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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS27A (NCBI Gene ID:6233)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS27A
	Gene ID: 6233
	Gene Symbol	RPS27A
	Gene ID	6233
	Gene Name	ribosomal protein S27a
	Synonyms	CEP80\|HEL112\|S27A\|UBA80\|UBC\|UBCEP1\|UBCEP80
	Cytomap	2p16.1
	Type of Gene	protein-coding
	Description	ubiquitin-40S ribosomal protein S27a40S ribosomal protein S27aepididymis luminal protein 112ubiquitin Cubiquitin and ribosomal protein S27aubiquitin carboxyl extension protein 80ubiquitin-CEP80
	Modification date	20200313
	UniProtAcc	P62979

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS27A	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS27A[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS27A	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000272317	55460498	55460553	Frame-shift
ENST00000402285	55460498	55460553	Frame-shift
ENST00000404735	55460498	55460553	Frame-shift
ENST00000272317	55461254	55461340	Frame-shift
ENST00000402285	55461254	55461340	Frame-shift
ENST00000404735	55461254	55461340	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	RPS27A	1.75396693785956	0.000187873840332031
BLCA	RPS27A	-1.04747470069188	0.0258216857910156
BRCA	RPS27A	-4.28512148200424	7.8788217967112e-14

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LGG	RPS27A	-0.034376644	0.027838853
LUAD	RPS27A	0.094568588	0.029673455
OV	RPS27A	-0.049285603	0.049962395

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS27A (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	RPS27A	SNRPD2	0.831779171	1.47E-12
CHOL	CGC	RPS27A	NACA	0.835292131	9.68E-13
CHOL	Epifactor	RPS27A	FBL	0.864083747	2.10E-14
CHOL	TSG	RPS27A	GLTSCR2	0.816822939	7.81E-12
CHOL	TSG	RPS27A	GNB2L1	0.872409569	5.90E-15
DLBC	Cell metabolism gene	RPS27A	TIMM13	0.8016428	7.60E-12
DLBC	Cell metabolism gene	RPS27A	GEMIN7	0.802195622	7.18E-12
DLBC	Cell metabolism gene	RPS27A	HSCB	0.806610301	4.49E-12
DLBC	Cell metabolism gene	RPS27A	TIMM9	0.809700648	3.22E-12
DLBC	Cell metabolism gene	RPS27A	PTDSS2	0.812440094	2.38E-12
DLBC	Cell metabolism gene	RPS27A	POLR2J	0.828714329	3.55E-13
DLBC	Cell metabolism gene	RPS27A	PFDN5	0.831327444	2.57E-13
DLBC	Cell metabolism gene	RPS27A	POLR2F	0.834019289	1.83E-13
DLBC	Cell metabolism gene	RPS27A	GFER	0.839091644	9.50E-14
DLBC	Cell metabolism gene	RPS27A	NME2	0.843658791	5.16E-14
DLBC	Cell metabolism gene	RPS27A	FAU	0.854214519	1.17E-14
DLBC	Cell metabolism gene	RPS27A	SNRPD2	0.863865009	2.69E-15
DLBC	Cell metabolism gene	RPS27A	TOMM22	0.896070903	7.75E-18
DLBC	CGC	RPS27A	NACA	0.813643524	2.08E-12
DLBC	Epifactor	RPS27A	FBL	0.826335947	4.75E-13
DLBC	TF	RPS27A	THAP7	0.803560543	6.22E-12
DLBC	TF	RPS27A	NME2	0.843658791	5.16E-14
DLBC	TSG	RPS27A	GADD45GIP1	0.835498741	1.52E-13
DLBC	TSG	RPS27A	GNB2L1	0.854197819	1.17E-14
HNSC	Cell metabolism gene	RPS27A	PFDN5	0.801877924	2.96E-128
KICH	Cell metabolism gene	RPS27A	LSM2	0.800294254	1.78E-21
LGG	Cell metabolism gene	RPS27A	FAU	0.858270152	4.34E-155
LGG	CGC	RPS27A	NACA	0.839501974	5.51E-142
LGG	TSG	RPS27A	GAS5	0.801082479	8.85E-120
PRAD	Cell metabolism gene	RPS27A	FAU	0.812892279	9.31E-131
PRAD	Cell metabolism gene	RPS27A	SNRPD2	0.821207901	1.26E-135
PRAD	Cell metabolism gene	RPS27A	TIMM9	0.823480429	5.30E-137
PRAD	Cell metabolism gene	RPS27A	TOMM7	0.830762547	1.52E-141
PRAD	CGC	RPS27A	NACA	0.801368967	2.13E-124
PRAD	Epifactor	RPS27A	FBL	0.872604349	1.13E-172
PRAD	TSG	RPS27A	GNB2L1	0.818109977	8.76E-134
THYM	Cell metabolism gene	RPS27A	IMPDH2	0.805423031	4.94E-29
THYM	Cell metabolism gene	RPS27A	TOMM7	0.805811658	4.44E-29
THYM	Cell metabolism gene	RPS27A	TIMM8B	0.80670021	3.47E-29
THYM	Cell metabolism gene	RPS27A	TIMM13	0.81864189	1.11E-30
THYM	Cell metabolism gene	RPS27A	SNRPD2	0.819345768	8.95E-31
THYM	Cell metabolism gene	RPS27A	PFDN5	0.833401082	1.08E-32
THYM	Cell metabolism gene	RPS27A	SLC27A5	0.833464936	1.06E-32
THYM	Cell metabolism gene	RPS27A	FAU	0.833991353	8.92E-33
THYM	Cell metabolism gene	RPS27A	SSR2	0.854472071	6.29E-36
THYM	CGC	RPS27A	SDHAF2	0.809663299	1.51E-29
THYM	Epifactor	RPS27A	RRP8	0.825320624	1.44E-31
THYM	Epifactor	RPS27A	FBL	0.869697821	1.33E-38
THYM	IUPHAR	RPS27A	IMPDH2	0.805423031	4.94E-29
THYM	IUPHAR	RPS27A	SLC27A5	0.833464936	1.06E-32
THYM	TF	RPS27A	REXO4	0.805974708	4.24E-29
THYM	TF	RPS27A	ZNF581	0.840118685	1.13E-33
THYM	TSG	RPS27A	TSSC4	0.832392029	1.51E-32
UCS	Cell metabolism gene	RPS27A	IMPDH2	0.805423031	4.94E-29
UCS	Cell metabolism gene	RPS27A	TOMM7	0.805811658	4.44E-29
UCS	Cell metabolism gene	RPS27A	TIMM8B	0.80670021	3.47E-29
UCS	Cell metabolism gene	RPS27A	TIMM13	0.81864189	1.11E-30
UCS	Cell metabolism gene	RPS27A	SNRPD2	0.819345768	8.95E-31
UCS	Cell metabolism gene	RPS27A	PFDN5	0.833401082	1.08E-32
UCS	Cell metabolism gene	RPS27A	SLC27A5	0.833464936	1.06E-32
UCS	Cell metabolism gene	RPS27A	FAU	0.833991353	8.92E-33
UCS	Cell metabolism gene	RPS27A	SSR2	0.854472071	6.29E-36
UCS	CGC	RPS27A	SDHAF2	0.809663299	1.51E-29
UCS	Epifactor	RPS27A	RRP8	0.825320624	1.44E-31
UCS	Epifactor	RPS27A	FBL	0.869697821	1.33E-38
UCS	IUPHAR	RPS27A	IMPDH2	0.805423031	4.94E-29
UCS	IUPHAR	RPS27A	SLC27A5	0.833464936	1.06E-32
UCS	TF	RPS27A	REXO4	0.805974708	4.24E-29
UCS	TF	RPS27A	ZNF581	0.840118685	1.13E-33
UCS	TSG	RPS27A	TSSC4	0.832392029	1.51E-32

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPS27A	RPL18A	-1.51651392808885	0.00016188295558095
KIRP	RPS27A	RPS16	-1.35957043617517	0.00019507110118866
STAD	RPS27A	RPS23	1.85076760664576	0.000364991836249828
COAD	RPS27A	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPS27A	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPS27A	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPS27A	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPS27A	RPL19	1.36901182894089	0.00250792503356934
KICH	RPS27A	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPS27A	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPS27A	RPS16	-6.16322798156577	0.0115764821363307
LUSC	RPS27A	RPS23	1.46751169891047	0.0174932185880974
BLCA	RPS27A	RPS12	-1.47804673440421	0.0204124450683594
HNSC	RPS27A	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPS27A	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPS27A	RPL19	-2.14669889516666	0.044366810398747
UCEC	RPS27A	RPS23	-2.03658159814007	0.046875
KIRC	RPS27A	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPS27A	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPS27A	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPS27A	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPS27A	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPS27A	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPS27A	RPS16	-1.66149869889384	7.8509870430991e-09
KIRC	RPS27A	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPS27A	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPS27A	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPS27A	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS27A

MDM2, RAD21, ARRB1, ARRB2, ISG15, FBXO25, CDK2, APP, PAXIP1, RPL10A, RPL18A, RPL18, RPL19, RPL5, RPL6, RPL7A, RPL9, RPS16, RPS19, RPS23, RPS24, RPS26, RPS2, RPS8, RPS4X, RPL21, RPS13, RPS11, RPS3A, RPS6, RPL15, RPL14, RPSA, RPLP0, RPS15A, RPL4, RPL17, RPS3, RPL37A, RPL23, RPL23A, RPL24, RPS12, RPS5, RPL11, RPLP1, RPL31, RPL22, RPS10, RHOA, RPLP0P6, RPS10P5, PTGES3, HNRNPA2B1, PHGDH, NSUN2, STRAP, RPL10L, TARS, TAF10, FN1, VCAM1, SMAD2, ZNF512B, RNF11, UBL4A, ITGA4, PAN2, CDK11B, PARK2, TUBA4A, rev, TP53, TRIM25, AP2M1, UBASH3B, ERRFI1, DAZAP2, CALCOCO2, EED, CTSG, THAP7, HNRNPA1, UBA52, BLM, PTEN, EWSR1, HIST1H3E, RPL10, VCL, Rrbp1, RAD6, GAN, CRY1, MCM2, MCM5, GRB2, ERBB3, ESRRB, CDC73, CDC25C, UBAC1, FAM78B, FARP2, ZNF274, CCDC89, ZNF408, ZNF263, ZNF133, MAK16, H2AFX, ZNF71, BHLHA15, ZNF764, ZCRB1, TLK2, CPNE4, CPNE7, SYNCRIP, MDK, ZNF324B, E4F1, PTPN5, WBP2, CYLD, FAM63A, RPL35, SNAPC1, UBA2, ACO2, MAPK6, WDR77, CTNNB1, HDAC4, MED12, MED9, CCNT1, TBX3, CUL4B, UBE2M, TRAF6, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, CHD4, ADRM1, NEDD8, RPS27A, SPDL1, RIOK1, HEXIM1, MEPCE, LARP7, WWP1, KIAA1429, USP18, RC3H1, RC3H2, ZC3H7A, TMEM41B, HRAS, KRAS, NR2C2, PPP1CC, PRDM16, MECOM, VRK1, HIST1H4A, PSMD14, RARA, P2RY6, ITFG1, WWP2, TRIM28, EPN3, FAM168A, DESI1, PLSCR4, PLEKHB2, UBQLN1, RAD23A, MTURN, UBQLN2, LITAF, PLEKHA4, WHSC1, HCVgp1, USP14, ZC3H18, AKT1, ARAF, BRAF, GAB1, HDAC1, PEBP1, PRKCE, RAC1, RIPK1, SH3BGRL, M, ORF3a, ORF7b, S, E, UBR5, NEK4, CIT, CHMP4C, ARHGEF10L, ARHGEF16, DOCK8, ARHGAP36, ARHGEF15, DOCK9, NET1, PLEKHG7, RASGRF2, C6orf203, MRPL11, MTRF1, NMRAL1, USP38, BRD4, NUPR1, UCHL1, Apc2, RNF208, RIN3, DNAJB2, DNAJC5B, SFMBT1, PRDM7, AMFR, RNF185, UFL1, DDRGK1, TRIM37, WDR5, NAA40, MYBBP1A, ZNF780A, ZNF346, PRKRA, SRSF1, ZNF485, DDX21, THAP3, RPL26, ZKSCAN8, NOTCH2, RPL13A, HIST1H2AB, KRR1, HIST1H3J, RBM47, HIST1H1D, SRSF6, H1FOO, RSL1D1, CLK3, C6orf141, ZC3H3, CLASRP, PURG, LRRC73, LIN28A, LRRC42, TRMT10B, HIST1H1A, FGFBP1, RPL36AL, CHIA, BTF3, ESR1, ZFYVE1, FSCN1, RBPMS, MAP1LC3B, SQSTM1, OPTN, TAX1BP1, DDX3X, GLTSCR2,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPS27A	chr2	55460605	A	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS27A	chr2	55460606	CCTGT	C	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS27A	chr2	55460611	AGGT	A	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS27A	chr2	55460751	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS27A	chr2	55461053	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS27A	chr2	55461409	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS27A	chr2	55461823	T	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS27A	chr2	55461964	C	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS27A	chr2	55461991	A	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPS27A	chr2	55462463	A	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPS27A	chr2	55462523	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS27A	HNSC	chr2	55460509	55460509	C	G	Missense_Mutation	p.S20W	3
RPS27A	BLCA	chr2	55461976	55461976	C	G	Missense_Mutation	p.L67V	2
RPS27A	STAD	chr2	55461288	55461288	C	T	Missense_Mutation	p.A46V	2
RPS27A	CESC	chr2	55459972	55459972	C	T	Silent		2
RPS27A	STAD	chr2	55462594	55462594	C	T	Missense_Mutation	p.R118C	2
RPS27A	UCEC	chr2	55460516	55460516	G	A	Silent	p.T22	2
RPS27A	UCEC	chr2	55461327	55461327	A	G	Missense_Mutation	p.Y59C	2
RPS27A	UCEC	chr2	55462017	55462019	GAA	-	In_Frame_Del	p.K83in_frame_del	2
RPS27A	HNSC	chr2	55462059	55462059	G	A	Silent	p.K94K	2
RPS27A	UCEC	chr2	55462068	55462068	G	T	Missense_Mutation	p.K97N	2
RPS27A	UCEC	chr2	55462577	55462577	G	A	Missense_Mutation	p.G112D	2
RPS27A	LIHC	chr2	55462628	55462628	G	A	Missense_Mutation		2
RPS27A	SKCM	chr2	55462591	55462591	C	A	Missense_Mutation	p.L117I	2
RPS27A	LIHC	chr2	55461316	55461316	T	-	Frame_Shift_Del	p.T55fs	2
RPS27A	LIHC	chr2	55460543	55460543	G	A	Silent	p.Q31Q	1
RPS27A	LUAD	chr2	55462635	55462635	T	C	Silent	p.F131F	1
RPS27A	CESC	chr2	55459972	55459972	C	T	Silent	p.F4F	1
RPS27A	OV	chr2	55462090	55462090	T	C	Missense_Mutation	p.Y105H	1
RPS27A	UCEC	chr2	55462017	55462019	GAA	-	In_Frame_Del	p.K83del	1
RPS27A	HNSC	chr2	55462059	55462059	G	A	Silent		1
RPS27A	PAAD	chr2	55462588	55462588	C	A	Missense_Mutation		1
RPS27A	HNSC	chr2	55460509	55460509	C	G	Missense_Mutation		1
RPS27A	PCPG	chr2	55460001	55460001	C	T	Missense_Mutation	p.T14I	1
RPS27A	PCPG	chr2	55460001	55460001	C	T	Missense_Mutation		1
RPS27A	PRAD	chr2	55462017	55462019	GAA	-	In_Frame_Del	p.80_81del	1
RPS27A	LGG	chr2	55462648	55462648	T	C	Missense_Mutation	p.F136L	1
RPS27A	PRAD	chr2	55462094	55462094	A	G	Missense_Mutation	p.Y106C	1
RPS27A	LIHC	chr2	55461991	55461991	A	C	Silent		1
RPS27A	PRAD	chr2	55462017	55462019	GAA	-	In_Frame_Del	p.RK80del	1
RPS27A	BLCA	chr2	55461976	55461976	C	G	Missense_Mutation		1
RPS27A	BLCA	chr2	55462651	55462651	G	T	Missense_Mutation		1
RPS27A	SKCM	chr2	55459989	55459989	G	A	Missense_Mutation	p.G10E	1

Copy number variation (CNV) of RPS27A
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS27A
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Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102618	STAD	TCGA-BR-6566	CSNK2A1	chr20	508576	-	RPS27A	chr2	55459943	+
102618	BRCA	TCGA-BH-A0BT	DNAAF2	chr14	50100004	-	RPS27A	chr2	55461966	+
102618	N/A	BQ946630	IFNAR1	chr21	34727789	+	RPS27A	chr2	55460532	+
102618	LUSC	TCGA-22-5492	MTIF2	chr2	55463769	-	RPS27A	chr2	55460499	+
102618	N/A	AA492364	MTIF2	chr2	55462564	-	RPS27A	chr2	55462743	-
102618	N/A	AA528259	MTIF2	chr2	55462564	-	RPS27A	chr2	55462741	-
102618	N/A	AA714961	MTIF2	chr2	55462593	-	RPS27A	chr2	55462749	-
102618	N/A	BG059465	MTIF2	chr2	55462564	-	RPS27A	chr2	55462745	-
102618	N/A	EC442375	MTIF2	chr2	55462732	-	RPS27A	chr2	55462730	-
102618	STAD	TCGA-BR-A4PD-01A	NCAM2	chr21	22849792	+	RPS27A	chr2	55459944	+
102618	N/A	BU928413	PRPF40B	chr12	50001018	+	RPS27A	chr2	55462019	+
99835	COAD	TCGA-AA-A00D-01A	RPS27A	chr2	55459986	+	ETV5	chr3	185826703	-
77752	N/A	BG272887	RPS27A	chr2	55462562	-	GALNT13	chr2	154743688	+
77752	THCA	TCGA-DJ-A3V2-01A	RPS27A	chr2	55462040	+	IGKC	chr2	89161435	-
99954	N/A	BF375146	RPS27A	chr2	55462629	+	LIPH	chr3	185232763	-
101479	BRCA	TCGA-BH-A0RX-01A	RPS27A	chr2	55462098	+	MS4A4A	chr11	60064670	+
78580	N/A	AA658829	RPS27A	chr2	55462745	+	MTIF2	chr2	55462564	+
78580	N/A	AW023019	RPS27A	chr2	55462745	+	MTIF2	chr2	55462655	+
78580	N/A	BF244266	RPS27A	chr2	55462708	+	MTIF2	chr2	55462710	+
78580	N/A	BF246442	RPS27A	chr2	55462699	+	MTIF2	chr2	55462701	+
78580	N/A	BG033492	RPS27A	chr2	55462744	+	MTIF2	chr2	55462564	+
78580	N/A	BG575191	RPS27A	chr2	55462741	+	MTIF2	chr2	55462564	+
78580	N/A	CF122644	RPS27A	chr2	55462739	+	MTIF2	chr2	55462564	+
78580	N/A	CF123715	RPS27A	chr2	55462743	+	MTIF2	chr2	55462564	+
78580	N/A	CF124463	RPS27A	chr2	55462743	+	MTIF2	chr2	55462710	+
95762	STAD	TCGA-CG-5719	RPS27A	chr2	55462098	+	PARP9	chr3	122255189	-
100607	ESCA	TCGA-L7-A6VZ	RPS27A	chr2	55461340	+	TIA1	chr2	70444126	-
102618	COAD	TCGA-A6-6650	SPATS2L	chr2	201194203	+	RPS27A	chr2	55459943	+
102618	CESC	TCGA-EA-A4BA	STX3	chr11	59560987	+	RPS27A	chr2	55459943	+
102618	N/A	DA583490	TOX4	chr14	21946363	-	RPS27A	chr2	55460973	+
102618	N/A	AA533239	TRAPPC9	chr8	141116128	-	RPS27A	chr2	55462743	-
102618	BRCA	TCGA-AO-A1KR-01A	XDH	chr2	31562355	-	RPS27A	chr2	55461967	+
102622	STAD	TCGA-HU-A4GN-01A	ZNF638	chr2	71627648	+	RPS27A	chr2	55460499	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BRCA	RPS27A	0.0218729935036365	0.61
KIRC	RPS27A	0.0390936181942416	1
THYM	RPS27A	0.0424797427618753	1
COAD	RPS27A	0.0432966185140386	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	RPS27A	0.026830686289865	0.83
KIRC	RPS27A	0.016280258267623	0.52
BRCA	RPS27A	0.000134584541473524	0.0044
BLCA	RPS27A	0.029339069549203	0.88

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C1260899	Anemia, Diamond-Blackfan	1	GENOMICS_ENGLAND