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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS26 (NCBI Gene ID:6231)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS26
	Gene ID: 6231
	Gene Symbol	RPS26
	Gene ID	6231
	Gene Name	ribosomal protein S26
	Synonyms	DBA10\|S26\|eS26
	Cytomap	12q13.2
	Type of Gene	protein-coding
	Description	40S ribosomal protein S26small ribosomal subunit protein eS26
	Modification date	20200313
	UniProtAcc	P62854

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS26	GO:0002181	cytoplasmic translation	25957688
Hgene	RPS26	GO:0033119	negative regulation of RNA splicing	15716004

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS26	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS26[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS26	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000552361	56436208	56436386	Frame-shift
ENST00000356464	56437146	56437277	Frame-shift
ENST00000552361	56437146	56437277	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	RPS26	-1.30179981165725	0.0163893452361939

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
BLCA	RPS26	1	2	0.0270198238301585	0.181889898989899	0.285787855088097	0.693700515020586	0.38410283187864

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS26 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type

Gene group

Translation factor

Correlated gene

Coefficient

Pvalue

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS26	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS26	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS26	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPS26	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS26	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS26	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS26	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS26	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS26	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS26	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS26	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPS26	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS26	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS26	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS26	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS26	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPS26	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS26	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPS26	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPS26	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS26	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS26	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS26	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS26	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPS26	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPS26	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS26	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS26	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS26

TSR2, MAGEB2, NELFCD, AGO4, NDRG1, SIRT7, APP, RPL15, RPL18A, RPL18, RPL19, RPL31, RPL37A, RPL3, RPL4, RPL6, RPL7A, RPL7, RPL9, RPLP2, RPS11, RPS13, RPS15A, RPS16, RPS19, RPS3A, RPS3, RPS4X, RPS8, RPL14, RPL10A, RPL23A, RPL8, RPL27, RPS12, RPL21, RPS6, RPS23, RPS2, RPS17, RPS24, RPL12, RPL5, RPL23, RPS20, RPS10, RPL24, RPSA, RPL11, RPS5, RPL10, RPLP1, RPLP0, RPL22, RPS15, RPS14, RPL30, RPS25, RPL17, RPL29, RPL32, RPS27A, RPS21, FAU, ILF3, NCL, DHX9, MOV10, ILF2, HNRNPU, HSP90AB1, EIF4A1, HNRNPM, TUFM, ACTA2, RPL10L, RPLP0P6, NENF, RHOT2, TMEM165, SLC25A1, CDH2, RPS10P5, ECE1, PRKCDBP, NDUFAF2, MRPS11, PPT2, ESR1, FN1, UBL4A, PAN2, MDM2, TP53, EP300, DYNC1I2, EIF3A, EIF3CL, EIF3K, PNO1, BYSL, DYNC1LI2, KIAA0368, PRUNE2, RPS18, RPS27, RPS29, RPS7, RPS9, SERBP1, WDR26, RPS28, SND1, TSR1, WIBG, CUL7, EED, RNF2, ARID4B, RPL13, RPL13A, RPL26, RPL26L1, RPL27A, RPL34, RPL35, RPL36, RPL38, RPL3L, VAPA, TMED2, PTEN, SRPK2, HIST1H3E, MCM2, CDH1, CYLD, TRIM25, FBXO7, PPP1CC, WDR77, MAP2K3, ACO2, APOE, BCL2L1, DIMT1, GSK3A, PCBP1, PPIE, CUL4B, PRPF8, PIH1D1, EFTUD2, REL, TNIP2, LARP7, TNF, HEXIM1, MEPCE, RNF123, RECQL4, REST, CDK9, RPS6KB2, METTL3, METTL14, PSME3, EIF4B, ACTC1, PHB, MAPT, NR2C2, CTCF, MECOM, VRK1, DYRK1A, MAB21L2, SNRNP70, Dppa3, ITFG1, BIRC3, TRIM28, CMTR1, SDCBP, OTX2, ARIH2, PLEKHA4, YAP1, TFCP2, WHSC1, FANCD2, HCVgp1, ZC3H18, MAP3K14, M, nsp4, nsp6, ORF3a, ORF7a, ORF8, CIT, ANLN, KIF14, KIF20A, KIF23, PRC1, INS, NDN, Rnf183, Apc2, RBM39, FBP1, MKRN1, BKRF1, PRDM16, SPOP, ISG15, PARK2, DDRGK1, TRIM37, FZR1, DDX39A, RRS1, ADARB1, NOTCH2, CD6, LIN28A, PRKRA, HIST1H1A, SPRTN, BTF3, FBXW7, Rbm14, SQSTM1, BRD3, BRD4, BRDT, BRD2,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPS26	chr12	56435412	G	A	single_nucleotide_variant	Benign	not_provided
RPS26	chr12	56435742	T	G	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_10	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS26	chr12	56435802	G	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_10	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS26	chr12	56435821	T	G	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_10	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS26	chr12	56435850	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS26	chr12	56435871	C	T	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_10	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS26	chr12	56435916	G	A	single_nucleotide_variant	Benign/Likely_benign	Diamond-Blackfan_anemia_10\|not_specified	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS26	chr12	56435918	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_10	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS26	chr12	56435920	C	G	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_10\|not_specified	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS26	chr12	56435920	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_10	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS26	chr12	56435924	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_10	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS26	chr12	56435926	C	T	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_10	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS26	chr12	56435929	C	G	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_10\|not_specified	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS26	chr12	56435942	G	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_10	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS26	chr12	56435948	A	G	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_10	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPS26	chr12	56435951	A	C	single_nucleotide_variant	Pathogenic	Bone_marrow_hypocellularity	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant
RPS26	chr12	56435951	A	G	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_10	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant
RPS26	chr12	56435951	A	T	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_10\|not_provided	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant
RPS26	chr12	56435952	T	G	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_10	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant	SO:0001582\|initiatior_codon_variant,SO:0001583\|missense_variant
RPS26	chr12	56435954	G	A	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_10	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RPS26	chr12	56435960	C	G	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_10	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS26	chr12	56435960	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_10	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS26	chr12	56435962	T	A	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_10	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS26	chr12	56435967	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_10	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS26	chr12	56436111	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS26	chr12	56436207	A	T	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_15_with_mandibulofacial_dysostosis\|Diamond-Blackfan_anemia_10	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
RPS26	chr12	56436210	CAAAG	C	Deletion	Pathogenic	Diamond-Blackfan_anemia_10	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS26	chr12	56436223	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS26	chr12	56436235	T	TG	Duplication	Pathogenic	Diamond-Blackfan_anemia_10	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS26	chr12	56436260	C	T	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_10	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS26	chr12	56436266	A	C	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_10	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS26	chr12	56436268	T	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS26	chr12	56436274	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_10	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS26	chr12	56436286	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_10	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS26	chr12	56436298	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Diamond-Blackfan_anemia_10\|not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS26	chr12	56436302	G	A	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_10	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS26	chr12	56436349	A	G	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_10	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS26	chr12	56436362	A	G	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_10	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS26	chr12	56436385	TG	T	Deletion	Pathogenic	Diamond-Blackfan_anemia_10	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RPS26	chr12	56436390	AGT	A	Deletion	Uncertain_significance	Diamond-Blackfan_anemia_10	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS26	chr12	56436472	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS26	chr12	56436917	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS26	chr12	56437118	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS26	chr12	56437161	A	T	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_10	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS26	chr12	56437184	C	G	single_nucleotide_variant	Pathogenic	not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS26	chr12	56437184	CTG	C	Microsatellite	Pathogenic/Likely_pathogenic	Diamond-Blackfan_anemia_10	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPS26	chr12	56437224	C	T	single_nucleotide_variant	Pathogenic	Diamond-Blackfan_anemia_15_with_mandibulofacial_dysostosis\|Diamond-Blackfan_anemia_10	SO:0001587\|nonsense	SO:0001587\|nonsense
RPS26	chr12	56437231	G	A	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_10	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS26	chr12	56437231	G	C	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_10	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPS26	chr12	56437235	A	G	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_10	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS26	chr12	56437256	C	T	single_nucleotide_variant	Likely_benign	Diamond-Blackfan_anemia_10	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS26	chr12	56437277	G	A	single_nucleotide_variant	Uncertain_significance	Diamond-Blackfan_anemia_10	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS26	chr12	56437279	T	A	single_nucleotide_variant	Likely_pathogenic	Anemia\|Pure_red-cell_aplasia	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
RPS26	chr12	56437304	G	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS26	chr12	56437305	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS26	chr12	56437917	T	A	single_nucleotide_variant	Benign	Diamond-Blackfan_anemia_10\|not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS26	chr12	56438129	C	CTT	Duplication	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
RPS26	chr12	56438154	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS26	ESCA	chr12	56436335	56436336	AT	-	Frame_Shift_Del	p.I44fs	2
RPS26	ESCA	chr12	56436329	56436329	C	T	Nonsense_Mutation	p.R42*	2
RPS26	SARC	chr12	56436288	56436288	G	T	Missense_Mutation	p.R28L	2
RPS26	SKCM	chr12	56437912	56437912	C	T	Missense_Mutation	p.P108S	2
RPS26	LUAD	chr12	56436228	56436228	A	G	Missense_Mutation	p.N8S	2
RPS26	LUSC	chr12	56436328	56436328	T	G	Missense_Mutation	p.I41M	1
RPS26	ESCA	chr12	56436335	56436336	AT	-	Frame_Shift_Del		1
RPS26	SARC	chr12	56436288	56436288	G	T	Missense_Mutation		1
RPS26	ESCA	chr12	56436335	56436336	AT	-	Frame_Shift_Del	p.43_44del	1
RPS26	ESCA	chr12	56436329	56436329	C	T	Nonsense_Mutation	p.R42X	1
RPS26	STAD	chr12	56437254	56437254	C	-	Frame_Shift_Del	p.T96fs	1
RPS26	GBM	chr12	56436346	56436346	C	T	Silent	p.A47A	1
RPS26	UCEC	chr12	56437168	56437168	A	G	Missense_Mutation	p.Y68C	1
RPS26	GBM	chr12	56436346	56436346	C	T	Silent		1
RPS26	HNSC	chr12	56436379	56436379	C	G	Silent		1
RPS26	HNSC	chr12	56436379	56436379	C	G	Silent	p.V58V	1
RPS26	BLCA	chr12	56436330	56436330	G	T	Missense_Mutation	p.R42L	1
RPS26	KIRC	chr12	56436231	56436231	G	A	Missense_Mutation	p.G9D	1
RPS26	CESC	chr12	56436361	56436361	C	T	Silent	p.D52D	1

Copy number variation (CNV) of RPS26
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS26
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Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
77714	N/A	BF216839	RPS26	chr12	56438003	+	GGACT	chr13	101192526	-
77714	N/A	BF688149	RPS26	chr12	56438004	+	GGACT	chr13	101192526	-
101849	N/A	DD229253	RPS26	chr12	56436214	-	HNRNPH3	chr10	70093614	-
77714	OV	TCGA-04-1341-01A	RPS26	chr12	56438001	+	ZRSR1	chr5	112228788	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BLCA	RPS26	0.0385098672640282	1
LIHC	RPS26	0.0398206229600524	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SKCM	RPS26	0.0344283446770085	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1260899	Anemia, Diamond-Blackfan	4	GENOMICS_ENGLAND
C2750080	Diamond-Blackfan Anemia 10	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
C0008925	Cleft Palate	1	GENOMICS_ENGLAND
C0024623	Malignant neoplasm of stomach	1	CTD_human
C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human