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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS12 (NCBI Gene ID:6206)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS12
	Gene ID: 6206
	Gene Symbol	RPS12
	Gene ID	6206
	Gene Name	ribosomal protein S12
	Synonyms	S12
	Cytomap	6q23.2
	Type of Gene	protein-coding
	Description	40S ribosomal protein S12small ribosomal subunit protein eS12
	Modification date	20200313
	UniProtAcc	P25398

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS12	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS12[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS12	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000230050	133136110	133136227	In-frame
ENST00000230050	133137599	133137702	Frame-shift
ENST00000230050	133138098	133138200	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000230050	133136110	133136227	648	225	341	132	5	43
ENST00000230050	133138098	133138200	648	445	546	132	78	112

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P25398	5	43	2	132	Chain	ID=PRO_0000122323;Note=40S ribosomal protein S12
P25398	78	112	2	132	Chain	ID=PRO_0000122323;Note=40S ribosomal protein S12
P25398	78	112	99	99	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	RPS12	1.26997381758431	0.00308787822723389
BLCA	RPS12	-1.47804673440421	0.0204124450683594
BRCA	RPS12	-4.91239327478244	1.85340619742495e-09

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KIRC	RPS12	-0.022427575	0.017671739
ESCA	RPS12	-0.036291283	0.048439931

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS12 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	RPS12	UROD	0.803613431	6.18E-12
DLBC	Cell metabolism gene	RPS12	SNRPD2	0.805841704	4.88E-12
DLBC	Cell metabolism gene	RPS12	PFDN5	0.80974986	3.20E-12
DLBC	Cell metabolism gene	RPS12	PGLS	0.845812386	3.84E-14
DLBC	Cell metabolism gene	RPS12	ECHS1	0.847716974	2.95E-14
DLBC	CGC	RPS12	NTHL1	0.801734802	7.53E-12
DLBC	CGC	RPS12	ASPSCR1	0.831629966	2.48E-13
DLBC	Epifactor	RPS12	MBD3	0.804471434	5.65E-12
DLBC	Epifactor	RPS12	DMAP1	0.808780318	3.55E-12
DLBC	Epifactor	RPS12	ZNHIT1	0.829996068	3.03E-13
DLBC	TF	RPS12	MBD3	0.804471434	5.65E-12
DLBC	TF	RPS12	ZNF775	0.806776884	4.41E-12
DLBC	TF	RPS12	ZNF428	0.808393452	3.71E-12
DLBC	TSG	RPS12	GADD45GIP1	0.807785543	3.96E-12
DLBC	TSG	RPS12	GLTSCR2	0.848766287	2.55E-14
DLBC	TSG	RPS12	GNB2L1	0.850507678	1.99E-14
LGG	Cell metabolism gene	RPS12	FAU	0.801180758	7.88E-120
LGG	CGC	RPS12	NACA	0.808181066	1.69E-123
THYM	Cell metabolism gene	RPS12	PSMC3	0.806597367	3.57E-29
THYM	Cell metabolism gene	RPS12	SLC27A5	0.806724528	3.44E-29
THYM	Cell metabolism gene	RPS12	FPGS	0.810235828	1.28E-29
THYM	Cell metabolism gene	RPS12	FAU	0.815126063	3.13E-30
THYM	Cell metabolism gene	RPS12	PSMD13	0.816589592	2.03E-30
THYM	Cell metabolism gene	RPS12	SNRPD2	0.816666888	1.99E-30
THYM	Cell metabolism gene	RPS12	SSR2	0.825353178	1.42E-31
THYM	Cell metabolism gene	RPS12	LSM2	0.86085533	5.20E-37
THYM	Epifactor	RPS12	CXXC1	0.811640938	8.59E-30
THYM	Epifactor	RPS12	FBL	0.853064341	1.07E-35
THYM	IUPHAR	RPS12	MFSD2B	0.804568902	6.25E-29
THYM	IUPHAR	RPS12	SLC27A5	0.806724528	3.44E-29
THYM	IUPHAR	RPS12	CSNK2B	0.827507963	7.24E-32
THYM	TF	RPS12	THYN1	0.802040309	1.25E-28
THYM	TF	RPS12	CXXC1	0.811640938	8.59E-30
THYM	TSG	RPS12	AIP	0.800936166	1.68E-28
THYM	TSG	RPS12	GNB2L1	0.853599793	8.76E-36
THYM	TSG	RPS12	GLTSCR2	0.861419487	4.15E-37
UCS	Cell metabolism gene	RPS12	PSMC3	0.806597367	3.57E-29
UCS	Cell metabolism gene	RPS12	SLC27A5	0.806724528	3.44E-29
UCS	Cell metabolism gene	RPS12	FPGS	0.810235828	1.28E-29
UCS	Cell metabolism gene	RPS12	FAU	0.815126063	3.13E-30
UCS	Cell metabolism gene	RPS12	PSMD13	0.816589592	2.03E-30
UCS	Cell metabolism gene	RPS12	SNRPD2	0.816666888	1.99E-30
UCS	Cell metabolism gene	RPS12	SSR2	0.825353178	1.42E-31
UCS	Cell metabolism gene	RPS12	LSM2	0.86085533	5.20E-37
UCS	Epifactor	RPS12	CXXC1	0.811640938	8.59E-30
UCS	Epifactor	RPS12	FBL	0.853064341	1.07E-35
UCS	IUPHAR	RPS12	MFSD2B	0.804568902	6.25E-29
UCS	IUPHAR	RPS12	SLC27A5	0.806724528	3.44E-29
UCS	IUPHAR	RPS12	CSNK2B	0.827507963	7.24E-32
UCS	TF	RPS12	THYN1	0.802040309	1.25E-28
UCS	TF	RPS12	CXXC1	0.811640938	8.59E-30
UCS	TSG	RPS12	AIP	0.800936166	1.68E-28
UCS	TSG	RPS12	GNB2L1	0.853599793	8.76E-36
UCS	TSG	RPS12	GLTSCR2	0.861419487	4.15E-37
UVM	Cell metabolism gene	RPS12	LTA4H	0.825074826	4.97E-21
UVM	IUPHAR	RPS12	LTA4H	0.825074826	4.97E-21
UVM	TSG	RPS12	ST13	0.805676249	2.03E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS12	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS12	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS12	RPS16	-1.35957043617517	0.00019507110118866
STAD	RPS12	RPS23	1.85076760664576	0.000364991836249828
COAD	RPS12	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS12	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS12	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS12	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS12	RPL19	1.36901182894089	0.00250792503356934
LUAD	RPS12	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS12	RPS16	-6.16322798156577	0.0115764821363307
LUSC	RPS12	RPS23	1.46751169891047	0.0174932185880974
BLCA	RPS12	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS12	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS12	RPS11	1.35307548998204	0.0312207043170929
COAD	RPS12	RPS9	1.18612014402235	0.0381683111190796
LUSC	RPS12	RPL19	-2.14669889516666	0.044366810398747
UCEC	RPS12	RPS23	-2.03658159814007	0.046875
KIRC	RPS12	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS12	RPS9	1.9331477546349	2.31299392089389e-07
KIRC	RPS12	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS12	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS12	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS12	RPS9	-1.32680816440987	6.53264115309597e-07
KIRC	RPS12	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS12	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRP	RPS12	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS12	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS12	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS12

USP38, IKBKG, UBC, CD4, SIRT7, CUL3, CDK2, CUL1, RPS4X, APP, RPL11, RPL14, RPL18A, RPL6, RPL9, RPS11, RPS15A, RPS16, RPS23, RPS2, RPS6, RPS19, RPL18, RPL5, RPL7A, RPS26, RPL23, RPS8, RPL21, RPL10A, RPL15, RPL31, RPS13, RPS28, RPL24, RPL7, RPS5, RPS3, RPS3A, RPL12, RPL19, RPS24, RPL4, RPL37A, RPL38, RPS21, RPL29, RPS27A, RPL17, RPLP0P6, RPL10L, VAMP2, RPS27L, NDUFS6, PRDX5, ESR1, SMURF1, FN1, VCAM1, UBL4A, PAN2, NPM1, BAG3, EIF3A, EIF3E, RPSA, LARP1, PNO1, PSMC6, PSMD1, PSMD4, PSMD8, RANBP9, DYNC1LI1, EIF3CL, EIF3D, GNB2L1, HNRNPD, PSMD2, RPL35, RPS10, RPS18, RPS20, RPS25, RPS29, RPS7, RPS9, RPS14, RPS27, TSR1, WIBG, CEP250, RNF2, ABCE1, FAU, RPL10, RPL13, RPL13A, RPL22, RPL27, RPL27A, RPL30, RPL35A, RPL36, RPL23A, RPL3, RPLP0, LOC101929876, HIST1H3E, HNRNPU, NOP56, CBX8, Cbx1, Eif3a, Eif3e, Rpl35, Srp72, Rrbp1, MCM2, EIF2S2, ZNF746, CDC14B, PTP4A1, RRS1, PTPN7, NCL, CYLD, TRIM25, BRCA1, CFTR, FBXO7, ACO2, HSPA8, DIMT1, HDAC4, TGFB1, UBE2M, PRPF8, AAR2, PIH1D1, EFTUD2, TNIP2, CHD3, CHD4, RNF31, TNF, PRKCZ, ESR2, HEXIM1, MEPCE, LARP7, PPT1, RECQL4, DCPS, EIF4B, RC3H1, RC3H2, ATG16L1, ACTC1, NR2C2, PPP1CC, ATXN3, HIST1H4A, RNF213, SNRNP70, Dppa3, ITFG1, HMGB1, MARCKS, BIRC3, STAU1, NFX1, WWP2, SOX2, PLEKHA4, FANCD2, ZC3H18, GCH1, ZNF124, BCL7A, nsp1, NEK4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, INS, NINL, CIC, Apc2, FBP1, BKRF1, INSIG1, INSIG2, RIN3, DNAJC8, DNAJC15, DNAJC19, DDX58, PARK2, UFL1, DDRGK1, TRIM37, FZR1, WDR5, NAA40, SPRTN, BTF3, SLFN11, RCHY1, TAX1BP1, N, BRD3,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS12	BLCA	chr6	133138134	133138134	C	G	Silent		12
RPS12	BLCA	chr6	133138146	133138146	T	C	Silent		11
RPS12	CESC	chr6	133138134	133138134	C	G	Silent	p.G90G	9
RPS12	BLCA	chr6	133138137	133138137	T	C	Silent		6
RPS12	LGG	chr6	133138146	133138146	T	C	Silent	p.I94I	4
RPS12	UCEC	chr6	133136223	133136223	G	A	Missense_Mutation	p.D43N	2
RPS12	UCEC	chr6	133137686	133137686	A	G	Missense_Mutation	p.Q73R	2
RPS12	CHOL	chr6	133137642	133137642	G	T	Missense_Mutation		2
RPS12	STAD	chr6	133138636	133138636	T	C	Silent	p.S118S	2
RPS12	CHOL	chr6	133137642	133137642	G	T	Missense_Mutation	p.E58D	2
RPS12	GBM	chr6	133137703	133137703	G	T	Splice_Site		1
RPS12	BLCA	chr6	133138120	133138120	G	C	Missense_Mutation		1
RPS12	BLCA	chr6	133138189	133138189	G	T	Missense_Mutation		1
RPS12	LGG	chr6	133138166	133138166	G	A	Missense_Mutation	p.R101H	1
RPS12	BLCA	chr6	133136205	133136205	G	A	Missense_Mutation		1
RPS12	LGG	chr6	133138166	133138166	G	A	Missense_Mutation		1
RPS12	BLCA	chr6	133137650	133137650	A	G	Missense_Mutation	p.Y61C	1
RPS12	LIHC	chr6	133138678	133138678	A	G	Silent		1
RPS12	BLCA	chr6	133138120	133138120	G	C	Missense_Mutation	p.G86R	1
RPS12	LUSC	chr6	133136222	133136222	A	C	Missense_Mutation	p.L42F	1
RPS12	BLCA	chr6	133138189	133138189	G	T	Missense_Mutation	p.V109L	1
RPS12	PAAD	chr6	133138137	133138137	T	C	Silent	p.L91L	1
RPS12	PCPG	chr6	133138155	133138155	G	A	Silent	p.E97E	1
RPS12	BLCA	chr6	133137650	133137650	A	G	Missense_Mutation		1
RPS12	UCEC	chr6	133136205	133136205	G	A	Missense_Mutation	p.E37K	1
RPS12	GBM	chr6	133137703	133137703	G	T	Splice_Site	p.K78_splice	1

Copy number variation (CNV) of RPS12
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS12
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
95471	N/A	AA535396	ANKS1A	chr6	35038826	+	RPS12	chr6	133138706	-
95471	N/A	AX381540	ECHS1	chr10	135187164	+	RPS12	chr6	133135731	+
95471	STAD	TCGA-FP-8210-01A	FUS	chr16	31196463	+	RPS12	chr6	133136157	+
95471	STAD	TCGA-CD-8530-01A	LONRF1	chr8	12586410	-	RPS12	chr6	133138099	+
95471	COAD	TCGA-CM-4748-01A	MALAT1	chr11	65267132	+	RPS12	chr6	133138110	+
95471	N/A	BG272325	RABGAP1L	chr1	174559315	+	RPS12	chr6	133138703	-
102890	N/A	BG032206	RPS12	chr6	133138703	+	ANKS1A	chr6	35038826	-
99610	SARC	TCGA-DX-A1L0-01A	RPS12	chr6	133137702	+	COL3A1	chr2	189859267	+
103268	BRCA	TCGA-A2-A1G1	RPS12	chr6	133136227	+	HSH2D	chr19	16263361	+
100605	STAD	TCGA-BR-A4PE-01A	RPS12	chr6	133135752	+	LINC00152	chr2	87820726	+
92412	LUSC	TCGA-18-3421	RPS12	chr6	133135752	+	MRPL3	chr3	131190123	-
77357	N/A	AI394068	RPS12	chr6	133138642	-	NIPAL3	chr1	24745955	-
101354	N/A	CD050400	RPS12	chr6	133138698	+	PAK4	chr19	39669994	+
96928	N/A	GW493031	RPS12	chr6	133138702	+	PRMT3	chr11	20463356	-
97102	N/A	AV694293	RPS12	chr6	133138703	+	RABGAP1L	chr1	174559315	-
101915	Non-Cancer	ERR315333	RPS12	chr6	133136227	+	RBM39	chr20	34309799	-
100540	N/A	DA436799	RPS12	chr6	133138012	+	SERINC1	chr6	122792957	-
77357	STAD	TCGA-BR-A4J1	RPS12	chr6	133135921	+	SLC22A1	chr6	160579547	+
102729	N/A	BP319882	RPS12	chr6	133138703	+	SMYD3	chr1	246433184	-
95476	UCEC	TCGA-D1-A3DH-01A	TULP4	chr6	158735300	+	RPS12	chr6	133135871	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPS12	0.000814159309672779	0.023
SARC	RPS12	0.000950102327389131	0.026
LGG	RPS12	0.00543525637155273	0.14
COAD	RPS12	0.0247234034848622	0.62

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BRCA	RPS12	0.00845874359821077	0.27
PRAD	RPS12	0.0115421472960046	0.36
PAAD	RPS12	0.00444125502257175	0.15
OV	RPS12	0.0282594666766794	0.82
THYM	RPS12	0.0346431440017935	0.97
SARC	RPS12	0.0188263964584664	0.56

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source