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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS27 (NCBI Gene ID:6232)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS27
	Gene ID: 6232
	Gene Symbol	RPS27
	Gene ID	6232
	Gene Name	ribosomal protein S27
	Synonyms	DBA17\|MPS-1\|MPS1\|S27
	Cytomap	1q21.3
	Type of Gene	protein-coding
	Description	40S ribosomal protein S27metallopan-stimulin 1metallopanstimulin 1small ribosomal subunit protein eS27
	Modification date	20200320
	UniProtAcc	P42677

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS27	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS27[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS27	Conservation of multifunctional ribosomal protein metallopanstimulin-1 (RPS27) through complex evolution demonstrates its key role in growth regulation in Archaea, eukaryotic cells, DNA repair, translation and viral replication	21518817

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000368567	153964041	153964152	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000368567	153964041	153964152	367	154	264	84	38	75

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P42677	38	75	2	84	Chain	ID=PRO_0000149051;Note=40S ribosomal protein S27
P42677	38	75	37	59	Zinc finger	Note=C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type

Translation factor

adj.pval

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
UCEC	RPS27	0.057714728	0.006821223

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS27 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
GBM	TF	RPS27	ZNF90	0.844940186	4.56E-48

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS27	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPS27	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPS27	RPS16	-1.35957043617517	0.00019507110118866
STAD	RPS27	RPS23	1.85076760664576	0.000364991836249828
COAD	RPS27	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS27	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS27	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS27	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS27	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS27	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS27	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS27	RPS16	-6.16322798156577	0.0115764821363307
LUSC	RPS27	RPS23	1.46751169891047	0.0174932185880974
BLCA	RPS27	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPS27	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPS27	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS27	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS27	RPL19	-2.14669889516666	0.044366810398747
UCEC	RPS27	RPS23	-2.03658159814007	0.046875
KIRC	RPS27	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS27	RPS12	-4.91239327478244	1.85340619742495e-09
KIRC	RPS27	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS27	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS27	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS27	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPS27	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRP	RPS27	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS27	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS27	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS27

APC, MDM2, ENOPH1, MARS, RTN4, C2orf44, HMP19, NACAD, PPBP, VHL, CUL3, CUL2, CDK2, CUL1, COPS5, CAND1, FN1, VCAM1, UBL4A, RL1, PAN2, TOM1, SKIL, ENTPD4, ACTN4, ACTN1, EIF3CL, HNRNPA0, HNRNPU, PNO1, PTBP1, RANBP9, RPL35, RPS13, RPS14, RPS15A, RPS26, BYSL, EIF3D, FAU, GNB2L1, RPL23A, RPS10, RPS12, RPS16, RPS18, RPS20, RPS23, RPS24, RPS27L, RPS28, RPS3A, RPS4X, RPS5, RPS7, RPS9, RPS3, RPS6, RPS8, SND1, TSR1, WIBG, ASB3, ZBTB1, AURKA, AURKB, TUBGCP4, TP53, TUBGCP3, BRCA1, ABCE1, RPL10A, RPL12, RPL18, RPL18A, RPL27, RPL27A, RPL30, RPL6, RPL7A, RPL8, RPL9, RPLP2, RPS19, RPS25, RPL10, RPL11, RPL13, RPL13A, RPL14, RPL15, RPL21, RPL22, RPL23, RPL24, RPL3, RPL31, RPL34, RPL35A, RPL36AL, RPL38, RPL4, RPL5, RPL7, RPLP0, RPS11, RPS15, RPS2, RPSA, PTEN, NPM1, NOP56, CNOT1, IBTK, Eif3a, Fbl, Eif3e, Rpl35, Srp72, Rrbp1, MCM2, ERBB3, ESRRB, CDC37, ZNF131, EGFR, POTEF, ATP7A, SRC, ERICH5, TUBA4A, PAG1, FUS, TUBB8, RAP1BL, PPP2R5E, PPP2R5D, TUBA1A, POLE4, ACTB, EEF1A1, TUBB3, NCL, CYLD, FOXA1, ZNF598, FBXO7, RIPK4, MAPK6, HSPA8, LARS, TGFB1, CDK9, CTNNB1, GSK3A, IGF1R, MTCH2, PIK3CA, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, CHD3, CHD4, RNF31, TNF, HEXIM1, MEPCE, LARP7, AGR2, ZBTB38, DCPS, KDM6B, Prkab1, METTL14, PSME3, RC3H1, RC3H2, ATG16L1, PHB, RBX1, TMEM41B, NR2C2, CTCF, ATXN3, VRK1, SNRNP70, ITFG1, BIRC3, STAU1, NFX1, WWP2, TEX101, PLEKHA4, ESR1, HCVgp1, ORF50, ZC3H18, CDC42, DUSP6, MAP3K14, RAB5A, M, nsp13, nsp14, nsp4, nsp5, nsp6, ORF3a, ORF7a, IMMP2L, NEK4, ANLN, CHMP4C, ECT2, MAD2L2, KIF20A, KIF23, PRC1, INS, E5b, C18orf8, Apc2, RIN3, PRDM11, PARK2, UFL1, DDRGK1, COIL, PDHA1, PEX3, POLR1E, POLR2C, NFKBIA, ATG3, FZR1, NAA40, ZBTB2, HKDC1, PRSS8, MROH1, CBWD1, TMPRSS5, NUBPL, FANCI, HEATR1, LTV1, HEATR6, HBD, TUBB, SPRTN, BTF3, FBXW7, MRPS18C, Cpsf6, Htatsf1, CCNF, TOLLIP, CALCOCO2,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPS27	chr1	153963583	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS27	chr1	153963650	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
RPS27	chr1	153963672	TC	T	Deletion	Pathogenic	Diamond-Blackfan_anemia_17	SO:0001589\|frameshift_variant,SO:0001623\|5_prime_UTR_variant	SO:0001589\|frameshift_variant,SO:0001623\|5_prime_UTR_variant
RPS27	chr1	153963808	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS27	chr1	153963995	A	AAG	Duplication	Benign	Diamond-Blackfan_anemia_17	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS27	chr1	153964067	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS27	chr1	153964396	C	CAA	Insertion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS27	chr1	153964837	G	GT	Duplication	Benign	not_provided

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS27	SKCM	chr1	153963240	153963240	T	G	Splice_Site	.	5
RPS27	BRCA	chr1	153963702	153963702	G	C	Missense_Mutation	p.E40Q	3
RPS27	READ	chr1	153964547	153964547	C	T	Missense_Mutation	p.S78F	3
RPS27	HNSC	chr1	153964115	153964115	C	G	Silent	p.L63L	2
RPS27	STAD	chr1	153963678	153963678	T	G	Missense_Mutation	p.F32V	2
RPS27	KIRC	chr1	153963625	153963625	A	C	Missense_Mutation	p.E14A	2
RPS27	UCEC	chr1	153964056	153964056	A	G	Missense_Mutation	p.T44A	2
RPS27	LUAD	chr1	153963616	153963616	C	T	Missense_Mutation	p.S11F	2
RPS27	SKCM	chr1	153963239	153963239	C	G	Splice_Site	.	1
RPS27	COAD	chr1	153963624	153963626	GAG	-	In_Frame_Del	p.13_14del	1
RPS27	SKCM	chr1	153963248	153963248	G	A	Translation_Start_Site		1
RPS27	LIHC	chr1	153963600	153963600	G	A	Missense_Mutation	p.D6N	1
RPS27	LIHC	chr1	153963723	153963723	G	-	Frame_Shift_Del	p.G47fs	1
RPS27	LIHC	chr1	153963690	153963690	A	-	Frame_Shift_Del	p.K36fs	1
RPS27	PAAD	chr1	153964128	153964128	G	T	Nonsense_Mutation	p.G68*	1
RPS27	BLCA	chr1	153964055	153964055	C	T	Silent		1
RPS27	BLCA	chr1	153964055	153964055	C	T	Silent	p.I43I	1

Copy number variation (CNV) of RPS27
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS27
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
99398	N/A	CF122513	RPS27	chr1	153964626	+	ADAM9	chr8	38871287	-
77785	COAD	TCGA-AA-3952-01A	RPS27	chr1	153963699	+	FAM159B	chr5	63986324	+
100425	N/A	BF337590	RPS27	chr1	153964626	+	PPP1R12B	chr1	202441264	-
83858	N/A	M31520	RPS27	chr1	153964127	-	RPS24	chr10	79793623	+
95461	N/A	BF218500	RPS27	chr1	153964621	+	TSPAN9	chr12	3321117	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
ACC	RPS27	2.3003872029235	0.83307745786316	0.00108721036047238	0.00104105068590519	0.000866129238952124	79
SARC	RPS27	0.617539534655574	-0.482012188795713	0.00237811994677509	0.00210958029249705	0.00240471753391219	265
ACC	RPS27	0.469426203864914	-0.756244172954357	0.00550375473323023	0.00793259575029967	0.00513160564290384	79
UVM	RPS27	0.399158362406273	-0.918397042574218	0.009333441227859	0.00850357956851408	0.0073771467412135	80
KIRC	RPS27	1.35904732673344	0.306783959237727	0.0093956476806098	0.0113414503801029	0.00962399046254078	604
KIRC	RPS27	1.35904732673344	0.306783959237727	0.0093956476806098	0.0113414503801029	0.00962399046254078	604
LGG	RPS27	1.47000825848514	0.385268018791964	0.00999639508017278	0.0109832406796623	0.0101455273797047	525
LIHC	RPS27	0.750672365279324	-0.286785987017184	0.0102737172906278	0.0105957775598112	0.0102145869071087	417
LIHC	RPS27	0.750672365279324	-0.286785987017184	0.0102737172906278	0.0105957775598112	0.0102145869071087	417
LUSC	RPS27	0.774117990478092	-0.256030974532428	0.0120249427625474	0.011476172461856	0.0119683890907127	545
PAAD	RPS27	1.6413093794025	0.495494325357408	0.0148648717347159	0.0145310146451128	0.0151138502296941	182
PAAD	RPS27	1.6413093794025	0.495494325357408	0.0148648717347159	0.0145310146451128	0.0151138502296941	182
KIRP	RPS27	1.54333264865876	0.4339441357963	0.0386934148994546	0.0445332081676399	0.0390915787892806	320
KIRP	RPS27	1.54333264865876	0.4339441357963	0.0386934148994546	0.0445332081676399	0.0390915787892806	320
LUSC	RPS27	1.21043902294962	0.190983122686149	0.0396262281633895	0.0417369123191189	0.0396570728744243	545
UVM	RPS27	2.43577938171037	0.890266779945978	0.0410700893717774	0.0349340943278762	0.0378399301238935	80
LGG	RPS27	0.463026847008652	-0.769970241677065	2.50763912652287e-05	1.69896509980376e-05	3.66169437082066e-05	525

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
COAD	RPS27	0.00968819356441394	0.27
PCPG	RPS27	0.029582518502962	0.8
THYM	RPS27	0.0430045064628933	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	RPS27	0.0473284164485158	1
UVM	RPS27	0.00899100362138528	0.3

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1260899	Anemia, Diamond-Blackfan	2	GENOMICS_ENGLAND;ORPHANET
C2931850	Aase Smith syndrome 2	1	ORPHANET
C4479428	DIAMOND-BLACKFAN ANEMIA 17	1	CTD_human;GENOMICS_ENGLAND