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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: MRPS6 (NCBI Gene ID:64968)


Gene Summary

check button Gene Summary
Gene InformationGene Name: MRPS6
Gene ID: 64968
Gene Symbol

MRPS6

Gene ID

64968

Gene Namemitochondrial ribosomal protein S6
SynonymsC21orf101|MRP-S6|RPMS6|S6mt
Cytomap

21q22.11

Type of Geneprotein-coding
Description28S ribosomal protein S6, mitochondrialmitochondrial small ribosomal subunit protein bS6m
Modification date20200313
UniProtAcc

P82932


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0032543Mitochondrial translation
GO:0005840Ribosome
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPS6>1119.25


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Translation Studies in PubMed

check button We searched PubMed using 'MRPS6[title] AND translation [title] AND human.'
GeneTitlePMID
MRPS6..


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.


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Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
all structure

check buttonExpression level of gene isoforms across TCGA pancancer
all structure

check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
all structure

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
CHOLMRPS62.570973924099390.0078125
LUSCMRPS6-1.261588108392590.013873001943322
PRADMRPS61.006732309651643.48152859299693e-07
KIRCMRPS6-3.126219337436634.95376546353503e-10
KICHMRPS6-1.343762319222767.49826431274414e-05


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through copy number variation of Translation factor
all structure
Cancer typeGeneCoefficientPvalue
HNSCMRPS6-0.0958502550.000447982
PAADMRPS6-0.2394046690.007878923
THCAMRPS6-0.2308542170.030052111

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with MRPS6 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
check button
* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
COADMRPS6MRPS122.115663331148240.000125885009765625
BRCAMRPS6MRPS15-2.195675516823180.000188684660674703
KICHMRPS6MRPS51.251082878384370.000249803066253662
LIHCMRPS6MRPS71.270293954772080.00182077236082954
STADMRPS6MRPS16-1.642080849874310.00239070039242506
KIRCMRPS6MRPS151.115722838360120.00361818577801855
ESCAMRPS6MRPS12-1.862485498145060.0048828125
PRADMRPS6MRPS91.043791155532690.00496210155254694
HNSCMRPS6MRPS16-2.015646218218030.00518989327406416
KICHMRPS6MRPS21.265439895550150.0114533305168152
THCAMRPS6MRPS15-1.199606024229950.0140154883942907
ESCAMRPS6MRPS5-2.154401187478540.0185546875
ESCAMRPS6MRPS2-3.205567880846750.0244140625
HNSCMRPS6MRPS121.336771399271360.0248336488591576
LUADMRPS6MRPS12-5.33991856837191.00823612619819e-08
THCAMRPS6MRPS101.334136917649911.55171507174296e-05
BRCAMRPS6MRPS12-1.595372352225971.66215672512325e-20
LUADMRPS6MRPS5-2.208819458859271.77904381378076e-06
LUSCMRPS6MRPS9-3.606376410316611.82498668910368e-07
LUSCMRPS6MRPS2-2.709308464885081.92864354932136e-09
LUADMRPS6MRPS9-1.328944548849011.98978698949574e-05
LUADMRPS6MRPL42-6.346102496024912.48255276366547e-08
LIHCMRPS6MRPS122.671894308103172.56696988045444e-05
KICHMRPS6MRPS121.489410809264053.19480895996094e-05
LUADMRPS6MRPS14-3.026349140226474.24616078981701e-06
LIHCMRPS6MRPS2-1.147710553588284.2584580238307e-05
LUSCMRPS6MRPS5-7.659563899623194.27210217182982e-06
KIRCMRPS6MRPL42-4.3820953362485.26630854166927e-06
LUSCMRPS6MRPS14-3.867261633642216.1453992201761e-05
BRCAMRPS6MRPS7-2.127874602704349.33194208595055e-10


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with MRPS6
KIAA1377, LRIF1, SRRM2, ICT1, APP, RNF181, SREBF2, STAT5A, SRPK2, MKRN3, TRA2A, MRPS31, MRPS18C, MRPS18B, MRPL50, NANOG, CDC14B, MRPS34, MRPS15, RBM3, TRIM25, LARP7, MEPCE, RECQL4, FBL, RPS6, MRM1, HSPD1, PDK1, TRMT61B, AURKAIP1, RC3H1, RC3H2, DYNC1I2, TCF7L2, ALYREF, SNRNP70, LNX1, STAT5B, PLEKHA4, FGFR1, PRKCB, RIPK1, IMMP2L, CELF1, GRSF1, ELAVL1, MEX3B, ACAD9, AUH, C12orf65, C17orf80, C1QBP, C21orf33, C6orf203, C8orf82, MCUR1, CCDC90B, CHCHD1, COX15, CRYZ, CS, DDX28, DHX30, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, LONP1, LRPPRC, MCU, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRPS26, MRRF, MTERF3, MTFMT, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, OTC, PMPCA, PMPCB, RMND1, RPUSD3, RPUSD4, SLIRP, SSBP1, SURF1, TACO1, TBRG4, TEFM, TFAM, C19orf52, TMEM70, TRUB2, TSFM, TUFM, VWA8, EXD2, CLPP, MAFB, HSCB, DNAJC19, HSPBAP1, AARS2, PDHA1, TRAP1, FZR1, MAP4K3, PTCD3, MRPS10, MRPS9, MRPS5, MRPS25, DNAJC21, MRPS27, DAP3, NOA1, MRPS2, METTL2B, MRPS21, DBT, MRPS35, MRPS7, MCAT, MRPS24, MRPS17, TRIP12, MRPS22, SUPV3L1, DDX55, MRPS33, NDUFA9, MRPS23, PSME1, RPL10, CORO6, MRPS14, ERAL1, APOBEC3D, ZC3H3, MRPS16, ABT1, MRPS11, BTF3, ZRANB1, BSG, N, KLF12, KLF15,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
MRPS6LUADchr213551475735514757GTMissense_Mutationp.V79L3
MRPS6BLCAchr213549767035497670GASilentp.T25T2
MRPS6UCECchr213551471435514714CAMissense_Mutationp.F64L2
MRPS6COADchr213549768535497685GTMissense_Mutationp.M30I2
MRPS6SKCMchr213551481035514810CTSilentp.H96H2
MRPS6SKCMchr213551481135514811CTMissense_Mutationp.P97S2
MRPS6LUADchr213551485635514856CTMissense_Mutationp.P112S2
MRPS6STADchr213549766935497669CTMissense_Mutationp.T25M2
MRPS6BLCAchr213551479135514791GCMissense_Mutationp.R90T1
MRPS6LUADchr213551475935514759GCSilentp.V79V1
MRPS6THYMchr213551473335514733CAMissense_Mutationp.P71T1
MRPS6LUADchr213551476035514760GTNonsense_Mutationp.E80*1
MRPS6LUADchr213551473335514733CTMissense_Mutationp.P71S1
MRPS6COADchr213549777835497778CTSilentp.G61G1
MRPS6LUADchr213549777935497779GTMissense_Mutationp.G62W1
MRPS6ESCAchr213551477835514778ATMissense_Mutationp.I86L1
MRPS6LUSCchr213551472135514721GTMissense_Mutationp.D67Y1
MRPS6KIRCchr213551472335514723T-Frame_Shift_Delp.D67fs1
MRPS6OVchr213436774534367745CGMissense_Mutationp.R20G1
MRPS6LIHCchr213549766735497667TCSilentp.R24R1
MRPS6BLCAchr213551486535514865GAMissense_Mutation1
MRPS6LIHCchr213549771435497714A-Frame_Shift_Delp.E40fs1
MRPS6BLCAchr213551479135514791GCMissense_Mutation1
MRPS6BLCAchr213549767035497670GASilent1
MRPS6THCAchr213551473835514738CASilent1
MRPS6BLCAchr213551486535514865GAMissense_Mutationp.E115K1
MRPS6LUADchr213549776635497766GCMissense_Mutationp.Q57H1
MRPS6THYMchr213551473335514733CAMissense_Mutation1

check buttonCopy number variation (CNV) of MRPS6
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across MRPS6
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
101478STADTCGA-HU-A4GN-01ABACE2chr2142540502+MRPS6chr2135497641+
101478BRCATCGA-BH-A1FD-01ADYRK1Achr2138858916+MRPS6chr2135497641+
101478STADTCGA-BR-6458GLG1chr1674640554-MRPS6chr2135497640+
101478STADTCGA-BR-8295-01AIFNAR1chr2134707953+MRPS6chr2135497641+
101478CESCTCGA-C5-A1BN-01BLINC00649chr2135318199+MRPS6chr2135497641+
91832STADTCGA-CG-5717-01AMRPS6chr2135445568+CSNK1Echr2238710174-
84048BRCATCGA-D8-A1JK-01AMRPS6chr2135446045+IFNGR2chr2134787195+
101478N/ABI002237MRPS6chr2135497647-MRPS6chr2135515077-
83423HNSCTCGA-CV-6948-01AMRPS6chr2135446045+MYO3Achr1026490194+
85091N/ACS190522MRPS6chr2135470772+PMS1chr2190700697-
55229BLCATCGA-BL-A0C8-01AMRPS6chr2135497780+SLC5A3chr2135475134+
98848N/ABG991801MRPS6chr2135474464-UBXN11chr126630361-
101478N/ABI493912PDE1Achr2183337698+MRPS6chr2135478559-
101478SARCTCGA-DX-A3U7PID1chr2230020533-MRPS6chr2135497640+
101478SARCTCGA-DX-A3U7PID1chr2230020533-MRPS6chr2135514707+
101478SARCTCGA-DX-A3U7PID1chr2230135729-MRPS6chr2135497640+
101478SARCTCGA-DX-A3U7-01APID1chr2230020534-MRPS6chr2135497641+
101478Non-CancerERR315453PPARGchr312353952+MRPS6chr2135475134+
101478Non-Cancer123NdSLC5A3chr2135446045+MRPS6chr2135514707+
101478PRADTCGA-EJ-8469TMPRSS2chr2142845251-MRPS6chr2135497640+
101478PRADTCGA-EJ-8469-01ATMPRSS2chr2142845252-MRPS6chr2135497641+
101478BRCATCGA-C8-A12U-01AZNF107chr764139714+MRPS6chr2135497641+
101480STADTCGA-BR-A4PD-01AZNF133chr2018269248+MRPS6chr2135475134+


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
BLCAMRPS60.008284460534235130.22
LUADMRPS60.0151583602515260.39
LUSCMRPS60.03980163639358141
KIRCMRPS62.04943086984684e-065.7e-05

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
LGGMRPS60.0003488298261601670.011
SKCMMRPS65.48434231564115e-050.0018
UCSMRPS60.02025586725624140.63

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source
C0010054Coronary Arteriosclerosis1CTD_human
C1956346Coronary Artery Disease1CTD_human