Home

Download

Statistics

Examples

Help

Contact

	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL34 (NCBI Gene ID:64981)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL34
	Gene ID: 64981
	Gene Symbol	MRPL34
	Gene ID	64981
	Gene Name	mitochondrial ribosomal protein L34
	Synonyms	L34mt
	Cytomap	19p13.11
	Type of Gene	protein-coding
	Description	39S ribosomal protein L34, mitochondrialMRP-L34mitochondrial large ribosomal subunit protein bL34m
	Modification date	20200313
	UniProtAcc	Q9BQ48

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPL34	>1119.25

Top

Translation Studies in PubMed

We searched PubMed using 'MRPL34[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL34	.	.

Top

Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000600434	17409120	17409186	5UTR-5UTR

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

Top

Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
CHOL	MRPL34	-3.42681085163621	0.00390625
COAD	MRPL34	-1.09095783476667	0.00561287999153138
LUAD	MRPL34	1.09778378060618	0.0116026131528984
KIRP	MRPL34	-1.09884801618042	3.17529775202275e-05

Top

Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
UCEC	MRPL34	0.153773543	0.000488865
COAD	MRPL34	0.020247393	0.001338948
BLCA	MRPL34	0.053446179	0.005560329
THYM	MRPL34	0.060042053	0.010507219
SKCM	MRPL34	-0.043495804	0.04847041

Top

Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL34 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	MRPL34	QDPR	0.804999373	2.64E-11
CHOL	Cell metabolism gene	MRPL34	GRPEL1	0.807890332	1.98E-11
CHOL	Cell metabolism gene	MRPL34	ACACB	0.813811111	1.07E-11
CHOL	Cell metabolism gene	MRPL34	ACADS	0.818579025	6.47E-12
CHOL	Cell metabolism gene	MRPL34	IVD	0.82261916	4.16E-12
CHOL	IUPHAR	MRPL34	ACACB	0.813811111	1.07E-11
GBM	Cell metabolism gene	MRPL34	GPX4	0.809028218	4.39E-41
GBM	Cell metabolism gene	MRPL34	PFDN5	0.82641125	2.90E-44
GBM	IUPHAR	MRPL34	ATP6V0B	0.806318716	1.28E-40
GBM	TSG	MRPL34	GADD45GIP1	0.830892094	3.85E-45
PAAD	TF	MRPL34	PIN1	0.808673437	1.43E-43
PAAD	TSG	MRPL34	PIN1	0.808673437	1.43E-43
TGCT	TSG	MRPL34	GADD45GIP1	0.827396409	2.01E-40
THCA	Cell metabolism gene	MRPL34	CYC1	0.804236413	6.39E-131
THYM	Cell metabolism gene	MRPL34	PSMA6	0.800577569	1.85E-28
THYM	Cell metabolism gene	MRPL34	TOMM22	0.800986344	1.66E-28
THYM	Cell metabolism gene	MRPL34	SNRPB	0.801028902	1.64E-28
THYM	Cell metabolism gene	MRPL34	MED27	0.802400909	1.13E-28
THYM	Cell metabolism gene	MRPL34	POLR2J	0.802696875	1.04E-28
THYM	Cell metabolism gene	MRPL34	PSMB6	0.804257932	6.81E-29
THYM	Cell metabolism gene	MRPL34	DGUOK	0.805232514	5.21E-29
THYM	Cell metabolism gene	MRPL34	PHKG2	0.805319129	5.08E-29
THYM	Cell metabolism gene	MRPL34	PFDN2	0.806738698	3.43E-29
THYM	Cell metabolism gene	MRPL34	HSD17B10	0.808306247	2.21E-29
THYM	Cell metabolism gene	MRPL34	TAZ	0.80902572	1.81E-29
THYM	Cell metabolism gene	MRPL34	SEC61B	0.811705823	8.43E-30
THYM	Cell metabolism gene	MRPL34	EBP	0.813370133	5.22E-30
THYM	Cell metabolism gene	MRPL34	PSMB10	0.814085454	4.24E-30
THYM	Cell metabolism gene	MRPL34	PSMD4	0.816535744	2.07E-30
THYM	Cell metabolism gene	MRPL34	APRT	0.817030182	1.79E-30
THYM	Cell metabolism gene	MRPL34	TXN	0.820636427	6.07E-31
THYM	Cell metabolism gene	MRPL34	TOMM5	0.822831972	3.11E-31
THYM	Cell metabolism gene	MRPL34	COX17	0.829432541	3.92E-32
THYM	Cell metabolism gene	MRPL34	GUK1	0.831510602	2.01E-32
THYM	Cell metabolism gene	MRPL34	TIMM17B	0.831898338	1.77E-32
THYM	Cell metabolism gene	MRPL34	TBCB	0.833543257	1.03E-32
THYM	Cell metabolism gene	MRPL34	TOMM40	0.834286927	8.09E-33
THYM	Cell metabolism gene	MRPL34	LSM4	0.836482153	3.90E-33
THYM	Cell metabolism gene	MRPL34	NT5M	0.836735697	3.58E-33
THYM	Cell metabolism gene	MRPL34	SNRPG	0.840049234	1.16E-33
THYM	Cell metabolism gene	MRPL34	WBSCR22	0.841580776	6.84E-34
THYM	Cell metabolism gene	MRPL34	DECR1	0.847740438	7.68E-35
THYM	Cell metabolism gene	MRPL34	PAFAH1B3	0.84916388	4.57E-35
THYM	Cell metabolism gene	MRPL34	PSMB4	0.868115932	2.62E-38
THYM	CGC	MRPL34	COX6C	0.873433002	2.61E-39
THYM	Epifactor	MRPL34	DPY30	0.801741074	1.35E-28
THYM	Epifactor	MRPL34	ENY2	0.802517125	1.10E-28
THYM	Epifactor	MRPL34	HMG20B	0.810442538	1.21E-29
THYM	Epifactor	MRPL34	HIST2H2AC	0.831150373	2.26E-32
THYM	Epifactor	MRPL34	RBX1	0.837176697	3.08E-33
THYM	Epifactor	MRPL34	PRR14	0.845092352	1.99E-34
THYM	Epifactor	MRPL34	CDK5	0.850576794	2.72E-35
THYM	IUPHAR	MRPL34	PSMB6	0.804257932	6.81E-29
THYM	IUPHAR	MRPL34	PHKG2	0.805319129	5.08E-29
THYM	IUPHAR	MRPL34	NT5M	0.836735697	3.58E-33
THYM	IUPHAR	MRPL34	CDK5	0.850576794	2.72E-35
THYM	IUPHAR	MRPL34	PPIA	0.851853261	1.69E-35
THYM	Kinase	MRPL34	PHKG2	0.805319129	5.08E-29
THYM	Kinase	MRPL34	CDK5	0.850576794	2.72E-35
THYM	TF	MRPL34	SNAPC2	0.802032809	1.25E-28
THYM	TF	MRPL34	GLI4	0.806435557	3.73E-29
THYM	TF	MRPL34	GTF3A	0.809480525	1.59E-29
THYM	TF	MRPL34	HMG20B	0.810442538	1.21E-29
THYM	TF	MRPL34	USF1	0.818087988	1.30E-30
THYM	TF	MRPL34	ZNF688	0.820409973	6.50E-31
THYM	TF	MRPL34	THAP8	0.820544446	6.24E-31
THYM	TF	MRPL34	DRAP1	0.849151717	4.59E-35
THYM	TF	MRPL34	MYPOP	0.886206664	6.54E-42
UCS	Cell metabolism gene	MRPL34	PSMA6	0.800577569	1.85E-28
UCS	Cell metabolism gene	MRPL34	TOMM22	0.800986344	1.66E-28
UCS	Cell metabolism gene	MRPL34	SNRPB	0.801028902	1.64E-28
UCS	Cell metabolism gene	MRPL34	MED27	0.802400909	1.13E-28
UCS	Cell metabolism gene	MRPL34	POLR2J	0.802696875	1.04E-28
UCS	Cell metabolism gene	MRPL34	PSMB6	0.804257932	6.81E-29
UCS	Cell metabolism gene	MRPL34	DGUOK	0.805232514	5.21E-29
UCS	Cell metabolism gene	MRPL34	PHKG2	0.805319129	5.08E-29
UCS	Cell metabolism gene	MRPL34	PFDN2	0.806738698	3.43E-29
UCS	Cell metabolism gene	MRPL34	HSD17B10	0.808306247	2.21E-29
UCS	Cell metabolism gene	MRPL34	TAZ	0.80902572	1.81E-29
UCS	Cell metabolism gene	MRPL34	SEC61B	0.811705823	8.43E-30
UCS	Cell metabolism gene	MRPL34	EBP	0.813370133	5.22E-30
UCS	Cell metabolism gene	MRPL34	PSMB10	0.814085454	4.24E-30
UCS	Cell metabolism gene	MRPL34	PSMD4	0.816535744	2.07E-30
UCS	Cell metabolism gene	MRPL34	APRT	0.817030182	1.79E-30
UCS	Cell metabolism gene	MRPL34	TXN	0.820636427	6.07E-31
UCS	Cell metabolism gene	MRPL34	TOMM5	0.822831972	3.11E-31
UCS	Cell metabolism gene	MRPL34	COX17	0.829432541	3.92E-32
UCS	Cell metabolism gene	MRPL34	GUK1	0.831510602	2.01E-32
UCS	Cell metabolism gene	MRPL34	TIMM17B	0.831898338	1.77E-32
UCS	Cell metabolism gene	MRPL34	TBCB	0.833543257	1.03E-32
UCS	Cell metabolism gene	MRPL34	TOMM40	0.834286927	8.09E-33
UCS	Cell metabolism gene	MRPL34	LSM4	0.836482153	3.90E-33
UCS	Cell metabolism gene	MRPL34	NT5M	0.836735697	3.58E-33
UCS	Cell metabolism gene	MRPL34	SNRPG	0.840049234	1.16E-33
UCS	Cell metabolism gene	MRPL34	WBSCR22	0.841580776	6.84E-34
UCS	Cell metabolism gene	MRPL34	DECR1	0.847740438	7.68E-35
UCS	Cell metabolism gene	MRPL34	PAFAH1B3	0.84916388	4.57E-35
UCS	Cell metabolism gene	MRPL34	PSMB4	0.868115932	2.62E-38
UCS	CGC	MRPL34	COX6C	0.873433002	2.61E-39
UCS	Epifactor	MRPL34	DPY30	0.801741074	1.35E-28
UCS	Epifactor	MRPL34	ENY2	0.802517125	1.10E-28
UCS	Epifactor	MRPL34	HMG20B	0.810442538	1.21E-29
UCS	Epifactor	MRPL34	HIST2H2AC	0.831150373	2.26E-32
UCS	Epifactor	MRPL34	RBX1	0.837176697	3.08E-33
UCS	Epifactor	MRPL34	PRR14	0.845092352	1.99E-34
UCS	Epifactor	MRPL34	CDK5	0.850576794	2.72E-35
UCS	IUPHAR	MRPL34	PSMB6	0.804257932	6.81E-29
UCS	IUPHAR	MRPL34	PHKG2	0.805319129	5.08E-29
UCS	IUPHAR	MRPL34	NT5M	0.836735697	3.58E-33
UCS	IUPHAR	MRPL34	CDK5	0.850576794	2.72E-35
UCS	IUPHAR	MRPL34	PPIA	0.851853261	1.69E-35
UCS	Kinase	MRPL34	PHKG2	0.805319129	5.08E-29
UCS	Kinase	MRPL34	CDK5	0.850576794	2.72E-35
UCS	TF	MRPL34	SNAPC2	0.802032809	1.25E-28
UCS	TF	MRPL34	GLI4	0.806435557	3.73E-29
UCS	TF	MRPL34	GTF3A	0.809480525	1.59E-29
UCS	TF	MRPL34	HMG20B	0.810442538	1.21E-29
UCS	TF	MRPL34	USF1	0.818087988	1.30E-30
UCS	TF	MRPL34	ZNF688	0.820409973	6.50E-31
UCS	TF	MRPL34	THAP8	0.820544446	6.24E-31
UCS	TF	MRPL34	DRAP1	0.849151717	4.59E-35
UCS	TF	MRPL34	MYPOP	0.886206664	6.54E-42

Top

Protein structure

Protein 3D structure
Visit iCn3D.

Top

Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRC	MRPL34	MRPL46	-7.36081421944909	0.0011460554764592
KIRP	MRPL34	MRPL46	-7.17671685013906	0.00123529229313135
COAD	MRPL34	MRPL41	-2.99561502382389	0.00144392251968384
KIRP	MRPL34	MRPL19	-1.9689242575519	0.00179363833740354
ESCA	MRPL34	MRPL47	-2.26373711796715	0.001953125
CHOL	MRPL34	MRPL2	-1.49926301466752	0.00390625
CHOL	MRPL34	MRPL3	-2.68429255990621	0.00390625
CHOL	MRPL34	MRPL41	-4.96379377542225	0.00390625
CHOL	MRPL34	MRPL46	-2.73791743817321	0.00390625
ESCA	MRPL34	MRPL3	-4.97897094908275	0.0048828125
THCA	MRPL34	MRPL41	-3.88188543554269	0.00492925389458784
KICH	MRPL34	MRPL19	-2.18550705564541	0.00672554969787598
COAD	MRPL34	MRPL47	-2.29582381838246	0.00863465666770936
ESCA	MRPL34	MRPL17	-1.18756178214998	0.009765625
STAD	MRPL34	MRPL47	-1.4008685687155	0.0118026207201183
LIHC	MRPL34	MRPL17	-1.06225729770915	0.0124123499319886
STAD	MRPL34	MRPL4	1.4393539135682	0.0279771662317216
CHOL	MRPL34	MRPL19	-2.09295650388558	0.0390625
LIHC	MRPL34	MRPL47	-6.59586850948538	0.0416658979324166
BLCA	MRPL34	MRPL2	-3.29210657477178	0.0445594787597656
KIRC	MRPL34	MRPL47	1.74758475364701	1.00533732476669e-06
LUAD	MRPL34	MRPL2	-1.26727646741024	1.07341296213058e-06
STAD	MRPL34	MRPL17	-3.90880705449186	1.49570405483246e-06
KIRP	MRPL34	MRPL49	-2.36524030474784	1.53668224811554e-08
KIRC	MRPL34	MRPL3	1.69955762234244	1.97132191719422e-08
COAD	MRPL34	MRPL4	2.77705897514473	2.98023223876954e-07
PRAD	MRPL34	MRPL41	1.31179686307216	4.41809300064344e-05
THCA	MRPL34	MRPL49	-1.28871899028168	5.42468304941934e-06
LUSC	MRPL34	MRPL17	-6.83409683292749	6.93230040561614e-07
LUSC	MRPL34	MRPL2	-2.66710222706783	7.24218086307245e-08
KICH	MRPL34	MRPL41	1.05103651319563	7.49826431274414e-05
LUAD	MRPL34	MRPL47	-1.74990909879567	9.53955602455483e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL34

APP, RPL13, MRPL28, TRA2A, RPL6, ZC3H3, RPS8, MRPL4, MRPL39, MRPS30, MRPL47, MRPL50, MRPL9, MRPL1, RANBP6, IPO5, RAP1A, UTP11L, MRPL10, RPL38, C8orf59, HBZ, C19orf53, MRPL41, MRPL35, H2AFY2, CSNK1G3, MRPL42, SLC27A2, KBTBD7, vIRF-4, TNIP2, nsp13, ORF10, C12orf65, C6orf203, ICT1, USP15, MRPL13, H1FNT, MRPL18, MRPL53, MRPL30, MRPL2, RPL19, MRPL52, GADD45GIP1, MRPL12, MRPL37, MRPL27, TMEM192,

Top

Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene

Cancer type

Chromosome

Start

End

RefSeeq

MutSeq

Mutation type

AAchange

# samples

Copy number variation (CNV) of MRPL34
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL34
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
95222	N/A	CA495342	ABHD8	chr19	17403663	+	MRPL34	chr19	17416640	+
95231	N/A	Z19494	TTN	chr2	179554605	+	MRPL34	chr19	17417464	-

Top

Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

Top

Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	MRPL34	0.000981805708003528	0.027
MESO	MRPL34	0.0368739525893817	1

Top

Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	MRPL34	0.000239806739459859	0.0079
THCA	MRPL34	0.00260037244616113	0.083
LGG	MRPL34	0.0134994646762388	0.39
UVM	MRPL34	0.0153607559782232	0.43
UCEC	MRPL34	0.011511424174705	0.35
THYM	MRPL34	0.0106753385987271	0.33

Top

Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source