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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: EIF3CL (NCBI Gene ID:728689)


Gene Summary

check button Gene Summary
Gene InformationGene Name: EIF3CL
Gene ID: 728689
Gene Symbol

EIF3CL

Gene ID

728689

Gene Nameeukaryotic translation initiation factor 3 subunit C like
Synonyms-
Cytomap

16p12.1

Type of Geneprotein-coding
Descriptioneukaryotic translation initiation factor 3 subunit C-like proteineIF3 p110eukaryotic translation initiation factor 3 subunit 8eukaryotic translation initiation factor 3, subunit 8, 110kDa-like
Modification date20200313
UniProtAcc

B5ME19


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0006417Regulation of translation
GO:0008135Translation factor activity, RNA binding
GO:0002181Cytoplasmic translation
GO:0006413Translational initiation
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EIF3CL>1119.25


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Translation Studies in PubMed

check button We searched PubMed using 'EIF3CL[title] AND translation [title] AND human.'
GeneTitlePMID
EIF3CL..


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF
ENST000003808762839443828394802Frame-shift
ENST000003989442839443828394802Frame-shift
ENST000003808762840184028401966In-frame
ENST000003989442840184028401966In-frame
ENST000003808762840330028403463Frame-shift
ENST000003989442840330028403463Frame-shift
ENST000003808762841217928412305In-frame
ENST000003989442841217928412305In-frame
ENST000003808762841252728412717Frame-shift
ENST000003989442841252728412717Frame-shift

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)
ENST000003989442840184028401966307012751400914395437
ENST000003808762840184028401966310213091434914395437
ENST0000039894428412179284123053070447572914119161
ENST0000038087628412179284123053102481606914119161

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.
B5ME191191611914ChainID=PRO_0000422825;Note=Eukaryotic translation initiation factor 3 subunit C-like protein
B5ME193954371914ChainID=PRO_0000422825;Note=Eukaryotic translation initiation factor 3 subunit C-like protein
B5ME191191611914ChainID=PRO_0000422825;Note=Eukaryotic translation initiation factor 3 subunit C-like protein
B5ME193954371914ChainID=PRO_0000422825;Note=Eukaryotic translation initiation factor 3 subunit C-like protein


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Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
all structure

check buttonExpression level of gene isoforms across TCGA pancancer
all structure

check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
all structure

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
LUADEIF3CL-2.136162026817330.000327584192623451
LUSCEIF3CL-1.658910705926990.00704157337736851
BRCAEIF3CL-1.451291153445640.0202464785451748
HNSCEIF3CL-1.693462095982130.028266192551655


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through copy number variation of Translation factor
Cancer typeGeneCoefficientPvalue
TGCTEIF3CL0.0911453710.007596085
PAADEIF3CL-0.3027446370.016788971
LUSCEIF3CL0.0769082160.039045134

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with EIF3CL (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
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* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
COADEIF3CLEIF3K-1.815560463906970.000109195709228516
LIHCEIF3CLEIF3H-1.904408803919850.000201991820198738
LUADEIF3CLEIF3D-2.47246314411060.000299564272708473
PRADEIF3CLEIF3A1.136803283919520.000363360004697762
KIRPEIF3CLEIF3F-2.666798348731280.00143672106787562
KIRCEIF3CLEIF3F-1.29927472561020.00267981494905134
BLCAEIF3CLEIF3F-2.420453545345880.00457763671875
COADEIF3CLEIF3L-1.922667940966820.00468936562538148
KIRPEIF3CLEIF3G-2.41783229621290.00471024587750435
THCAEIF3CLEIF3H-1.363898051608820.00492925389458784
BLCAEIF3CLEIF3A-4.451040583077470.00532913208007812
LIHCEIF3CLEIF3E-5.17223325998540.00593802028362182
KICHEIF3CLEIF3D-5.649428670230170.0202749371528625
UCECEIF3CLEIF3G-3.350783346965710.03125
UCECEIF3CLEIF3L-12.50796541755110.03125
BLCAEIF3CLEIF3G-3.077075596490910.0323410034179688
LUADEIF3CLEIF3B-5.804355875467621.0542655358657e-09
KIRCEIF3CLEIF3D-2.335018768320581.16831478033445e-08
LUSCEIF3CLEIF3H-2.961376895547721.45608838900009e-05
BRCAEIF3CLEIF3G1.879483850112711.9107949115022e-06
KIRCEIF3CLEIF3B-1.563132637845172.35252849767166e-12
LIHCEIF3CLEIF3D-2.518543046327992.35319665208461e-06
STADEIF3CLEIF3B-4.77246609720073.25962901115418e-08
LUADEIF3CLEIF3M-1.54295739683084.40678669801292e-06
HNSCEIF3CLEIF3B2.62025542636044.48234413852334e-06
KIRPEIF3CLEIF3B-2.75922970429744.6566128730774e-09
BRCAEIF3CLEIF3A-1.2182155731487.39403582934137e-06
KIRCEIF3CLEIF3E-4.498241012194627.8509870430991e-09
KIRCEIF3CLEIF3M-2.008881346589988.07326657761222e-05
BRCAEIF3CLEIF3E-1.484083480624639.51829316317813e-08
KIRCEIF3CLEIF3H-1.03322192578129.65225899474882e-06


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with EIF3CL
Itsn2, CUL3, CD81, IGSF8, ICAM1, EIF3A, DYNC1I2, RPL23A, RPL35, RPS11, RPS20, RPS23, RPS26, RPS27, RPS3A, RPS4X, RPS5, RPS6, SND1, EIF3E, NUDT21, RPS12, RPS18, RPS24, RPS2, RPS3, EIF3I, EIF3F, EIF3H, EIF3M, EIF3B, EIF3K, EIF3L, EIF3D, EIF3G, MCM2, OCRL, CLTB, APPL1, CLTA, UBE2M, ESR2, FAM35A, NR2C2, BIRC3, MIB1, RAB5A, HIST1H1B, CIT, ANLN, ECT2, KIF14, BCAR1, UFL1, DDRGK1, CKAP4, DHFRL1, IMPDH2, FZR1, EIF3C, BRD3,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
EIF3CLCESCchr162840335328403355TCC-In_Frame_Delp.ED295del5
EIF3CLLUADchr162873462728734627GTNonsense_Mutationp.G308*1
EIF3CLSTADchr162873480128734801GTMissense_Mutationp.E324D1
EIF3CLSTADchr162873462128734621CTMissense_Mutationp.R306W1
EIF3CLLIHCchr162840316428403164T-Frame_Shift_Delp.M318fs1
EIF3CLLUADchr162840335328403358TCCTCC-In_Frame_Delp.EED294del1
EIF3CLLUADchr162873478828734788CGMissense_Mutationp.A320G1

check buttonCopy number variation (CNV) of EIF3CL
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across EIF3CL
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
96062N/ABM145222ABCC4chr1395736910+EIF3CLchr1628391038+
96062N/ABI860079ACTG1chr1779476997-EIF3CLchr1628407988+
99276N/ABG957436EIF3CLchr1628412550-MED24chr1738178965-
61165N/AEC496672EIF3CLchr1628339678-SBK1chr1628296823-
99998N/ABC073965EIF3CLchr1628394571-SETD3chr1499929874-
96062STADTCGA-BR-7722-01ARAVER1chr1910439318-EIF3CLchr1628394802-
96071N/ABC022332UBE2E2chr323632070+EIF3CLchr1628408560-


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
PAADEIF3CL0.004695448831792160.13
TGCTEIF3CL0.01156398745683250.31
ACCEIF3CL0.01895147120814720.49

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
KIRPEIF3CL0.005673534680810750.19
LGGEIF3CL0.01088574267235330.34
BLCAEIF3CL0.009572797872492710.31

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source