, nsp5, nsp6, ORF3a, ORF6, ORF7a, ORF7b, S, ERCC6, MYOM2, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, LRRC59, NDN, CIC, N, Apc2, RBM39, FBP1, LGALS9, BKRF1, RIN3, DDX58, AR, UFL1, DDRGK1, ELOVL5, LYN, RHOB, ADAR, BBX, BLM, BRD3, BUD13, C12orf43, CCDC59, CDCA8, CENPC, CMSS1, COIL, CWC25, CWF19L2, DCAF13, DDX49, DEK, DKC1, DNAJC8, DNTTIP2, ERICH1, FAM207A, GNAI3, HDGF, ISG20L2, LENG8, LIG3, MECP2, C11orf57, NOL11, WHSC1, WHSC1L1, NUSAP1, PAPD5, PHF10, PHF2, PHIP, PINX1, POLR1E, PSIP1, PSMD4, RAB7A, RBMX2, MINA, SET, SMNDC1, SPTY2D1, SRFBP1, STRBP, SUB1, SUPT16H, TOP1, TOP2A, TOP2B, TPX2, TXNL1, UBTF, UPF3B, URB2, UTP14A, UTP18, WIZ, XRCC6, ZKSCAN4, ZMAT2, ZNF106, ZNF512B, CACTIN, CFDP1, CHAF1A, CXorf56, DDX41, GNL3L, GTF2E2, KIFC1, MFAP1, MYSM1, PDS5B, PGK1, PRPF3, RPP38, RSF1, RTF1, SARNP, SRPK2, WDR70, XRCC1, ZFR, FZR1, PAGE4, NUDCD2, NAA40, TRIM28, VPS33B, ASCC2, ZNF689, ZNF770, ZNF771, ZNF22, CDK12, SRSF12, EPB41L4B, TP53BP2, NSA2, DHX57, HERC5, PRDM15, WDR46, YBX2, YBX1, ZNF7, RBM47, YTHDC2, FARS2, ZCRB1, ZBTB24, GLE1, ZNF668, ZNF189, STAU2, ZBTB11, RPS26P11, MYEF2, NOA1, SREK1, ASCC3, PURG, MRPL52, LARP1B, MRPS35, ELAVL2, SLTM, SRPK1, H1FOO, ZNF768, PRDM10, PPAN-P2RY11, LARP1, ZNF48, TAF1C, VPRBP, MRPL1, ZNF70, CCDC85C, ZNF629, PPP1R13B, PURA, MRPL16, ZCCHC3, ZNF574, YBX3, RSBN1L, SRSF6, ADARB1, SRSF5, TTF1, ZSCAN25, ZNF346, ZFP91, ZC3H3, MRPL57, EPB41L5, FAM111A, RPS4Y2, RPL36AL, HIST1H1A, C8orf33, OASL, XRN1, PHF6, CDC5L, RIOK2, DHX36, ZCCHC9, MRPL40, MRPL9, MRPL23, SPATS2, RPSAP58, TUBA8, APOBEC3F, DAXX, PAF1, MRS2, SPATS2L, HIST2H2AB, HIST1H1E, SPRTN, BTF3, TRIM26, FBXW7, EIF4ENIF1, Htatsf1, NLRP7, RCHY1, CCNF, ZEB1, BRD4,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPS6	chr9	19376346	C	T	single_nucleotide_variant	Uncertain_significance	Hemimegalencephaly	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6	chr9	19376393	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6	chr9	19378520	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS6	PRAD	chr9	19376346	19376346	C	T	Missense_Mutation	p.R232H	4
RPS6	BRCA	chr9	19378776	19378776	C	G	Missense_Mutation	p.K93N	3
RPS6	BRCA	chr9	19380191	19380191	C	T	Missense_Mutation	p.M1I	3
RPS6	PAAD	chr9	19378800	19378800	T	C	Silent	p.R85R	3
RPS6	UCEC	chr9	19378870	19378870	G	T	Missense_Mutation	p.P62H	3
RPS6	ESCA	chr9	19378872	19378872	G	A	Silent	p.F61F	3
RPS6	UCEC	chr9	19376329	19376329	G	A	Nonsense_Mutation	p.R238*	3
RPS6	BLCA	chr9	19376375	19376375	C	G	Missense_Mutation	p.E222D	2
RPS6	UCEC	chr9	19376343	19376343	C	A	Missense_Mutation	p.R233I	2
RPS6	UCEC	chr9	19376499	19376499	C	T	Missense_Mutation	p.R216K	2
RPS6	SKCM	chr9	19378419	19378419	G	A	Missense_Mutation	p.S148F	2
RPS6	UCEC	chr9	19378843	19378843	C	T	Missense_Mutation	p.G71D	2
RPS6	UCEC	chr9	19379552	19379552	A	T	Missense_Mutation	p.L24H	2
RPS6	PAAD	chr9	19378800	19378800	T	C	Silent		2
RPS6	CESC	chr9	19378854	19378854	G	T	Silent		2
RPS6	LIHC	chr9	19378707	19378707	T	-	Splice_Site	p.K116_splice	2
RPS6	BLCA	chr9	19376351	19376351	C	G	Missense_Mutation	p.K230N	2
RPS6	BLCA	chr9	19376356	19376356	C	A	Missense_Mutation	p.A229S	2
RPS6	LUAD	chr9	19379600	19379600	G	A	Missense_Mutation	p.P8L	2
RPS6	BLCA	chr9	19376564	19376564	C	G	Silent	p.L194L	2
RPS6	SARC	chr9	19378401	19378401	C	T	Missense_Mutation		2
RPS6	BLCA	chr9	19376294	19376294	T	C	Silent	p.K249K	2
RPS6	SARC	chr9	19379569	19379569	C	A	Silent		1
RPS6	HNSC	chr9	19378704	19378704	A	T	Splice_Site		1
RPS6	BLCA	chr9	19380154	19380154	C	A	Missense_Mutation		1
RPS6	MESO	chr9	19376613	19376613	C	T	Missense_Mutation		1
RPS6	BLCA	chr9	19376499	19376499	C	G	Missense_Mutation	p.R216T	1
RPS6	SARC	chr9	19379363	19379363	G	T	Missense_Mutation		1
RPS6	LGG	chr9	19378818	19378818	C	T	Silent	p.K79K	1
RPS6	BLCA	chr9	19376564	19376564	C	G	Silent		1
RPS6	MESO	chr9	19376613	19376613	C	T	Missense_Mutation	p.R178H	1
RPS6	BLCA	chr9	19378706	19378707	-	T	Splice_Site	p.G117fs	1
RPS6	LIHC	chr9	19376607	19376607	A	G	Missense_Mutation		1
RPS6	BLCA	chr9	19376294	19376294	T	C	Silent		1
RPS6	OV	chr9	19379608	19379610	GAT	-	In_Frame_Del	p.I5in_frame_del	1
RPS6	SKCM	chr9	19379559	19379559	G	A	Translation_Start_Site		1
RPS6	LIHC	chr9	19378464	19378464	A	G	Missense_Mutation	p.L133P	1
RPS6	BLCA	chr9	19376375	19376375	C	G	Missense_Mutation		1
RPS6	SKCM	chr9	19379560	19379560	T	A	Missense_Mutation	p.E21D	1
RPS6	LIHC	chr9	19376359	19376380	TTTGTTCCTGGCGCTTCTCCTT	-	Frame_Shift_Del	p.221_228del	1
RPS6	BLCA	chr9	19378471	19378471	G	A	Missense_Mutation		1
RPS6	SKCM	chr9	19378784	19378784	C	T	Missense_Mutation	p.E91K	1
RPS6	BLCA	chr9	19378706	19378707	-	-	Frame_Shift_Ins		1
RPS6	CESC	chr9	19376658	19376658	T	G	RNA	NULL	1
RPS6	STAD	chr9	19380184	19380184	C	A	Missense_Mutation		1
RPS6	LIHC	chr9	19379408	19379408	C	-	Frame_Shift_Del	p.G72fs	1
RPS6	READ	chr9	19376543	19376543	T	G	Missense_Mutation	p.K201N	1
RPS6	COAD	chr9	19376572	19376572	T	C	Missense_Mutation	p.I192V	1
RPS6	STAD	chr9	19379526	19379526	C	T	Missense_Mutation	p.A33T	1
RPS6	LUAD	chr9	19378835	19378835	G	T	Missense_Mutation	p.R74S	1
RPS6	READ	chr9	19378482	19378482	G	T	Missense_Mutation	p.T127N	1
RPS6	COAD	chr9	19376575	19376575	G	A	Missense_Mutation	p.R191C	1
RPS6	THYM	chr9	19379600	19379600	G	T	Missense_Mutation	p.P8Q	1
RPS6	COAD	chr9	19376648	19376648	A	G	Silent	p.G166G	1
RPS6	BLCA	chr9	19376351	19376351	C	G	Missense_Mutation		1
RPS6	LUSC	chr9	19376297	19376297	C	A	Missense_Mutation	p.Q248H	1
RPS6	SARC	chr9	19380122	19380122	A	G	Missense_Mutation		1
RPS6	BLCA	chr9	19376356	19376356	C	A	Missense_Mutation		1
RPS6	LUSC	chr9	19378869	19378869	G	A	Silent	p.P62P	1

Copy number variation (CNV) of RPS6
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS6
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
98245	COAD	TCGA-AA-3870-01A	ATG10	chr5	81572049	+	RPS6	chr9	19376617	-
98245	Non-Cancer	TCGA-IP-7968-11A	DSC3	chr18	28576756	-	RPS6	chr9	19378916	-
98245	Non-Cancer	TCGA-IP-7968-11A	DSC3	chr18	28576757	-	RPS6	chr9	19378916	-
98245	N/A	AK027187	DUOXA1	chr15	45410757	-	RPS6	chr9	19380233	-
98245	N/A	BF814212	MALAT1	chr11	65266525	-	RPS6	chr9	19379594	-
98245	N/A	BP428720	MTUS2	chr13	29777696	-	RPS6	chr9	19376253	+
98245	N/A	BG874971	NUP160	chr11	47800689	+	RPS6	chr9	19378842	-
98245	N/A	EC533669	REPS2	chrX	17171353	-	RPS6	chr9	19376630	-
98245	N/A	EC582340	RIMS2	chr8	104781225	-	RPS6	chr9	19376253	+
101205	N/A	AW023980	RPS6	chr9	19376253	-	ABHD3	chr18	19235278	-
83843	N/A	BE257666	RPS6	chr9	19376628	-	C14orf132	chr14	96558852	+
86698	N/A	BG575834	RPS6	chr9	19378458	-	CASP8	chr2	202098783	+
91347	STAD	TCGA-VQ-A94P	RPS6	chr9	19378365	-	DENND4C	chr9	19369834	+
91347	N/A	BG577167	RPS6	chr9	19376258	-	DENND4C	chr9	19248236	-
91347	N/A	CF124853	RPS6	chr9	19376253	-	DENND4C	chr9	19356959	-
90489	OV	TCGA-29-2414	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
78099	N/A	AI547303	RPS6	chr9	19376253	-	EVI5	chr1	93247038	+
91466	N/A	BI857592	RPS6	chr9	19200301	-	FUT8	chr14	65902676	-
93687	N/A	BF514651	RPS6	chr9	19378387	+	GANAB	chr11	62407163	-
86812	PRAD	TCGA-EJ-7328-01A	RPS6	chr9	19376283	-	GNB2L1	chr5	180670914	-
100486	N/A	BG031874	RPS6	chr9	19200295	-	GPCPD1	chr20	5585600	+
78099	N/A	BF843060	RPS6	chr9	19378762	+	IVL	chr1	152884030	+
96740	N/A	BF814502	RPS6	chr9	19379594	+	MALAT1	chr11	65266525	+
78099	N/A	CB857412	RPS6	chr9	19378466	+	NACAD	chr7	45125427	+
90848	N/A	BQ378142	RPS6	chr9	19378367	-	NARS2	chr11	78277177	+
78099	OV	TCGA-13-0801	RPS6	chr9	19380187	-	NCAPG	chr4	17838781	+
95601	N/A	AV697913	RPS6	chr9	19376253	-	NDST3	chr4	118999891	+
100629	N/A	AA553904	RPS6	chr9	19376568	+	NPAS2	chr2	101541622	+
91926	N/A	BM145677	RPS6	chr9	19377415	+	NXF1	chr11	62559645	+
101060	PRAD	TCGA-XQ-A8TA-01A	RPS6	chr9	19376283	-	OAZ1	chr19	2269520	+
89025	N/A	AW023729	RPS6	chr9	19376253	-	PARD6G	chr18	77998849	+
90337	N/A	AA026363	RPS6	chr9	19376587	+	POSTN	chr13	38137332	+
101093	N/A	AA935057	RPS6	chr9	19376253	-	PPFIA2	chr12	81826274	-
80746	UCEC	TCGA-DI-A2QT-01A	RPS6	chr9	19378366	-	RPL23	chr17	37009358	-
101599	N/A	T59674	RPS6	chr9	19376507	+	RPL27	chr17	41150472	+
98245	N/A	AW970974	RPS6	chr9	19376905	-	RPS6	chr9	19376844	+
98245	N/A	CB216724	RPS6	chr9	19378488	+	RPS6	chr9	19378437	-
98245	N/A	CD240216	RPS6	chr9	19376257	-	RPS6	chr9	19376299	+
97595	SKCM	TCGA-D3-A2J7	RPS6	chr9	19379484	-	SRSF4	chr1	29481422	-
102561	OV	TCGA-24-1469	RPS6	chr9	19379484	-	UGGT1	chr2	128918711	+
78099	UCS	TCGA-QM-A5NM	RPS6	chr9	19378365	-	WNK2	chr9	96079801	+
98245	N/A	EC562036	SLC24A2	chr9	19588167	-	RPS6	chr9	19376560	-
98245	COAD	TCGA-AZ-4308-01A	TAF15	chr17	34171938	+	RPS6	chr9	19376388	-
98245	N/A	BE839349	TMEM150C	chr4	83416300	+	RPS6	chr9	19376492	+
98245	STAD	TCGA-D7-8574-01A	TTN	chr2	179443338	-	RPS6	chr9	19378916	-
98245	N/A	AA308629	TUBA8	chr22	18624428	-	RPS6	chr9	19379618	-
98246	STAD	TCGA-BR-8078-01A	VPRBP	chr3	51434155	-	RPS6	chr9	19378859	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	RPS6	0.021348898374974	0.6
KIRC	RPS6	0.0310607701592347	0.84
KIRP	RPS6	0.0481916944867442	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPS6	0.0340526208709701	1
LGG	RPS6	0.0417452106095497	1
BRCA	RPS6	0.0011390283798675	0.038
PAAD	RPS6	0.0427906079606345	1
THYM	RPS6	0.00624566527389336	0.2

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0006142	Malignant neoplasm of breast	1	CTD_human
C0024623	Malignant neoplasm of stomach	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
C2239176	Liver carcinoma	1	CTD_human
C4704874	Mammary Carcinoma, Human	1	CTD_human