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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS13 (NCBI Gene ID:6207)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS13
	Gene ID: 6207
	Gene Symbol	RPS13
	Gene ID	6207
	Gene Name	ribosomal protein S13
	Synonyms	S13
	Cytomap	11p15.1
	Type of Gene	protein-coding
	Description	40S ribosomal protein S13small ribosomal subunit protein uS15
	Modification date	20200327
	UniProtAcc	P62277

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS13	GO:0033119	negative regulation of RNA splicing	17881366

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS13	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS13[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS13	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000525634	17096643	17096744	Frame-shift
ENST00000525634	17097000	17097170	Frame-shift
ENST00000525634	17098714	17098793	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
COAD	RPS13	1.30175825100469	0.0357243716716767

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
HNSC	RPS13	-0.068320157	0.007663825
STAD	RPS13	-0.069047677	0.01790071
TGCT	RPS13	0.058580586	0.041386268
KICH	RPS13	0.035465549	0.042653556

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS13 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	RPS13	TIMM13	0.804834129	5.43E-12
DLBC	Cell metabolism gene	RPS13	PTDSS2	0.822405099	7.60E-13
DLBC	Cell metabolism gene	RPS13	PFDN5	0.827316169	4.22E-13
DLBC	Cell metabolism gene	RPS13	POLR2F	0.828651892	3.58E-13
DLBC	Cell metabolism gene	RPS13	TOMM22	0.835472538	1.52E-13
DLBC	Cell metabolism gene	RPS13	SNRPD2	0.852289272	1.54E-14
DLBC	Cell metabolism gene	RPS13	TIMM9	0.859926305	4.96E-15
DLBC	Cell metabolism gene	RPS13	NME2	0.871340382	7.98E-16
DLBC	Cell metabolism gene	RPS13	FAU	0.892504182	1.62E-17
DLBC	CGC	RPS13	NACA	0.859453207	5.33E-15
DLBC	Epifactor	RPS13	FBL	0.860736447	4.38E-15
DLBC	TF	RPS13	NME2	0.871340382	7.98E-16
DLBC	TSG	RPS13	GNB2L1	0.876496714	3.30E-16
GBM	Cell metabolism gene	RPS13	SSR4	0.800252128	1.34E-39
GBM	Cell metabolism gene	RPS13	PIGC	0.802376077	5.94E-40
GBM	Cell metabolism gene	RPS13	TIMM8B	0.804362961	2.76E-40
GBM	Cell metabolism gene	RPS13	PSMB3	0.804443803	2.67E-40
GBM	Cell metabolism gene	RPS13	GEMIN6	0.808004234	6.59E-41
GBM	Cell metabolism gene	RPS13	PSMA5	0.80965082	3.42E-41
GBM	Cell metabolism gene	RPS13	PFDN5	0.82419598	7.72E-44
GBM	Cell metabolism gene	RPS13	SNRPG	0.861508999	6.45E-52
GBM	Cell metabolism gene	RPS13	FAU	0.865870181	5.16E-53
GBM	Epifactor	RPS13	DPY30	0.842548742	1.50E-47
GBM	TF	RPS13	GTF2B	0.816229382	2.32E-42
LGG	Cell metabolism gene	RPS13	IMPDH2	0.810053749	1.66E-124
LGG	Cell metabolism gene	RPS13	FAU	0.844122311	4.75E-145
LGG	CGC	RPS13	NACA	0.871217821	2.77E-165
LGG	IUPHAR	RPS13	IMPDH2	0.810053749	1.66E-124
LGG	TSG	RPS13	GAS5	0.822575565	1.53E-131
MESO	TSG	RPS13	GNB2L1	0.805447905	5.20E-21
PAAD	Cell metabolism gene	RPS13	FAU	0.817662142	2.84E-45
PRAD	Cell metabolism gene	RPS13	FAU	0.800246277	8.42E-124
PRAD	Cell metabolism gene	RPS13	SNRPD2	0.805374324	1.47E-126
PRAD	Cell metabolism gene	RPS13	TIMM9	0.859171049	1.36E-161
PRAD	CGC	RPS13	NACA	0.865388365	1.43E-166
PRAD	Epifactor	RPS13	FBL	0.835379481	1.54E-144
PRAD	TSG	RPS13	GAS5	0.824311041	1.65E-137
PRAD	TSG	RPS13	GNB2L1	0.858150729	8.46E-161
THYM	Cell metabolism gene	RPS13	ACOT8	0.800082612	2.11E-28
THYM	Cell metabolism gene	RPS13	PSMB3	0.800424276	1.93E-28
THYM	Cell metabolism gene	RPS13	LSM4	0.800457794	1.91E-28
THYM	Cell metabolism gene	RPS13	POLR3K	0.80067805	1.80E-28
THYM	Cell metabolism gene	RPS13	DTYMK	0.800686797	1.80E-28
THYM	Cell metabolism gene	RPS13	PFDN5	0.801426866	1.47E-28
THYM	Cell metabolism gene	RPS13	POLA2	0.802550997	1.09E-28
THYM	Cell metabolism gene	RPS13	DGUOK	0.80275067	1.03E-28
THYM	Cell metabolism gene	RPS13	MTMR14	0.804216499	6.89E-29
THYM	Cell metabolism gene	RPS13	SMPD2	0.805919461	4.31E-29
THYM	Cell metabolism gene	RPS13	APRT	0.807422207	2.83E-29
THYM	Cell metabolism gene	RPS13	SNRPB	0.807977768	2.43E-29
THYM	Cell metabolism gene	RPS13	TALDO1	0.809223873	1.71E-29
THYM	Cell metabolism gene	RPS13	LSM3	0.809471022	1.59E-29
THYM	Cell metabolism gene	RPS13	PSME1	0.811257679	9.58E-30
THYM	Cell metabolism gene	RPS13	TIMM13	0.812535958	6.64E-30
THYM	Cell metabolism gene	RPS13	EXOSC1	0.819715708	8.01E-31
THYM	Cell metabolism gene	RPS13	PSMA5	0.823587472	2.46E-31
THYM	Cell metabolism gene	RPS13	SNRPD3	0.824985808	1.60E-31
THYM	Cell metabolism gene	RPS13	FPGS	0.826859089	8.89E-32
THYM	Cell metabolism gene	RPS13	PSMB7	0.828714332	4.94E-32
THYM	Cell metabolism gene	RPS13	ZNRD1	0.828791952	4.82E-32
THYM	Cell metabolism gene	RPS13	SLC27A5	0.835064019	6.25E-33
THYM	Cell metabolism gene	RPS13	LSM5	0.839933791	1.21E-33
THYM	Cell metabolism gene	RPS13	SSR2	0.840045542	1.16E-33
THYM	Cell metabolism gene	RPS13	SNRPD1	0.840316958	1.06E-33
THYM	Cell metabolism gene	RPS13	TIMM8B	0.863069742	2.13E-37
THYM	Cell metabolism gene	RPS13	PSMC3	0.866126704	6.04E-38
THYM	Cell metabolism gene	RPS13	SNRPD2	0.868346609	2.37E-38
THYM	Cell metabolism gene	RPS13	LSM2	0.869366755	1.53E-38
THYM	Cell metabolism gene	RPS13	PSMD13	0.881388906	6.78E-41
THYM	Cell metabolism gene	RPS13	FAU	0.889577853	1.19E-42
THYM	CGC	RPS13	TFPT	0.812460322	6.78E-30
THYM	CGC	RPS13	SDHAF2	0.855783604	3.80E-36
THYM	Epifactor	RPS13	TRIM28	0.802086423	1.23E-28
THYM	Epifactor	RPS13	DMAP1	0.802140321	1.21E-28
THYM	Epifactor	RPS13	MCRS1	0.803467036	8.46E-29
THYM	Epifactor	RPS13	PPM1G	0.806840122	3.33E-29
THYM	Epifactor	RPS13	C17orf49	0.812222595	7.27E-30
THYM	Epifactor	RPS13	TFPT	0.812460322	6.78E-30
THYM	Epifactor	RPS13	NOC2L	0.817239047	1.68E-30
THYM	Epifactor	RPS13	EXOSC1	0.819715708	8.01E-31
THYM	Epifactor	RPS13	RUVBL2	0.821412308	4.79E-31
THYM	Epifactor	RPS13	CXXC1	0.82507939	1.55E-31
THYM	Epifactor	RPS13	PPP4C	0.83333698	1.11E-32
THYM	Epifactor	RPS13	BRMS1	0.843689181	3.27E-34
THYM	Epifactor	RPS13	SS18L2	0.852669508	1.24E-35
THYM	Epifactor	RPS13	FBL	0.855833439	3.73E-36
THYM	Epifactor	RPS13	TAF10	0.873316838	2.75E-39
THYM	IUPHAR	RPS13	TRIM28	0.802086423	1.23E-28
THYM	IUPHAR	RPS13	SMPD2	0.805919461	4.31E-29
THYM	IUPHAR	RPS13	TWF2	0.811903437	7.96E-30
THYM	IUPHAR	RPS13	MFSD2B	0.829324869	4.06E-32
THYM	IUPHAR	RPS13	SLC27A5	0.835064019	6.25E-33
THYM	IUPHAR	RPS13	CSNK2B	0.838129386	2.24E-33
THYM	Kinase	RPS13	TRIM28	0.802086423	1.23E-28
THYM	TF	RPS13	GTF3A	0.801957287	1.28E-28
THYM	TF	RPS13	ZNF691	0.820382759	6.55E-31
THYM	TF	RPS13	ZNF428	0.824299525	1.98E-31
THYM	TF	RPS13	CXXC1	0.82507939	1.55E-31
THYM	TF	RPS13	ZNF444	0.840198068	1.10E-33
THYM	TF	RPS13	THYN1	0.877002028	5.24E-40
THYM	TSG	RPS13	HTRA2	0.804042325	7.22E-29
THYM	TSG	RPS13	PARK7	0.812633193	6.45E-30
THYM	TSG	RPS13	TSSC4	0.81381901	4.58E-30
THYM	TSG	RPS13	PFN1	0.8398094	1.26E-33
THYM	TSG	RPS13	BRMS1	0.843689181	3.27E-34
THYM	TSG	RPS13	AIP	0.867468338	3.44E-38
THYM	TSG	RPS13	GLTSCR2	0.88182632	5.51E-41
THYM	TSG	RPS13	GNB2L1	0.892274039	2.94E-43
UCS	Cell metabolism gene	RPS13	ACOT8	0.800082612	2.11E-28
UCS	Cell metabolism gene	RPS13	PSMB3	0.800424276	1.93E-28
UCS	Cell metabolism gene	RPS13	LSM4	0.800457794	1.91E-28
UCS	Cell metabolism gene	RPS13	POLR3K	0.80067805	1.80E-28
UCS	Cell metabolism gene	RPS13	DTYMK	0.800686797	1.80E-28
UCS	Cell metabolism gene	RPS13	PFDN5	0.801426866	1.47E-28
UCS	Cell metabolism gene	RPS13	POLA2	0.802550997	1.09E-28
UCS	Cell metabolism gene	RPS13	DGUOK	0.80275067	1.03E-28
UCS	Cell metabolism gene	RPS13	MTMR14	0.804216499	6.89E-29
UCS	Cell metabolism gene	RPS13	SMPD2	0.805919461	4.31E-29
UCS	Cell metabolism gene	RPS13	APRT	0.807422207	2.83E-29
UCS	Cell metabolism gene	RPS13	SNRPB	0.807977768	2.43E-29
UCS	Cell metabolism gene	RPS13	TALDO1	0.809223873	1.71E-29
UCS	Cell metabolism gene	RPS13	LSM3	0.809471022	1.59E-29
UCS	Cell metabolism gene	RPS13	PSME1	0.811257679	9.58E-30
UCS	Cell metabolism gene	RPS13	TIMM13	0.812535958	6.64E-30
UCS	Cell metabolism gene	RPS13	EXOSC1	0.819715708	8.01E-31
UCS	Cell metabolism gene	RPS13	PSMA5	0.823587472	2.46E-31
UCS	Cell metabolism gene	RPS13	SNRPD3	0.824985808	1.60E-31
UCS	Cell metabolism gene	RPS13	FPGS	0.826859089	8.89E-32
UCS	Cell metabolism gene	RPS13	PSMB7	0.828714332	4.94E-32
UCS	Cell metabolism gene	RPS13	ZNRD1	0.828791952	4.82E-32
UCS	Cell metabolism gene	RPS13	SLC27A5	0.835064019	6.25E-33
UCS	Cell metabolism gene	RPS13	LSM5	0.839933791	1.21E-33
UCS	Cell metabolism gene	RPS13	SSR2	0.840045542	1.16E-33
UCS	Cell metabolism gene	RPS13	SNRPD1	0.840316958	1.06E-33
UCS	Cell metabolism gene	RPS13	TIMM8B	0.863069742	2.13E-37
UCS	Cell metabolism gene	RPS13	PSMC3	0.866126704	6.04E-38
UCS	Cell metabolism gene	RPS13	SNRPD2	0.868346609	2.37E-38
UCS	Cell metabolism gene	RPS13	LSM2	0.869366755	1.53E-38
UCS	Cell metabolism gene	RPS13	PSMD13	0.881388906	6.78E-41
UCS	Cell metabolism gene	RPS13	FAU	0.889577853	1.19E-42
UCS	CGC	RPS13	TFPT	0.812460322	6.78E-30
UCS	CGC	RPS13	SDHAF2	0.855783604	3.80E-36
UCS	Epifactor	RPS13	TRIM28	0.802086423	1.23E-28
UCS	Epifactor	RPS13	DMAP1	0.802140321	1.21E-28
UCS	Epifactor	RPS13	MCRS1	0.803467036	8.46E-29
UCS	Epifactor	RPS13	PPM1G	0.806840122	3.33E-29
UCS	Epifactor	RPS13	C17orf49	0.812222595	7.27E-30
UCS	Epifactor	RPS13	TFPT	0.812460322	6.78E-30
UCS	Epifactor	RPS13	NOC2L	0.817239047	1.68E-30
UCS	Epifactor	RPS13	EXOSC1	0.819715708	8.01E-31
UCS	Epifactor	RPS13	RUVBL2	0.821412308	4.79E-31
UCS	Epifactor	RPS13	CXXC1	0.82507939	1.55E-31
UCS	Epifactor	RPS13	PPP4C	0.83333698	1.11E-32
UCS	Epifactor	RPS13	BRMS1	0.843689181	3.27E-34
UCS	Epifactor	RPS13	SS18L2	0.852669508	1.24E-35
UCS	Epifactor	RPS13	FBL	0.855833439	3.73E-36
UCS	Epifactor	RPS13	TAF10	0.873316838	2.75E-39
UCS	IUPHAR	RPS13	TRIM28	0.802086423	1.23E-28
UCS	IUPHAR	RPS13	SMPD2	0.805919461	4.31E-29
UCS	IUPHAR	RPS13	TWF2	0.811903437	7.96E-30
UCS	IUPHAR	RPS13	MFSD2B	0.829324869	4.06E-32
UCS	IUPHAR	RPS13	SLC27A5	0.835064019	6.25E-33
UCS	IUPHAR	RPS13	CSNK2B	0.838129386	2.24E-33
UCS	Kinase	RPS13	TRIM28	0.802086423	1.23E-28
UCS	TF	RPS13	GTF3A	0.801957287	1.28E-28
UCS	TF	RPS13	ZNF691	0.820382759	6.55E-31
UCS	TF	RPS13	ZNF428	0.824299525	1.98E-31
UCS	TF	RPS13	CXXC1	0.82507939	1.55E-31
UCS	TF	RPS13	ZNF444	0.840198068	1.10E-33
UCS	TF	RPS13	THYN1	0.877002028	5.24E-40
UCS	TSG	RPS13	HTRA2	0.804042325	7.22E-29
UCS	TSG	RPS13	PARK7	0.812633193	6.45E-30
UCS	TSG	RPS13	TSSC4	0.81381901	4.58E-30
UCS	TSG	RPS13	PFN1	0.8398094	1.26E-33
UCS	TSG	RPS13	BRMS1	0.843689181	3.27E-34
UCS	TSG	RPS13	AIP	0.867468338	3.44E-38
UCS	TSG	RPS13	GLTSCR2	0.88182632	5.51E-41
UCS	TSG	RPS13	GNB2L1	0.892274039	2.94E-43
UVM	Cell metabolism gene	RPS13	SSR2	0.805727479	2.01E-19
UVM	Cell metabolism gene	RPS13	FAU	0.882599921	2.75E-27
UVM	CGC	RPS13	NACA	0.802491677	3.58E-19
UVM	Epifactor	RPS13	FBL	0.890263924	2.30E-28
UVM	TF	RPS13	ZNF581	0.836535272	4.46E-22
UVM	TSG	RPS13	GLTSCR2	0.874587254	3.09E-26
UVM	TSG	RPS13	GNB2L1	0.878824036	8.79E-27

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS13	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS13	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS13	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPS13	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS13	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS13	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS13	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS13	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS13	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS13	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS13	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPS13	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS13	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS13	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS13	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS13	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPS13	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS13	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPS13	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPS13	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS13	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS13	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS13	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS13	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPS13	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPS13	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS13	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS13	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS13

MAP3K1, NFKB2, PDCD4, SRRM2, DCC, RBM39, EBNA-LP, RAD21, ARRB2, TCF3, SPP1, CUL3, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, PRAME, RPS4X, RPL30, RPL4, RPL6, RPS11, RPL8, RPL10A, RPL11, RPL12, RPL14, RPL18, RPL19, RPL21, RPL24, RPL27, RPL31, RPL37A, RPL5, RPL7A, RPL7, RPL9, RPS10, RPS14, RPS15A, RPS16, RPS19, RPS23, RPS24, RPS26, RPS2, RPS3A, RPS5, RPS7, RPS8, RPLP1, RPL23, RPS6, RPS15, RPS3, RPL10, RPL18A, RPS12, RPLP2, RPLP0, RPL22, RPL15, RPL3, RPL23A, RPS25, RPSA, RPS28, RPL13, RPS9, RPS20, RPS17, RPL38, FBL, RPL17, RPS21, RPS27A, FAU, EEF1A1, NOP58, NOP56, ILF3, MYBBP1A, HNRNPU, ILF2, RSL1D1, MOV10, NHP2L1, HNRNPM, U2AF1, TUFM, RPS27L, ANXA2, RNPS1, RPLP0P6, RPL10L, NFIA, PRPF6, NACA2, HNRNPA3, HIST1H2AD, ESR1, SMURF1, VCP, FN1, VCAM1, ITGA4, CD81, IGSF8, ICAM1, DYNC1I2, LARP1, PNO1, PSMC1, PSMC5, PSMD3, PSMD7, RANBP9, EIF3L, GNB2L1, KCMF1, LARS, RPS18, RPS27, RPS29, TSR1, WIBG, ZBTB1, CEP250, HAUS2, TUBG1, TP53, HUWE1, BRCA1, CUL7, RNF2, UBC, LUZP4, SURF2, PRR11, BRIX1, DIMT1, EIF2A, EIF3I, IMP3, NUMA1, RPL13A, RPL26, RPL26L1, RPL27A, RPL34, RPL35, RPL35A, RPL36, RPL37, ACIN1, RPL32, LOC101929876, SFN, NTRK1, PTEN, XPO1, AHSA1, NPM1, Eif3e, Rpl35, Srp72, Rrbp1, GAN, MCM2, Ksr1, RC3H1, RRS1, RBM34, WDR46, CNBP, ZC3HAV1, DGCR8, H2AFY2, MAGEB10, PPAN, PRPF38A, NCL, CYLD, TRIM25, MTF1, CFTR, TRIM14, IQGAP1, PPP1CC, PPP2R2A, BMP4, WDR77, TGFB1, ACO2, CCNT1, JUP, TRIP4, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, CHD4, LARP7, TNF, RIOK1, HEXIM1, MEPCE, RNF123, PPT1, SNAI1, RECQL4, DCPS, REST, ZFP36L2, MYC, CDK9, Prkaa1, Prkab1, RPS6KB2, EZR, GRWD1, METTL14, EIF4B, RC3H2, PHB, DISC1, NR2C2, CTCF, KRAS, ATXN3, VRK1, HIST1H4A, SNRNP70, Dppa3, ITFG1, ARAF, HMGB1, BIRC3, STAU1, NFX1, WWP2, MATR3, SOX2, PARK2, CMTR1, ARIH2, PLEKHA4, YAP1, TFCP2, FANCD2, NGB, HCVgp1, ZC3H18, MAP3K14, NREP, P4HA2, ORF8, NEK4, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, MAD2L2, KIF23, PRC1, INS, NDN, Rnf183, BRD4, E5b, RBM45, CDC27, N, Apc2, FBP1, MKRN1, RIN3, DNAJC2, KRR1, METTL17, SPOP, AR, UFL1, DDRGK1, TRIM37, ATG10, FZR1, WDR5, PAGE4, DHX57, ASCC3, KIF2A, NOC2L, SRSF4, SRSF3, DHX36, H2AFB3, TRMT1L, SURF6, APOBEC3C, NOG, ZNF346, HIST2H2AB, XRN1, ZNF689, ZBTB47, SRBD1, RBM28, ZCCHC6, BBX, ZNF273, LTV1, SPTY2D1, NOP14, NOB1, RBM19, LLPH, HIST1H1D, KRI1, UTP23, CMSS1, ASCC2, PRKRA, RPL7L1, SRP68, BMS1, ZNF70, E4F1, RPL36AL, FGF13, BLM, ADARB1, FGF17, SRSF5, SRSF6, PRR3, PARN, RRP12, HIST1H1B, ZC3H10, RIOK2, FGFBP1, NOP9, HIST1H1A, ZNF668, HIST1H1E, RPSAP58, MAGEB2, LIN28A, DTX3, SPRTN, BTF3, SLFN11, FBXW7, CLIP4, PPIL3, RBFOX2, Pcbp1, RCHY1, CCNF, CPEB1, KLF15, RB1CC1, KLF16, KLF4, KLF8, SOX15, SOX5, SOX6, TAL1, TLX1, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS13	CESC	chr11	17098993	17098993	G	C	Missense_Mutation		4
RPS13	CESC	chr11	17098993	17098993	G	C	Missense_Mutation	p.R19G	4
RPS13	HNSC	chr11	17095985	17095985	C	G	Missense_Mutation	p.A151P	2
RPS13	UCEC	chr11	17097026	17097026	C	T	Missense_Mutation	p.R99Q	2
RPS13	KIRC	chr11	17098784	17098784	A	C	Missense_Mutation	p.L28V	2
RPS13	PAAD	chr11	17097027	17097027	G	T	Silent	p.R99R	2
RPS13	CESC	chr11	17097005	17097005	C	G	Missense_Mutation		2
RPS13	SKCM	chr11	17096727	17096727	G	A	Silent	p.F113F	2
RPS13	LIHC	chr11	17095976	17095976	A	-	Frame_Shift_Del	p.F142fs	2
RPS13	SKCM	chr11	17097072	17097072	G	A	Missense_Mutation	p.L84F	2
RPS13	STAD	chr11	17098745	17098745	C	T	Missense_Mutation	p.A41T	2
RPS13	ESCA	chr11	17098716	17098716	G	A	Silent		2
RPS13	LUAD	chr11	17097027	17097027	G	A	Nonsense_Mutation	p.R99*	2
RPS13	BLCA	chr11	17099182	17099182	G	A	Missense_Mutation	p.R3C	2
RPS13	PAAD	chr11	17097027	17097027	G	T	Silent		1
RPS13	BLCA	chr11	17098723	17098723	G	T	Nonsense_Mutation	p.S48*	1
RPS13	LIHC	chr11	17099258	17099258	G	C	Missense_Mutation		1
RPS13	SARC	chr11	17099248	17099248	C	G	RNA	NULL	1
RPS13	LIHC	chr11	17099257	17099257	G	T	Missense_Mutation		1
RPS13	SKCM	chr11	17097113	17097113	T	G	Missense_Mutation	p.K70T	1
RPS13	LIHC	chr11	17096659	17096659	G	A	Missense_Mutation		1
RPS13	SKCM	chr11	17098715	17098715	C	A	Missense_Mutation	p.G51C	1
RPS13	CESC	chr11	17097005	17097005	C	G	Missense_Mutation	p.R106T	1
RPS13	LIHC	chr11	17099170	17099170	G	A	Missense_Mutation	p.P7S	1
RPS13	COAD	chr11	17098743	17098743	G	T	Silent	p.A41A	1
RPS13	COAD	chr11	17099177	17099177	C	T	Missense_Mutation	p.M4I	1
RPS13	LIHC	chr11	17097040	17097040	T	-	Frame_Shift_Del	p.K94fs	1
RPS13	SKCM	chr11	17096726	17096726	G	A	Missense_Mutation	p.R114C	1
RPS13	ESCA	chr11	17098716	17098716	G	A	Silent	p.I50	1
RPS13	LIHC	chr11	17095979	17095979	T	-	Frame_Shift_Del	p.K141fs	1
RPS13	BLCA	chr11	17099182	17099182	G	A	Missense_Mutation		1
RPS13	STAD	chr11	17099016	17099016	A	G	Missense_Mutation	p.L11P	1
RPS13	HNSC	chr11	17095985	17095985	C	G	Missense_Mutation		1
RPS13	LUAD	chr11	17099024	17099025	CC	AA	Splice_Site	p.G8_splice	1
RPS13	STAD	chr11	17099222	17099222	G	C	Splice_Site		1

Copy number variation (CNV) of RPS13
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS13
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
87059	N/A	BG110883	ATXN7L3B	chr12	74933276	+	RPS13	chr11	17098766	-
87059	N/A	AA573035	MRPL35	chr2	86431560	+	RPS13	chr11	17095936	+
87059	N/A	BI493904	OSTF1	chr9	77761978	+	RPS13	chr11	17095936	+
94938	STAD	TCGA-CD-A4MG	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
99610	UCEC	TCGA-EY-A2OM	RPS13	chr11	17098714	-	COL3A1	chr2	189871662	+
85419	STAD	TCGA-IN-A7NR	RPS13	chr11	17098714	-	CUL3	chr2	225368539	-
86128	N/A	AA536109	RPS13	chr11	17095936	-	GPATCH1	chr19	33579039	-
77383	N/A	BP428989	RPS13	chr11	17097000	-	HCN1	chr5	45284257	+
90628	N/A	BQ324806	RPS13	chr11	17096659	-	HDGF	chr1	156714142	-
103210	N/A	BG033756	RPS13	chr11	17095936	-	ILDR2	chr1	166934994	-
93501	N/A	AV681863	RPS13	chr11	17095936	-	MME	chr3	154748680	+
94137	OV	TCGA-24-0970	RPS13	chr11	17098714	-	PSMG3	chr7	1608996	-
103224	N/A	CB054388	RPS13	chr11	17095936	-	RASGRF1	chr15	79318269	+
98505	N/A	AX381475	RPS13	chr11	17095936	-	ROBO2	chr3	76879961	+
87059	N/A	CD240105	RPS13	chr11	17097013	-	RPS13	chr11	17095960	+
103314	N/A	EC458551	RPS13	chr11	17095996	+	TMEM54	chr1	33360345	-
101082	N/A	AX395881	RPS13	chr11	17095936	-	TSHZ2	chr20	51718929	+
103080	N/A	BI860013	RPS13	chr11	17095936	-	TTC28	chr22	28693375	-
77383	N/A	AA876942	RPS13	chr11	17095936	-	ZYG11B	chr1	53238152	-
77383	N/A	AI525777	RPS13	chr11	17095936	-	ZYG11B	chr1	53238296	-
77383	N/A	BF244367	RPS13	chr11	17095936	-	ZYG11B	chr1	53238346	-
77383	N/A	BG029513	RPS13	chr11	17095936	-	ZYG11B	chr1	53238025	-
77383	N/A	BG030773	RPS13	chr11	17095936	-	ZYG11B	chr1	53238282	-
77383	N/A	BG031097	RPS13	chr11	17095936	-	ZYG11B	chr1	53238128	-
77383	N/A	CF123537	RPS13	chr11	17095936	-	ZYG11B	chr1	53238159	-
87059	N/A	BU935289	SNRPD1	chr18	19209056	+	RPS13	chr11	17096746	-
87061	N/A	AA226238	ST8SIA5	chr18	44277087	-	RPS13	chr11	17095936	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPS13	0.0026376809695117	0.074
BLCA	RPS13	0.0484719139922483	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
PAAD	RPS13	0.0182121853425271	0.6

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source