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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS15 (NCBI Gene ID:6209)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS15
	Gene ID: 6209
	Gene Symbol	RPS15
	Gene ID	6209
	Gene Name	ribosomal protein S15
	Synonyms	RIG\|S15
	Cytomap	19p13.3
	Type of Gene	protein-coding
	Description	40S ribosomal protein S15homolog of rat insulinomainsulinoma proteinsmall ribosomal subunit protein uS19
	Modification date	20200322
	UniProtAcc	P62841

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS15[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS15	RPS15 mutations rewire RNA translation in chronic lymphocytic leukemia	34251413

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
PRAD	RPS15	2.38682220239643	0.000931746432967977
LUSC	RPS15	-1.54018132537089	0.00665527288479679
KIRC	RPS15	-1.51134139657827	6.64395189280361e-09
KIRP	RPS15	-1.53644743209735	9.0546440333128e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
READ	RPS15	3	2	0.0212406001450671	0.6231139375	0.532767466517857	-0.064524720249934	0.158302351178609
SKCM	RPS15	3	2	0.0285236034579973	0.6317912875	0.563699778761062	0.0657260797500348	-0.0762988972411133

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
DLBC	RPS15	-0.017689318	0.011485702
THYM	RPS15	0.032853683	0.018310891
ESCA	RPS15	0.021469301	0.029165692

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS15 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	RPS15	PFDN5	0.852121498	1.14E-13
CHOL	Cell metabolism gene	RPS15	SNRPD2	0.861701329	2.98E-14
CHOL	CGC	RPS15	NACA	0.862195922	2.78E-14
CHOL	Epifactor	RPS15	FBL	0.838578995	6.50E-13
CHOL	TSG	RPS15	GLTSCR2	0.818323609	6.65E-12
CHOL	TSG	RPS15	GNB2L1	0.826429536	2.72E-12
DLBC	Cell metabolism gene	RPS15	MED27	0.800432113	8.62E-12
DLBC	Cell metabolism gene	RPS15	SNRPE	0.800796139	8.30E-12
DLBC	Cell metabolism gene	RPS15	ITPA	0.800867696	8.24E-12
DLBC	Cell metabolism gene	RPS15	TIMM50	0.80420789	5.81E-12
DLBC	Cell metabolism gene	RPS15	HSD17B10	0.808661461	3.60E-12
DLBC	Cell metabolism gene	RPS15	PPP2R1A	0.808710957	3.58E-12
DLBC	Cell metabolism gene	RPS15	LSM4	0.808990949	3.47E-12
DLBC	Cell metabolism gene	RPS15	PMPCA	0.809248197	3.38E-12
DLBC	Cell metabolism gene	RPS15	DPM2	0.811379875	2.67E-12
DLBC	Cell metabolism gene	RPS15	POLR2I	0.811976553	2.50E-12
DLBC	Cell metabolism gene	RPS15	PSMD13	0.814419927	1.91E-12
DLBC	Cell metabolism gene	RPS15	POLR2L	0.814683391	1.85E-12
DLBC	Cell metabolism gene	RPS15	PTDSS2	0.818515823	1.20E-12
DLBC	Cell metabolism gene	RPS15	DOHH	0.823311106	6.82E-13
DLBC	Cell metabolism gene	RPS15	ECHS1	0.825220015	5.43E-13
DLBC	Cell metabolism gene	RPS15	PSMD4	0.826071538	4.90E-13
DLBC	Cell metabolism gene	RPS15	EXOSC4	0.828759929	3.53E-13
DLBC	Cell metabolism gene	RPS15	PSMC5	0.834337248	1.76E-13
DLBC	Cell metabolism gene	RPS15	PFDN4	0.834555482	1.71E-13
DLBC	Cell metabolism gene	RPS15	MIF	0.836998272	1.25E-13
DLBC	Cell metabolism gene	RPS15	PGLS	0.846918977	3.30E-14
DLBC	Cell metabolism gene	RPS15	POLR2F	0.847109788	3.21E-14
DLBC	Cell metabolism gene	RPS15	TIMM9	0.849327499	2.35E-14
DLBC	Cell metabolism gene	RPS15	GEMIN7	0.849448056	2.31E-14
DLBC	Cell metabolism gene	RPS15	PSMB4	0.851802579	1.65E-14
DLBC	Cell metabolism gene	RPS15	GFER	0.857792911	6.85E-15
DLBC	Cell metabolism gene	RPS15	PFDN5	0.863476567	2.86E-15
DLBC	Cell metabolism gene	RPS15	PSMB3	0.866046065	1.90E-15
DLBC	Cell metabolism gene	RPS15	TOMM22	0.866729946	1.70E-15
DLBC	Cell metabolism gene	RPS15	FAU	0.873829513	5.23E-16
DLBC	Cell metabolism gene	RPS15	TIMM13	0.875736412	3.77E-16
DLBC	Cell metabolism gene	RPS15	SNRPD2	0.902247598	2.03E-18
DLBC	Cell metabolism gene	RPS15	NME2	0.907776103	5.65E-19
DLBC	CGC	RPS15	PPP2R1A	0.808710957	3.58E-12
DLBC	CGC	RPS15	HRAS	0.817198947	1.39E-12
DLBC	CGC	RPS15	NACA	0.8286919	3.56E-13
DLBC	CGC	RPS15	MAP2K2	0.830605107	2.81E-13
DLBC	CGC	RPS15	NTHL1	0.851799441	1.65E-14
DLBC	Epifactor	RPS15	PPP4C	0.807554018	4.06E-12
DLBC	Epifactor	RPS15	DMAP1	0.808896509	3.51E-12
DLBC	Epifactor	RPS15	PELP1	0.80892259	3.50E-12
DLBC	Epifactor	RPS15	RBX1	0.809585452	3.26E-12
DLBC	Epifactor	RPS15	ZNHIT1	0.81144329	2.66E-12
DLBC	Epifactor	RPS15	TAF10	0.813747084	2.06E-12
DLBC	Epifactor	RPS15	SIRT6	0.819752398	1.04E-12
DLBC	Epifactor	RPS15	EXOSC4	0.828759929	3.53E-13
DLBC	Epifactor	RPS15	PRPF31	0.83288466	2.11E-13
DLBC	Epifactor	RPS15	MBD3	0.832990045	2.09E-13
DLBC	Epifactor	RPS15	FBL	0.848911694	2.50E-14
DLBC	IUPHAR	RPS15	SLC25A39	0.800682611	8.40E-12
DLBC	IUPHAR	RPS15	HRAS	0.817198947	1.39E-12
DLBC	IUPHAR	RPS15	SIRT6	0.819752398	1.04E-12
DLBC	IUPHAR	RPS15	MAP2K2	0.830605107	2.81E-13
DLBC	IUPHAR	RPS15	MFSD2B	0.833820807	1.88E-13
DLBC	Kinase	RPS15	MAP2K2	0.830605107	2.81E-13
DLBC	TF	RPS15	IRF3	0.801884599	7.41E-12
DLBC	TF	RPS15	ZNF428	0.807118941	4.26E-12
DLBC	TF	RPS15	MBD3	0.832990045	2.09E-13
DLBC	TF	RPS15	ZNF581	0.833193242	2.03E-13
DLBC	TF	RPS15	THAP4	0.8426298	5.93E-14
DLBC	TF	RPS15	THAP3	0.84493434	4.34E-14
DLBC	TF	RPS15	THAP7	0.852953119	1.40E-14
DLBC	TF	RPS15	ZNF444	0.858928667	5.77E-15
DLBC	TF	RPS15	NME2	0.907776103	5.65E-19
DLBC	TSG	RPS15	IRF3	0.801884599	7.41E-12
DLBC	TSG	RPS15	SIRT6	0.819752398	1.04E-12
DLBC	TSG	RPS15	GLTSCR2	0.827846645	3.95E-13
DLBC	TSG	RPS15	TSSC4	0.828767137	3.53E-13
DLBC	TSG	RPS15	PARK7	0.837802369	1.13E-13
DLBC	TSG	RPS15	GNB2L1	0.897288205	5.99E-18
DLBC	TSG	RPS15	GADD45GIP1	0.906088084	8.41E-19
GBM	Cell metabolism gene	RPS15	SNRPD2	0.810881435	2.08E-41
GBM	Cell metabolism gene	RPS15	FAU	0.812122923	1.26E-41
GBM	Cell metabolism gene	RPS15	TIMM13	0.825576099	4.20E-44
GBM	TSG	RPS15	GADD45GIP1	0.852674979	8.33E-50
HNSC	Cell metabolism gene	RPS15	TIMM13	0.820557987	3.94E-139
KICH	Cell metabolism gene	RPS15	SNRPB	0.849458147	1.92E-26
KICH	Cell metabolism gene	RPS15	PGLS	0.854815131	4.34E-27
KICH	Cell metabolism gene	RPS15	SNRPD2	0.863433701	3.47E-28
KICH	TF	RPS15	ZNF581	0.829043441	3.45E-24
KICH	TSG	RPS15	GADD45GIP1	0.840856489	1.87E-25
KICH	TSG	RPS15	GLTSCR2	0.852164193	9.13E-27
KIRP	Cell metabolism gene	RPS15	SNRPD2	0.835249753	2.24E-85
KIRP	Cell metabolism gene	RPS15	POLR2I	0.844030434	7.25E-89
KIRP	Cell metabolism gene	RPS15	PGLS	0.868174957	1.08E-99
KIRP	Cell metabolism gene	RPS15	FAU	0.904879747	4.20E-121
KIRP	CGC	RPS15	MAP2K2	0.843162603	1.64E-88
KIRP	Epifactor	RPS15	SIRT6	0.809377957	3.47E-76
KIRP	IUPHAR	RPS15	SIRT6	0.809377957	3.47E-76
KIRP	IUPHAR	RPS15	MAP2K2	0.843162603	1.64E-88
KIRP	Kinase	RPS15	MAP2K2	0.843162603	1.64E-88
KIRP	TF	RPS15	ZNF787	0.806478773	3.04E-75
KIRP	TF	RPS15	ZNF358	0.820047907	8.51E-80
KIRP	TF	RPS15	DRAP1	0.821583974	2.46E-80
KIRP	TSG	RPS15	GLTSCR2	0.808051528	9.41E-76
KIRP	TSG	RPS15	SIRT6	0.809377957	3.47E-76
KIRP	TSG	RPS15	GADD45GIP1	0.865868541	1.43E-98
LAML	Cell metabolism gene	RPS15	FAU	0.828578549	6.15E-45
LGG	Epifactor	RPS15	SIRT6	0.803817161	3.41E-121
LGG	Epifactor	RPS15	PKN1	0.813963304	1.21E-126
LGG	IUPHAR	RPS15	SIRT6	0.803817161	3.41E-121
LGG	IUPHAR	RPS15	PKN1	0.813963304	1.21E-126
LGG	Kinase	RPS15	PKN1	0.813963304	1.21E-126
LGG	TSG	RPS15	SIRT6	0.803817161	3.41E-121
LIHC	TSG	RPS15	GADD45GIP1	0.849190341	8.30E-119
MESO	Cell metabolism gene	RPS15	FAU	0.823529769	1.23E-22
PAAD	Cell metabolism gene	RPS15	TIMM13	0.814818253	1.01E-44
PAAD	CGC	RPS15	MAP2K2	0.822200927	3.62E-46
PAAD	IUPHAR	RPS15	MAP2K2	0.822200927	3.62E-46
PAAD	Kinase	RPS15	MAP2K2	0.822200927	3.62E-46
PAAD	TSG	RPS15	GLTSCR2	0.809881911	8.55E-44
PAAD	TSG	RPS15	GADD45GIP1	0.812950468	2.28E-44
PCPG	Cell metabolism gene	RPS15	PGLS	0.80523997	7.39E-44
PCPG	Cell metabolism gene	RPS15	FAU	0.839928937	5.44E-51
PCPG	Cell metabolism gene	RPS15	PFDN5	0.84143621	2.44E-51
PCPG	CGC	RPS15	MAP2K2	0.842860913	1.14E-51
PCPG	Epifactor	RPS15	SIRT6	0.821407305	5.46E-47
PCPG	IUPHAR	RPS15	SIRT6	0.821407305	5.46E-47
PCPG	IUPHAR	RPS15	MAP2K2	0.842860913	1.14E-51
PCPG	Kinase	RPS15	MAP2K2	0.842860913	1.14E-51
PCPG	TF	RPS15	ZNF524	0.817120494	3.96E-46
PCPG	TF	RPS15	ZNF358	0.850016239	2.16E-53
PCPG	TSG	RPS15	SIRT6	0.821407305	5.46E-47
PRAD	Cell metabolism gene	RPS15	NME2	0.800175403	9.18E-124
PRAD	Cell metabolism gene	RPS15	GPX4	0.804935349	2.54E-126
PRAD	Cell metabolism gene	RPS15	MPST	0.830733164	1.59E-141
PRAD	Cell metabolism gene	RPS15	NME3	0.837859559	3.47E-146
PRAD	Cell metabolism gene	RPS15	POLR2F	0.844352708	1.24E-150
PRAD	Cell metabolism gene	RPS15	PSMB7	0.851362312	1.14E-155
PRAD	Cell metabolism gene	RPS15	SNRPD2	0.862581429	2.71E-164
PRAD	Cell metabolism gene	RPS15	TIMM13	0.870209368	1.32E-170
PRAD	Cell metabolism gene	RPS15	POLR2I	0.870768031	4.38E-171
PRAD	Cell metabolism gene	RPS15	FAU	0.872805381	7.56E-173
PRAD	Cell metabolism gene	RPS15	PGLS	0.873525089	1.77E-173
PRAD	CGC	RPS15	MAP2K2	0.829729153	6.91E-141
PRAD	Epifactor	RPS15	RUVBL2	0.801145203	2.80E-124
PRAD	Epifactor	RPS15	INO80B	0.803249668	2.09E-125
PRAD	Epifactor	RPS15	FBL	0.815228271	4.23E-132
PRAD	Epifactor	RPS15	SIRT6	0.815690569	2.28E-132
PRAD	Epifactor	RPS15	MBD3	0.827485343	1.79E-139
PRAD	IUPHAR	RPS15	NR2F6	0.815355808	3.57E-132
PRAD	IUPHAR	RPS15	SIRT6	0.815690569	2.28E-132
PRAD	IUPHAR	RPS15	MAP2K2	0.829729153	6.91E-141
PRAD	IUPHAR	RPS15	MPST	0.830733164	1.59E-141
PRAD	Kinase	RPS15	MAP2K2	0.829729153	6.91E-141
PRAD	TF	RPS15	NME2	0.800175403	9.18E-124
PRAD	TF	RPS15	THAP3	0.808458959	2.93E-128
PRAD	TF	RPS15	NR2F6	0.815355808	3.57E-132
PRAD	TF	RPS15	ZNF205	0.824932665	6.85E-138
PRAD	TF	RPS15	MBD3	0.827485343	1.79E-139
PRAD	TF	RPS15	ZNF358	0.836390593	3.31E-145
PRAD	TF	RPS15	ZNF579	0.840555426	5.23E-148
PRAD	TF	RPS15	ZNF524	0.880738697	5.18E-180
PRAD	TSG	RPS15	GLTSCR2	0.813617845	3.58E-131
PRAD	TSG	RPS15	SIRT6	0.815690569	2.28E-132
PRAD	TSG	RPS15	GNB2L1	0.824369495	1.52E-137
PRAD	TSG	RPS15	GADD45GIP1	0.843127593	8.87E-150
READ	TSG	RPS15	GADD45GIP1	0.828112231	1.21E-27
TGCT	Cell metabolism gene	RPS15	SNRPD2	0.831758626	3.34E-41
TGCT	Cell metabolism gene	RPS15	POLR2I	0.845179099	9.58E-44
TGCT	TSG	RPS15	GADD45GIP1	0.842171864	3.73E-43
THCA	Cell metabolism gene	RPS15	MIF	0.801177883	3.28E-129
THCA	Cell metabolism gene	RPS15	GPX4	0.806800712	2.23E-132
THCA	Cell metabolism gene	RPS15	TBCB	0.807212254	1.29E-132
THCA	Cell metabolism gene	RPS15	DOHH	0.811804688	2.75E-135
THCA	Cell metabolism gene	RPS15	SNRPD2	0.841614975	1.25E-154
THCA	Cell metabolism gene	RPS15	POLR2I	0.849237051	3.17E-160
THCA	Cell metabolism gene	RPS15	FAU	0.877673196	3.20E-184
THCA	Cell metabolism gene	RPS15	PGLS	0.883662684	4.82E-190
THCA	CGC	RPS15	MAP2K2	0.890526091	4.01E-197
THCA	Epifactor	RPS15	HMG20B	0.810464845	1.68E-134
THCA	Epifactor	RPS15	SIRT6	0.816653017	3.44E-138
THCA	Epifactor	RPS15	TAF10	0.844256444	1.56E-156
THCA	IUPHAR	RPS15	SIRT6	0.816653017	3.44E-138
THCA	IUPHAR	RPS15	MAP2K2	0.890526091	4.01E-197
THCA	Kinase	RPS15	MAP2K2	0.890526091	4.01E-197
THCA	TF	RPS15	ZNF688	0.809803384	4.10E-134
THCA	TF	RPS15	HMG20B	0.810464845	1.68E-134
THCA	TF	RPS15	ZNF579	0.812904782	6.14E-136
THCA	TF	RPS15	ZNF358	0.845689479	1.39E-157
THCA	TF	RPS15	ZNF524	0.8576576	8.82E-167
THCA	TSG	RPS15	AIP	0.803431265	1.81E-130
THCA	TSG	RPS15	SIRT6	0.816653017	3.44E-138
THCA	TSG	RPS15	GLTSCR2	0.826088481	4.30E-144
THCA	TSG	RPS15	GADD45GIP1	0.859359284	3.71E-168
THYM	Cell metabolism gene	RPS15	NME2	0.801857668	1.31E-28
THYM	Cell metabolism gene	RPS15	GSTP1	0.803074435	9.41E-29
THYM	Cell metabolism gene	RPS15	GEMIN6	0.804930175	5.66E-29
THYM	Cell metabolism gene	RPS15	SSR4	0.80777913	2.56E-29
THYM	Cell metabolism gene	RPS15	HMOX2	0.810458346	1.20E-29
THYM	Cell metabolism gene	RPS15	GSTZ1	0.811799268	8.20E-30
THYM	Cell metabolism gene	RPS15	TOMM7	0.812461126	6.78E-30
THYM	Cell metabolism gene	RPS15	TIMM17B	0.813032255	5.75E-30
THYM	Cell metabolism gene	RPS15	OAZ1	0.813149413	5.56E-30
THYM	Cell metabolism gene	RPS15	PHKG2	0.813751543	4.67E-30
THYM	Cell metabolism gene	RPS15	PPCDC	0.816054434	2.38E-30
THYM	Cell metabolism gene	RPS15	PSMC1	0.817459945	1.57E-30
THYM	Cell metabolism gene	RPS15	MPST	0.817770083	1.43E-30
THYM	Cell metabolism gene	RPS15	PSMC3	0.818992885	9.95E-31
THYM	Cell metabolism gene	RPS15	MVD	0.820174268	6.98E-31
THYM	Cell metabolism gene	RPS15	TOMM22	0.820466903	6.39E-31
THYM	Cell metabolism gene	RPS15	LCMT1	0.820561165	6.21E-31
THYM	Cell metabolism gene	RPS15	DOHH	0.820579364	6.17E-31
THYM	Cell metabolism gene	RPS15	ATP5G1	0.82097118	5.48E-31
THYM	Cell metabolism gene	RPS15	SNRPD3	0.823633109	2.43E-31
THYM	Cell metabolism gene	RPS15	PSMC5	0.829200063	4.23E-32
THYM	Cell metabolism gene	RPS15	GFER	0.82921141	4.21E-32
THYM	Cell metabolism gene	RPS15	HSD17B10	0.829594915	3.73E-32
THYM	Cell metabolism gene	RPS15	HMBS	0.830852571	2.49E-32
THYM	Cell metabolism gene	RPS15	PMPCA	0.831252829	2.18E-32
THYM	Cell metabolism gene	RPS15	PSME2	0.832506287	1.45E-32
THYM	Cell metabolism gene	RPS15	NANS	0.83300091	1.24E-32
THYM	Cell metabolism gene	RPS15	EBP	0.835144658	6.09E-33
THYM	Cell metabolism gene	RPS15	ALG3	0.835723858	5.02E-33
THYM	Cell metabolism gene	RPS15	TBCB	0.838069216	2.28E-33
THYM	Cell metabolism gene	RPS15	WBSCR22	0.838111169	2.25E-33
THYM	Cell metabolism gene	RPS15	SRM	0.838831229	1.76E-33
THYM	Cell metabolism gene	RPS15	TOMM40	0.838856574	1.75E-33
THYM	Cell metabolism gene	RPS15	PSMD4	0.846379606	1.26E-34
THYM	Cell metabolism gene	RPS15	PTGES2	0.846937843	1.03E-34
THYM	Cell metabolism gene	RPS15	GEMIN7	0.847955039	7.10E-35
THYM	Cell metabolism gene	RPS15	SSR2	0.848233679	6.42E-35
THYM	Cell metabolism gene	RPS15	POLE4	0.852331458	1.41E-35
THYM	Cell metabolism gene	RPS15	TIMM10	0.852556668	1.30E-35
THYM	Cell metabolism gene	RPS15	IDH3G	0.854598444	5.99E-36
THYM	Cell metabolism gene	RPS15	PHPT1	0.856852303	2.52E-36
THYM	Cell metabolism gene	RPS15	PSMB7	0.860463007	6.08E-37
THYM	Cell metabolism gene	RPS15	SLC27A5	0.863183835	2.03E-37
THYM	Cell metabolism gene	RPS15	GMPPA	0.864974607	9.74E-38
THYM	Cell metabolism gene	RPS15	EXOSC5	0.865400083	8.17E-38
THYM	Cell metabolism gene	RPS15	ACOT8	0.867360955	3.60E-38
THYM	Cell metabolism gene	RPS15	ITPA	0.869157189	1.68E-38
THYM	Cell metabolism gene	RPS15	GUK1	0.869410865	1.51E-38
THYM	Cell metabolism gene	RPS15	POLR2H	0.871699431	5.60E-39
THYM	Cell metabolism gene	RPS15	POLR2J	0.874482042	1.64E-39
THYM	Cell metabolism gene	RPS15	PSMB3	0.8754577	1.06E-39
THYM	Cell metabolism gene	RPS15	MTX1	0.876379447	6.96E-40
THYM	Cell metabolism gene	RPS15	TIMM8B	0.876599138	6.29E-40
THYM	Cell metabolism gene	RPS15	POLR2F	0.878468119	2.67E-40
THYM	Cell metabolism gene	RPS15	PFDN5	0.88409287	1.85E-41
THYM	Cell metabolism gene	RPS15	APRT	0.884383717	1.60E-41
THYM	Cell metabolism gene	RPS15	MIF	0.890585079	7.10E-43
THYM	Cell metabolism gene	RPS15	DPM3	0.893048851	1.95E-43
THYM	Cell metabolism gene	RPS15	EXOSC4	0.893207261	1.79E-43
THYM	Cell metabolism gene	RPS15	DPM2	0.897541503	1.71E-44
THYM	Cell metabolism gene	RPS15	SNRPD2	0.90160772	1.70E-45
THYM	Cell metabolism gene	RPS15	TIMM13	0.905008212	2.29E-46
THYM	Cell metabolism gene	RPS15	FAU	0.905143658	2.11E-46
THYM	Cell metabolism gene	RPS15	TIMM50	0.914650114	4.98E-49
THYM	Cell metabolism gene	RPS15	PGLS	0.932207491	8.42E-55
THYM	Cell metabolism gene	RPS15	POLR2I	0.934010409	1.76E-55
THYM	CGC	RPS15	SDHAF2	0.800069999	2.12E-28
THYM	CGC	RPS15	MGMT	0.816880531	1.87E-30
THYM	CGC	RPS15	MAP2K2	0.81702918	1.79E-30
THYM	CGC	RPS15	ASPSCR1	0.843489422	3.51E-34
THYM	CGC	RPS15	RBM10	0.846931113	1.03E-34
THYM	CGC	RPS15	TFPT	0.850525104	2.77E-35
THYM	Epifactor	RPS15	PPP4C	0.806634071	3.53E-29
THYM	Epifactor	RPS15	PELP1	0.810492253	1.19E-29
THYM	Epifactor	RPS15	INO80B	0.812107069	7.51E-30
THYM	Epifactor	RPS15	ZGPAT	0.81318271	5.51E-30
THYM	Epifactor	RPS15	NOC2L	0.814968237	3.28E-30
THYM	Epifactor	RPS15	RUVBL2	0.815726297	2.62E-30
THYM	Epifactor	RPS15	PAF1	0.822989018	2.96E-31
THYM	Epifactor	RPS15	PRMT1	0.833433401	1.07E-32
THYM	Epifactor	RPS15	CCDC101	0.838254519	2.14E-33
THYM	Epifactor	RPS15	C17orf49	0.842231738	5.45E-34
THYM	Epifactor	RPS15	MBD3	0.844336251	2.60E-34
THYM	Epifactor	RPS15	INO80E	0.84631488	1.28E-34
THYM	Epifactor	RPS15	TFPT	0.850525104	2.77E-35
THYM	Epifactor	RPS15	LAS1L	0.853206172	1.02E-35
THYM	Epifactor	RPS15	EXOSC5	0.865400083	8.17E-38
THYM	Epifactor	RPS15	BRMS1	0.885185691	1.08E-41
THYM	Epifactor	RPS15	TAF10	0.889628929	1.16E-42
THYM	Epifactor	RPS15	FBL	0.891346129	4.78E-43
THYM	Epifactor	RPS15	EXOSC4	0.893207261	1.79E-43
THYM	Epifactor	RPS15	PRPF31	0.899544866	5.54E-45
THYM	Epifactor	RPS15	ZNHIT1	0.903433579	5.84E-46
THYM	Epifactor	RPS15	SIRT6	0.905985849	1.27E-46
THYM	IUPHAR	RPS15	MMP24	0.801280134	1.53E-28
THYM	IUPHAR	RPS15	HMOX2	0.810458346	1.20E-29
THYM	IUPHAR	RPS15	ATP6V0B	0.810964209	1.04E-29
THYM	IUPHAR	RPS15	PHKG2	0.813751543	4.67E-30
THYM	IUPHAR	RPS15	MAP2K2	0.81702918	1.79E-30
THYM	IUPHAR	RPS15	MPST	0.817770083	1.43E-30
THYM	IUPHAR	RPS15	MVD	0.820174268	6.98E-31
THYM	IUPHAR	RPS15	EGLN2	0.823024555	2.93E-31
THYM	IUPHAR	RPS15	SIRT3	0.832340988	1.53E-32
THYM	IUPHAR	RPS15	PRMT1	0.833433401	1.07E-32
THYM	IUPHAR	RPS15	PTGES2	0.846937843	1.03E-34
THYM	IUPHAR	RPS15	SLC27A5	0.863183835	2.03E-37
THYM	IUPHAR	RPS15	SIRT6	0.905985849	1.27E-46
THYM	Kinase	RPS15	PHKG2	0.813751543	4.67E-30
THYM	Kinase	RPS15	FASTK	0.814426633	3.84E-30
THYM	Kinase	RPS15	MAP2K2	0.81702918	1.79E-30
THYM	TF	RPS15	NME2	0.801857668	1.31E-28
THYM	TF	RPS15	USF1	0.802469577	1.11E-28
THYM	TF	RPS15	ZBTB48	0.806883862	3.29E-29
THYM	TF	RPS15	ZGPAT	0.81318271	5.51E-30
THYM	TF	RPS15	ETV2	0.814039801	4.30E-30
THYM	TF	RPS15	CENPB	0.814912754	3.33E-30
THYM	TF	RPS15	REXO4	0.815395779	2.89E-30
THYM	TF	RPS15	DRAP1	0.815678394	2.66E-30
THYM	TF	RPS15	IRF3	0.816497486	2.09E-30
THYM	TF	RPS15	ZNF32	0.83028045	2.99E-32
THYM	TF	RPS15	ZNF580	0.838849303	1.75E-33
THYM	TF	RPS15	THAP3	0.841572859	6.86E-34
THYM	TF	RPS15	MBD3	0.844336251	2.60E-34
THYM	TF	RPS15	ZNF428	0.846927423	1.03E-34
THYM	TF	RPS15	GLI4	0.854580225	6.03E-36
THYM	TF	RPS15	ZNF688	0.86071901	5.49E-37
THYM	TF	RPS15	ZNF524	0.89546115	5.35E-44
THYM	TF	RPS15	ZNF581	0.896354565	3.28E-44
THYM	TF	RPS15	ZNF787	0.902627468	9.39E-46
THYM	TF	RPS15	THAP7	0.905213291	2.02E-46
THYM	TSG	RPS15	GSTP1	0.803074435	9.41E-29
THYM	TSG	RPS15	ZBTB48	0.806883862	3.29E-29
THYM	TSG	RPS15	PYCARD	0.813566673	4.93E-30
THYM	TSG	RPS15	IRF3	0.816497486	2.09E-30
THYM	TSG	RPS15	PARK7	0.820961352	5.50E-31
THYM	TSG	RPS15	SIRT3	0.832340988	1.53E-32
THYM	TSG	RPS15	GABARAP	0.842560093	4.86E-34
THYM	TSG	RPS15	STUB1	0.851061646	2.27E-35
THYM	TSG	RPS15	GLTSCR2	0.851257682	2.11E-35
THYM	TSG	RPS15	GNB2L1	0.852650923	1.25E-35
THYM	TSG	RPS15	NPRL2	0.867035209	4.13E-38
THYM	TSG	RPS15	TSSC4	0.878851113	2.23E-40
THYM	TSG	RPS15	BRMS1	0.885185691	1.08E-41
THYM	TSG	RPS15	SIRT6	0.905985849	1.27E-46
THYM	TSG	RPS15	GADD45GIP1	0.929690972	6.96E-54
UCEC	CGC	RPS15	MAP2K2	0.836071196	8.79E-54
UCEC	IUPHAR	RPS15	MAP2K2	0.836071196	8.79E-54
UCEC	Kinase	RPS15	MAP2K2	0.836071196	8.79E-54
UCS	Cell metabolism gene	RPS15	NME2	0.801857668	1.31E-28
UCS	Cell metabolism gene	RPS15	GSTP1	0.803074435	9.41E-29
UCS	Cell metabolism gene	RPS15	GEMIN6	0.804930175	5.66E-29
UCS	Cell metabolism gene	RPS15	SSR4	0.80777913	2.56E-29
UCS	Cell metabolism gene	RPS15	HMOX2	0.810458346	1.20E-29
UCS	Cell metabolism gene	RPS15	GSTZ1	0.811799268	8.20E-30
UCS	Cell metabolism gene	RPS15	TOMM7	0.812461126	6.78E-30
UCS	Cell metabolism gene	RPS15	TIMM17B	0.813032255	5.75E-30
UCS	Cell metabolism gene	RPS15	OAZ1	0.813149413	5.56E-30
UCS	Cell metabolism gene	RPS15	PHKG2	0.813751543	4.67E-30
UCS	Cell metabolism gene	RPS15	PPCDC	0.816054434	2.38E-30
UCS	Cell metabolism gene	RPS15	PSMC1	0.817459945	1.57E-30
UCS	Cell metabolism gene	RPS15	MPST	0.817770083	1.43E-30
UCS	Cell metabolism gene	RPS15	PSMC3	0.818992885	9.95E-31
UCS	Cell metabolism gene	RPS15	MVD	0.820174268	6.98E-31
UCS	Cell metabolism gene	RPS15	TOMM22	0.820466903	6.39E-31
UCS	Cell metabolism gene	RPS15	LCMT1	0.820561165	6.21E-31
UCS	Cell metabolism gene	RPS15	DOHH	0.820579364	6.17E-31
UCS	Cell metabolism gene	RPS15	ATP5G1	0.82097118	5.48E-31
UCS	Cell metabolism gene	RPS15	SNRPD3	0.823633109	2.43E-31
UCS	Cell metabolism gene	RPS15	PSMC5	0.829200063	4.23E-32
UCS	Cell metabolism gene	RPS15	GFER	0.82921141	4.21E-32
UCS	Cell metabolism gene	RPS15	HSD17B10	0.829594915	3.73E-32
UCS	Cell metabolism gene	RPS15	HMBS	0.830852571	2.49E-32
UCS	Cell metabolism gene	RPS15	PMPCA	0.831252829	2.18E-32
UCS	Cell metabolism gene	RPS15	PSME2	0.832506287	1.45E-32
UCS	Cell metabolism gene	RPS15	NANS	0.83300091	1.24E-32
UCS	Cell metabolism gene	RPS15	EBP	0.835144658	6.09E-33
UCS	Cell metabolism gene	RPS15	ALG3	0.835723858	5.02E-33
UCS	Cell metabolism gene	RPS15	TBCB	0.838069216	2.28E-33
UCS	Cell metabolism gene	RPS15	WBSCR22	0.838111169	2.25E-33
UCS	Cell metabolism gene	RPS15	SRM	0.838831229	1.76E-33
UCS	Cell metabolism gene	RPS15	TOMM40	0.838856574	1.75E-33
UCS	Cell metabolism gene	RPS15	PSMD4	0.846379606	1.26E-34
UCS	Cell metabolism gene	RPS15	PTGES2	0.846937843	1.03E-34
UCS	Cell metabolism gene	RPS15	GEMIN7	0.847955039	7.10E-35
UCS	Cell metabolism gene	RPS15	SSR2	0.848233679	6.42E-35
UCS	Cell metabolism gene	RPS15	POLE4	0.852331458	1.41E-35
UCS	Cell metabolism gene	RPS15	TIMM10	0.852556668	1.30E-35
UCS	Cell metabolism gene	RPS15	IDH3G	0.854598444	5.99E-36
UCS	Cell metabolism gene	RPS15	PHPT1	0.856852303	2.52E-36
UCS	Cell metabolism gene	RPS15	PSMB7	0.860463007	6.08E-37
UCS	Cell metabolism gene	RPS15	SLC27A5	0.863183835	2.03E-37
UCS	Cell metabolism gene	RPS15	GMPPA	0.864974607	9.74E-38
UCS	Cell metabolism gene	RPS15	EXOSC5	0.865400083	8.17E-38
UCS	Cell metabolism gene	RPS15	ACOT8	0.867360955	3.60E-38
UCS	Cell metabolism gene	RPS15	ITPA	0.869157189	1.68E-38
UCS	Cell metabolism gene	RPS15	GUK1	0.869410865	1.51E-38
UCS	Cell metabolism gene	RPS15	POLR2H	0.871699431	5.60E-39
UCS	Cell metabolism gene	RPS15	POLR2J	0.874482042	1.64E-39
UCS	Cell metabolism gene	RPS15	PSMB3	0.8754577	1.06E-39
UCS	Cell metabolism gene	RPS15	MTX1	0.876379447	6.96E-40
UCS	Cell metabolism gene	RPS15	TIMM8B	0.876599138	6.29E-40
UCS	Cell metabolism gene	RPS15	POLR2F	0.878468119	2.67E-40
UCS	Cell metabolism gene	RPS15	PFDN5	0.88409287	1.85E-41
UCS	Cell metabolism gene	RPS15	APRT	0.884383717	1.60E-41
UCS	Cell metabolism gene	RPS15	MIF	0.890585079	7.10E-43
UCS	Cell metabolism gene	RPS15	DPM3	0.893048851	1.95E-43
UCS	Cell metabolism gene	RPS15	EXOSC4	0.893207261	1.79E-43
UCS	Cell metabolism gene	RPS15	DPM2	0.897541503	1.71E-44
UCS	Cell metabolism gene	RPS15	SNRPD2	0.90160772	1.70E-45
UCS	Cell metabolism gene	RPS15	TIMM13	0.905008212	2.29E-46
UCS	Cell metabolism gene	RPS15	FAU	0.905143658	2.11E-46
UCS	Cell metabolism gene	RPS15	TIMM50	0.914650114	4.98E-49
UCS	Cell metabolism gene	RPS15	PGLS	0.932207491	8.42E-55
UCS	Cell metabolism gene	RPS15	POLR2I	0.934010409	1.76E-55
UCS	CGC	RPS15	SDHAF2	0.800069999	2.12E-28
UCS	CGC	RPS15	MGMT	0.816880531	1.87E-30
UCS	CGC	RPS15	MAP2K2	0.81702918	1.79E-30
UCS	CGC	RPS15	ASPSCR1	0.843489422	3.51E-34
UCS	CGC	RPS15	RBM10	0.846931113	1.03E-34
UCS	CGC	RPS15	TFPT	0.850525104	2.77E-35
UCS	Epifactor	RPS15	PPP4C	0.806634071	3.53E-29
UCS	Epifactor	RPS15	PELP1	0.810492253	1.19E-29
UCS	Epifactor	RPS15	INO80B	0.812107069	7.51E-30
UCS	Epifactor	RPS15	ZGPAT	0.81318271	5.51E-30
UCS	Epifactor	RPS15	NOC2L	0.814968237	3.28E-30
UCS	Epifactor	RPS15	RUVBL2	0.815726297	2.62E-30
UCS	Epifactor	RPS15	PAF1	0.822989018	2.96E-31
UCS	Epifactor	RPS15	PRMT1	0.833433401	1.07E-32
UCS	Epifactor	RPS15	CCDC101	0.838254519	2.14E-33
UCS	Epifactor	RPS15	C17orf49	0.842231738	5.45E-34
UCS	Epifactor	RPS15	MBD3	0.844336251	2.60E-34
UCS	Epifactor	RPS15	INO80E	0.84631488	1.28E-34
UCS	Epifactor	RPS15	TFPT	0.850525104	2.77E-35
UCS	Epifactor	RPS15	LAS1L	0.853206172	1.02E-35
UCS	Epifactor	RPS15	EXOSC5	0.865400083	8.17E-38
UCS	Epifactor	RPS15	BRMS1	0.885185691	1.08E-41
UCS	Epifactor	RPS15	TAF10	0.889628929	1.16E-42
UCS	Epifactor	RPS15	FBL	0.891346129	4.78E-43
UCS	Epifactor	RPS15	EXOSC4	0.893207261	1.79E-43
UCS	Epifactor	RPS15	PRPF31	0.899544866	5.54E-45
UCS	Epifactor	RPS15	ZNHIT1	0.903433579	5.84E-46
UCS	Epifactor	RPS15	SIRT6	0.905985849	1.27E-46
UCS	IUPHAR	RPS15	MMP24	0.801280134	1.53E-28
UCS	IUPHAR	RPS15	HMOX2	0.810458346	1.20E-29
UCS	IUPHAR	RPS15	ATP6V0B	0.810964209	1.04E-29
UCS	IUPHAR	RPS15	PHKG2	0.813751543	4.67E-30
UCS	IUPHAR	RPS15	MAP2K2	0.81702918	1.79E-30
UCS	IUPHAR	RPS15	MPST	0.817770083	1.43E-30
UCS	IUPHAR	RPS15	MVD	0.820174268	6.98E-31
UCS	IUPHAR	RPS15	EGLN2	0.823024555	2.93E-31
UCS	IUPHAR	RPS15	SIRT3	0.832340988	1.53E-32
UCS	IUPHAR	RPS15	PRMT1	0.833433401	1.07E-32
UCS	IUPHAR	RPS15	PTGES2	0.846937843	1.03E-34
UCS	IUPHAR	RPS15	SLC27A5	0.863183835	2.03E-37
UCS	IUPHAR	RPS15	SIRT6	0.905985849	1.27E-46
UCS	Kinase	RPS15	PHKG2	0.813751543	4.67E-30
UCS	Kinase	RPS15	FASTK	0.814426633	3.84E-30
UCS	Kinase	RPS15	MAP2K2	0.81702918	1.79E-30
UCS	TF	RPS15	NME2	0.801857668	1.31E-28
UCS	TF	RPS15	USF1	0.802469577	1.11E-28
UCS	TF	RPS15	ZBTB48	0.806883862	3.29E-29
UCS	TF	RPS15	ZGPAT	0.81318271	5.51E-30
UCS	TF	RPS15	ETV2	0.814039801	4.30E-30
UCS	TF	RPS15	CENPB	0.814912754	3.33E-30
UCS	TF	RPS15	REXO4	0.815395779	2.89E-30
UCS	TF	RPS15	DRAP1	0.815678394	2.66E-30
UCS	TF	RPS15	IRF3	0.816497486	2.09E-30
UCS	TF	RPS15	ZNF32	0.83028045	2.99E-32
UCS	TF	RPS15	ZNF580	0.838849303	1.75E-33
UCS	TF	RPS15	THAP3	0.841572859	6.86E-34
UCS	TF	RPS15	MBD3	0.844336251	2.60E-34
UCS	TF	RPS15	ZNF428	0.846927423	1.03E-34
UCS	TF	RPS15	GLI4	0.854580225	6.03E-36
UCS	TF	RPS15	ZNF688	0.86071901	5.49E-37
UCS	TF	RPS15	ZNF524	0.89546115	5.35E-44
UCS	TF	RPS15	ZNF581	0.896354565	3.28E-44
UCS	TF	RPS15	ZNF787	0.902627468	9.39E-46
UCS	TF	RPS15	THAP7	0.905213291	2.02E-46
UCS	TSG	RPS15	GSTP1	0.803074435	9.41E-29
UCS	TSG	RPS15	ZBTB48	0.806883862	3.29E-29
UCS	TSG	RPS15	PYCARD	0.813566673	4.93E-30
UCS	TSG	RPS15	IRF3	0.816497486	2.09E-30
UCS	TSG	RPS15	PARK7	0.820961352	5.50E-31
UCS	TSG	RPS15	SIRT3	0.832340988	1.53E-32
UCS	TSG	RPS15	GABARAP	0.842560093	4.86E-34
UCS	TSG	RPS15	STUB1	0.851061646	2.27E-35
UCS	TSG	RPS15	GLTSCR2	0.851257682	2.11E-35
UCS	TSG	RPS15	GNB2L1	0.852650923	1.25E-35
UCS	TSG	RPS15	NPRL2	0.867035209	4.13E-38
UCS	TSG	RPS15	TSSC4	0.878851113	2.23E-40
UCS	TSG	RPS15	BRMS1	0.885185691	1.08E-41
UCS	TSG	RPS15	SIRT6	0.905985849	1.27E-46
UCS	TSG	RPS15	GADD45GIP1	0.929690972	6.96E-54
UVM	Cell metabolism gene	RPS15	MPST	0.844418733	7.60E-23
UVM	Cell metabolism gene	RPS15	SSR2	0.885018578	1.28E-27
UVM	Cell metabolism gene	RPS15	FAU	0.91609518	1.08E-32
UVM	CGC	RPS15	TRAF7	0.800910035	4.73E-19
UVM	Epifactor	RPS15	TRIM28	0.854554069	6.72E-24
UVM	Epifactor	RPS15	FBL	0.917166869	6.68E-33
UVM	IUPHAR	RPS15	MPST	0.844418733	7.60E-23
UVM	IUPHAR	RPS15	TRIM28	0.854554069	6.72E-24
UVM	Kinase	RPS15	TRIM28	0.854554069	6.72E-24
UVM	TF	RPS15	ZNF205	0.81045767	8.46E-20
UVM	TF	RPS15	ZNF358	0.817322225	2.31E-20
UVM	TF	RPS15	ZNF524	0.831981571	1.19E-21
UVM	TF	RPS15	ZNF581	0.881692609	3.65E-27
UVM	TSG	RPS15	GNB2L1	0.887178795	6.38E-28
UVM	TSG	RPS15	GLTSCR2	0.898006971	1.54E-29

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS15	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS15	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS15	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPS15	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS15	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS15	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS15	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS15	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS15	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS15	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS15	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPS15	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS15	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS15	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS15	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS15	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPS15	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS15	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPS15	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPS15	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS15	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS15	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS15	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS15	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPS15	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPS15	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS15	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS15	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS15

EBNA-LP, SIRT7, CUL3, CUL1, COPS5, CAND1, RPS4X, RPL6, RPL7, RPLP1, RPS18, RPS7, RPSA, RPL3, RPS13, RPS2, RPS19, RPLP2, RPL9, RPL21, RPS16, RPS17, RPS23, RPS6, RPS15A, RPS3A, RPS26, RPS24, RPS14, RPS25, RPL36, RPS3, RPS28, RPS29, MRPL3, MRPL2, STT3B, ATP6V1D, ATP6V0A2, ATP6V0A1, MRPL24, PTRH2, ELAVL1, FUBP1, TCIRG1, MPV17, FLOT1, MRPL23, ICT1, SMURF1, FN1, CD81, IGSF8, ICAM1, MDM2, MDM4, RAPGEF1, PLA2G12A, SERINC3, UPF2, RPS10, RPS9, CEP76, TP53, TUBG1, TUBGCP3, G2E3, RNF2, LUZP4, HIST1H1A, HNRNPA1, PRR11, PAIP1, CASQ2, EPB41L3, MRPL14, RNPS1, RPL11, RPL15, RPL18A, RPL27, RPL27A, RPL28, RPL30, RPL31, RPL32, RPL35A, RPL36AL, RPL37, RPL37A, RPL5, RPS11, CADM1, FAU, NDUFS1, RPL10, RPL10L, RPL13, RPL14, RPL17, RPL18, RPL19, RPL22, RPL23, RPL23A, RPL24, RPL26, RPL26L1, RPL34, RPL39, RPL4, RPL7A, RPL8, RPLP0, RPS5, RPS27, RPS8, SEC61A1, AHSA1, HNRNPU, NPM1, CDK2AP1, Eif3a, Eif3e, Rpl35, Srp72, Rrbp1, EGFR, C1orf131, ZNF746, PTPRG, DUSP11, DUSP5, H2AFX, RRS1, FGF8, ZNF324B, GLTSCR2, SART3, HIST1H1E, ZC3HAV1, HIST1H1T, BHLHA15, MAK16, PDGFB, ZBTB48, ZNF169, NCL, CYLD, TRIM25, HDAC6, CFTR, HIF1AN, TRIM14, TMPO, HDAC4, AAR2, PIH1D1, EFTUD2, NFKB1, TNIP2, CHD3, CHD4, RIOK1, ESR2, HEXIM1, MEPCE, LARP7, AGR2, RECQL4, ZFP36L2, MYC, CDK9, Prkaa1, RC3H1, RC3H2, PHB, NR2C2, PPP1CC, MECOM, VRK1, COMMD3, SNRNP70, ITFG1, HMGB1, NFX1, WWP2, SQSTM1, LRRK2, PLEKHA4, PTEN, ZC3H18, RPS6KA2, SGOL1, ESR1, ERCC6, NAP1L1, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, LRRC59, INS, CDC42, BRD4, CIC, N, Apc2, FBP1, GSK3A, GSK3B, L3MBTL1, NPM3, DCAF13, CBX4, UFL1, DDRGK1, ATG3, UBQLN1, FZR1, LIN28B, ABT1, H2AFB3, PURG, SRSF5, SURF6, RPL13A, CCDC140, HIST1H1C, HIST1H2AE, FGF17, SRSF6, YBX2, HIST1H2AM, PNMAL1, GLI4, HIST1H1D, H2AFB2, LIN28A, LLPH, RSL1D1, ZBTB47, MYBBP1A, SRSF1, MAGEB2, HIST2H2AC, PRKRA, DDX21, REXO4, FGF13, SRSF3, RPL35, SRSF4, NEIL1, H1FNT, PRR3, PABPC5, KRR1, HIST1H1B, HIST1H4I, RBM4B, ZC3H3, MRPS27, RNF151, SRSF7, RPS4Y1, APOBEC3D, ZNF668, THAP3, ZNF574, HMGN4, RPSAP58, FGFBP1, ZNF346, CBX6, BTF3, FBXW7, RCHY1, PSMD9, CPEB1, KLF15, KLF16, KLF4, KLF5, KLF8, SP1, TLX1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPS15	chr19	1438865	C	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS15	chr19	1440068	G	C	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS15	chr19	1440374	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS15	LUAD	chr19	1440170	1440170	G	A	Missense_Mutation	p.R48Q	4
RPS15	UCEC	chr19	1440079	1440079	C	T	Missense_Mutation	p.R51W	2
RPS15	BRCA	chr19	1440145	1440145	C	T	Missense_Mutation	p.P73S	2
RPS15	STAD	chr19	1440417	1440417	G	A	Missense_Mutation		2
RPS15	LIHC	chr19	1440240	1440240	G	-	Frame_Shift_Del	p.Q71fs	2
RPS15	UCEC	chr19	1440203	1440203	G	T	Missense_Mutation	p.S92I	1
RPS15	BLCA	chr19	1440120	1440120	G	A	Silent	p.K64K	1
RPS15	LUAD	chr19	1440170	1440170	G	A	Missense_Mutation	p.R81Q	1
RPS15	SARC	chr19	1438503	1438503	G	T	Missense_Mutation	p.A27S	1
RPS15	COAD	chr19	1438865	1438865	C	T	Silent	p.D21D	1
RPS15	SKCM	chr19	1440453	1440453	C	T	Missense_Mutation	p.L144F	1
RPS15	DLBC	chr19	1440374	1440374	C	T	Silent	p.G117G	1
RPS15	SKCM	chr19	1440440	1440440	C	T	Silent	p.S139S	1
RPS15	HNSC	chr19	1440145	1440145	C	T	Missense_Mutation		1
RPS15	SKCM	chr19	1440453	1440453	C	T	Missense_Mutation	p.L111F	1
RPS15	HNSC	chr19	1440120	1440120	G	C	Missense_Mutation	p.K31N	1
RPS15	SKCM	chr19	1440440	1440440	C	T	Silent	p.S106S	1
RPS15	HNSC	chr19	1440120	1440120	G	C	Missense_Mutation	p.K64N	1
RPS15	STAD	chr19	1440417	1440417	G	A	Missense_Mutation	p.G99S	1
RPS15	BLCA	chr19	1440439	1440439	C	T	Missense_Mutation		1
RPS15	LIHC	chr19	1440288	1440288	G	-	Frame_Shift_Del	p.L120fs	1
RPS15	THYM	chr19	1440068	1440068	G	C	Missense_Mutation		1
RPS15	BLCA	chr19	1440120	1440120	G	A	Silent	p.K31K	1
RPS15	UCEC	chr19	1440407	1440407	T	C	Silent	p.H128H	1
RPS15	BLCA	chr19	1440439	1440439	C	T	Missense_Mutation	p.S106F	1
RPS15	LUAD	chr19	1440453	1440453	C	G	Missense_Mutation	p.L111V	1

Copy number variation (CNV) of RPS15
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS15
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
87373	N/A	EC584153	ACOT12	chr5	80637245	+	RPS15	chr19	1440486	-
87373	N/A	EC561218	RALYL	chr8	85095835	-	RPS15	chr19	1438808	+
77444	N/A	BF338609	RPS15	chr19	1440493	+	ATRX	chrX	76887503	-
98853	PRAD	TCGA-EJ-7125-01A	RPS15	chr19	1438891	+	DLGAP5	chr14	55617566	-
77444	N/A	BP366352	RPS15	chr19	1440492	+	PLK5	chr19	1534505	+
98459	N/A	EC565163	RPS15	chr19	1438891	+	SLC22A15	chr1	116594405	-
87377	N/A	EC578662	STEAP2	chr7	89864840	-	RPS15	chr19	1440431	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
READ	RPS15	0.247457926451315	-1.39651470556014	0.0089401690198278	0.00626520767028773	0.00884104342302468	103
LGG	RPS15	0.743427271448238	-0.296484337035011	0.027446939966843	0.0283430030069663	0.0283566852026048	525
KIRC	RPS15	1.23494404721728	0.211025663156656	0.0297442695600995	0.0322288925408205	0.029911290890123	604
KIRC	RPS15	1.23494404721728	0.211025663156656	0.0297442695600995	0.0322288925408205	0.029911290890123	604
UCEC	RPS15	0.581213686104719	-0.54263679955101	0.0298354348724279	0.0287359017793538	0.0314620872507298	188
KIRP	RPS15	1.52986073674483	0.425176709526206	0.0377677824820051	0.0433039130300063	0.0380007806670382	320
KIRP	RPS15	1.52986073674483	0.425176709526206	0.0377677824820051	0.0433039130300063	0.0380007806670382	320

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	RPS15	0.0205008225713287	0.57
ACC	RPS15	0.0299053963155853	0.81
KIRP	RPS15	0.0343426065700119	0.89

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPS15	0.00300927111884783	0.099
PAAD	RPS15	0.0252048282395102	0.78
SARC	RPS15	0.0168920349555729	0.54

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0023434	Chronic Lymphocytic Leukemia	2	ORPHANET
C0855095	Small Lymphocytic Lymphoma	2	ORPHANET
C1868683	B-CELL MALIGNANCY, LOW-GRADE	2	ORPHANET
C0024623	Malignant neoplasm of stomach	1	CTD_human
C1260899	Anemia, Diamond-Blackfan	1	GENOMICS_ENGLAND
C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human