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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS6KA3 (NCBI Gene ID:6197)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS6KA3
	Gene ID: 6197
	Gene Symbol	RPS6KA3
	Gene ID	6197
	Gene Name	ribosomal protein S6 kinase A3
	Synonyms	CLS\|HU-3\|ISPK-1\|MAPKAPK1B\|MRX19\|RSK\|RSK2\|S6K-alpha3\|p90-RSK2\|pp90RSK2
	Cytomap	Xp22.12
	Type of Gene	protein-coding
	Description	ribosomal protein S6 kinase alpha-3MAP kinase-activated protein kinase 1bMAPK-activated protein kinase 1bMAPKAP kinase 1bMAPKAPK-1bRSK-2S6K-alpha-3epididymis secretory sperm binding proteininsulin-stimulated protein kinase 1p90-RSK 3ribosomal S6
	Modification date	20200327
	UniProtAcc	P51812

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS6KA3	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	18402937

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS6KA3	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'RPS6KA3[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS6KA3	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000379565	20179761	20179879	Frame-shift
ENST00000379565	20183016	20183178	In-frame
ENST00000379565	20185706	20185865	In-frame
ENST00000379565	20187519	20187609	In-frame
ENST00000379565	20195113	20195202	Frame-shift
ENST00000379565	20205945	20206088	Frame-shift
ENST00000379565	20211604	20211711	Frame-shift
ENST00000379565	20213182	20213263	In-frame
ENST00000379565	20222139	20222221	Frame-shift
ENST00000379565	20227405	20227522	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000379565	20183016	20183178	7935	1811	1972	740	534	588
ENST00000379565	20185706	20185865	7935	1652	1810	740	481	534
ENST00000379565	20187519	20187609	7935	1562	1651	740	451	481
ENST00000379565	20213182	20213263	7935	534	614	740	108	135
ENST00000379565	20227405	20227522	7935	335	451	740	42	81

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P51812	42	81	1	740	Chain	ID=PRO_0000086203;Note=Ribosomal protein S6 kinase alpha-3
P51812	108	135	1	740	Chain	ID=PRO_0000086203;Note=Ribosomal protein S6 kinase alpha-3
P51812	534	588	1	740	Chain	ID=PRO_0000086203;Note=Ribosomal protein S6 kinase alpha-3
P51812	481	534	1	740	Chain	ID=PRO_0000086203;Note=Ribosomal protein S6 kinase alpha-3
P51812	451	481	1	740	Chain	ID=PRO_0000086203;Note=Ribosomal protein S6 kinase alpha-3
P51812	42	81	68	327	Domain	Note=Protein kinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P51812	108	135	68	327	Domain	Note=Protein kinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P51812	534	588	422	679	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P51812	481	534	422	679	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P51812	451	481	422	679	Domain	Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P51812	42	81	74	82	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P51812	534	588	539	539	Active site	Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250
P51812	451	481	451	451	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P51812	481	534	529	529	Modified residue	Note=Phosphotyrosine%3B by FGFR3;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P18654
P51812	534	588	556	556	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18691976;Dbxref=PMID:18691976
P51812	42	81	75	75	Natural variant	ID=VAR_006189;Note=In CLS. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:8955270;Dbxref=dbSNP:rs122454124,PMID:8955270
P51812	108	135	114	114	Natural variant	ID=VAR_006191;Note=In CLS. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:10094187;Dbxref=dbSNP:rs122454127,PMID:10094187
P51812	108	135	115	115	Natural variant	ID=VAR_065892;Note=In MRX19. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17100996;Dbxref=dbSNP:rs387906703,PMID:17100996
P51812	108	135	127	127	Natural variant	ID=VAR_006192;Note=In CLS. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:9837815;Dbxref=PMID:9837815
P51812	451	481	477	477	Natural variant	ID=VAR_065898;Note=In CLS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:15214012;Dbxref=PMID:15214012
P51812	481	534	483	483	Natural variant	ID=VAR_040629;Note=In a gastric adenocarcinoma sample%3B somatic mutation. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs1271090915,PMID:17344846
P51812	451	481	480	480	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
P51812	481	534	494	494	Sequence conflict	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
P51812	42	81	50	54	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5D9L
P51812	42	81	65	67	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NW6
P51812	42	81	68	76	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NW6
P51812	42	81	78	87	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NW6
P51812	108	135	109	124	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NW6
P51812	108	135	133	139	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NW6
P51812	451	481	446	454	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4D9T
P51812	451	481	455	457	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4D9T
P51812	451	481	461	470	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4D9T
P51812	481	534	479	484	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4D9T
P51812	451	481	479	484	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4D9T
P51812	481	534	486	494	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4D9T
P51812	481	534	501	506	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4D9T
P51812	481	534	513	532	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4D9T
P51812	534	588	542	544	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4D9T
P51812	534	588	545	551	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4D9T
P51812	534	588	554	556	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4D9T
P51812	534	588	557	559	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4D9T
P51812	534	588	571	573	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4JG8
P51812	534	588	587	613	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4D9T

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
ESCA	RPS6KA3	1.90799647706234	0.0068359375
UCEC	RPS6KA3	2.22554023919536	0.03125
LUSC	RPS6KA3	-1.92441592334707	8.91464610117726e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
CHOL	RPS6KA3	hsa-miR-15b-5p	96	-0.316864295125165	0.0344092062908856
OV	RPS6KA3	hsa-miR-107	96	-0.301033040211731	0.0305135556560629

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
LGG	RPS6KA3	1	2	0.0181977451088075	0.0421396666666667	0.341034673913043	-0.102845207699325	-0.0350686569747393
READ	RPS6KA3	1	2	0.00747287974066004	0.0365594262295082	0.326756111111111	0.171807764978144	-0.0266938743661556

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
ESCA	RPS6KA3	0.035670673	0.007743659

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS6KA3 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	RPS6KA3	PRKAR2A	0.810373425	1.53E-11
CHOL	Epifactor	RPS6KA3	USP12	0.807654469	2.02E-11
CHOL	IUPHAR	RPS6KA3	PRKAR2A	0.810373425	1.53E-11
CHOL	TSG	RPS6KA3	USP12	0.807654469	2.02E-11
DLBC	Cell metabolism gene	RPS6KA3	NCOA6	0.800541226	8.53E-12
DLBC	Cell metabolism gene	RPS6KA3	AHCYL2	0.802352934	7.06E-12
DLBC	Cell metabolism gene	RPS6KA3	NCOA2	0.804060174	5.90E-12
DLBC	Cell metabolism gene	RPS6KA3	PDPR	0.806483623	4.56E-12
DLBC	Cell metabolism gene	RPS6KA3	MED17	0.81103686	2.78E-12
DLBC	Cell metabolism gene	RPS6KA3	LONP2	0.812328265	2.41E-12
DLBC	Cell metabolism gene	RPS6KA3	SIN3A	0.815181656	1.75E-12
DLBC	Cell metabolism gene	RPS6KA3	PIKFYVE	0.815298201	1.73E-12
DLBC	Cell metabolism gene	RPS6KA3	IQGAP1	0.81555926	1.68E-12
DLBC	Cell metabolism gene	RPS6KA3	MED1	0.819034978	1.13E-12
DLBC	Cell metabolism gene	RPS6KA3	AHCYL1	0.820581711	9.41E-13
DLBC	Cell metabolism gene	RPS6KA3	ENTPD5	0.821230162	8.72E-13
DLBC	Cell metabolism gene	RPS6KA3	ALAD	0.822681942	7.35E-13
DLBC	Cell metabolism gene	RPS6KA3	XRN2	0.823084962	7.01E-13
DLBC	Cell metabolism gene	RPS6KA3	CLOCK	0.826692271	4.55E-13
DLBC	Cell metabolism gene	RPS6KA3	CANX	0.837778407	1.13E-13
DLBC	Cell metabolism gene	RPS6KA3	SMG1	0.844614838	4.53E-14
DLBC	Cell metabolism gene	RPS6KA3	SEC24B	0.846337265	3.58E-14
DLBC	Cell metabolism gene	RPS6KA3	PATL1	0.851697513	1.68E-14
DLBC	Cell metabolism gene	RPS6KA3	SEC31A	0.853971058	1.21E-14
DLBC	Cell metabolism gene	RPS6KA3	MED12	0.856614419	8.17E-15
DLBC	Cell metabolism gene	RPS6KA3	UGCG	0.856671758	8.10E-15
DLBC	Cell metabolism gene	RPS6KA3	PRKAA1	0.859081722	5.64E-15
DLBC	Cell metabolism gene	RPS6KA3	EP300	0.880453256	1.63E-16
DLBC	Cell metabolism gene	RPS6KA3	PIP4K2C	0.884161155	8.23E-17
DLBC	Cell metabolism gene	RPS6KA3	MED14	0.896436788	7.17E-18
DLBC	CGC	RPS6KA3	NCOA2	0.804060174	5.90E-12
DLBC	CGC	RPS6KA3	MLLT10	0.80428971	5.76E-12
DLBC	CGC	RPS6KA3	GOLGA5	0.804848962	5.42E-12
DLBC	CGC	RPS6KA3	TRRAP	0.805173647	5.24E-12
DLBC	CGC	RPS6KA3	BCOR	0.805281151	5.18E-12
DLBC	CGC	RPS6KA3	KDM6A	0.806019597	4.79E-12
DLBC	CGC	RPS6KA3	SF3B1	0.808401765	3.70E-12
DLBC	CGC	RPS6KA3	PTPN11	0.809629469	3.24E-12
DLBC	CGC	RPS6KA3	IL6ST	0.81078503	2.86E-12
DLBC	CGC	RPS6KA3	APC	0.811248985	2.71E-12
DLBC	CGC	RPS6KA3	PPM1D	0.811505701	2.64E-12
DLBC	CGC	RPS6KA3	BRD4	0.811731914	2.57E-12
DLBC	CGC	RPS6KA3	ATM	0.813516388	2.11E-12
DLBC	CGC	RPS6KA3	N4BP2	0.813743208	2.06E-12
DLBC	CGC	RPS6KA3	RGPD3	0.814789855	1.83E-12
DLBC	CGC	RPS6KA3	CBL	0.821140685	8.81E-13
DLBC	CGC	RPS6KA3	AFF4	0.821229967	8.72E-13
DLBC	CGC	RPS6KA3	SH2B3	0.832565249	2.20E-13
DLBC	CGC	RPS6KA3	BIRC6	0.833389352	1.98E-13
DLBC	CGC	RPS6KA3	TCF12	0.833420011	1.98E-13
DLBC	CGC	RPS6KA3	KDM5C	0.834666016	1.69E-13
DLBC	CGC	RPS6KA3	LATS1	0.837261042	1.21E-13
DLBC	CGC	RPS6KA3	ELF4	0.841359326	7.04E-14
DLBC	CGC	RPS6KA3	STRN	0.845413518	4.06E-14
DLBC	CGC	RPS6KA3	MSN	0.847038995	3.24E-14
DLBC	CGC	RPS6KA3	CASP8	0.849741666	2.22E-14
DLBC	CGC	RPS6KA3	ASXL2	0.855771469	9.26E-15
DLBC	CGC	RPS6KA3	MED12	0.856614419	8.17E-15
DLBC	CGC	RPS6KA3	EP300	0.880453256	1.63E-16
DLBC	Epifactor	RPS6KA3	NCOA6	0.800541226	8.53E-12
DLBC	Epifactor	RPS6KA3	CHD8	0.804026325	5.92E-12
DLBC	Epifactor	RPS6KA3	NCOA2	0.804060174	5.90E-12
DLBC	Epifactor	RPS6KA3	RBBP5	0.804239064	5.79E-12
DLBC	Epifactor	RPS6KA3	MLLT10	0.80428971	5.76E-12
DLBC	Epifactor	RPS6KA3	TRRAP	0.805173647	5.24E-12
DLBC	Epifactor	RPS6KA3	BCOR	0.805281151	5.18E-12
DLBC	Epifactor	RPS6KA3	KDM6A	0.806019597	4.79E-12
DLBC	Epifactor	RPS6KA3	IKZF3	0.807461019	4.10E-12
DLBC	Epifactor	RPS6KA3	SF3B1	0.808401765	3.70E-12
DLBC	Epifactor	RPS6KA3	ZNF217	0.808417023	3.70E-12
DLBC	Epifactor	RPS6KA3	ARID4A	0.810621901	2.91E-12
DLBC	Epifactor	RPS6KA3	BRD4	0.811731914	2.57E-12
DLBC	Epifactor	RPS6KA3	ATM	0.813516388	2.11E-12
DLBC	Epifactor	RPS6KA3	SIN3A	0.815181656	1.75E-12
DLBC	Epifactor	RPS6KA3	REST	0.8195673	1.06E-12
DLBC	Epifactor	RPS6KA3	PHF12	0.819667173	1.05E-12
DLBC	Epifactor	RPS6KA3	WDR82	0.824327193	6.05E-13
DLBC	Epifactor	RPS6KA3	NIPBL	0.826023238	4.93E-13
DLBC	Epifactor	RPS6KA3	CLOCK	0.826692271	4.55E-13
DLBC	Epifactor	RPS6KA3	HCFC2	0.827312877	4.22E-13
DLBC	Epifactor	RPS6KA3	EPC1	0.830102966	2.99E-13
DLBC	Epifactor	RPS6KA3	C11orf30	0.830557337	2.83E-13
DLBC	Epifactor	RPS6KA3	KDM5C	0.834666016	1.69E-13
DLBC	Epifactor	RPS6KA3	CHD1	0.83546899	1.52E-13
DLBC	Epifactor	RPS6KA3	SMARCAD1	0.837017173	1.25E-13
DLBC	Epifactor	RPS6KA3	SHPRH	0.837782955	1.13E-13
DLBC	Epifactor	RPS6KA3	ADNP	0.844843272	4.39E-14
DLBC	Epifactor	RPS6KA3	SETD5	0.847407674	3.08E-14
DLBC	Epifactor	RPS6KA3	KDM3B	0.847653526	2.98E-14
DLBC	Epifactor	RPS6KA3	PHF2	0.854991986	1.04E-14
DLBC	Epifactor	RPS6KA3	ASXL2	0.855771469	9.26E-15
DLBC	Epifactor	RPS6KA3	PRKAA1	0.859081722	5.64E-15
DLBC	Epifactor	RPS6KA3	RLIM	0.861585076	3.84E-15
DLBC	Epifactor	RPS6KA3	TAF1	0.864709769	2.35E-15
DLBC	Epifactor	RPS6KA3	UBR2	0.865489811	2.08E-15
DLBC	Epifactor	RPS6KA3	BAZ2A	0.870734646	8.83E-16
DLBC	Epifactor	RPS6KA3	EP300	0.880453256	1.63E-16
DLBC	Epifactor	RPS6KA3	SP1	0.890314958	2.51E-17
DLBC	Epifactor	RPS6KA3	PHF8	0.901330915	2.49E-18
DLBC	IUPHAR	RPS6KA3	STK35	0.800812526	8.29E-12
DLBC	IUPHAR	RPS6KA3	NCOA2	0.804060174	5.90E-12
DLBC	IUPHAR	RPS6KA3	ATP11A	0.805058614	5.30E-12
DLBC	IUPHAR	RPS6KA3	TRRAP	0.805173647	5.24E-12
DLBC	IUPHAR	RPS6KA3	MAP3K2	0.805974798	4.81E-12
DLBC	IUPHAR	RPS6KA3	KDM6A	0.806019597	4.79E-12
DLBC	IUPHAR	RPS6KA3	TTBK2	0.808254521	3.76E-12
DLBC	IUPHAR	RPS6KA3	TNKS2	0.810247428	3.03E-12
DLBC	IUPHAR	RPS6KA3	SLC38A7	0.810591153	2.92E-12
DLBC	IUPHAR	RPS6KA3	IL6ST	0.81078503	2.86E-12
DLBC	IUPHAR	RPS6KA3	PPM1D	0.811505701	2.64E-12
DLBC	IUPHAR	RPS6KA3	BRD4	0.811731914	2.57E-12
DLBC	IUPHAR	RPS6KA3	WNK1	0.811774395	2.56E-12
DLBC	IUPHAR	RPS6KA3	ATM	0.813516388	2.11E-12
DLBC	IUPHAR	RPS6KA3	NIPAL2	0.815193215	1.75E-12
DLBC	IUPHAR	RPS6KA3	PIKFYVE	0.815298201	1.73E-12
DLBC	IUPHAR	RPS6KA3	DPP8	0.815646242	1.66E-12
DLBC	IUPHAR	RPS6KA3	TBK1	0.815863676	1.62E-12
DLBC	IUPHAR	RPS6KA3	PDPK1	0.818753215	1.16E-12
DLBC	IUPHAR	RPS6KA3	ADAM17	0.819403433	1.08E-12
DLBC	IUPHAR	RPS6KA3	OSMR	0.824810122	5.71E-13
DLBC	IUPHAR	RPS6KA3	CLOCK	0.826692271	4.55E-13
DLBC	IUPHAR	RPS6KA3	SLC10A7	0.827393217	4.18E-13
DLBC	IUPHAR	RPS6KA3	SCYL2	0.828778139	3.53E-13
DLBC	IUPHAR	RPS6KA3	ADAM10	0.83163273	2.47E-13
DLBC	IUPHAR	RPS6KA3	BIRC6	0.833389352	1.98E-13
DLBC	IUPHAR	RPS6KA3	KDM5C	0.834666016	1.69E-13
DLBC	IUPHAR	RPS6KA3	LATS1	0.837261042	1.21E-13
DLBC	IUPHAR	RPS6KA3	SMG1	0.844614838	4.53E-14
DLBC	IUPHAR	RPS6KA3	KDM3B	0.847653526	2.98E-14
DLBC	IUPHAR	RPS6KA3	CLCN3	0.847664194	2.97E-14
DLBC	IUPHAR	RPS6KA3	CASP8	0.849741666	2.22E-14
DLBC	IUPHAR	RPS6KA3	SLC30A6	0.851895197	1.63E-14
DLBC	IUPHAR	RPS6KA3	NR2C2	0.8545116	1.12E-14
DLBC	IUPHAR	RPS6KA3	PHF2	0.854991986	1.04E-14
DLBC	IUPHAR	RPS6KA3	UGCG	0.856671758	8.10E-15
DLBC	IUPHAR	RPS6KA3	PRKAA1	0.859081722	5.64E-15
DLBC	IUPHAR	RPS6KA3	HIPK3	0.859417999	5.36E-15
DLBC	IUPHAR	RPS6KA3	TAF1	0.864709769	2.35E-15
DLBC	IUPHAR	RPS6KA3	BAZ2A	0.870734646	8.83E-16
DLBC	IUPHAR	RPS6KA3	EP300	0.880453256	1.63E-16
DLBC	IUPHAR	RPS6KA3	PIP4K2C	0.884161155	8.23E-17
DLBC	IUPHAR	RPS6KA3	ATP2A2	0.885266247	6.69E-17
DLBC	IUPHAR	RPS6KA3	PHF8	0.901330915	2.49E-18
DLBC	Kinase	RPS6KA3	STK35	0.800812526	8.29E-12
DLBC	Kinase	RPS6KA3	TRRAP	0.805173647	5.24E-12
DLBC	Kinase	RPS6KA3	MAP3K2	0.805974798	4.81E-12
DLBC	Kinase	RPS6KA3	TTBK2	0.808254521	3.76E-12
DLBC	Kinase	RPS6KA3	BRD4	0.811731914	2.57E-12
DLBC	Kinase	RPS6KA3	WNK1	0.811774395	2.56E-12
DLBC	Kinase	RPS6KA3	ATM	0.813516388	2.11E-12
DLBC	Kinase	RPS6KA3	TBK1	0.815863676	1.62E-12
DLBC	Kinase	RPS6KA3	PDPK1	0.818753215	1.16E-12
DLBC	Kinase	RPS6KA3	SCYL2	0.828778139	3.53E-13
DLBC	Kinase	RPS6KA3	LATS1	0.837261042	1.21E-13
DLBC	Kinase	RPS6KA3	SMG1	0.844614838	4.53E-14
DLBC	Kinase	RPS6KA3	PRKAA1	0.859081722	5.64E-15
DLBC	Kinase	RPS6KA3	HIPK3	0.859417999	5.36E-15
DLBC	Kinase	RPS6KA3	TAF1	0.864709769	2.35E-15
DLBC	TF	RPS6KA3	ZNF136	0.80197571	7.34E-12
DLBC	TF	RPS6KA3	AHCTF1	0.802110614	7.24E-12
DLBC	TF	RPS6KA3	NCOA2	0.804060174	5.90E-12
DLBC	TF	RPS6KA3	IKZF3	0.807461019	4.10E-12
DLBC	TF	RPS6KA3	ZNF217	0.808417023	3.70E-12
DLBC	TF	RPS6KA3	ZNF426	0.809840093	3.17E-12
DLBC	TF	RPS6KA3	ZNF567	0.810038559	3.10E-12
DLBC	TF	RPS6KA3	ELK3	0.811257496	2.71E-12
DLBC	TF	RPS6KA3	PRR12	0.812321069	2.41E-12
DLBC	TF	RPS6KA3	ZNF611	0.816259146	1.55E-12
DLBC	TF	RPS6KA3	REST	0.8195673	1.06E-12
DLBC	TF	RPS6KA3	FOXN2	0.821950643	8.01E-13
DLBC	TF	RPS6KA3	E2F3	0.822354354	7.64E-13
DLBC	TF	RPS6KA3	HIVEP1	0.822434748	7.57E-13
DLBC	TF	RPS6KA3	CLOCK	0.826692271	4.55E-13
DLBC	TF	RPS6KA3	ZNF432	0.826938593	4.41E-13
DLBC	TF	RPS6KA3	TCF12	0.833420011	1.98E-13
DLBC	TF	RPS6KA3	ZNF548	0.835859047	1.45E-13
DLBC	TF	RPS6KA3	ZNF689	0.836380758	1.35E-13
DLBC	TF	RPS6KA3	ZBTB39	0.838164983	1.07E-13
DLBC	TF	RPS6KA3	ZNF281	0.840872449	7.51E-14
DLBC	TF	RPS6KA3	ELF4	0.841359326	7.04E-14
DLBC	TF	RPS6KA3	RREB1	0.843090543	5.57E-14
DLBC	TF	RPS6KA3	ADNP	0.844843272	4.39E-14
DLBC	TF	RPS6KA3	ELF2	0.84494699	4.33E-14
DLBC	TF	RPS6KA3	SP2	0.846370047	3.56E-14
DLBC	TF	RPS6KA3	ATF7	0.848060789	2.81E-14
DLBC	TF	RPS6KA3	NR2C2	0.8545116	1.12E-14
DLBC	TF	RPS6KA3	ELK1	0.869247095	1.13E-15
DLBC	TF	RPS6KA3	BAZ2A	0.870734646	8.83E-16
DLBC	TF	RPS6KA3	ZFX	0.872658983	6.39E-16
DLBC	TF	RPS6KA3	CSRNP2	0.882919074	1.04E-16
DLBC	TF	RPS6KA3	SP1	0.890314958	2.51E-17
DLBC	TF	RPS6KA3	ZNF41	0.928871013	1.81E-21
DLBC	TSG	RPS6KA3	PLXNC1	0.804686713	5.52E-12
DLBC	TSG	RPS6KA3	KDM6A	0.806019597	4.79E-12
DLBC	TSG	RPS6KA3	IKZF3	0.807461019	4.10E-12
DLBC	TSG	RPS6KA3	PTPN11	0.809629469	3.24E-12
DLBC	TSG	RPS6KA3	APC	0.811248985	2.71E-12
DLBC	TSG	RPS6KA3	ATM	0.813516388	2.11E-12
DLBC	TSG	RPS6KA3	RBL1	0.81721205	1.39E-12
DLBC	TSG	RPS6KA3	AHCYL1	0.820581711	9.41E-13
DLBC	TSG	RPS6KA3	CBL	0.821140685	8.81E-13
DLBC	TSG	RPS6KA3	E2F3	0.822354354	7.64E-13
DLBC	TSG	RPS6KA3	HIVEP1	0.822434748	7.57E-13
DLBC	TSG	RPS6KA3	RASSF3	0.826028827	4.93E-13
DLBC	TSG	RPS6KA3	SH2B3	0.832565249	2.20E-13
DLBC	TSG	RPS6KA3	CHD1	0.83546899	1.52E-13
DLBC	TSG	RPS6KA3	LATS1	0.837261042	1.21E-13
DLBC	TSG	RPS6KA3	SHPRH	0.837782955	1.13E-13
DLBC	TSG	RPS6KA3	DCLRE1A	0.842680528	5.89E-14
DLBC	TSG	RPS6KA3	KDM3B	0.847653526	2.98E-14
DLBC	TSG	RPS6KA3	CASP8	0.849741666	2.22E-14
DLBC	TSG	RPS6KA3	RNF111	0.851774143	1.66E-14
DLBC	TSG	RPS6KA3	NR2C2	0.8545116	1.12E-14
DLBC	TSG	RPS6KA3	PRKAA1	0.859081722	5.64E-15
PAAD	Epifactor	RPS6KA3	USP12	0.806065116	4.29E-43
PAAD	TF	RPS6KA3	ZNF791	0.804967386	6.77E-43
PAAD	TSG	RPS6KA3	USP12	0.806065116	4.29E-43
TGCT	TF	RPS6KA3	ZBTB38	0.803448878	1.65E-36
THYM	Cell metabolism gene	RPS6KA3	MTR	0.8005227	1.88E-28
THYM	Cell metabolism gene	RPS6KA3	POLR2B	0.80460266	6.19E-29
THYM	Cell metabolism gene	RPS6KA3	PNPLA8	0.804829634	5.82E-29
THYM	Cell metabolism gene	RPS6KA3	B3GNT2	0.805398445	4.97E-29
THYM	Cell metabolism gene	RPS6KA3	PRKAA1	0.806666168	3.50E-29
THYM	Cell metabolism gene	RPS6KA3	GLS	0.807739167	2.59E-29
THYM	Cell metabolism gene	RPS6KA3	MAT2B	0.819048582	9.79E-31
THYM	Cell metabolism gene	RPS6KA3	MTM1	0.831212088	2.21E-32
THYM	Cell metabolism gene	RPS6KA3	PIKFYVE	0.860636665	5.68E-37
THYM	Cell metabolism gene	RPS6KA3	ARFGEF2	0.86309878	2.10E-37
THYM	CGC	RPS6KA3	ATM	0.808652113	2.01E-29
THYM	CGC	RPS6KA3	NUP98	0.809392252	1.63E-29
THYM	CGC	RPS6KA3	ATR	0.833634829	1.00E-32
THYM	CGC	RPS6KA3	CDC73	0.841870425	6.18E-34
THYM	CGC	RPS6KA3	ERCC4	0.842295752	5.33E-34
THYM	Epifactor	RPS6KA3	GLYR1	0.80298358	9.65E-29
THYM	Epifactor	RPS6KA3	PRKAA1	0.806666168	3.50E-29
THYM	Epifactor	RPS6KA3	CHD6	0.807793817	2.55E-29
THYM	Epifactor	RPS6KA3	ATM	0.808652113	2.01E-29
THYM	Epifactor	RPS6KA3	TAF4	0.818091417	1.30E-30
THYM	Epifactor	RPS6KA3	EPC1	0.820486608	6.35E-31
THYM	Epifactor	RPS6KA3	RBBP5	0.825021147	1.58E-31
THYM	Epifactor	RPS6KA3	ARID4B	0.828312907	5.61E-32
THYM	Epifactor	RPS6KA3	DDX21	0.828927838	4.61E-32
THYM	Epifactor	RPS6KA3	SMARCAD1	0.832003851	1.71E-32
THYM	Epifactor	RPS6KA3	ATR	0.833634829	1.00E-32
THYM	Epifactor	RPS6KA3	ADNP	0.834631998	7.22E-33
THYM	Epifactor	RPS6KA3	CDC73	0.841870425	6.18E-34
THYM	Epifactor	RPS6KA3	TAF2	0.854386608	6.50E-36
THYM	Epifactor	RPS6KA3	JMJD1C	0.859280134	9.73E-37
THYM	Epifactor	RPS6KA3	TAF1	0.862238334	2.98E-37
THYM	Epifactor	RPS6KA3	ZNF217	0.870349478	1.01E-38
THYM	IUPHAR	RPS6KA3	MTR	0.8005227	1.88E-28
THYM	IUPHAR	RPS6KA3	MAPK8	0.801548724	1.42E-28
THYM	IUPHAR	RPS6KA3	PRKAA1	0.806666168	3.50E-29
THYM	IUPHAR	RPS6KA3	PRMT3	0.807101242	3.10E-29
THYM	IUPHAR	RPS6KA3	GLS	0.807739167	2.59E-29
THYM	IUPHAR	RPS6KA3	ATM	0.808652113	2.01E-29
THYM	IUPHAR	RPS6KA3	TPP2	0.808732527	1.96E-29
THYM	IUPHAR	RPS6KA3	DPP8	0.809010368	1.81E-29
THYM	IUPHAR	RPS6KA3	NEK7	0.811368539	9.28E-30
THYM	IUPHAR	RPS6KA3	SLK	0.818174525	1.27E-30
THYM	IUPHAR	RPS6KA3	CDK13	0.820955832	5.51E-31
THYM	IUPHAR	RPS6KA3	WNK1	0.828217238	5.78E-32
THYM	IUPHAR	RPS6KA3	ATR	0.833634829	1.00E-32
THYM	IUPHAR	RPS6KA3	NR2C2	0.837181968	3.08E-33
THYM	IUPHAR	RPS6KA3	IDE	0.856187297	3.26E-36
THYM	IUPHAR	RPS6KA3	JMJD1C	0.859280134	9.73E-37
THYM	IUPHAR	RPS6KA3	PIKFYVE	0.860636665	5.68E-37
THYM	IUPHAR	RPS6KA3	TAF1	0.862238334	2.98E-37
THYM	Kinase	RPS6KA3	MAPK8	0.801548724	1.42E-28
THYM	Kinase	RPS6KA3	PRKAA1	0.806666168	3.50E-29
THYM	Kinase	RPS6KA3	ATM	0.808652113	2.01E-29
THYM	Kinase	RPS6KA3	NEK7	0.811368539	9.28E-30
THYM	Kinase	RPS6KA3	SLK	0.818174525	1.27E-30
THYM	Kinase	RPS6KA3	CDK13	0.820955832	5.51E-31
THYM	Kinase	RPS6KA3	WNK1	0.828217238	5.78E-32
THYM	Kinase	RPS6KA3	ATR	0.833634829	1.00E-32
THYM	Kinase	RPS6KA3	TAF1	0.862238334	2.98E-37
THYM	TF	RPS6KA3	ZNF146	0.800045253	2.13E-28
THYM	TF	RPS6KA3	GLYR1	0.80298358	9.65E-29
THYM	TF	RPS6KA3	PRMT3	0.807101242	3.10E-29
THYM	TF	RPS6KA3	ZNF236	0.808379354	2.17E-29
THYM	TF	RPS6KA3	ZSCAN29	0.810916434	1.06E-29
THYM	TF	RPS6KA3	IRF2	0.812696361	6.34E-30
THYM	TF	RPS6KA3	ZNF430	0.813293139	5.33E-30
THYM	TF	RPS6KA3	ZNF280C	0.817723778	1.45E-30
THYM	TF	RPS6KA3	ZNF28	0.820160037	7.01E-31
THYM	TF	RPS6KA3	AHCTF1	0.821650052	4.46E-31
THYM	TF	RPS6KA3	ZBTB1	0.825596922	1.32E-31
THYM	TF	RPS6KA3	ADNP	0.834631998	7.22E-33
THYM	TF	RPS6KA3	ZNF41	0.834928547	6.54E-33
THYM	TF	RPS6KA3	NR2C2	0.837181968	3.08E-33
THYM	TF	RPS6KA3	ZNF217	0.870349478	1.01E-38
THYM	TSG	RPS6KA3	TANK	0.804415856	6.52E-29
THYM	TSG	RPS6KA3	PRKAA1	0.806666168	3.50E-29
THYM	TSG	RPS6KA3	ATM	0.808652113	2.01E-29
THYM	TSG	RPS6KA3	NUP98	0.809392252	1.63E-29
THYM	TSG	RPS6KA3	ATR	0.833634829	1.00E-32
THYM	TSG	RPS6KA3	NR2C2	0.837181968	3.08E-33
THYM	TSG	RPS6KA3	CDC73	0.841870425	6.18E-34
UCS	Cell metabolism gene	RPS6KA3	MTR	0.8005227	1.88E-28
UCS	Cell metabolism gene	RPS6KA3	POLR2B	0.80460266	6.19E-29
UCS	Cell metabolism gene	RPS6KA3	PNPLA8	0.804829634	5.82E-29
UCS	Cell metabolism gene	RPS6KA3	B3GNT2	0.805398445	4.97E-29
UCS	Cell metabolism gene	RPS6KA3	PRKAA1	0.806666168	3.50E-29
UCS	Cell metabolism gene	RPS6KA3	GLS	0.807739167	2.59E-29
UCS	Cell metabolism gene	RPS6KA3	MAT2B	0.819048582	9.79E-31
UCS	Cell metabolism gene	RPS6KA3	MTM1	0.831212088	2.21E-32
UCS	Cell metabolism gene	RPS6KA3	PIKFYVE	0.860636665	5.68E-37
UCS	Cell metabolism gene	RPS6KA3	ARFGEF2	0.86309878	2.10E-37
UCS	CGC	RPS6KA3	ATM	0.808652113	2.01E-29
UCS	CGC	RPS6KA3	NUP98	0.809392252	1.63E-29
UCS	CGC	RPS6KA3	ATR	0.833634829	1.00E-32
UCS	CGC	RPS6KA3	CDC73	0.841870425	6.18E-34
UCS	CGC	RPS6KA3	ERCC4	0.842295752	5.33E-34
UCS	Epifactor	RPS6KA3	GLYR1	0.80298358	9.65E-29
UCS	Epifactor	RPS6KA3	PRKAA1	0.806666168	3.50E-29
UCS	Epifactor	RPS6KA3	CHD6	0.807793817	2.55E-29
UCS	Epifactor	RPS6KA3	ATM	0.808652113	2.01E-29
UCS	Epifactor	RPS6KA3	TAF4	0.818091417	1.30E-30
UCS	Epifactor	RPS6KA3	EPC1	0.820486608	6.35E-31
UCS	Epifactor	RPS6KA3	RBBP5	0.825021147	1.58E-31
UCS	Epifactor	RPS6KA3	ARID4B	0.828312907	5.61E-32
UCS	Epifactor	RPS6KA3	DDX21	0.828927838	4.61E-32
UCS	Epifactor	RPS6KA3	SMARCAD1	0.832003851	1.71E-32
UCS	Epifactor	RPS6KA3	ATR	0.833634829	1.00E-32
UCS	Epifactor	RPS6KA3	ADNP	0.834631998	7.22E-33
UCS	Epifactor	RPS6KA3	CDC73	0.841870425	6.18E-34
UCS	Epifactor	RPS6KA3	TAF2	0.854386608	6.50E-36
UCS	Epifactor	RPS6KA3	JMJD1C	0.859280134	9.73E-37
UCS	Epifactor	RPS6KA3	TAF1	0.862238334	2.98E-37
UCS	Epifactor	RPS6KA3	ZNF217	0.870349478	1.01E-38
UCS	IUPHAR	RPS6KA3	MTR	0.8005227	1.88E-28
UCS	IUPHAR	RPS6KA3	MAPK8	0.801548724	1.42E-28
UCS	IUPHAR	RPS6KA3	PRKAA1	0.806666168	3.50E-29
UCS	IUPHAR	RPS6KA3	PRMT3	0.807101242	3.10E-29
UCS	IUPHAR	RPS6KA3	GLS	0.807739167	2.59E-29
UCS	IUPHAR	RPS6KA3	ATM	0.808652113	2.01E-29
UCS	IUPHAR	RPS6KA3	TPP2	0.808732527	1.96E-29
UCS	IUPHAR	RPS6KA3	DPP8	0.809010368	1.81E-29
UCS	IUPHAR	RPS6KA3	NEK7	0.811368539	9.28E-30
UCS	IUPHAR	RPS6KA3	SLK	0.818174525	1.27E-30
UCS	IUPHAR	RPS6KA3	CDK13	0.820955832	5.51E-31
UCS	IUPHAR	RPS6KA3	WNK1	0.828217238	5.78E-32
UCS	IUPHAR	RPS6KA3	ATR	0.833634829	1.00E-32
UCS	IUPHAR	RPS6KA3	NR2C2	0.837181968	3.08E-33
UCS	IUPHAR	RPS6KA3	IDE	0.856187297	3.26E-36
UCS	IUPHAR	RPS6KA3	JMJD1C	0.859280134	9.73E-37
UCS	IUPHAR	RPS6KA3	PIKFYVE	0.860636665	5.68E-37
UCS	IUPHAR	RPS6KA3	TAF1	0.862238334	2.98E-37
UCS	Kinase	RPS6KA3	MAPK8	0.801548724	1.42E-28
UCS	Kinase	RPS6KA3	PRKAA1	0.806666168	3.50E-29
UCS	Kinase	RPS6KA3	ATM	0.808652113	2.01E-29
UCS	Kinase	RPS6KA3	NEK7	0.811368539	9.28E-30
UCS	Kinase	RPS6KA3	SLK	0.818174525	1.27E-30
UCS	Kinase	RPS6KA3	CDK13	0.820955832	5.51E-31
UCS	Kinase	RPS6KA3	WNK1	0.828217238	5.78E-32
UCS	Kinase	RPS6KA3	ATR	0.833634829	1.00E-32
UCS	Kinase	RPS6KA3	TAF1	0.862238334	2.98E-37
UCS	TF	RPS6KA3	ZNF146	0.800045253	2.13E-28
UCS	TF	RPS6KA3	GLYR1	0.80298358	9.65E-29
UCS	TF	RPS6KA3	PRMT3	0.807101242	3.10E-29
UCS	TF	RPS6KA3	ZNF236	0.808379354	2.17E-29
UCS	TF	RPS6KA3	ZSCAN29	0.810916434	1.06E-29
UCS	TF	RPS6KA3	IRF2	0.812696361	6.34E-30
UCS	TF	RPS6KA3	ZNF430	0.813293139	5.33E-30
UCS	TF	RPS6KA3	ZNF280C	0.817723778	1.45E-30
UCS	TF	RPS6KA3	ZNF28	0.820160037	7.01E-31
UCS	TF	RPS6KA3	AHCTF1	0.821650052	4.46E-31
UCS	TF	RPS6KA3	ZBTB1	0.825596922	1.32E-31
UCS	TF	RPS6KA3	ADNP	0.834631998	7.22E-33
UCS	TF	RPS6KA3	ZNF41	0.834928547	6.54E-33
UCS	TF	RPS6KA3	NR2C2	0.837181968	3.08E-33
UCS	TF	RPS6KA3	ZNF217	0.870349478	1.01E-38
UCS	TSG	RPS6KA3	TANK	0.804415856	6.52E-29
UCS	TSG	RPS6KA3	PRKAA1	0.806666168	3.50E-29
UCS	TSG	RPS6KA3	ATM	0.808652113	2.01E-29
UCS	TSG	RPS6KA3	NUP98	0.809392252	1.63E-29
UCS	TSG	RPS6KA3	ATR	0.833634829	1.00E-32
UCS	TSG	RPS6KA3	NR2C2	0.837181968	3.08E-33
UCS	TSG	RPS6KA3	CDC73	0.841870425	6.18E-34
UVM	CGC	RPS6KA3	MALT1	0.807487738	1.46E-19
UVM	IUPHAR	RPS6KA3	MALT1	0.807487738	1.46E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRC	RPS6KA3	RPS6	-3.4556058277803	0.0001224322154943
KICH	RPS6KA3	MAPK1	1.27319002595358	0.000911891460418701
BRCA	RPS6KA3	MAPK3	-1.61909976139263	0.00193136402459222
ESCA	RPS6KA3	TSC2	-3.24919207627469	0.001953125
KIRP	RPS6KA3	CEBPB	-1.31145810412787	0.00222697434946895
THCA	RPS6KA3	RPS6	1.46346143665389	0.00305071956645465
CHOL	RPS6KA3	CEBPB	-2.23026265318088	0.00390625
CHOL	RPS6KA3	MAPK3	-1.54068193424676	0.00390625
PRAD	RPS6KA3	PDPK1	1.81554957286714	0.00394734627371092
LIHC	RPS6KA3	PDPK1	-1.27273782890459	0.00401886677001472
BLCA	RPS6KA3	RPS6KA1	-4.84274368715488	0.00532913208007812
LUAD	RPS6KA3	PDPK1	-2.39037258175029	0.00557540274754635
LUSC	RPS6KA3	TSC2	1.12504498503233	0.00646935999315137
CHOL	RPS6KA3	CREB1	-1.73574177704588	0.0078125
HNSC	RPS6KA3	CEBPB	1.51100858014832	0.00830558335451315
STAD	RPS6KA3	SRF	-1.21679082976381	0.0105091729201376
KIRP	RPS6KA3	RPS6	-1.15360907834159	0.0111397774890065
COAD	RPS6KA3	RPS6	1.03379589520851	0.011966735124588
BLCA	RPS6KA3	RPS6	-1.76940777579938	0.012359619140625
UCEC	RPS6KA3	PDPK1	1.79218384802367	0.015625
BLCA	RPS6KA3	PDPK1	1.31186516278878	0.0159721374511719
STAD	RPS6KA3	TSC2	-1.66130396745917	0.018431528005749
ESCA	RPS6KA3	MAPK1	-1.17755474324053	0.0185546875
LUSC	RPS6KA3	MAPK7	-3.35738604760991	0.0224634242646672
KICH	RPS6KA3	MAPK7	1.21718138105533	0.0236499309539795
STAD	RPS6KA3	MAPK7	-1.29638436162927	0.0240015927702189
ESCA	RPS6KA3	PDPK1	-1.08809436254042	0.0244140625
LUSC	RPS6KA3	SRF	-1.0334649936822	0.042422086338245
BRCA	RPS6KA3	MAPK1	-1.67954875219151	0.0427276834041307
KIRC	RPS6KA3	MAPK7	-2.4310338713814	1.13043822799662e-08
KICH	RPS6KA3	CREB1	2.66739528597454	1.19209289550781e-07
COAD	RPS6KA3	CEBPB	-3.63250426415859	1.2814998626709e-06
KIRC	RPS6KA3	CEBPB	-1.43820294684797	1.51909432999383e-08
LUAD	RPS6KA3	RPS6KA1	-1.01040747754576	2.07702654013452e-08
LIHC	RPS6KA3	TSC2	-2.06124259504281	3.59406613648813e-06
KIRC	RPS6KA3	PDPK1	-1.27456564339616	4.74133731393022e-07
PRAD	RPS6KA3	MAPK7	1.49805690212541	4.96791357949384e-05
PRAD	RPS6KA3	SRF	-1.15349854635654	4.96791357949384e-05
COAD	RPS6KA3	MAPK3	-1.17173283146352	5.66244125366212e-07
KICH	RPS6KA3	TSC2	-5.67340295495929	6.36577606201172e-05
PRAD	RPS6KA3	CEBPB	1.66039893355835	6.51372327512043e-05
BRCA	RPS6KA3	RPS6KA1	-2.37273780187266	7.30357937454372e-11
KICH	RPS6KA3	PDPK1	1.47618241053961	7.49826431274414e-05
LUSC	RPS6KA3	RPS6KA1	-2.50439479306233	7.57048857587633e-10
LUSC	RPS6KA3	CEBPB	-2.38421489160172	9.46872220956927e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS6KA3

PEA15, CREBBP, MAPK1, MAPK3, PDPK1, MAPK14, H2AFX, NEDD4, EIF3C, ATP5J, BARX1, MASP1, SMS, ESR1, YBX1, NFATC1, NFKBIA, TRAF2, MAPT, HSP90AA1, HIST1H3A, HMGN1, FGFR1, DFFA, HSPA8, NAPRT, RASAL1, CSE1L, GDA, NPEPPS, TGM2, SLC9A3R1, RPS6KA1, EGFR, ZMYM5, KIAA1456, TMEM139, HNRNPH1, STIP1, NTRK1, GBA, Max, Setd3, CDC37, MISP, FGFR2, FYN, TRIM11, IL17RA, WDYHV1, SPRED2, PPP6R2, STRADB, NDEL1, IRGC, ORF45, ILKAP, FGFR3, SRC, FBXO7, TMPO, FOXN2, TP53, NR2C2, HDAC2, GRSF1, AP2A2, GTSE1, LTN1, DOCK4, NME2, SCRIB, AP2M1, CSNK2A2, ARHGEF12, FRS2, KDELR2, RPL37, UTP18, AGPAT1, GTPBP1, LMF2, CTBP1, GGA2, SFXN2, UBE2D3, CTNND1, P2RY6, PTPN3, PLEKHA4, RPS6KA2, PRPS1, HSPA9, HSPA6, HSP90AB1, HSPA1A, HSPB1, BAG2, PGAM5, HSPA5, HSPH1, NCL, H3F3C, HIST2H3C, HIST3H3, H3F3A, HMGA1, HIST1H1D, HSP90AB2P, CCAR2, HNRNPA1L2, HNRNPA1, HIST4H4, HIST1H2AC, HIST3H2A, HIST1H2AE, HNRNPA2B1, HIST1H1E, NPM1, HNRNPM, RBBP4, HIST1H2BB, HIST2H2BE, HIST1H2BJ, CSNK2A1, CSNK2B, SF3B4, HNRNPU, HIST1H2BO, CSNK2A3, PRKAR1A, RPS6KA3, DCP1A, BCAR1, SUMO2, COPS5, CLIP1, KRAS, AMHR2, DGCR2, SLC9A3R2, APBA1, ROCK2, ADAM18, DNASE1L1, SERBP1, ECE2, SLURP1, METTL21B, TMPRSS4, ATM, STAT3,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPS6KA3	chrX	20173245	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
RPS6KA3	chrX	20173542	TA	T	Deletion	Pathogenic	Coffin-Lowry_syndrome	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS6KA3	chrX	20173546	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20173553	C	T	single_nucleotide_variant	Pathogenic/Likely_pathogenic	Intellectual_disability\|Coffin-Lowry_syndrome\|Inborn_genetic_diseases\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20173554	G	A	single_nucleotide_variant	Pathogenic/Likely_pathogenic	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20173571	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Intellectual_disability\|Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome\|History_of_neurodevelopmental_disorder\|not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20173594	TG	T	Deletion	Pathogenic	Coffin-Lowry_syndrome	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS6KA3	chrX	20173694	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20174010	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20174254	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20174262	G	A	single_nucleotide_variant	Pathogenic	Coffin-Lowry_syndrome	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20174285	T	C	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_X-linked_19	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20174331	G	A	single_nucleotide_variant	Pathogenic	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20174338	G	A	single_nucleotide_variant	Benign/Likely_benign	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome\|History_of_neurodevelopmental_disorder\|not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20174348	A	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20174357	G	C	single_nucleotide_variant	Pathogenic	Inborn_genetic_diseases	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20174359	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20174362	CA	C	Deletion	Likely_pathogenic	Coffin-Lowry_syndrome	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS6KA3	chrX	20174370	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20179759	T	TA	Duplication	Conflicting_interpretations_of_pathogenicity	Global_developmental_delay\|Coffin-Lowry_syndrome	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RPS6KA3	chrX	20179759	TA	T	Deletion	Pathogenic	not_provided	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RPS6KA3	chrX	20179787	C	T	single_nucleotide_variant	Pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20179821	C	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20179827	G	A	single_nucleotide_variant	Pathogenic	Coffin-Lowry_syndrome\|not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20179837	T	A	single_nucleotide_variant	Benign/Likely_benign	not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20179844	G	A	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20179875	TG	T	Deletion	Pathogenic	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20180179	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20180817	G	GGT	Microsatellite	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20180920	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20181092	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20181097	T	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20181100	A	C	single_nucleotide_variant	Likely_pathogenic	Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20181125	C	T	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20181160	T	G	single_nucleotide_variant	Pathogenic	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
RPS6KA3	chrX	20182795	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20182862	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20183019	C	G	single_nucleotide_variant	Likely_pathogenic	Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20183040	T	C	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20183082	G	A	single_nucleotide_variant	Pathogenic	Inborn_genetic_diseases	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20183093	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20183103	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20183120	G	A	single_nucleotide_variant	Pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20183148	T	C	single_nucleotide_variant	Uncertain_significance	Inborn_genetic_diseases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20183168	CT	C	Deletion	Pathogenic	Inborn_genetic_diseases	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS6KA3	chrX	20183175	C	A	single_nucleotide_variant	Pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20183183	T	C	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20185722	A	C	single_nucleotide_variant	Pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20185766	CTCGT	C	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS6KA3	chrX	20185787	G	A	single_nucleotide_variant	Pathogenic	Macrocephalus\|Dolichocephaly\|Delayed_speech_and_language_development\|Global_developmental_delay\|Motor_delay\|Thick_vermilion_border\|Muscular_hypotonia	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20185802	C	G	single_nucleotide_variant	Likely_pathogenic	Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20185842	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20185844	CAT	C	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS6KA3	chrX	20185849	T	A	single_nucleotide_variant	Uncertain_significance	Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20185869	T	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20185870	A	G	single_nucleotide_variant	Likely_benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20185939	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20186113	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20187266	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20187514	A	G	single_nucleotide_variant	Uncertain_significance	Coffin-Lowry_syndrome	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20187532	GATA	G	Deletion	Pathogenic	Coffin-Lowry_syndrome	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
RPS6KA3	chrX	20187582	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20187583	T	C	single_nucleotide_variant	Likely_benign	History_of_neurodevelopmental_disorder	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20187587	T	A	single_nucleotide_variant	Likely_pathogenic	Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20190883	T	C	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20190909	G	T	single_nucleotide_variant	Likely_pathogenic	Coffin-Lowry_syndrome	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20190909	GCAAA	G	Deletion	Pathogenic	Mental_retardation,_X-linked_19	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS6KA3	chrX	20190971	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20190975	G	A	single_nucleotide_variant	Likely_benign	History_of_neurodevelopmental_disorder\|not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20190980	T	C	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20191552	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20193158	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20193273	T	A	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_X-linked_19	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20193297	T	C	single_nucleotide_variant	Benign	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20193356	AC	A	Deletion	Pathogenic	Coffin-Lowry_syndrome	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS6KA3	chrX	20193358	C	A	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20193362	G	A	single_nucleotide_variant	Pathogenic	Mental_retardation,_X-linked_19	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20193366	A	G	single_nucleotide_variant	Likely_benign	History_of_neurodevelopmental_disorder	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20193614	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20194384	A	G	single_nucleotide_variant	Likely_benign	History_of_neurodevelopmental_disorder	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20194390	C	T	single_nucleotide_variant	Benign/Likely_benign	History_of_neurodevelopmental_disorder\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20194446	G	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20194447	A	G	single_nucleotide_variant	Benign	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome\|History_of_neurodevelopmental_disorder\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20194461	T	C	single_nucleotide_variant	Likely_pathogenic	Intellectual_disability	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20194466	A	G	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20194472	T	C	single_nucleotide_variant	Pathogenic	Coffin-Lowry_syndrome	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
RPS6KA3	chrX	20194477	G	A	single_nucleotide_variant	Likely_benign	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20194479	G	GA	Duplication	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20194544	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20194549	T	TA	Duplication	Uncertain_significance	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RPS6KA3	chrX	20194577	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20194591	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20194593	C	A	single_nucleotide_variant	Likely_pathogenic	Mental_retardation,_X-linked_19	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20194696	CTAAT	C	Microsatellite	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20194771	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20194832	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20195116	A	C	single_nucleotide_variant	Pathogenic	Coffin-Lowry_syndrome	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20195125	G	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20195135	G	A	single_nucleotide_variant	Pathogenic	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20195145	CATTCGTAAA	C	Deletion	Uncertain_significance	Coffin-Lowry_syndrome	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
RPS6KA3	chrX	20195150	G	A	single_nucleotide_variant	Pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20195158	C	T	single_nucleotide_variant	Uncertain_significance	Inborn_genetic_diseases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20195208	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20195268	CTTAAA	C	Microsatellite	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20204187	ACT	A	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20204193	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20204306	T	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20204442	G	A	single_nucleotide_variant	Pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20204444	TC	T	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS6KA3	chrX	20204456	A	G	single_nucleotide_variant	Pathogenic	Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20204461	G	T	single_nucleotide_variant	Benign	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome\|History_of_neurodevelopmental_disorder\|not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20204548	TA	T	Deletion	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20204668	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20204678	G	GT	Duplication	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20204718	A	AT	Duplication	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20205640	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20205856	A	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20205918	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20205945	C	G	single_nucleotide_variant	Likely_pathogenic	Coffin-Lowry_syndrome	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RPS6KA3	chrX	20205945	C	T	single_nucleotide_variant	Pathogenic	Inborn_genetic_diseases	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RPS6KA3	chrX	20205956	C	T	single_nucleotide_variant	Uncertain_significance	Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20205966	A	G	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20205972	C	T	single_nucleotide_variant	Likely_pathogenic	Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20205993	G	A	single_nucleotide_variant	Pathogenic	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20205998	TTAAC	T	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS6KA3	chrX	20206002	C	T	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20206008	C	A	single_nucleotide_variant	Pathogenic	Inborn_genetic_diseases	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20206013	G	A	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20206041	A	C	single_nucleotide_variant	Pathogenic	Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20206070	TCTTTA	T	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS6KA3	chrX	20206071	C	T	single_nucleotide_variant	Likely_pathogenic	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20206074	T	C	single_nucleotide_variant	Likely_pathogenic	Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20206088	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20206089	C	G	single_nucleotide_variant	Pathogenic	Coffin-Lowry_syndrome\|not_provided	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
RPS6KA3	chrX	20206089	C	T	single_nucleotide_variant	Pathogenic	not_provided	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
RPS6KA3	chrX	20206091	G	A	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20206095	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20206284	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20206336	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20206608	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20206617	G	A	single_nucleotide_variant	Likely_pathogenic	Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20206629	T	C	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20206632	CCTT	C	Microsatellite	Likely_pathogenic	not_provided	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
RPS6KA3	chrX	20206637	TTCA	T	Microsatellite	Pathogenic	not_provided	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
RPS6KA3	chrX	20206655	G	GA	Duplication	Benign/Likely_benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20211273	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20211599	CCTTA	C	Deletion	Pathogenic	not_provided	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RPS6KA3	chrX	20211632	A	T	single_nucleotide_variant	Pathogenic	Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20211665	G	C	single_nucleotide_variant	Likely_pathogenic	Micrognathia\|Low_anterior_hairline\|Deep_philtrum\|Hypertelorism\|Triangular_face\|Low-set_ears\|Specific_learning_disability\|Ventricular_septal_defect\|Mitral_valve_prolapse\|Gastroesophageal_reflux\|Low_posterior_hairline\|Abnormality_of_the_lower_limb\|Thoracolu	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20211686	T	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20212304	T	C	single_nucleotide_variant	Pathogenic	Coffin-Lowry_syndrome	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20212307	C	T	single_nucleotide_variant	Pathogenic	Inborn_genetic_diseases	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20212321	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20212332	TCTC	T	Microsatellite	Pathogenic	Mental_retardation,_X-linked_19	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
RPS6KA3	chrX	20212340	CCT	C	Deletion	Pathogenic	Coffin-Lowry_syndrome	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS6KA3	chrX	20212350	T	A	single_nucleotide_variant	Likely_pathogenic	Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20212350	TC	T	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS6KA3	chrX	20212361	A	C	single_nucleotide_variant	Pathogenic	Coffin-Lowry_syndrome	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20212390	A	C	single_nucleotide_variant	Uncertain_significance	Hirsutism\|Motor_delay	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20213230	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20213233	C	G	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20213246	T	A	single_nucleotide_variant	Pathogenic	Mental_retardation,_X-linked_19	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20213249	G	A	single_nucleotide_variant	Likely_pathogenic	Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20213255	G	A	single_nucleotide_variant	Pathogenic	Coffin-Lowry_syndrome	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20213261	G	A	single_nucleotide_variant	Pathogenic	Intellectual_disability\|Coffin-Lowry_syndrome\|not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20213261	GA	G	Deletion	Pathogenic	Coffin-Lowry_syndrome	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS6KA3	chrX	20213264	C	G	single_nucleotide_variant	Pathogenic	Coffin-Lowry_syndrome	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
RPS6KA3	chrX	20213274	T	C	single_nucleotide_variant	Likely_pathogenic	Coffin-Lowry_syndrome\|Inborn_genetic_diseases	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20213278	A	AT	Duplication	Uncertain_significance	Mental_retardation,_X-linked_19	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20213607	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20221943	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20222167	T	A	single_nucleotide_variant	Likely_pathogenic	See_cases	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20222170	T	C	single_nucleotide_variant	Uncertain_significance	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20222180	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20222204	T	G	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20222213	TA	T	Deletion	Pathogenic	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20222221	C	A	single_nucleotide_variant	Pathogenic	Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20222226	A	G	single_nucleotide_variant	Benign/Likely_benign	History_of_neurodevelopmental_disorder\|not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20222422	T	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20222485	C	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20227405	C	T	single_nucleotide_variant	Pathogenic	Coffin-Lowry_syndrome	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RPS6KA3	chrX	20227406	C	G	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20227424	C	A	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20227425	C	A	single_nucleotide_variant	Pathogenic	Coffin-Lowry_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20227436	T	C	single_nucleotide_variant	Benign	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome\|History_of_neurodevelopmental_disorder\|not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20227437	A	C	single_nucleotide_variant	Likely_pathogenic	Coffin-Lowry_syndrome	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20227444	C	A	single_nucleotide_variant	Pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS6KA3	chrX	20227445	A	C	single_nucleotide_variant	Pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20227463	CT	C	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS6KA3	chrX	20227484	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS6KA3	chrX	20227510	T	C	single_nucleotide_variant	Benign/Likely_benign	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome\|not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20227512	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20227745	GTTA	G	Microsatellite	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KA3	chrX	20252880	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20252889	A	C	single_nucleotide_variant	Benign	Mental_retardation,_X-linked_19\|Coffin-Lowry_syndrome\|History_of_neurodevelopmental_disorder\|not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20284689	C	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20284703	C	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS6KA3	chrX	20284862	GGCGGCA	G	Microsatellite	Benign	not_provided	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS6KA3	KIRP	chrX	20195138	20195138	T	C	Missense_Mutation	p.K304E	4
RPS6KA3	UCEC	chrX	20204442	20204442	G	A	Nonsense_Mutation	p.R273*	4
RPS6KA3	BRCA	chrX	20213261	20213261	G	A	Nonsense_Mutation	p.R110*	4
RPS6KA3	UCEC	chrX	20212320	20212320	C	T	Missense_Mutation	p.R158H	3
RPS6KA3	READ	chrX	20185793	20185793	G	T	Missense_Mutation	p.L506I	3
RPS6KA3	LIHC	chrX	20181160	20181160	T	A	Splice_Site		3
RPS6KA3	LIHC	chrX	20194571	20194571	A	-	Frame_Shift_Del	p.F327fs	3
RPS6KA3	BRCA	chrX	20185730	20185730	C	T	Missense_Mutation	p.V527I	3
RPS6KA3	BRCA	chrX	20195139	20195139	G	C	Missense_Mutation	p.F303L	3
RPS6KA3	UCEC	chrX	20183054	20183054	A	G	Missense_Mutation	p.M576T	3
RPS6KA3	CESC	chrX	20179862	20179862	T	A	Missense_Mutation		2
RPS6KA3	LIHC	chrX	20252926	20252926	G	A	Nonsense_Mutation	p.Q26X	2
RPS6KA3	UCEC	chrX	20194405	20194405	G	T	Missense_Mutation	p.F355L	2
RPS6KA3	KIRP	chrX	20194424	20194424	C	T	Missense_Mutation	p.G349D	2
RPS6KA3	LIHC	chrX	20194413	20194413	C	A	Missense_Mutation		2
RPS6KA3	UCEC	chrX	20194574	20194574	A	G	Missense_Mutation	p.F326S	2
RPS6KA3	LIHC	chrX	20252926	20252926	G	A	Nonsense_Mutation	p.Q26*	2
RPS6KA3	UCEC	chrX	20204433	20204433	T	C	Missense_Mutation	p.T276A	2
RPS6KA3	LIHC	chrX	20252926	20252926	G	A	Nonsense_Mutation		2
RPS6KA3	STAD	chrX	20252924	20252924	C	A	Missense_Mutation		2
RPS6KA3	UCEC	chrX	20173604	20173604	C	T	Missense_Mutation	p.R712H	2
RPS6KA3	LIHC	chrX	20227476	20227476	T	A	Missense_Mutation		2
RPS6KA3	UCEC	chrX	20179807	20179807	G	T	Missense_Mutation	p.F638L	2
RPS6KA3	BRCA	chrX	20212321	20212321	G	A	Missense_Mutation	p.R158C	2
RPS6KA3	CHOL	chrX	20183169	20183169	T	C	Missense_Mutation		2
RPS6KA3	LIHC	chrX	20227476	20227476	T	A	Missense_Mutation	p.E58V	2
RPS6KA3	UCEC	chrX	20213226	20213226	G	T	Silent	p.I121	2
RPS6KA3	STAD	chrX	20252924	20252924	C	A	Missense_Mutation	p.Q26H	2
RPS6KA3	HNSC	chrX	20211697	20211697	T	A	Missense_Mutation	p.E167D	2
RPS6KA3	LUAD	chrX	20195194	20195194	A	G	Missense_Mutation	p.L285P	2
RPS6KA3	UCEC	chrX	20179840	20179840	C	A	Missense_Mutation	p.E627D	2
RPS6KA3	LGG	chrX	20227405	20227405	C	A	Splice_Site		2
RPS6KA3	CHOL	chrX	20183169	20183169	T	C	Missense_Mutation	p.R538G	2
RPS6KA3	UCEC	chrX	20222141	20222141	T	-	Frame_Shift_Del	p.V109fs	2
RPS6KA3	STAD	chrX	20190977	20190977	T	C	Missense_Mutation	p.N414D	2
RPS6KA3	BLCA	chrX	20194392	20194392	C	G	Missense_Mutation	p.E360Q	2
RPS6KA3	HNSC	chrX	20190890	20190890	C	T	Missense_Mutation	p.A443T	2
RPS6KA3	LIHC	chrX	20252920	20252920	T	-	Frame_Shift_Del	p.I28fs	2
RPS6KA3	SKCM	chrX	20206023	20206023	C	T	Missense_Mutation	p.E233K	2
RPS6KA3	LIHC	chrX	20181109	20181109	C	T	Missense_Mutation		2
RPS6KA3	UCEC	chrX	20185715	20185715	C	T	Missense_Mutation	p.A532T	2
RPS6KA3	CHOL	chrX	20179855	20179855	A	G	Silent	p.P622P	2
RPS6KA3	UCEC	chrX	20222222	20222222	C	T	Splice_Site	e4-1	2
RPS6KA3	STAD	chrX	20173605	20173605	G	A	Missense_Mutation	p.R712C	2
RPS6KA3	LIHC	chrX	20206011	20206011	G	A	Missense_Mutation		2
RPS6KA3	UCEC	chrX	20185716	20185716	G	A	Silent	p.H531	2
RPS6KA3	UCEC	chrX	20227435	20227435	T	G	Missense_Mutation	p.K72Q	2
RPS6KA3	SKCM	chrX	20252888	20252888	A	G	Silent	p.I38I	2
RPS6KA3	STAD	chrX	20195149	20195149	C	T	Missense_Mutation	p.R300Q	2
RPS6KA3	HNSC	chrX	20195158	20195159	CT	-	Frame_Shift_Del	p.S297fs	2
RPS6KA3	LUAD	chrX	20181107	20181107	C	T	Missense_Mutation	p.V606I	2
RPS6KA3	UCEC	chrX	20185779	20185779	A	C	Missense_Mutation	p.F510L	2
RPS6KA3	UCS	chrX	20185863	20185863	T	C	Silent	p.V482V	2
RPS6KA3	LIHC	chrX	20206011	20206011	G	A	Missense_Mutation	p.P237S	2
RPS6KA3	SKCM	chrX	20211670	20211670	T	C	Silent	p.E176E	2
RPS6KA3	STAD	chrX	20205970	20205970	G	A	Silent	p.D250D	2
RPS6KA3	BLCA	chrX	20205975	20205975	C	T	Missense_Mutation	p.A249T	2
RPS6KA3	CESC	chrX	20185772	20185772	C	T	Missense_Mutation		2
RPS6KA3	LGG	chrX	20205954	20205954	C	A	Missense_Mutation		2
RPS6KA3	LUAD	chrX	20187547	20187547	C	G	Missense_Mutation	p.Q472H	2
RPS6KA3	UCEC	chrX	20187558	20187558	G	A	Missense_Mutation	p.R469C	2
RPS6KA3	SKCM	chrX	20174290	20174290	G	A	Silent	p.I679I	2
RPS6KA3	LUAD	chrX	20212340	20212340	C	A	Missense_Mutation	p.R151S	2
RPS6KA3	UCEC	chrX	20193391	20193391	G	T	Missense_Mutation	p.P373Q	2
RPS6KA3	LIHC	chrX	20227433	20227433	T	-	Frame_Shift_Del	p.K72fs	1
RPS6KA3	SKCM	chrX	20187579	20187579	C	T	Missense_Mutation	p.E462K	1
RPS6KA3	BLCA	chrX	20236925	20236925	G	C	Missense_Mutation	p.S11C	1
RPS6KA3	LGG	chrX	20190905	20190905	T	C	Missense_Mutation		1
RPS6KA3	LUAD	chrX	20222213	20222213	T	C	Silent	p.L84L	1
RPS6KA3	BLCA	chrX	20236925	20236925	G	C	Missense_Mutation		1
RPS6KA3	GBM	chrX	20194421	20194421	C	A	Missense_Mutation		1
RPS6KA3	LIHC	chrX	20194413	20194413	C	A	Missense_Mutation	p.D353Y	1
RPS6KA3	LIHC	chrX	20187591	20187591	T	A	Nonsense_Mutation		1
RPS6KA3	SKCM	chrX	20212370	20212370	C	T	Silent	p.G141G	1
RPS6KA3	UCEC	chrX	20183071	20183071	C	T	Silent	p.A570A	1
RPS6KA3	BLCA	chrX	20195168	20195168	C	T	Missense_Mutation	p.E294K	1
RPS6KA3	CESC	chrX	20181158	20181158	C	A	Missense_Mutation		1
RPS6KA3	LIHC	chrX	20222202	20222203	-	T	Frame_Shift_Ins	p.I88fs	1
RPS6KA3	LUSC	chrX	20194426	20194426	C	A	Silent	p.T348T	1
RPS6KA3	BLCA	chrX	20190959	20190959	C	T	Missense_Mutation		1
RPS6KA3	GBM	chrX	20193367	20193367	A	T	Missense_Mutation		1
RPS6KA3	SARC	chrX	20187595	20187595	G	T	Missense_Mutation		1
RPS6KA3	LIHC	chrX	20190902	20190902	A	G	Missense_Mutation		1
RPS6KA3	SKCM	chrX	20212314	20212314	G	A	Missense_Mutation	p.S160F	1
RPS6KA3	UCEC	chrX	20222141	20222141	T	-	Frame_Shift_Del	p.V109_splice	1
RPS6KA3	BLCA	chrX	20212356	20212356	A	G	Missense_Mutation	p.I146T	1
RPS6KA3	KIRP	chrX	20206637	20206637	T	C	Silent	p.E203E	1
RPS6KA3	CESC	chrX	20179862	20179862	T	A	Missense_Mutation	p.N620I	1
RPS6KA3	LIHC	chrX	20227465	20227465	T	C	Missense_Mutation		1
RPS6KA3	LIHC	chrX	20187600	20187600	T	A	Nonsense_Mutation	p.K455X	1
RPS6KA3	LUSC	chrX	20195156	20195156	G	A	Missense_Mutation	p.L298F	1
RPS6KA3	BLCA	chrX	20174206	20174228	TGACTGTATGGGGCTGCTCACCT	-	Splice_Site		1
RPS6KA3	HNSC	chrX	20195158	20195159	CT	-	Frame_Shift_Del		1
RPS6KA3	LIHC	chrX	20181109	20181109	C	T	Missense_Mutation	p.G605D	1
RPS6KA3	SARC	chrX	20236927	20236927	G	T	Silent		1
RPS6KA3	BLCA	chrX	20174206	20174228	TGACTGTATGGGGCTGCTCACCT	-	Splice_Site	p.KV700fs	1
RPS6KA3	KIRP	chrX	20222171	20222171	G	A	Silent	p.A98A	1
RPS6KA3	CESC	chrX	20185772	20185772	C	T	Missense_Mutation	p.E513K	1
RPS6KA3	LIHC	chrX	20179839	20179839	C	A	Nonsense_Mutation	p.E628X	1
RPS6KA3	MESO	chrX	20173628	20173628	G	T	Missense_Mutation		1
RPS6KA3	BLCA	chrX	20195168	20195168	C	T	Missense_Mutation		1
RPS6KA3	HNSC	chrX	20211697	20211697	T	A	Missense_Mutation		1
RPS6KA3	LIHC	chrX	20181148	20181149	-	T	Frame_Shift_Ins	p.T592fs	1
RPS6KA3	SARC	chrX	20185756	20185756	G	T	Missense_Mutation		1
RPS6KA3	LUAD	chrX	20173624	20173624	A	T	Silent	p.A705A	1
RPS6KA3	KIRP	chrX	20194424	20194424	C	T	Missense_Mutation		1
RPS6KA3	OV	chrX	20194459	20194459	T	C	Silent	p.R337R	1
RPS6KA3	BLCA	chrX	20212356	20212356	A	G	Missense_Mutation		1
RPS6KA3	SARC	chrX	20236927	20236927	G	T	Silent	p.R10R	1
RPS6KA3	LIHC	chrX	20211662	20211662	A	C	Missense_Mutation	p.L179R	1
RPS6KA3	OV	chrX	20095754	20095754	T	C	Silent	p.V492	1
RPS6KA3	LUAD	chrX	20185764	20185764	C	A	Missense_Mutation	p.E515D	1
RPS6KA3	LGG	chrX	20205954	20205954	C	A	Missense_Mutation	p.V256L	1
RPS6KA3	LIHC	chrX	20187519	20187519	C	T	Splice_Site	.	1
RPS6KA3	PRAD	chrX	20190906	20190906	C	T	Silent	p.K437K	1
RPS6KA3	LIHC	chrX	20194377	20194377	T	-	Frame_Shift_Del	p.T365fs	1
RPS6KA3	SKCM	chrX	20213260	20213260	C	T	Missense_Mutation	p.R110Q	1
RPS6KA3	BLCA	chrX	20252921	20252921	T	G	Missense_Mutation	p.Q27H	1
RPS6KA3	HNSC	chrX	20190989	20190989	G	A	Splice_Site	p.Q410_splice	1
RPS6KA3	LGG	chrX	20190905	20190905	T	C	Missense_Mutation	p.R438G	1
RPS6KA3	LUAD	chrX	20185763	20185763	C	A	Missense_Mutation	p.A516S	1
RPS6KA3	BLCA	chrX	20181083	20181083	C	A	Missense_Mutation		1
RPS6KA3	COAD	chrX	20194555	20194555	C	A	Missense_Mutation	p.W332C	1
RPS6KA3	LIHC	chrX	20181160	20181160	T	A	Splice_Site	.	1
RPS6KA3	PRAD	chrX	20222195	20222195	G	T	Silent	p.G90G	1
RPS6KA3	LIHC	chrX	20236948	20236948	T	-	Frame_Shift_Del	p.K3fs	1
RPS6KA3	BLCA	chrX	20190950	20190950	C	A	Nonsense_Mutation	p.E423*	1
RPS6KA3	CESC	chrX	20204461	20204461	G	T	Silent		1
RPS6KA3	LGG	chrX	20185731	20185731	G	A	Silent	p.T526T	1
RPS6KA3	LIHC	chrX	20227475	20227475	T	C	Silent		1
RPS6KA3	BLCA	chrX	20194392	20194392	C	G	Missense_Mutation		1
RPS6KA3	COAD	chrX	20204461	20204461	G	T	Silent	p.L266L	1
RPS6KA3	PRAD	chrX	20185708	20185708	C	A	Splice_Site	p.G534V	1
RPS6KA3	LIHC	chrX	20195166	20195166	T	-	Frame_Shift_Del	p.E294fs	1
RPS6KA3	KICH	chrX	20187576	20187576	C	T	Missense_Mutation	p.E463K	1
RPS6KA3	LIHC	chrX	20206619	20206619	T	A	Missense_Mutation	p.L209F	1
RPS6KA3	BLCA	chrX	20252921	20252921	T	G	Missense_Mutation		1
RPS6KA3	GBM	chrX	20193367	20193367	A	T	Missense_Mutation	p.L381H	1
RPS6KA3	LIHC	chrX	20183141	20183141	T	C	Missense_Mutation	p.Y547C	1
RPS6KA3	READ	chrX	20185776	20185776	G	T	Missense_Mutation	p.F511L	1
RPS6KA3	LIHC	chrX	20206035	20206035	A	-	Frame_Shift_Del	p.C229fs	1
RPS6KA3	BLCA	chrX	20183019	20183019	C	T	Missense_Mutation	p.E588K	1
RPS6KA3	KIRC	chrX	20185788	20185788	T	A	Missense_Mutation	p.R507S	1
RPS6KA3	CESC	chrX	20194605	20194605	C	G	Missense_Mutation		1
RPS6KA3	LGG	chrX	20185731	20185731	G	A	Silent		1
RPS6KA3	LIHC	chrX	20185787	20185787	G	C	Missense_Mutation	p.Q508E	1
RPS6KA3	BLCA	chrX	20205975	20205975	C	T	Missense_Mutation		1
RPS6KA3	GBM	chrX	20194610	20194610	C	T	Missense_Mutation		1
RPS6KA3	LIHC	chrX	20213230	20213230	T	C	Missense_Mutation	p.D120G	1
RPS6KA3	READ	chrX	20227509	20227509	A	C	Missense_Mutation	p.I47S	1

Copy number variation (CNV) of RPS6KA3
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS6KA3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101120	N/A	CA843287	ACTR3	chr2	114715521	-	RPS6KA3	chrX	20171470	+
101120	N/A	AW006813	ANXA9	chr1	150965882	+	RPS6KA3	chrX	19925300	+
101120	Non-Cancer	ERR315461	EIF1AX	chrX	20153856	-	RPS6KA3	chrX	20181158	-
101120	N/A	DA592743	ITGA4	chr2	182323044	+	RPS6KA3	chrX	20252933	-
101120	SARC	TCGA-DX-A3UC-01A	KDM6A	chrX	44950109	-	RPS6KA3	chrX	20252932	-
103286	N/A	CA843526	RPS6KA3	chrX	20171470	-	ACTR3	chr2	114715521	+
88753	STAD	TCGA-EQ-8122-01A	RPS6KA3	chrX	20284682	-	AUH	chr9	94060358	-
78012	STAD	TCGA-CD-8527-01A	RPS6KA3	chrX	20284682	-	BMX	chrX	15526468	+
78012	STAD	TCGA-CD-8527-01A	RPS6KA3	chrX	20285157	-	BMX	chrX	15526468	+
95449	N/A	EC561147	RPS6KA3	chrX	20202495	+	C12orf57	chr12	7053240	+
78012	LIHC	TCGA-DD-AADJ	RPS6KA3	chrX	20284681	-	EIF1AX	chrX	20153959	-
78012	LIHC	TCGA-DD-AADJ-01A	RPS6KA3	chrX	20284682	-	EIF1AX	chrX	20153959	-
88029	LIHC	TCGA-DD-AADJ	RPS6KA3	chrX	20284681	-	EIF1AY	chrY	22744475	+
102436	LUSC	TCGA-NK-A5D1	RPS6KA3	chrX	20284682	-	FAM156A	chrX	52985953	-
78012	LUSC	TCGA-NK-A5D1-01A	RPS6KA3	chrX	20284682	-	FAM156B	chrX	52928085	+
102716	N/A	EC459803	RPS6KA3	chrX	20192580	-	IMMP2L	chr7	110922936	-
97776	SARC	TCGA-DX-A3UC	RPS6KA3	chrX	20284681	-	KDM6A	chrX	44966654	+
97776	SARC	TCGA-DX-A3UC-01A	RPS6KA3	chrX	20258687	-	KDM6A	chrX	44966655	+
97776	SARC	TCGA-DX-A3UC-01A	RPS6KA3	chrX	20284682	-	KDM6A	chrX	44966655	+
97776	SARC	TCGA-DX-A3UC-01A	RPS6KA3	chrX	20285157	-	KDM6A	chrX	44966655	+
81494	CESC	TCGA-EA-A411	RPS6KA3	chrX	20284681	-	MAP7D2	chrX	20082923	-
81494	CESC	TCGA-EA-A411-01A	RPS6KA3	chrX	20284682	-	MAP7D2	chrX	20082923	-
81494	LIHC	TCGA-CC-A123	RPS6KA3	chrX	20284681	-	MAP7D2	chrX	20044070	-
81494	LIHC	TCGA-CC-A123	RPS6KA3	chrX	20284682	-	MAP7D2	chrX	20044070	-
81494	SARC	TCGA-X6-A8C6-01A	RPS6KA3	chrX	20252876	-	MAP7D2	chrX	20074909	-
78012	ESCA	TCGA-IG-A97I	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
91290	LIHC	TCGA-DD-AACA-02A	RPS6KA3	chrX	20193282	-	PISD	chr22	32028277	-
78012	N/A	AJ012498	RPS6KA3	chrX	20189615	-	PRPH2	chr6	42674739	-
95294	STAD	TCGA-D7-8574-01A	RPS6KA3	chrX	20252876	-	SH3KBP1	chrX	19663593	-
101120	UCEC	TCGA-AJ-A3QS-01A	SH3KBP1	chrX	19854243	-	RPS6KA3	chrX	20227522	-
101120	STAD	TCGA-HU-A4HB-01A	SLC6A14	chrX	115582835	+	RPS6KA3	chrX	20183178	-
101120	STAD	TCGA-IN-7808-01A	YBX3	chr12	10865810	-	RPS6KA3	chrX	20252932	-
101120	STAD	TCGA-BR-A4QI-01A	ZDHHC9	chrX	128957655	-	RPS6KA3	chrX	20252932	-
101127	N/A	BG487432	ZFPM2	chr8	105822670	+	RPS6KA3	chrX	20168304	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	RPS6KA3	0.00767183862903574	0.21
KIRP	RPS6KA3	0.00794020749536366	0.21
THYM	RPS6KA3	0.0283266933369139	0.74
BRCA	RPS6KA3	0.0477666002802932	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	RPS6KA3	0.0226747428859788	0.66
KIRP	RPS6KA3	0.0023391505635219	0.073
BRCA	RPS6KA3	5.14197834652415e-06	0.00017
SKCM	RPS6KA3	0.00587517710164222	0.18
OV	RPS6KA3	9.782893280374e-06	0.00031

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P51812	DB00945	Acetylsalicylic acid	Inhibitor	Small molecule	Approved\|Vet_approved
P51812	DB12010	Fostamatinib	Inhibitor	Small molecule	Approved\|Investigational
P51812	DB00945	Acetylsalicylic acid	Inhibitor
P51812	DB12010	Fostamatinib	Inhibitor

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0265252	Coffin-Lowry syndrome	15	CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
C0796225	Mental Retardation, X-Linked 19	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
C2239176	Liver carcinoma	1	CTD_human
C2931498	Mental Retardation, X-Linked 1	1	ORPHANET