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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPS11 (NCBI Gene ID:64963)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPS11
	Gene ID: 64963
	Gene Symbol	MRPS11
	Gene ID	64963
	Gene Name	mitochondrial ribosomal protein S11
	Synonyms	HCC-2\|MRP-S11\|S11mt
	Cytomap	15q25.3
	Type of Gene	protein-coding
	Description	28S ribosomal protein S11, mitochondrialcervical cancer proto-oncogene 2 proteinmitochondrial small ribosomal subunit protein uS11m
	Modification date	20200320
	UniProtAcc	P82912

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPS11	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPS11[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPS11	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000325844	89015857	89015956	In-frame
ENST00000325844	89018340	89018470	Frame-shift
ENST00000325844	89020219	89020285	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000325844	89015857	89015956	1879	448	546	194	61	93
ENST00000325844	89020219	89020285	1879	677	742	194	137	159

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P82912	61	93	62	94	Alternative sequence	ID=VSP_005720;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
THCA	MRPS11	-3.10694728540962	0.0252226935182201
BLCA	MRPS11	-2.30276998968219	0.040130615234375
BRCA	MRPS11	-1.24304977976804	2.31302509538916e-07
LUSC	MRPS11	-2.9004097541444	5.43966600483641e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
HNSC	MRPS11	2	1	0.0405430131742181	0.219792592592593	0.137476991150442	0.00808160228860999	-0.21767497588251
LIHC	MRPS11	2	1	0.03025575746514	0.223937037037037	0.121582520650147	0.1681266022884	-0.216378373730659

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LAML	MRPS11	-0.034890082	0.018050342
LGG	MRPS11	0.088545376	0.026481063
LUSC	MRPS11	0.106854316	0.034647223
UVM	MRPS11	0.176076442	0.048193449

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPS11 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	MRPS11	POLR2F	0.800874526	8.24E-12
DLBC	Cell metabolism gene	MRPS11	POLR2L	0.801534914	7.69E-12
DLBC	Cell metabolism gene	MRPS11	MIF	0.803497418	6.26E-12
DLBC	Cell metabolism gene	MRPS11	PSMC3	0.807851944	3.93E-12
DLBC	Cell metabolism gene	MRPS11	TIMM13	0.810573492	2.92E-12
DLBC	Cell metabolism gene	MRPS11	HSD17B10	0.817830049	1.29E-12
DLBC	Cell metabolism gene	MRPS11	PSMB3	0.820827613	9.14E-13
DLBC	Cell metabolism gene	MRPS11	TPI1	0.834336594	1.76E-13
DLBC	Cell metabolism gene	MRPS11	SNRPD3	0.836056052	1.41E-13
DLBC	Cell metabolism gene	MRPS11	NME2	0.837106386	1.23E-13
DLBC	Cell metabolism gene	MRPS11	PSMD13	0.844165519	4.82E-14
DLBC	Cell metabolism gene	MRPS11	TOMM22	0.854953121	1.05E-14
DLBC	Cell metabolism gene	MRPS11	PSMA4	0.88713593	4.68E-17
DLBC	Epifactor	MRPS11	RBX1	0.840888831	7.49E-14
DLBC	IUPHAR	MRPS11	MFSD2B	0.802375741	7.04E-12
DLBC	TF	MRPS11	NME2	0.837106386	1.23E-13
DLBC	TSG	MRPS11	GADD45GIP1	0.812499466	2.36E-12
DLBC	TSG	MRPS11	PARK7	0.813188732	2.19E-12
DLBC	TSG	MRPS11	ST20	0.834105747	1.81E-13
GBM	Cell metabolism gene	MRPS11	CYC1	0.805872737	1.53E-40
GBM	Cell metabolism gene	MRPS11	PSMB3	0.832848265	1.57E-45
PRAD	Cell metabolism gene	MRPS11	PSMB6	0.808502556	2.77E-128
PRAD	Cell metabolism gene	MRPS11	PSMB3	0.810506092	2.10E-129
PRAD	Cell metabolism gene	MRPS11	TIMM50	0.812981224	8.28E-131
PRAD	Cell metabolism gene	MRPS11	POLR2I	0.814216039	1.62E-131
PRAD	Cell metabolism gene	MRPS11	ATP5G1	0.820978864	1.73E-135
PRAD	Cell metabolism gene	MRPS11	HSD17B10	0.835555083	1.18E-144
PRAD	CGC	MRPS11	ASPSCR1	0.802811306	3.59E-125
PRAD	Epifactor	MRPS11	RBX1	0.802348514	6.37E-125
PRAD	IUPHAR	MRPS11	PSMB6	0.808502556	2.77E-128
PRAD	TSG	MRPS11	PHB	0.80067446	4.99E-124
PRAD	TSG	MRPS11	GADD45GIP1	0.815563209	2.70E-132
THCA	Cell metabolism gene	MRPS11	ATP5G1	0.801381841	2.53E-129
THCA	Cell metabolism gene	MRPS11	HSD17B10	0.804115914	7.47E-131
THYM	Cell metabolism gene	MRPS11	SNRPD1	0.800016869	2.15E-28
THYM	Cell metabolism gene	MRPS11	TXN	0.802038052	1.25E-28
THYM	Cell metabolism gene	MRPS11	GMPPA	0.804892085	5.72E-29
THYM	Cell metabolism gene	MRPS11	GSTZ1	0.805145623	5.33E-29
THYM	Cell metabolism gene	MRPS11	FPGS	0.805483356	4.86E-29
THYM	Cell metabolism gene	MRPS11	PCYT2	0.806593613	3.57E-29
THYM	Cell metabolism gene	MRPS11	TAZ	0.806637299	3.53E-29
THYM	Cell metabolism gene	MRPS11	MVD	0.806911087	3.27E-29
THYM	Cell metabolism gene	MRPS11	PSME1	0.810918175	1.06E-29
THYM	Cell metabolism gene	MRPS11	DHRS4	0.812954732	5.88E-30
THYM	Cell metabolism gene	MRPS11	SRM	0.813092991	5.65E-30
THYM	Cell metabolism gene	MRPS11	PSMC5	0.816812421	1.91E-30
THYM	Cell metabolism gene	MRPS11	DPM2	0.817396673	1.60E-30
THYM	Cell metabolism gene	MRPS11	GCDH	0.817501547	1.55E-30
THYM	Cell metabolism gene	MRPS11	LSM5	0.817563041	1.53E-30
THYM	Cell metabolism gene	MRPS11	POLE4	0.820983629	5.46E-31
THYM	Cell metabolism gene	MRPS11	SLC27A5	0.822140314	3.84E-31
THYM	Cell metabolism gene	MRPS11	AK2	0.822391603	3.56E-31
THYM	Cell metabolism gene	MRPS11	DHRS4L2	0.822716815	3.22E-31
THYM	Cell metabolism gene	MRPS11	PPCDC	0.824583558	1.81E-31
THYM	Cell metabolism gene	MRPS11	CCT7	0.825301725	1.45E-31
THYM	Cell metabolism gene	MRPS11	ITPA	0.825541397	1.34E-31
THYM	Cell metabolism gene	MRPS11	PSMA6	0.825776235	1.25E-31
THYM	Cell metabolism gene	MRPS11	TPI1	0.825878758	1.21E-31
THYM	Cell metabolism gene	MRPS11	PSMC4	0.827516804	7.22E-32
THYM	Cell metabolism gene	MRPS11	UROS	0.829091822	4.38E-32
THYM	Cell metabolism gene	MRPS11	NME1	0.82929931	4.10E-32
THYM	Cell metabolism gene	MRPS11	POLR3K	0.830706564	2.61E-32
THYM	Cell metabolism gene	MRPS11	TIMM10	0.830938784	2.42E-32
THYM	Cell metabolism gene	MRPS11	PREB	0.831150574	2.26E-32
THYM	Cell metabolism gene	MRPS11	PSME2	0.831309565	2.14E-32
THYM	Cell metabolism gene	MRPS11	TOMM5	0.832333241	1.54E-32
THYM	Cell metabolism gene	MRPS11	HMBS	0.832609472	1.40E-32
THYM	Cell metabolism gene	MRPS11	GALK1	0.832944249	1.26E-32
THYM	Cell metabolism gene	MRPS11	GSS	0.833140037	1.18E-32
THYM	Cell metabolism gene	MRPS11	NOP56	0.833849421	9.35E-33
THYM	Cell metabolism gene	MRPS11	TBCB	0.83526633	5.85E-33
THYM	Cell metabolism gene	MRPS11	IDH3B	0.836645899	3.69E-33
THYM	Cell metabolism gene	MRPS11	PSMB10	0.837697122	2.59E-33
THYM	Cell metabolism gene	MRPS11	DPM3	0.838068689	2.28E-33
THYM	Cell metabolism gene	MRPS11	EXOSC5	0.841977412	5.96E-34
THYM	Cell metabolism gene	MRPS11	GEMIN6	0.844797289	2.21E-34
THYM	Cell metabolism gene	MRPS11	PSMA5	0.846001149	1.44E-34
THYM	Cell metabolism gene	MRPS11	PSMD13	0.846780658	1.09E-34
THYM	Cell metabolism gene	MRPS11	TSTA3	0.851592792	1.86E-35
THYM	Cell metabolism gene	MRPS11	DGUOK	0.852235097	1.46E-35
THYM	Cell metabolism gene	MRPS11	SNRPB	0.852806859	1.18E-35
THYM	Cell metabolism gene	MRPS11	PMPCA	0.852840045	1.17E-35
THYM	Cell metabolism gene	MRPS11	LSM3	0.855919478	3.61E-36
THYM	Cell metabolism gene	MRPS11	PGLS	0.857364244	2.06E-36
THYM	Cell metabolism gene	MRPS11	POLR2J	0.857949917	1.64E-36
THYM	Cell metabolism gene	MRPS11	PSMA4	0.859543289	8.77E-37
THYM	Cell metabolism gene	MRPS11	PSMA7	0.860962637	4.98E-37
THYM	Cell metabolism gene	MRPS11	SUCLG1	0.86104615	4.82E-37
THYM	Cell metabolism gene	MRPS11	ATIC	0.86121151	4.51E-37
THYM	Cell metabolism gene	MRPS11	POLD2	0.862142902	3.10E-37
THYM	Cell metabolism gene	MRPS11	ATP5G1	0.863788378	1.59E-37
THYM	Cell metabolism gene	MRPS11	SEC61G	0.865563091	7.63E-38
THYM	Cell metabolism gene	MRPS11	PAFAH1B3	0.865689494	7.24E-38
THYM	Cell metabolism gene	MRPS11	CYC1	0.866092216	6.12E-38
THYM	Cell metabolism gene	MRPS11	HMOX2	0.8669131	4.34E-38
THYM	Cell metabolism gene	MRPS11	MTX1	0.866951587	4.27E-38
THYM	Cell metabolism gene	MRPS11	PSMB6	0.868331065	2.39E-38
THYM	Cell metabolism gene	MRPS11	POLR2H	0.870516357	9.36E-39
THYM	Cell metabolism gene	MRPS11	PSMC1	0.871004793	7.57E-39
THYM	Cell metabolism gene	MRPS11	TOMM22	0.871674871	5.66E-39
THYM	Cell metabolism gene	MRPS11	TIMM8B	0.872913826	3.28E-39
THYM	Cell metabolism gene	MRPS11	EXOSC4	0.875298659	1.13E-39
THYM	Cell metabolism gene	MRPS11	POLR2I	0.875433221	1.07E-39
THYM	Cell metabolism gene	MRPS11	PSMB2	0.876127699	7.80E-40
THYM	Cell metabolism gene	MRPS11	PGP	0.876879455	5.54E-40
THYM	Cell metabolism gene	MRPS11	PHKG2	0.877481627	4.20E-40
THYM	Cell metabolism gene	MRPS11	MED27	0.878257925	2.94E-40
THYM	Cell metabolism gene	MRPS11	PSMC3	0.879141126	1.95E-40
THYM	Cell metabolism gene	MRPS11	SNRPE	0.879205014	1.90E-40
THYM	Cell metabolism gene	MRPS11	PSMD8	0.88124066	7.28E-41
THYM	Cell metabolism gene	MRPS11	DTYMK	0.883108366	2.98E-41
THYM	Cell metabolism gene	MRPS11	NANS	0.892811426	2.21E-43
THYM	Cell metabolism gene	MRPS11	GEMIN7	0.893882628	1.25E-43
THYM	Cell metabolism gene	MRPS11	PSMB4	0.894260932	1.02E-43
THYM	Cell metabolism gene	MRPS11	TIMM13	0.894287841	1.01E-43
THYM	Cell metabolism gene	MRPS11	ACOT8	0.895127757	6.41E-44
THYM	Cell metabolism gene	MRPS11	LSM4	0.895976045	4.04E-44
THYM	Cell metabolism gene	MRPS11	APRT	0.898012459	1.31E-44
THYM	Cell metabolism gene	MRPS11	TIMM50	0.898703418	8.91E-45
THYM	Cell metabolism gene	MRPS11	EBP	0.899259165	6.52E-45
THYM	Cell metabolism gene	MRPS11	WBSCR22	0.899266436	6.49E-45
THYM	Cell metabolism gene	MRPS11	HSD17B10	0.900878178	2.59E-45
THYM	Cell metabolism gene	MRPS11	SNRPD2	0.901394935	1.92E-45
THYM	Cell metabolism gene	MRPS11	PSMB7	0.901700067	1.61E-45
THYM	Cell metabolism gene	MRPS11	PSMB3	0.902600601	9.54E-46
THYM	Cell metabolism gene	MRPS11	GUK1	0.904649398	2.83E-46
THYM	Cell metabolism gene	MRPS11	TOMM40	0.91781143	5.69E-50
THYM	Cell metabolism gene	MRPS11	TIMM17B	0.922885084	1.45E-51
THYM	Cell metabolism gene	MRPS11	PSMD4	0.926694202	7.78E-53
THYM	CGC	MRPS11	RBM10	0.813199519	5.48E-30
THYM	CGC	MRPS11	ATIC	0.86121151	4.51E-37
THYM	CGC	MRPS11	TFPT	0.862695311	2.48E-37
THYM	CGC	MRPS11	COX6C	0.878416317	2.73E-40
THYM	CGC	MRPS11	SDHAF2	0.888786029	1.79E-42
THYM	Epifactor	MRPS11	SUV39H1	0.802349873	1.15E-28
THYM	Epifactor	MRPS11	PRMT1	0.813052806	5.72E-30
THYM	Epifactor	MRPS11	INO80E	0.8172699	1.66E-30
THYM	Epifactor	MRPS11	C17orf49	0.819538614	8.45E-31
THYM	Epifactor	MRPS11	HMG20B	0.822407038	3.54E-31
THYM	Epifactor	MRPS11	FBL	0.823019494	2.93E-31
THYM	Epifactor	MRPS11	VPS72	0.823334729	2.66E-31
THYM	Epifactor	MRPS11	PPM1G	0.84150268	7.02E-34
THYM	Epifactor	MRPS11	SIRT6	0.841961255	5.99E-34
THYM	Epifactor	MRPS11	EXOSC5	0.841977412	5.96E-34
THYM	Epifactor	MRPS11	ZGPAT	0.849828559	3.58E-35
THYM	Epifactor	MRPS11	PPP4C	0.852908722	1.14E-35
THYM	Epifactor	MRPS11	PAF1	0.853304859	9.79E-36
THYM	Epifactor	MRPS11	RRP8	0.855642445	4.02E-36
THYM	Epifactor	MRPS11	RUVBL2	0.859277872	9.74E-37
THYM	Epifactor	MRPS11	TAF10	0.859808396	7.89E-37
THYM	Epifactor	MRPS11	LAS1L	0.862694326	2.48E-37
THYM	Epifactor	MRPS11	TFPT	0.862695311	2.48E-37
THYM	Epifactor	MRPS11	ZNHIT1	0.866686696	4.78E-38
THYM	Epifactor	MRPS11	EXOSC4	0.875298659	1.13E-39
THYM	Epifactor	MRPS11	BRMS1	0.897374263	1.87E-44
THYM	Epifactor	MRPS11	PRPF31	0.89909841	7.14E-45
THYM	Epifactor	MRPS11	CDK5	0.91727396	8.28E-50
THYM	IUPHAR	MRPS11	SUV39H1	0.802349873	1.15E-28
THYM	IUPHAR	MRPS11	SLC27A4	0.805386545	4.99E-29
THYM	IUPHAR	MRPS11	MVD	0.806911087	3.27E-29
THYM	IUPHAR	MRPS11	ATG4B	0.808924494	1.86E-29
THYM	IUPHAR	MRPS11	PRMT1	0.813052806	5.72E-30
THYM	IUPHAR	MRPS11	SLC27A5	0.822140314	3.84E-31
THYM	IUPHAR	MRPS11	UCHL3	0.828561227	5.18E-32
THYM	IUPHAR	MRPS11	ECE2	0.829651289	3.66E-32
THYM	IUPHAR	MRPS11	STK16	0.836593787	3.75E-33
THYM	IUPHAR	MRPS11	SLC39A3	0.838965695	1.68E-33
THYM	IUPHAR	MRPS11	SIRT6	0.841961255	5.99E-34
THYM	IUPHAR	MRPS11	PPIA	0.86153732	3.96E-37
THYM	IUPHAR	MRPS11	HMOX2	0.8669131	4.34E-38
THYM	IUPHAR	MRPS11	PSMB6	0.868331065	2.39E-38
THYM	IUPHAR	MRPS11	PSMB2	0.876127699	7.80E-40
THYM	IUPHAR	MRPS11	PHKG2	0.877481627	4.20E-40
THYM	IUPHAR	MRPS11	CDK5	0.91727396	8.28E-50
THYM	Kinase	MRPS11	FASTK	0.826851978	8.91E-32
THYM	Kinase	MRPS11	STK16	0.836593787	3.75E-33
THYM	Kinase	MRPS11	ADCK4	0.851289464	2.08E-35
THYM	Kinase	MRPS11	PHKG2	0.877481627	4.20E-40
THYM	Kinase	MRPS11	CDK5	0.91727396	8.28E-50
THYM	TF	MRPS11	GTF3A	0.80003889	2.14E-28
THYM	TF	MRPS11	DNTTIP1	0.800289473	2.00E-28
THYM	TF	MRPS11	IRF3	0.804009278	7.29E-29
THYM	TF	MRPS11	RBCK1	0.804162995	6.99E-29
THYM	TF	MRPS11	GLI4	0.807996565	2.41E-29
THYM	TF	MRPS11	ZNF581	0.813590276	4.89E-30
THYM	TF	MRPS11	THYN1	0.815478517	2.82E-30
THYM	TF	MRPS11	SNAPC2	0.816451625	2.12E-30
THYM	TF	MRPS11	THAP8	0.819042725	9.81E-31
THYM	TF	MRPS11	ZNF672	0.820198775	6.93E-31
THYM	TF	MRPS11	HMG20B	0.822407038	3.54E-31
THYM	TF	MRPS11	MYPOP	0.830540091	2.75E-32
THYM	TF	MRPS11	PREB	0.831150574	2.26E-32
THYM	TF	MRPS11	ZNF668	0.833314707	1.11E-32
THYM	TF	MRPS11	PIN1	0.839413214	1.44E-33
THYM	TF	MRPS11	DRAP1	0.843119076	4.00E-34
THYM	TF	MRPS11	ZNF787	0.844114564	2.81E-34
THYM	TF	MRPS11	ZGPAT	0.849828559	3.58E-35
THYM	TF	MRPS11	ZNF688	0.872075692	4.75E-39
THYM	TF	MRPS11	USF1	0.8776721	3.85E-40
THYM	TSG	MRPS11	PFN1	0.802842617	1.00E-28
THYM	TSG	MRPS11	IRF3	0.804009278	7.29E-29
THYM	TSG	MRPS11	MAD1L1	0.811505332	8.93E-30
THYM	TSG	MRPS11	NPRL2	0.81766089	1.48E-30
THYM	TSG	MRPS11	ST20	0.822129587	3.85E-31
THYM	TSG	MRPS11	NME1	0.82929931	4.10E-32
THYM	TSG	MRPS11	ZNF668	0.833314707	1.11E-32
THYM	TSG	MRPS11	GADD45GIP1	0.833678233	9.89E-33
THYM	TSG	MRPS11	STUB1	0.837690544	2.59E-33
THYM	TSG	MRPS11	PIN1	0.839413214	1.44E-33
THYM	TSG	MRPS11	PARK7	0.841062831	8.18E-34
THYM	TSG	MRPS11	PINX1	0.841859321	6.21E-34
THYM	TSG	MRPS11	SIRT6	0.841961255	5.99E-34
THYM	TSG	MRPS11	TSSC4	0.851633309	1.83E-35
THYM	TSG	MRPS11	BRMS1	0.897374263	1.87E-44
UCS	Cell metabolism gene	MRPS11	SNRPD1	0.800016869	2.15E-28
UCS	Cell metabolism gene	MRPS11	TXN	0.802038052	1.25E-28
UCS	Cell metabolism gene	MRPS11	GMPPA	0.804892085	5.72E-29
UCS	Cell metabolism gene	MRPS11	GSTZ1	0.805145623	5.33E-29
UCS	Cell metabolism gene	MRPS11	FPGS	0.805483356	4.86E-29
UCS	Cell metabolism gene	MRPS11	PCYT2	0.806593613	3.57E-29
UCS	Cell metabolism gene	MRPS11	TAZ	0.806637299	3.53E-29
UCS	Cell metabolism gene	MRPS11	MVD	0.806911087	3.27E-29
UCS	Cell metabolism gene	MRPS11	PSME1	0.810918175	1.06E-29
UCS	Cell metabolism gene	MRPS11	DHRS4	0.812954732	5.88E-30
UCS	Cell metabolism gene	MRPS11	SRM	0.813092991	5.65E-30
UCS	Cell metabolism gene	MRPS11	PSMC5	0.816812421	1.91E-30
UCS	Cell metabolism gene	MRPS11	DPM2	0.817396673	1.60E-30
UCS	Cell metabolism gene	MRPS11	GCDH	0.817501547	1.55E-30
UCS	Cell metabolism gene	MRPS11	LSM5	0.817563041	1.53E-30
UCS	Cell metabolism gene	MRPS11	POLE4	0.820983629	5.46E-31
UCS	Cell metabolism gene	MRPS11	SLC27A5	0.822140314	3.84E-31
UCS	Cell metabolism gene	MRPS11	AK2	0.822391603	3.56E-31
UCS	Cell metabolism gene	MRPS11	DHRS4L2	0.822716815	3.22E-31
UCS	Cell metabolism gene	MRPS11	PPCDC	0.824583558	1.81E-31
UCS	Cell metabolism gene	MRPS11	CCT7	0.825301725	1.45E-31
UCS	Cell metabolism gene	MRPS11	ITPA	0.825541397	1.34E-31
UCS	Cell metabolism gene	MRPS11	PSMA6	0.825776235	1.25E-31
UCS	Cell metabolism gene	MRPS11	TPI1	0.825878758	1.21E-31
UCS	Cell metabolism gene	MRPS11	PSMC4	0.827516804	7.22E-32
UCS	Cell metabolism gene	MRPS11	UROS	0.829091822	4.38E-32
UCS	Cell metabolism gene	MRPS11	NME1	0.82929931	4.10E-32
UCS	Cell metabolism gene	MRPS11	POLR3K	0.830706564	2.61E-32
UCS	Cell metabolism gene	MRPS11	TIMM10	0.830938784	2.42E-32
UCS	Cell metabolism gene	MRPS11	PREB	0.831150574	2.26E-32
UCS	Cell metabolism gene	MRPS11	PSME2	0.831309565	2.14E-32
UCS	Cell metabolism gene	MRPS11	TOMM5	0.832333241	1.54E-32
UCS	Cell metabolism gene	MRPS11	HMBS	0.832609472	1.40E-32
UCS	Cell metabolism gene	MRPS11	GALK1	0.832944249	1.26E-32
UCS	Cell metabolism gene	MRPS11	GSS	0.833140037	1.18E-32
UCS	Cell metabolism gene	MRPS11	NOP56	0.833849421	9.35E-33
UCS	Cell metabolism gene	MRPS11	TBCB	0.83526633	5.85E-33
UCS	Cell metabolism gene	MRPS11	IDH3B	0.836645899	3.69E-33
UCS	Cell metabolism gene	MRPS11	PSMB10	0.837697122	2.59E-33
UCS	Cell metabolism gene	MRPS11	DPM3	0.838068689	2.28E-33
UCS	Cell metabolism gene	MRPS11	EXOSC5	0.841977412	5.96E-34
UCS	Cell metabolism gene	MRPS11	GEMIN6	0.844797289	2.21E-34
UCS	Cell metabolism gene	MRPS11	PSMA5	0.846001149	1.44E-34
UCS	Cell metabolism gene	MRPS11	PSMD13	0.846780658	1.09E-34
UCS	Cell metabolism gene	MRPS11	TSTA3	0.851592792	1.86E-35
UCS	Cell metabolism gene	MRPS11	DGUOK	0.852235097	1.46E-35
UCS	Cell metabolism gene	MRPS11	SNRPB	0.852806859	1.18E-35
UCS	Cell metabolism gene	MRPS11	PMPCA	0.852840045	1.17E-35
UCS	Cell metabolism gene	MRPS11	LSM3	0.855919478	3.61E-36
UCS	Cell metabolism gene	MRPS11	PGLS	0.857364244	2.06E-36
UCS	Cell metabolism gene	MRPS11	POLR2J	0.857949917	1.64E-36
UCS	Cell metabolism gene	MRPS11	PSMA4	0.859543289	8.77E-37
UCS	Cell metabolism gene	MRPS11	PSMA7	0.860962637	4.98E-37
UCS	Cell metabolism gene	MRPS11	SUCLG1	0.86104615	4.82E-37
UCS	Cell metabolism gene	MRPS11	ATIC	0.86121151	4.51E-37
UCS	Cell metabolism gene	MRPS11	POLD2	0.862142902	3.10E-37
UCS	Cell metabolism gene	MRPS11	ATP5G1	0.863788378	1.59E-37
UCS	Cell metabolism gene	MRPS11	SEC61G	0.865563091	7.63E-38
UCS	Cell metabolism gene	MRPS11	PAFAH1B3	0.865689494	7.24E-38
UCS	Cell metabolism gene	MRPS11	CYC1	0.866092216	6.12E-38
UCS	Cell metabolism gene	MRPS11	HMOX2	0.8669131	4.34E-38
UCS	Cell metabolism gene	MRPS11	MTX1	0.866951587	4.27E-38
UCS	Cell metabolism gene	MRPS11	PSMB6	0.868331065	2.39E-38
UCS	Cell metabolism gene	MRPS11	POLR2H	0.870516357	9.36E-39
UCS	Cell metabolism gene	MRPS11	PSMC1	0.871004793	7.57E-39
UCS	Cell metabolism gene	MRPS11	TOMM22	0.871674871	5.66E-39
UCS	Cell metabolism gene	MRPS11	TIMM8B	0.872913826	3.28E-39
UCS	Cell metabolism gene	MRPS11	EXOSC4	0.875298659	1.13E-39
UCS	Cell metabolism gene	MRPS11	POLR2I	0.875433221	1.07E-39
UCS	Cell metabolism gene	MRPS11	PSMB2	0.876127699	7.80E-40
UCS	Cell metabolism gene	MRPS11	PGP	0.876879455	5.54E-40
UCS	Cell metabolism gene	MRPS11	PHKG2	0.877481627	4.20E-40
UCS	Cell metabolism gene	MRPS11	MED27	0.878257925	2.94E-40
UCS	Cell metabolism gene	MRPS11	PSMC3	0.879141126	1.95E-40
UCS	Cell metabolism gene	MRPS11	SNRPE	0.879205014	1.90E-40
UCS	Cell metabolism gene	MRPS11	PSMD8	0.88124066	7.28E-41
UCS	Cell metabolism gene	MRPS11	DTYMK	0.883108366	2.98E-41
UCS	Cell metabolism gene	MRPS11	NANS	0.892811426	2.21E-43
UCS	Cell metabolism gene	MRPS11	GEMIN7	0.893882628	1.25E-43
UCS	Cell metabolism gene	MRPS11	PSMB4	0.894260932	1.02E-43
UCS	Cell metabolism gene	MRPS11	TIMM13	0.894287841	1.01E-43
UCS	Cell metabolism gene	MRPS11	ACOT8	0.895127757	6.41E-44
UCS	Cell metabolism gene	MRPS11	LSM4	0.895976045	4.04E-44
UCS	Cell metabolism gene	MRPS11	APRT	0.898012459	1.31E-44
UCS	Cell metabolism gene	MRPS11	TIMM50	0.898703418	8.91E-45
UCS	Cell metabolism gene	MRPS11	EBP	0.899259165	6.52E-45
UCS	Cell metabolism gene	MRPS11	WBSCR22	0.899266436	6.49E-45
UCS	Cell metabolism gene	MRPS11	HSD17B10	0.900878178	2.59E-45
UCS	Cell metabolism gene	MRPS11	SNRPD2	0.901394935	1.92E-45
UCS	Cell metabolism gene	MRPS11	PSMB7	0.901700067	1.61E-45
UCS	Cell metabolism gene	MRPS11	PSMB3	0.902600601	9.54E-46
UCS	Cell metabolism gene	MRPS11	GUK1	0.904649398	2.83E-46
UCS	Cell metabolism gene	MRPS11	TOMM40	0.91781143	5.69E-50
UCS	Cell metabolism gene	MRPS11	TIMM17B	0.922885084	1.45E-51
UCS	Cell metabolism gene	MRPS11	PSMD4	0.926694202	7.78E-53
UCS	CGC	MRPS11	RBM10	0.813199519	5.48E-30
UCS	CGC	MRPS11	ATIC	0.86121151	4.51E-37
UCS	CGC	MRPS11	TFPT	0.862695311	2.48E-37
UCS	CGC	MRPS11	COX6C	0.878416317	2.73E-40
UCS	CGC	MRPS11	SDHAF2	0.888786029	1.79E-42
UCS	Epifactor	MRPS11	SUV39H1	0.802349873	1.15E-28
UCS	Epifactor	MRPS11	PRMT1	0.813052806	5.72E-30
UCS	Epifactor	MRPS11	INO80E	0.8172699	1.66E-30
UCS	Epifactor	MRPS11	C17orf49	0.819538614	8.45E-31
UCS	Epifactor	MRPS11	HMG20B	0.822407038	3.54E-31
UCS	Epifactor	MRPS11	FBL	0.823019494	2.93E-31
UCS	Epifactor	MRPS11	VPS72	0.823334729	2.66E-31
UCS	Epifactor	MRPS11	PPM1G	0.84150268	7.02E-34
UCS	Epifactor	MRPS11	SIRT6	0.841961255	5.99E-34
UCS	Epifactor	MRPS11	EXOSC5	0.841977412	5.96E-34
UCS	Epifactor	MRPS11	ZGPAT	0.849828559	3.58E-35
UCS	Epifactor	MRPS11	PPP4C	0.852908722	1.14E-35
UCS	Epifactor	MRPS11	PAF1	0.853304859	9.79E-36
UCS	Epifactor	MRPS11	RRP8	0.855642445	4.02E-36
UCS	Epifactor	MRPS11	RUVBL2	0.859277872	9.74E-37
UCS	Epifactor	MRPS11	TAF10	0.859808396	7.89E-37
UCS	Epifactor	MRPS11	LAS1L	0.862694326	2.48E-37
UCS	Epifactor	MRPS11	TFPT	0.862695311	2.48E-37
UCS	Epifactor	MRPS11	ZNHIT1	0.866686696	4.78E-38
UCS	Epifactor	MRPS11	EXOSC4	0.875298659	1.13E-39
UCS	Epifactor	MRPS11	BRMS1	0.897374263	1.87E-44
UCS	Epifactor	MRPS11	PRPF31	0.89909841	7.14E-45
UCS	Epifactor	MRPS11	CDK5	0.91727396	8.28E-50
UCS	IUPHAR	MRPS11	SUV39H1	0.802349873	1.15E-28
UCS	IUPHAR	MRPS11	SLC27A4	0.805386545	4.99E-29
UCS	IUPHAR	MRPS11	MVD	0.806911087	3.27E-29
UCS	IUPHAR	MRPS11	ATG4B	0.808924494	1.86E-29
UCS	IUPHAR	MRPS11	PRMT1	0.813052806	5.72E-30
UCS	IUPHAR	MRPS11	SLC27A5	0.822140314	3.84E-31
UCS	IUPHAR	MRPS11	UCHL3	0.828561227	5.18E-32
UCS	IUPHAR	MRPS11	ECE2	0.829651289	3.66E-32
UCS	IUPHAR	MRPS11	STK16	0.836593787	3.75E-33
UCS	IUPHAR	MRPS11	SLC39A3	0.838965695	1.68E-33
UCS	IUPHAR	MRPS11	SIRT6	0.841961255	5.99E-34
UCS	IUPHAR	MRPS11	PPIA	0.86153732	3.96E-37
UCS	IUPHAR	MRPS11	HMOX2	0.8669131	4.34E-38
UCS	IUPHAR	MRPS11	PSMB6	0.868331065	2.39E-38
UCS	IUPHAR	MRPS11	PSMB2	0.876127699	7.80E-40
UCS	IUPHAR	MRPS11	PHKG2	0.877481627	4.20E-40
UCS	IUPHAR	MRPS11	CDK5	0.91727396	8.28E-50
UCS	Kinase	MRPS11	FASTK	0.826851978	8.91E-32
UCS	Kinase	MRPS11	STK16	0.836593787	3.75E-33
UCS	Kinase	MRPS11	ADCK4	0.851289464	2.08E-35
UCS	Kinase	MRPS11	PHKG2	0.877481627	4.20E-40
UCS	Kinase	MRPS11	CDK5	0.91727396	8.28E-50
UCS	TF	MRPS11	GTF3A	0.80003889	2.14E-28
UCS	TF	MRPS11	DNTTIP1	0.800289473	2.00E-28
UCS	TF	MRPS11	IRF3	0.804009278	7.29E-29
UCS	TF	MRPS11	RBCK1	0.804162995	6.99E-29
UCS	TF	MRPS11	GLI4	0.807996565	2.41E-29
UCS	TF	MRPS11	ZNF581	0.813590276	4.89E-30
UCS	TF	MRPS11	THYN1	0.815478517	2.82E-30
UCS	TF	MRPS11	SNAPC2	0.816451625	2.12E-30
UCS	TF	MRPS11	THAP8	0.819042725	9.81E-31
UCS	TF	MRPS11	ZNF672	0.820198775	6.93E-31
UCS	TF	MRPS11	HMG20B	0.822407038	3.54E-31
UCS	TF	MRPS11	MYPOP	0.830540091	2.75E-32
UCS	TF	MRPS11	PREB	0.831150574	2.26E-32
UCS	TF	MRPS11	ZNF668	0.833314707	1.11E-32
UCS	TF	MRPS11	PIN1	0.839413214	1.44E-33
UCS	TF	MRPS11	DRAP1	0.843119076	4.00E-34
UCS	TF	MRPS11	ZNF787	0.844114564	2.81E-34
UCS	TF	MRPS11	ZGPAT	0.849828559	3.58E-35
UCS	TF	MRPS11	ZNF688	0.872075692	4.75E-39
UCS	TF	MRPS11	USF1	0.8776721	3.85E-40
UCS	TSG	MRPS11	PFN1	0.802842617	1.00E-28
UCS	TSG	MRPS11	IRF3	0.804009278	7.29E-29
UCS	TSG	MRPS11	MAD1L1	0.811505332	8.93E-30
UCS	TSG	MRPS11	NPRL2	0.81766089	1.48E-30
UCS	TSG	MRPS11	ST20	0.822129587	3.85E-31
UCS	TSG	MRPS11	NME1	0.82929931	4.10E-32
UCS	TSG	MRPS11	ZNF668	0.833314707	1.11E-32
UCS	TSG	MRPS11	GADD45GIP1	0.833678233	9.89E-33
UCS	TSG	MRPS11	STUB1	0.837690544	2.59E-33
UCS	TSG	MRPS11	PIN1	0.839413214	1.44E-33
UCS	TSG	MRPS11	PARK7	0.841062831	8.18E-34
UCS	TSG	MRPS11	PINX1	0.841859321	6.21E-34
UCS	TSG	MRPS11	SIRT6	0.841961255	5.99E-34
UCS	TSG	MRPS11	TSSC4	0.851633309	1.83E-35
UCS	TSG	MRPS11	BRMS1	0.897374263	1.87E-44

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	MRPS11	MRPS12	2.11566333114824	0.000125885009765625
KICH	MRPS11	MRPS5	1.25108287838437	0.000249803066253662
LIHC	MRPS11	MRPS7	1.27029395477208	0.00182077236082954
STAD	MRPS11	MRPS16	-1.64208084987431	0.00239070039242506
LIHC	MRPS11	MRPS18C	-1.25336042046698	0.00251545393492315
COAD	MRPS11	MRPS18C	-3.48505830240365	0.00322914123535157
ESCA	MRPS11	MRPS12	-1.86248549814506	0.0048828125
PRAD	MRPS11	MRPS9	1.04379115553269	0.00496210155254694
HNSC	MRPS11	MRPS16	-2.01564621821803	0.00518989327406416
KICH	MRPS11	MRPS2	1.26543989555015	0.0114533305168152
ESCA	MRPS11	MRPS5	-2.15440118747854	0.0185546875
ESCA	MRPS11	MRPS2	-3.20556788084675	0.0244140625
HNSC	MRPS11	MRPS12	1.33677139927136	0.0248336488591576
LUAD	MRPS11	MRPS12	-5.3399185683719	1.00823612619819e-08
THCA	MRPS11	MRPS10	1.33413691764991	1.55171507174296e-05
BRCA	MRPS11	MRPS12	-1.59537235222597	1.66215672512325e-20
LUAD	MRPS11	MRPS5	-2.20881945885927	1.77904381378076e-06
LUSC	MRPS11	MRPS9	-3.60637641031661	1.82498668910368e-07
LUSC	MRPS11	MRPS2	-2.70930846488508	1.92864354932136e-09
KICH	MRPS11	MRPS35	1.14233082673341	1.96695327758789e-06
LUAD	MRPS11	MRPS9	-1.32894454884901	1.98978698949574e-05
LIHC	MRPS11	MRPS12	2.67189430810317	2.56696988045444e-05
KICH	MRPS11	MRPS12	1.48941080926405	3.19480895996094e-05
KIRC	MRPS11	MRPS35	-2.33452405563859	3.58581186640388e-10
LUAD	MRPS11	MRPS14	-3.02634914022647	4.24616078981701e-06
LIHC	MRPS11	MRPS2	-1.14771055358828	4.2584580238307e-05
LUSC	MRPS11	MRPS5	-7.65956389962319	4.27210217182982e-06
LUSC	MRPS11	MRPS14	-3.86726163364221	6.1453992201761e-05
BRCA	MRPS11	MRPS7	-2.12787460270434	9.33194208595055e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPS11

ICT1, CUL3, COPS5, MRPS14, SAMM50, RPS23, RPL23, RPL9, RPS26, SRPK1, CEP57, CEP76, NOL12, TRA2A, RPL6, MRPS2, ZC3H3, RPS8, TRMT10B, ZNF707, MRPS31, MRPS5, MRPS9, CUL4A, PTCD3, MTIF2, DCAF5, MRPS22, WDTC1, DDA1, PCMTD1, PCMTD2, MRPS18C, RPS2, DAP3, Fbxo21, CDC14B, DUSP11, NOA1, TNIK, MRPS15, DRAP1, MRPS34, STRBP, SUPV3L1, MRPS27, MRPS21, MRPS35, RBM12, MRPS33, MLLT4, EDC4, AURKAIP1, MRPS7, TPD52, FNTB, ZC3H4, NAA16, MRPS18B, TCEA1, RCBTB2, MRPS26, NAA15, LETM1, RPRD1A, ZBTB48, PSMF1, MRPS25, DBT, MRPS24, DDX55, ETF1, CYB5R3, MRPS28, E4F1, HNRNPR, ZFC3H1, CUL4B, ZNF331, MCAT, MRPS23, ZNF324B, ZNF169, PUS1, MRPS10, SRP54, DLST, TRIM25, ACTL6A, ATP1A1, FAM50A, GINS4, KIF14, MED14, MRPL57, MRPL10, MRPL22, MRPL43, GATB, PGD, PGK1, PSMB6, PSMC6, TAF2, WDR61, ESR2, HEXIM1, MEPCE, LARP7, RECQL4, MRM1, HSPD1, PDK1, TRMT61B, RC3H2, NR2C2, KRAS, TCF7L2, SNRNP70, NAA10, HTRA2, PARL, nsp13, nsp3, nsp9, ORF10, ORF14, ORF8, IMMP2L, ACAD9, AUH, C12orf65, C1QBP, C21orf33, C6orf203, FASTKD2, FASTKD3, FASTKD5, GFM1, GRSF1, HINT2, LRPPRC, MDH2, METTL15, METTL17, MRPL11, MRRF, MTERF3, MTFMT, MTG2, MTIF3, MTRF1, MTRF1L, SLIRP, SSBP1, TACO1, TBRG4, TFAM, TRUB2, TSFM, TUFM, EXD2, CLPP, INS, MAFB, HSCB, CCNT1, CIAO1, NSRP1, LRPAP1, CPSF2, C1orf35, AARS2, COX8A, CS, EBAG9, PDHA1, MAP4K3, ZBTB2, IGF2BP3, SRSF5, HNRNPU, SRSF3, PRR3, YBX1, H1FNT, RPL26, LIN28B, ZNF460, YBX2, CRYBB1, RBMS2, ZKSCAN8, RPL17, MRPS17, GLI4, SURF6, RBM47, HIST1H2AM, SRSF7, RPL35, RPL4, NEIL1, SRP14, MRPS16, APOBEC3D, UBR2, ABT1, RPL36AL, MRPL2, NAAA, ERAL1, MRPS6, RPLP0, RPL10, SRSF1, RPL19, KRT31, PRPF6, NRP1, CLEC4E, M, NBR1, SQSTM1, KLF12, KLF4,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPS11	BRCA	chr15	89020219	89020219	G	A	Splice_Site	e5-1	3
MRPS11	BRCA	chr15	89020270	89020270	G	A	Silent	p.L154	3
MRPS11	UCS	chr15	89021195	89021195	G	A	Silent	p.K190K	3
MRPS11	PAAD	chr15	89018411	89018411	C	T	Missense_Mutation	p.R118W	3
MRPS11	UCEC	chr15	89018470	89018470	G	A	Silent	p.A137	2
MRPS11	HNSC	chr15	89015921	89015921	G	A	Silent	p.E82E	2
MRPS11	UCEC	chr15	89020250	89020250	C	T	Nonsense_Mutation	p.R148*	2
MRPS11	UCEC	chr15	89021168	89021168	C	A	Silent	p.I181	2
MRPS11	SKCM	chr15	89015874	89015874	C	T	Missense_Mutation	p.P67S	2
MRPS11	COAD	chr15	89021115	89021115	G	A	Missense_Mutation	p.G164R	2
MRPS11	LIHC	chr15	89010963	89010963	A	-	Frame_Shift_Del	p.R5fs	2
MRPS11	SKCM	chr15	89015862	89015862	T	A	Missense_Mutation	p.Y63N	2
MRPS11	STAD	chr15	89020237	89020237	C	T	Silent	p.G143G	2
MRPS11	ESCA	chr15	89018446	89018446	G	A	Silent		2
MRPS11	PAAD	chr15	89018411	89018411	C	T	Missense_Mutation		2
MRPS11	ESCA	chr15	89018446	89018446	G	A	Silent	p.Q129Q	2
MRPS11	UCEC	chr15	89018364	89018364	C	A	Missense_Mutation	p.A102D	2
MRPS11	HNSC	chr15	89015921	89015921	G	A	Silent		1
MRPS11	SARC	chr15	89011240	89011240	G	T	Missense_Mutation		1
MRPS11	SARC	chr15	89020273	89020273	G	T	Silent		1
MRPS11	KIRP	chr15	89011141	89011141	G	T	Missense_Mutation		1
MRPS11	SARC	chr15	89010807	89010807	G	T	Missense_Mutation		1
MRPS11	COAD	chr15	89015858	89015858	C	T	Silent	p.S61S	1
MRPS11	LIHC	chr15	89021126	89021126	G	-	Frame_Shift_Del	p.M167fs	1
MRPS11	UCS	chr15	89021195	89021195	G	A	Silent		1
MRPS11	COAD	chr15	89018438	89018438	G	A	Missense_Mutation	p.A127T	1
MRPS11	LIHC	chr15	89015913	89015913	T	-	Frame_Shift_Del	p.F80fs	1
MRPS11	ESCA	chr15	89018446	89018446	G	A	Missense_Mutation	p.D109N	1
MRPS11	LIHC	chr15	89021145	89021145	T	C	Missense_Mutation		1
MRPS11	STAD	chr15	89020277	89020277	G	T	Nonsense_Mutation	p.G157*	1
MRPS11	ESCA	chr15	89018469	89018469	C	A	Missense_Mutation	p.A137E	1
MRPS11	LUAD	chr15	89015892	89015892	C	G	Missense_Mutation	p.L73V	1
MRPS11	STAD	chr15	89010975	89010975	G	A	Silent	p.S9S	1
MRPS11	ESCA	chr15	89018469	89018469	C	A	Missense_Mutation		1
MRPS11	LUAD	chr15	89011140	89011140	A	T	Splice_Site	p.R23_splice	1
MRPS11	TGCT	chr15	89010689	89010689	C	T	Missense_Mutation		1
MRPS11	TGCT	chr15	89010976	89010976	C	T	Missense_Mutation		1

Copy number variation (CNV) of MRPS11
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPS11
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
24625	PRAD	TCGA-G9-6354	DYNC1LI1	chr3	32582528	-	MRPS11	chr15	89020219	+
24625	PRAD	TCGA-G9-6354-01A	DYNC1LI1	chr3	32582529	-	MRPS11	chr15	89020220	+
91359	N/A	BD309467	MRPS11	chr15	89021618	+	CACNB2	chr10	18493898	+
89093	N/A	AF320777	MRPS11	chr15	89021498	+	LYST	chr1	235961871	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	MRPS11	0.0345713245642587	0.97
LUAD	MRPS11	0.0367538743897393	0.99
LIHC	MRPS11	0.0449458882985729	1
SKCM	MRPS11	0.0488995079178209	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	MRPS11	0.0459479089077778	1
LGG	MRPS11	0.00186077236759269	0.061
CESC	MRPS11	0.0214239515060968	0.69
THYM	MRPS11	0.0273967265825723	0.85

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0024623	Malignant neoplasm of stomach	1	CTD_human
C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human