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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS21 (NCBI Gene ID:6227)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS21
	Gene ID: 6227
	Gene Symbol	RPS21
	Gene ID	6227
	Gene Name	ribosomal protein S21
	Synonyms	HLDF\|S21
	Cytomap	20q13.33
	Type of Gene	protein-coding
	Description	40S ribosomal protein S218.2 kDa differentiation factorhuman leukemia differentiation factorsmall ribosomal subunit protein eS21
	Modification date	20200313
	UniProtAcc	P63220

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS21	GO:0002181	cytoplasmic translation	25957688

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS21	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS21[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS21	Down-regulation of RpS21, a putative translation initiation factor interacting with P40, produces viable minute imagos and larval lethality with overgrown hematopoietic organs and imaginal discs	10022917

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000343986	60962898	60962970	In-frame
ENST00000343986	60963364	60963420	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000343986	60962898	60962970	361	154	225	83	38	62

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P63220	38	62	1	83	Chain	ID=PRO_0000194730;Note=40S ribosomal protein S21
P63220	38	62	41	41	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:25114211;Dbxref=PMID:25114211

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUSC	RPS21	-3.86646295834554	0.000217448138016549
LUAD	RPS21	-2.06355209027984	0.00342681008979313
ESCA	RPS21	-3.39437219011366	0.009765625
KIRC	RPS21	-1.2222651512906	4.25761914751048e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
KIRC	RPS21	hsa-miR-193b-3p	98	-0.307619279454723	0.00600351635741679

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
BRCA	RPS21	0.063329346	0.003671319
GBM	RPS21	0.165645021	0.029612023

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS21 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	RPS21	PFDN5	0.810702876	1.48E-11
CHOL	Cell metabolism gene	RPS21	SNRPD2	0.887314691	4.76E-16
CHOL	CGC	RPS21	NACA	0.804738178	2.71E-11
CHOL	Epifactor	RPS21	FBL	0.867788962	1.21E-14
COAD	Cell metabolism gene	RPS21	PSMA7	0.811086448	3.77E-78
COAD	Cell metabolism gene	RPS21	AHCY	0.848442421	2.30E-92
COAD	IUPHAR	RPS21	AHCY	0.848442421	2.30E-92
DLBC	Cell metabolism gene	RPS21	PMPCA	0.800459061	8.60E-12
DLBC	Cell metabolism gene	RPS21	TIMM10	0.800712265	8.38E-12
DLBC	Cell metabolism gene	RPS21	COASY	0.801563327	7.67E-12
DLBC	Cell metabolism gene	RPS21	TOMM7	0.804402714	5.69E-12
DLBC	Cell metabolism gene	RPS21	SNRPB	0.806697842	4.45E-12
DLBC	Cell metabolism gene	RPS21	SNRPE	0.810703667	2.88E-12
DLBC	Cell metabolism gene	RPS21	ITPA	0.813193314	2.19E-12
DLBC	Cell metabolism gene	RPS21	MMAB	0.814460876	1.90E-12
DLBC	Cell metabolism gene	RPS21	PSMB7	0.815160664	1.75E-12
DLBC	Cell metabolism gene	RPS21	DGUOK	0.817891252	1.28E-12
DLBC	Cell metabolism gene	RPS21	GFER	0.819408262	1.08E-12
DLBC	Cell metabolism gene	RPS21	PSMC3	0.823765323	6.47E-13
DLBC	Cell metabolism gene	RPS21	IDH3B	0.826921773	4.42E-13
DLBC	Cell metabolism gene	RPS21	TIMM50	0.829005472	3.43E-13
DLBC	Cell metabolism gene	RPS21	PFDN4	0.829100134	3.39E-13
DLBC	Cell metabolism gene	RPS21	GEMIN7	0.829833561	3.10E-13
DLBC	Cell metabolism gene	RPS21	SNRPD3	0.83676447	1.29E-13
DLBC	Cell metabolism gene	RPS21	ATP5G1	0.837224778	1.21E-13
DLBC	Cell metabolism gene	RPS21	PSMD13	0.838460753	1.03E-13
DLBC	Cell metabolism gene	RPS21	PTDSS2	0.83984754	8.60E-14
DLBC	Cell metabolism gene	RPS21	PSMC5	0.841883178	6.56E-14
DLBC	Cell metabolism gene	RPS21	POLR2J	0.851188466	1.81E-14
DLBC	Cell metabolism gene	RPS21	TIMM13	0.855080391	1.03E-14
DLBC	Cell metabolism gene	RPS21	POLR2L	0.856062332	8.87E-15
DLBC	Cell metabolism gene	RPS21	PSMB3	0.867100966	1.60E-15
DLBC	Cell metabolism gene	RPS21	TOMM22	0.868433459	1.29E-15
DLBC	Cell metabolism gene	RPS21	TIMM9	0.883561744	9.21E-17
DLBC	Cell metabolism gene	RPS21	POLR2I	0.886623497	5.16E-17
DLBC	Cell metabolism gene	RPS21	PFDN5	0.89686674	6.55E-18
DLBC	Cell metabolism gene	RPS21	POLR2F	0.898201532	4.93E-18
DLBC	Cell metabolism gene	RPS21	NME2	0.911043339	2.55E-19
DLBC	Cell metabolism gene	RPS21	FAU	0.923907153	8.09E-21
DLBC	Cell metabolism gene	RPS21	SNRPD2	0.928462945	2.06E-21
DLBC	CGC	RPS21	HRAS	0.813234646	2.18E-12
DLBC	CGC	RPS21	COX6C	0.817196561	1.39E-12
DLBC	CGC	RPS21	U2AF1	0.829666099	3.16E-13
DLBC	CGC	RPS21	NACA	0.856010814	8.94E-15
DLBC	Epifactor	RPS21	PRPF31	0.806838293	4.39E-12
DLBC	Epifactor	RPS21	ZNHIT1	0.810726795	2.87E-12
DLBC	Epifactor	RPS21	TAF10	0.812491644	2.36E-12
DLBC	Epifactor	RPS21	MBD3	0.815444919	1.70E-12
DLBC	Epifactor	RPS21	DMAP1	0.823213472	6.90E-13
DLBC	Epifactor	RPS21	BRMS1	0.829165538	3.36E-13
DLBC	Epifactor	RPS21	FBL	0.89823427	4.89E-18
DLBC	IUPHAR	RPS21	SIRT3	0.805837179	4.88E-12
DLBC	IUPHAR	RPS21	MMP24	0.811899611	2.52E-12
DLBC	IUPHAR	RPS21	HRAS	0.813234646	2.18E-12
DLBC	TF	RPS21	THAP3	0.802029945	7.30E-12
DLBC	TF	RPS21	MBD3	0.815444919	1.70E-12
DLBC	TF	RPS21	THAP7	0.824182112	6.15E-13
DLBC	TF	RPS21	ZNF444	0.83600529	1.42E-13
DLBC	TF	RPS21	THAP4	0.841203023	7.18E-14
DLBC	TF	RPS21	NME2	0.911043339	2.55E-19
DLBC	TSG	RPS21	SIRT3	0.805837179	4.88E-12
DLBC	TSG	RPS21	TSSC4	0.815984098	1.60E-12
DLBC	TSG	RPS21	BRMS1	0.829165538	3.36E-13
DLBC	TSG	RPS21	PHB	0.83013562	2.98E-13
DLBC	TSG	RPS21	GNB2L1	0.861162889	4.10E-15
DLBC	TSG	RPS21	PARK7	0.874315391	4.82E-16
DLBC	TSG	RPS21	GADD45GIP1	0.893940288	1.21E-17
GBM	Cell metabolism gene	RPS21	PSMB4	0.801704933	7.68E-40
GBM	Cell metabolism gene	RPS21	SNRPG	0.811015809	1.97E-41
GBM	Cell metabolism gene	RPS21	PFDN5	0.823653484	9.78E-44
GBM	Cell metabolism gene	RPS21	SNRPD2	0.834049785	8.95E-46
GBM	Cell metabolism gene	RPS21	PSMA7	0.882206548	1.71E-57
GBM	Cell metabolism gene	RPS21	FAU	0.889325942	1.17E-59
HNSC	Cell metabolism gene	RPS21	SNRPD2	0.805486497	2.90E-130
KIRP	Cell metabolism gene	RPS21	SNRPD2	0.840043912	2.95E-87
LGG	Cell metabolism gene	RPS21	PFDN5	0.803252772	6.70E-121
LGG	Cell metabolism gene	RPS21	FAU	0.900575729	3.54E-193
LIHC	Cell metabolism gene	RPS21	SNRPD2	0.813581733	3.46E-101
LIHC	Epifactor	RPS21	FBL	0.854898003	4.69E-122
MESO	Cell metabolism gene	RPS21	FAU	0.835710102	7.71E-24
PAAD	Cell metabolism gene	RPS21	FAU	0.826653131	4.53E-47
PRAD	Cell metabolism gene	RPS21	ZNRD1	0.808600148	2.44E-128
PRAD	Cell metabolism gene	RPS21	SNRPE	0.809028188	1.41E-128
PRAD	Cell metabolism gene	RPS21	TIMM13	0.812678937	1.23E-130
PRAD	Cell metabolism gene	RPS21	POLR2F	0.828027027	8.19E-140
PRAD	Cell metabolism gene	RPS21	POLR2I	0.837105542	1.11E-145
PRAD	Cell metabolism gene	RPS21	PSMB7	0.84186375	6.64E-149
PRAD	Cell metabolism gene	RPS21	TIMM9	0.844183512	1.63E-150
PRAD	Cell metabolism gene	RPS21	NME2	0.847261743	1.08E-152
PRAD	Cell metabolism gene	RPS21	FAU	0.865113924	2.39E-166
PRAD	Cell metabolism gene	RPS21	TOMM7	0.866457259	1.88E-167
PRAD	Cell metabolism gene	RPS21	SNRPD2	0.889745509	8.59E-189
PRAD	CGC	RPS21	NACA	0.809443675	8.27E-129
PRAD	Epifactor	RPS21	FBL	0.894650304	6.68E-194
PRAD	TF	RPS21	ZNF524	0.807115785	1.62E-127
PRAD	TF	RPS21	ZNF581	0.80812971	4.46E-128
PRAD	TF	RPS21	NME2	0.847261743	1.08E-152
PRAD	TSG	RPS21	GAS5	0.811295135	7.52E-130
PRAD	TSG	RPS21	GNB2L1	0.83868438	9.70E-147
TGCT	Cell metabolism gene	RPS21	TIMM13	0.804583249	1.11E-36
TGCT	Cell metabolism gene	RPS21	SNRPD2	0.831085176	4.42E-41
THCA	Cell metabolism gene	RPS21	PFDN5	0.818427284	2.84E-139
THCA	Cell metabolism gene	RPS21	TOMM7	0.839272984	5.74E-153
THCA	Cell metabolism gene	RPS21	SNRPD2	0.851823076	3.40E-162
THCA	Cell metabolism gene	RPS21	FAU	0.85588251	2.30E-165
THCA	Epifactor	RPS21	FBL	0.812216843	1.57E-135
THYM	Cell metabolism gene	RPS21	GALK1	0.800640933	1.82E-28
THYM	Cell metabolism gene	RPS21	FDPS	0.800918642	1.69E-28
THYM	Cell metabolism gene	RPS21	LSM5	0.802671161	1.05E-28
THYM	Cell metabolism gene	RPS21	IDH3B	0.803207167	9.08E-29
THYM	Cell metabolism gene	RPS21	IDH3G	0.804664989	6.09E-29
THYM	Cell metabolism gene	RPS21	PSMB4	0.805250418	5.18E-29
THYM	Cell metabolism gene	RPS21	PYCRL	0.805989992	4.22E-29
THYM	Cell metabolism gene	RPS21	GSTP1	0.806755275	3.41E-29
THYM	Cell metabolism gene	RPS21	PAFAH1B3	0.809241404	1.70E-29
THYM	Cell metabolism gene	RPS21	SNRPD3	0.812258836	7.19E-30
THYM	Cell metabolism gene	RPS21	GFER	0.812326767	7.05E-30
THYM	Cell metabolism gene	RPS21	UCKL1	0.812373916	6.96E-30
THYM	Cell metabolism gene	RPS21	PCYT2	0.813542443	4.96E-30
THYM	Cell metabolism gene	RPS21	TSTA3	0.813919877	4.45E-30
THYM	Cell metabolism gene	RPS21	SSR4	0.814013637	4.33E-30
THYM	Cell metabolism gene	RPS21	PSMB1	0.814370339	3.90E-30
THYM	Cell metabolism gene	RPS21	SNRPD1	0.816529651	2.07E-30
THYM	Cell metabolism gene	RPS21	FPGS	0.816535115	2.07E-30
THYM	Cell metabolism gene	RPS21	LSM3	0.816818601	1.90E-30
THYM	Cell metabolism gene	RPS21	SMPD2	0.817688548	1.47E-30
THYM	Cell metabolism gene	RPS21	POLR3K	0.817857503	1.40E-30
THYM	Cell metabolism gene	RPS21	MMAB	0.82112614	5.23E-31
THYM	Cell metabolism gene	RPS21	UROS	0.826836586	8.95E-32
THYM	Cell metabolism gene	RPS21	PSMB10	0.82688688	8.81E-32
THYM	Cell metabolism gene	RPS21	PSMC1	0.827005661	8.48E-32
THYM	Cell metabolism gene	RPS21	SNRPB	0.831265832	2.17E-32
THYM	Cell metabolism gene	RPS21	NME1	0.831379211	2.10E-32
THYM	Cell metabolism gene	RPS21	MIF	0.832407265	1.50E-32
THYM	Cell metabolism gene	RPS21	TBCB	0.832500385	1.46E-32
THYM	Cell metabolism gene	RPS21	LCMT1	0.83418402	8.37E-33
THYM	Cell metabolism gene	RPS21	IMPDH2	0.834751776	6.94E-33
THYM	Cell metabolism gene	RPS21	TALDO1	0.835238034	5.90E-33
THYM	Cell metabolism gene	RPS21	HSD17B10	0.836067313	4.48E-33
THYM	Cell metabolism gene	RPS21	HMOX2	0.83760323	2.67E-33
THYM	Cell metabolism gene	RPS21	DOHH	0.838102306	2.26E-33
THYM	Cell metabolism gene	RPS21	POLE4	0.838254428	2.14E-33
THYM	Cell metabolism gene	RPS21	PGP	0.838819807	1.77E-33
THYM	Cell metabolism gene	RPS21	NME2	0.839115701	1.60E-33
THYM	Cell metabolism gene	RPS21	DGUOK	0.841179306	7.86E-34
THYM	Cell metabolism gene	RPS21	PSME2	0.841255071	7.65E-34
THYM	Cell metabolism gene	RPS21	PTGES2	0.841475188	7.09E-34
THYM	Cell metabolism gene	RPS21	POLR2J	0.841518051	6.99E-34
THYM	Cell metabolism gene	RPS21	SEC61G	0.843838657	3.10E-34
THYM	Cell metabolism gene	RPS21	LSM2	0.844222454	2.71E-34
THYM	Cell metabolism gene	RPS21	DPM3	0.846261745	1.31E-34
THYM	Cell metabolism gene	RPS21	PHKG2	0.846485666	1.21E-34
THYM	Cell metabolism gene	RPS21	OAZ1	0.847716088	7.75E-35
THYM	Cell metabolism gene	RPS21	LSM4	0.848428591	5.98E-35
THYM	Cell metabolism gene	RPS21	WBSCR22	0.850766273	2.53E-35
THYM	Cell metabolism gene	RPS21	POLD4	0.850868647	2.44E-35
THYM	Cell metabolism gene	RPS21	NOP56	0.851523047	1.91E-35
THYM	Cell metabolism gene	RPS21	MVD	0.853008346	1.09E-35
THYM	Cell metabolism gene	RPS21	DTYMK	0.857132718	2.26E-36
THYM	Cell metabolism gene	RPS21	TIMM17B	0.857532685	1.93E-36
THYM	Cell metabolism gene	RPS21	ATP5G1	0.857981307	1.62E-36
THYM	Cell metabolism gene	RPS21	PSMD13	0.858021435	1.60E-36
THYM	Cell metabolism gene	RPS21	POLR2F	0.858765496	1.19E-36
THYM	Cell metabolism gene	RPS21	SRM	0.85940159	9.27E-37
THYM	Cell metabolism gene	RPS21	PSMC5	0.861482734	4.04E-37
THYM	Cell metabolism gene	RPS21	PSME1	0.862054088	3.21E-37
THYM	Cell metabolism gene	RPS21	DPM2	0.864356562	1.26E-37
THYM	Cell metabolism gene	RPS21	TOMM40	0.865286743	8.56E-38
THYM	Cell metabolism gene	RPS21	ALG3	0.866109424	6.08E-38
THYM	Cell metabolism gene	RPS21	SNRPE	0.868418929	2.30E-38
THYM	Cell metabolism gene	RPS21	GMPPA	0.869180281	1.66E-38
THYM	Cell metabolism gene	RPS21	GEMIN6	0.869542007	1.42E-38
THYM	Cell metabolism gene	RPS21	POLD2	0.869999979	1.17E-38
THYM	Cell metabolism gene	RPS21	GUK1	0.870227658	1.06E-38
THYM	Cell metabolism gene	RPS21	TOMM22	0.871694579	5.61E-39
THYM	Cell metabolism gene	RPS21	PSMD4	0.87453771	1.60E-39
THYM	Cell metabolism gene	RPS21	HMBS	0.876952627	5.36E-40
THYM	Cell metabolism gene	RPS21	MTX1	0.877373164	4.42E-40
THYM	Cell metabolism gene	RPS21	PSMC3	0.877430647	4.30E-40
THYM	Cell metabolism gene	RPS21	APRT	0.878066714	3.21E-40
THYM	Cell metabolism gene	RPS21	TIMM10	0.883362007	2.63E-41
THYM	Cell metabolism gene	RPS21	PMPCA	0.88434508	1.63E-41
THYM	Cell metabolism gene	RPS21	ITPA	0.885024609	1.17E-41
THYM	Cell metabolism gene	RPS21	PGLS	0.886600877	5.37E-42
THYM	Cell metabolism gene	RPS21	EXOSC5	0.886608156	5.35E-42
THYM	Cell metabolism gene	RPS21	PFDN5	0.88744958	3.51E-42
THYM	Cell metabolism gene	RPS21	NANS	0.887610484	3.24E-42
THYM	Cell metabolism gene	RPS21	POLR2I	0.889890265	1.02E-42
THYM	Cell metabolism gene	RPS21	GEMIN7	0.893574067	1.48E-43
THYM	Cell metabolism gene	RPS21	SSR2	0.89455243	8.74E-44
THYM	Cell metabolism gene	RPS21	EBP	0.895527059	5.16E-44
THYM	Cell metabolism gene	RPS21	PSMB7	0.901284094	2.05E-45
THYM	Cell metabolism gene	RPS21	FAU	0.906872918	7.36E-47
THYM	Cell metabolism gene	RPS21	PSMB3	0.909389666	1.54E-47
THYM	Cell metabolism gene	RPS21	TIMM50	0.911516543	3.94E-48
THYM	Cell metabolism gene	RPS21	ACOT8	0.912811251	1.69E-48
THYM	Cell metabolism gene	RPS21	POLR2H	0.91541548	2.97E-49
THYM	Cell metabolism gene	RPS21	EXOSC4	0.916029838	1.95E-49
THYM	Cell metabolism gene	RPS21	TIMM13	0.921524489	3.97E-51
THYM	Cell metabolism gene	RPS21	SLC27A5	0.922826351	1.51E-51
THYM	Cell metabolism gene	RPS21	TIMM8B	0.925783708	1.59E-52
THYM	Cell metabolism gene	RPS21	SNRPD2	0.938475797	3.01E-57
THYM	CGC	RPS21	MGMT	0.806267346	3.91E-29
THYM	CGC	RPS21	COX6C	0.813453019	5.09E-30
THYM	CGC	RPS21	ASPSCR1	0.828599079	5.12E-32
THYM	CGC	RPS21	RBM10	0.8486026	5.61E-35
THYM	CGC	RPS21	TFPT	0.861910571	3.40E-37
THYM	CGC	RPS21	SDHAF2	0.886135105	6.77E-42
THYM	Epifactor	RPS21	PPM1G	0.810807637	1.09E-29
THYM	Epifactor	RPS21	ZGPAT	0.823191956	2.78E-31
THYM	Epifactor	RPS21	CCDC101	0.823847523	2.27E-31
THYM	Epifactor	RPS21	MBD3	0.832490687	1.46E-32
THYM	Epifactor	RPS21	CDK5	0.83388344	9.24E-33
THYM	Epifactor	RPS21	INO80E	0.840160299	1.12E-33
THYM	Epifactor	RPS21	C17orf49	0.846513881	1.20E-34
THYM	Epifactor	RPS21	NOC2L	0.852034133	1.58E-35
THYM	Epifactor	RPS21	RUVBL2	0.852919625	1.13E-35
THYM	Epifactor	RPS21	PRMT1	0.85348039	9.16E-36
THYM	Epifactor	RPS21	LAS1L	0.861682326	3.73E-37
THYM	Epifactor	RPS21	TFPT	0.861910571	3.40E-37
THYM	Epifactor	RPS21	PPP4C	0.863956267	1.48E-37
THYM	Epifactor	RPS21	ZNHIT1	0.869718805	1.32E-38
THYM	Epifactor	RPS21	RRP8	0.879332257	1.79E-40
THYM	Epifactor	RPS21	EXOSC5	0.886608156	5.35E-42
THYM	Epifactor	RPS21	PRPF31	0.888130764	2.49E-42
THYM	Epifactor	RPS21	TAF10	0.889599642	1.18E-42
THYM	Epifactor	RPS21	SIRT6	0.897075137	2.21E-44
THYM	Epifactor	RPS21	EXOSC4	0.916029838	1.95E-49
THYM	Epifactor	RPS21	BRMS1	0.918475334	3.57E-50
THYM	Epifactor	RPS21	FBL	0.926828063	7.00E-53
THYM	IUPHAR	RPS21	FDPS	0.800918642	1.69E-28
THYM	IUPHAR	RPS21	FKBP1A	0.808821107	1.91E-29
THYM	IUPHAR	RPS21	PPIA	0.808965958	1.84E-29
THYM	IUPHAR	RPS21	PSMB1	0.814370339	3.90E-30
THYM	IUPHAR	RPS21	MFSD2B	0.814777073	3.46E-30
THYM	IUPHAR	RPS21	SMPD2	0.817688548	1.47E-30
THYM	IUPHAR	RPS21	ECE2	0.821207072	5.10E-31
THYM	IUPHAR	RPS21	ATP6V0B	0.832800607	1.32E-32
THYM	IUPHAR	RPS21	CDK5	0.83388344	9.24E-33
THYM	IUPHAR	RPS21	IMPDH2	0.834751776	6.94E-33
THYM	IUPHAR	RPS21	HMOX2	0.83760323	2.67E-33
THYM	IUPHAR	RPS21	PTGES2	0.841475188	7.09E-34
THYM	IUPHAR	RPS21	PHKG2	0.846485666	1.21E-34
THYM	IUPHAR	RPS21	MVD	0.853008346	1.09E-35
THYM	IUPHAR	RPS21	PRMT1	0.85348039	9.16E-36
THYM	IUPHAR	RPS21	EGLN2	0.853664662	8.54E-36
THYM	IUPHAR	RPS21	SIRT6	0.897075137	2.21E-44
THYM	IUPHAR	RPS21	SLC27A5	0.922826351	1.51E-51
THYM	Kinase	RPS21	ADCK4	0.820391149	6.54E-31
THYM	Kinase	RPS21	CDK5	0.83388344	9.24E-33
THYM	Kinase	RPS21	PHKG2	0.846485666	1.21E-34
THYM	TF	RPS21	DRAP1	0.803892675	7.53E-29
THYM	TF	RPS21	ZNF32	0.809369506	1.64E-29
THYM	TF	RPS21	ZNF524	0.810721905	1.12E-29
THYM	TF	RPS21	THAP7	0.811061492	1.01E-29
THYM	TF	RPS21	ZNF668	0.814804319	3.44E-30
THYM	TF	RPS21	ZGPAT	0.823191956	2.78E-31
THYM	TF	RPS21	ZNF428	0.823700316	2.38E-31
THYM	TF	RPS21	THAP3	0.824834003	1.67E-31
THYM	TF	RPS21	ZNF511	0.825123459	1.53E-31
THYM	TF	RPS21	ETV2	0.827568843	7.10E-32
THYM	TF	RPS21	RBCK1	0.831007714	2.36E-32
THYM	TF	RPS21	MBD3	0.832490687	1.46E-32
THYM	TF	RPS21	ZBTB48	0.83695069	3.33E-33
THYM	TF	RPS21	IRF3	0.838365421	2.06E-33
THYM	TF	RPS21	NME2	0.839115701	1.60E-33
THYM	TF	RPS21	REXO4	0.840548463	9.77E-34
THYM	TF	RPS21	USF1	0.853320992	9.73E-36
THYM	TF	RPS21	ZNF688	0.857768468	1.76E-36
THYM	TF	RPS21	ZNF787	0.87876521	2.33E-40
THYM	TF	RPS21	ZNF581	0.894890988	7.28E-44
THYM	TSG	RPS21	GSTP1	0.806755275	3.41E-29
THYM	TSG	RPS21	GABARAP	0.809091834	1.77E-29
THYM	TSG	RPS21	ST20	0.814137902	4.17E-30
THYM	TSG	RPS21	ZNF668	0.814804319	3.44E-30
THYM	TSG	RPS21	PHB	0.829541381	3.79E-32
THYM	TSG	RPS21	NME1	0.831379211	2.10E-32
THYM	TSG	RPS21	PARK7	0.83490113	6.60E-33
THYM	TSG	RPS21	ZBTB48	0.83695069	3.33E-33
THYM	TSG	RPS21	IRF3	0.838365421	2.06E-33
THYM	TSG	RPS21	GLTSCR2	0.839653936	1.33E-33
THYM	TSG	RPS21	GNB2L1	0.84708765	9.73E-35
THYM	TSG	RPS21	STUB1	0.858710297	1.22E-36
THYM	TSG	RPS21	NPRL2	0.863674158	1.66E-37
THYM	TSG	RPS21	GADD45GIP1	0.890981243	5.78E-43
THYM	TSG	RPS21	SIRT6	0.897075137	2.21E-44
THYM	TSG	RPS21	TSSC4	0.901002707	2.41E-45
THYM	TSG	RPS21	BRMS1	0.918475334	3.57E-50
UCS	Cell metabolism gene	RPS21	GALK1	0.800640933	1.82E-28
UCS	Cell metabolism gene	RPS21	FDPS	0.800918642	1.69E-28
UCS	Cell metabolism gene	RPS21	LSM5	0.802671161	1.05E-28
UCS	Cell metabolism gene	RPS21	IDH3B	0.803207167	9.08E-29
UCS	Cell metabolism gene	RPS21	IDH3G	0.804664989	6.09E-29
UCS	Cell metabolism gene	RPS21	PSMB4	0.805250418	5.18E-29
UCS	Cell metabolism gene	RPS21	PYCRL	0.805989992	4.22E-29
UCS	Cell metabolism gene	RPS21	GSTP1	0.806755275	3.41E-29
UCS	Cell metabolism gene	RPS21	PAFAH1B3	0.809241404	1.70E-29
UCS	Cell metabolism gene	RPS21	SNRPD3	0.812258836	7.19E-30
UCS	Cell metabolism gene	RPS21	GFER	0.812326767	7.05E-30
UCS	Cell metabolism gene	RPS21	UCKL1	0.812373916	6.96E-30
UCS	Cell metabolism gene	RPS21	PCYT2	0.813542443	4.96E-30
UCS	Cell metabolism gene	RPS21	TSTA3	0.813919877	4.45E-30
UCS	Cell metabolism gene	RPS21	SSR4	0.814013637	4.33E-30
UCS	Cell metabolism gene	RPS21	PSMB1	0.814370339	3.90E-30
UCS	Cell metabolism gene	RPS21	SNRPD1	0.816529651	2.07E-30
UCS	Cell metabolism gene	RPS21	FPGS	0.816535115	2.07E-30
UCS	Cell metabolism gene	RPS21	LSM3	0.816818601	1.90E-30
UCS	Cell metabolism gene	RPS21	SMPD2	0.817688548	1.47E-30
UCS	Cell metabolism gene	RPS21	POLR3K	0.817857503	1.40E-30
UCS	Cell metabolism gene	RPS21	MMAB	0.82112614	5.23E-31
UCS	Cell metabolism gene	RPS21	UROS	0.826836586	8.95E-32
UCS	Cell metabolism gene	RPS21	PSMB10	0.82688688	8.81E-32
UCS	Cell metabolism gene	RPS21	PSMC1	0.827005661	8.48E-32
UCS	Cell metabolism gene	RPS21	SNRPB	0.831265832	2.17E-32
UCS	Cell metabolism gene	RPS21	NME1	0.831379211	2.10E-32
UCS	Cell metabolism gene	RPS21	MIF	0.832407265	1.50E-32
UCS	Cell metabolism gene	RPS21	TBCB	0.832500385	1.46E-32
UCS	Cell metabolism gene	RPS21	LCMT1	0.83418402	8.37E-33
UCS	Cell metabolism gene	RPS21	IMPDH2	0.834751776	6.94E-33
UCS	Cell metabolism gene	RPS21	TALDO1	0.835238034	5.90E-33
UCS	Cell metabolism gene	RPS21	HSD17B10	0.836067313	4.48E-33
UCS	Cell metabolism gene	RPS21	HMOX2	0.83760323	2.67E-33
UCS	Cell metabolism gene	RPS21	DOHH	0.838102306	2.26E-33
UCS	Cell metabolism gene	RPS21	POLE4	0.838254428	2.14E-33
UCS	Cell metabolism gene	RPS21	PGP	0.838819807	1.77E-33
UCS	Cell metabolism gene	RPS21	NME2	0.839115701	1.60E-33
UCS	Cell metabolism gene	RPS21	DGUOK	0.841179306	7.86E-34
UCS	Cell metabolism gene	RPS21	PSME2	0.841255071	7.65E-34
UCS	Cell metabolism gene	RPS21	PTGES2	0.841475188	7.09E-34
UCS	Cell metabolism gene	RPS21	POLR2J	0.841518051	6.99E-34
UCS	Cell metabolism gene	RPS21	SEC61G	0.843838657	3.10E-34
UCS	Cell metabolism gene	RPS21	LSM2	0.844222454	2.71E-34
UCS	Cell metabolism gene	RPS21	DPM3	0.846261745	1.31E-34
UCS	Cell metabolism gene	RPS21	PHKG2	0.846485666	1.21E-34
UCS	Cell metabolism gene	RPS21	OAZ1	0.847716088	7.75E-35
UCS	Cell metabolism gene	RPS21	LSM4	0.848428591	5.98E-35
UCS	Cell metabolism gene	RPS21	WBSCR22	0.850766273	2.53E-35
UCS	Cell metabolism gene	RPS21	POLD4	0.850868647	2.44E-35
UCS	Cell metabolism gene	RPS21	NOP56	0.851523047	1.91E-35
UCS	Cell metabolism gene	RPS21	MVD	0.853008346	1.09E-35
UCS	Cell metabolism gene	RPS21	DTYMK	0.857132718	2.26E-36
UCS	Cell metabolism gene	RPS21	TIMM17B	0.857532685	1.93E-36
UCS	Cell metabolism gene	RPS21	ATP5G1	0.857981307	1.62E-36
UCS	Cell metabolism gene	RPS21	PSMD13	0.858021435	1.60E-36
UCS	Cell metabolism gene	RPS21	POLR2F	0.858765496	1.19E-36
UCS	Cell metabolism gene	RPS21	SRM	0.85940159	9.27E-37
UCS	Cell metabolism gene	RPS21	PSMC5	0.861482734	4.04E-37
UCS	Cell metabolism gene	RPS21	PSME1	0.862054088	3.21E-37
UCS	Cell metabolism gene	RPS21	DPM2	0.864356562	1.26E-37
UCS	Cell metabolism gene	RPS21	TOMM40	0.865286743	8.56E-38
UCS	Cell metabolism gene	RPS21	ALG3	0.866109424	6.08E-38
UCS	Cell metabolism gene	RPS21	SNRPE	0.868418929	2.30E-38
UCS	Cell metabolism gene	RPS21	GMPPA	0.869180281	1.66E-38
UCS	Cell metabolism gene	RPS21	GEMIN6	0.869542007	1.42E-38
UCS	Cell metabolism gene	RPS21	POLD2	0.869999979	1.17E-38
UCS	Cell metabolism gene	RPS21	GUK1	0.870227658	1.06E-38
UCS	Cell metabolism gene	RPS21	TOMM22	0.871694579	5.61E-39
UCS	Cell metabolism gene	RPS21	PSMD4	0.87453771	1.60E-39
UCS	Cell metabolism gene	RPS21	HMBS	0.876952627	5.36E-40
UCS	Cell metabolism gene	RPS21	MTX1	0.877373164	4.42E-40
UCS	Cell metabolism gene	RPS21	PSMC3	0.877430647	4.30E-40
UCS	Cell metabolism gene	RPS21	APRT	0.878066714	3.21E-40
UCS	Cell metabolism gene	RPS21	TIMM10	0.883362007	2.63E-41
UCS	Cell metabolism gene	RPS21	PMPCA	0.88434508	1.63E-41
UCS	Cell metabolism gene	RPS21	ITPA	0.885024609	1.17E-41
UCS	Cell metabolism gene	RPS21	PGLS	0.886600877	5.37E-42
UCS	Cell metabolism gene	RPS21	EXOSC5	0.886608156	5.35E-42
UCS	Cell metabolism gene	RPS21	PFDN5	0.88744958	3.51E-42
UCS	Cell metabolism gene	RPS21	NANS	0.887610484	3.24E-42
UCS	Cell metabolism gene	RPS21	POLR2I	0.889890265	1.02E-42
UCS	Cell metabolism gene	RPS21	GEMIN7	0.893574067	1.48E-43
UCS	Cell metabolism gene	RPS21	SSR2	0.89455243	8.74E-44
UCS	Cell metabolism gene	RPS21	EBP	0.895527059	5.16E-44
UCS	Cell metabolism gene	RPS21	PSMB7	0.901284094	2.05E-45
UCS	Cell metabolism gene	RPS21	FAU	0.906872918	7.36E-47
UCS	Cell metabolism gene	RPS21	PSMB3	0.909389666	1.54E-47
UCS	Cell metabolism gene	RPS21	TIMM50	0.911516543	3.94E-48
UCS	Cell metabolism gene	RPS21	ACOT8	0.912811251	1.69E-48
UCS	Cell metabolism gene	RPS21	POLR2H	0.91541548	2.97E-49
UCS	Cell metabolism gene	RPS21	EXOSC4	0.916029838	1.95E-49
UCS	Cell metabolism gene	RPS21	TIMM13	0.921524489	3.97E-51
UCS	Cell metabolism gene	RPS21	SLC27A5	0.922826351	1.51E-51
UCS	Cell metabolism gene	RPS21	TIMM8B	0.925783708	1.59E-52
UCS	Cell metabolism gene	RPS21	SNRPD2	0.938475797	3.01E-57
UCS	CGC	RPS21	MGMT	0.806267346	3.91E-29
UCS	CGC	RPS21	COX6C	0.813453019	5.09E-30
UCS	CGC	RPS21	ASPSCR1	0.828599079	5.12E-32
UCS	CGC	RPS21	RBM10	0.8486026	5.61E-35
UCS	CGC	RPS21	TFPT	0.861910571	3.40E-37
UCS	CGC	RPS21	SDHAF2	0.886135105	6.77E-42
UCS	Epifactor	RPS21	PPM1G	0.810807637	1.09E-29
UCS	Epifactor	RPS21	ZGPAT	0.823191956	2.78E-31
UCS	Epifactor	RPS21	CCDC101	0.823847523	2.27E-31
UCS	Epifactor	RPS21	MBD3	0.832490687	1.46E-32
UCS	Epifactor	RPS21	CDK5	0.83388344	9.24E-33
UCS	Epifactor	RPS21	INO80E	0.840160299	1.12E-33
UCS	Epifactor	RPS21	C17orf49	0.846513881	1.20E-34
UCS	Epifactor	RPS21	NOC2L	0.852034133	1.58E-35
UCS	Epifactor	RPS21	RUVBL2	0.852919625	1.13E-35
UCS	Epifactor	RPS21	PRMT1	0.85348039	9.16E-36
UCS	Epifactor	RPS21	LAS1L	0.861682326	3.73E-37
UCS	Epifactor	RPS21	TFPT	0.861910571	3.40E-37
UCS	Epifactor	RPS21	PPP4C	0.863956267	1.48E-37
UCS	Epifactor	RPS21	ZNHIT1	0.869718805	1.32E-38
UCS	Epifactor	RPS21	RRP8	0.879332257	1.79E-40
UCS	Epifactor	RPS21	EXOSC5	0.886608156	5.35E-42
UCS	Epifactor	RPS21	PRPF31	0.888130764	2.49E-42
UCS	Epifactor	RPS21	TAF10	0.889599642	1.18E-42
UCS	Epifactor	RPS21	SIRT6	0.897075137	2.21E-44
UCS	Epifactor	RPS21	EXOSC4	0.916029838	1.95E-49
UCS	Epifactor	RPS21	BRMS1	0.918475334	3.57E-50
UCS	Epifactor	RPS21	FBL	0.926828063	7.00E-53
UCS	IUPHAR	RPS21	FDPS	0.800918642	1.69E-28
UCS	IUPHAR	RPS21	FKBP1A	0.808821107	1.91E-29
UCS	IUPHAR	RPS21	PPIA	0.808965958	1.84E-29
UCS	IUPHAR	RPS21	PSMB1	0.814370339	3.90E-30
UCS	IUPHAR	RPS21	MFSD2B	0.814777073	3.46E-30
UCS	IUPHAR	RPS21	SMPD2	0.817688548	1.47E-30
UCS	IUPHAR	RPS21	ECE2	0.821207072	5.10E-31
UCS	IUPHAR	RPS21	ATP6V0B	0.832800607	1.32E-32
UCS	IUPHAR	RPS21	CDK5	0.83388344	9.24E-33
UCS	IUPHAR	RPS21	IMPDH2	0.834751776	6.94E-33
UCS	IUPHAR	RPS21	HMOX2	0.83760323	2.67E-33
UCS	IUPHAR	RPS21	PTGES2	0.841475188	7.09E-34
UCS	IUPHAR	RPS21	PHKG2	0.846485666	1.21E-34
UCS	IUPHAR	RPS21	MVD	0.853008346	1.09E-35
UCS	IUPHAR	RPS21	PRMT1	0.85348039	9.16E-36
UCS	IUPHAR	RPS21	EGLN2	0.853664662	8.54E-36
UCS	IUPHAR	RPS21	SIRT6	0.897075137	2.21E-44
UCS	IUPHAR	RPS21	SLC27A5	0.922826351	1.51E-51
UCS	Kinase	RPS21	ADCK4	0.820391149	6.54E-31
UCS	Kinase	RPS21	CDK5	0.83388344	9.24E-33
UCS	Kinase	RPS21	PHKG2	0.846485666	1.21E-34
UCS	TF	RPS21	DRAP1	0.803892675	7.53E-29
UCS	TF	RPS21	ZNF32	0.809369506	1.64E-29
UCS	TF	RPS21	ZNF524	0.810721905	1.12E-29
UCS	TF	RPS21	THAP7	0.811061492	1.01E-29
UCS	TF	RPS21	ZNF668	0.814804319	3.44E-30
UCS	TF	RPS21	ZGPAT	0.823191956	2.78E-31
UCS	TF	RPS21	ZNF428	0.823700316	2.38E-31
UCS	TF	RPS21	THAP3	0.824834003	1.67E-31
UCS	TF	RPS21	ZNF511	0.825123459	1.53E-31
UCS	TF	RPS21	ETV2	0.827568843	7.10E-32
UCS	TF	RPS21	RBCK1	0.831007714	2.36E-32
UCS	TF	RPS21	MBD3	0.832490687	1.46E-32
UCS	TF	RPS21	ZBTB48	0.83695069	3.33E-33
UCS	TF	RPS21	IRF3	0.838365421	2.06E-33
UCS	TF	RPS21	NME2	0.839115701	1.60E-33
UCS	TF	RPS21	REXO4	0.840548463	9.77E-34
UCS	TF	RPS21	USF1	0.853320992	9.73E-36
UCS	TF	RPS21	ZNF688	0.857768468	1.76E-36
UCS	TF	RPS21	ZNF787	0.87876521	2.33E-40
UCS	TF	RPS21	ZNF581	0.894890988	7.28E-44
UCS	TSG	RPS21	GSTP1	0.806755275	3.41E-29
UCS	TSG	RPS21	GABARAP	0.809091834	1.77E-29
UCS	TSG	RPS21	ST20	0.814137902	4.17E-30
UCS	TSG	RPS21	ZNF668	0.814804319	3.44E-30
UCS	TSG	RPS21	PHB	0.829541381	3.79E-32
UCS	TSG	RPS21	NME1	0.831379211	2.10E-32
UCS	TSG	RPS21	PARK7	0.83490113	6.60E-33
UCS	TSG	RPS21	ZBTB48	0.83695069	3.33E-33
UCS	TSG	RPS21	IRF3	0.838365421	2.06E-33
UCS	TSG	RPS21	GLTSCR2	0.839653936	1.33E-33
UCS	TSG	RPS21	GNB2L1	0.84708765	9.73E-35
UCS	TSG	RPS21	STUB1	0.858710297	1.22E-36
UCS	TSG	RPS21	NPRL2	0.863674158	1.66E-37
UCS	TSG	RPS21	GADD45GIP1	0.890981243	5.78E-43
UCS	TSG	RPS21	SIRT6	0.897075137	2.21E-44
UCS	TSG	RPS21	TSSC4	0.901002707	2.41E-45
UCS	TSG	RPS21	BRMS1	0.918475334	3.57E-50
UVM	Cell metabolism gene	RPS21	FAU	0.801470233	4.29E-19
UVM	TSG	RPS21	GLTSCR2	0.823147544	7.33E-21

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS21	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS21	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS21	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPS21	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS21	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS21	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS21	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS21	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS21	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS21	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS21	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPS21	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS21	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS21	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS21	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS21	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPS21	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS21	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPS21	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPS21	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS21	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS21	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS21	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS21	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPS21	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPS21	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS21	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS21	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS21

RPSA, CUL3, CDK2, CUL1, COPS5, CAND1, RPS4X, APP, RPL10A, RPL11, RPL13, RPL14, RPL18, RPL21, RPL23, RPL24, RPL31, RPL37A, RPL5, RPL6, RPL9, RPS15A, RPS16, RPS17, RPS23, RPS28, RPS3A, RPS6, RPS8, RPS26, RPS13, RPLP2, RPL7, RPL7A, RPS11, RPS25, RPL27, RPS24, RPS2, RPS12, RPS20, RPL12, RPS19, RPL10, RPS5, RPL19, RPL18A, RPL17, RPL23A, RPLP1, RPL4, RPS3, RPS29, RPL22, RPLP0, RPL15, RPS7, RPL30, UBA52, PABPC1, SLC25A5, HNRNPM, HNRNPA1, RPS27L, RPLP0P6, RPL10L, NUDCD2, ATP5I, RAD23B, NACA2, MRPS21, UBE2V2, CLNS1A, ANXA11, CCDC68, FN1, VCAM1, UBL4A, ITGA4, ADRM1, DYNLL1, GNB2L1, MTHFD1, PSMC1, PSMC2, PSMC6, PSMD11, PSMD1, PSMD3, PSMD8, RPS10, PSMD13, PSMD2, RPS18, RPS9, SYNCRIP, UCHL5, ZUFSP, ABL1, MAST3, CLCA2, RPL34, SFN, HIST1H3E, HNRNPU, NPM1, RAD21, THOC2, Eif3a, Eif3e, Osgep, Rpl35, Ufl1, Rrbp1, AR, CYLD, TES, TRIP4, UBE2M, PRPF8, AAR2, PIH1D1, EFTUD2, LARP7, ESR2, HEXIM1, MEPCE, RECQL4, RC3H1, RC3H2, PPP1CC, SNRNP70, ITFG1, WWP2, LRRK2, ZNF76, FHL5, PLEKHF2, ARIH2, DOK2, MAP2K3, PRKD1, RIPK1, ESR1, NEK4, CIT, ANLN, CHMP4C, ECT2, LRRC59, INS, CDC42, MAFB, Apc2, RIN3, DNAJC8, TP53BP1, TMA16, CSNK1E, PHF6, FXR2, PIP4K2A, TACO1, LYAR, LRPAP1, SLIT2, PIP4K2C, C9orf114, CA2, ATPIF1, CTTN, TMLHE, TCEB3, KARS, DDX58, UFL1, DDRGK1, ATG10, ATG3, FZR1, NAA40, NME2P1, RPSAP58, SLFN11, YTHDF3, EIF4ENIF1, nsp1, RCHY1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS21	BRCA	chr20	60963388	60963388	C	T	Missense_Mutation	p.S70F	3
RPS21	LIHC	chr20	60963367	60963367	T	G	Silent	p.G63G	2
RPS21	UCEC	chr20	60962906	60962906	A	C	Missense_Mutation	p.K41T	2
RPS21	CESC	chr20	60962962	60962962	C	T	Missense_Mutation		2
RPS21	UCEC	chr20	60963412	60963412	C	T	Missense_Mutation	p.R77C	2
RPS21	UCEC	chr20	60963564	60963564	T	C	Nonstop_Mutation	p.*97Q	2
RPS21	SKCM	chr20	60962424	60962424	C	T	Silent	p.D10D	2
RPS21	STAD	chr20	60962714	60962714	A	G	Missense_Mutation		2
RPS21	STAD	chr20	60962714	60962714	A	G	Missense_Mutation	p.Q33R	2
RPS21	UCEC	chr20	60963412	60963412	C	T	Silent		1
RPS21	CESC	chr20	60962391	60962391	C	G	Missense_Mutation		1
RPS21	LIHC	chr20	60962935	60962935	A	-	Frame_Shift_Del	p.K51fs	1
RPS21	CESC	chr20	60962391	60962391	C	G	RNA	NULL	1
RPS21	LUSC	chr20	60963410	60963410	A	T	Missense_Mutation		1
RPS21	CESC	chr20	60962962	60962962	C	T	Missense_Mutation	p.R60C	1
RPS21	CHOL	chr20	60962906	60962906	A	G	Missense_Mutation	p.K41R	1
RPS21	SKCM	chr20	60962668	60962668	T	A	Splice_Site	p.S18_splice	1
RPS21	ESCA	chr20	60963477	60963477	C	T	RNA	NULL	1
RPS21	SKCM	chr20	60963388	60963388	C	-	Frame_Shift_Del	p.L70fs	1
RPS21	GBM	chr20	60963374	60963374	G	C	Missense_Mutation		1
RPS21	HNSC	chr20	60962746	60962746	G	A	Missense_Mutation		1
RPS21	BLCA	chr20	60963011	60963011	C	T	Missense_Mutation		1
RPS21	KIRC	chr20	60963420	60963420	A	G	Missense_Mutation	p.K81R	1
RPS21	THYM	chr20	60962444	60962444	G	T	Missense_Mutation		1
RPS21	KIRC	chr20	60963416	60963419	TCAA	-	Frame_Shift_Del	p.79_80del	1
RPS21	UCEC	chr20	60963367	60963367	T	G	Silent		1
RPS21	BRCA	chr20	60963055	60963055	T	C	Nonstop_Mutation	p.*91Q	1
RPS21	LIHC	chr20	60962943	60962943	T	C	Silent		1

Copy number variation (CNV) of RPS21
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS21
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
75228	N/A	BC036946	ANKRD52	chr12	56635489	-	RPS21	chr20	60962379	+
75228	N/A	AA665328	APOBEC3A	chr22	39371744	-	RPS21	chr20	60963576	-
75228	N/A	AA654946	COG8	chr16	69367090	+	RPS21	chr20	60963576	-
75228	N/A	AA535764	GPATCH1	chr19	33579041	+	RPS21	chr20	60963576	-
75228	OV	TCGA-13-0919	HSF1	chr8	145515556	+	RPS21	chr20	60962376	+
75228	Non-Cancer	267N	LAMA5	chr20	60900371	-	RPS21	chr20	60962898	+
75228	N/A	EC564180	LIN28B	chr6	105412895	-	RPS21	chr20	60963573	-
75228	STAD	TCGA-CD-8525-01A	PIM3	chr22	50355016	+	RPS21	chr20	60962377	+
75228	N/A	EC461525	RANBP2	chr2	110423335	-	RPS21	chr20	60963571	-
75228	N/A	EC576784	RANBP2	chr2	110423335	-	RPS21	chr20	60963558	-
75228	N/A	BG222249	RNU4-2	chr12	120729581	-	RPS21	chr20	60962710	+
100566	N/A	BG059301	RPS21	chr20	60963576	+	APOBEC3A	chr22	39371744	+
102059	N/A	BP428656	RPS21	chr20	60963576	+	ARID5B	chr10	63661754	-
87925	N/A	CF123540	RPS21	chr20	60963576	+	C16orf96	chr16	4640863	+
79791	N/A	AV691334	RPS21	chr20	60963576	+	C4orf22	chr4	81811573	+
100410	N/A	GW492802	RPS21	chr20	60963575	+	CNKSR2	chrX	21439434	-
96058	N/A	CF122729	RPS21	chr20	60963578	+	CPD	chr17	28766455	-
100971	N/A	BI863835	RPS21	chr20	60962378	-	DENND1A	chr9	126499148	-
77629	N/A	AV698609	RPS21	chr20	60963576	+	EEF1G	chr11	62328965	+
100133	N/A	AX381387	RPS21	chr20	60963576	+	ERCC8	chr5	60233949	-
99835	READ	TCGA-AG-3728	RPS21	chr20	60962952	+	ETV5	chr3	185826703	-
89200	N/A	BG033493	RPS21	chr20	60963576	+	HELLS	chr10	96345465	-
101920	N/A	BI858932	RPS21	chr20	60963576	+	HSF2BP	chr21	44942765	-
89686	N/A	CF123815	RPS21	chr20	60963576	+	IFT140	chr16	1633630	-
78576	N/A	BU571134	RPS21	chr20	60963574	+	LINC00472	chr6	72100556	+
90430	N/A	BG029470	RPS21	chr20	60963576	+	MID1	chrX	10570284	-
96987	N/A	CS190729	RPS21	chr20	60963572	+	MITF	chr3	69904071	+
77629	N/A	AI275065	RPS21	chr20	60963482	-	PIAS3	chr1	145578714	+
101132	Non-Cancer	ERR315359	RPS21	chr20	60962730	+	PRKAR1B	chr7	647089	-
77629	N/A	BU571106	RPS21	chr20	60963575	+	PRKY	chrY	7235863	-
96928	N/A	BG032233	RPS21	chr20	60963576	+	PRMT3	chr11	20413228	-
77629	N/A	AV691666	RPS21	chr20	60963576	+	ROR2	chr9	94672160	-
77629	N/A	AV687773	RPS21	chr20	60963576	+	RP11-114J13.1	chr5	125567325	+
101134	Non-Cancer	TCGA-BH-A0E0-11A	RPS21	chr20	60962192	+	RPL3	chr22	39714529	-
94631	N/A	AV751221	RPS21	chr20	60963578	+	XIST	chrX	73069668	-
102316	COAD	TCGA-A6-2679-01A	RPS21	chr20	60962419	+	ZNF536	chr19	31039220	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPS21	0.0106022131809135	0.3
ACC	RPS21	0.0151312356663275	0.41

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	RPS21	0.042781331925646	1
LUSC	RPS21	0.0186823239346111	0.61
BRCA	RPS21	0.0183532970717132	0.61
PRAD	RPS21	0.0263138014529599	0.79
PAAD	RPS21	0.0188394700260049	0.61
SARC	RPS21	0.0369144412706358	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0024623	Malignant neoplasm of stomach	1	CTD_human
C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human