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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS8 (NCBI Gene ID:6202)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS8
	Gene ID: 6202
	Gene Symbol	RPS8
	Gene ID	6202
	Gene Name	ribosomal protein S8
	Synonyms	S8
	Cytomap	1p34.1
	Type of Gene	protein-coding
	Description	40S ribosomal protein S8OK/SW-cl.83small ribosomal subunit protein eS8
	Modification date	20200313
	UniProtAcc	P62241

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS8	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS8[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS8	CDK11p46 and RPS8 associate with each other and suppress translation in a synergistic manner	21371428

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000396651	45241705	45241812	Frame-shift
ENST00000396651	45242346	45242446	Frame-shift
ENST00000396651	45243285	45243461	Frame-shift
ENST00000396651	45243671	45243801	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	RPS8	-2.73463137299833	0.00134906742748461
PRAD	RPS8	1.32957024497066	0.00418162555035067
LUSC	RPS8	-1.95298795124964	0.00724217523600344
KIRC	RPS8	-3.97243608476641	1.19932271980764e-10
KIRP	RPS8	-1.20432400687215	7.40401446819306e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
CESC	RPS8	0.063083938	0.000199393
STAD	RPS8	-0.045054363	0.029809789
LAML	RPS8	0.017115654	0.032066907

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS8 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	RPS8	PFDN5	0.809494587	1.68E-11
CHOL	CGC	RPS8	NACA	0.823747368	3.67E-12
CHOL	Epifactor	RPS8	FBL	0.841067133	4.78E-13
CHOL	TSG	RPS8	GNB2L1	0.818348204	6.63E-12
DLBC	Cell metabolism gene	RPS8	SNRPD2	0.82923264	3.33E-13
DLBC	Cell metabolism gene	RPS8	FAU	0.833397372	1.98E-13
DLBC	CGC	RPS8	NACA	0.836099513	1.40E-13
DLBC	Epifactor	RPS8	FBL	0.805628534	4.99E-12
DLBC	TSG	RPS8	GAS5	0.80630026	4.65E-12
DLBC	TSG	RPS8	GNB2L1	0.891099118	2.15E-17
GBM	Cell metabolism gene	RPS8	TIMM9	0.805650644	1.67E-40
GBM	Cell metabolism gene	RPS8	CCT4	0.812733352	9.83E-42
GBM	Cell metabolism gene	RPS8	PIGC	0.814017076	5.81E-42
GBM	Cell metabolism gene	RPS8	PSMB4	0.815259959	3.48E-42
GBM	Cell metabolism gene	RPS8	PFDN5	0.822530096	1.59E-43
GBM	Cell metabolism gene	RPS8	SNRPG	0.823111752	1.24E-43
GBM	Cell metabolism gene	RPS8	PSMA5	0.841844956	2.13E-47
GBM	Cell metabolism gene	RPS8	SSR4	0.843003186	1.20E-47
GBM	Cell metabolism gene	RPS8	FAU	0.845177783	4.05E-48
GBM	Cell metabolism gene	RPS8	SSR2	0.866542954	3.47E-53
GBM	TF	RPS8	GTF2B	0.815560744	3.07E-42
GBM	TSG	RPS8	GAS5	0.867287929	2.23E-53
KICH	TSG	RPS8	GAS5	0.816859825	5.56E-23
KIRP	Cell metabolism gene	RPS8	SNRPD2	0.823108528	7.07E-81
KIRP	TSG	RPS8	GAS5	0.833044225	1.56E-84
LGG	Epifactor	RPS8	FBL	0.844655967	2.07E-145
LIHC	TSG	RPS8	GNB2L1	0.806488358	3.96E-98
PCPG	TSG	RPS8	GNB2L1	0.823984028	1.62E-47
PRAD	Cell metabolism gene	RPS8	NME2	0.804828912	2.91E-126
PRAD	Cell metabolism gene	RPS8	SNRPD2	0.812573916	1.41E-130
PRAD	Cell metabolism gene	RPS8	TIMM9	0.832549598	1.08E-142
PRAD	Cell metabolism gene	RPS8	FAU	0.839415077	3.11E-147
PRAD	CGC	RPS8	NACA	0.882370818	1.50E-181
PRAD	Epifactor	RPS8	FBL	0.837850649	3.52E-146
PRAD	TF	RPS8	ZNF581	0.800393488	7.03E-124
PRAD	TF	RPS8	NME2	0.804828912	2.91E-126
PRAD	TSG	RPS8	GAS5	0.861651583	1.50E-163
PRAD	TSG	RPS8	GNB2L1	0.916557528	2.76E-220
THCA	Cell metabolism gene	RPS8	FAU	0.812188026	1.63E-135
THCA	TSG	RPS8	GAS5	0.85165083	4.61E-162
THCA	TSG	RPS8	GNB2L1	0.87806557	1.36E-184
THYM	Cell metabolism gene	RPS8	SRM	0.800610195	1.83E-28
THYM	Cell metabolism gene	RPS8	IDH3G	0.801045533	1.63E-28
THYM	Cell metabolism gene	RPS8	SNRPD1	0.802804097	1.01E-28
THYM	Cell metabolism gene	RPS8	SMPD2	0.803754099	7.82E-29
THYM	Cell metabolism gene	RPS8	POLD2	0.803922045	7.47E-29
THYM	Cell metabolism gene	RPS8	GCAT	0.805290631	5.12E-29
THYM	Cell metabolism gene	RPS8	APOA1	0.805359281	5.03E-29
THYM	Cell metabolism gene	RPS8	EXOSC5	0.809595339	1.54E-29
THYM	Cell metabolism gene	RPS8	SNRPB	0.810235244	1.28E-29
THYM	Cell metabolism gene	RPS8	TOMM22	0.811532153	8.86E-30
THYM	Cell metabolism gene	RPS8	PSMB3	0.812424624	6.85E-30
THYM	Cell metabolism gene	RPS8	POLR2F	0.812741147	6.26E-30
THYM	Cell metabolism gene	RPS8	EXOSC1	0.812846185	6.07E-30
THYM	Cell metabolism gene	RPS8	UROD	0.815897089	2.50E-30
THYM	Cell metabolism gene	RPS8	APRT	0.819136592	9.54E-31
THYM	Cell metabolism gene	RPS8	ACOT8	0.821080694	5.30E-31
THYM	Cell metabolism gene	RPS8	LSM5	0.822139347	3.84E-31
THYM	Cell metabolism gene	RPS8	ITPA	0.825717962	1.27E-31
THYM	Cell metabolism gene	RPS8	PGLS	0.829741054	3.56E-32
THYM	Cell metabolism gene	RPS8	SSR2	0.835205104	5.97E-33
THYM	Cell metabolism gene	RPS8	FPGS	0.835933055	4.68E-33
THYM	Cell metabolism gene	RPS8	PFDN5	0.837642096	2.64E-33
THYM	Cell metabolism gene	RPS8	PSMB7	0.838997055	1.66E-33
THYM	Cell metabolism gene	RPS8	TIMM13	0.841561399	6.88E-34
THYM	Cell metabolism gene	RPS8	SNRPD3	0.84178718	6.36E-34
THYM	Cell metabolism gene	RPS8	PSMD13	0.849378447	4.22E-35
THYM	Cell metabolism gene	RPS8	SLC27A5	0.854310712	6.69E-36
THYM	Cell metabolism gene	RPS8	PSMC3	0.8544857	6.25E-36
THYM	Cell metabolism gene	RPS8	LSM2	0.862689382	2.48E-37
THYM	Cell metabolism gene	RPS8	TIMM8B	0.873283826	2.79E-39
THYM	Cell metabolism gene	RPS8	SNRPD2	0.881303061	7.07E-41
THYM	Cell metabolism gene	RPS8	FAU	0.920077631	1.14E-50
THYM	CGC	RPS8	RBM10	0.808560574	2.06E-29
THYM	CGC	RPS8	TFPT	0.831686301	1.90E-32
THYM	CGC	RPS8	SDHAF2	0.850044736	3.31E-35
THYM	Epifactor	RPS8	RBX1	0.803250233	8.97E-29
THYM	Epifactor	RPS8	MBD3	0.804506444	6.36E-29
THYM	Epifactor	RPS8	EXOSC5	0.809595339	1.54E-29
THYM	Epifactor	RPS8	EXOSC1	0.812846185	6.07E-30
THYM	Epifactor	RPS8	CCDC101	0.814966872	3.28E-30
THYM	Epifactor	RPS8	INO80E	0.816489437	2.10E-30
THYM	Epifactor	RPS8	PRPF31	0.816682721	1.98E-30
THYM	Epifactor	RPS8	CXXC1	0.817828358	1.41E-30
THYM	Epifactor	RPS8	PPP4C	0.819848457	7.70E-31
THYM	Epifactor	RPS8	SIRT6	0.821118604	5.24E-31
THYM	Epifactor	RPS8	ZNHIT1	0.821732881	4.35E-31
THYM	Epifactor	RPS8	C17orf49	0.824630708	1.78E-31
THYM	Epifactor	RPS8	TFPT	0.831686301	1.90E-32
THYM	Epifactor	RPS8	NOC2L	0.833849312	9.35E-33
THYM	Epifactor	RPS8	RUVBL2	0.837790422	2.51E-33
THYM	Epifactor	RPS8	DMAP1	0.838866377	1.74E-33
THYM	Epifactor	RPS8	SS18L2	0.850487566	2.81E-35
THYM	Epifactor	RPS8	BRMS1	0.856327686	3.08E-36
THYM	Epifactor	RPS8	FBL	0.872683628	3.63E-39
THYM	Epifactor	RPS8	TAF10	0.878920177	2.16E-40
THYM	IUPHAR	RPS8	SMPD2	0.803754099	7.82E-29
THYM	IUPHAR	RPS8	PPIA	0.81278187	6.18E-30
THYM	IUPHAR	RPS8	CSNK2B	0.821000875	5.43E-31
THYM	IUPHAR	RPS8	SIRT6	0.821118604	5.24E-31
THYM	IUPHAR	RPS8	SLC27A5	0.854310712	6.69E-36
THYM	TF	RPS8	ZNF787	0.800118939	2.09E-28
THYM	TF	RPS8	MBD3	0.804506444	6.36E-29
THYM	TF	RPS8	CXXC1	0.817828358	1.41E-30
THYM	TF	RPS8	THAP3	0.822527719	3.41E-31
THYM	TF	RPS8	ZNF444	0.833705337	9.80E-33
THYM	TF	RPS8	ZNF691	0.835901282	4.73E-33
THYM	TF	RPS8	ZNF428	0.848816482	5.19E-35
THYM	TF	RPS8	THYN1	0.872542278	3.87E-39
THYM	TSG	RPS8	PLEKHO1	0.800718986	1.78E-28
THYM	TSG	RPS8	HTRA2	0.81453549	3.72E-30
THYM	TSG	RPS8	SIRT6	0.821118604	5.24E-31
THYM	TSG	RPS8	NPRL2	0.824391733	1.92E-31
THYM	TSG	RPS8	TSSC4	0.825029867	1.58E-31
THYM	TSG	RPS8	PFN1	0.82900798	4.50E-32
THYM	TSG	RPS8	PARK7	0.836207725	4.27E-33
THYM	TSG	RPS8	BRMS1	0.856327686	3.08E-36
THYM	TSG	RPS8	AIP	0.860120442	6.97E-37
THYM	TSG	RPS8	GLTSCR2	0.902449442	1.04E-45
THYM	TSG	RPS8	GNB2L1	0.918763305	2.91E-50
UCEC	TSG	RPS8	GNB2L1	0.801406393	2.68E-46
UCS	Cell metabolism gene	RPS8	SRM	0.800610195	1.83E-28
UCS	Cell metabolism gene	RPS8	IDH3G	0.801045533	1.63E-28
UCS	Cell metabolism gene	RPS8	SNRPD1	0.802804097	1.01E-28
UCS	Cell metabolism gene	RPS8	SMPD2	0.803754099	7.82E-29
UCS	Cell metabolism gene	RPS8	POLD2	0.803922045	7.47E-29
UCS	Cell metabolism gene	RPS8	GCAT	0.805290631	5.12E-29
UCS	Cell metabolism gene	RPS8	APOA1	0.805359281	5.03E-29
UCS	Cell metabolism gene	RPS8	EXOSC5	0.809595339	1.54E-29
UCS	Cell metabolism gene	RPS8	SNRPB	0.810235244	1.28E-29
UCS	Cell metabolism gene	RPS8	TOMM22	0.811532153	8.86E-30
UCS	Cell metabolism gene	RPS8	PSMB3	0.812424624	6.85E-30
UCS	Cell metabolism gene	RPS8	POLR2F	0.812741147	6.26E-30
UCS	Cell metabolism gene	RPS8	EXOSC1	0.812846185	6.07E-30
UCS	Cell metabolism gene	RPS8	UROD	0.815897089	2.50E-30
UCS	Cell metabolism gene	RPS8	APRT	0.819136592	9.54E-31
UCS	Cell metabolism gene	RPS8	ACOT8	0.821080694	5.30E-31
UCS	Cell metabolism gene	RPS8	LSM5	0.822139347	3.84E-31
UCS	Cell metabolism gene	RPS8	ITPA	0.825717962	1.27E-31
UCS	Cell metabolism gene	RPS8	PGLS	0.829741054	3.56E-32
UCS	Cell metabolism gene	RPS8	SSR2	0.835205104	5.97E-33
UCS	Cell metabolism gene	RPS8	FPGS	0.835933055	4.68E-33
UCS	Cell metabolism gene	RPS8	PFDN5	0.837642096	2.64E-33
UCS	Cell metabolism gene	RPS8	PSMB7	0.838997055	1.66E-33
UCS	Cell metabolism gene	RPS8	TIMM13	0.841561399	6.88E-34
UCS	Cell metabolism gene	RPS8	SNRPD3	0.84178718	6.36E-34
UCS	Cell metabolism gene	RPS8	PSMD13	0.849378447	4.22E-35
UCS	Cell metabolism gene	RPS8	SLC27A5	0.854310712	6.69E-36
UCS	Cell metabolism gene	RPS8	PSMC3	0.8544857	6.25E-36
UCS	Cell metabolism gene	RPS8	LSM2	0.862689382	2.48E-37
UCS	Cell metabolism gene	RPS8	TIMM8B	0.873283826	2.79E-39
UCS	Cell metabolism gene	RPS8	SNRPD2	0.881303061	7.07E-41
UCS	Cell metabolism gene	RPS8	FAU	0.920077631	1.14E-50
UCS	CGC	RPS8	RBM10	0.808560574	2.06E-29
UCS	CGC	RPS8	TFPT	0.831686301	1.90E-32
UCS	CGC	RPS8	SDHAF2	0.850044736	3.31E-35
UCS	Epifactor	RPS8	RBX1	0.803250233	8.97E-29
UCS	Epifactor	RPS8	MBD3	0.804506444	6.36E-29
UCS	Epifactor	RPS8	EXOSC5	0.809595339	1.54E-29
UCS	Epifactor	RPS8	EXOSC1	0.812846185	6.07E-30
UCS	Epifactor	RPS8	CCDC101	0.814966872	3.28E-30
UCS	Epifactor	RPS8	INO80E	0.816489437	2.10E-30
UCS	Epifactor	RPS8	PRPF31	0.816682721	1.98E-30
UCS	Epifactor	RPS8	CXXC1	0.817828358	1.41E-30
UCS	Epifactor	RPS8	PPP4C	0.819848457	7.70E-31
UCS	Epifactor	RPS8	SIRT6	0.821118604	5.24E-31
UCS	Epifactor	RPS8	ZNHIT1	0.821732881	4.35E-31
UCS	Epifactor	RPS8	C17orf49	0.824630708	1.78E-31
UCS	Epifactor	RPS8	TFPT	0.831686301	1.90E-32
UCS	Epifactor	RPS8	NOC2L	0.833849312	9.35E-33
UCS	Epifactor	RPS8	RUVBL2	0.837790422	2.51E-33
UCS	Epifactor	RPS8	DMAP1	0.838866377	1.74E-33
UCS	Epifactor	RPS8	SS18L2	0.850487566	2.81E-35
UCS	Epifactor	RPS8	BRMS1	0.856327686	3.08E-36
UCS	Epifactor	RPS8	FBL	0.872683628	3.63E-39
UCS	Epifactor	RPS8	TAF10	0.878920177	2.16E-40
UCS	IUPHAR	RPS8	SMPD2	0.803754099	7.82E-29
UCS	IUPHAR	RPS8	PPIA	0.81278187	6.18E-30
UCS	IUPHAR	RPS8	CSNK2B	0.821000875	5.43E-31
UCS	IUPHAR	RPS8	SIRT6	0.821118604	5.24E-31
UCS	IUPHAR	RPS8	SLC27A5	0.854310712	6.69E-36
UCS	TF	RPS8	ZNF787	0.800118939	2.09E-28
UCS	TF	RPS8	MBD3	0.804506444	6.36E-29
UCS	TF	RPS8	CXXC1	0.817828358	1.41E-30
UCS	TF	RPS8	THAP3	0.822527719	3.41E-31
UCS	TF	RPS8	ZNF444	0.833705337	9.80E-33
UCS	TF	RPS8	ZNF691	0.835901282	4.73E-33
UCS	TF	RPS8	ZNF428	0.848816482	5.19E-35
UCS	TF	RPS8	THYN1	0.872542278	3.87E-39
UCS	TSG	RPS8	PLEKHO1	0.800718986	1.78E-28
UCS	TSG	RPS8	HTRA2	0.81453549	3.72E-30
UCS	TSG	RPS8	SIRT6	0.821118604	5.24E-31
UCS	TSG	RPS8	NPRL2	0.824391733	1.92E-31
UCS	TSG	RPS8	TSSC4	0.825029867	1.58E-31
UCS	TSG	RPS8	PFN1	0.82900798	4.50E-32
UCS	TSG	RPS8	PARK7	0.836207725	4.27E-33
UCS	TSG	RPS8	BRMS1	0.856327686	3.08E-36
UCS	TSG	RPS8	AIP	0.860120442	6.97E-37
UCS	TSG	RPS8	GLTSCR2	0.902449442	1.04E-45
UCS	TSG	RPS8	GNB2L1	0.918763305	2.91E-50
UVM	Cell metabolism gene	RPS8	SEC11A	0.816433135	2.74E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS8	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS8	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS8	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPS8	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS8	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS8	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS8	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS8	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS8	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS8	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS8	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPS8	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS8	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS8	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS8	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS8	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPS8	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS8	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPS8	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPS8	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS8	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS8	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS8	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS8	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPS8	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPS8	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS8	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS8	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS8

ESR1, TERF1, TERF2, POT1, UBC, HDAC5, NOP56, STAU1, CALM1, EBNA-LP, NDRG1, SENP3, ARRB1, ARRB2, FBXO25, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, PPP2R1A, MID1, LRRK2, RPS4X, RPL10A, RPL11, RPL12, RPL13, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL23, RPL24, RPL27A, RPL30, RPL31, RPL35, RPL37A, RPL3, RPL4, RPL5, RPL6, RPL7A, RPL7, RPL8, RPL9, RPLP2, RPS11, RPS13, RPS14, RPS15A, RPS16, RPS19, RPS20, RPS23, RPS24, RPS25, RPS26, RPS28, RPS2, RPS3A, RPS3, RPS5, RPS6, RPSA, RPL23A, RPS7, RPS12, RPLP1, RPL22, RPLP0, RPS17, RPL36, RPS9, RPS10, RPL27, RPL17, RPS21, RPS27A, RPL32, EEF1A1, RPS29, FBL, NOP58, HNRNPA1, ILF3, NHP2L1, HNRNPM, ILF2, MYBBP1A, HNRNPU, GNL3, TUFM, SLC25A5, RPL10L, RPLP0P6, RPS27L, UTP15, NOP2, NIFK, NENF, GPATCH1, HADHB, HSP90AA5P, VPRBP, MAGOH, EIF4A3, SMURF1, YWHAE, VCAM1, FN1, UBL4A, ITGA4, PAN2, CD81, IGSF8, ICAM1, PARP1, PARK2, ADRM1, LARP1, PSMC1, PSMC6, PSMD11, PSMD3, EIF3E, EIF3L, GNB2L1, PSMD1, PSMD13, PSMD8, RPS18, RPS27, WDR26, WIBG, TSR1, RPA3, RPA2, RPA1, ZBTB1, CEP250, TP53, TUBG1, TUBGCP3, TUBGCP4, VCP, HUWE1, FUS, CUL7, OBSL1, CCDC8, EED, RNF2, EBNA1BP2, MRPL28, NSA2, NPM1, MRPS27, LARP7, RPL26L1, RPL26, U2SURP, SF3B1, MRPL46, MRPS26, SF3B2, ZNF668, PTCD3, DKC1, IPO4, MRPL45, NAT10, ZSCAN25, AATF, HP1BP3, DDX27, MRPL9, MRPL32, MRPL40, MRPL3, MRPS34, DAP3, MRPL1, RBM19, SURF6, MRPL23, NOL10, MRPL22, MRPS5, MRPS7, MRPS22, MRPL10, MRPL24, MRPL49, LLPH, MRPS31, MRPL44, MRPS9, MRPS25, MRPL38, KRR1, ZC3H8, MRPL20, CHERP, NGDN, MRPS33, MRPL27, RBM34, MRPS11, MRPL47, MRPL16, MRPS24, GPATCH11, KIAA0020, MRPL19, MRPS14, ICT1, MRPL2, RPF2, MRPL21, MRPL13, MRPL43, MRPL17, PURA, RBMX2, HIST2H2AB, GADD45GIP1, RBM5, MRPL15, MRPL30, MRPS30, MRPL18, MRPL51, MRPL34, RPS6KB2, NTRK1, KPNA5, RPL13A, RPL35A, RPL38, LOC101929876, AHCYL2, ATP1B2, ATP1B3, BYSL, NCL, PABPC1, RPL10, RPL34, RPL3L, RPS15, UBA52, SFN, XPO1, IBTK, CBX8, NOP9, Eif3e, Rpl35, Srp72, Rrbp1, GAN, MCM2, Ksr1, RC3H1, CRBN, ZC3HAV1, CNBP, MRPS35, GPATCH4, MECP2, SART3, RBM4, E4F1, RRS1, ZBTB24, MRPL11, RPL28, MRPL57, RRP8, KNOP1, DGCR8, CYLD, INO80B, TRIM25, BRCA1, YAP1, MTF1, HSPA8, TMPO, ADSS, CTNNB1, PCBP1, TRIP4, API5, BMP4, GSK3A, PPIE, TGFB1, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, RNF4, CHD3, CHD4, TNF, RIOK1, HEXIM1, MEPCE, SNAI1, AGR2, RECQL4, REST, MYC, CDK9, Prkaa1, Prkab1, C1orf106, METTL14, KIAA1429, SIRPA, EIF4B, DCAF13, RC3H2, ZBTB7A, PHB, RBX1, NR2C2, PPP1CC, PPARG, ATXN3, VRK1, HIST1H4A, ZMYND19, SNRNP70, ITFG1, ARAF, HMGB1, PPP1CA, BIRC3, NFX1, WWP2, BRD7, Dnajc17, TRIM28, CMTR1, DLG3, DLG2, ARIH2, PINK1, TFCP2, WHSC1, FANCD2, HCVgp1, ZC3H18, GAB2, HMGN2, SSR3, SNIP1, M, nsp4, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, C1QBP, GRSF1, MKI67, LRRC59, INS, NMRAL1, NDN, Rnf183, BRD4, CIC, N, Apc2, RBM39, FBP1, MKRN1, LGALS9, IFI16, BKRF1, RIN3, DNAJC8, SPOP, TRIM37, AR, UFL1, DDRGK1, LCK, ATG7, ATG3, FZR1, WDR5, PAGE4, NUDCD2, NAA40, H2AFB3, SRSF5, UTP23, PURG, NPM3, YBX1, RSL1D1, ZNF48, PRKRA, FGF13, ADARB1, REXO4, ZBTB47, ZNF653, EPB41L4B, DDX31, PPAN-P2RY11, RSBN1, SIRT7, HIST1H1E, MRPL12, GLTSCR2, MAGEB2, CCDC137, ZFR, ZNF512, NOM1, MRPL37, MRPL41, ZFP91, MRPL55, CDK12, C7orf50, IMP3, RPSAP58, PHF6, SRPK2, NOP16, NOL12, RPS26P11, MPHOSPH10, LUC7L, KRI1, CDC5L, MRPL4, GTPBP4, RPL36AL, DDX56, NOC3L, ZNF771, C1orf35, PRRC2C, TFB1M, ZCRB1, RSL24D1, DDX50, UTP14A, PURB, FTSJ3, LTV1, RRP12, CCDC59, PAK1IP1, CARD9, CBX6, RRP1B, MRPS15, DHX57, DDX10, PRRC2A, MRPL35, ZNF574, SPATS2, ZNF768, RIOK2, MRPL52, ABT1, RPL7L1, RPS4Y1, RRP1, GNL2, ZNF346, STAU2, DDX55, DDX54, ZNF579, MRPL48, SDAD1, METTL17, MRPL50, SREK1, CTCF, RPS4Y2, MRPS18A, UTP3, DHX8, SPATS2L, EPB41L5, ESF1, DTX3, SPRTN, BTF3, FBXW7, NLRP7, RCHY1, CCNF, PDE4B, KLF4, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPS8	chr1	45243311	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS8	KIRP	chr1	45242407	45242407	C	G	Missense_Mutation	p.L58V	3
RPS8	HNSC	chr1	45243773	45243773	G	A	Silent	p.E163E	2
RPS8	SKCM	chr1	45243706	45243706	G	A	Missense_Mutation	p.R141Q	2
RPS8	STAD	chr1	45244276	45244276	T	C	Silent	p.C182C	2
RPS8	LIHC	chr1	45243699	45243699	A	-	Frame_Shift_Del	p.K140fs	2
RPS8	UCEC	chr1	45242367	45242367	C	T	Silent	p.H44	2
RPS8	BLCA	chr1	45242394	45242394	G	A	Silent	p.K53K	2
RPS8	LIHC	chr1	45244267	45244267	G	-	Frame_Shift_Del	p.P179fs	2
RPS8	UCEC	chr1	45243294	45243294	C	T	Missense_Mutation	p.R74C	2
RPS8	UCEC	chr1	45243675	45243675	C	T	Missense_Mutation	p.P131S	2
RPS8	LUSC	chr1	45242381	45242381	G	T	Missense_Mutation	p.R49L	1
RPS8	BLCA	chr1	45241229	45241229	G	T	Missense_Mutation		1
RPS8	ESCA	chr1	45242355	45242355	C	G	Silent	p.P40P	1
RPS8	OV	chr1	45243434	45243434	C	T	Silent	p.P120P	1
RPS8	BLCA	chr1	45242394	45242394	G	A	Silent		1
RPS8	PRAD	chr1	45243356	45243356	G	C	Missense_Mutation	p.K94N	1
RPS8	BLCA	chr1	45244268	45244268	G	C	Missense_Mutation		1
RPS8	BLCA	chr1	45241246	45241246	C	G	Missense_Mutation		1
RPS8	KIRP	chr1	45242407	45242407	C	G	Missense_Mutation		1
RPS8	BLCA	chr1	45241235	45241235	C	G	Missense_Mutation		1
RPS8	KIRP	chr1	45242401	45242401	C	A	Missense_Mutation		1
RPS8	STAD	chr1	45243749	45243749	T	C	Silent	p.N155N	1
RPS8	BLCA	chr1	45243706	45243706	G	T	Missense_Mutation	p.R141L	1
RPS8	BLCA	chr1	45244268	45244268	G	C	Missense_Mutation	p.G180R	1
RPS8	LIHC	chr1	45243711	45243711	A	-	Frame_Shift_Del	p.K144fs	1
RPS8	ESCA	chr1	45243860	45243860	T	-	RNA	NULL	1
RPS8	LUSC	chr1	45243440	45243440	C	T	Silent	p.G122G	1
RPS8	ESCA	chr1	45242355	45242355	C	G	Silent	p.P40	1
RPS8	LUSC	chr1	45243441	45243441	C	T	Missense_Mutation	p.R123C	1
RPS8	BLCA	chr1	45243706	45243706	G	T	Missense_Mutation		1
RPS8	ESCA	chr1	45241271	45241271	G	T	Missense_Mutation	p.M1I	1

Copy number variation (CNV) of RPS8
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS8
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
90634	N/A	BD264992	ATP5G3	chr2	176043959	+	RPS8	chr1	45244343	-
90634	N/A	BG232142	CAV1	chr7	116186749	-	RPS8	chr1	45244412	-
90634	N/A	AA595207	CTD-2066L21.3	chr5	33162973	-	RPS8	chr1	45244412	-
90634	N/A	AA641551	CTD-2066L21.3	chr5	33162971	-	RPS8	chr1	45244410	-
90634	N/A	BQ082553	DDA1	chr19	17431920	+	RPS8	chr1	45242583	+
90634	N/A	AA484091	GBE1	chr3	81562599	-	RPS8	chr1	45244412	-
90634	N/A	AA507756	GBE1	chr3	81562599	-	RPS8	chr1	45244410	-
90634	KIRC	TCGA-BP-4343-01A	GNPTAB	chr12	102179790	-	RPS8	chr1	45243286	+
90634	N/A	AK129640	GOLGA2	chr9	131023519	-	RPS8	chr1	45243738	+
90634	N/A	AA169514	KIF13A	chr6	17833721	-	RPS8	chr1	45244375	-
90634	N/A	BF920614	LRRC4C	chr11	41081143	+	RPS8	chr1	45243748	-
90634	STAD	TCGA-BR-A4J5-01A	PROSC	chr8	37623873	+	RPS8	chr1	45241706	+
90634	N/A	AA888704	RALGAPA1	chr14	36272050	-	RPS8	chr1	45243741	+
101647	N/A	DA657610	RPS8	chr1	45244127	+	AKT2	chr19	40761110	-
92118	N/A	EC562120	RPS8	chr1	45244263	+	BEST4	chr1	45249780	+
78161	BRCA	TCGA-E2-A1AZ-01A	RPS8	chr1	45243801	+	C1orf228	chr1	45189794	+
86820	N/A	BG577109	RPS8	chr1	45243717	+	CAGE1	chr6	7375646	+
89009	STAD	TCGA-IN-7808-01A	RPS8	chr1	45241604	+	CCL2	chr17	32582309	+
78161	N/A	AA484884	RPS8	chr1	45244409	+	CTD-2066L21.3	chr5	33162969	+
78161	N/A	AA550928	RPS8	chr1	45244412	+	CTD-2066L21.3	chr5	33162973	+
78161	N/A	BF526768	RPS8	chr1	45244410	+	CTD-2066L21.3	chr5	33162971	+
99835	COAD	TCGA-AA-A00Z-01A	RPS8	chr1	45241743	+	ETV5	chr3	185826703	-
84739	STAD	TCGA-IN-7808-01A	RPS8	chr1	45242446	+	GALT	chr9	34650366	+
78161	N/A	AA644022	RPS8	chr1	45244412	+	GBE1	chr3	81562599	+
78161	N/A	AB062401	RPS8	chr1	45244410	+	GBE1	chr3	81562599	+
78161	N/A	BG029738	RPS8	chr1	45244397	+	GBE1	chr3	81562599	+
78161	N/A	BG033159	RPS8	chr1	45244394	+	GBE1	chr3	81562599	+
78161	N/A	BI861814	RPS8	chr1	45244412	+	GGT2	chr22	21568725	-
78161	N/A	BU175454	RPS8	chr1	45243793	+	IFFO2	chr1	19267775	-
101286	N/A	BM016201	RPS8	chr1	45243717	+	KIAA1671	chr22	25401310	+
78161	SKCM	TCGA-D3-A5GT-01A	RPS8	chr1	45244349	+	KIF2C	chr1	45232498	+
96538	N/A	BM682967	RPS8	chr1	45243774	-	MAP3K7	chr6	91246054	+
103124	LAML	TCGA-AB-2874-03A	RPS8	chr1	45241581	+	MPO	chr17	56358272	-
103124	LAML	TCGA-AB-2993-03A	RPS8	chr1	45241578	+	MPO	chr17	56358276	-
91944	N/A	BF216948	RPS8	chr1	45244414	+	MYSM1	chr1	59150991	+
92611	N/A	AA483052	RPS8	chr1	45244382	+	NRXN3	chr14	79680117	-
92611	N/A	BG030091	RPS8	chr1	45244347	+	NRXN3	chr14	79680117	-
92611	N/A	BG033629	RPS8	chr1	45244353	+	NRXN3	chr14	79680117	-
92611	N/A	CB048564	RPS8	chr1	45244412	+	NRXN3	chr14	79680117	-
96539	STAD	TCGA-HU-A4H5	RPS8	chr1	45242446	+	OTUD7B	chr1	149936274	-
95196	N/A	BE835631	RPS8	chr1	45244019	-	RCBTB1	chr13	50140891	+
90634	N/A	BG230813	RPS8	chr1	45244373	+	RPS8	chr1	45244354	-
90634	N/A	EC529209	RPS8	chr1	45243370	-	RPS8	chr1	45244293	+
102021	OV	TCGA-24-1616	RPS8	chr1	45242446	+	TLN1	chr9	35698169	-
97511	N/A	BG565964	RPS8	chr1	45241605	+	USP47	chr11	11970041	+
101680	N/A	BU588018	RPS8	chr1	45244412	+	ZNF627	chr19	11683891	+
90634	N/A	EC559444	THEGL	chr4	57409209	-	RPS8	chr1	45243736	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPS8	0.00159610313827365	0.045
SARC	RPS8	0.0466591477551668	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPS8	0.0118871721510692	0.37
LGG	RPS8	0.000632807005220265	0.02
BRCA	RPS8	4.44033223437933e-05	0.0015
THYM	RPS8	0.0408437824396013	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0006142	Malignant neoplasm of breast	1	CTD_human
C0030567	Parkinson Disease	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C4704874	Mammary Carcinoma, Human	1	CTD_human