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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS19 (NCBI Gene ID:6223)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS19
	Gene ID: 6223
	Gene Symbol	RPS19
	Gene ID	6223
	Gene Name	ribosomal protein S19
	Synonyms	DBA\|DBA1\|LOH19CR1\|S19\|eS19
	Cytomap	19q13.2
	Type of Gene	protein-coding
	Description	40S ribosomal protein S19loss of heterozygosity on chromosome 19, region 1loss of heterozygosity, 19, chromosomal region 1small ribosomal subunit protein eS19
	Modification date	20200313
	UniProtAcc	P39019

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS19	GO:0002548	monocyte chemotaxis	11226885
Hgene	RPS19	GO:0031640	killing of cells of other organism	15019208
Hgene	RPS19	GO:0050829	defense response to Gram-negative bacterium	15019208
Hgene	RPS19	GO:0060265	positive regulation of respiratory burst involved in inflammatory response	15750715
Hgene	RPS19	GO:0060266	negative regulation of respiratory burst involved in inflammatory response	15750715
Hgene	RPS19	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	15019208

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS19	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS19[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS19	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000593863	42373100	42373284	Frame-shift
ENST00000598742	42373100	42373284	Frame-shift
ENST00000593863	42373768	42373823	Frame-shift
ENST00000598742	42373768	42373823	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
THCA	RPS19	-2.32758478069179	0.00017855596420982
LUAD	RPS19	-1.60312048165889	0.00049387504195037
ESCA	RPS19	-1.36319696331652	0.0068359375
BLCA	RPS19	1.84549544688262	0.0360679626464844
KIRP	RPS19	-2.58536264561008	2.00234353542328e-08
KIRC	RPS19	-2.33153322465833	8.36006881044836e-12

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
GBM	RPS19	0.140342259	0.020666762
DLBC	RPS19	-0.013186814	0.045416725

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS19 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	Epifactor	RPS19	FBL	0.851286312	2.87E-23
BRCA	Epifactor	RPS19	FBL	0.80960777	1.23E-283
CESC	Cell metabolism gene	RPS19	SNRPD2	0.814319647	2.83E-74
CHOL	Cell metabolism gene	RPS19	SNRPD2	0.919520197	4.77E-19
CHOL	Epifactor	RPS19	FBL	0.881780723	1.26E-15
COAD	Cell metabolism gene	RPS19	SNRPD2	0.834939002	8.11E-87
COAD	TF	RPS19	ZNF581	0.802580548	2.37E-75
DLBC	Cell metabolism gene	RPS19	TIMM13	0.804493495	5.63E-12
DLBC	Cell metabolism gene	RPS19	TOMM22	0.806258023	4.67E-12
DLBC	Cell metabolism gene	RPS19	PSMB3	0.812943771	2.25E-12
DLBC	Cell metabolism gene	RPS19	TIMM9	0.821357488	8.59E-13
DLBC	Cell metabolism gene	RPS19	SNRPD2	0.829623293	3.18E-13
DLBC	Cell metabolism gene	RPS19	GFER	0.834762608	1.67E-13
DLBC	Cell metabolism gene	RPS19	GEMIN7	0.83553577	1.51E-13
DLBC	Cell metabolism gene	RPS19	NME2	0.842526665	6.02E-14
DLBC	Cell metabolism gene	RPS19	PFDN5	0.87109889	8.31E-16
DLBC	Cell metabolism gene	RPS19	FAU	0.919010815	3.22E-20
DLBC	CGC	RPS19	MAP2K2	0.831240509	2.60E-13
DLBC	Epifactor	RPS19	BRMS1	0.808979703	3.48E-12
DLBC	Epifactor	RPS19	FBL	0.817068417	1.41E-12
DLBC	Epifactor	RPS19	DMAP1	0.820383187	9.63E-13
DLBC	Epifactor	RPS19	TAF10	0.830125158	2.99E-13
DLBC	IUPHAR	RPS19	MAP2K2	0.831240509	2.60E-13
DLBC	Kinase	RPS19	MAP2K2	0.831240509	2.60E-13
DLBC	TF	RPS19	THAP3	0.830294814	2.92E-13
DLBC	TF	RPS19	NME2	0.842526665	6.02E-14
DLBC	TF	RPS19	ZNF581	0.845495327	4.02E-14
DLBC	TF	RPS19	THAP7	0.852782544	1.44E-14
DLBC	TSG	RPS19	TSSC4	0.802006484	7.32E-12
DLBC	TSG	RPS19	BRMS1	0.808979703	3.48E-12
DLBC	TSG	RPS19	GADD45GIP1	0.834628741	1.69E-13
DLBC	TSG	RPS19	GLTSCR2	0.861170045	4.09E-15
DLBC	TSG	RPS19	GNB2L1	0.885667182	6.20E-17
GBM	Cell metabolism gene	RPS19	SSR2	0.800793324	1.09E-39
GBM	Cell metabolism gene	RPS19	PFDN5	0.802971834	4.72E-40
GBM	Cell metabolism gene	RPS19	GEMIN7	0.842855378	1.29E-47
GBM	Cell metabolism gene	RPS19	SNRPD2	0.866528453	3.49E-53
GBM	TF	RPS19	ZNF90	0.838167318	1.27E-46
HNSC	Cell metabolism gene	RPS19	PFDN5	0.810206528	5.91E-133
HNSC	Cell metabolism gene	RPS19	POLR2I	0.814799242	1.20E-135
HNSC	Cell metabolism gene	RPS19	SNRPD2	0.86700401	9.40E-173
KICH	Cell metabolism gene	RPS19	FAU	0.808613985	3.26E-22
KICH	Cell metabolism gene	RPS19	SNRPD2	0.857132697	2.24E-27
KIRP	Cell metabolism gene	RPS19	FAU	0.848668577	8.48E-91
KIRP	Cell metabolism gene	RPS19	SNRPD2	0.86122058	2.28E-96
KIRP	Epifactor	RPS19	FBL	0.802239344	6.79E-74
LGG	Epifactor	RPS19	FBL	0.892217205	2.01E-184
LGG	TF	RPS19	ZNF581	0.848191893	7.85E-148
LIHC	Cell metabolism gene	RPS19	PFDN5	0.802320066	2.17E-96
LIHC	Cell metabolism gene	RPS19	SNRPD2	0.826720774	3.23E-107
LIHC	Epifactor	RPS19	FBL	0.855301745	2.73E-122
MESO	Cell metabolism gene	RPS19	SNRPD2	0.800531876	1.35E-20
PAAD	Cell metabolism gene	RPS19	FAU	0.822747376	2.82E-46
PCPG	Cell metabolism gene	RPS19	PGLS	0.809764014	1.05E-44
PCPG	Cell metabolism gene	RPS19	PFDN5	0.81942752	1.37E-46
PCPG	Epifactor	RPS19	FBL	0.830630478	6.38E-49
PCPG	TSG	RPS19	GNB2L1	0.827550175	2.90E-48
PCPG	TSG	RPS19	GLTSCR2	0.830249352	7.71E-49
PRAD	Cell metabolism gene	RPS19	TIMM13	0.80172289	1.38E-124
PRAD	Cell metabolism gene	RPS19	ZNRD1	0.814117929	1.85E-131
PRAD	Cell metabolism gene	RPS19	POLR2F	0.817531289	1.92E-133
PRAD	Cell metabolism gene	RPS19	PSMB7	0.819246567	1.86E-134
PRAD	Cell metabolism gene	RPS19	TIMM9	0.826308701	9.67E-139
PRAD	Cell metabolism gene	RPS19	TOMM7	0.829017821	1.95E-140
PRAD	Cell metabolism gene	RPS19	NME2	0.837014002	1.27E-145
PRAD	Cell metabolism gene	RPS19	POLR2I	0.839718671	1.94E-147
PRAD	Cell metabolism gene	RPS19	FAU	0.871265792	1.63E-171
PRAD	Cell metabolism gene	RPS19	SNRPD2	0.890129537	3.49E-189
PRAD	CGC	RPS19	NACA	0.815155936	4.65E-132
PRAD	Epifactor	RPS19	FBL	0.914202697	4.05E-217
PRAD	TF	RPS19	ZNF581	0.824072792	2.31E-137
PRAD	TF	RPS19	ZNF524	0.830674583	1.73E-141
PRAD	TF	RPS19	NME2	0.837014002	1.27E-145
PRAD	TSG	RPS19	GAS5	0.803688372	1.21E-125
PRAD	TSG	RPS19	GNB2L1	0.847087132	1.44E-152
READ	Cell metabolism gene	RPS19	SNRPD2	0.81407718	4.71E-26
TGCT	Cell metabolism gene	RPS19	POLR2I	0.860718523	5.21E-47
TGCT	Cell metabolism gene	RPS19	SNRPD2	0.874662723	2.70E-50
TGCT	Epifactor	RPS19	FBL	0.848800509	1.79E-44
THCA	Cell metabolism gene	RPS19	PGLS	0.803596563	1.46E-130
THCA	Cell metabolism gene	RPS19	FAU	0.858863277	9.39E-168
THCA	Cell metabolism gene	RPS19	SNRPD2	0.868139611	1.48E-175
THCA	Epifactor	RPS19	TAF10	0.801438319	2.35E-129
THCA	TSG	RPS19	GADD45GIP1	0.800589355	6.94E-129
THCA	TSG	RPS19	GNB2L1	0.828462512	1.24E-145
THYM	Cell metabolism gene	RPS19	PGP	0.801328378	1.51E-28
THYM	Cell metabolism gene	RPS19	MPST	0.80169381	1.37E-28
THYM	Cell metabolism gene	RPS19	TSTA3	0.802123604	1.22E-28
THYM	Cell metabolism gene	RPS19	IMPDH2	0.802988795	9.63E-29
THYM	Cell metabolism gene	RPS19	TOMM7	0.803432733	8.54E-29
THYM	Cell metabolism gene	RPS19	PAFAH1B3	0.804373542	6.60E-29
THYM	Cell metabolism gene	RPS19	HMOX2	0.805555302	4.76E-29
THYM	Cell metabolism gene	RPS19	NME2	0.807423441	2.83E-29
THYM	Cell metabolism gene	RPS19	DOHH	0.809083914	1.78E-29
THYM	Cell metabolism gene	RPS19	GSTP1	0.810611086	1.15E-29
THYM	Cell metabolism gene	RPS19	SSR4	0.812019096	7.70E-30
THYM	Cell metabolism gene	RPS19	PSMB10	0.81232088	7.06E-30
THYM	Cell metabolism gene	RPS19	GFER	0.81260854	6.50E-30
THYM	Cell metabolism gene	RPS19	LCMT1	0.814251486	4.04E-30
THYM	Cell metabolism gene	RPS19	PSME1	0.814746655	3.50E-30
THYM	Cell metabolism gene	RPS19	LSM4	0.815023445	3.22E-30
THYM	Cell metabolism gene	RPS19	POLD4	0.815067513	3.18E-30
THYM	Cell metabolism gene	RPS19	DGUOK	0.815093954	3.16E-30
THYM	Cell metabolism gene	RPS19	ATP5G1	0.817866265	1.39E-30
THYM	Cell metabolism gene	RPS19	POLE4	0.818236795	1.25E-30
THYM	Cell metabolism gene	RPS19	SEC61G	0.81937166	8.89E-31
THYM	Cell metabolism gene	RPS19	SNRPE	0.819949164	7.47E-31
THYM	Cell metabolism gene	RPS19	PHKG2	0.821939298	4.08E-31
THYM	Cell metabolism gene	RPS19	GEMIN6	0.82319315	2.78E-31
THYM	Cell metabolism gene	RPS19	PSMC5	0.825257259	1.47E-31
THYM	Cell metabolism gene	RPS19	TIMM17B	0.826474133	1.00E-31
THYM	Cell metabolism gene	RPS19	SMPD2	0.826497582	9.96E-32
THYM	Cell metabolism gene	RPS19	PSMD13	0.826770334	9.14E-32
THYM	Cell metabolism gene	RPS19	MVD	0.829333546	4.05E-32
THYM	Cell metabolism gene	RPS19	PSMB1	0.829744229	3.55E-32
THYM	Cell metabolism gene	RPS19	OAZ1	0.830210642	3.06E-32
THYM	Cell metabolism gene	RPS19	PSMC1	0.830310327	2.96E-32
THYM	Cell metabolism gene	RPS19	PTGES2	0.832960149	1.25E-32
THYM	Cell metabolism gene	RPS19	HSD17B10	0.83318694	1.16E-32
THYM	Cell metabolism gene	RPS19	LSM2	0.833585475	1.02E-32
THYM	Cell metabolism gene	RPS19	SNRPD3	0.833760036	9.63E-33
THYM	Cell metabolism gene	RPS19	IDH3G	0.835487202	5.43E-33
THYM	Cell metabolism gene	RPS19	POLD2	0.83636716	4.05E-33
THYM	Cell metabolism gene	RPS19	PHPT1	0.840040243	1.16E-33
THYM	Cell metabolism gene	RPS19	TBCB	0.84326174	3.80E-34
THYM	Cell metabolism gene	RPS19	TOMM22	0.843627701	3.34E-34
THYM	Cell metabolism gene	RPS19	PSME2	0.843633379	3.33E-34
THYM	Cell metabolism gene	RPS19	ALG3	0.843934697	3.00E-34
THYM	Cell metabolism gene	RPS19	TOMM40	0.845675194	1.62E-34
THYM	Cell metabolism gene	RPS19	WBSCR22	0.846223526	1.33E-34
THYM	Cell metabolism gene	RPS19	MIF	0.847290983	9.04E-35
THYM	Cell metabolism gene	RPS19	PMPCA	0.847651947	7.93E-35
THYM	Cell metabolism gene	RPS19	HMBS	0.849756725	3.68E-35
THYM	Cell metabolism gene	RPS19	NANS	0.849859627	3.54E-35
THYM	Cell metabolism gene	RPS19	PSMD4	0.850119149	3.22E-35
THYM	Cell metabolism gene	RPS19	SRM	0.850770764	2.53E-35
THYM	Cell metabolism gene	RPS19	PSMC3	0.853203432	1.02E-35
THYM	Cell metabolism gene	RPS19	TIMM10	0.853786556	8.16E-36
THYM	Cell metabolism gene	RPS19	EBP	0.859239858	9.89E-37
THYM	Cell metabolism gene	RPS19	MTX1	0.86137324	4.23E-37
THYM	Cell metabolism gene	RPS19	GEMIN7	0.862494533	2.69E-37
THYM	Cell metabolism gene	RPS19	POLR2J	0.862614781	2.56E-37
THYM	Cell metabolism gene	RPS19	GUK1	0.864639105	1.12E-37
THYM	Cell metabolism gene	RPS19	GMPPA	0.867376613	3.57E-38
THYM	Cell metabolism gene	RPS19	DPM3	0.880665974	9.55E-41
THYM	Cell metabolism gene	RPS19	ACOT8	0.88162271	6.07E-41
THYM	Cell metabolism gene	RPS19	ITPA	0.885293044	1.03E-41
THYM	Cell metabolism gene	RPS19	SSR2	0.885524532	9.16E-42
THYM	Cell metabolism gene	RPS19	POLR2F	0.885966478	7.36E-42
THYM	Cell metabolism gene	RPS19	APRT	0.887014203	4.37E-42
THYM	Cell metabolism gene	RPS19	PSMB7	0.888053137	2.59E-42
THYM	Cell metabolism gene	RPS19	EXOSC4	0.888265196	2.33E-42
THYM	Cell metabolism gene	RPS19	DPM2	0.889064341	1.55E-42
THYM	Cell metabolism gene	RPS19	EXOSC5	0.89485173	7.44E-44
THYM	Cell metabolism gene	RPS19	PSMB3	0.896372541	3.25E-44
THYM	Cell metabolism gene	RPS19	POLR2H	0.90127903	2.06E-45
THYM	Cell metabolism gene	RPS19	TIMM8B	0.903307768	6.29E-46
THYM	Cell metabolism gene	RPS19	SLC27A5	0.905117566	2.14E-46
THYM	Cell metabolism gene	RPS19	PFDN5	0.905990565	1.26E-46
THYM	Cell metabolism gene	RPS19	TIMM50	0.912597661	1.95E-48
THYM	Cell metabolism gene	RPS19	POLR2I	0.913497339	1.08E-48
THYM	Cell metabolism gene	RPS19	TIMM13	0.920501007	8.38E-51
THYM	Cell metabolism gene	RPS19	PGLS	0.924484741	4.32E-52
THYM	Cell metabolism gene	RPS19	FAU	0.929276575	9.78E-54
THYM	Cell metabolism gene	RPS19	SNRPD2	0.931358106	1.73E-54
THYM	CGC	RPS19	MAP2K2	0.813042627	5.74E-30
THYM	CGC	RPS19	ASPSCR1	0.828591483	5.13E-32
THYM	CGC	RPS19	MGMT	0.831040203	2.34E-32
THYM	CGC	RPS19	SDHAF2	0.837401726	2.86E-33
THYM	CGC	RPS19	RBM10	0.845448742	1.75E-34
THYM	CGC	RPS19	TFPT	0.872839657	3.39E-39
THYM	Epifactor	RPS19	CDK5	0.804696879	6.04E-29
THYM	Epifactor	RPS19	ZGPAT	0.809265647	1.69E-29
THYM	Epifactor	RPS19	PAF1	0.813923632	4.44E-30
THYM	Epifactor	RPS19	PPP4C	0.825875089	1.21E-31
THYM	Epifactor	RPS19	RRP8	0.829377929	3.99E-32
THYM	Epifactor	RPS19	CCDC101	0.842790522	4.48E-34
THYM	Epifactor	RPS19	RUVBL2	0.843715251	3.24E-34
THYM	Epifactor	RPS19	MBD3	0.845939083	1.47E-34
THYM	Epifactor	RPS19	INO80E	0.849424513	4.15E-35
THYM	Epifactor	RPS19	NOC2L	0.850256424	3.06E-35
THYM	Epifactor	RPS19	PRMT1	0.852811623	1.18E-35
THYM	Epifactor	RPS19	LAS1L	0.859092774	1.05E-36
THYM	Epifactor	RPS19	TFPT	0.872839657	3.39E-39
THYM	Epifactor	RPS19	C17orf49	0.875209023	1.18E-39
THYM	Epifactor	RPS19	EXOSC4	0.888265196	2.33E-42
THYM	Epifactor	RPS19	EXOSC5	0.89485173	7.44E-44
THYM	Epifactor	RPS19	PRPF31	0.898453331	1.03E-44
THYM	Epifactor	RPS19	ZNHIT1	0.898792675	8.48E-45
THYM	Epifactor	RPS19	TAF10	0.905007039	2.29E-46
THYM	Epifactor	RPS19	BRMS1	0.908607151	2.51E-47
THYM	Epifactor	RPS19	SIRT6	0.922901538	1.43E-51
THYM	Epifactor	RPS19	FBL	0.9344261	1.22E-55
THYM	IUPHAR	RPS19	FKBP1A	0.800795693	1.74E-28
THYM	IUPHAR	RPS19	MPST	0.80169381	1.37E-28
THYM	IUPHAR	RPS19	IMPDH2	0.802988795	9.63E-29
THYM	IUPHAR	RPS19	CDK5	0.804696879	6.04E-29
THYM	IUPHAR	RPS19	HMOX2	0.805555302	4.76E-29
THYM	IUPHAR	RPS19	ATP6V0B	0.808591669	2.04E-29
THYM	IUPHAR	RPS19	MMP24	0.810057189	1.35E-29
THYM	IUPHAR	RPS19	MAP2K2	0.813042627	5.74E-30
THYM	IUPHAR	RPS19	PPIA	0.813884609	4.49E-30
THYM	IUPHAR	RPS19	SIRT3	0.818748718	1.07E-30
THYM	IUPHAR	RPS19	PHKG2	0.821939298	4.08E-31
THYM	IUPHAR	RPS19	SMPD2	0.826497582	9.96E-32
THYM	IUPHAR	RPS19	MVD	0.829333546	4.05E-32
THYM	IUPHAR	RPS19	PSMB1	0.829744229	3.55E-32
THYM	IUPHAR	RPS19	PTGES2	0.832960149	1.25E-32
THYM	IUPHAR	RPS19	EGLN2	0.837333931	2.93E-33
THYM	IUPHAR	RPS19	PRMT1	0.852811623	1.18E-35
THYM	IUPHAR	RPS19	SLC27A5	0.905117566	2.14E-46
THYM	IUPHAR	RPS19	SIRT6	0.922901538	1.43E-51
THYM	Kinase	RPS19	CDK5	0.804696879	6.04E-29
THYM	Kinase	RPS19	MAP2K2	0.813042627	5.74E-30
THYM	Kinase	RPS19	PHKG2	0.821939298	4.08E-31
THYM	TF	RPS19	NME2	0.807423441	2.83E-29
THYM	TF	RPS19	ZGPAT	0.809265647	1.69E-29
THYM	TF	RPS19	ZNF511	0.817384583	1.61E-30
THYM	TF	RPS19	GLI4	0.820523655	6.28E-31
THYM	TF	RPS19	DRAP1	0.821126476	5.23E-31
THYM	TF	RPS19	REXO4	0.823560742	2.48E-31
THYM	TF	RPS19	USF1	0.825691793	1.28E-31
THYM	TF	RPS19	ZBTB48	0.825757422	1.26E-31
THYM	TF	RPS19	IRF3	0.834626398	7.23E-33
THYM	TF	RPS19	THAP3	0.837167052	3.09E-33
THYM	TF	RPS19	ZNF32	0.837346501	2.91E-33
THYM	TF	RPS19	MBD3	0.845939083	1.47E-34
THYM	TF	RPS19	ZNF688	0.845958092	1.46E-34
THYM	TF	RPS19	ETV2	0.851669942	1.81E-35
THYM	TF	RPS19	ZNF428	0.858161592	1.51E-36
THYM	TF	RPS19	THAP7	0.861205178	4.52E-37
THYM	TF	RPS19	ZNF524	0.879682633	1.52E-40
THYM	TF	RPS19	ZNF787	0.897137225	2.13E-44
THYM	TF	RPS19	ZNF581	0.903122361	7.02E-46
THYM	TSG	RPS19	PYCARD	0.803394028	8.63E-29
THYM	TSG	RPS19	GSTP1	0.810611086	1.15E-29
THYM	TSG	RPS19	ST20	0.812890886	5.99E-30
THYM	TSG	RPS19	SIRT3	0.818748718	1.07E-30
THYM	TSG	RPS19	STUB1	0.821034352	5.38E-31
THYM	TSG	RPS19	ZBTB48	0.825757422	1.26E-31
THYM	TSG	RPS19	IRF3	0.834626398	7.23E-33
THYM	TSG	RPS19	PARK7	0.841336367	7.44E-34
THYM	TSG	RPS19	GABARAP	0.85396383	7.63E-36
THYM	TSG	RPS19	NPRL2	0.868091234	2.64E-38
THYM	TSG	RPS19	GLTSCR2	0.871477445	6.16E-39
THYM	TSG	RPS19	GNB2L1	0.885877779	7.69E-42
THYM	TSG	RPS19	TSSC4	0.890174353	8.78E-43
THYM	TSG	RPS19	BRMS1	0.908607151	2.51E-47
THYM	TSG	RPS19	GADD45GIP1	0.919340515	1.93E-50
THYM	TSG	RPS19	SIRT6	0.922901538	1.43E-51
UCEC	Cell metabolism gene	RPS19	POLR2I	0.804963754	5.37E-47
UCEC	Cell metabolism gene	RPS19	SNRPD2	0.827037174	1.13E-51
UCS	Cell metabolism gene	RPS19	PGP	0.801328378	1.51E-28
UCS	Cell metabolism gene	RPS19	MPST	0.80169381	1.37E-28
UCS	Cell metabolism gene	RPS19	TSTA3	0.802123604	1.22E-28
UCS	Cell metabolism gene	RPS19	IMPDH2	0.802988795	9.63E-29
UCS	Cell metabolism gene	RPS19	TOMM7	0.803432733	8.54E-29
UCS	Cell metabolism gene	RPS19	PAFAH1B3	0.804373542	6.60E-29
UCS	Cell metabolism gene	RPS19	HMOX2	0.805555302	4.76E-29
UCS	Cell metabolism gene	RPS19	NME2	0.807423441	2.83E-29
UCS	Cell metabolism gene	RPS19	DOHH	0.809083914	1.78E-29
UCS	Cell metabolism gene	RPS19	GSTP1	0.810611086	1.15E-29
UCS	Cell metabolism gene	RPS19	SSR4	0.812019096	7.70E-30
UCS	Cell metabolism gene	RPS19	PSMB10	0.81232088	7.06E-30
UCS	Cell metabolism gene	RPS19	GFER	0.81260854	6.50E-30
UCS	Cell metabolism gene	RPS19	LCMT1	0.814251486	4.04E-30
UCS	Cell metabolism gene	RPS19	PSME1	0.814746655	3.50E-30
UCS	Cell metabolism gene	RPS19	LSM4	0.815023445	3.22E-30
UCS	Cell metabolism gene	RPS19	POLD4	0.815067513	3.18E-30
UCS	Cell metabolism gene	RPS19	DGUOK	0.815093954	3.16E-30
UCS	Cell metabolism gene	RPS19	ATP5G1	0.817866265	1.39E-30
UCS	Cell metabolism gene	RPS19	POLE4	0.818236795	1.25E-30
UCS	Cell metabolism gene	RPS19	SEC61G	0.81937166	8.89E-31
UCS	Cell metabolism gene	RPS19	SNRPE	0.819949164	7.47E-31
UCS	Cell metabolism gene	RPS19	PHKG2	0.821939298	4.08E-31
UCS	Cell metabolism gene	RPS19	GEMIN6	0.82319315	2.78E-31
UCS	Cell metabolism gene	RPS19	PSMC5	0.825257259	1.47E-31
UCS	Cell metabolism gene	RPS19	TIMM17B	0.826474133	1.00E-31
UCS	Cell metabolism gene	RPS19	SMPD2	0.826497582	9.96E-32
UCS	Cell metabolism gene	RPS19	PSMD13	0.826770334	9.14E-32
UCS	Cell metabolism gene	RPS19	MVD	0.829333546	4.05E-32
UCS	Cell metabolism gene	RPS19	PSMB1	0.829744229	3.55E-32
UCS	Cell metabolism gene	RPS19	OAZ1	0.830210642	3.06E-32
UCS	Cell metabolism gene	RPS19	PSMC1	0.830310327	2.96E-32
UCS	Cell metabolism gene	RPS19	PTGES2	0.832960149	1.25E-32
UCS	Cell metabolism gene	RPS19	HSD17B10	0.83318694	1.16E-32
UCS	Cell metabolism gene	RPS19	LSM2	0.833585475	1.02E-32
UCS	Cell metabolism gene	RPS19	SNRPD3	0.833760036	9.63E-33
UCS	Cell metabolism gene	RPS19	IDH3G	0.835487202	5.43E-33
UCS	Cell metabolism gene	RPS19	POLD2	0.83636716	4.05E-33
UCS	Cell metabolism gene	RPS19	PHPT1	0.840040243	1.16E-33
UCS	Cell metabolism gene	RPS19	TBCB	0.84326174	3.80E-34
UCS	Cell metabolism gene	RPS19	TOMM22	0.843627701	3.34E-34
UCS	Cell metabolism gene	RPS19	PSME2	0.843633379	3.33E-34
UCS	Cell metabolism gene	RPS19	ALG3	0.843934697	3.00E-34
UCS	Cell metabolism gene	RPS19	TOMM40	0.845675194	1.62E-34
UCS	Cell metabolism gene	RPS19	WBSCR22	0.846223526	1.33E-34
UCS	Cell metabolism gene	RPS19	MIF	0.847290983	9.04E-35
UCS	Cell metabolism gene	RPS19	PMPCA	0.847651947	7.93E-35
UCS	Cell metabolism gene	RPS19	HMBS	0.849756725	3.68E-35
UCS	Cell metabolism gene	RPS19	NANS	0.849859627	3.54E-35
UCS	Cell metabolism gene	RPS19	PSMD4	0.850119149	3.22E-35
UCS	Cell metabolism gene	RPS19	SRM	0.850770764	2.53E-35
UCS	Cell metabolism gene	RPS19	PSMC3	0.853203432	1.02E-35
UCS	Cell metabolism gene	RPS19	TIMM10	0.853786556	8.16E-36
UCS	Cell metabolism gene	RPS19	EBP	0.859239858	9.89E-37
UCS	Cell metabolism gene	RPS19	MTX1	0.86137324	4.23E-37
UCS	Cell metabolism gene	RPS19	GEMIN7	0.862494533	2.69E-37
UCS	Cell metabolism gene	RPS19	POLR2J	0.862614781	2.56E-37
UCS	Cell metabolism gene	RPS19	GUK1	0.864639105	1.12E-37
UCS	Cell metabolism gene	RPS19	GMPPA	0.867376613	3.57E-38
UCS	Cell metabolism gene	RPS19	DPM3	0.880665974	9.55E-41
UCS	Cell metabolism gene	RPS19	ACOT8	0.88162271	6.07E-41
UCS	Cell metabolism gene	RPS19	ITPA	0.885293044	1.03E-41
UCS	Cell metabolism gene	RPS19	SSR2	0.885524532	9.16E-42
UCS	Cell metabolism gene	RPS19	POLR2F	0.885966478	7.36E-42
UCS	Cell metabolism gene	RPS19	APRT	0.887014203	4.37E-42
UCS	Cell metabolism gene	RPS19	PSMB7	0.888053137	2.59E-42
UCS	Cell metabolism gene	RPS19	EXOSC4	0.888265196	2.33E-42
UCS	Cell metabolism gene	RPS19	DPM2	0.889064341	1.55E-42
UCS	Cell metabolism gene	RPS19	EXOSC5	0.89485173	7.44E-44
UCS	Cell metabolism gene	RPS19	PSMB3	0.896372541	3.25E-44
UCS	Cell metabolism gene	RPS19	POLR2H	0.90127903	2.06E-45
UCS	Cell metabolism gene	RPS19	TIMM8B	0.903307768	6.29E-46
UCS	Cell metabolism gene	RPS19	SLC27A5	0.905117566	2.14E-46
UCS	Cell metabolism gene	RPS19	PFDN5	0.905990565	1.26E-46
UCS	Cell metabolism gene	RPS19	TIMM50	0.912597661	1.95E-48
UCS	Cell metabolism gene	RPS19	POLR2I	0.913497339	1.08E-48
UCS	Cell metabolism gene	RPS19	TIMM13	0.920501007	8.38E-51
UCS	Cell metabolism gene	RPS19	PGLS	0.924484741	4.32E-52
UCS	Cell metabolism gene	RPS19	FAU	0.929276575	9.78E-54
UCS	Cell metabolism gene	RPS19	SNRPD2	0.931358106	1.73E-54
UCS	CGC	RPS19	MAP2K2	0.813042627	5.74E-30
UCS	CGC	RPS19	ASPSCR1	0.828591483	5.13E-32
UCS	CGC	RPS19	MGMT	0.831040203	2.34E-32
UCS	CGC	RPS19	SDHAF2	0.837401726	2.86E-33
UCS	CGC	RPS19	RBM10	0.845448742	1.75E-34
UCS	CGC	RPS19	TFPT	0.872839657	3.39E-39
UCS	Epifactor	RPS19	CDK5	0.804696879	6.04E-29
UCS	Epifactor	RPS19	ZGPAT	0.809265647	1.69E-29
UCS	Epifactor	RPS19	PAF1	0.813923632	4.44E-30
UCS	Epifactor	RPS19	PPP4C	0.825875089	1.21E-31
UCS	Epifactor	RPS19	RRP8	0.829377929	3.99E-32
UCS	Epifactor	RPS19	CCDC101	0.842790522	4.48E-34
UCS	Epifactor	RPS19	RUVBL2	0.843715251	3.24E-34
UCS	Epifactor	RPS19	MBD3	0.845939083	1.47E-34
UCS	Epifactor	RPS19	INO80E	0.849424513	4.15E-35
UCS	Epifactor	RPS19	NOC2L	0.850256424	3.06E-35
UCS	Epifactor	RPS19	PRMT1	0.852811623	1.18E-35
UCS	Epifactor	RPS19	LAS1L	0.859092774	1.05E-36
UCS	Epifactor	RPS19	TFPT	0.872839657	3.39E-39
UCS	Epifactor	RPS19	C17orf49	0.875209023	1.18E-39
UCS	Epifactor	RPS19	EXOSC4	0.888265196	2.33E-42
UCS	Epifactor	RPS19	EXOSC5	0.89485173	7.44E-44
UCS	Epifactor	RPS19	PRPF31	0.898453331	1.03E-44
UCS	Epifactor	RPS19	ZNHIT1	0.898792675	8.48E-45
UCS	Epifactor	RPS19	TAF10	0.905007039	2.29E-46
UCS	Epifactor	RPS19	BRMS1	0.908607151	2.51E-47
UCS	Epifactor	RPS19	SIRT6	0.922901538	1.43E-51
UCS	Epifactor	RPS19	FBL	0.9344261	1.22E-55
UCS	IUPHAR	RPS19	FKBP1A	0.800795693	1.74E-28
UCS	IUPHAR	RPS19	MPST	0.80169381	1.37E-28
UCS	IUPHAR	RPS19	IMPDH2	0.802988795	9.63E-29
UCS	IUPHAR	RPS19	CDK5	0.804696879	6.04E-29
UCS	IUPHAR	RPS19	HMOX2	0.805555302	4.76E-29
UCS	IUPHAR	RPS19	ATP6V0B	0.808591669	2.04E-29
UCS	IUPHAR	RPS19	MMP24	0.810057189	1.35E-29
UCS	IUPHAR	RPS19	MAP2K2	0.813042627	5.74E-30
UCS	IUPHAR	RPS19	PPIA	0.813884609	4.49E-30
UCS	IUPHAR	RPS19	SIRT3	0.818748718	1.07E-30
UCS	IUPHAR	RPS19	PHKG2	0.821939298	4.08E-31
UCS	IUPHAR	RPS19	SMPD2	0.826497582	9.96E-32
UCS	IUPHAR	RPS19	MVD	0.829333546	4.05E-32
UCS	IUPHAR	RPS19	PSMB1	0.829744229	3.55E-32
UCS	IUPHAR	RPS19	PTGES2	0.832960149	1.25E-32
UCS	IUPHAR	RPS19	EGLN2	0.837333931	2.93E-33
UCS	IUPHAR	RPS19	PRMT1	0.852811623	1.18E-35
UCS	IUPHAR	RPS19	SLC27A5	0.905117566	2.14E-46
UCS	IUPHAR	RPS19	SIRT6	0.922901538	1.43E-51
UCS	Kinase	RPS19	CDK5	0.804696879	6.04E-29
UCS	Kinase	RPS19	MAP2K2	0.813042627	5.74E-30
UCS	Kinase	RPS19	PHKG2	0.821939298	4.08E-31
UCS	TF	RPS19	NME2	0.807423441	2.83E-29
UCS	TF	RPS19	ZGPAT	0.809265647	1.69E-29
UCS	TF	RPS19	ZNF511	0.817384583	1.61E-30
UCS	TF	RPS19	GLI4	0.820523655	6.28E-31
UCS	TF	RPS19	DRAP1	0.821126476	5.23E-31
UCS	TF	RPS19	REXO4	0.823560742	2.48E-31
UCS	TF	RPS19	USF1	0.825691793	1.28E-31
UCS	TF	RPS19	ZBTB48	0.825757422	1.26E-31
UCS	TF	RPS19	IRF3	0.834626398	7.23E-33
UCS	TF	RPS19	THAP3	0.837167052	3.09E-33
UCS	TF	RPS19	ZNF32	0.837346501	2.91E-33
UCS	TF	RPS19	MBD3	0.845939083	1.47E-34
UCS	TF	RPS19	ZNF688	0.845958092	1.46E-34
UCS	TF	RPS19	ETV2	0.851669942	1.81E-35
UCS	TF	RPS19	ZNF428	0.858161592	1.51E-36
UCS	TF	RPS19	THAP7	0.861205178	4.52E-37
UCS	TF	RPS19	ZNF524	0.879682633	1.52E-40
UCS	TF	RPS19	ZNF787	0.897137225	2.13E-44
UCS	TF	RPS19	ZNF581	0.903122361	7.02E-46
UCS	TSG	RPS19	PYCARD	0.803394028	8.63E-29
UCS	TSG	RPS19	GSTP1	0.810611086	1.15E-29
UCS	TSG	RPS19	ST20	0.812890886	5.99E-30
UCS	TSG	RPS19	SIRT3	0.818748718	1.07E-30
UCS	TSG	RPS19	STUB1	0.821034352	5.38E-31
UCS	TSG	RPS19	ZBTB48	0.825757422	1.26E-31
UCS	TSG	RPS19	IRF3	0.834626398	7.23E-33
UCS	TSG	RPS19	PARK7	0.841336367	7.44E-34
UCS	TSG	RPS19	GABARAP	0.85396383	7.63E-36
UCS	TSG	RPS19	NPRL2	0.868091234	2.64E-38
UCS	TSG	RPS19	GLTSCR2	0.871477445	6.16E-39
UCS	TSG	RPS19	GNB2L1	0.885877779	7.69E-42
UCS	TSG	RPS19	TSSC4	0.890174353	8.78E-43
UCS	TSG	RPS19	BRMS1	0.908607151	2.51E-47
UCS	TSG	RPS19	GADD45GIP1	0.919340515	1.93E-50
UCS	TSG	RPS19	SIRT6	0.922901538	1.43E-51
UVM	Cell metabolism gene	RPS19	MPST	0.804431672	2.54E-19
UVM	Cell metabolism gene	RPS19	SAT2	0.810310973	8.69E-20
UVM	Cell metabolism gene	RPS19	SSR2	0.826728188	3.55E-21
UVM	Cell metabolism gene	RPS19	FAU	0.88146764	3.92E-27
UVM	CGC	RPS19	TRAF7	0.802634978	3.49E-19
UVM	Epifactor	RPS19	FBL	0.930185134	1.09E-35
UVM	IUPHAR	RPS19	MPST	0.804431672	2.54E-19
UVM	TF	RPS19	ZNF581	0.862208345	9.50E-25
UVM	TSG	RPS19	GNB2L1	0.854405294	6.97E-24
UVM	TSG	RPS19	GLTSCR2	0.914118434	2.58E-32

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS19	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS19	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS19	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPS19	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS19	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS19	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS19	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS19	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS19	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS19	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS19	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPS19	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS19	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS19	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS19	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS19	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPS19	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS19	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPS19	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPS19	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS19	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS19	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS19	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS19	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPS19	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPS19	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS19	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS19	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS19

MAGEB2, PINX1, CNBP, FGF2, SRRM2, SRRM1, POT1, POU5F1, CD4, RAD21, ARRB2, SIRT7, NFX1, CUL3, CUL5, CDK2, CUL1, COPS5, CAND1, INPPL1, CBL, GRB2, SHC1, CRK, RPS4X, APP, RPL12, RPL14, RPL18A, RPL18, RPL19, RPL21, RPL23A, RPL31, RPL5, RPL6, RPL7A, RPL7, RPS11, RPS13, RPS15A, RPS16, RPS23, RPS26, RPS28, RPS2, RPS3, RPS5, RPS6, RPS8, RPS12, RPS3A, RPS15, RPL11, RPL9, RPL23, RPL10A, RPS24, RPL24, RPL37A, RPL4, RPL15, RPLP1, RPSA, RPS25, RPS14, RPL22, RPS10, RPS9, RPS7, RPS20, RPL35, RPL38, RPL17, RPS27A, RPS21, EEF1A1, EEF2, NCL, SLC25A5, HNRNPA2B1, RPL10L, RPLP0P6, STT3B, MRRF, MRPL53, RRBP1, UBL4A, RBMS1, STX7, RFX5, ACAA1, PIN4, TBL2, SUGP1, NQO1, CPSF7, MRPS28, PLEK2, SMURF1, VCAM1, FN1, ITGA4, PAN2, CD81, IGSF8, ICAM1, RAD52, TXNDC11, TRAP1, PARK2, EIF3E, RPS17, RPS18, EIF2A, FAU, RPL28, RPS29, SERBP1, TSR1, WIBG, AURKA, CEP250, NEDD1, PPP2R1A, TUBGCP2, TUBGCP4, TP53, HUWE1, CCDC8, RNF2, RPS6KB2, ASCC2, KPNA1, PRPF4, RPL10, RPL13, RPL13A, RPL27, RPL27A, RPL30, RPL35A, RPL36, ATP1B1, ATP1B3, KLHDC4, RPL26, RPL3, RPL8, RPLP0, RPLP2, LOC101929876, RPS27, THRAP3, UBA52, SFN, BLM, KRAS, EWSR1, HNRNPU, NPM1, Eif3a, Eif3e, Rpl35, Srp72, Rrbp1, TRIM29, MCM2, Mdm2, RC3H1, EIF2S2, RRS1, HIST1H1E, PRPF31, RABGGTB, FNTA, CYLD, TRIM25, HEY1, BRCA1, MTF1, TRIM14, YAF2, HDAC4, JUP, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, CHD3, CHD4, RNF31, TNF, SPDL1, RIOK1, HEXIM1, MEPCE, LARP7, RNF123, PPT1, HERC2, RECQL4, REST, ZFP36L2, MYC, CDK9, KRT17, KIAA1429, EIF4B, RC3H2, ZBTB7A, PHB, PPP1CC, ATXN3, VRK1, HIST1H4A, SNRNP70, Dppa3, ITFG1, ARAF, HMGB1, BIRC3, WWP2, SOX2, LRRK2, CMTR1, SPG21, ARIH2, PLEKHA4, YAP1, TFCP2, FANCD2, HCVgp1, ZC3H18, VDAC2, HIST1H1B, ORF14, ORF8, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, LRRC59, BRD4, RBM45, CIC, Apc2, RBM39, FBP1, GSK3A, BKRF1, RIN3, RAD51, TOP1, NONO, NUFIP2, METTL17, DDX42, PSPC1, EIF5A, PPIL4, NSRP1, FAM76B, SART1, PPP1R10, LIN28A, NUDT21, CBX4, SFPQ, ATXN2L, YY1, NDC80, DCAF13, FIP1L1, CTTN, RPA3, TSPYL5, SP100, PRPF4B, CCNT1, C1orf35, PRPF40A, LRPAP1, MECP2, RBM25, TOX4, MFAP1, POP1, TAF2, LYAR, DDX56, WDR82, CSNK1D, RCL1, POU2F1, SPOP, UFL1, DDRGK1, TRIM37, ATG10, UBQLN1, FZR1, WDR5, NAA40, HIST1H1C, RBM19, KRI1, DDX18, MTERF3, ZNF646, ZNF184, UTP3, BAZ1B, ZFP90, SF3B1, DDX31, YBX1, ZNF485, DDX21, NSA2, SF3B2, U2SURP, ZBTB24, KRR1, RPL36AL, REXO4, RSBN1, SSB, LARP1, ZNF629, FGF13, GLE1, YBX3, UTP23, CMSS1, ZCRB1, GNL2, AATF, HP1BP3, ZNF22, HIST1H2AG, RBM5, GPATCH11, SCAF11, CEBPZ, GLYR1, NOP10, RRP12, FARP2, WHSC1, NIFK, TOE1, DDX10, CHERP, HIST1H1T, STAU2, ZNF16, H1FX, NGDN, ZFP91, ZBTB11, SMARCA5, DHX57, ZNF275, NTN1, AKAP17A, SRSF8, MPHOSPH10, ZNF574, ZC3H8, RPL26L1, ZNF512, IMP4, ZNF320, FARS2, CTCF, PRDM15, DKC1, ZC3HAV1, ZKSCAN8, ZFR, SMARCA1, ZNF711, DHX30, NOL10, ZNF768, ZNF70, ZNF346, LARP1B, RBM28, BOP1, NOM1, ZSCAN25, PURA, HIST1H1D, DDX27, ZNF354A, BMS1, ZNF668, RSL1D1, RRP15, DAXX, FTSJ3, HIST1H2AM, NOP16, HIST2H2AB, DDX24, SNRPA1, ZNF777, STAU1, DDX55, GZF1, SRSF4, SRSF5, SRSF6, PPAN-P2RY11, NOC3L, SRSF1, HIST1H1A, SF3B4, HNRNPR, NOC4L, GTPBP4, CBX6, NOL12, FBL, PAPD5, DIMT1, IMP3, SURF6, SMURF2, KNOP1, HIST2H2AC, EPB41L5, MOV10, SREK1, SDAD1, LUC7L, RPF1, GLTSCR2, TRUB2, CCDC59, DDX50, DHX36, FAM207A, YTHDF1, PRKRIR, PAK1IP1, DDX54, RPS4Y1, MRPL27, NOP14, NAT10, H2AFY, TTF1, ZCCHC3, MYBBP1A, YTHDC2, RRP1B, ABT1, NOP56, RPS26P11, RBM42, LTV1, GAR1, HIST1H2AE, PURB, RPS4Y2, RPSAP58, FAM111B, EPB41L4B, SRPK2, HJURP, CCDC137, OASL, BYSL, SPATS2L, RBM17, NKRF, BTF3, FBXW7, NLRP7, M, nsp1, nsp4, RCHY1, SQSTM1, PER2, CPEB1, KLF4, SP1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPS19	chr19	42364021	T	C	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_1
RPS19	chr19	42364072	A	C	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_1
RPS19	chr19	42364086	T	C	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_1
RPS19	chr19	42364126	G	A	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_1
RPS19	chr19	42364170	C	G	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_1
RPS19	chr19	42364193	C	T	single_nucleotide_variant	Uncertain_significance	not_provided
RPS19	chr19	42364209	G	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_1
RPS19	chr19	42364213	A	AAGCC	Insertion	Benign	Diamond-Blackfan_anemia\|not_provided
RPS19	chr19	42364221	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia
RPS19	chr19	42364286	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_1
RPS19	chr19	42364310	G	A	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_1
RPS19	chr19	42364334	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_1	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS19	chr19	42364350	A	G	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_1	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS19	chr19	42364373	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_1	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
RPS19	chr19	42364385	G	T	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
RPS19	chr19	42364395	T	C	single_nucleotide_variant	Benign	not_specified	SO:0002073\|no_sequence_alteration,SO:0001627\|intron_variant	SO:0002073\|no_sequence_alteration,SO:0001627\|intron_variant
RPS19	chr19	42364453	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
RPS19	chr19	42364831	A	G	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_1	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS19	chr19	42364832	C	T	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_1	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS19	chr19	42364836	C	A	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_1	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS19	chr19	42364838	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Diamond-Blackfan_anemia_1\|not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS19	chr19	42364847	G	A	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant
RPS19	chr19	42364847	G	T	single_nucleotide_variant	Pathogenic	not_provided	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant
RPS19	chr19	42364854	G	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS19	chr19	42364856	T	TA	Duplication	Pathogenic	Diamond-Blackfan_anemia	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS19	chr19	42364859	T	A	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS19	chr19	42364859	TG	T	Deletion	Pathogenic	Diamond-Blackfan_anemia	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS19	chr19	42364887	G	T	single_nucleotide_variant	Pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS19	chr19	42364893	G	C	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS19	chr19	42364897	T	C	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS19	chr19	42364901	A	AGCCT	Duplication	Pathogenic	Diamond-Blackfan_anemia	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS19	chr19	42364901	A	G	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS19	chr19	42364904	C	G	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_1\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS19	chr19	42364912	A	G	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_1\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS19	chr19	42364921	T	A	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_1	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS19	chr19	42364923	TG	T	Deletion	Uncertain_significance	Diamond-Blackfan_anemia	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS19	chr19	42365089	A	G	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS19	chr19	42365166	C	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS19	chr19	42365171	T	G	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS19	chr19	42365180	G	A	single_nucleotide_variant	Likely_pathogenic	Diamond-Blackfan_anemia	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
RPS19	chr19	42365180	G	C	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
RPS19	chr19	42365184	C	G	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS19	chr19	42365184	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS19	chr19	42365196	A	G	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS19	chr19	42365207	G	A	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_1	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS19	chr19	42365208	G	A	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS19	chr19	42365213	A	AT	Duplication	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS19	chr19	42365235	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS19	chr19	42365235	CAA	C	Deletion	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS19	chr19	42365237	AAG	A	Microsatellite	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS19	chr19	42365248	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS19	chr19	42365273	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_1\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS19	chr19	42365286	G	C	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_1	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPS19	chr19	42373092	T	C	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS19	chr19	42373099	A	G	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
RPS19	chr19	42373103	TC	CT	Indel	Uncertain_significance	Diamond-Blackfan_anemia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS19	chr19	42373106	A	C	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS19	chr19	42373111	G	A	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_1	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant
RPS19	chr19	42373112	C	T	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_1\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS19	chr19	42373113	G	A	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia\|not_provided	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant
RPS19	chr19	42373113	G	C	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant
RPS19	chr19	42373120	G	C	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant
RPS19	chr19	42373126	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_1	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant
RPS19	chr19	42373136	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS19	chr19	42373142	G	T	single_nucleotide_variant	Likely_pathogenic	Landsteiner-Wiener_phenotype	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS19	chr19	42373178	A	T	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_1	SO:0001583\|missense_variant,SO:0001587\|nonsense	SO:0001583\|missense_variant,SO:0001587\|nonsense
RPS19	chr19	42373183	C	CG	Duplication	Pathogenic	Diamond-Blackfan_anemia	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS19	chr19	42373187	G	A	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_1	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS19	chr19	42373208	C	T	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_1\|not_provided	SO:0001583\|missense_variant,SO:0001587\|nonsense	SO:0001583\|missense_variant,SO:0001587\|nonsense
RPS19	chr19	42373220	A	AGT	Microsatellite	Pathogenic	Diamond-Blackfan_anemia	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS19	chr19	42373223	GT	CAGCCGA	Indel	Pathogenic	Diamond-Blackfan_anemia_1	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS19	chr19	42373232	CG	C	Deletion	Pathogenic	Diamond-Blackfan_anemia_1	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS19	chr19	42373236	T	A	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia\|not_provided	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant
RPS19	chr19	42373245	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant
RPS19	chr19	42373261	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant
RPS19	chr19	42373262	ATGG	A	Microsatellite	Likely_pathogenic	not_provided	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
RPS19	chr19	42373287	A	C	single_nucleotide_variant	Likely_pathogenic	Diamond-Blackfan_anemia_1	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS19	chr19	42373298	G	A	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_1\|not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS19	chr19	42373302	G	C	single_nucleotide_variant	Benign/Likely_benign	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_1\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS19	chr19	42373764	C	G	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_1	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
RPS19	chr19	42373778	A	ACT	Duplication	Pathogenic	Diamond-Blackfan_anemia_1	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS19	chr19	42373783	C	CA	Duplication	Pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS19	chr19	42373784	A	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant
RPS19	chr19	42373792	G	A	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_1	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant
RPS19	chr19	42373794	C	T	single_nucleotide_variant	Likely_pathogenic	Diamond-Blackfan_anemia	SO:0001583\|missense_variant,SO:0001587\|nonsense	SO:0001583\|missense_variant,SO:0001587\|nonsense
RPS19	chr19	42373794	CAA	C	Deletion	Pathogenic	Diamond-Blackfan_anemia	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS19	chr19	42373805	G	A	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Diamond-Blackfan_anemia\|Diamond-Blackfan_anemia_1	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant
RPS19	chr19	42373817	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant
RPS19	chr19	42373818	G	T	single_nucleotide_variant	Pathogenic	not_provided	SO:0001583\|missense_variant,SO:0001587\|nonsense	SO:0001583\|missense_variant,SO:0001587\|nonsense
RPS19	chr19	42373822	A	G	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant
RPS19	chr19	42373825	T	C	single_nucleotide_variant	Pathogenic	not_provided	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RPS19	chr19	42373829	G	C	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS19	chr19	42373835	G	A	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_1\|not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS19	chr19	42375288	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS19	chr19	42375410	T	TTCCCACAG	Duplication	Uncertain_significance	not_provided	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
RPS19	chr19	42375499	T	C	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS19	ESCA	chr19	42373777	42373777	A	G	Missense_Mutation	p.K122R	3
RPS19	KIRC	chr19	42364899	42364899	G	T	Missense_Mutation	p.A19S	2
RPS19	CESC	chr19	42364896	42364896	C	G	Missense_Mutation	p.L18V	2
RPS19	UCEC	chr19	42373817	42373817	C	G	Silent	p.A135	2
RPS19	ESCA	chr19	42364858	42364858	C	A	Missense_Mutation	p.T5N	2
RPS19	ESCA	chr19	42373777	42373777	A	G	Missense_Mutation		2
RPS19	SKCM	chr19	42364908	42364908	C	T	Missense_Mutation	p.L22F	2
RPS19	BLCA	chr19	42373788	42373788	C	T	Nonsense_Mutation	p.Q126*	2
RPS19	CESC	chr19	42364896	42364896	C	G	Missense_Mutation		2
RPS19	CESC	chr19	42365220	42365220	C	A	Silent		2
RPS19	HNSC	chr19	42373230	42373230	G	A	Missense_Mutation	p.R101H	2
RPS19	CESC	chr19	42364871	42364871	G	C	Silent		2
RPS19	UCEC	chr19	42373817	42373817	C	G	Silent	p.A135A	1
RPS19	LGG	chr19	42365246	42365246	C	A	Missense_Mutation	p.A46D	1
RPS19	CESC	chr19	42364871	42364871	G	C	Silent	p.V9	1
RPS19	LGG	chr19	42365246	42365246	C	A	Missense_Mutation		1
RPS19	CESC	chr19	42365220	42365220	C	A	Silent	p.V37	1
RPS19	LIHC	chr19	42364911	42364911	A	-	Frame_Shift_Del	p.K24fs	1
RPS19	ESCA	chr19	42364855	42364855	T	-	Frame_Shift_Del	p.T5fs	1
RPS19	LUAD	chr19	42373137	42373137	C	T	Missense_Mutation	p.A70V	1
RPS19	SARC	chr19	42365245	42365245	G	T	Missense_Mutation		1
RPS19	SARC	chr19	42373100	42373100	G	T	Splice_Site		1
RPS19	ESCA	chr19	42364858	42364858	C	A	Missense_Mutation		1
RPS19	SKCM	chr19	42373208	42373208	C	T	Nonsense_Mutation	p.R94*	1
RPS19	HNSC	chr19	42373230	42373230	G	A	Missense_Mutation		1
RPS19	SKCM	chr19	42373237	42373237	C	T	Silent	p.V103V	1
RPS19	THCA	chr19	42373229	42373229	C	A	Missense_Mutation		1

Copy number variation (CNV) of RPS19
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS19
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
85779	BRCA	TCGA-BH-A0BL-01A	AGPAT3	chr21	45323900	+	RPS19	chr19	42364204	+
85779	READ	TCGA-F5-6814	ARHGEF1	chr19	42397374	+	RPS19	chr19	42367941	+
85779	READ	TCGA-F5-6814	ARHGEF1	chr19	42397374	+	RPS19	chr19	42373100	+
85779	READ	TCGA-F5-6814-01A	ARHGEF1	chr19	42397374	+	RPS19	chr19	42373101	+
85779	N/A	T11633	CAP1	chr1	40538241	+	RPS19	chr19	42373298	-
85779	READ	UNCID	CEACAM7	chr19	42181993	-	RPS19	chr19	42365280	-
85779	READ	UNCID	CEACAM7	chr19	42189764	-	RPS19	chr19	42365280	-
85779	BRCA	TCGA-A7-A6VV-01A	CIC	chr19	42772746	+	RPS19	chr19	42373101	+
85779	BLCA	TCGA-FJ-A3Z7-01A	PAPPA2	chr1	176640251	+	RPS19	chr19	42373101	+
85779	N/A	BQ351523	PLD1	chr3	171510388	+	RPS19	chr19	42373208	-
85779	N/A	BU602070	RPS14	chr5	149826368	-	RPS19	chr19	42373271	+
77551	N/A	BF245330	RPS19	chr19	42375484	+	ABHD12B	chr14	51366638	+
77551	READ	TCGA-EI-6506	RPS19	chr19	42365281	+	CEA	chr19	42213599	+
77551	READ	TCGA-EI-6506	RPS19	chr19	42365281	+	CEA	chr19	42260508	+
77551	STAD	TCGA-BR-A4J1	RPS19	chr19	42365281	+	CEACAM3	chr19	42314002	+
77551	STAD	TCGA-BR-A4J1	RPS19	chr19	42365281	+	CEACAM3	chr19	42314360	+
77551	STAD	TCGA-BR-A4J1-01A	RPS19	chr19	42365281	-	CEACAM3	chr19	42314003	+
99854	LUSC	TCGA-58-8387	RPS19	chr19	42365281	+	CEACAM5	chr19	42224841	+
99854	LUSC	TCGA-58-8387	RPS19	chr19	42365281	+	CEACAM5	chr19	42224842	+
99854	LUSC	TCGA-58-8387	RPS19	chr19	42365281	+	CEACAM5	chr19	42231153	+
99854	LUSC	TCGA-58-8387	RPS19	chr19	42365281	+	CEACAM5	chr19	42231154	+
99854	LUSC	TCGA-58-8387-01A	RPS19	chr19	42365280	+	CEACAM5	chr19	42224841	+
99854	READ	TCGA-EI-6506	RPS19	chr19	42365281	+	CEACAM5	chr19	42213598	+
99854	READ	TCGA-EI-6506	RPS19	chr19	42365281	+	CEACAM5	chr19	42213599	+
77551	SKCM	TCGA-ER-A19L-06A	RPS19	chr19	42365281	+	CEACAM6	chr19	42274707	+
102007	N/A	BF217618	RPS19	chr19	42375481	+	CREBBP	chr16	3787472	-
91103	COAD	TCGA-AA-3548-01A	RPS19	chr19	42373284	+	CYBA	chr16	88709928	-
88320	N/A	DB116923	RPS19	chr19	42365223	+	DCAF8	chr1	160209683	-
77551	BRCA	TCGA-A8-A07G-01A	RPS19	chr19	42365280	+	DMRTC2	chr19	42354593	+
77551	BRCA	TCGA-A8-A07G-01A	RPS19	chr19	42365281	+	DMRTC2	chr19	42354380	+
77551	BRCA	TCGA-A8-A07G-01A	RPS19	chr19	42365281	+	DMRTC2	chr19	42354594	+
77551	LUAD	TCGA-53-7624-01A	RPS19	chr19	42373823	+	DMRTC2	chr19	42352863	+
102562	UCEC	TCGA-H5-A2HR	RPS19	chr19	42365281	+	FXYD5	chr19	35660468	+
102278	STAD	TCGA-BR-8078-01A	RPS19	chr19	42365281	+	HNRNPUL1	chr19	41774128	+
96045	OV	TCGA-24-1923	RPS19	chr19	42365281	+	INTS10	chr8	19703214	+
91140	N/A	DL059649	RPS19	chr19	42375503	+	KCNH7	chr2	163583812	-
77551	N/A	BE737590	RPS19	chr19	42375480	+	LINC00959	chr10	131874270	-
101792	N/A	AV694187	RPS19	chr19	42375484	+	PDE4D	chr5	58445548	-
102598	OV	TCGA-04-1350	RPS19	chr19	42365281	+	PRKCSH	chr19	11561460	+
103203	N/A	AW300778	RPS19	chr19	42364325	-	RPS4Y1	chrY	2734859	+
80339	Non-Cancer	TCGA-BR-6564-11A	RPS19	chr19	42373823	+	SLC6A19	chr5	1221266	+
98716	N/A	EC444832	RPS19	chr19	42373782	+	SNX6	chr14	35038056	-
98716	N/A	NM_001022	RPS19	chr19	42375484	+	SNX6	chr14	35038375	-
98716	N/A	NM_001321483	RPS19	chr19	42375484	+	SNX6	chr14	35038336	-
77551	N/A	FN100630	RPS19	chr19	42373768	-	TET1	chr10	70348303	-
77551	OV	TCGA-10-0934	RPS19	chr19	42365281	+	THOC7	chr3	63825449	-
85779	N/A	AA365173	SPICE1	chr3	113186735	+	RPS19	chr19	42373175	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	RPS19	0.00455192862938489	0.13
COAD	RPS19	0.00594833193154448	0.16
KIRC	RPS19	0.0124508793889151	0.32

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPS19	0.0337763003415563	1
BRCA	RPS19	9.18212802156538e-06	3e-04
PAAD	RPS19	0.00497507626299987	0.16
SARC	RPS19	0.0249944804005603	0.77

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C2676137	Diamond-Blackfan Anemia 1	9	GENOMICS_ENGLAND;UNIPROT
C1260899	Anemia, Diamond-Blackfan	3	CTD_human;GENOMICS_ENGLAND
C0241397	Triphalangeal thumb	2	GENOMICS_ENGLAND
C0431890	Hypoplasia of thumb	2	GENOMICS_ENGLAND
C3278811	Thumb aplasia	2	GENOMICS_ENGLAND
C0024623	Malignant neoplasm of stomach	1	CTD_human
C0376358	Malignant neoplasm of prostate	1	CTD_human
C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human