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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS6KB1 (NCBI Gene ID:6198)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS6KB1
	Gene ID: 6198
	Gene Symbol	RPS6KB1
	Gene ID	6198
	Gene Name	ribosomal protein S6 kinase B1
	Synonyms	PS6K\|S6K\|S6K-beta-1\|S6K1\|STK14A\|p70 S6KA\|p70(S6K)-alpha\|p70-S6K\|p70-alpha
	Cytomap	17q23.1
	Type of Gene	protein-coding
	Description	ribosomal protein S6 kinase beta-1p70 S6 kinase, alpharibosomal protein S6 kinase Iribosomal protein S6 kinase, 70kDa, polypeptide 1serine/threonine kinase 14 alphaserine/threonine-protein kinase 14A
	Modification date	20200313
	UniProtAcc	P23443

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS6KB1	GO:0031667	response to nutrient levels	29750193
Hgene	RPS6KB1	GO:0031929	TOR signaling	12150926
Hgene	RPS6KB1	GO:0071363	cellular response to growth factor stimulus	17936702

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS6KB1	(67.6 - 355.7]

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Translation Studies in PubMed

We searched PubMed using 'RPS6KB1[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS6KB1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000225577	57987922	57987972	Frame-shift
ENST00000225577	57991995	57992064	In-frame
ENST00000225577	58003795	58003943	Frame-shift
ENST00000225577	58008982	58009083	Frame-shift
ENST00000225577	58012553	58012661	In-frame
ENST00000225577	58013575	58013638	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000225577	57991995	57992064	5392	334	402	525	104	127
ENST00000225577	58012553	58012661	5392	892	999	525	290	326
ENST00000225577	58013575	58013638	5392	1000	1062	525	326	347

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P23443	104	127	1	525	Chain	ID=PRO_0000024342;Note=Ribosomal protein S6 kinase beta-1
P23443	290	326	1	525	Chain	ID=PRO_0000024342;Note=Ribosomal protein S6 kinase beta-1
P23443	326	347	1	525	Chain	ID=PRO_0000024342;Note=Ribosomal protein S6 kinase beta-1
P23443	104	127	91	352	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P23443	290	326	91	352	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P23443	326	347	91	352	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P23443	104	127	97	105	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P23443	104	127	123	123	Binding site	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P23443	104	127	104	126	Alternative sequence	ID=VSP_055026;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
P23443	104	127	101	110	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WF7
P23443	104	127	114	117	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WF7
P23443	104	127	119	126	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WF7
P23443	104	127	127	132	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WF7
P23443	290	326	298	307	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WF7
P23443	290	326	314	316	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3A61
P23443	290	326	318	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WF7
P23443	326	347	318	327	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WF7
P23443	326	347	332	334	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WF7
P23443	326	347	340	342	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WF7
P23443	326	347	343	347	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3WF7

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
PRAD	RPS6KB1	1.25047501981198	0.000199084406212897
COAD	RPS6KB1	-1.1133069567678	0.00144392251968384
HNSC	RPS6KB1	-1.27996809705029	0.0301271170746986
KIRP	RPS6KB1	-1.46465474284348	2.00420618057251e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
CESC	RPS6KB1	hsa-miR-455-5p	91	-0.329556519429937	0.00335856006534889
GBM	RPS6KB1	hsa-miR-429	88	-1	0.0166666666666667

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LGG	RPS6KB1	-0.167763283	0.000882997
UVM	RPS6KB1	0.261506755	0.016247322

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS6KB1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	RPS6KB1	PIP5K1A	0.801436735	7.77E-12
DLBC	Cell metabolism gene	RPS6KB1	AP3M1	0.803435705	6.30E-12
DLBC	Cell metabolism gene	RPS6KB1	POLR1B	0.804482938	5.64E-12
DLBC	Cell metabolism gene	RPS6KB1	SEC31A	0.804636933	5.55E-12
DLBC	Cell metabolism gene	RPS6KB1	EP300	0.812785368	2.29E-12
DLBC	Cell metabolism gene	RPS6KB1	SMG1	0.814730146	1.84E-12
DLBC	CGC	RPS6KB1	ARID2	0.80006023	8.96E-12
DLBC	CGC	RPS6KB1	SUZ12	0.800744078	8.35E-12
DLBC	CGC	RPS6KB1	BIRC6	0.804024279	5.92E-12
DLBC	CGC	RPS6KB1	ATF1	0.804811819	5.45E-12
DLBC	CGC	RPS6KB1	KRAS	0.809721329	3.21E-12
DLBC	CGC	RPS6KB1	EP300	0.812785368	2.29E-12
DLBC	CGC	RPS6KB1	CDK12	0.822326086	7.67E-13
DLBC	CGC	RPS6KB1	PTPN11	0.85080364	1.91E-14
DLBC	Epifactor	RPS6KB1	ARID2	0.80006023	8.96E-12
DLBC	Epifactor	RPS6KB1	SUZ12	0.800744078	8.35E-12
DLBC	Epifactor	RPS6KB1	SETD5	0.801211976	7.95E-12
DLBC	Epifactor	RPS6KB1	CHD1	0.803582411	6.20E-12
DLBC	Epifactor	RPS6KB1	SMARCAD1	0.804256413	5.78E-12
DLBC	Epifactor	RPS6KB1	EP300	0.812785368	2.29E-12
DLBC	Epifactor	RPS6KB1	GLYR1	0.836023965	1.42E-13
DLBC	Epifactor	RPS6KB1	ADNP	0.836208525	1.38E-13
DLBC	IUPHAR	RPS6KB1	TRPM7	0.801183557	7.98E-12
DLBC	IUPHAR	RPS6KB1	PIP5K1A	0.801436735	7.77E-12
DLBC	IUPHAR	RPS6KB1	BIRC6	0.804024279	5.92E-12
DLBC	IUPHAR	RPS6KB1	TNKS2	0.804323486	5.74E-12
DLBC	IUPHAR	RPS6KB1	KRAS	0.809721329	3.21E-12
DLBC	IUPHAR	RPS6KB1	EP300	0.812785368	2.29E-12
DLBC	IUPHAR	RPS6KB1	SMG1	0.814730146	1.84E-12
DLBC	IUPHAR	RPS6KB1	CDK12	0.822326086	7.67E-13
DLBC	IUPHAR	RPS6KB1	ATP2A2	0.835397097	1.54E-13
DLBC	Kinase	RPS6KB1	TRPM7	0.801183557	7.98E-12
DLBC	Kinase	RPS6KB1	SMG1	0.814730146	1.84E-12
DLBC	Kinase	RPS6KB1	CDK12	0.822326086	7.67E-13
DLBC	TF	RPS6KB1	ARID2	0.80006023	8.96E-12
DLBC	TF	RPS6KB1	ZNF776	0.801744319	7.52E-12
DLBC	TF	RPS6KB1	ATF1	0.804811819	5.45E-12
DLBC	TF	RPS6KB1	E2F3	0.807622129	4.03E-12
DLBC	TF	RPS6KB1	NFXL1	0.808900181	3.51E-12
DLBC	TF	RPS6KB1	ZNF567	0.809700229	3.22E-12
DLBC	TF	RPS6KB1	ATF7	0.811014045	2.78E-12
DLBC	TF	RPS6KB1	GLYR1	0.836023965	1.42E-13
DLBC	TF	RPS6KB1	ADNP	0.836208525	1.38E-13
DLBC	TF	RPS6KB1	ZBTB11	0.840136981	8.28E-14
DLBC	TF	RPS6KB1	ZNF644	0.846773235	3.37E-14
DLBC	TSG	RPS6KB1	ARID2	0.80006023	8.96E-12
DLBC	TSG	RPS6KB1	SUZ12	0.800744078	8.35E-12
DLBC	TSG	RPS6KB1	CHD1	0.803582411	6.20E-12
DLBC	TSG	RPS6KB1	E2F3	0.807622129	4.03E-12
DLBC	TSG	RPS6KB1	PTPN11	0.85080364	1.91E-14
SKCM	CGC	RPS6KB1	DDX5	0.816555231	1.05E-114
SKCM	Epifactor	RPS6KB1	TLK2	0.809171752	4.50E-111
SKCM	IUPHAR	RPS6KB1	TLK2	0.809171752	4.50E-111
SKCM	Kinase	RPS6KB1	TLK2	0.809171752	4.50E-111
SKCM	TF	RPS6KB1	LIN54	0.804197135	1.03E-108
SKCM	TF	RPS6KB1	VEZF1	0.805650238	2.14E-109
THYM	Cell metabolism gene	RPS6KB1	ARFGEF2	0.805847595	4.39E-29
THYM	Cell metabolism gene	RPS6KB1	AASDHPPT	0.815955343	2.45E-30
THYM	Cell metabolism gene	RPS6KB1	RANBP2	0.818071387	1.31E-30
THYM	Cell metabolism gene	RPS6KB1	ALG10B	0.848108176	6.72E-35
THYM	CGC	RPS6KB1	RANBP2	0.818071387	1.31E-30
THYM	Epifactor	RPS6KB1	AEBP2	0.802548917	1.09E-28
THYM	Epifactor	RPS6KB1	BPTF	0.811324685	9.40E-30
THYM	IUPHAR	RPS6KB1	SAMD8	0.807686613	2.63E-29
THYM	IUPHAR	RPS6KB1	PKN2	0.81052055	1.18E-29
THYM	IUPHAR	RPS6KB1	BPTF	0.811324685	9.40E-30
THYM	IUPHAR	RPS6KB1	SLC10A7	0.826164632	1.11E-31
THYM	IUPHAR	RPS6KB1	ATP13A3	0.840782065	9.01E-34
THYM	Kinase	RPS6KB1	PKN2	0.81052055	1.18E-29
THYM	TF	RPS6KB1	ZBTB11	0.800611457	1.83E-28
THYM	TF	RPS6KB1	AEBP2	0.802548917	1.09E-28
THYM	TF	RPS6KB1	NFXL1	0.807723329	2.61E-29
THYM	TF	RPS6KB1	BPTF	0.811324685	9.40E-30
UCS	Cell metabolism gene	RPS6KB1	ARFGEF2	0.805847595	4.39E-29
UCS	Cell metabolism gene	RPS6KB1	AASDHPPT	0.815955343	2.45E-30
UCS	Cell metabolism gene	RPS6KB1	RANBP2	0.818071387	1.31E-30
UCS	Cell metabolism gene	RPS6KB1	ALG10B	0.848108176	6.72E-35
UCS	CGC	RPS6KB1	RANBP2	0.818071387	1.31E-30
UCS	Epifactor	RPS6KB1	AEBP2	0.802548917	1.09E-28
UCS	Epifactor	RPS6KB1	BPTF	0.811324685	9.40E-30
UCS	IUPHAR	RPS6KB1	SAMD8	0.807686613	2.63E-29
UCS	IUPHAR	RPS6KB1	PKN2	0.81052055	1.18E-29
UCS	IUPHAR	RPS6KB1	BPTF	0.811324685	9.40E-30
UCS	IUPHAR	RPS6KB1	SLC10A7	0.826164632	1.11E-31
UCS	IUPHAR	RPS6KB1	ATP13A3	0.840782065	9.01E-34
UCS	Kinase	RPS6KB1	PKN2	0.81052055	1.18E-29
UCS	TF	RPS6KB1	ZBTB11	0.800611457	1.83E-28
UCS	TF	RPS6KB1	AEBP2	0.802548917	1.09E-28
UCS	TF	RPS6KB1	NFXL1	0.807723329	2.61E-29
UCS	TF	RPS6KB1	BPTF	0.811324685	9.40E-30
UVM	Cell metabolism gene	RPS6KB1	SUCLA2	0.801251021	4.46E-19
UVM	Cell metabolism gene	RPS6KB1	MINPP1	0.801907656	3.97E-19
UVM	Cell metabolism gene	RPS6KB1	MED21	0.803369263	3.06E-19
UVM	Cell metabolism gene	RPS6KB1	SRP19	0.803897668	2.79E-19
UVM	Cell metabolism gene	RPS6KB1	GPAM	0.80457599	2.47E-19
UVM	Cell metabolism gene	RPS6KB1	MTMR4	0.805295464	2.17E-19
UVM	Cell metabolism gene	RPS6KB1	MAN1A2	0.806367955	1.79E-19
UVM	Cell metabolism gene	RPS6KB1	HIF1A	0.807907721	1.35E-19
UVM	Cell metabolism gene	RPS6KB1	SLC19A2	0.808377772	1.24E-19
UVM	Cell metabolism gene	RPS6KB1	POLR3F	0.808397335	1.24E-19
UVM	Cell metabolism gene	RPS6KB1	GNAQ	0.809150061	1.08E-19
UVM	Cell metabolism gene	RPS6KB1	SRP72	0.809392523	1.03E-19
UVM	Cell metabolism gene	RPS6KB1	DCP2	0.809814999	9.53E-20
UVM	Cell metabolism gene	RPS6KB1	CCT2	0.812547182	5.73E-20
UVM	Cell metabolism gene	RPS6KB1	ACOX1	0.812815714	5.45E-20
UVM	Cell metabolism gene	RPS6KB1	IPMK	0.813472793	4.81E-20
UVM	Cell metabolism gene	RPS6KB1	CPOX	0.816850318	2.53E-20
UVM	Cell metabolism gene	RPS6KB1	SPTLC1	0.817303311	2.32E-20
UVM	Cell metabolism gene	RPS6KB1	VBP1	0.81755776	2.20E-20
UVM	Cell metabolism gene	RPS6KB1	PANK3	0.818597844	1.80E-20
UVM	Cell metabolism gene	RPS6KB1	MED7	0.820513216	1.24E-20
UVM	Cell metabolism gene	RPS6KB1	C1GALT1	0.820641434	1.21E-20
UVM	Cell metabolism gene	RPS6KB1	PIGA	0.821248716	1.07E-20
UVM	Cell metabolism gene	RPS6KB1	POLR2B	0.822676579	8.06E-21
UVM	Cell metabolism gene	RPS6KB1	ALG13	0.822917813	7.68E-21
UVM	Cell metabolism gene	RPS6KB1	PIP5K1A	0.823258965	7.17E-21
UVM	Cell metabolism gene	RPS6KB1	AGL	0.823335521	7.06E-21
UVM	Cell metabolism gene	RPS6KB1	SEH1L	0.824154399	5.99E-21
UVM	Cell metabolism gene	RPS6KB1	PIK3C3	0.827247019	3.19E-21
UVM	Cell metabolism gene	RPS6KB1	CSGALNACT2	0.827381312	3.11E-21
UVM	Cell metabolism gene	RPS6KB1	NFYB	0.82831865	2.56E-21
UVM	Cell metabolism gene	RPS6KB1	TRDMT1	0.829879573	1.85E-21
UVM	Cell metabolism gene	RPS6KB1	PIK3R1	0.830381754	1.66E-21
UVM	Cell metabolism gene	RPS6KB1	FBXW7	0.831095808	1.43E-21
UVM	Cell metabolism gene	RPS6KB1	TRMT11	0.831550958	1.30E-21
UVM	Cell metabolism gene	RPS6KB1	GLS	0.832138244	1.15E-21
UVM	Cell metabolism gene	RPS6KB1	NUP107	0.832755878	1.01E-21
UVM	Cell metabolism gene	RPS6KB1	PSMD14	0.832975883	9.62E-22
UVM	Cell metabolism gene	RPS6KB1	FPGT	0.832985072	9.60E-22
UVM	Cell metabolism gene	RPS6KB1	ACADSB	0.834000063	7.72E-22
UVM	Cell metabolism gene	RPS6KB1	EPT1	0.834061044	7.62E-22
UVM	Cell metabolism gene	RPS6KB1	HMGCS1	0.834780996	6.53E-22
UVM	Cell metabolism gene	RPS6KB1	LCLAT1	0.836558625	4.44E-22
UVM	Cell metabolism gene	RPS6KB1	UGP2	0.840270609	1.95E-22
UVM	Cell metabolism gene	RPS6KB1	NUP50	0.845989724	5.28E-23
UVM	Cell metabolism gene	RPS6KB1	L2HGDH	0.847454286	3.74E-23
UVM	Cell metabolism gene	RPS6KB1	BPNT1	0.851264625	1.51E-23
UVM	Cell metabolism gene	RPS6KB1	TBL1XR1	0.851293693	1.50E-23
UVM	Cell metabolism gene	RPS6KB1	ACSL4	0.852680873	1.07E-23
UVM	Cell metabolism gene	RPS6KB1	GPD2	0.853124626	9.57E-24
UVM	Cell metabolism gene	RPS6KB1	PPAT	0.854118761	7.49E-24
UVM	Cell metabolism gene	RPS6KB1	CNOT8	0.854598208	6.65E-24
UVM	Cell metabolism gene	RPS6KB1	DIS3	0.855686941	5.07E-24
UVM	Cell metabolism gene	RPS6KB1	IDI1	0.857790201	2.98E-24
UVM	Cell metabolism gene	RPS6KB1	UGGT2	0.860732748	1.40E-24
UVM	Cell metabolism gene	RPS6KB1	PIK3CA	0.862298769	9.28E-25
UVM	Cell metabolism gene	RPS6KB1	GRPEL2	0.86272847	8.28E-25
UVM	Cell metabolism gene	RPS6KB1	PLA2G12A	0.864306691	5.44E-25
UVM	Cell metabolism gene	RPS6KB1	SMG1	0.864355413	5.37E-25
UVM	Cell metabolism gene	RPS6KB1	PHAX	0.864519135	5.14E-25
UVM	Cell metabolism gene	RPS6KB1	COL4A3BP	0.865909733	3.54E-25
UVM	Cell metabolism gene	RPS6KB1	AASDHPPT	0.867708209	2.16E-25
UVM	Cell metabolism gene	RPS6KB1	TNPO1	0.868406238	1.78E-25
UVM	Cell metabolism gene	RPS6KB1	NUPL1	0.869996101	1.15E-25
UVM	Cell metabolism gene	RPS6KB1	NUDT12	0.871293439	7.95E-26
UVM	Cell metabolism gene	RPS6KB1	PPP1CB	0.871609919	7.27E-26
UVM	Cell metabolism gene	RPS6KB1	MTR	0.87364561	4.06E-26
UVM	Cell metabolism gene	RPS6KB1	SEC24B	0.874120164	3.54E-26
UVM	Cell metabolism gene	RPS6KB1	NUPL2	0.875299256	2.51E-26
UVM	Cell metabolism gene	RPS6KB1	CLOCK	0.875788731	2.17E-26
UVM	Cell metabolism gene	RPS6KB1	DCK	0.87722468	1.42E-26
UVM	Cell metabolism gene	RPS6KB1	DBT	0.877419673	1.34E-26
UVM	Cell metabolism gene	RPS6KB1	LPGAT1	0.878712611	9.09E-27
UVM	Cell metabolism gene	RPS6KB1	GXYLT1	0.879434302	7.30E-27
UVM	Cell metabolism gene	RPS6KB1	NAMPT	0.882012038	3.31E-27
UVM	Cell metabolism gene	RPS6KB1	ENOPH1	0.882502672	2.84E-27
UVM	Cell metabolism gene	RPS6KB1	MTMR6	0.882648003	2.71E-27
UVM	Cell metabolism gene	RPS6KB1	MED17	0.883738012	1.93E-27
UVM	Cell metabolism gene	RPS6KB1	ALG10B	0.883999676	1.77E-27
UVM	Cell metabolism gene	RPS6KB1	SACM1L	0.889742489	2.74E-28
UVM	Cell metabolism gene	RPS6KB1	NUP54	0.890804986	1.92E-28
UVM	Cell metabolism gene	RPS6KB1	GNPDA2	0.893828661	6.80E-29
UVM	Cell metabolism gene	RPS6KB1	AGPS	0.896019409	3.15E-29
UVM	Cell metabolism gene	RPS6KB1	MANEA	0.8960441	3.12E-29
UVM	Cell metabolism gene	RPS6KB1	RANBP2	0.897376073	1.94E-29
UVM	Cell metabolism gene	RPS6KB1	FAR1	0.898847566	1.13E-29
UVM	Cell metabolism gene	RPS6KB1	XPO1	0.899725947	8.21E-30
UVM	Cell metabolism gene	RPS6KB1	PRKAA1	0.899929089	7.62E-30
UVM	Cell metabolism gene	RPS6KB1	PSMC6	0.901891643	3.66E-30
UVM	Cell metabolism gene	RPS6KB1	PNPLA8	0.907441199	4.20E-31
UVM	Cell metabolism gene	RPS6KB1	PIKFYVE	0.912142588	6.03E-32
UVM	Cell metabolism gene	RPS6KB1	FBXL3	0.918259427	4.06E-33
UVM	Cell metabolism gene	RPS6KB1	ETNK1	0.919301599	2.51E-33
UVM	Cell metabolism gene	RPS6KB1	EDEM3	0.930051267	1.17E-35
UVM	CGC	RPS6KB1	MDM4	0.801268167	4.44E-19
UVM	CGC	RPS6KB1	ATR	0.804308976	2.59E-19
UVM	CGC	RPS6KB1	NFE2L2	0.80788343	1.36E-19
UVM	CGC	RPS6KB1	HIF1A	0.807907721	1.35E-19
UVM	CGC	RPS6KB1	GNAQ	0.809150061	1.08E-19
UVM	CGC	RPS6KB1	RAD21	0.809213789	1.06E-19
UVM	CGC	RPS6KB1	WRN	0.81057162	8.28E-20
UVM	CGC	RPS6KB1	SMARCE1	0.812779915	5.48E-20
UVM	CGC	RPS6KB1	DDX10	0.813655323	4.65E-20
UVM	CGC	RPS6KB1	RABEP1	0.813695143	4.61E-20
UVM	CGC	RPS6KB1	MAP2K4	0.816436863	2.74E-20
UVM	CGC	RPS6KB1	MAP3K1	0.817759295	2.12E-20
UVM	CGC	RPS6KB1	CDKN1B	0.819198056	1.60E-20
UVM	CGC	RPS6KB1	TRIP11	0.820091469	1.34E-20
UVM	CGC	RPS6KB1	IL6ST	0.820639547	1.21E-20
UVM	CGC	RPS6KB1	BIRC6	0.824055554	6.11E-21
UVM	CGC	RPS6KB1	HNRNPA2B1	0.824969601	5.08E-21
UVM	CGC	RPS6KB1	AKAP9	0.82570918	4.37E-21
UVM	CGC	RPS6KB1	GOLGA5	0.829211651	2.13E-21
UVM	CGC	RPS6KB1	PIK3R1	0.830381754	1.66E-21
UVM	CGC	RPS6KB1	FBXW7	0.831095808	1.43E-21
UVM	CGC	RPS6KB1	ZMYM2	0.832307059	1.11E-21
UVM	CGC	RPS6KB1	ACVR2A	0.834251689	7.32E-22
UVM	CGC	RPS6KB1	AFF4	0.834993111	6.23E-22
UVM	CGC	RPS6KB1	STAG1	0.838359485	2.99E-22
UVM	CGC	RPS6KB1	ATRX	0.838445884	2.93E-22
UVM	CGC	RPS6KB1	POT1	0.839687589	2.22E-22
UVM	CGC	RPS6KB1	RB1	0.839783155	2.18E-22
UVM	CGC	RPS6KB1	PALB2	0.841354531	1.53E-22
UVM	CGC	RPS6KB1	APC	0.844806355	6.95E-23
UVM	CGC	RPS6KB1	HSP90AA1	0.846464128	4.72E-23
UVM	CGC	RPS6KB1	FIP1L1	0.847523932	3.68E-23
UVM	CGC	RPS6KB1	N4BP2	0.847724773	3.51E-23
UVM	CGC	RPS6KB1	BAZ1A	0.849136377	2.51E-23
UVM	CGC	RPS6KB1	SPOP	0.850985847	1.61E-23
UVM	CGC	RPS6KB1	TBL1XR1	0.851293693	1.50E-23
UVM	CGC	RPS6KB1	TRIM33	0.853366653	9.01E-24
UVM	CGC	RPS6KB1	ATM	0.854724058	6.44E-24
UVM	CGC	RPS6KB1	ITGAV	0.854922684	6.13E-24
UVM	CGC	RPS6KB1	MLLT10	0.855376132	5.48E-24
UVM	CGC	RPS6KB1	GOPC	0.856210732	4.44E-24
UVM	CGC	RPS6KB1	ABI1	0.857299067	3.38E-24
UVM	CGC	RPS6KB1	ARID2	0.857653667	3.09E-24
UVM	CGC	RPS6KB1	ERCC4	0.857707238	3.04E-24
UVM	CGC	RPS6KB1	ATF1	0.858042967	2.79E-24
UVM	CGC	RPS6KB1	JAK2	0.859029388	2.17E-24
UVM	CGC	RPS6KB1	PWWP2A	0.859257251	2.05E-24
UVM	CGC	RPS6KB1	KTN1	0.860141086	1.63E-24
UVM	CGC	RPS6KB1	PIK3CA	0.862298769	9.28E-25
UVM	CGC	RPS6KB1	PHF6	0.863664933	6.46E-25
UVM	CGC	RPS6KB1	RAD17	0.86707245	2.58E-25
UVM	CGC	RPS6KB1	BMPR1A	0.871487943	7.53E-26
UVM	CGC	RPS6KB1	MSH2	0.872641725	5.42E-26
UVM	CGC	RPS6KB1	KRAS	0.874143026	3.51E-26
UVM	CGC	RPS6KB1	DEK	0.875629301	2.28E-26
UVM	CGC	RPS6KB1	MALT1	0.877353837	1.37E-26
UVM	CGC	RPS6KB1	USP8	0.877681508	1.24E-26
UVM	CGC	RPS6KB1	KIF5B	0.87954628	7.06E-27
UVM	CGC	RPS6KB1	SMAD4	0.88275169	2.63E-27
UVM	CGC	RPS6KB1	ARHGAP5	0.884419517	1.55E-27
UVM	CGC	RPS6KB1	BCLAF1	0.888202725	4.56E-28
UVM	CGC	RPS6KB1	DICER1	0.888556371	4.06E-28
UVM	CGC	RPS6KB1	TET2	0.888730623	3.83E-28
UVM	CGC	RPS6KB1	RGPD3	0.889173895	3.31E-28
UVM	CGC	RPS6KB1	RANBP2	0.897376073	1.94E-29
UVM	CGC	RPS6KB1	DDX5	0.899336353	9.48E-30
UVM	CGC	RPS6KB1	XPO1	0.899725947	8.21E-30
UVM	CGC	RPS6KB1	CUL3	0.904080797	1.58E-30
UVM	CGC	RPS6KB1	PMS1	0.911954022	6.53E-32
UVM	CGC	RPS6KB1	CDC73	0.912919359	4.33E-32
UVM	CGC	RPS6KB1	STAG2	0.91315032	3.92E-32
UVM	CGC	RPS6KB1	FBXO11	0.916069687	1.09E-32
UVM	CGC	RPS6KB1	ETNK1	0.919301599	2.51E-33
UVM	CGC	RPS6KB1	SF3B1	0.926484864	7.61E-35
UVM	CGC	RPS6KB1	SUZ12	0.93714705	2.07E-37
UVM	CGC	RPS6KB1	CREB1	0.941853728	1.09E-38
UVM	Epifactor	RPS6KB1	SETDB2	0.801709843	4.11E-19
UVM	Epifactor	RPS6KB1	UBR2	0.802411942	3.63E-19
UVM	Epifactor	RPS6KB1	DNAJC2	0.803682749	2.90E-19
UVM	Epifactor	RPS6KB1	MGA	0.803954162	2.76E-19
UVM	Epifactor	RPS6KB1	ATR	0.804308976	2.59E-19
UVM	Epifactor	RPS6KB1	SP100	0.8045273	2.49E-19
UVM	Epifactor	RPS6KB1	FAM175A	0.80656586	1.73E-19
UVM	Epifactor	RPS6KB1	MTF2	0.807626405	1.42E-19
UVM	Epifactor	RPS6KB1	TAF9B	0.808298744	1.26E-19
UVM	Epifactor	RPS6KB1	WAC	0.809157649	1.08E-19
UVM	Epifactor	RPS6KB1	ANKRD32	0.809183793	1.07E-19
UVM	Epifactor	RPS6KB1	ING3	0.811558703	6.89E-20
UVM	Epifactor	RPS6KB1	SMARCE1	0.812779915	5.48E-20
UVM	Epifactor	RPS6KB1	SHPRH	0.815530311	3.26E-20
UVM	Epifactor	RPS6KB1	MBIP	0.816956603	2.48E-20
UVM	Epifactor	RPS6KB1	VRK1	0.817298399	2.32E-20
UVM	Epifactor	RPS6KB1	SUDS3	0.819260422	1.58E-20
UVM	Epifactor	RPS6KB1	DDX50	0.819976327	1.38E-20
UVM	Epifactor	RPS6KB1	PPP4R2	0.820229401	1.31E-20
UVM	Epifactor	RPS6KB1	TDG	0.820327985	1.28E-20
UVM	Epifactor	RPS6KB1	CBX3	0.820739663	1.18E-20
UVM	Epifactor	RPS6KB1	EID1	0.821180378	1.09E-20
UVM	Epifactor	RPS6KB1	ERCC6	0.821556582	1.01E-20
UVM	Epifactor	RPS6KB1	BRWD3	0.82250194	8.34E-21
UVM	Epifactor	RPS6KB1	PHF14	0.823195835	7.26E-21
UVM	Epifactor	RPS6KB1	NFYB	0.82831865	2.56E-21
UVM	Epifactor	RPS6KB1	CHUK	0.828480926	2.47E-21
UVM	Epifactor	RPS6KB1	ZMYM2	0.832307059	1.11E-21
UVM	Epifactor	RPS6KB1	SMARCA5	0.832674666	1.03E-21
UVM	Epifactor	RPS6KB1	ACTR6	0.833065537	9.43E-22
UVM	Epifactor	RPS6KB1	CUL4B	0.83508658	6.11E-22
UVM	Epifactor	RPS6KB1	PARG	0.835341359	5.78E-22
UVM	Epifactor	RPS6KB1	MPHOSPH8	0.836187933	4.81E-22
UVM	Epifactor	RPS6KB1	PHC3	0.836540506	4.45E-22
UVM	Epifactor	RPS6KB1	ATRX	0.838445884	2.93E-22
UVM	Epifactor	RPS6KB1	RB1	0.839783155	2.18E-22
UVM	Epifactor	RPS6KB1	CDK17	0.845839831	5.46E-23
UVM	Epifactor	RPS6KB1	HCFC2	0.848979962	2.61E-23
UVM	Epifactor	RPS6KB1	RSF1	0.848991737	2.60E-23
UVM	Epifactor	RPS6KB1	BAZ1A	0.849136377	2.51E-23
UVM	Epifactor	RPS6KB1	SPOP	0.850985847	1.61E-23
UVM	Epifactor	RPS6KB1	TBL1XR1	0.851293693	1.50E-23
UVM	Epifactor	RPS6KB1	PHF20L1	0.852340644	1.16E-23
UVM	Epifactor	RPS6KB1	TRIM33	0.853366653	9.01E-24
UVM	Epifactor	RPS6KB1	MYSM1	0.853787413	8.13E-24
UVM	Epifactor	RPS6KB1	ATM	0.854724058	6.44E-24
UVM	Epifactor	RPS6KB1	HAT1	0.854971751	6.06E-24
UVM	Epifactor	RPS6KB1	MLLT10	0.855376132	5.48E-24
UVM	Epifactor	RPS6KB1	CIR1	0.855694159	5.06E-24
UVM	Epifactor	RPS6KB1	ARID2	0.857653667	3.09E-24
UVM	Epifactor	RPS6KB1	EPC1	0.857783848	2.99E-24
UVM	Epifactor	RPS6KB1	TADA1	0.858069404	2.78E-24
UVM	Epifactor	RPS6KB1	JAK2	0.859029388	2.17E-24
UVM	Epifactor	RPS6KB1	OGT	0.861733204	1.08E-24
UVM	Epifactor	RPS6KB1	PCGF6	0.862229249	9.45E-25
UVM	Epifactor	RPS6KB1	CTBP2	0.862407709	9.02E-25
UVM	Epifactor	RPS6KB1	TLK2	0.86282942	8.07E-25
UVM	Epifactor	RPS6KB1	HMGB1	0.865659136	3.78E-25
UVM	Epifactor	RPS6KB1	UCHL5	0.86681053	2.77E-25
UVM	Epifactor	RPS6KB1	DNTTIP2	0.867620906	2.22E-25
UVM	Epifactor	RPS6KB1	BRWD1	0.868192417	1.89E-25
UVM	Epifactor	RPS6KB1	USP15	0.871530615	7.44E-26
UVM	Epifactor	RPS6KB1	UHRF2	0.873465231	4.28E-26
UVM	Epifactor	RPS6KB1	MASTL	0.873909277	3.76E-26
UVM	Epifactor	RPS6KB1	DEK	0.875629301	2.28E-26
UVM	Epifactor	RPS6KB1	CLOCK	0.875788731	2.17E-26
UVM	Epifactor	RPS6KB1	ATF2	0.877748733	1.21E-26
UVM	Epifactor	RPS6KB1	ZRANB3	0.878699504	9.12E-27
UVM	Epifactor	RPS6KB1	ZMYND11	0.879575886	7.00E-27
UVM	Epifactor	RPS6KB1	BRMS1L	0.880427903	5.39E-27
UVM	Epifactor	RPS6KB1	FAM175B	0.881085615	4.41E-27
UVM	Epifactor	RPS6KB1	YY1	0.881862584	3.46E-27
UVM	Epifactor	RPS6KB1	MBTD1	0.88414372	1.69E-27
UVM	Epifactor	RPS6KB1	RLIM	0.884936929	1.32E-27
UVM	Epifactor	RPS6KB1	SMARCAD1	0.885231936	1.20E-27
UVM	Epifactor	RPS6KB1	RMI1	0.887159809	6.42E-28
UVM	Epifactor	RPS6KB1	TET2	0.888730623	3.83E-28
UVM	Epifactor	RPS6KB1	ATAD2B	0.893141955	8.63E-29
UVM	Epifactor	RPS6KB1	TLK1	0.894201187	5.97E-29
UVM	Epifactor	RPS6KB1	TAF7	0.895457943	3.84E-29
UVM	Epifactor	RPS6KB1	PHIP	0.8979556	1.57E-29
UVM	Epifactor	RPS6KB1	PRKAA1	0.899929089	7.62E-30
UVM	Epifactor	RPS6KB1	AEBP2	0.900029098	7.34E-30
UVM	Epifactor	RPS6KB1	ARID4B	0.900822461	5.46E-30
UVM	Epifactor	RPS6KB1	RCOR3	0.901246966	4.66E-30
UVM	Epifactor	RPS6KB1	BRCC3	0.901964082	3.56E-30
UVM	Epifactor	RPS6KB1	CHD1	0.902846366	2.54E-30
UVM	Epifactor	RPS6KB1	CUL5	0.903121363	2.29E-30
UVM	Epifactor	RPS6KB1	JMJD1C	0.903800859	1.76E-30
UVM	Epifactor	RPS6KB1	CUL3	0.904080797	1.58E-30
UVM	Epifactor	RPS6KB1	BAZ2B	0.904262498	1.47E-30
UVM	Epifactor	RPS6KB1	SIRT1	0.904506377	1.34E-30
UVM	Epifactor	RPS6KB1	SMEK1	0.907090546	4.84E-31
UVM	Epifactor	RPS6KB1	INO80D	0.908774595	2.45E-31
UVM	Epifactor	RPS6KB1	NSL1	0.908924067	2.30E-31
UVM	Epifactor	RPS6KB1	CHD9	0.911119756	9.28E-32
UVM	Epifactor	RPS6KB1	NIPBL	0.912774727	4.60E-32
UVM	Epifactor	RPS6KB1	CDC73	0.912919359	4.33E-32
UVM	Epifactor	RPS6KB1	ARID4A	0.92008665	1.74E-33
UVM	Epifactor	RPS6KB1	EPC2	0.926447203	7.76E-35
UVM	Epifactor	RPS6KB1	SF3B1	0.926484864	7.61E-35
UVM	Epifactor	RPS6KB1	SMEK2	0.928971283	2.09E-35
UVM	Epifactor	RPS6KB1	YEATS4	0.930188383	1.09E-35
UVM	Epifactor	RPS6KB1	CUL2	0.934719527	8.66E-37
UVM	Epifactor	RPS6KB1	SUZ12	0.93714705	2.07E-37
UVM	IUPHAR	RPS6KB1	ATP2B1	0.80113032	4.55E-19
UVM	IUPHAR	RPS6KB1	TAOK3	0.801132296	4.55E-19
UVM	IUPHAR	RPS6KB1	SLC38A2	0.801216017	4.48E-19
UVM	IUPHAR	RPS6KB1	SETDB2	0.801709843	4.11E-19
UVM	IUPHAR	RPS6KB1	ATR	0.804308976	2.59E-19
UVM	IUPHAR	RPS6KB1	SP100	0.8045273	2.49E-19
UVM	IUPHAR	RPS6KB1	RIOK2	0.807686321	1.41E-19
UVM	IUPHAR	RPS6KB1	CYP2R1	0.807793106	1.38E-19
UVM	IUPHAR	RPS6KB1	NFE2L2	0.80788343	1.36E-19
UVM	IUPHAR	RPS6KB1	TAS2R14	0.808124661	1.30E-19
UVM	IUPHAR	RPS6KB1	SLC19A2	0.808377772	1.24E-19
UVM	IUPHAR	RPS6KB1	PREPL	0.809059283	1.09E-19
UVM	IUPHAR	RPS6KB1	GNAQ	0.809150061	1.08E-19
UVM	IUPHAR	RPS6KB1	PLK4	0.809234433	1.06E-19
UVM	IUPHAR	RPS6KB1	CRBN	0.809269613	1.05E-19
UVM	IUPHAR	RPS6KB1	SLC39A10	0.809894286	9.39E-20
UVM	IUPHAR	RPS6KB1	PDIK1L	0.813765067	4.55E-20
UVM	IUPHAR	RPS6KB1	MAP2K4	0.816436863	2.74E-20
UVM	IUPHAR	RPS6KB1	VRK1	0.817298399	2.32E-20
UVM	IUPHAR	RPS6KB1	SPTLC1	0.817303311	2.32E-20
UVM	IUPHAR	RPS6KB1	MAP3K1	0.817759295	2.12E-20
UVM	IUPHAR	RPS6KB1	CSNK1A1	0.818123803	1.98E-20
UVM	IUPHAR	RPS6KB1	EGLN1	0.819972505	1.38E-20
UVM	IUPHAR	RPS6KB1	HIPK3	0.820012457	1.37E-20
UVM	IUPHAR	RPS6KB1	IL6ST	0.820639547	1.21E-20
UVM	IUPHAR	RPS6KB1	ABCB10	0.821189814	1.08E-20
UVM	IUPHAR	RPS6KB1	USP1	0.821239369	1.07E-20
UVM	IUPHAR	RPS6KB1	ATP6V0A2	0.822429042	8.47E-21
UVM	IUPHAR	RPS6KB1	BRWD3	0.82250194	8.34E-21
UVM	IUPHAR	RPS6KB1	PIP5K1A	0.823258965	7.17E-21
UVM	IUPHAR	RPS6KB1	ATP11B	0.823612576	6.68E-21
UVM	IUPHAR	RPS6KB1	BIRC6	0.824055554	6.11E-21
UVM	IUPHAR	RPS6KB1	MAGT1	0.826136015	4.01E-21
UVM	IUPHAR	RPS6KB1	PIK3C3	0.827247019	3.19E-21
UVM	IUPHAR	RPS6KB1	CHUK	0.828480926	2.47E-21
UVM	IUPHAR	RPS6KB1	STK17A	0.829674487	1.93E-21
UVM	IUPHAR	RPS6KB1	PIK3R1	0.830381754	1.66E-21
UVM	IUPHAR	RPS6KB1	GLS	0.832138244	1.15E-21
UVM	IUPHAR	RPS6KB1	PSMD14	0.832975883	9.62E-22
UVM	IUPHAR	RPS6KB1	SLC2A13	0.833552967	8.50E-22
UVM	IUPHAR	RPS6KB1	SLC25A24	0.8337247	8.19E-22
UVM	IUPHAR	RPS6KB1	ACVR2A	0.834251689	7.32E-22
UVM	IUPHAR	RPS6KB1	YES1	0.834343098	7.17E-22
UVM	IUPHAR	RPS6KB1	HMGCS1	0.834780996	6.53E-22
UVM	IUPHAR	RPS6KB1	ABCD3	0.835000147	6.23E-22
UVM	IUPHAR	RPS6KB1	ABCA5	0.836780806	4.23E-22
UVM	IUPHAR	RPS6KB1	DYRK1A	0.837607458	3.52E-22
UVM	IUPHAR	RPS6KB1	SLC30A9	0.838183813	3.10E-22
UVM	IUPHAR	RPS6KB1	SENP6	0.838557804	2.86E-22
UVM	IUPHAR	RPS6KB1	PRMT3	0.840766361	1.75E-22
UVM	IUPHAR	RPS6KB1	RPS6KC1	0.841029077	1.65E-22
UVM	IUPHAR	RPS6KB1	ADAM17	0.84545637	5.97E-23
UVM	IUPHAR	RPS6KB1	MFN1	0.845666057	5.69E-23
UVM	IUPHAR	RPS6KB1	CDK17	0.845839831	5.46E-23
UVM	IUPHAR	RPS6KB1	HSP90AA1	0.846464128	4.72E-23
UVM	IUPHAR	RPS6KB1	SENP7	0.847716771	3.52E-23
UVM	IUPHAR	RPS6KB1	BAZ1A	0.849136377	2.51E-23
UVM	IUPHAR	RPS6KB1	SLC4A7	0.852275549	1.18E-23
UVM	IUPHAR	RPS6KB1	TRIM33	0.853366653	9.01E-24
UVM	IUPHAR	RPS6KB1	PPAT	0.854118761	7.49E-24
UVM	IUPHAR	RPS6KB1	ATM	0.854724058	6.44E-24
UVM	IUPHAR	RPS6KB1	ITGAV	0.854922684	6.13E-24
UVM	IUPHAR	RPS6KB1	HAT1	0.854971751	6.06E-24
UVM	IUPHAR	RPS6KB1	USP14	0.856683556	3.95E-24
UVM	IUPHAR	RPS6KB1	STK38L	0.856891155	3.74E-24
UVM	IUPHAR	RPS6KB1	IRAK4	0.856893561	3.74E-24
UVM	IUPHAR	RPS6KB1	IDI1	0.857790201	2.98E-24
UVM	IUPHAR	RPS6KB1	CLK1	0.858106814	2.75E-24
UVM	IUPHAR	RPS6KB1	JAK2	0.859029388	2.17E-24
UVM	IUPHAR	RPS6KB1	CLK4	0.859787004	1.79E-24
UVM	IUPHAR	RPS6KB1	PIK3CA	0.862298769	9.28E-25
UVM	IUPHAR	RPS6KB1	SLC25A46	0.86281572	8.10E-25
UVM	IUPHAR	RPS6KB1	TLK2	0.86282942	8.07E-25
UVM	IUPHAR	RPS6KB1	SCYL2	0.863223437	7.27E-25
UVM	IUPHAR	RPS6KB1	PLA2G12A	0.864306691	5.44E-25
UVM	IUPHAR	RPS6KB1	SMG1	0.864355413	5.37E-25
UVM	IUPHAR	RPS6KB1	MAPK6	0.864718236	4.88E-25
UVM	IUPHAR	RPS6KB1	BRWD1	0.868192417	1.89E-25
UVM	IUPHAR	RPS6KB1	TBK1	0.871237117	8.08E-26
UVM	IUPHAR	RPS6KB1	BMPR1A	0.871487943	7.53E-26
UVM	IUPHAR	RPS6KB1	MAP3K2	0.872849475	5.10E-26
UVM	IUPHAR	RPS6KB1	MTR	0.87364561	4.06E-26
UVM	IUPHAR	RPS6KB1	MASTL	0.873909277	3.76E-26
UVM	IUPHAR	RPS6KB1	KRAS	0.874143026	3.51E-26
UVM	IUPHAR	RPS6KB1	PKN2	0.875161931	2.61E-26
UVM	IUPHAR	RPS6KB1	CLOCK	0.875788731	2.17E-26
UVM	IUPHAR	RPS6KB1	SLK	0.876144025	1.96E-26
UVM	IUPHAR	RPS6KB1	MALT1	0.877353837	1.37E-26
UVM	IUPHAR	RPS6KB1	SLC30A5	0.877855661	1.18E-26
UVM	IUPHAR	RPS6KB1	VRK2	0.878257793	1.04E-26
UVM	IUPHAR	RPS6KB1	NR2C1	0.878573061	9.48E-27
UVM	IUPHAR	RPS6KB1	NR3C1	0.878923011	8.53E-27
UVM	IUPHAR	RPS6KB1	ZMYND11	0.879575886	7.00E-27
UVM	IUPHAR	RPS6KB1	TNKS2	0.884760938	1.39E-27
UVM	IUPHAR	RPS6KB1	RIOK3	0.885053448	1.27E-27
UVM	IUPHAR	RPS6KB1	NAPEPLD	0.890586314	2.06E-28
UVM	IUPHAR	RPS6KB1	XIAP	0.89117985	1.69E-28
UVM	IUPHAR	RPS6KB1	NEK1	0.891630934	1.45E-28
UVM	IUPHAR	RPS6KB1	MAP4K3	0.892703029	1.00E-28
UVM	IUPHAR	RPS6KB1	ATAD2B	0.893141955	8.63E-29
UVM	IUPHAR	RPS6KB1	CSNK1G3	0.893239428	8.34E-29
UVM	IUPHAR	RPS6KB1	TLK1	0.894201187	5.97E-29
UVM	IUPHAR	RPS6KB1	BIRC2	0.894863251	4.74E-29
UVM	IUPHAR	RPS6KB1	PRPF4B	0.896519861	2.63E-29
UVM	IUPHAR	RPS6KB1	BMPR2	0.897891166	1.61E-29
UVM	IUPHAR	RPS6KB1	PHIP	0.8979556	1.57E-29
UVM	IUPHAR	RPS6KB1	XPO1	0.899725947	8.21E-30
UVM	IUPHAR	RPS6KB1	NEK7	0.899851617	7.84E-30
UVM	IUPHAR	RPS6KB1	PRKAA1	0.899929089	7.62E-30
UVM	IUPHAR	RPS6KB1	JMJD1C	0.903800859	1.76E-30
UVM	IUPHAR	RPS6KB1	BAZ2B	0.904262498	1.47E-30
UVM	IUPHAR	RPS6KB1	SIRT1	0.904506377	1.34E-30
UVM	IUPHAR	RPS6KB1	PIKFYVE	0.912142588	6.03E-32
UVM	IUPHAR	RPS6KB1	TRPM7	0.912467649	5.25E-32
UVM	IUPHAR	RPS6KB1	FBXO11	0.916069687	1.09E-32
UVM	Kinase	RPS6KB1	TAOK3	0.801132296	4.55E-19
UVM	Kinase	RPS6KB1	ATR	0.804308976	2.59E-19
UVM	Kinase	RPS6KB1	RIOK2	0.807686321	1.41E-19
UVM	Kinase	RPS6KB1	PLK4	0.809234433	1.06E-19
UVM	Kinase	RPS6KB1	SCYL3	0.810935381	7.74E-20
UVM	Kinase	RPS6KB1	PDIK1L	0.813765067	4.55E-20
UVM	Kinase	RPS6KB1	MAP2K4	0.816436863	2.74E-20
UVM	Kinase	RPS6KB1	VRK1	0.817298399	2.32E-20
UVM	Kinase	RPS6KB1	MAP3K1	0.817759295	2.12E-20
UVM	Kinase	RPS6KB1	CSNK1A1	0.818123803	1.98E-20
UVM	Kinase	RPS6KB1	HIPK3	0.820012457	1.37E-20
UVM	Kinase	RPS6KB1	CHUK	0.828480926	2.47E-21
UVM	Kinase	RPS6KB1	STK17A	0.829674487	1.93E-21
UVM	Kinase	RPS6KB1	ACVR2A	0.834251689	7.32E-22
UVM	Kinase	RPS6KB1	YES1	0.834343098	7.17E-22
UVM	Kinase	RPS6KB1	DYRK1A	0.837607458	3.52E-22
UVM	Kinase	RPS6KB1	RPS6KC1	0.841029077	1.65E-22
UVM	Kinase	RPS6KB1	CDK17	0.845839831	5.46E-23
UVM	Kinase	RPS6KB1	BAZ1A	0.849136377	2.51E-23
UVM	Kinase	RPS6KB1	TRIM33	0.853366653	9.01E-24
UVM	Kinase	RPS6KB1	ATM	0.854724058	6.44E-24
UVM	Kinase	RPS6KB1	STK38L	0.856891155	3.74E-24
UVM	Kinase	RPS6KB1	IRAK4	0.856893561	3.74E-24
UVM	Kinase	RPS6KB1	CLK1	0.858106814	2.75E-24
UVM	Kinase	RPS6KB1	JAK2	0.859029388	2.17E-24
UVM	Kinase	RPS6KB1	CLK4	0.859787004	1.79E-24
UVM	Kinase	RPS6KB1	TLK2	0.86282942	8.07E-25
UVM	Kinase	RPS6KB1	SCYL2	0.863223437	7.27E-25
UVM	Kinase	RPS6KB1	SMG1	0.864355413	5.37E-25
UVM	Kinase	RPS6KB1	MAPK6	0.864718236	4.88E-25
UVM	Kinase	RPS6KB1	COL4A3BP	0.865909733	3.54E-25
UVM	Kinase	RPS6KB1	PAN3	0.86966779	1.26E-25
UVM	Kinase	RPS6KB1	TBK1	0.871237117	8.08E-26
UVM	Kinase	RPS6KB1	BMPR1A	0.871487943	7.53E-26
UVM	Kinase	RPS6KB1	MAP3K2	0.872849475	5.10E-26
UVM	Kinase	RPS6KB1	MASTL	0.873909277	3.76E-26
UVM	Kinase	RPS6KB1	PKN2	0.875161931	2.61E-26
UVM	Kinase	RPS6KB1	SLK	0.876144025	1.96E-26
UVM	Kinase	RPS6KB1	VRK2	0.878257793	1.04E-26
UVM	Kinase	RPS6KB1	RIOK3	0.885053448	1.27E-27
UVM	Kinase	RPS6KB1	NEK1	0.891630934	1.45E-28
UVM	Kinase	RPS6KB1	MAP4K3	0.892703029	1.00E-28
UVM	Kinase	RPS6KB1	CSNK1G3	0.893239428	8.34E-29
UVM	Kinase	RPS6KB1	TLK1	0.894201187	5.97E-29
UVM	Kinase	RPS6KB1	PRPF4B	0.896519861	2.63E-29
UVM	Kinase	RPS6KB1	BMPR2	0.897891166	1.61E-29
UVM	Kinase	RPS6KB1	NEK7	0.899851617	7.84E-30
UVM	Kinase	RPS6KB1	PRKAA1	0.899929089	7.62E-30
UVM	Kinase	RPS6KB1	TRPM7	0.912467649	5.25E-32
UVM	TF	RPS6KB1	ZNF20	0.800316616	5.25E-19
UVM	TF	RPS6KB1	ZNF502	0.800753668	4.86E-19
UVM	TF	RPS6KB1	ZUFSP	0.801162296	4.53E-19
UVM	TF	RPS6KB1	SETDB2	0.801709843	4.11E-19
UVM	TF	RPS6KB1	ZNF101	0.803432225	3.03E-19
UVM	TF	RPS6KB1	ZNF100	0.803837501	2.82E-19
UVM	TF	RPS6KB1	ZNF714	0.803920171	2.78E-19
UVM	TF	RPS6KB1	MGA	0.803954162	2.76E-19
UVM	TF	RPS6KB1	SP100	0.8045273	2.49E-19
UVM	TF	RPS6KB1	ZBTB49	0.805056707	2.27E-19
UVM	TF	RPS6KB1	TTF1	0.806509548	1.74E-19
UVM	TF	RPS6KB1	ZNF281	0.806884715	1.63E-19
UVM	TF	RPS6KB1	ZBTB44	0.806998692	1.60E-19
UVM	TF	RPS6KB1	MTF2	0.807626405	1.42E-19
UVM	TF	RPS6KB1	NFE2L2	0.80788343	1.36E-19
UVM	TF	RPS6KB1	HIF1A	0.807907721	1.35E-19
UVM	TF	RPS6KB1	ZNF564	0.808156112	1.29E-19
UVM	TF	RPS6KB1	ZNF557	0.808197205	1.28E-19
UVM	TF	RPS6KB1	ZNF655	0.809637457	9.84E-20
UVM	TF	RPS6KB1	ZNF765	0.810809418	7.92E-20
UVM	TF	RPS6KB1	ZNF189	0.811469763	7.01E-20
UVM	TF	RPS6KB1	ZNF507	0.812341894	5.95E-20
UVM	TF	RPS6KB1	ZNF184	0.815288144	3.41E-20
UVM	TF	RPS6KB1	ADNP2	0.815451518	3.30E-20
UVM	TF	RPS6KB1	ZNF600	0.816472419	2.72E-20
UVM	TF	RPS6KB1	SKIL	0.816514387	2.70E-20
UVM	TF	RPS6KB1	ZNF587	0.817585587	2.19E-20
UVM	TF	RPS6KB1	CDC5L	0.817890547	2.07E-20
UVM	TF	RPS6KB1	ZNF480	0.819191167	1.60E-20
UVM	TF	RPS6KB1	THAP2	0.819894777	1.40E-20
UVM	TF	RPS6KB1	ZNF354A	0.821914188	9.38E-21
UVM	TF	RPS6KB1	ZNF443	0.822293379	8.70E-21
UVM	TF	RPS6KB1	ZNF678	0.824271087	5.85E-21
UVM	TF	RPS6KB1	ZNF615	0.825224356	4.83E-21
UVM	TF	RPS6KB1	ZNF799	0.825596159	4.47E-21
UVM	TF	RPS6KB1	ZNF225	0.826470314	3.74E-21
UVM	TF	RPS6KB1	HDX	0.827255998	3.19E-21
UVM	TF	RPS6KB1	ELK3	0.827417587	3.08E-21
UVM	TF	RPS6KB1	ZNF280C	0.827474964	3.05E-21
UVM	TF	RPS6KB1	NFYB	0.82831865	2.56E-21
UVM	TF	RPS6KB1	ZNF92	0.828346473	2.54E-21
UVM	TF	RPS6KB1	ZNF654	0.82914233	2.16E-21
UVM	TF	RPS6KB1	ZNF146	0.829465563	2.02E-21
UVM	TF	RPS6KB1	ZNF266	0.830698511	1.56E-21
UVM	TF	RPS6KB1	ZNF493	0.830705587	1.56E-21
UVM	TF	RPS6KB1	ZNF236	0.830718511	1.55E-21
UVM	TF	RPS6KB1	ZNF222	0.831174912	1.41E-21
UVM	TF	RPS6KB1	LCOR	0.831515183	1.31E-21
UVM	TF	RPS6KB1	ZNF627	0.831786239	1.24E-21
UVM	TF	RPS6KB1	ZNF138	0.832329716	1.10E-21
UVM	TF	RPS6KB1	ZNF529	0.83278567	1.00E-21
UVM	TF	RPS6KB1	ZNF17	0.832903671	9.77E-22
UVM	TF	RPS6KB1	ZNF614	0.833846459	7.98E-22
UVM	TF	RPS6KB1	ZNF555	0.834057521	7.63E-22
UVM	TF	RPS6KB1	SP4	0.83590026	5.12E-22
UVM	TF	RPS6KB1	ZNF45	0.835948538	5.07E-22
UVM	TF	RPS6KB1	ZNF808	0.836386583	4.61E-22
UVM	TF	RPS6KB1	ZNF585A	0.836764898	4.24E-22
UVM	TF	RPS6KB1	ZNF91	0.837917867	3.29E-22
UVM	TF	RPS6KB1	ZNF585B	0.838055289	3.19E-22
UVM	TF	RPS6KB1	ZNF81	0.838612697	2.82E-22
UVM	TF	RPS6KB1	ZNF558	0.839680576	2.23E-22
UVM	TF	RPS6KB1	JRKL	0.839730864	2.20E-22
UVM	TF	RPS6KB1	ZC3H8	0.840674795	1.78E-22
UVM	TF	RPS6KB1	PRMT3	0.840766361	1.75E-22
UVM	TF	RPS6KB1	ZNF674	0.841846922	1.37E-22
UVM	TF	RPS6KB1	ZNF223	0.842165463	1.27E-22
UVM	TF	RPS6KB1	ELF1	0.843101144	1.03E-22
UVM	TF	RPS6KB1	ZNF680	0.845037689	6.58E-23
UVM	TF	RPS6KB1	ZNF224	0.846348835	4.85E-23
UVM	TF	RPS6KB1	RLF	0.846651103	4.52E-23
UVM	TF	RPS6KB1	ZNF292	0.847145751	4.03E-23
UVM	TF	RPS6KB1	ZNF326	0.847314342	3.87E-23
UVM	TF	RPS6KB1	ZNF782	0.848082743	3.23E-23
UVM	TF	RPS6KB1	ZNF347	0.849825279	2.13E-23
UVM	TF	RPS6KB1	ZNF141	0.849941673	2.07E-23
UVM	TF	RPS6KB1	ZNF10	0.851483968	1.43E-23
UVM	TF	RPS6KB1	ZNF253	0.852445181	1.13E-23
UVM	TF	RPS6KB1	ZNF546	0.852470393	1.12E-23
UVM	TF	RPS6KB1	ZNF449	0.853676687	8.35E-24
UVM	TF	RPS6KB1	MYSM1	0.853787413	8.13E-24
UVM	TF	RPS6KB1	ZNF200	0.854618234	6.62E-24
UVM	TF	RPS6KB1	ZNF160	0.85667403	3.95E-24
UVM	TF	RPS6KB1	ARID2	0.857653667	3.09E-24
UVM	TF	RPS6KB1	ATF1	0.858042967	2.79E-24
UVM	TF	RPS6KB1	ZNF227	0.858914736	2.24E-24
UVM	TF	RPS6KB1	BACH1	0.858984446	2.20E-24
UVM	TF	RPS6KB1	EEA1	0.859665938	1.84E-24
UVM	TF	RPS6KB1	ZNF611	0.860338653	1.55E-24
UVM	TF	RPS6KB1	ZNF235	0.860350847	1.54E-24
UVM	TF	RPS6KB1	ZNF569	0.860698063	1.41E-24
UVM	TF	RPS6KB1	ZNF461	0.861060401	1.28E-24
UVM	TF	RPS6KB1	ZNF23	0.861083593	1.28E-24
UVM	TF	RPS6KB1	ZNF226	0.861682695	1.09E-24
UVM	TF	RPS6KB1	ZNF84	0.862090785	9.80E-25
UVM	TF	RPS6KB1	PCGF6	0.862229249	9.45E-25
UVM	TF	RPS6KB1	ZNF260	0.862834015	8.06E-25
UVM	TF	RPS6KB1	ZNF26	0.863517819	6.72E-25
UVM	TF	RPS6KB1	PURB	0.863623616	6.53E-25
UVM	TF	RPS6KB1	ZNF383	0.86419508	5.61E-25
UVM	TF	RPS6KB1	ZNF75D	0.864622758	5.00E-25
UVM	TF	RPS6KB1	ZNF37A	0.865885593	3.56E-25
UVM	TF	RPS6KB1	ZNF302	0.867027076	2.61E-25
UVM	TF	RPS6KB1	ZNF41	0.867091738	2.56E-25
UVM	TF	RPS6KB1	THAP1	0.867097199	2.56E-25
UVM	TF	RPS6KB1	ZNF644	0.867388765	2.36E-25
UVM	TF	RPS6KB1	ZNF451	0.868387601	1.79E-25
UVM	TF	RPS6KB1	ZNF721	0.868718576	1.64E-25
UVM	TF	RPS6KB1	ZFP14	0.869207843	1.43E-25
UVM	TF	RPS6KB1	ZNF182	0.870419077	1.02E-25
UVM	TF	RPS6KB1	ZNF420	0.870519355	9.90E-26
UVM	TF	RPS6KB1	ZNF470	0.871335853	7.86E-26
UVM	TF	RPS6KB1	ZNF780B	0.871833991	6.82E-26
UVM	TF	RPS6KB1	ZNF320	0.87184491	6.80E-26
UVM	TF	RPS6KB1	ZNF606	0.872632398	5.43E-26
UVM	TF	RPS6KB1	ZNF780A	0.872797945	5.18E-26
UVM	TF	RPS6KB1	ZNF25	0.873138643	4.70E-26
UVM	TF	RPS6KB1	ZNF468	0.873210795	4.60E-26
UVM	TF	RPS6KB1	ZNF700	0.873448567	4.30E-26
UVM	TF	RPS6KB1	ZNF484	0.873629159	4.08E-26
UVM	TF	RPS6KB1	ZNF440	0.874280841	3.38E-26
UVM	TF	RPS6KB1	NFXL1	0.87442521	3.24E-26
UVM	TF	RPS6KB1	ZNF248	0.874990744	2.75E-26
UVM	TF	RPS6KB1	CLOCK	0.875788731	2.17E-26
UVM	TF	RPS6KB1	ZFX	0.875996586	2.04E-26
UVM	TF	RPS6KB1	CREBZF	0.876548879	1.74E-26
UVM	TF	RPS6KB1	ZNF675	0.876843792	1.59E-26
UVM	TF	RPS6KB1	ZNF397	0.877262111	1.40E-26
UVM	TF	RPS6KB1	ZNF268	0.877462041	1.32E-26
UVM	TF	RPS6KB1	ZNF761	0.877573618	1.28E-26
UVM	TF	RPS6KB1	ZNF566	0.877626608	1.26E-26
UVM	TF	RPS6KB1	ZBTB11	0.877711163	1.23E-26
UVM	TF	RPS6KB1	ATF2	0.877748733	1.21E-26
UVM	TF	RPS6KB1	ZNF83	0.877768673	1.21E-26
UVM	TF	RPS6KB1	ZNF624	0.878398429	9.99E-27
UVM	TF	RPS6KB1	NR2C1	0.878573061	9.48E-27
UVM	TF	RPS6KB1	NR3C1	0.878923011	8.53E-27
UVM	TF	RPS6KB1	ZNF44	0.879831267	6.47E-27
UVM	TF	RPS6KB1	ZNF140	0.880000948	6.15E-27
UVM	TF	RPS6KB1	ZNF181	0.881287609	4.14E-27
UVM	TF	RPS6KB1	ZNF254	0.881832159	3.50E-27
UVM	TF	RPS6KB1	YY1	0.881862584	3.46E-27
UVM	TF	RPS6KB1	ZNF845	0.882313638	3.01E-27
UVM	TF	RPS6KB1	SMAD4	0.88275169	2.63E-27
UVM	TF	RPS6KB1	ZNF267	0.883348155	2.18E-27
UVM	TF	RPS6KB1	MYNN	0.883403954	2.14E-27
UVM	TF	RPS6KB1	ZNF12	0.883801104	1.89E-27
UVM	TF	RPS6KB1	ZNF658	0.883906846	1.83E-27
UVM	TF	RPS6KB1	ZNF708	0.88427556	1.62E-27
UVM	TF	RPS6KB1	ZBED5	0.884675903	1.43E-27
UVM	TF	RPS6KB1	ZNF43	0.885070184	1.26E-27
UVM	TF	RPS6KB1	TOPORS	0.885826501	9.89E-28
UVM	TF	RPS6KB1	RBAK	0.886533619	7.87E-28
UVM	TF	RPS6KB1	ZBTB6	0.88681476	7.19E-28
UVM	TF	RPS6KB1	ZNF354B	0.887485119	5.77E-28
UVM	TF	RPS6KB1	ZNF518A	0.888186801	4.59E-28
UVM	TF	RPS6KB1	TET2	0.888730623	3.83E-28
UVM	TF	RPS6KB1	ZNF148	0.88903669	3.46E-28
UVM	TF	RPS6KB1	VEZF1	0.889402752	3.07E-28
UVM	TF	RPS6KB1	IKZF5	0.891124844	1.72E-28
UVM	TF	RPS6KB1	ZNF33A	0.891514196	1.51E-28
UVM	TF	RPS6KB1	FOXN2	0.891569931	1.48E-28
UVM	TF	RPS6KB1	ZNF800	0.89242013	1.11E-28
UVM	TF	RPS6KB1	TMF1	0.893711533	7.08E-29
UVM	TF	RPS6KB1	ZNF441	0.894089347	6.21E-29
UVM	TF	RPS6KB1	ZNF131	0.894462515	5.45E-29
UVM	TF	RPS6KB1	ZNF430	0.895313726	4.04E-29
UVM	TF	RPS6KB1	ZNF791	0.895436051	3.87E-29
UVM	TF	RPS6KB1	ZNF280D	0.895529409	3.74E-29
UVM	TF	RPS6KB1	ZNF234	0.895864862	3.32E-29
UVM	TF	RPS6KB1	CEBPZ	0.895887955	3.30E-29
UVM	TF	RPS6KB1	ZNF195	0.897201836	2.06E-29
UVM	TF	RPS6KB1	PRDM10	0.89823156	1.42E-29
UVM	TF	RPS6KB1	ZNF567	0.89884153	1.14E-29
UVM	TF	RPS6KB1	AEBP2	0.900029098	7.34E-30
UVM	TF	RPS6KB1	ZNF143	0.900506947	6.15E-30
UVM	TF	RPS6KB1	ZNF14	0.902891808	2.50E-30
UVM	TF	RPS6KB1	GPBP1	0.903395281	2.06E-30
UVM	TF	RPS6KB1	BAZ2B	0.904262498	1.47E-30
UVM	TF	RPS6KB1	MEF2A	0.905104373	1.06E-30
UVM	TF	RPS6KB1	ZNF432	0.906113596	7.14E-31
UVM	TF	RPS6KB1	ZNF24	0.906495961	6.13E-31
UVM	TF	RPS6KB1	ZNF701	0.907180976	4.66E-31
UVM	TF	RPS6KB1	GABPA	0.908729218	2.49E-31
UVM	TF	RPS6KB1	ZNF527	0.909031143	2.20E-31
UVM	TF	RPS6KB1	ZBTB41	0.909460457	1.85E-31
UVM	TF	RPS6KB1	ZNF180	0.909500316	1.82E-31
UVM	TF	RPS6KB1	ZNF431	0.915388569	1.48E-32
UVM	TF	RPS6KB1	AHCTF1	0.915971229	1.14E-32
UVM	TF	RPS6KB1	ELF2	0.916500355	9.01E-33
UVM	TF	RPS6KB1	ZNF136	0.917024009	7.12E-33
UVM	TF	RPS6KB1	DMTF1	0.918900946	3.03E-33
UVM	TF	RPS6KB1	ZNF510	0.920160654	1.68E-33
UVM	TF	RPS6KB1	ZNF28	0.920188676	1.66E-33
UVM	TF	RPS6KB1	THAP9	0.921905556	7.36E-34
UVM	TF	RPS6KB1	THAP5	0.921943875	7.22E-34
UVM	TF	RPS6KB1	SMAD5	0.924018188	2.63E-34
UVM	TF	RPS6KB1	LIN54	0.924283718	2.30E-34
UVM	TF	RPS6KB1	ZBTB1	0.925498694	1.26E-34
UVM	TF	RPS6KB1	SP3	0.935509892	5.47E-37
UVM	TF	RPS6KB1	THAP6	0.939942739	3.70E-38
UVM	TF	RPS6KB1	CREB1	0.941853728	1.09E-38
UVM	TSG	RPS6KB1	ARL6IP5	0.803257989	3.13E-19
UVM	TSG	RPS6KB1	ATR	0.804308976	2.59E-19
UVM	TSG	RPS6KB1	SP100	0.8045273	2.49E-19
UVM	TSG	RPS6KB1	TTF1	0.806509548	1.74E-19
UVM	TSG	RPS6KB1	HIF1A	0.807907721	1.35E-19
UVM	TSG	RPS6KB1	ING3	0.811558703	6.89E-20
UVM	TSG	RPS6KB1	RCHY1	0.815216718	3.46E-20
UVM	TSG	RPS6KB1	SHPRH	0.815530311	3.26E-20
UVM	TSG	RPS6KB1	MAP2K4	0.816436863	2.74E-20
UVM	TSG	RPS6KB1	SKIL	0.816514387	2.70E-20
UVM	TSG	RPS6KB1	ANXA7	0.817562078	2.20E-20
UVM	TSG	RPS6KB1	PTPN2	0.817970124	2.04E-20
UVM	TSG	RPS6KB1	CSNK1A1	0.818123803	1.98E-20
UVM	TSG	RPS6KB1	CDKN1B	0.819198056	1.60E-20
UVM	TSG	RPS6KB1	EGLN1	0.819972505	1.38E-20
UVM	TSG	RPS6KB1	RBBP8	0.824722934	5.34E-21
UVM	TSG	RPS6KB1	PNN	0.825648094	4.43E-21
UVM	TSG	RPS6KB1	CHUK	0.828480926	2.47E-21
UVM	TSG	RPS6KB1	PTPN12	0.830175182	1.74E-21
UVM	TSG	RPS6KB1	FBXW7	0.831095808	1.43E-21
UVM	TSG	RPS6KB1	IFT88	0.835953403	5.06E-22
UVM	TSG	RPS6KB1	PHC3	0.836540506	4.45E-22
UVM	TSG	RPS6KB1	RB1	0.839783155	2.18E-22
UVM	TSG	RPS6KB1	PALB2	0.841354531	1.53E-22
UVM	TSG	RPS6KB1	PDS5B	0.841477688	1.49E-22
UVM	TSG	RPS6KB1	APC	0.844806355	6.95E-23
UVM	TSG	RPS6KB1	ZNF292	0.847145751	4.03E-23
UVM	TSG	RPS6KB1	SPOP	0.850985847	1.61E-23
UVM	TSG	RPS6KB1	APAF1	0.851697923	1.36E-23
UVM	TSG	RPS6KB1	ATM	0.854724058	6.44E-24
UVM	TSG	RPS6KB1	ITGAV	0.854922684	6.13E-24
UVM	TSG	RPS6KB1	ARID2	0.857653667	3.09E-24
UVM	TSG	RPS6KB1	RB1CC1	0.858542947	2.46E-24
UVM	TSG	RPS6KB1	FAM188A	0.859172813	2.09E-24
UVM	TSG	RPS6KB1	COPS2	0.862416097	9.00E-25
UVM	TSG	RPS6KB1	PHF6	0.863664933	6.46E-25
UVM	TSG	RPS6KB1	WDR11	0.863901028	6.07E-25
UVM	TSG	RPS6KB1	LIN9	0.867900441	2.05E-25
UVM	TSG	RPS6KB1	CCAR1	0.86946313	1.33E-25
UVM	TSG	RPS6KB1	RINT1	0.871035769	8.56E-26
UVM	TSG	RPS6KB1	BMPR1A	0.871487943	7.53E-26
UVM	TSG	RPS6KB1	MSH2	0.872641725	5.42E-26
UVM	TSG	RPS6KB1	UHRF2	0.873465231	4.28E-26
UVM	TSG	RPS6KB1	USP33	0.876938381	1.55E-26
UVM	TSG	RPS6KB1	GGNBP2	0.878807325	8.83E-27
UVM	TSG	RPS6KB1	ZMYND11	0.879575886	7.00E-27
UVM	TSG	RPS6KB1	NEDD4	0.882295039	3.03E-27
UVM	TSG	RPS6KB1	SMAD4	0.88275169	2.63E-27
UVM	TSG	RPS6KB1	TOPORS	0.885826501	9.89E-28
UVM	TSG	RPS6KB1	DICER1	0.888556371	4.06E-28
UVM	TSG	RPS6KB1	TET2	0.888730623	3.83E-28
UVM	TSG	RPS6KB1	GORAB	0.890342495	2.24E-28
UVM	TSG	RPS6KB1	NAPEPLD	0.890586314	2.06E-28
UVM	TSG	RPS6KB1	INTS6	0.894642283	5.12E-29
UVM	TSG	RPS6KB1	MLH3	0.897280854	2.00E-29
UVM	TSG	RPS6KB1	DCLRE1A	0.897778002	1.67E-29
UVM	TSG	RPS6KB1	BMPR2	0.897891166	1.61E-29
UVM	TSG	RPS6KB1	PRKAA1	0.899929089	7.62E-30
UVM	TSG	RPS6KB1	CHD1	0.902846366	2.54E-30
UVM	TSG	RPS6KB1	CUL5	0.903121363	2.29E-30
UVM	TSG	RPS6KB1	SMCHD1	0.904139484	1.55E-30
UVM	TSG	RPS6KB1	SIRT1	0.904506377	1.34E-30
UVM	TSG	RPS6KB1	PPM1A	0.912591551	4.98E-32
UVM	TSG	RPS6KB1	CDC73	0.912919359	4.33E-32
UVM	TSG	RPS6KB1	DMTF1	0.918900946	3.03E-33
UVM	TSG	RPS6KB1	VEZT	0.923717921	3.05E-34
UVM	TSG	RPS6KB1	KRIT1	0.927249866	5.13E-35
UVM	TSG	RPS6KB1	TANK	0.929540259	1.54E-35
UVM	TSG	RPS6KB1	CUL2	0.934719527	8.66E-37
UVM	TSG	RPS6KB1	SUZ12	0.93714705	2.07E-37

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRC	RPS6KB1	RPS6	-3.4556058277803	0.0001224322154943
THCA	RPS6KB1	POLDIP3	-1.36570096217917	0.000163098851560177
BRCA	RPS6KB1	RHEB	-1.34423616302394	0.00103883851257192
THCA	RPS6KB1	RPS6	1.46346143665389	0.00305071956645465
CHOL	RPS6KB1	RPTOR	-2.34317187916664	0.00390625
KIRP	RPS6KB1	RPS6	-1.15360907834159	0.0111397774890065
COAD	RPS6KB1	RPS6	1.03379589520851	0.011966735124588
BLCA	RPS6KB1	RPS6	-1.76940777579938	0.012359619140625
UCEC	RPS6KB1	IRS1	-2.15562069053176	0.015625
KICH	RPS6KB1	RHEB	1.83191315229171	0.0236499309539795
LUAD	RPS6KB1	MLST8	-1.0067433555627	1.03207777888518e-06
BRCA	RPS6KB1	MLST8	-1.86304443127359	1.06372586581501e-16
BRCA	RPS6KB1	IRS1	-1.3249458760778	2.02139514341716e-15
LUSC	RPS6KB1	MLST8	-2.07059311474544	3.67421243367441e-07
THCA	RPS6KB1	IRS1	-1.72997935219705	3.82403518090519e-10
HNSC	RPS6KB1	IRS1	2.20124565101457	3.84812503853028e-05
PRAD	RPS6KB1	RHEB	1.54870835586921	4.59461327401057e-05
LUSC	RPS6KB1	PIK3CA	2.04220246173083	6.19161914824481e-08
KICH	RPS6KB1	EIF4E	1.61675210562671	6.55651092529297e-06
LIHC	RPS6KB1	RPTOR	-4.36362270436135	6.64579404273587e-07
BRCA	RPS6KB1	RICTOR	-1.23696248638589	7.64567674547321e-05
PRAD	RPS6KB1	MTOR	2.45767376269894	8.16442831201447e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS6KB1

TRAF4, AKT1, CSNK2B, MTOR, GDI2P1, PPP2R2A, ACTA1, BTK, CSNK2A1, LYN, PDK1, PRKCZ, SRC, SYK, EIF3B, EIF3C, RPTOR, COASY, POLDIP3, RICTOR, TERT, XPO1, EIF3F, EEF2K, Xpo1, RBX1, MDM2, EP300, KAT2B, NEDD4, DPPA4, CLEC3B, MXD1, tor2, ELAVL1, NFATC1, EIF3H, SQSTM1, MAPKAP1, RPS6, PLD2, IRS1, APP, MAPT, HSP90AA1, URI1, STAT1, KIR3DL1, MAPK8, tor1, TRIB2, HTT, NCBP1, EIF4E, RHEB, NR1I2, RPS6KB1, PPP5C, STK11, DEPTOR, PIP4K2A, KIT, RRM2, VHL, ABL1, UBL4A, TRIM25, IRS2, HNRNPL, FBXO7, ESR2, AGR2, MXI1, PDGFRB, USP11, DYNC1LI1, BICD1, BICD2, APEX1, TBK1, GRIA1, PDPK1, GDA,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPS6KB1	chr17	57970680	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
RPS6KB1	chr17	57970694	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS6KB1	chr17	57991988	T	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS6KB1	BLCA	chr17	57990070	57990070	G	A	Missense_Mutation	p.E73K	4
RPS6KB1	LIHC	chr17	58013587	58013587	A	T	Missense_Mutation	p.R330S	4
RPS6KB1	LIHC	chr17	58022829	58022829	A	-	Frame_Shift_Del	p.P430fs	3
RPS6KB1	LIHC	chr17	58013587	58013587	A	T	Missense_Mutation		3
RPS6KB1	LUAD	chr17	57970609	57970609	G	A	Missense_Mutation	p.E22K	3
RPS6KB1	BRCA	chr17	58011559	58011559	A	G	Silent	p.L239	3
RPS6KB1	HNSC	chr17	58024140	58024140	G	C	Missense_Mutation	p.M523I	3
RPS6KB1	SKCM	chr17	58009056	58009056	C	T	Missense_Mutation	p.P221S	2
RPS6KB1	UCEC	chr17	57987951	57987951	G	A	Missense_Mutation	p.G57E	2
RPS6KB1	COAD	chr17	57970683	57970683	G	-	Frame_Shift_Del	p.E46fs	2
RPS6KB1	UCEC	chr17	57990134	57990134	T	G	Missense_Mutation	p.L94R	2
RPS6KB1	UCEC	chr17	58003778	58003778	T	G	Missense_Mutation	p.M128R	2
RPS6KB1	HNSC	chr17	58009058	58009058	G	A	Silent	p.P221P	2
RPS6KB1	UCEC	chr17	58003789	58003789	C	T	Missense_Mutation	p.P132S	2
RPS6KB1	UCEC	chr17	58011589	58011590	CA	-	Frame_Shift_Del	p.T252fs	2
RPS6KB1	STAD	chr17	58013600	58013600	C	T	Missense_Mutation	p.R335C	2
RPS6KB1	UCEC	chr17	58011822	58011822	C	T	Silent	p.G269	2
RPS6KB1	STAD	chr17	58024111	58024111	A	G	Missense_Mutation	p.I514V	2
RPS6KB1	UCEC	chr17	58013875	58013875	G	A	Silent	p.K364	2
RPS6KB1	BRCA	chr17	57987923	57987923	G	A	Missense_Mutation	p.G48S	2
RPS6KB1	STAD	chr17	58024086	58024086	A	T	Silent	p.P505P	2
RPS6KB1	UCEC	chr17	58024038	58024038	T	C	Silent	p.S489	2
RPS6KB1	BRCA	chr17	58013897	58013897	C	A	Missense_Mutation	p.L372M	2
RPS6KB1	SKCM	chr17	58009056	58009056	C	T	Missense_Mutation	p.P198S	2
RPS6KB1	BLCA	chr17	57990070	57990070	G	A	Missense_Mutation		2
RPS6KB1	LIHC	chr17	57990104	57990104	A	-	Frame_Shift_Del	p.E84fs	2
RPS6KB1	LUAD	chr17	58018242	58018242	C	G	Missense_Mutation	p.Q389E	2
RPS6KB1	CESC	chr17	58011881	58011881	G	A	Missense_Mutation		2
RPS6KB1	BLCA	chr17	58011538	58011538	G	A	Silent		1
RPS6KB1	LGG	chr17	58024066	58024066	C	T	Nonsense_Mutation	p.R499*	1
RPS6KB1	CESC	chr17	58011881	58011881	G	A	Missense_Mutation	p.G289E	1
RPS6KB1	LIHC	chr17	58013872	58013872	A	-	Frame_Shift_Del	p.R363fs	1
RPS6KB1	HNSC	chr17	57970560	57970560	G	A	Silent	p.R5R	1
RPS6KB1	LUAD	chr17	58024113	58024113	C	T	Silent	p.I514I	1
RPS6KB1	BLCA	chr17	58022809	58022809	G	T	Nonsense_Mutation	p.E424*	1
RPS6KB1	LGG	chr17	57990092	57990092	A	G	Missense_Mutation		1
RPS6KB1	SKCM	chr17	58024091	58024091	A	G	Missense_Mutation	p.K507R	1
RPS6KB1	HNSC	chr17	58013586	58013586	G	C	Missense_Mutation	p.R330T	1
RPS6KB1	LUSC	chr17	58024015	58024015	G	C	Missense_Mutation	p.E482Q	1
RPS6KB1	BLCA	chr17	58013630	58013630	G	T	Nonsense_Mutation	p.E345*	1
RPS6KB1	LIHC	chr17	57991997	57991997	T	C	Missense_Mutation		1
RPS6KB1	COAD	chr17	57990136	57990136	C	T	Missense_Mutation	p.R95W	1
RPS6KB1	LIHC	chr17	58012593	58012593	A	-	Frame_Shift_Del	p.K304fs	1
RPS6KB1	SKCM	chr17	58022834	58022834	T	C	Missense_Mutation	p.I432T	1
RPS6KB1	MESO	chr17	58011570	58011570	C	A	Missense_Mutation		1
RPS6KB1	BLCA	chr17	58013871	58013871	G	A	Missense_Mutation	p.R363Q	1
RPS6KB1	LIHC	chr17	57970637	57970637	A	G	Missense_Mutation		1
RPS6KB1	COAD	chr17	58011614	58011614	G	T	Nonsense_Mutation	p.E258X	1
RPS6KB1	LIHC	chr17	57992010	57992010	A	-	Frame_Shift_Del	p.R109fs	1
RPS6KB1	SKCM	chr17	58012624	58012624	C	T	Missense_Mutation	p.P314L	1
RPS6KB1	HNSC	chr17	57970583	57970583	C	-	Frame_Shift_Del	p.A13fs	1
RPS6KB1	OV	chr17	55325462	55325462	G	A	Silent	p.E45	1
RPS6KB1	SARC	chr17	58003814	58003814	G	T	Missense_Mutation		1
RPS6KB1	BLCA	chr17	58003876	58003876	C	T	Silent	p.F154F	1
RPS6KB1	ESCA	chr17	58012585	58012585	C	A	Missense_Mutation		1
RPS6KB1	LIHC	chr17	58013882	58013882	C	-	Frame_Shift_Del	p.P368fs	1
RPS6KB1	STAD	chr17	58024089	58024090	-	A	Frame_Shift_Ins	p.Y506fs	1
RPS6KB1	KIRC	chr17	58007518	58007518	T	C	Silent	p.F190F	1
RPS6KB1	SARC	chr17	58009077	58009077	C	A	Missense_Mutation		1
RPS6KB1	LIHC	chr17	57987942	57987942	T	C	Translation_Start_Site		1
RPS6KB1	ESCA	chr17	57990061	57990061	G	T	Nonsense_Mutation	p.E70X	1
RPS6KB1	LIHC	chr17	58023922	58023922	T	-	Frame_Shift_Del	p.F451fs	1
RPS6KB1	KIRC	chr17	58022845	58022845	C	T	Nonsense_Mutation	p.R436X	1
RPS6KB1	SARC	chr17	58012599	58012599	C	A	Missense_Mutation		1
RPS6KB1	BLCA	chr17	57990079	57990079	G	C	Missense_Mutation	p.E76Q	1
RPS6KB1	ESCA	chr17	57970680	57970680	G	A	Silent	p.E45E	1
RPS6KB1	LIHC	chr17	58023941	58023941	G	-	Frame_Shift_Del	p.W457fs	1
RPS6KB1	BLCA	chr17	58003876	58003876	C	T	Silent		1
RPS6KB1	KIRC	chr17	58022845	58022845	C	A	Silent	p.R436R	1
RPS6KB1	LIHC	chr17	57970637	57970637	A	G	Missense_Mutation	p.D31G	1
RPS6KB1	SARC	chr17	58024071	58024071	G	T	Missense_Mutation		1
RPS6KB1	HNSC	chr17	58013586	58013586	G	C	Missense_Mutation		1
RPS6KB1	LUAD	chr17	57992021	57992021	G	C	Missense_Mutation	p.G113A	1
RPS6KB1	BLCA	chr17	58013871	58013871	G	A	Missense_Mutation		1
RPS6KB1	KIRC	chr17	58012656	58012656	A	-	Frame_Shift_Del	p.K326fs	1
RPS6KB1	LIHC	chr17	58013587	58013587	A	-	Frame_Shift_Del	p.R330fs	1
RPS6KB1	HNSC	chr17	58009058	58009058	G	A	Silent		1
RPS6KB1	STAD	chr17	58024090	58024091	-	A	Frame_Shift_Ins	p.Y506fs	1
RPS6KB1	LGG	chr17	57990092	57990092	A	G	Missense_Mutation	p.N80S	1
RPS6KB1	SKCM	chr17	58022834	58022834	T	C	Missense_Mutation	p.I379T	1
RPS6KB1	HNSC	chr17	58024140	58024140	G	C	Missense_Mutation		1
RPS6KB1	UCEC	chr17	58024038	58024038	T	C	Silent	p.S489S	1
RPS6KB1	BLCA	chr17	57990079	57990079	G	C	Missense_Mutation		1
RPS6KB1	LGG	chr17	58018248	58018248	C	T	Missense_Mutation	p.P391S	1
RPS6KB1	LIHC	chr17	58007516	58007516	T	-	Frame_Shift_Del	p.F190fs	1
RPS6KB1	SKCM	chr17	58024091	58024091	A	G	Missense_Mutation	p.K484R	1
RPS6KB1	UCEC	chr17	58011589	58011590	CA	-	Frame_Shift_Del	p.V249fs	1
RPS6KB1	LUAD	chr17	58011874	58011874	C	T	Silent	p.L287L	1

Copy number variation (CNV) of RPS6KB1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS6KB1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
98214	N/A	AV698075	AMBP	chr9	116822407	-	RPS6KB1	chr17	57978987	+
98214	CESC	TCGA-C5-A907-01A	BCAS3	chr17	58755275	+	RPS6KB1	chr17	57990045	+
98214	BRCA	TCGA-EW-A1PB-01A	C1orf132	chr1	208041271	-	RPS6KB1	chr17	57987923	+
98214	BRCA	TCGA-AC-A62V-01A	CLTC	chr17	57746301	+	RPS6KB1	chr17	57987923	+
98214	BRCA	TCGA-A1-A0SN	DDX42	chr17	61882535	+	RPS6KB1	chr17	57987922	+
98214	BRCA	TCGA-A1-A0SN-01A	DDX42	chr17	61882534	+	RPS6KB1	chr17	57987922	+
98214	BRCA	TCGA-A1-A0SN-01A	DDX42	chr17	61882535	+	RPS6KB1	chr17	57987923	+
98214	BRCA	TCGA-A1-A0SN-01A	DDX42	chr17	61882815	+	RPS6KB1	chr17	57989481	+
98214	HNSC	TCGA-MZ-A6I9-01A	HSD17B12	chr11	43861614	+	RPS6KB1	chr17	57987923	+
98214	N/A	BC012551	IBTK	chr6	82927682	-	RPS6KB1	chr17	57978983	+
98214	LIHC	TCGA-DD-AADC-01A	PRKCA	chr17	64683385	+	RPS6KB1	chr17	57987923	+
103240	KIRC	TCGA-BP-5198-01A	RPS6KB1	chr17	57970686	+	CLTC	chr17	57762417	+
88939	BRCA	TCGA-AN-A0FD-01A	RPS6KB1	chr17	57970686	+	EFCAB3	chr17	60460324	+
78045	BRCA	TCGA-AC-A8OP-01A	RPS6KB1	chr17	58003943	+	EVPLL	chr17	18278822	+
78045	LUSC	TCGA-85-8580-01A	RPS6KB1	chr17	57970686	-	FKBP10	chr17	39974341	+
78045	N/A	AA362032	RPS6KB1	chr17	57990167	+	HTR2C	chrX	113934208	-
97359	BRCA	TCGA-A2-A1FW-01A	RPS6KB1	chr17	58022879	+	MAP3K3	chr17	61723394	+
98765	GBM	TCGA-06-2570-01A	RPS6KB1	chr17	58013902	+	NPLOC4	chr17	79526442	-
99596	BRCA	TCGA-AQ-A04H	RPS6KB1	chr17	57970686	+	RNF213	chr17	78345673	+
99596	BRCA	TCGA-AQ-A04H-01B	RPS6KB1	chr17	57970686	+	RNF213	chr17	78345674	+
99596	BRCA	TCGA-AQ-A04H-01B	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
98212	CESC	TCGA-C5-A907-01A	RPS6KB1	chr17	57992063	+	RNFT1	chr17	58030406	-
98212	CESC	TCGA-C5-A907-01A	RPS6KB1	chr17	57992064	+	RNFT1	chr17	58030407	-
94826	N/A	XX000001	RPS6KB1	chr17	57970687	+	SNF8	chr17	47021338	-
101636	ESCA	TCGA-VR-A8Q7	RPS6KB1	chr17	57992064	+	TAOK1	chr17	27822578	+
96860	BRCA	TCGA-A1-A0SN-01A	RPS6KB1	chr17	57990164	+	TEX2	chr17	62291601	-
96860	BRCA	TCGA-A1-A0SN-01A	RPS6KB1	chr17	57990165	+	TEX2	chr17	62291602	-
99293	BRCA	TCGA-C8-A273-01A	RPS6KB1	chr17	57970686	+	TUBD1	chr17	57944110	-
99293	BRCA	TCGA-C8-A273-01A	RPS6KB1	chr17	57970686	+	TUBD1	chr17	57955695	-
97902	BLCA	TCGA-4Z-AA7Q	RPS6KB1	chr17	57992064	+	VMP1	chr17	57917128	+
97902	BLCA	TCGA-4Z-AA7Q	RPS6KB1	chr17	57992064	+	VMP1	chr17	57917129	+
97902	BLCA	TCGA-DK-A2I4-01A	RPS6KB1	chr17	57970686	+	VMP1	chr17	57915656	+
97902	BLCA	TCGA-HQ-A2OE-01A	RPS6KB1	chr17	57970686	+	VMP1	chr17	57886157	+
97902	BLCA	TCGA-PQ-A6FI-01A	RPS6KB1	chr17	57992064	+	VMP1	chr17	57915656	+
97902	BRCA	TCGA-A8-A09I	RPS6KB1	chr17	57970686	+	VMP1	chr17	57886156	+
97902	BRCA	TCGA-AC-A2BK	RPS6KB1	chr17	57987972	+	VMP1	chr17	57886156	+
97902	BRCA	TCGA-AC-A2BK-01A	RPS6KB1	chr17	57987972	+	VMP1	chr17	57886157	+
97902	BRCA	TCGA-BH-A0B9	RPS6KB1	chr17	57992064	+	VMP1	chr17	57915655	+
97902	BRCA	TCGA-D8-A27H	RPS6KB1	chr17	57970686	+	VMP1	chr17	57842331	+
97902	BRCA	TCGA-D8-A27H-01A	RPS6KB1	chr17	57970686	+	VMP1	chr17	57842332	+
97902	BRCA	TCGA-JL-A3YW	RPS6KB1	chr17	57970686	+	VMP1	chr17	57915655	+
97902	BRCA	TCGA-JL-A3YW-01A	RPS6KB1	chr17	57970685	+	VMP1	chr17	57915655	+
97902	CESC	TCGA-C5-A7X5-01A	RPS6KB1	chr17	58009083	+	VMP1	chr17	57895073	+
97902	ESCA	TCGA-LN-A4A8	RPS6KB1	chr17	57992064	+	VMP1	chr17	57808781	+
97902	ESCA	TCGA-LN-A4A8	RPS6KB1	chr17	57992064	+	VMP1	chr17	57808782	+
97902	HNSC	TCGA-BA-6868	RPS6KB1	chr17	57990165	+	VMP1	chr17	57915655	+
97902	HNSC	TCGA-BA-6868	RPS6KB1	chr17	57990165	+	VMP1	chr17	57915656	+
97902	HNSC	TCGA-CR-7369	RPS6KB1	chr17	57971285	+	VMP1	chr17	57915656	+
97902	HNSC	TCGA-P3-A6T4	RPS6KB1	chr17	57990165	+	VMP1	chr17	57886157	+
97902	LUAD	TCGA-49-AAQV	RPS6KB1	chr17	58013902	+	VMP1	chr17	57915656	+
97902	LUAD	TCGA-50-6592	RPS6KB1	chr17	58007535	+	VMP1	chr17	57915655	+
97902	LUAD	TCGA-50-6592-01A	RPS6KB1	chr17	58007535	+	VMP1	chr17	57915656	+
97902	LUAD	TCGA-55-A490	RPS6KB1	chr17	58012661	+	VMP1	chr17	57886157	+
97902	LUAD	TCGA-69-7978	RPS6KB1	chr17	57992064	+	VMP1	chr17	57886156	+
97902	LUAD	TCGA-69-7978-01A	RPS6KB1	chr17	57970686	+	VMP1	chr17	57814814	+
97902	LUAD	TCGA-69-7978-01A	RPS6KB1	chr17	57992064	+	VMP1	chr17	57886157	+
97902	LUAD	TCGA-86-7711	RPS6KB1	chr17	58003943	+	VMP1	chr17	57917128	+
97902	LUAD	TCGA-86-7711-01A	RPS6KB1	chr17	58003943	+	VMP1	chr17	57917129	+
97902	LUAD	TCGA-93-A4JQ	RPS6KB1	chr17	57992064	+	VMP1	chr17	57842331	+
97902	LUAD	TCGA-93-A4JQ-01A	RPS6KB1	chr17	57992063	+	VMP1	chr17	57842331	+
97902	LUAD	TCGA-93-A4JQ-01A	RPS6KB1	chr17	57992064	+	VMP1	chr17	57842332	+
97902	LUSC	TCGA-94-8035	RPS6KB1	chr17	57992064	+	VMP1	chr17	57889031	+
97902	OV	TCGA-24-2280	RPS6KB1	chr17	57970686	+	VMP1	chr17	57889030	+
97902	OV	TCGA-24-2280-01A	RPS6KB1	chr17	57970686	+	VMP1	chr17	57889031	+
97902	STAD	TCGA-D7-6519	RPS6KB1	chr17	57970686	+	VMP1	chr17	57917128	+
97902	UCEC	TCGA-EY-A1GS-01A	RPS6KB1	chr17	57992064	+	VMP1	chr17	57851115	+
97902	.	.	RPS6KB1	chr17	57987922	+	VMP1	chr17	57987922	+
98214	LUAD	TCGA-69-7978-01A	TUBD1	chr17	57970058	-	RPS6KB1	chr17	57987923	+
98224	BLCA	TCGA-FD-A3B7-01A	VMP1	chr17	57785109	+	RPS6KB1	chr17	57987923	+
98224	BLCA	TCGA-G2-AA3B	VMP1	chr17	57915758	+	RPS6KB1	chr17	57987922	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	RPS6KB1	0.00169288505543331	0.046
SARC	RPS6KB1	0.0212128683787312	0.55
BRCA	RPS6KB1	1.44434796435499e-05	4e-04

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPS6KB1	0.0428928748227244	1
KIRP	RPS6KB1	0.00105503136225776	0.035
LAML	RPS6KB1	0.0281383256617968	0.87
THYM	RPS6KB1	0.0136015548230183	0.44

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0079744	Diffuse Large B-Cell Lymphoma	1	CTD_human
C0149721	Left Ventricular Hypertrophy	1	CTD_human
C2931673	Ceroid lipofuscinosis, neuronal 1, infantile	1	CTD_human