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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS20 (NCBI Gene ID:6224)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS20
	Gene ID: 6224
	Gene Symbol	RPS20
	Gene ID	6224
	Gene Name	ribosomal protein S20
	Synonyms	S20\|uS10
	Cytomap	8q12.1
	Type of Gene	protein-coding
	Description	40S ribosomal protein S20small ribosomal subunit protein uS10
	Modification date	20200327
	UniProtAcc	P60866

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS20	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS20[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS20	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000009589	56986253	56986327	Frame-shift
ENST00000521262	56986253	56986327	Frame-shift
ENST00000009589	56986618	56986718	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
COAD	RPS20	-3.55214827660447	0.0010443925857544
KICH	RPS20	-2.30757233561727	0.00612920522689819
BLCA	RPS20	-3.2869410015055	0.0360679626464844
KIRP	RPS20	-1.44580921357944	1.60322524607182e-05
KIRC	RPS20	-2.62380824779569	7.86590430905899e-10

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
READ	RPS20	-0.08815612	0.007171148
PRAD	RPS20	-0.076974069	0.017024684
CESC	RPS20	0.075091655	0.025638011
MESO	RPS20	0.059145866	0.035854191

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS20 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	RPS20	FAU	0.825789854	2.92E-12
CHOL	Cell metabolism gene	RPS20	PFDN5	0.845814884	2.62E-13
DLBC	Cell metabolism gene	RPS20	PFDN5	0.846947228	3.29E-14
DLBC	Cell metabolism gene	RPS20	FAU	0.862970882	3.09E-15
DLBC	CGC	RPS20	NACA	0.805020466	5.33E-12
DLBC	TF	RPS20	ZNF581	0.828532427	3.63E-13
DLBC	TSG	RPS20	GLTSCR2	0.818556615	1.19E-12
DLBC	TSG	RPS20	GNB2L1	0.896728238	6.75E-18
GBM	Cell metabolism gene	RPS20	SSR4	0.807894114	6.89E-41
GBM	Cell metabolism gene	RPS20	LSM1	0.813454337	7.32E-42
KIRP	Cell metabolism gene	RPS20	FAU	0.856088782	5.01E-94
KIRP	Cell metabolism gene	RPS20	PFDN5	0.863174369	2.77E-97
KIRP	Cell metabolism gene	RPS20	SNRPD2	0.87410503	1.10E-102
KIRP	TSG	RPS20	GADD45GIP1	0.820832034	4.52E-80
LGG	Cell metabolism gene	RPS20	FAU	0.876900111	4.11E-170
LGG	CGC	RPS20	NACA	0.808243839	1.56E-123
LGG	TSG	RPS20	GAS5	0.806567631	1.22E-122
MESO	Cell metabolism gene	RPS20	FAU	0.803992523	6.91E-21
PAAD	Cell metabolism gene	RPS20	FAU	0.801869728	2.42E-42
PCPG	Cell metabolism gene	RPS20	PFDN5	0.824339319	1.37E-47
PRAD	Cell metabolism gene	RPS20	SNRPD2	0.801337221	2.21E-124
PRAD	Cell metabolism gene	RPS20	PFDN5	0.817577004	1.80E-133
PRAD	Cell metabolism gene	RPS20	TOMM7	0.836132917	4.90E-145
PRAD	Cell metabolism gene	RPS20	FAU	0.841235627	1.79E-148
THCA	Cell metabolism gene	RPS20	DGUOK	0.820968965	7.58E-141
THCA	Cell metabolism gene	RPS20	POLR2I	0.822475983	8.61E-142
THCA	Cell metabolism gene	RPS20	PFDN5	0.868113121	1.56E-175
THCA	Cell metabolism gene	RPS20	SNRPD2	0.901483688	1.82E-209
THCA	Cell metabolism gene	RPS20	FAU	0.901551482	1.51E-209
THCA	Epifactor	RPS20	FBL	0.806806422	2.21E-132
THCA	Epifactor	RPS20	TAF10	0.84384144	3.12E-156
THCA	IUPHAR	RPS20	CSNK2B	0.820834283	9.20E-141
THCA	TF	RPS20	ZNF524	0.802802162	4.08E-130
THCA	TSG	RPS20	AIP	0.8164979	4.28E-138
THCA	TSG	RPS20	GADD45GIP1	0.816971875	2.20E-138
THCA	TSG	RPS20	GNB2L1	0.851247975	9.39E-162
THYM	Cell metabolism gene	RPS20	OAZ1	0.801508435	1.44E-28
THYM	Cell metabolism gene	RPS20	PGP	0.802780264	1.02E-28
THYM	Cell metabolism gene	RPS20	TXN	0.803387501	8.64E-29
THYM	Cell metabolism gene	RPS20	LSM3	0.807591743	2.70E-29
THYM	Cell metabolism gene	RPS20	NANS	0.808389355	2.16E-29
THYM	Cell metabolism gene	RPS20	GEMIN6	0.809746948	1.47E-29
THYM	Cell metabolism gene	RPS20	HMBS	0.811004928	1.03E-29
THYM	Cell metabolism gene	RPS20	MTMR14	0.812248734	7.21E-30
THYM	Cell metabolism gene	RPS20	PSMC1	0.812696963	6.34E-30
THYM	Cell metabolism gene	RPS20	PSME2	0.813519489	5.00E-30
THYM	Cell metabolism gene	RPS20	TOMM40	0.813609101	4.87E-30
THYM	Cell metabolism gene	RPS20	TAZ	0.814073042	4.25E-30
THYM	Cell metabolism gene	RPS20	PSME1	0.814255285	4.03E-30
THYM	Cell metabolism gene	RPS20	GMPPA	0.814325224	3.95E-30
THYM	Cell metabolism gene	RPS20	POLD4	0.814784248	3.46E-30
THYM	Cell metabolism gene	RPS20	UROD	0.818209914	1.26E-30
THYM	Cell metabolism gene	RPS20	GEMIN7	0.818447497	1.17E-30
THYM	Cell metabolism gene	RPS20	MTX1	0.820671544	6.00E-31
THYM	Cell metabolism gene	RPS20	TBCB	0.820827647	5.73E-31
THYM	Cell metabolism gene	RPS20	EXOSC1	0.823180834	2.79E-31
THYM	Cell metabolism gene	RPS20	FPGS	0.824357124	1.94E-31
THYM	Cell metabolism gene	RPS20	MVD	0.82490772	1.64E-31
THYM	Cell metabolism gene	RPS20	PSMD4	0.825039368	1.57E-31
THYM	Cell metabolism gene	RPS20	EXOSC5	0.826191521	1.10E-31
THYM	Cell metabolism gene	RPS20	TIMM17B	0.826770509	9.14E-32
THYM	Cell metabolism gene	RPS20	LSM5	0.826835272	8.95E-32
THYM	Cell metabolism gene	RPS20	PSMB1	0.828038181	6.12E-32
THYM	Cell metabolism gene	RPS20	TOMM22	0.828895848	4.66E-32
THYM	Cell metabolism gene	RPS20	SEC61G	0.829228361	4.19E-32
THYM	Cell metabolism gene	RPS20	SRM	0.829559549	3.77E-32
THYM	Cell metabolism gene	RPS20	TIMM10	0.83038283	2.89E-32
THYM	Cell metabolism gene	RPS20	SEC61B	0.833827908	9.42E-33
THYM	Cell metabolism gene	RPS20	SNRPF	0.836419408	3.98E-33
THYM	Cell metabolism gene	RPS20	WBSCR22	0.836473586	3.91E-33
THYM	Cell metabolism gene	RPS20	SMPD2	0.837161424	3.10E-33
THYM	Cell metabolism gene	RPS20	PSMB10	0.83779764	2.50E-33
THYM	Cell metabolism gene	RPS20	PFDN6	0.839883556	1.23E-33
THYM	Cell metabolism gene	RPS20	EXOSC4	0.842610112	4.78E-34
THYM	Cell metabolism gene	RPS20	LSM4	0.847126069	9.59E-35
THYM	Cell metabolism gene	RPS20	SNRPD3	0.852483995	1.33E-35
THYM	Cell metabolism gene	RPS20	DGUOK	0.853337612	9.67E-36
THYM	Cell metabolism gene	RPS20	DPM2	0.853377758	9.52E-36
THYM	Cell metabolism gene	RPS20	PHKG2	0.858385592	1.38E-36
THYM	Cell metabolism gene	RPS20	EBP	0.860852079	5.21E-37
THYM	Cell metabolism gene	RPS20	IDH3G	0.861354148	4.26E-37
THYM	Cell metabolism gene	RPS20	LSM2	0.861601347	3.85E-37
THYM	Cell metabolism gene	RPS20	ITPA	0.861781763	3.58E-37
THYM	Cell metabolism gene	RPS20	PSMD13	0.862115632	3.13E-37
THYM	Cell metabolism gene	RPS20	TIMM50	0.866405341	5.37E-38
THYM	Cell metabolism gene	RPS20	PSMC3	0.869141864	1.69E-38
THYM	Cell metabolism gene	RPS20	DPM3	0.87054761	9.23E-39
THYM	Cell metabolism gene	RPS20	ACOT8	0.871866883	5.20E-39
THYM	Cell metabolism gene	RPS20	TIMM13	0.872183691	4.53E-39
THYM	Cell metabolism gene	RPS20	POLR2I	0.873017455	3.14E-39
THYM	Cell metabolism gene	RPS20	GUK1	0.874330363	1.75E-39
THYM	Cell metabolism gene	RPS20	SSR2	0.876276637	7.29E-40
THYM	Cell metabolism gene	RPS20	POLR2H	0.877011598	5.21E-40
THYM	Cell metabolism gene	RPS20	POLR2F	0.878476643	2.66E-40
THYM	Cell metabolism gene	RPS20	PSMB7	0.881066876	7.90E-41
THYM	Cell metabolism gene	RPS20	APRT	0.883668797	2.27E-41
THYM	Cell metabolism gene	RPS20	PSMB3	0.883952145	1.98E-41
THYM	Cell metabolism gene	RPS20	POLR2J	0.884434434	1.56E-41
THYM	Cell metabolism gene	RPS20	PGLS	0.895377292	5.60E-44
THYM	Cell metabolism gene	RPS20	SLC27A5	0.895699024	4.70E-44
THYM	Cell metabolism gene	RPS20	PFDN5	0.912655552	1.87E-48
THYM	Cell metabolism gene	RPS20	TIMM8B	0.914186123	6.80E-49
THYM	Cell metabolism gene	RPS20	SNRPD2	0.916021539	1.96E-49
THYM	Cell metabolism gene	RPS20	FAU	0.954684616	5.26E-65
THYM	CGC	RPS20	COX6C	0.815472954	2.83E-30
THYM	CGC	RPS20	MGMT	0.822723002	3.21E-31
THYM	CGC	RPS20	SDHAF2	0.839468011	1.42E-33
THYM	CGC	RPS20	RBM10	0.84453288	2.43E-34
THYM	CGC	RPS20	TFPT	0.870552393	9.21E-39
THYM	Epifactor	RPS20	HIST2H2AC	0.800142845	2.08E-28
THYM	Epifactor	RPS20	CXXC1	0.800371032	1.96E-28
THYM	Epifactor	RPS20	LAS1L	0.802186438	1.20E-28
THYM	Epifactor	RPS20	DMAP1	0.815335796	2.94E-30
THYM	Epifactor	RPS20	ZGPAT	0.815577055	2.74E-30
THYM	Epifactor	RPS20	EXOSC1	0.823180834	2.79E-31
THYM	Epifactor	RPS20	NOC2L	0.825271125	1.46E-31
THYM	Epifactor	RPS20	EXOSC5	0.826191521	1.10E-31
THYM	Epifactor	RPS20	MBD3	0.828385878	5.48E-32
THYM	Epifactor	RPS20	RBX1	0.833313213	1.12E-32
THYM	Epifactor	RPS20	RUVBL2	0.837696283	2.59E-33
THYM	Epifactor	RPS20	EXOSC4	0.842610112	4.78E-34
THYM	Epifactor	RPS20	PPP4C	0.854402769	6.46E-36
THYM	Epifactor	RPS20	SS18L2	0.85928298	9.72E-37
THYM	Epifactor	RPS20	PRPF31	0.8639416	1.49E-37
THYM	Epifactor	RPS20	TFPT	0.870552393	9.21E-39
THYM	Epifactor	RPS20	FBL	0.873377633	2.67E-39
THYM	Epifactor	RPS20	INO80E	0.874566586	1.58E-39
THYM	Epifactor	RPS20	CCDC101	0.879312566	1.80E-40
THYM	Epifactor	RPS20	C17orf49	0.889071484	1.55E-42
THYM	Epifactor	RPS20	BRMS1	0.904397556	3.30E-46
THYM	Epifactor	RPS20	SIRT6	0.907537814	4.89E-47
THYM	Epifactor	RPS20	ZNHIT1	0.908978296	1.99E-47
THYM	Epifactor	RPS20	TAF10	0.938854883	2.10E-57
THYM	IUPHAR	RPS20	RNPEPL1	0.804535528	6.31E-29
THYM	IUPHAR	RPS20	SIRT3	0.804840898	5.80E-29
THYM	IUPHAR	RPS20	MVD	0.82490772	1.64E-31
THYM	IUPHAR	RPS20	PSMB1	0.828038181	6.12E-32
THYM	IUPHAR	RPS20	MMP24	0.835376847	5.64E-33
THYM	IUPHAR	RPS20	SMPD2	0.837161424	3.10E-33
THYM	IUPHAR	RPS20	PPIA	0.840862059	8.77E-34
THYM	IUPHAR	RPS20	PHKG2	0.858385592	1.38E-36
THYM	IUPHAR	RPS20	SLC27A5	0.895699024	4.70E-44
THYM	IUPHAR	RPS20	SIRT6	0.907537814	4.89E-47
THYM	Kinase	RPS20	PHKG2	0.858385592	1.38E-36
THYM	TF	RPS20	CXXC1	0.800371032	1.96E-28
THYM	TF	RPS20	USF2	0.804473984	6.42E-29
THYM	TF	RPS20	ZNF668	0.808617857	2.03E-29
THYM	TF	RPS20	AKAP8L	0.810418073	1.22E-29
THYM	TF	RPS20	ZGPAT	0.815577055	2.74E-30
THYM	TF	RPS20	USF1	0.816514735	2.08E-30
THYM	TF	RPS20	ZNF511	0.820025623	7.30E-31
THYM	TF	RPS20	ZNF32	0.823208266	2.77E-31
THYM	TF	RPS20	RBCK1	0.824607299	1.80E-31
THYM	TF	RPS20	GLI4	0.825574102	1.33E-31
THYM	TF	RPS20	MBD3	0.828385878	5.48E-32
THYM	TF	RPS20	ZNF524	0.834723452	7.00E-33
THYM	TF	RPS20	ETV2	0.836121589	4.40E-33
THYM	TF	RPS20	THAP7	0.837175769	3.09E-33
THYM	TF	RPS20	ZNF444	0.837410628	2.85E-33
THYM	TF	RPS20	IRF3	0.839589118	1.36E-33
THYM	TF	RPS20	ZNF688	0.850458055	2.84E-35
THYM	TF	RPS20	THYN1	0.85093792	2.38E-35
THYM	TF	RPS20	THAP3	0.856074133	3.40E-36
THYM	TF	RPS20	ZNF787	0.860827641	5.26E-37
THYM	TF	RPS20	DRAP1	0.869317947	1.57E-38
THYM	TF	RPS20	ZNF428	0.876256934	7.35E-40
THYM	TSG	RPS20	PLEKHO1	0.8029551	9.72E-29
THYM	TSG	RPS20	SIRT3	0.804840898	5.80E-29
THYM	TSG	RPS20	HTRA2	0.80815302	2.31E-29
THYM	TSG	RPS20	ZNF668	0.808617857	2.03E-29
THYM	TSG	RPS20	AIP	0.837916032	2.40E-33
THYM	TSG	RPS20	IRF3	0.839589118	1.36E-33
THYM	TSG	RPS20	ST20	0.84536278	1.81E-34
THYM	TSG	RPS20	PFN1	0.85029894	3.01E-35
THYM	TSG	RPS20	PARK7	0.85566839	3.98E-36
THYM	TSG	RPS20	TSSC4	0.857453138	1.99E-36
THYM	TSG	RPS20	GABARAP	0.859639728	8.44E-37
THYM	TSG	RPS20	GLTSCR2	0.881291038	7.11E-41
THYM	TSG	RPS20	NPRL2	0.885147182	1.10E-41
THYM	TSG	RPS20	GADD45GIP1	0.885253768	1.05E-41
THYM	TSG	RPS20	GNB2L1	0.897196103	2.07E-44
THYM	TSG	RPS20	BRMS1	0.904397556	3.30E-46
THYM	TSG	RPS20	SIRT6	0.907537814	4.89E-47
UCS	Cell metabolism gene	RPS20	OAZ1	0.801508435	1.44E-28
UCS	Cell metabolism gene	RPS20	PGP	0.802780264	1.02E-28
UCS	Cell metabolism gene	RPS20	TXN	0.803387501	8.64E-29
UCS	Cell metabolism gene	RPS20	LSM3	0.807591743	2.70E-29
UCS	Cell metabolism gene	RPS20	NANS	0.808389355	2.16E-29
UCS	Cell metabolism gene	RPS20	GEMIN6	0.809746948	1.47E-29
UCS	Cell metabolism gene	RPS20	HMBS	0.811004928	1.03E-29
UCS	Cell metabolism gene	RPS20	MTMR14	0.812248734	7.21E-30
UCS	Cell metabolism gene	RPS20	PSMC1	0.812696963	6.34E-30
UCS	Cell metabolism gene	RPS20	PSME2	0.813519489	5.00E-30
UCS	Cell metabolism gene	RPS20	TOMM40	0.813609101	4.87E-30
UCS	Cell metabolism gene	RPS20	TAZ	0.814073042	4.25E-30
UCS	Cell metabolism gene	RPS20	PSME1	0.814255285	4.03E-30
UCS	Cell metabolism gene	RPS20	GMPPA	0.814325224	3.95E-30
UCS	Cell metabolism gene	RPS20	POLD4	0.814784248	3.46E-30
UCS	Cell metabolism gene	RPS20	UROD	0.818209914	1.26E-30
UCS	Cell metabolism gene	RPS20	GEMIN7	0.818447497	1.17E-30
UCS	Cell metabolism gene	RPS20	MTX1	0.820671544	6.00E-31
UCS	Cell metabolism gene	RPS20	TBCB	0.820827647	5.73E-31
UCS	Cell metabolism gene	RPS20	EXOSC1	0.823180834	2.79E-31
UCS	Cell metabolism gene	RPS20	FPGS	0.824357124	1.94E-31
UCS	Cell metabolism gene	RPS20	MVD	0.82490772	1.64E-31
UCS	Cell metabolism gene	RPS20	PSMD4	0.825039368	1.57E-31
UCS	Cell metabolism gene	RPS20	EXOSC5	0.826191521	1.10E-31
UCS	Cell metabolism gene	RPS20	TIMM17B	0.826770509	9.14E-32
UCS	Cell metabolism gene	RPS20	LSM5	0.826835272	8.95E-32
UCS	Cell metabolism gene	RPS20	PSMB1	0.828038181	6.12E-32
UCS	Cell metabolism gene	RPS20	TOMM22	0.828895848	4.66E-32
UCS	Cell metabolism gene	RPS20	SEC61G	0.829228361	4.19E-32
UCS	Cell metabolism gene	RPS20	SRM	0.829559549	3.77E-32
UCS	Cell metabolism gene	RPS20	TIMM10	0.83038283	2.89E-32
UCS	Cell metabolism gene	RPS20	SEC61B	0.833827908	9.42E-33
UCS	Cell metabolism gene	RPS20	SNRPF	0.836419408	3.98E-33
UCS	Cell metabolism gene	RPS20	WBSCR22	0.836473586	3.91E-33
UCS	Cell metabolism gene	RPS20	SMPD2	0.837161424	3.10E-33
UCS	Cell metabolism gene	RPS20	PSMB10	0.83779764	2.50E-33
UCS	Cell metabolism gene	RPS20	PFDN6	0.839883556	1.23E-33
UCS	Cell metabolism gene	RPS20	EXOSC4	0.842610112	4.78E-34
UCS	Cell metabolism gene	RPS20	LSM4	0.847126069	9.59E-35
UCS	Cell metabolism gene	RPS20	SNRPD3	0.852483995	1.33E-35
UCS	Cell metabolism gene	RPS20	DGUOK	0.853337612	9.67E-36
UCS	Cell metabolism gene	RPS20	DPM2	0.853377758	9.52E-36
UCS	Cell metabolism gene	RPS20	PHKG2	0.858385592	1.38E-36
UCS	Cell metabolism gene	RPS20	EBP	0.860852079	5.21E-37
UCS	Cell metabolism gene	RPS20	IDH3G	0.861354148	4.26E-37
UCS	Cell metabolism gene	RPS20	LSM2	0.861601347	3.85E-37
UCS	Cell metabolism gene	RPS20	ITPA	0.861781763	3.58E-37
UCS	Cell metabolism gene	RPS20	PSMD13	0.862115632	3.13E-37
UCS	Cell metabolism gene	RPS20	TIMM50	0.866405341	5.37E-38
UCS	Cell metabolism gene	RPS20	PSMC3	0.869141864	1.69E-38
UCS	Cell metabolism gene	RPS20	DPM3	0.87054761	9.23E-39
UCS	Cell metabolism gene	RPS20	ACOT8	0.871866883	5.20E-39
UCS	Cell metabolism gene	RPS20	TIMM13	0.872183691	4.53E-39
UCS	Cell metabolism gene	RPS20	POLR2I	0.873017455	3.14E-39
UCS	Cell metabolism gene	RPS20	GUK1	0.874330363	1.75E-39
UCS	Cell metabolism gene	RPS20	SSR2	0.876276637	7.29E-40
UCS	Cell metabolism gene	RPS20	POLR2H	0.877011598	5.21E-40
UCS	Cell metabolism gene	RPS20	POLR2F	0.878476643	2.66E-40
UCS	Cell metabolism gene	RPS20	PSMB7	0.881066876	7.90E-41
UCS	Cell metabolism gene	RPS20	APRT	0.883668797	2.27E-41
UCS	Cell metabolism gene	RPS20	PSMB3	0.883952145	1.98E-41
UCS	Cell metabolism gene	RPS20	POLR2J	0.884434434	1.56E-41
UCS	Cell metabolism gene	RPS20	PGLS	0.895377292	5.60E-44
UCS	Cell metabolism gene	RPS20	SLC27A5	0.895699024	4.70E-44
UCS	Cell metabolism gene	RPS20	PFDN5	0.912655552	1.87E-48
UCS	Cell metabolism gene	RPS20	TIMM8B	0.914186123	6.80E-49
UCS	Cell metabolism gene	RPS20	SNRPD2	0.916021539	1.96E-49
UCS	Cell metabolism gene	RPS20	FAU	0.954684616	5.26E-65
UCS	CGC	RPS20	COX6C	0.815472954	2.83E-30
UCS	CGC	RPS20	MGMT	0.822723002	3.21E-31
UCS	CGC	RPS20	SDHAF2	0.839468011	1.42E-33
UCS	CGC	RPS20	RBM10	0.84453288	2.43E-34
UCS	CGC	RPS20	TFPT	0.870552393	9.21E-39
UCS	Epifactor	RPS20	HIST2H2AC	0.800142845	2.08E-28
UCS	Epifactor	RPS20	CXXC1	0.800371032	1.96E-28
UCS	Epifactor	RPS20	LAS1L	0.802186438	1.20E-28
UCS	Epifactor	RPS20	DMAP1	0.815335796	2.94E-30
UCS	Epifactor	RPS20	ZGPAT	0.815577055	2.74E-30
UCS	Epifactor	RPS20	EXOSC1	0.823180834	2.79E-31
UCS	Epifactor	RPS20	NOC2L	0.825271125	1.46E-31
UCS	Epifactor	RPS20	EXOSC5	0.826191521	1.10E-31
UCS	Epifactor	RPS20	MBD3	0.828385878	5.48E-32
UCS	Epifactor	RPS20	RBX1	0.833313213	1.12E-32
UCS	Epifactor	RPS20	RUVBL2	0.837696283	2.59E-33
UCS	Epifactor	RPS20	EXOSC4	0.842610112	4.78E-34
UCS	Epifactor	RPS20	PPP4C	0.854402769	6.46E-36
UCS	Epifactor	RPS20	SS18L2	0.85928298	9.72E-37
UCS	Epifactor	RPS20	PRPF31	0.8639416	1.49E-37
UCS	Epifactor	RPS20	TFPT	0.870552393	9.21E-39
UCS	Epifactor	RPS20	FBL	0.873377633	2.67E-39
UCS	Epifactor	RPS20	INO80E	0.874566586	1.58E-39
UCS	Epifactor	RPS20	CCDC101	0.879312566	1.80E-40
UCS	Epifactor	RPS20	C17orf49	0.889071484	1.55E-42
UCS	Epifactor	RPS20	BRMS1	0.904397556	3.30E-46
UCS	Epifactor	RPS20	SIRT6	0.907537814	4.89E-47
UCS	Epifactor	RPS20	ZNHIT1	0.908978296	1.99E-47
UCS	Epifactor	RPS20	TAF10	0.938854883	2.10E-57
UCS	IUPHAR	RPS20	RNPEPL1	0.804535528	6.31E-29
UCS	IUPHAR	RPS20	SIRT3	0.804840898	5.80E-29
UCS	IUPHAR	RPS20	MVD	0.82490772	1.64E-31
UCS	IUPHAR	RPS20	PSMB1	0.828038181	6.12E-32
UCS	IUPHAR	RPS20	MMP24	0.835376847	5.64E-33
UCS	IUPHAR	RPS20	SMPD2	0.837161424	3.10E-33
UCS	IUPHAR	RPS20	PPIA	0.840862059	8.77E-34
UCS	IUPHAR	RPS20	PHKG2	0.858385592	1.38E-36
UCS	IUPHAR	RPS20	SLC27A5	0.895699024	4.70E-44
UCS	IUPHAR	RPS20	SIRT6	0.907537814	4.89E-47
UCS	Kinase	RPS20	PHKG2	0.858385592	1.38E-36
UCS	TF	RPS20	CXXC1	0.800371032	1.96E-28
UCS	TF	RPS20	USF2	0.804473984	6.42E-29
UCS	TF	RPS20	ZNF668	0.808617857	2.03E-29
UCS	TF	RPS20	AKAP8L	0.810418073	1.22E-29
UCS	TF	RPS20	ZGPAT	0.815577055	2.74E-30
UCS	TF	RPS20	USF1	0.816514735	2.08E-30
UCS	TF	RPS20	ZNF511	0.820025623	7.30E-31
UCS	TF	RPS20	ZNF32	0.823208266	2.77E-31
UCS	TF	RPS20	RBCK1	0.824607299	1.80E-31
UCS	TF	RPS20	GLI4	0.825574102	1.33E-31
UCS	TF	RPS20	MBD3	0.828385878	5.48E-32
UCS	TF	RPS20	ZNF524	0.834723452	7.00E-33
UCS	TF	RPS20	ETV2	0.836121589	4.40E-33
UCS	TF	RPS20	THAP7	0.837175769	3.09E-33
UCS	TF	RPS20	ZNF444	0.837410628	2.85E-33
UCS	TF	RPS20	IRF3	0.839589118	1.36E-33
UCS	TF	RPS20	ZNF688	0.850458055	2.84E-35
UCS	TF	RPS20	THYN1	0.85093792	2.38E-35
UCS	TF	RPS20	THAP3	0.856074133	3.40E-36
UCS	TF	RPS20	ZNF787	0.860827641	5.26E-37
UCS	TF	RPS20	DRAP1	0.869317947	1.57E-38
UCS	TF	RPS20	ZNF428	0.876256934	7.35E-40
UCS	TSG	RPS20	PLEKHO1	0.8029551	9.72E-29
UCS	TSG	RPS20	SIRT3	0.804840898	5.80E-29
UCS	TSG	RPS20	HTRA2	0.80815302	2.31E-29
UCS	TSG	RPS20	ZNF668	0.808617857	2.03E-29
UCS	TSG	RPS20	AIP	0.837916032	2.40E-33
UCS	TSG	RPS20	IRF3	0.839589118	1.36E-33
UCS	TSG	RPS20	ST20	0.84536278	1.81E-34
UCS	TSG	RPS20	PFN1	0.85029894	3.01E-35
UCS	TSG	RPS20	PARK7	0.85566839	3.98E-36
UCS	TSG	RPS20	TSSC4	0.857453138	1.99E-36
UCS	TSG	RPS20	GABARAP	0.859639728	8.44E-37
UCS	TSG	RPS20	GLTSCR2	0.881291038	7.11E-41
UCS	TSG	RPS20	NPRL2	0.885147182	1.10E-41
UCS	TSG	RPS20	GADD45GIP1	0.885253768	1.05E-41
UCS	TSG	RPS20	GNB2L1	0.897196103	2.07E-44
UCS	TSG	RPS20	BRMS1	0.904397556	3.30E-46
UCS	TSG	RPS20	SIRT6	0.907537814	4.89E-47

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS20	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS20	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS20	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPS20	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS20	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS20	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS20	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS20	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS20	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS20	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS20	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPS20	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS20	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS20	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS20	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS20	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPS20	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS20	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPS20	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPS20	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS20	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS20	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS20	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS20	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPS20	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPS20	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS20	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS20	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS20

UBC, PIK3CA, NRAS, PLEKHO1, RAD21, NDRG1, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, NEDD8, MDM2, GRB2, RPS4X, APP, RPL10A, RPL11, RPL12, RPL15, RPL18A, RPL21, RPL24, RPL4, RPL6, RPL7A, RPL9, RPS23, RPS25, RPS6, RPS8, RPS2, RPL14, RPS3, RPL3, RPL5, RPL8, RPL27A, RPL23A, RPL18, RPS26, RPS3A, RPL23, RPS28, RPL7, RPS16, RPL19, RPSA, RPL13, RPLP2, RPL37A, RPS15A, RPL35, RPS13, RPS19, RPLP0, RPL17, RPL32, RPS21, RPL29, ILF2, TUFM, ILF3, RPS27L, RPLP0P6, DHX38, SND1, MAP4, MRPL23, POLR2A, HSP90AA1, TCP1, DDX5, PGRMC1, COG4, MRPL14, RALY, SYNCRIP, ESR1, BARD1, ECT2, PAXIP1, SMURF1, FN1, VCAM1, IL7R, UBL4A, ITGA4, MDM4, SUN2, RABAC1, REEP6, MPP6, AGO2, FBXO6, TARDBP, PARK2, EIF3A, EIF3CL, EIF3E, PNO1, RPS10, RPS11, RPS12, RPS14, RPS17, RPS18, EIF3D, EIF3L, EIF3H, FAU, GNB2L1, RPS24, RPS29, RPS5, RPS7, RPS9, RPS27, SERBP1, TSR1, WIBG, TUBGCP2, LGALS3, EEFSEC, HBS1L, MRPL1, RPL10, RPL13A, RPL22, RPL27, RPL30, RPL31, RPL34, RPL35A, RPL38, RPLP1, RPL36, RPL3L, LOC101929876, RRP7A, UBA52, SFN, PTEN, HIST1H3E, AHSA1, NPM1, CBX8, EXOSC1, Eif3a, Eif3e, Bcas2, Rrbp1, MCM2, Ksr1, RC3H1, EGFR, RRS1, HIST1H1E, NCL, CYLD, TRIM25, HEY1, FBXO7, BMP4, CTNNB1, TRIP4, ACO2, CDK9, DIMT1, GSK3A, KRAS, YAF2, UBE2M, TRAF6, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, CHD4, LARP7, RNF31, TNF, SPDL1, RIOK1, ESR2, HEXIM1, MEPCE, RNF123, PPT1, AGR2, RECQL4, DCPS, TXNIP, GPC1, REST, MYC, KRT17, EIF4B, SP3, RC3H2, PHB, USP14, NR2C2, PPP1CC, CTCF, ATXN3, VRK1, VRK3, HIST1H4A, APEX1, SNRNP70, ITFG1, HMGB1, BIRC3, NFX1, WWP2, ORF9b, SOX2, TRIM28, ARIH2, FANCD2, HCVgp1, ZC3H18, CDC42, MAPK14, nsp1, NEK4, DUX4, CIT, ANLN, AURKB, CHMP4C, KIF14, KIF20A, KIF23, PRC1, INS, Rnf183, BRD4, NINL, RBM45, CIC, Apc2, RBM39, FBP1, CREBBP, RAD1, UFL1, DDRGK1, LYN, ABCF3, ANKRD17, ASCC2, ASCC3, ATXN2, ATXN2L, BYSL, CAPRIN1, CCDC43, CDV3, CNOT1, CNOT2, CNOT3, CSDE1, CUEDC2, DDX3X, DHX57, EIF2A, EIF4E2, EIF4G2, FMR1, FUBP3, FXR2, G3BP1, G3BP2, GCN1L1, GIGYF2, GKAP1, GPBP1, GPBP1L1, HABP4, HDLBP, HELZ, IBTK, IGF2BP2, LARP1, LARP1B, LARP4, LARP4B, LSM14B, LTV1, ZAK, MKRN2, MYLK, NUFIP2, NUPL2, OTUD4, PABPC1, PABPC4, PRRC2A, PRRC2B, PRRC2C, PSMD1, PSMD4, PUM1, RBMS1, RIOK3, RNF10, SCAPER, SECISBP2, SEMA4A, SPATS2, SPATS2L, STRAP, TDRD3, TNRC6A, TNRC6B, TOP3B, TXNL1, UBAP2, UBAP2L, UPF1, USP10, USP16, WIPI1, YBX1, YBX3, YTHDF1, YTHDF2, YTHDF3, ZC3H7A, ZCCHC3, ZNF598, CEBPZ, EIF3C, EIF3G, EIF4H, FXR1, IGF2BP1, IGF2BP3, KRT6B, LSM12, PHF8, ZC3H15, ZC3HAV1, TRIM37, FZR1, PAGE4, NUDCD2, NAA40, HIST1H1B, YBX2, HIST1H1A, HIST1H2AM, LIN28A, SPRTN, BTF3, FBXW7, nsp15, CCNF, PDE4B, PSMD9,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPS20	chr8	56982015	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56982042	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56982084	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56982262	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
RPS20	chr8	56982283	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
RPS20	chr8	56982316	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS20	chr8	56982383	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS20	chr8	56982579	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56985413	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56985658	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPS20	chr8	56985661	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPS20	chr8	56985676	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS20	chr8	56985723	CAGA	C	Deletion	Uncertain_significance	not_provided	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
RPS20	chr8	56985738	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS20	chr8	56985751	C	CT	Duplication	Uncertain_significance	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS20	chr8	56985758	A	C	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS20	chr8	56985758	A	T	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS20	chr8	56985781	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS20	chr8	56985783	T	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS20	chr8	56985814	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS20	chr8	56985834	G	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56985838	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56986012	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56986074	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56986178	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56986248	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56986257	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS20	chr8	56986273	G	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS20	chr8	56986277	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS20	chr8	56986281	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS20	chr8	56986283	C	CT	Duplication	Uncertain_significance	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS20	chr8	56986287	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS20	chr8	56986290	ATTC	A	Deletion	Uncertain_significance	not_provided	SO:0001822\|inframe_deletion	SO:0001822\|inframe_deletion
RPS20	chr8	56986314	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS20	chr8	56986417	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
RPS20	chr8	56986531	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56986611	GC	AA	Indel	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56986614	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56986616	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56986635	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS20	chr8	56986641	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS20	chr8	56986679	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS20	chr8	56986696	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS20	chr8	56986696	G	GTA	Insertion	Uncertain_significance	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS20	chr8	56986701	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS20	chr8	56986711	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS20	chr8	56986721	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56986721	A	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56986729	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56986737	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56986808	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56986883	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56986931	C	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56986935	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS20	chr8	56986948	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS20	chr8	56987059	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS20	chr8	56987240	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant	SO:0001619\|non-coding_transcript_variant
RPS20	chr8	56987258	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant	SO:0001619\|non-coding_transcript_variant
RPS20	chr8	56987305	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant	SO:0001619\|non-coding_transcript_variant
RPS20	chr8	56987329	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant	SO:0001619\|non-coding_transcript_variant
RPS20	chr8	56987347	T	A	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant	SO:0001619\|non-coding_transcript_variant
RPS20	chr8	56987348	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant	SO:0001619\|non-coding_transcript_variant
RPS20	chr8	56987454	C	T	single_nucleotide_variant	Benign	not_provided

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS20	BRCA	chr8	56985781	56985781	C	G	Silent	p.T76	4
RPS20	KIRC	chr8	56986629	56986629	G	A	Silent	p.S31S	3
RPS20	HNSC	chr8	56985678	56985678	C	T	Missense_Mutation	p.E111K	2
RPS20	BLCA	chr8	56986287	56986287	G	A	Silent		2
RPS20	STAD	chr8	56986697	56986697	T	-	Frame_Shift_Del	p.T9fs	2
RPS20	UCEC	chr8	56982386	56982386	C	T	Missense_Mutation	p.E114K	2
RPS20	BLCA	chr8	56986683	56986683	C	T	Silent	p.P13P	2
RPS20	UCEC	chr8	56985755	56985755	T	C	Missense_Mutation	p.H85R	2
RPS20	UCEC	chr8	56985812	56985812	C	A	Missense_Mutation	p.R66I	2
RPS20	SARC	chr8	56986679	56986679	C	T	Missense_Mutation		2
RPS20	SARC	chr8	56986679	56986679	C	T	Missense_Mutation	p.V15M	2
RPS20	SKCM	chr8	56985769	56985769	G	A	Silent	p.F80F	2
RPS20	BLCA	chr8	56986648	56986648	G	T	Missense_Mutation		2
RPS20	SKCM	chr8	56985774	56985774	G	A	Missense_Mutation	p.R79C	2
RPS20	BLCA	chr8	56986298	56986298	C	G	Missense_Mutation		1
RPS20	SKCM	chr8	56986630	56986630	G	A	Missense_Mutation	p.S31F	1
RPS20	BLCA	chr8	56986267	56986267	C	G	Missense_Mutation		1
RPS20	KIRP	chr8	56986652	56986652	G	T	Missense_Mutation	p.L24I	1
RPS20	LUAD	chr8	56986254	56986254	C	G	Missense_Mutation	p.K59N	1
RPS20	BLCA	chr8	56986298	56986298	C	G	Missense_Mutation	p.E45Q	1
RPS20	LUSC	chr8	56985729	56985729	G	C	Missense_Mutation	p.P94A	1
RPS20	BLCA	chr8	56986656	56986656	G	A	Silent	p.I22I	1
RPS20	SARC	chr8	56985761	56985761	C	A	Missense_Mutation		1
RPS20	BLCA	chr8	56986287	56986287	G	A	Silent	p.L48L	1
RPS20	BLCA	chr8	56986267	56986267	C	G	Missense_Mutation	p.R55P	1
RPS20	GBM	chr8	56985787	56985787	A	T	Silent	p.S74S	1
RPS20	BLCA	chr8	56986683	56986683	C	T	Silent		1
RPS20	GBM	chr8	56985787	56985787	A	T	Silent		1
RPS20	SKCM	chr8	56985746	56985746	A	G	Missense_Mutation	p.L88P	1

Copy number variation (CNV) of RPS20
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS20
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
100377	N/A	AA531105	AKAP13	chr15	86109878	+	RPS20	chr8	56985613	+
100377	N/A	AV697694	BICD1	chr12	32325998	+	RPS20	chr8	56985613	+
100377	N/A	BF205135	C4orf45	chr4	159928246	-	RPS20	chr8	56987051	-
100377	N/A	AA420718	CABLES1	chr18	20808705	-	RPS20	chr8	56985613	+
100377	N/A	AA579295	CABLES1	chr18	20808709	-	RPS20	chr8	56985613	+
100377	N/A	AA164849	CASC16	chr16	52633713	+	RPS20	chr8	56985613	+
100377	N/A	AW605913	DDX46	chr5	134131676	-	RPS20	chr8	56981882	+
100377	STAD	TCGA-BR-8676-01A	EEF1A1	chr6	74227517	-	RPS20	chr8	56985781	-
100377	N/A	FN176424	FGF12	chr3	192111237	-	RPS20	chr8	56987068	-
100377	N/A	BM818077	HSPA9	chr5	137902738	-	RPS20	chr8	56987059	-
100377	N/A	N68015	LMO7	chr13	76339590	+	RPS20	chr8	56985613	+
100377	OV	TCGA-13-0913-02A	MYL6	chr12	56553842	+	RPS20	chr8	56986711	-
100377	N/A	EC557883	NCOA7	chr6	126228085	-	RPS20	chr8	56987029	-
100377	N/A	EC519648	NDUFB4	chr3	120321123	-	RPS20	chr8	56985670	-
100377	N/A	AA079014	NR2F2	chr15	96872312	+	RPS20	chr8	56985613	+
100377	N/A	BI493607	PELI2	chr14	56616339	+	RPS20	chr8	56985613	+
100377	N/A	AV692320	RBM39	chr20	34327887	-	RPS20	chr8	56985693	+
92035	N/A	AW020012	RPS20	chr8	56985613	-	ANK2	chr4	114272619	+
98708	N/A	BP226557	RPS20	chr8	56985613	-	CCNY	chr10	35561229	-
77592	N/A	BP428696	RPS20	chr8	56986958	-	CFD	chr19	861721	+
77592	N/A	BP225876	RPS20	chr8	56985613	-	DSN1	chr20	35393653	+
92779	STAD	TCGA-BR-A4QI-01A	RPS20	chr8	56986625	-	ENC1	chr5	73931532	-
77592	N/A	BI497390	RPS20	chr8	56985613	-	FRMPD3	chrX	106781766	+
77592	N/A	BG575217	RPS20	chr8	56985613	-	GTSCR1	chr18	68317616	-
101920	N/A	AW022948	RPS20	chr8	56985613	-	HSF2BP	chr21	44977890	+
96843	OV	TCGA-13-1499-01A	RPS20	chr8	56985613	-	IGF2	chr11	2153805	-
96843	OV	TCGA-13-1499-01A	RPS20	chr8	56985617	-	IGF2	chr11	2153823	-
95445	N/A	BM842093	RPS20	chr8	56986306	-	JOSD2	chr19	51009492	-
92754	LUSC	TCGA-66-2756-01A	RPS20	chr8	56985737	-	LYN	chr8	56926147	+
103191	N/A	AW020428	RPS20	chr8	56985613	-	NR2F2	chr15	96872312	-
94317	N/A	BP226358	RPS20	chr8	56985613	-	NSMCE2	chr8	126340413	-
98486	N/A	BP228372	RPS20	chr8	56985613	-	NXN	chr17	743033	+
92573	N/A	BP226273	RPS20	chr8	56985613	-	PICALM	chr11	85775695	+
78626	N/A	AI869081	RPS20	chr8	56985104	-	PLTP	chr20	44527405	+
101084	STAD	TCGA-BR-6455	RPS20	chr8	56986618	-	POLR2I	chr19	36605615	-
102937	HNSC	TCGA-CR-6467	RPS20	chr8	56986618	-	POMT2	chr14	77750216	-
100319	N/A	BP226453	RPS20	chr8	56985613	-	PTPRS	chr19	5172213	+
85136	N/A	BM015017	RPS20	chr8	56985613	-	RBL1	chr20	35693028	-
86058	STAD	TCGA-R5-A7ZE-01B	RPS20	chr8	56985618	-	SPRR1B	chr1	153003686	+
100599	N/A	AW021638	RPS20	chr8	56985613	-	SUOX	chr12	56389807	-
77592	BRCA	TCGA-A8-A082-01A	RPS20	chr8	56986628	-	TMEM70	chr8	74894454	+
77592	LUAD	TCGA-49-4494-01A	RPS20	chr8	56986624	-	TMEM70	chr8	74894458	+
77592	N/A	BM051734	RPS20	chr8	56987061	+	TWF2	chr3	52263983	-
77592	N/A	BF246983	RPS20	chr8	56985621	-	ZNF396	chr18	32955249	+
100377	N/A	AA507775	RSF1	chr11	77524577	+	RPS20	chr8	56985613	+
100377	N/A	BI495225	SH3GL3	chr15	84192699	-	RPS20	chr8	56985616	+
100377	N/A	AA573021	SMG6	chr17	2075047	+	RPS20	chr8	56985613	+
100377	N/A	BI491008	TSHZ2	chr20	51605124	-	RPS20	chr8	56985616	+
100390	N/A	AA469342	ZBTB20	chr3	114445757	-	RPS20	chr8	56985614	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	RPS20	0.00842721555589171	0.24
LIHC	RPS20	0.0107605985829517	0.29
LGG	RPS20	0.0166340824479792	0.43

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
PRAD	RPS20	0.041068518819697	1
UCS	RPS20	0.016945870082003	0.56

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1112155	Hereditary non-polyposis colorectal cancer syndrome	2	CLINGEN
C1333990	Hereditary Nonpolyposis Colorectal Cancer	2	CLINGEN
C1333991	Hereditary Non-Polyposis Colon Cancer Type 2	2	CLINGEN
C2936783	Colorectal cancer, hereditary nonpolyposis, type 1	2	CLINGEN
C3896578	Familial Colorectal Cancer Type X	1	ORPHANET