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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS7 (NCBI Gene ID:6201)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS7
	Gene ID: 6201
	Gene Symbol	RPS7
	Gene ID	6201
	Gene Name	ribosomal protein S7
	Synonyms	DBA8\|S7\|eS7
	Cytomap	2p25.3
	Type of Gene	protein-coding
	Description	40S ribosomal protein S7small ribosomal subunit protein eS7
	Modification date	20200313
	UniProtAcc	P62081

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS7	GO:1904667	negative regulation of ubiquitin protein ligase activity	17310983
Hgene	RPS7	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	17310983

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS7	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS7[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS7	Molecular network including eIF1AX, RPS7, and 14-3-3γ regulates protein translation and cell proliferation in bovine mammary epithelial cells	25281768

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000304921	3623406	3623478	In-frame
ENST00000403564	3623406	3623478	In-frame
ENST00000406376	3623406	3623478	In-frame
ENST00000304921	3625299	3625364	Frame-shift
ENST00000403564	3625299	3625364	Frame-shift
ENST00000406376	3625299	3625364	Frame-shift
ENST00000304921	3627699	3627850	Frame-shift
ENST00000403564	3627699	3627850	Frame-shift
ENST00000406376	3627699	3627850	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000406376	3623406	3623478	721	176	247	194	25	49
ENST00000403564	3623406	3623478	781	218	289	194	25	49
ENST00000304921	3623406	3623478	803	240	311	194	25	49

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P62081	25	49	1	194	Chain	ID=PRO_0000174190;Note=40S ribosomal protein S7
P62081	25	49	1	194	Chain	ID=PRO_0000174190;Note=40S ribosomal protein S7
P62081	25	49	1	194	Chain	ID=PRO_0000174190;Note=40S ribosomal protein S7

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRP	RPS7	-3.08161607224061	0.000256400555372238
PRAD	RPS7	2.19690532093525	0.00482349779780149
KICH	RPS7	2.35513673345303	0.00672554969787598
COAD	RPS7	1.80899366786773	5.1647424697876e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LUAD	RPS7	0.089358293	0.009470498
LGG	RPS7	-0.045323267	0.009855111
HNSC	RPS7	-0.052841802	0.010607461
LIHC	RPS7	0.042653301	0.015156345
KIRC	RPS7	-0.032910553	0.015740193

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS7 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	TSG	RPS7	GNB2L1	0.81736166	7.38E-12
DLBC	Cell metabolism gene	RPS7	FAU	0.824821572	5.70E-13
DLBC	CGC	RPS7	NACA	0.836856805	1.27E-13
DLBC	TSG	RPS7	GNB2L1	0.850329701	2.04E-14
GBM	Cell metabolism gene	RPS7	LSM1	0.80422797	2.90E-40
GBM	Cell metabolism gene	RPS7	SUCLG1	0.809661536	3.40E-41
GBM	Cell metabolism gene	RPS7	DGUOK	0.814045252	5.74E-42
GBM	Cell metabolism gene	RPS7	PSMB4	0.81852185	8.87E-43
GBM	Cell metabolism gene	RPS7	PSMA5	0.825581479	4.19E-44
GBM	Cell metabolism gene	RPS7	SNRPG	0.834372019	7.70E-46
GBM	Cell metabolism gene	RPS7	CCT4	0.841467439	2.56E-47
GBM	Cell metabolism gene	RPS7	PFDN5	0.844101942	6.95E-48
GBM	Cell metabolism gene	RPS7	FAU	0.848239549	8.50E-49
GBM	TSG	RPS7	GAS5	0.833618128	1.09E-45
KICH	Cell metabolism gene	RPS7	SSR2	0.805073889	6.77E-22
KICH	Cell metabolism gene	RPS7	SNRPG	0.808442704	3.37E-22
LGG	Cell metabolism gene	RPS7	FAU	0.812558941	7.17E-126
LIHC	CGC	RPS7	NACA	0.818456004	2.29E-103
PRAD	Cell metabolism gene	RPS7	TIMM9	0.81369569	3.23E-131
PRAD	CGC	RPS7	NACA	0.872529711	1.31E-172
PRAD	TSG	RPS7	GAS5	0.827232776	2.57E-139
PRAD	TSG	RPS7	GNB2L1	0.86247025	3.32E-164
THCA	Cell metabolism gene	RPS7	SNRPD2	0.807162069	1.38E-132
THCA	Cell metabolism gene	RPS7	PFDN5	0.826901008	1.28E-144
THCA	Cell metabolism gene	RPS7	FAU	0.867111442	1.16E-174
THCA	TSG	RPS7	GNB2L1	0.800968127	4.28E-129
THYM	Cell metabolism gene	RPS7	PGLS	0.801902604	1.29E-28
THYM	Cell metabolism gene	RPS7	PSMB3	0.802882225	9.92E-29
THYM	Cell metabolism gene	RPS7	ACOT8	0.8030155	9.56E-29
THYM	Cell metabolism gene	RPS7	SNRPF	0.805613073	4.69E-29
THYM	Cell metabolism gene	RPS7	ITPA	0.805802314	4.45E-29
THYM	Cell metabolism gene	RPS7	APRT	0.80755625	2.73E-29
THYM	Cell metabolism gene	RPS7	PFDN6	0.80907822	1.78E-29
THYM	Cell metabolism gene	RPS7	POLR2F	0.812838869	6.08E-30
THYM	Cell metabolism gene	RPS7	DPM2	0.813282339	5.35E-30
THYM	Cell metabolism gene	RPS7	PSMD13	0.814241084	4.05E-30
THYM	Cell metabolism gene	RPS7	PSMC3	0.819290803	9.10E-31
THYM	Cell metabolism gene	RPS7	LSM2	0.820406465	6.50E-31
THYM	Cell metabolism gene	RPS7	TIMM13	0.821027352	5.39E-31
THYM	Cell metabolism gene	RPS7	SSR2	0.826548037	9.80E-32
THYM	Cell metabolism gene	RPS7	PSMB7	0.840165604	1.11E-33
THYM	Cell metabolism gene	RPS7	SNRPD3	0.848030038	6.91E-35
THYM	Cell metabolism gene	RPS7	SLC27A5	0.854115963	7.20E-36
THYM	Cell metabolism gene	RPS7	SNRPD2	0.865195189	8.89E-38
THYM	Cell metabolism gene	RPS7	PFDN5	0.865361443	8.30E-38
THYM	Cell metabolism gene	RPS7	TIMM8B	0.867581166	3.28E-38
THYM	Cell metabolism gene	RPS7	FAU	0.909975439	1.06E-47
THYM	Epifactor	RPS7	BRMS1	0.803356919	8.71E-29
THYM	Epifactor	RPS7	ZNHIT1	0.808465876	2.11E-29
THYM	Epifactor	RPS7	INO80E	0.811067871	1.01E-29
THYM	Epifactor	RPS7	RUVBL2	0.811264348	9.56E-30
THYM	Epifactor	RPS7	SS18L2	0.821795078	4.27E-31
THYM	Epifactor	RPS7	SIRT6	0.832364923	1.52E-32
THYM	Epifactor	RPS7	TAF10	0.83722584	3.03E-33
THYM	Epifactor	RPS7	FBL	0.853669165	8.53E-36
THYM	IUPHAR	RPS7	PPIA	0.802282591	1.17E-28
THYM	IUPHAR	RPS7	SIRT6	0.832364923	1.52E-32
THYM	IUPHAR	RPS7	SLC27A5	0.854115963	7.20E-36
THYM	TF	RPS7	ZNF787	0.801609931	1.40E-28
THYM	TF	RPS7	ZNF32	0.807102848	3.10E-29
THYM	TF	RPS7	THAP3	0.8165761	2.04E-30
THYM	TF	RPS7	ZNF428	0.836007474	4.57E-33
THYM	TSG	RPS7	BRMS1	0.803356919	8.71E-29
THYM	TSG	RPS7	PARK7	0.804178304	6.96E-29
THYM	TSG	RPS7	HTRA2	0.805439079	4.92E-29
THYM	TSG	RPS7	GADD45GIP1	0.812712716	6.31E-30
THYM	TSG	RPS7	NPRL2	0.820008807	7.33E-31
THYM	TSG	RPS7	GLTSCR2	0.825898329	1.20E-31
THYM	TSG	RPS7	SIRT6	0.832364923	1.52E-32
THYM	TSG	RPS7	GNB2L1	0.896178959	3.61E-44
UCS	Cell metabolism gene	RPS7	PGLS	0.801902604	1.29E-28
UCS	Cell metabolism gene	RPS7	PSMB3	0.802882225	9.92E-29
UCS	Cell metabolism gene	RPS7	ACOT8	0.8030155	9.56E-29
UCS	Cell metabolism gene	RPS7	SNRPF	0.805613073	4.69E-29
UCS	Cell metabolism gene	RPS7	ITPA	0.805802314	4.45E-29
UCS	Cell metabolism gene	RPS7	APRT	0.80755625	2.73E-29
UCS	Cell metabolism gene	RPS7	PFDN6	0.80907822	1.78E-29
UCS	Cell metabolism gene	RPS7	POLR2F	0.812838869	6.08E-30
UCS	Cell metabolism gene	RPS7	DPM2	0.813282339	5.35E-30
UCS	Cell metabolism gene	RPS7	PSMD13	0.814241084	4.05E-30
UCS	Cell metabolism gene	RPS7	PSMC3	0.819290803	9.10E-31
UCS	Cell metabolism gene	RPS7	LSM2	0.820406465	6.50E-31
UCS	Cell metabolism gene	RPS7	TIMM13	0.821027352	5.39E-31
UCS	Cell metabolism gene	RPS7	SSR2	0.826548037	9.80E-32
UCS	Cell metabolism gene	RPS7	PSMB7	0.840165604	1.11E-33
UCS	Cell metabolism gene	RPS7	SNRPD3	0.848030038	6.91E-35
UCS	Cell metabolism gene	RPS7	SLC27A5	0.854115963	7.20E-36
UCS	Cell metabolism gene	RPS7	SNRPD2	0.865195189	8.89E-38
UCS	Cell metabolism gene	RPS7	PFDN5	0.865361443	8.30E-38
UCS	Cell metabolism gene	RPS7	TIMM8B	0.867581166	3.28E-38
UCS	Cell metabolism gene	RPS7	FAU	0.909975439	1.06E-47
UCS	Epifactor	RPS7	BRMS1	0.803356919	8.71E-29
UCS	Epifactor	RPS7	ZNHIT1	0.808465876	2.11E-29
UCS	Epifactor	RPS7	INO80E	0.811067871	1.01E-29
UCS	Epifactor	RPS7	RUVBL2	0.811264348	9.56E-30
UCS	Epifactor	RPS7	SS18L2	0.821795078	4.27E-31
UCS	Epifactor	RPS7	SIRT6	0.832364923	1.52E-32
UCS	Epifactor	RPS7	TAF10	0.83722584	3.03E-33
UCS	Epifactor	RPS7	FBL	0.853669165	8.53E-36
UCS	IUPHAR	RPS7	PPIA	0.802282591	1.17E-28
UCS	IUPHAR	RPS7	SIRT6	0.832364923	1.52E-32
UCS	IUPHAR	RPS7	SLC27A5	0.854115963	7.20E-36
UCS	TF	RPS7	ZNF787	0.801609931	1.40E-28
UCS	TF	RPS7	ZNF32	0.807102848	3.10E-29
UCS	TF	RPS7	THAP3	0.8165761	2.04E-30
UCS	TF	RPS7	ZNF428	0.836007474	4.57E-33
UCS	TSG	RPS7	BRMS1	0.803356919	8.71E-29
UCS	TSG	RPS7	PARK7	0.804178304	6.96E-29
UCS	TSG	RPS7	HTRA2	0.805439079	4.92E-29
UCS	TSG	RPS7	GADD45GIP1	0.812712716	6.31E-30
UCS	TSG	RPS7	NPRL2	0.820008807	7.33E-31
UCS	TSG	RPS7	GLTSCR2	0.825898329	1.20E-31
UCS	TSG	RPS7	SIRT6	0.832364923	1.52E-32
UCS	TSG	RPS7	GNB2L1	0.896178959	3.61E-44
UVM	Cell metabolism gene	RPS7	TIMM9	0.819020432	1.66E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS7	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS7	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS7	RPS16	-1.35957043617517	0.00019507110118866
STAD	RPS7	RPS23	1.85076760664576	0.000364991836249828
COAD	RPS7	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS7	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS7	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS7	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS7	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS7	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS7	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS7	RPS16	-6.16322798156577	0.0115764821363307
LUSC	RPS7	RPS23	1.46751169891047	0.0174932185880974
BLCA	RPS7	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS7	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS7	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS7	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS7	RPL19	-2.14669889516666	0.044366810398747
UCEC	RPS7	RPS23	-2.03658159814007	0.046875
KIRC	RPS7	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS7	RPS12	-4.91239327478244	1.85340619742495e-09
KIRC	RPS7	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS7	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS7	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS7	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS7	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRP	RPS7	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS7	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS7	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS7

SRRM2, SRRM1, TERF1, POT1, MDM2, TP53, RAD21, ARRB2, SIRT7, CUL3, CUL4B, CUL5, CDK2, CUL1, COPS5, CAND1, PIK3R2, RPS4X, RPL15, RPL18A, RPL18, RPL19, RPL31, RPL37A, RPL5, RPL6, RPL7, RPS13, RPS14, RPS15A, RPS15, RPS23, RPS2, RPS3, RPS6, RPS24, RPLP2, RPS5, RPS8, RPS11, RPL30, RPLP1, RPL11, RPL23A, RPL4, RPL23, RPL3, RPSA, RPS10, RPL13, RPL35, RPS16, RPS17, RPS9, RPL10, RPS19, RPL14, RPS25, EEF2, RPS21, NOP56, NOP58, GNL3, FBL, RSL1D1, NHP2L1, U2AF1, HNRNPM, HNRNPA2B1, DDB1, RPLP0P6, NOP2, RRS1, NCSTN, ABCC1, LAMTOR3, BOP1, PTBP1, BUD31, IK, SNRPD1, HNRNPK, HNRNPDL, CYB5R3, RPL10L, DDX39B, FN1, VCAM1, UBL4A, ITGA4, GADD45A, PAN2, NEK6, UPF2, FBXO6, TARDBP, PNO1, PSMC4, RPS12, RPS20, RPS26, RPS27L, RPS27, RPS28, DDX3X, EIF2A, FAU, RPS18, RPS29, RPS3A, WDR26, TSR1, WIBG, RPA1, RPA2, RPA3, CDC37L1, CEP57, CEP76, TUBGCP3, HUWE1, ZBTB14, BRCA1, EED, RNF2, LUZP4, SPINT2, HNRNPA1, RPS6KB2, DDX23, NOL6, RPL10A, RPL12, LOC101929876, BRIX1, DDX18, DDX24, ETF1, KRR1, MPHOSPH10, NOC4L, RPL13A, RPL21, RPL22, RPL24, RPL27, RPL27A, RPL36, RPL38, RPL7A, RPL8, RPL9, RPLP0, RRP7A, UTP20, XRN1, UBA52, XPO1, HIST1H3E, AHSA1, HNRNPU, VIM, EXOSC5, Eif3e, Srp72, MCM2, NF2, Mdm2, POU5F1, RC3H1, PPEF2, RPL36AL, TRIM26, RPL26L1, JMJD6, NPM1, NCL, CYLD, TRIM25, HEY1, LMNA, MTF1, HDAC6, TRIM14, APOE, YAP1, BMP4, PPIE, YAF2, UBE2M, PRPF8, AAR2, PIH1D1, EFTUD2, RNF4, CHD3, CHD4, LARP7, RIOK1, FGF11, HEXIM1, MEPCE, SNAI1, AGR2, RECQL4, DCPS, WWP1, REST, ZFP36L2, MYC, CDK9, HIST1H2AB, METTL14, KIAA1429, EIF4B, DCAF13, RC3H2, ACTC1, PHB, RBX1, DISC1, NR2C2, PPP1CC, PRDM16, MECOM, PRMT7, DYNC1LI1, DYNC1LI2, VRK1, VRK3, HIST1H4A, SNRNP70, ITFG1, GHET1, ARAF, BIRC3, NFX1, WWP2, CMTR1, PLEKHA4, PINK1, TFCP2, FANCD2, NGB, HCVgp1, ZC3H18, KXD1, TCF20, M, nsp4, nsp5, nsp6, ORF3a, ORF6, ORF7a, ORF7b, DUX4, CIT, ANLN, AURKB, CHMP4B, ECT2, KIF14, MAD2L2, KIF23, PRC1, LRRC59, INS, NDN, HULC, BRD4, RBM45, CIC, Apc2, RBM39, LGALS9, RIN3, OGT, AR, PARK2, UFL1, DDRGK1, TRIM37, ATG10, UBQLN1, FZR1, WDR5, NUDCD2, ZBTB2, FGFBP1, BTF3, FBXW7, HOOK1, EIF4ENIF1, NLRP7, RCHY1, CCNF, SQSTM1, N,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPS7	chr2	3622662	G	T	single_nucleotide_variant	Benign	not_provided
RPS7	chr2	3622850	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS7	chr2	3622855	G	A	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS7	chr2	3622873	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS7	chr2	3622912	G	T	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_8\|not_specified	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS7	chr2	3622915	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS7	chr2	3622923	A	C	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_8	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS7	chr2	3622932	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS7	chr2	3622936	G	A	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS7	chr2	3622941	G	A	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_8	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RPS7	chr2	3622941	G	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RPS7	chr2	3622953	C	T	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_8	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3623187	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS7	chr2	3623197	G	A	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS7	chr2	3623210	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS7	chr2	3623233	A	C	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS7	chr2	3623234	A	G	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS7	chr2	3623238	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_8	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS7	chr2	3623275	G	A	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_8	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RPS7	chr2	3623287	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_8	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3623404	T	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3623406	G	T	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_8	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
RPS7	chr2	3623430	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS7	chr2	3623433	G	A	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_8	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS7	chr2	3623444	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS7	chr2	3623464	A	G	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS7	chr2	3623468	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS7	chr2	3623479	G	A	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_8	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RPS7	chr2	3623486	G	A	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_8	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3623540	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3623541	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3623555	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3623620	T	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3623883	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3623939	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3623998	G	A	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3624051	C	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3624086	G	A	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS7	chr2	3624145	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS7	chr2	3624202	T	C	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_8	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS7	chr2	3624202	TGTC	T	Microsatellite	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
RPS7	chr2	3624205	C	G	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_8	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS7	chr2	3624214	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_8	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS7	chr2	3624221	G	GT	Duplication	Uncertain_significance	not_provided	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RPS7	chr2	3624303	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3625038	G	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3625067	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3625147	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3625175	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3625179	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3625261	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3625279	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3625291	A	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_8	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3625367	G	A	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3625393	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3625429	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3627648	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3627690	A	G	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_8	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3627693	C	CT	Duplication	Benign	Diamond-Blackfan_anemia_8\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3627693	CT	C	Deletion	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3627721	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_8	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS7	chr2	3627749	C	G	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS7	chr2	3627776	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS7	chr2	3627778	C	T	single_nucleotide_variant	Benign/Likely_benign	Diamond-Blackfan_anemia_8	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS7	chr2	3628198	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3628383	C	A	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_8\|not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3628392	T	G	single_nucleotide_variant	Likely_pathogenic	Diamond-Blackfan_anemia_8	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS7	chr2	3628405	T	C	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS7	chr2	3628406	T	A	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS7	chr2	3628406	T	C	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_8	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS7	chr2	3628407	T	G	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS7	chr2	3628415	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS7	chr2	3628426	T	A	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS7	chr2	3628430	G	A	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_8	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS7	chr2	3628467	T	C	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_8	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS7	chr2	3628503	C	T	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_8	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
RPS7	chr2	3628583	G	C	single_nucleotide_variant	Likely_benign	not_provided
RPS7	chr2	3628679	G	A	single_nucleotide_variant	Likely_benign	not_provided

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS7	UCEC	chr2	3627755	3627755	G	A	Missense_Mutation	p.E138K	4
RPS7	UCEC	chr2	3623448	3623448	G	T	Missense_Mutation	p.Q39H	3
RPS7	UCS	chr2	3628443	3628443	A	G	Missense_Mutation	p.N186D	3
RPS7	STAD	chr2	3627805	3627805	A	T	Silent	p.I154I	2
RPS7	STAD	chr2	3625326	3625326	A	-	Frame_Shift_Del	p.R106fs	2
RPS7	SARC	chr2	3624141	3624141	C	G	Missense_Mutation	p.S71C	2
RPS7	SKCM	chr2	3627805	3627805	A	G	Missense_Mutation	p.I154M	2
RPS7	BLCA	chr2	3627748	3627748	C	T	Silent	p.F135F	2
RPS7	GBM	chr2	3625334	3625334	G	A	Missense_Mutation		2
RPS7	SKCM	chr2	3628410	3628410	G	A	Missense_Mutation	p.G175S	2
RPS7	BLCA	chr2	3623453	3623453	G	A	Missense_Mutation	p.R41K	2
RPS7	BLCA	chr2	3627712	3627712	A	T	Silent	p.T123T	2
RPS7	UCEC	chr2	3623180	3623180	A	G	Splice_Site	e1-2	2
RPS7	CESC	chr2	3623406	3623406	G	T	Splice_Site		2
RPS7	UCEC	chr2	3627792	3627792	G	A	Missense_Mutation	p.G150D	2
RPS7	STAD	chr2	3628430	3628430	G	A	Silent	p.T181T	2
RPS7	LUAD	chr2	3627799	3627799	G	C	Silent	p.R152R	2
RPS7	BLCA	chr2	3627748	3627748	C	T	Silent		1
RPS7	CESC	chr2	3623257	3623257	G	C	Missense_Mutation		1
RPS7	LUAD	chr2	3623248	3623248	G	T	Missense_Mutation	p.D17Y	1
RPS7	BLCA	chr2	3623453	3623453	G	A	Missense_Mutation		1
RPS7	CESC	chr2	3623257	3623257	G	C	Missense_Mutation	p.E20Q	1
RPS7	SARC	chr2	3624141	3624141	C	G	Missense_Mutation		1
RPS7	BLCA	chr2	3627712	3627712	A	T	Silent		1
RPS7	STAD	chr2	3627819	3627819	A	C	Missense_Mutation	p.D159A	1
RPS7	COAD	chr2	3624214	3624214	C	T	Silent	p.I95I	1
RPS7	BLCA	chr2	3628398	3628398	G	A	Missense_Mutation		1
RPS7	TGCT	chr2	3627893	3627894	GA	-	Frame_Shift_Del		1
RPS7	COAD	chr2	3627776	3627776	C	T	Missense_Mutation	p.R145C	1
RPS7	TGCT	chr2	3627893	3627894	GA	-	Frame_Shift_Del	p.E184fs	1
RPS7	LGG	chr2	3623241	3623241	G	A	Silent	p.E14E	1
RPS7	SKCM	chr2	3628396	3628396	T	C	Splice_Site	p.V170_splice	1
RPS7	LGG	chr2	3623248	3623248	G	A	Missense_Mutation	p.D17N	1
RPS7	SKCM	chr2	3624207	3624207	T	C	Missense_Mutation	p.V93A	1
RPS7	BLCA	chr2	3628398	3628398	G	A	Missense_Mutation	p.E171K	1
RPS7	LIHC	chr2	3624107	3624107	A	G	Missense_Mutation	p.I60V	1
RPS7	SKCM	chr2	3624082	3624082	T	A	Silent	p.I51I	1
RPS7	LIHC	chr2	3627848	3627848	A	-	Frame_Shift_Del	p.K169fs	1
RPS7	SKCM	chr2	3628456	3628456	C	A	Missense_Mutation	p.P190Q	1
RPS7	CESC	chr2	3623422	3623422	G	C	Missense_Mutation		1
RPS7	LUAD	chr2	3623451	3623451	C	G	Silent	p.L40L	1
RPS7	CESC	chr2	3627876	3627876	A	G	Missense_Mutation		1

Copy number variation (CNV) of RPS7
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS7
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
35694	Non-Cancer	ERR315486	HBD	chr11	5255599	-	RPS7	chr2	3624082	+
78120	N/A	BM014024	RPS7	chr2	3628509	+	NSF	chr17	44799467	-
88738	N/A	AV697533	RPS7	chr2	3623132	-	PEX19	chr1	160254909	-
98359	N/A	U16258	RPS7	chr2	3623189	-	TONSL	chr8	145668562	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPS7	0.00356283982688197	0.1
MESO	RPS7	0.0349385982073571	0.94
BRCA	RPS7	0.0449837550741867	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPS7	0.00232418867739772	0.074
BRCA	RPS7	2.75348820087739e-05	0.00091

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1260899	Anemia, Diamond-Blackfan	3	GENOMICS_ENGLAND
C2675511	Diamond-Blackfan Anemia 8	2	CTD_human;GENOMICS_ENGLAND
C0006142	Malignant neoplasm of breast	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C4704874	Mammary Carcinoma, Human	1	CTD_human