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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL32 (NCBI Gene ID:64983)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL32
	Gene ID: 64983
	Gene Symbol	MRPL32
	Gene ID	64983
	Gene Name	mitochondrial ribosomal protein L32
	Synonyms	HSPC283\|L32mt\|MRP-L32\|bMRP-59b
	Cytomap	7p14.1
	Type of Gene	protein-coding
	Description	39S ribosomal protein L32, mitochondrialmitochondrial large ribosomal subunit protein bL32m
	Modification date	20200313
	UniProtAcc	Q9BYC8

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPL32[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL32	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BRCA	MRPL32	-3.7979134181794	0.000134327661287861
LUAD	MRPL32	-2.1966239418264	0.00121089428940613
KIRC	MRPL32	-2.79664327578899	0.0376051795400881
LIHC	MRPL32	-1.20074144698753	2.24402029682138e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
PRAD	MRPL32	2	1	0.0205428241459175	0.212191458116093	0.173549229188078	0.14813951095162	0.0960345852571211
SARC	MRPL32	2	1	0.00584622458330139	0.206882467532468	0.162750913621262	0.633442629731391	0.232909965883093

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
READ	MRPL32	2	1	0.0148725454681515	0.268565489130435	0.179397321428571	0.140151366604967	-0.263105465693464

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LIHC	MRPL32	0.114091537	0.003977368

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL32 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	MRPL32	ACAA1	0.801247997	3.82E-11
CHOL	Cell metabolism gene	MRPL32	GOT2	0.802702885	3.31E-11
CHOL	Cell metabolism gene	MRPL32	ADI1	0.80280521	3.28E-11
CHOL	Cell metabolism gene	MRPL32	GSTK1	0.80392129	2.94E-11
CHOL	Cell metabolism gene	MRPL32	IVD	0.803956454	2.93E-11
CHOL	Cell metabolism gene	MRPL32	PEMT	0.804662355	2.73E-11
CHOL	Cell metabolism gene	MRPL32	AFMID	0.806233247	2.34E-11
CHOL	Cell metabolism gene	MRPL32	ALAS1	0.808250188	1.91E-11
CHOL	Cell metabolism gene	MRPL32	DECR1	0.810748285	1.48E-11
CHOL	Cell metabolism gene	MRPL32	CAT	0.811034417	1.43E-11
CHOL	Cell metabolism gene	MRPL32	PMPCA	0.814227192	1.03E-11
CHOL	Cell metabolism gene	MRPL32	HIBADH	0.814340771	1.02E-11
CHOL	Cell metabolism gene	MRPL32	SDHB	0.818310675	6.66E-12
CHOL	Cell metabolism gene	MRPL32	HAGH	0.820761761	5.11E-12
CHOL	Cell metabolism gene	MRPL32	GRHPR	0.823683195	3.70E-12
CHOL	Cell metabolism gene	MRPL32	GLYCTK	0.826467933	2.71E-12
CHOL	Cell metabolism gene	MRPL32	HADH	0.827751488	2.34E-12
CHOL	Cell metabolism gene	MRPL32	GLUD1	0.827809774	2.32E-12
CHOL	Cell metabolism gene	MRPL32	ASL	0.829224532	1.98E-12
CHOL	Cell metabolism gene	MRPL32	PSMA2	0.830329112	1.74E-12
CHOL	Cell metabolism gene	MRPL32	ACADS	0.83486588	1.02E-12
CHOL	Cell metabolism gene	MRPL32	QDPR	0.842495714	3.99E-13
CHOL	Cell metabolism gene	MRPL32	HMGCL	0.848050711	1.96E-13
CHOL	Cell metabolism gene	MRPL32	ECHS1	0.853000308	1.01E-13
CHOL	Cell metabolism gene	MRPL32	SUCLG2	0.853724238	9.16E-14
CHOL	Cell metabolism gene	MRPL32	EBP	0.8593816	4.16E-14
CHOL	CGC	MRPL32	SDHB	0.818310675	6.66E-12
CHOL	IUPHAR	MRPL32	CAT	0.811034417	1.43E-11
CHOL	TSG	MRPL32	PEBP1	0.80294648	3.24E-11
CHOL	TSG	MRPL32	CAT	0.811034417	1.43E-11
CHOL	TSG	MRPL32	SDHB	0.818310675	6.66E-12
COAD	Cell metabolism gene	MRPL32	LSM5	0.802740263	2.10E-75
COAD	Cell metabolism gene	MRPL32	PSMA2	0.837987001	5.03E-88
COAD	IUPHAR	MRPL32	PPIA	0.830729944	3.44E-85
GBM	Cell metabolism gene	MRPL32	PSMA2	0.849941052	3.52E-49
LUAD	Cell metabolism gene	MRPL32	PSMA2	0.814788384	5.18E-138
LUSC	Cell metabolism gene	MRPL32	PSMA2	0.838410604	2.39E-147
LUSC	IUPHAR	MRPL32	PPIA	0.803684938	2.55E-126
OV	Cell metabolism gene	MRPL32	PSMA2	0.83830727	1.32E-82
SKCM	Cell metabolism gene	MRPL32	PSMA2	0.802347959	7.42E-108
STAD	Cell metabolism gene	MRPL32	PSMA2	0.827208116	3.19E-114
TGCT	Cell metabolism gene	MRPL32	CCT6A	0.822966895	1.18E-39
UVM	Cell metabolism gene	MRPL32	SRP19	0.800132291	5.42E-19
UVM	Cell metabolism gene	MRPL32	MED7	0.805909718	1.94E-19
UVM	Cell metabolism gene	MRPL32	GRPEL2	0.809992313	9.22E-20
UVM	Cell metabolism gene	MRPL32	CNOT8	0.81356138	4.73E-20
UVM	Cell metabolism gene	MRPL32	PSMD14	0.833519363	8.56E-22
UVM	Cell metabolism gene	MRPL32	NUP107	0.835109449	6.08E-22
UVM	Cell metabolism gene	MRPL32	CCT2	0.840327923	1.93E-22
UVM	Cell metabolism gene	MRPL32	PSMA2	0.847115538	4.05E-23
UVM	Cell metabolism gene	MRPL32	PSMC6	0.857877481	2.92E-24
UVM	Cell metabolism gene	MRPL32	NUPL2	0.86895055	1.53E-25
UVM	CGC	MRPL32	PMS1	0.812372946	5.92E-20
UVM	Epifactor	MRPL32	YEATS4	0.801162106	4.53E-19
UVM	Epifactor	MRPL32	HMGB1	0.802568428	3.53E-19
UVM	Epifactor	MRPL32	GATAD1	0.803968281	2.75E-19
UVM	Epifactor	MRPL32	TAF9	0.804859764	2.35E-19
UVM	Epifactor	MRPL32	NSL1	0.807832105	1.37E-19
UVM	Epifactor	MRPL32	DNAJC2	0.809286208	1.05E-19
UVM	Epifactor	MRPL32	ACTR6	0.812811307	5.45E-20
UVM	Epifactor	MRPL32	RAD54B	0.81712111	2.40E-20
UVM	Epifactor	MRPL32	MASTL	0.820915627	1.14E-20
UVM	Epifactor	MRPL32	TAF7	0.821502726	1.02E-20
UVM	Epifactor	MRPL32	CUL2	0.83757017	3.55E-22
UVM	Epifactor	MRPL32	VRK1	0.853974482	7.76E-24
UVM	Epifactor	MRPL32	CBX3	0.875996984	2.04E-26
UVM	IUPHAR	MRPL32	MASTL	0.820915627	1.14E-20
UVM	IUPHAR	MRPL32	RIOK2	0.832431911	1.08E-21
UVM	IUPHAR	MRPL32	PSMD14	0.833519363	8.56E-22
UVM	IUPHAR	MRPL32	VRK1	0.853974482	7.76E-24
UVM	Kinase	MRPL32	MASTL	0.820915627	1.14E-20
UVM	Kinase	MRPL32	RIOK2	0.832431911	1.08E-21
UVM	Kinase	MRPL32	VRK1	0.853974482	7.76E-24
UVM	TF	MRPL32	ZNF302	0.80005093	5.50E-19
UVM	TF	MRPL32	ZNF33A	0.800172451	5.38E-19
UVM	TF	MRPL32	ZNF75D	0.800963183	4.69E-19
UVM	TF	MRPL32	ZNF383	0.802744203	3.42E-19
UVM	TF	MRPL32	ZNF92	0.804740335	2.40E-19
UVM	TF	MRPL32	RBAK	0.805620795	2.05E-19
UVM	TF	MRPL32	ZBTB1	0.806941824	1.61E-19
UVM	TF	MRPL32	IKZF5	0.811109536	7.49E-20
UVM	TF	MRPL32	THAP9	0.82324973	7.19E-21
UVM	TF	MRPL32	ZNF140	0.860791592	1.38E-24
UVM	TSG	MRPL32	PTPN2	0.823081522	7.43E-21
UVM	TSG	MRPL32	CUL2	0.83757017	3.55E-22
UVM	TSG	MRPL32	RINT1	0.848513388	2.91E-23

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	MRPL32	MRPL9	1.16888038960038	0.000120222568511963
STAD	MRPL32	MRPL15	-2.15546608137429	0.000334546435624361
LIHC	MRPL32	MRPL13	1.54402472107614	0.000655351190157038
KIRP	MRPL32	MRPL19	-1.9689242575519	0.00179363833740354
BLCA	MRPL32	MRPL27	-4.19270554058168	0.00202178955078125
CHOL	MRPL32	MRPL2	-1.49926301466752	0.00390625
COAD	MRPL32	MRPL15	1.17181689924568	0.00513318181037904
KICH	MRPL32	MRPL19	-2.18550705564541	0.00672554969787598
ESCA	MRPL32	MRPL13	-1.07746088474995	0.0068359375
ESCA	MRPL32	MRPL17	-1.18756178214998	0.009765625
STAD	MRPL32	MRPL9	-1.54523483458273	0.0118026207201183
LIHC	MRPL32	MRPL17	-1.06225729770915	0.0124123499319886
STAD	MRPL32	MRPL4	1.4393539135682	0.0279771662317216
CHOL	MRPL32	MRPL19	-2.09295650388558	0.0390625
BLCA	MRPL32	MRPL2	-3.29210657477178	0.0445594787597656
LUAD	MRPL32	MRPL2	-1.26727646741024	1.07341296213058e-06
BRCA	MRPL32	MRPL27	-1.5584165725499	1.16393956539382e-08
KICH	MRPL32	MRPL15	1.54522142310359	1.19209289550781e-07
LUSC	MRPL32	MRPL21	-4.98277643789037	1.45947399043856e-08
STAD	MRPL32	MRPL17	-3.90880705449186	1.49570405483246e-06
LUSC	MRPL32	MRPL15	-4.43702988385305	1.91594862886626e-08
COAD	MRPL32	MRPL4	2.77705897514473	2.98023223876954e-07
LUSC	MRPL32	MRPL40	-8.45997214407498	3.09303724812157e-05
LUAD	MRPL32	MRPL27	-1.39404329671842	3.44055922076328e-05
LUSC	MRPL32	MRPL27	-1.81809468729316	3.90393047420304e-06
BRCA	MRPL32	MRPL15	-3.82448964360727	5.49451113259074e-14
LUAD	MRPL32	MRPL21	-1.86897497221853	6.16191557420719e-07
LUSC	MRPL32	MRPL17	-6.83409683292749	6.93230040561614e-07
LUSC	MRPL32	MRPL2	-2.66710222706783	7.24218086307245e-08
BRCA	MRPL32	MRPL21	-1.5345447607194	7.40794680786486e-08

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL32

ICT1, MRPL44, MRPL50, MRPL37, MRPS9, MRPS28, MRPL15, MRPL39, MRPL42, MRPL21, MRPL55, MRPL40, MRPS26, MRPL11, MRPL52, MRPL28, MRPL45, MRPL38, MRPL9, FUBP1, MPV17, MRPL57, TSR1, ILF3, DDX28, ERGIC1, TIMM17B, SCFD1, RPL13, TRA2A, HNRNPDL, ZC3H3, RPS8, MRPL4, HNRNPA1, MRPS30, MRPL47, MRPL18, MRPL2, STOML2, MRPL1, C6orf203, MRPL10, MRPL41, MRPL12, RPL18, RRS1, vIRF-4, CCNK, DHODH, EIF4G1, LARS, LEO1, MRPS5, TBCB, TIMELESS, TUBB, CETN3, MEPCE, LARP7, MRM1, PDK1, TRMT61B, PRDM14, PXN, SH3GL3, AUH, C12orf65, C21orf33, METTL17, MRRF, MTIF2, NGRN, PMPCA, PMPCB, TRUB2, TSFM, HNRNPU, ZNF485, SRSF3, YBX2, LIN28A, RPL17, RPL37, YBX1, RBMS2, RPL3, FAM120A, H1FNT, RPL13A, MRPL51, SRSF5, RPL27A, GNL3, MRPL23, MRPL53, MRPL30, ZNF467, MRPL13, RPL23AP32, REXO4, RPL19, RPL26, IGF2BP3, LIN28B, MALSU1, SRSF4, RPL6, SRSF6, RPL35, RPL23A, GADD45GIP1, SRSF7, ZNF346, RBMS3, ZNF574, PRR3, MRPL46, MRPL27, MRPS18A, NEIL1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPL32	COAD	chr7	42974677	42974677	G	A	Missense_Mutation	p.R85H	5
MRPL32	ESCA	chr7	42977165	42977165	C	T	Missense_Mutation	p.T186I	4
MRPL32	ACC	chr7	42971992	42971992	C	T	Silent	p.L3L	3
MRPL32	BRCA	chr7	42972017	42972017	C	T	Missense_Mutation	p.S11L	3
MRPL32	UCEC	chr7	42976966	42976966	C	T	Missense_Mutation	p.H120Y	2
MRPL32	UCEC	chr7	42977149	42977149	C	T	Nonsense_Mutation	p.R181*	2
MRPL32	ESCA	chr7	42976978	42976978	G	T	Missense_Mutation	p.A124S	2
MRPL32	SKCM	chr7	42977019	42977019	C	T	Silent	p.I137I	2
MRPL32	ESCA	chr7	42977165	42977165	C	T	Missense_Mutation		2
MRPL32	LUAD	chr7	42972003	42972003	G	T	Silent	p.L6L	2
MRPL32	STAD	chr7	42977040	42977040	A	T	Missense_Mutation	p.Q144H	2
MRPL32	STAD	chr7	42972066	42972066	G	A	Silent	p.L27L	2
MRPL32	UCEC	chr7	42974676	42974676	C	T	Missense_Mutation	p.R85C	2
MRPL32	LUSC	chr7	42976962	42976962	G	T	Missense_Mutation	p.Q118H	1
MRPL32	COAD	chr7	42977140	42977140	G	A	Missense_Mutation	p.D178N	1
MRPL32	HNSC	chr7	42971867	42971867	A	T	Missense_Mutation		1
MRPL32	BLCA	chr7	42974729	42974729	A	G	Silent		1
MRPL32	LUSC	chr7	42972022	42972022	T	A	Missense_Mutation	p.W13R	1
MRPL32	KIRC	chr7	42977150	42977150	G	A	Missense_Mutation	p.R181Q	1
MRPL32	BLCA	chr7	42977134	42977134	G	A	Missense_Mutation		1
MRPL32	READ	chr7	42972035	42972035	G	C	Missense_Mutation	p.R17P	1
MRPL32	DLBC	chr7	42971998	42971998	A	G	Missense_Mutation	p.M5V	1
MRPL32	KIRP	chr7	42974719	42974719	A	G	Missense_Mutation	p.K99R	1
MRPL32	BLCA	chr7	42977014	42977014	G	A	Missense_Mutation	p.E136K	1
MRPL32	READ	chr7	42977022	42977022	A	G	Silent	p.R138R	1
MRPL32	LIHC	chr7	42976921	42976921	A	G	Missense_Mutation		1
MRPL32	BLCA	chr7	42974729	42974729	A	G	Silent	p.K102K	1
MRPL32	SARC	chr7	42976985	42976985	G	T	Missense_Mutation		1
MRPL32	LIHC	chr7	42976921	42976921	A	G	Missense_Mutation	p.N105D	1
MRPL32	BLCA	chr7	42977134	42977134	G	A	Missense_Mutation	p.E176K	1
MRPL32	SKCM	chr7	42977147	42977147	A	T	Missense_Mutation	p.K180M	1
MRPL32	ESCA	chr7	42976978	42976978	G	T	Missense_Mutation		1
MRPL32	LIHC	chr7	42976921	42976921	A	G	Splice_Site	p.N105_splice	1
MRPL32	ESCA	chr7	42972110	42972110	C	T	Missense_Mutation	p.P42L	1
MRPL32	LUAD	chr7	42972083	42972083	A	G	Missense_Mutation	p.Q33R	1
MRPL32	CESC	chr7	42974578	42974578	C	T	Missense_Mutation		1
MRPL32	SKCM	chr7	42972030	42972030	G	A	Silent	p.A15A	1
MRPL32	COAD	chr7	42972091	42972091	C	T	Missense_Mutation	p.P36S	1
MRPL32	GBM	chr7	42974713	42974713	C	T	Missense_Mutation	p.P97L	1
MRPL32	LUSC	chr7	42972006	42972006	C	G	Silent	p.V7V	1
MRPL32	COAD	chr7	42977091	42977091	G	A	Silent	p.T161T	1
MRPL32	GBM	chr7	42977023	42977023	C	T	Nonsense_Mutation	p.R139*	1
MRPL32	LUSC	chr7	42977163	42977163	C	T	Silent	p.F185F	1
MRPL32	COAD	chr7	42977103	42977103	G	A	Silent	p.P165P	1
MRPL32	GBM	chr7	42977023	42977023	C	T	Nonsense_Mutation		1

Copy number variation (CNV) of MRPL32
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL32
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3971	N/A	BQ437667	ALDOA	chr16	30081223	-	MRPL32	chr7	42971975	+
102808	STAD	TCGA-BR-7959-01A	MRPL32	chr7	42972115	-	C7orf72	chr7	50143910	+
57719	N/A	BM144784	MRPL32	chr7	42977110	-	PTPRE	chr10	129868105	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	MRPL32	0.000795521048822124	0.022
TGCT	MRPL32	0.00340078082729942	0.092
LAML	MRPL32	0.0333227305866701	0.87

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	MRPL32	0.00589463668804152	0.19
KIRC	MRPL32	0.0484302011233131	1
LGG	MRPL32	0.000989266709722267	0.033

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source