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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: TYMS (NCBI Gene ID:7298)

Gene Summary

Gene Summary

Gene Information	Gene Name: TYMS
	Gene ID: 7298
	Gene Symbol	TYMS
	Gene ID	7298
	Gene Name	thymidylate synthetase
	Synonyms	HST422\|TMS\|TS
	Cytomap	18p11.32
	Type of Gene	protein-coding
	Description	thymidylate synthaseTSase
	Modification date	20200322
	UniProtAcc	P04818

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TYMS	GO:0006231	dTMP biosynthetic process	8845352\|11278511\|15093541
Hgene	TYMS	GO:0017148	negative regulation of translation	1924359
Hgene	TYMS	GO:0035999	tetrahydrofolate interconversion	15093541

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
TYMS	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'TYMS[title] AND translation [title] AND human.'

Gene	Title	PMID
TYMS	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000323274	669071	669173	In-frame
ENST00000323274	670691	670867	Frame-shift
ENST00000323274	671379	671451	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000323274	669071	669173	1679	594	695	313	151	185
ENST00000323274	671379	671451	1679	872	943	313	244	268

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P04818	244	268	2	313	Chain	ID=PRO_0000140901;Note=Thymidylate synthase
P04818	151	185	2	313	Chain	ID=PRO_0000140901;Note=Thymidylate synthase
P04818	151	185	175	176	Nucleotide binding	Note=dUMP%3B shared with dimeric partner;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P0A884
P04818	244	268	256	258	Nucleotide binding	Note=dUMP;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P0A884
P04818	151	185	69	151	Alternative sequence	ID=VSP_047745;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12706868;Dbxref=PMID:12706868
P04818	151	185	152	185	Alternative sequence	ID=VSP_047746;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:12706868;Dbxref=PMID:12706868
P04818	151	185	149	151	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3ED7
P04818	151	185	156	158	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3EHI
P04818	151	185	160	170	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3ED7
P04818	151	185	178	181	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3ED7
P04818	151	185	184	186	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3ED7
P04818	244	268	244	258	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3ED7
P04818	244	268	259	261	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3ED7
P04818	244	268	262	268	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3ED7

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	TYMS	-4.53846013082046	3.59910232594763e-11
KIRP	TYMS	-4.74916718066695	5.12227416038514e-08
THCA	TYMS	-1.40396152011229	6.91106419786075e-09
BRCA	TYMS	-3.84487671935658	8.59195631465592e-27
LIHC	TYMS	-2.69821117051716	9.87002535347663e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
DLBC	TYMS	hsa-miR-501-5p	90	0.306313598519889	0.0366874988936572

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LGG	TYMS	0.080539717	0.008655671
LIHC	TYMS	0.054285477	0.039130488

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with TYMS (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	Cell metabolism gene	TYMS	TK1	0.801987939	6.59E-19
ACC	Cell metabolism gene	TYMS	RRM2	0.900899223	1.23E-29
ACC	CGC	TYMS	BUB1B	0.861623657	2.20E-24
ACC	Epifactor	TYMS	AURKA	0.801048736	7.76E-19
ACC	Epifactor	TYMS	RAD54L	0.810967456	1.32E-19
ACC	Epifactor	TYMS	GSG2	0.812493218	9.99E-20
ACC	Epifactor	TYMS	UBE2T	0.81451977	6.85E-20
ACC	Epifactor	TYMS	CENPA	0.83629221	8.63E-22
ACC	Epifactor	TYMS	UHRF1	0.837868054	6.14E-22
ACC	Epifactor	TYMS	HJURP	0.845185116	1.20E-22
ACC	Epifactor	TYMS	CDK1	0.855653353	9.94E-24
ACC	Epifactor	TYMS	AURKB	0.861505708	2.26E-24
ACC	Epifactor	TYMS	BUB1	0.863119756	1.49E-24
ACC	Epifactor	TYMS	PBK	0.866274675	6.45E-25
ACC	Epifactor	TYMS	TOP2A	0.866656566	5.82E-25
ACC	Epifactor	TYMS	RAD51	0.888472594	9.15E-28
ACC	IUPHAR	TYMS	AURKA	0.801048736	7.76E-19
ACC	IUPHAR	TYMS	NEK2	0.812472333	1.00E-19
ACC	IUPHAR	TYMS	BIRC5	0.813970146	7.59E-20
ACC	IUPHAR	TYMS	KIF11	0.837756661	6.29E-22
ACC	IUPHAR	TYMS	PKMYT1	0.837866553	6.14E-22
ACC	IUPHAR	TYMS	MELK	0.850338131	3.60E-23
ACC	IUPHAR	TYMS	CDK1	0.855653353	9.94E-24
ACC	IUPHAR	TYMS	AURKB	0.861505708	2.26E-24
ACC	IUPHAR	TYMS	BUB1B	0.861623657	2.20E-24
ACC	IUPHAR	TYMS	BUB1	0.863119756	1.49E-24
ACC	IUPHAR	TYMS	PBK	0.866274675	6.45E-25
ACC	IUPHAR	TYMS	TOP2A	0.866656566	5.82E-25
ACC	IUPHAR	TYMS	PLK1	0.879754365	1.40E-26
ACC	IUPHAR	TYMS	RRM2	0.900899223	1.23E-29
ACC	Kinase	TYMS	AURKA	0.801048736	7.76E-19
ACC	Kinase	TYMS	NEK2	0.812472333	1.00E-19
ACC	Kinase	TYMS	GSG2	0.812493218	9.99E-20
ACC	Kinase	TYMS	PKMYT1	0.837866553	6.14E-22
ACC	Kinase	TYMS	MELK	0.850338131	3.60E-23
ACC	Kinase	TYMS	CDK1	0.855653353	9.94E-24
ACC	Kinase	TYMS	AURKB	0.861505708	2.26E-24
ACC	Kinase	TYMS	BUB1B	0.861623657	2.20E-24
ACC	Kinase	TYMS	BUB1	0.863119756	1.49E-24
ACC	Kinase	TYMS	PBK	0.866274675	6.45E-25
ACC	Kinase	TYMS	PLK1	0.879754365	1.40E-26
ACC	TF	TYMS	CENPA	0.83629221	8.63E-22
ACC	TF	TYMS	E2F2	0.86450835	1.03E-24
ACC	TF	TYMS	FOXM1	0.865243809	8.50E-25
ACC	TF	TYMS	MYBL2	0.870568776	2.00E-25
ACC	TSG	TYMS	E2F2	0.86450835	1.03E-24
ACC	TSG	TYMS	PLK1	0.879754365	1.40E-26
BRCA	Epifactor	TYMS	BUB1	0.805773478	6.25E-279
BRCA	Epifactor	TYMS	CENPA	0.808218801	6.40E-282
BRCA	Epifactor	TYMS	HJURP	0.814655378	5.33E-290
BRCA	Epifactor	TYMS	AURKB	0.822731197	1.35E-300
BRCA	Epifactor	TYMS	RAD51	0.822796657	1.11E-300
BRCA	Epifactor	TYMS	RAD54L	0.849602747	0
BRCA	IUPHAR	TYMS	BUB1	0.805773478	6.25E-279
BRCA	IUPHAR	TYMS	MELK	0.808771025	1.33E-282
BRCA	IUPHAR	TYMS	PLK1	0.816398278	3.05E-292
BRCA	IUPHAR	TYMS	AURKB	0.822731197	1.35E-300
BRCA	Kinase	TYMS	BUB1	0.805773478	6.25E-279
BRCA	Kinase	TYMS	MELK	0.808771025	1.33E-282
BRCA	Kinase	TYMS	PLK1	0.816398278	3.05E-292
BRCA	Kinase	TYMS	AURKB	0.822731197	1.35E-300
BRCA	TF	TYMS	E2F2	0.803994497	8.79E-277
BRCA	TF	TYMS	CENPA	0.808218801	6.40E-282
BRCA	TF	TYMS	FOXM1	0.827840463	1.40E-307
BRCA	TSG	TYMS	E2F2	0.803994497	8.79E-277
BRCA	TSG	TYMS	PLK1	0.816398278	3.05E-292
CHOL	Cell metabolism gene	TYMS	TK1	0.819410788	5.92E-12
CHOL	CGC	TYMS	EZH2	0.800686563	4.04E-11
CHOL	CGC	TYMS	BUB1B	0.804495162	2.78E-11
CHOL	Epifactor	TYMS	HJURP	0.8001554	4.25E-11
CHOL	Epifactor	TYMS	EZH2	0.800686563	4.04E-11
CHOL	Epifactor	TYMS	CHAF1B	0.804031051	2.91E-11
CHOL	Epifactor	TYMS	AURKB	0.805982493	2.39E-11
CHOL	Epifactor	TYMS	CENPA	0.81041549	1.53E-11
CHOL	Epifactor	TYMS	RAD54L	0.810503759	1.51E-11
CHOL	Epifactor	TYMS	ASF1B	0.812049732	1.29E-11
CHOL	Epifactor	TYMS	RAD51	0.82367059	3.71E-12
CHOL	Epifactor	TYMS	CDC6	0.824423345	3.41E-12
CHOL	IUPHAR	TYMS	EZH2	0.800686563	4.04E-11
CHOL	IUPHAR	TYMS	BUB1B	0.804495162	2.78E-11
CHOL	IUPHAR	TYMS	AURKB	0.805982493	2.39E-11
CHOL	Kinase	TYMS	BUB1B	0.804495162	2.78E-11
CHOL	Kinase	TYMS	AURKB	0.805982493	2.39E-11
CHOL	TF	TYMS	FOXM1	0.801860355	3.60E-11
CHOL	TF	TYMS	CENPA	0.81041549	1.53E-11
CHOL	TSG	TYMS	EZH2	0.800686563	4.04E-11
GBM	Cell metabolism gene	TYMS	TK1	0.815241735	3.50E-42
GBM	Epifactor	TYMS	AURKB	0.801592774	8.02E-40
GBM	Epifactor	TYMS	CENPA	0.810382007	2.55E-41
GBM	Epifactor	TYMS	AURKA	0.812642699	1.02E-41
GBM	Epifactor	TYMS	RAD51	0.821280169	2.74E-43
GBM	Epifactor	TYMS	ASF1B	0.855066942	2.31E-50
GBM	IUPHAR	TYMS	AURKB	0.801592774	8.02E-40
GBM	IUPHAR	TYMS	AURKA	0.812642699	1.02E-41
GBM	IUPHAR	TYMS	BIRC5	0.818360649	9.50E-43
GBM	IUPHAR	TYMS	MELK	0.82939176	7.63E-45
GBM	Kinase	TYMS	AURKB	0.801592774	8.02E-40
GBM	Kinase	TYMS	AURKA	0.812642699	1.02E-41
GBM	Kinase	TYMS	MELK	0.82939176	7.63E-45
GBM	TF	TYMS	CENPA	0.810382007	2.55E-41
LAML	Cell metabolism gene	TYMS	RRM2	0.804342505	1.65E-40
LAML	CGC	TYMS	FEN1	0.823600636	5.66E-44
LAML	Epifactor	TYMS	CHAF1B	0.808018463	3.85E-41
LAML	Epifactor	TYMS	RAD54L	0.838810958	5.07E-47
LAML	Epifactor	TYMS	CDC6	0.856563244	5.25E-51
LAML	Epifactor	TYMS	RAD51	0.863313016	1.15E-52
LAML	Epifactor	TYMS	PCNA	0.864189994	6.92E-53
LAML	IUPHAR	TYMS	RRM2	0.804342505	1.65E-40
LAML	TF	TYMS	FOXM1	0.840278847	2.48E-47
LGG	Cell metabolism gene	TYMS	TK1	0.845521422	5.37E-146
LGG	Epifactor	TYMS	ASF1B	0.805693579	3.54E-122
LGG	TF	TYMS	E2F7	0.820017702	4.64E-130
LGG	TF	TYMS	E2F1	0.823399777	5.05E-132
LGG	TSG	TYMS	E2F1	0.823399777	5.05E-132
LIHC	Epifactor	TYMS	RAD51	0.801706194	3.89E-96
LIHC	Epifactor	TYMS	RAD54L	0.804310527	3.25E-97
LIHC	Epifactor	TYMS	HELLS	0.808030957	8.78E-99
LUAD	Cell metabolism gene	TYMS	HMMR	0.822405464	9.96E-143
LUAD	Cell metabolism gene	TYMS	RRM2	0.856950823	2.29E-167
LUAD	CGC	TYMS	BRIP1	0.811978222	2.51E-136
LUAD	CGC	TYMS	FEN1	0.814889052	4.51E-138
LUAD	CGC	TYMS	STIL	0.820745542	1.11E-141
LUAD	CGC	TYMS	BUB1B	0.853348233	1.66E-164
LUAD	Epifactor	TYMS	AURKA	0.800181589	1.50E-129
LUAD	Epifactor	TYMS	UBE2T	0.806191514	6.06E-133
LUAD	Epifactor	TYMS	CHEK1	0.808992783	1.44E-134
LUAD	Epifactor	TYMS	UHRF1	0.810650652	1.54E-135
LUAD	Epifactor	TYMS	HELLS	0.819458474	7.07E-141
LUAD	Epifactor	TYMS	AURKB	0.831345154	1.47E-148
LUAD	Epifactor	TYMS	CDK1	0.841320752	1.73E-155
LUAD	Epifactor	TYMS	ASF1B	0.847199195	8.46E-160
LUAD	Epifactor	TYMS	TOP2A	0.849660353	1.17E-161
LUAD	Epifactor	TYMS	CENPA	0.849946922	7.07E-162
LUAD	Epifactor	TYMS	TTK	0.850517959	2.59E-162
LUAD	Epifactor	TYMS	RAD51	0.852714104	5.18E-164
LUAD	Epifactor	TYMS	HJURP	0.852792991	4.50E-164
LUAD	Epifactor	TYMS	RAD54L	0.854201531	3.54E-165
LUAD	Epifactor	TYMS	BUB1	0.855492294	3.36E-166
LUAD	Epifactor	TYMS	CDC6	0.858842057	6.70E-169
LUAD	IUPHAR	TYMS	AURKA	0.800181589	1.50E-129
LUAD	IUPHAR	TYMS	CHEK1	0.808992783	1.44E-134
LUAD	IUPHAR	TYMS	PLK4	0.829137778	4.34E-147
LUAD	IUPHAR	TYMS	NEK2	0.830736084	3.75E-148
LUAD	IUPHAR	TYMS	AURKB	0.831345154	1.47E-148
LUAD	IUPHAR	TYMS	KIF11	0.834524834	1.02E-150
LUAD	IUPHAR	TYMS	BIRC5	0.83764745	6.98E-153
LUAD	IUPHAR	TYMS	PLK1	0.839477019	3.58E-154
LUAD	IUPHAR	TYMS	CDK1	0.841320752	1.73E-155
LUAD	IUPHAR	TYMS	TOP2A	0.849660353	1.17E-161
LUAD	IUPHAR	TYMS	TTK	0.850517959	2.59E-162
LUAD	IUPHAR	TYMS	BUB1B	0.853348233	1.66E-164
LUAD	IUPHAR	TYMS	BUB1	0.855492294	3.36E-166
LUAD	IUPHAR	TYMS	RRM2	0.856950823	2.29E-167
LUAD	IUPHAR	TYMS	MELK	0.863549884	8.15E-173
LUAD	Kinase	TYMS	AURKA	0.800181589	1.50E-129
LUAD	Kinase	TYMS	CHEK1	0.808992783	1.44E-134
LUAD	Kinase	TYMS	PLK4	0.829137778	4.34E-147
LUAD	Kinase	TYMS	NEK2	0.830736084	3.75E-148
LUAD	Kinase	TYMS	AURKB	0.831345154	1.47E-148
LUAD	Kinase	TYMS	PLK1	0.839477019	3.58E-154
LUAD	Kinase	TYMS	CDK1	0.841320752	1.73E-155
LUAD	Kinase	TYMS	TTK	0.850517959	2.59E-162
LUAD	Kinase	TYMS	BUB1B	0.853348233	1.66E-164
LUAD	Kinase	TYMS	BUB1	0.855492294	3.36E-166
LUAD	Kinase	TYMS	MELK	0.863549884	8.15E-173
LUAD	TF	TYMS	FOXM1	0.819297045	8.91E-141
LUAD	TF	TYMS	MYBL2	0.834110274	1.96E-150
LUAD	TF	TYMS	CENPA	0.849946922	7.07E-162
LUAD	TSG	TYMS	CHEK1	0.808992783	1.44E-134
LUAD	TSG	TYMS	PLK1	0.839477019	3.58E-154
LUSC	CGC	TYMS	BUB1B	0.801389823	4.43E-125
LUSC	Epifactor	TYMS	ASF1B	0.803828519	2.13E-126
LUSC	Epifactor	TYMS	CENPA	0.805318416	3.27E-127
LUSC	Epifactor	TYMS	RAD54L	0.805944231	1.48E-127
LUSC	Epifactor	TYMS	AURKB	0.806821161	4.85E-128
LUSC	Epifactor	TYMS	TOP2A	0.810302937	5.47E-130
LUSC	Epifactor	TYMS	BUB1	0.813399853	9.37E-132
LUSC	Epifactor	TYMS	CDC6	0.81703107	7.21E-134
LUSC	IUPHAR	TYMS	BIRC5	0.800066765	2.26E-124
LUSC	IUPHAR	TYMS	BUB1B	0.801389823	4.43E-125
LUSC	IUPHAR	TYMS	AURKB	0.806821161	4.85E-128
LUSC	IUPHAR	TYMS	TOP2A	0.810302937	5.47E-130
LUSC	IUPHAR	TYMS	BUB1	0.813399853	9.37E-132
LUSC	Kinase	TYMS	BUB1B	0.801389823	4.43E-125
LUSC	Kinase	TYMS	AURKB	0.806821161	4.85E-128
LUSC	Kinase	TYMS	BUB1	0.813399853	9.37E-132
LUSC	TF	TYMS	MYBL2	0.802665217	9.11E-126
LUSC	TF	TYMS	CENPA	0.805318416	3.27E-127
MESO	Cell metabolism gene	TYMS	TK1	0.802402293	9.40E-21
MESO	Cell metabolism gene	TYMS	RRM2	0.835777341	7.59E-24
MESO	Epifactor	TYMS	BUB1	0.808190914	3.02E-21
MESO	Epifactor	TYMS	ASF1B	0.808862262	2.65E-21
MESO	Epifactor	TYMS	CENPA	0.825126695	8.67E-23
MESO	Epifactor	TYMS	AURKB	0.843143891	1.27E-24
MESO	Epifactor	TYMS	UHRF1	0.851417901	1.52E-25
MESO	Epifactor	TYMS	RAD54L	0.851442262	1.51E-25
MESO	IUPHAR	TYMS	BUB1	0.808190914	3.02E-21
MESO	IUPHAR	TYMS	PLK1	0.813490356	1.03E-21
MESO	IUPHAR	TYMS	PKMYT1	0.824049899	1.10E-22
MESO	IUPHAR	TYMS	RRM2	0.835777341	7.59E-24
MESO	IUPHAR	TYMS	BIRC5	0.836042637	7.12E-24
MESO	IUPHAR	TYMS	AURKB	0.843143891	1.27E-24
MESO	Kinase	TYMS	BUB1	0.808190914	3.02E-21
MESO	Kinase	TYMS	PLK1	0.813490356	1.03E-21
MESO	Kinase	TYMS	PKMYT1	0.824049899	1.10E-22
MESO	Kinase	TYMS	AURKB	0.843143891	1.27E-24
MESO	TF	TYMS	CENPA	0.825126695	8.67E-23
MESO	TF	TYMS	MYBL2	0.836850837	5.88E-24
MESO	TSG	TYMS	PLK1	0.813490356	1.03E-21
PCPG	Epifactor	TYMS	RAD51	0.836666995	2.99E-50
STAD	Epifactor	TYMS	RAD51	0.810298329	4.91E-106
STAD	Epifactor	TYMS	RAD54L	0.813952617	9.84E-108
TGCT	Cell metabolism gene	TYMS	VCAN	0.805859683	7.07E-37
TGCT	Cell metabolism gene	TYMS	GPC3	0.852750458	2.74E-45
TGCT	CGC	TYMS	DEK	0.813752921	4.01E-38
TGCT	CGC	TYMS	ID3	0.822695118	1.31E-39
TGCT	CGC	TYMS	GPC3	0.852750458	2.74E-45
TGCT	Epifactor	TYMS	DEK	0.813752921	4.01E-38
TGCT	IUPHAR	TYMS	TNFRSF10B	0.807338243	4.17E-37
TGCT	IUPHAR	TYMS	GJA1	0.817879939	8.46E-39
TGCT	IUPHAR	TYMS	GPC3	0.852750458	2.74E-45
TGCT	TSG	TYMS	TNFRSF10B	0.807338243	4.17E-37
TGCT	TSG	TYMS	GJA1	0.817879939	8.46E-39
TGCT	TSG	TYMS	GPC3	0.852750458	2.74E-45
THCA	Cell metabolism gene	TYMS	TK1	0.814629309	5.74E-137
THCA	Epifactor	TYMS	HELLS	0.802494061	6.07E-130
THCA	Epifactor	TYMS	CDC6	0.82929156	3.53E-146
THCA	Epifactor	TYMS	ASF1B	0.85874837	1.16E-167
THCA	Epifactor	TYMS	UHRF1	0.868740541	4.40E-176
THCA	TF	TYMS	E2F1	0.818061265	4.76E-139
THCA	TSG	TYMS	E2F1	0.818061265	4.76E-139
THYM	Cell metabolism gene	TYMS	PPP2R5D	0.803275435	8.91E-29
THYM	Cell metabolism gene	TYMS	SMPD3	0.805864746	4.37E-29
THYM	Cell metabolism gene	TYMS	LBR	0.807535888	2.75E-29
THYM	Cell metabolism gene	TYMS	DUT	0.809877324	1.42E-29
THYM	Cell metabolism gene	TYMS	GNA15	0.810361283	1.24E-29
THYM	Cell metabolism gene	TYMS	PAFAH2	0.812407775	6.89E-30
THYM	Cell metabolism gene	TYMS	ELOVL4	0.813535984	4.97E-30
THYM	Cell metabolism gene	TYMS	PRIM2	0.813886397	4.49E-30
THYM	Cell metabolism gene	TYMS	SEH1L	0.816599317	2.03E-30
THYM	Cell metabolism gene	TYMS	LCT	0.822708703	3.23E-31
THYM	Cell metabolism gene	TYMS	POLE2	0.82378541	2.32E-31
THYM	Cell metabolism gene	TYMS	RRM1	0.830998121	2.37E-32
THYM	Cell metabolism gene	TYMS	ADA	0.851488925	1.94E-35
THYM	Cell metabolism gene	TYMS	HMMR	0.861824202	3.52E-37
THYM	Cell metabolism gene	TYMS	RPIA	0.870555764	9.20E-39
THYM	Cell metabolism gene	TYMS	ACAT2	0.873814893	2.20E-39
THYM	Cell metabolism gene	TYMS	RRM2	0.895234578	6.05E-44
THYM	Cell metabolism gene	TYMS	TUBA1B	0.903742429	4.87E-46
THYM	CGC	TYMS	CDK6	0.80034236	1.97E-28
THYM	CGC	TYMS	BCL7A	0.800351684	1.97E-28
THYM	CGC	TYMS	FANCD2	0.803908405	7.49E-29
THYM	CGC	TYMS	FNBP1	0.805073583	5.44E-29
THYM	CGC	TYMS	MLLT11	0.806604771	3.56E-29
THYM	CGC	TYMS	LCK	0.814813024	3.43E-30
THYM	CGC	TYMS	RAP1GDS1	0.823516052	2.52E-31
THYM	CGC	TYMS	MYB	0.826548742	9.80E-32
THYM	CGC	TYMS	EWSR1	0.83502126	6.34E-33
THYM	CGC	TYMS	EZH2	0.83925088	1.53E-33
THYM	CGC	TYMS	CDKN2C	0.84770709	7.77E-35
THYM	CGC	TYMS	SFPQ	0.847786337	7.55E-35
THYM	CGC	TYMS	SET	0.849893197	3.50E-35
THYM	CGC	TYMS	BLM	0.853185668	1.02E-35
THYM	CGC	TYMS	BUB1B	0.858363852	1.40E-36
THYM	CGC	TYMS	FEN1	0.871114448	7.22E-39
THYM	CGC	TYMS	TCF3	0.88285807	3.36E-41
THYM	Epifactor	TYMS	H2AFY	0.802432869	1.12E-28
THYM	Epifactor	TYMS	H2AFV	0.80577724	4.48E-29
THYM	Epifactor	TYMS	LBR	0.807535888	2.75E-29
THYM	Epifactor	TYMS	H2AFX	0.809173492	1.73E-29
THYM	Epifactor	TYMS	UBE2T	0.811172018	9.82E-30
THYM	Epifactor	TYMS	AURKA	0.817490735	1.56E-30
THYM	Epifactor	TYMS	CBX3	0.817677794	1.47E-30
THYM	Epifactor	TYMS	H1FX	0.818466261	1.17E-30
THYM	Epifactor	TYMS	GFI1	0.828464087	5.35E-32
THYM	Epifactor	TYMS	MTA3	0.828853781	4.72E-32
THYM	Epifactor	TYMS	HMGN2	0.830994598	2.37E-32
THYM	Epifactor	TYMS	CHEK1	0.833740249	9.69E-33
THYM	Epifactor	TYMS	EZH2	0.83925088	1.53E-33
THYM	Epifactor	TYMS	GSG2	0.844698808	2.29E-34
THYM	Epifactor	TYMS	HMGB1	0.845526133	1.70E-34
THYM	Epifactor	TYMS	PBK	0.846823047	1.07E-34
THYM	Epifactor	TYMS	CDK1	0.847234235	9.22E-35
THYM	Epifactor	TYMS	SFPQ	0.847786337	7.55E-35
THYM	Epifactor	TYMS	SET	0.849893197	3.50E-35
THYM	Epifactor	TYMS	CBX2	0.854185133	7.01E-36
THYM	Epifactor	TYMS	CDC6	0.855377931	4.45E-36
THYM	Epifactor	TYMS	CHAF1A	0.856885747	2.49E-36
THYM	Epifactor	TYMS	AURKB	0.858414211	1.37E-36
THYM	Epifactor	TYMS	TOP2A	0.858668191	1.24E-36
THYM	Epifactor	TYMS	H2AFZ	0.860890196	5.13E-37
THYM	Epifactor	TYMS	CENPA	0.867154736	3.92E-38
THYM	Epifactor	TYMS	UHRF1	0.867961764	2.79E-38
THYM	Epifactor	TYMS	VRK1	0.874557739	1.58E-39
THYM	Epifactor	TYMS	BUB1	0.875697508	9.47E-40
THYM	Epifactor	TYMS	TTK	0.879759988	1.46E-40
THYM	Epifactor	TYMS	HJURP	0.882338536	4.31E-41
THYM	Epifactor	TYMS	ASF1B	0.882926625	3.25E-41
THYM	Epifactor	TYMS	RAD54L	0.884301493	1.67E-41
THYM	Epifactor	TYMS	PCNA	0.886171653	6.65E-42
THYM	Epifactor	TYMS	RAD51	0.913395819	1.15E-48
THYM	IUPHAR	TYMS	CDK6	0.80034236	1.97E-28
THYM	IUPHAR	TYMS	SMPD3	0.805864746	4.37E-29
THYM	IUPHAR	TYMS	CHRNA3	0.806320256	3.85E-29
THYM	IUPHAR	TYMS	PVRIG	0.809949551	1.39E-29
THYM	IUPHAR	TYMS	PAFAH2	0.812407775	6.89E-30
THYM	IUPHAR	TYMS	MME	0.813952461	4.41E-30
THYM	IUPHAR	TYMS	LCK	0.814813024	3.43E-30
THYM	IUPHAR	TYMS	AURKA	0.817490735	1.56E-30
THYM	IUPHAR	TYMS	KCNJ4	0.825954977	1.18E-31
THYM	IUPHAR	TYMS	RRM1	0.830998121	2.37E-32
THYM	IUPHAR	TYMS	CHEK1	0.833740249	9.69E-33
THYM	IUPHAR	TYMS	EZH2	0.83925088	1.53E-33
THYM	IUPHAR	TYMS	NEK2	0.842314065	5.30E-34
THYM	IUPHAR	TYMS	SLC29A1	0.8428876	4.33E-34
THYM	IUPHAR	TYMS	KIF11	0.846197544	1.34E-34
THYM	IUPHAR	TYMS	PBK	0.846823047	1.07E-34
THYM	IUPHAR	TYMS	CDK1	0.847234235	9.22E-35
THYM	IUPHAR	TYMS	PKMYT1	0.847922145	7.19E-35
THYM	IUPHAR	TYMS	ADA	0.851488925	1.94E-35
THYM	IUPHAR	TYMS	MELK	0.855244653	4.68E-36
THYM	IUPHAR	TYMS	BUB1B	0.858363852	1.40E-36
THYM	IUPHAR	TYMS	AURKB	0.858414211	1.37E-36
THYM	IUPHAR	TYMS	TOP2A	0.858668191	1.24E-36
THYM	IUPHAR	TYMS	ACAT2	0.873814893	2.20E-39
THYM	IUPHAR	TYMS	VRK1	0.874557739	1.58E-39
THYM	IUPHAR	TYMS	PLK4	0.875489477	1.04E-39
THYM	IUPHAR	TYMS	BUB1	0.875697508	9.47E-40
THYM	IUPHAR	TYMS	TTK	0.879759988	1.46E-40
THYM	IUPHAR	TYMS	TUBB	0.89026929	8.36E-43
THYM	IUPHAR	TYMS	PLK1	0.892218893	3.03E-43
THYM	IUPHAR	TYMS	RRM2	0.895234578	6.05E-44
THYM	Kinase	TYMS	CDK6	0.80034236	1.97E-28
THYM	Kinase	TYMS	LCK	0.814813024	3.43E-30
THYM	Kinase	TYMS	AURKA	0.817490735	1.56E-30
THYM	Kinase	TYMS	CHEK1	0.833740249	9.69E-33
THYM	Kinase	TYMS	NEK2	0.842314065	5.30E-34
THYM	Kinase	TYMS	GSG2	0.844698808	2.29E-34
THYM	Kinase	TYMS	PBK	0.846823047	1.07E-34
THYM	Kinase	TYMS	CDK1	0.847234235	9.22E-35
THYM	Kinase	TYMS	PKMYT1	0.847922145	7.19E-35
THYM	Kinase	TYMS	MELK	0.855244653	4.68E-36
THYM	Kinase	TYMS	BUB1B	0.858363852	1.40E-36
THYM	Kinase	TYMS	AURKB	0.858414211	1.37E-36
THYM	Kinase	TYMS	VRK1	0.874557739	1.58E-39
THYM	Kinase	TYMS	PLK4	0.875489477	1.04E-39
THYM	Kinase	TYMS	BUB1	0.875697508	9.47E-40
THYM	Kinase	TYMS	TTK	0.879759988	1.46E-40
THYM	Kinase	TYMS	PLK1	0.892218893	3.03E-43
THYM	TF	TYMS	TFDP2	0.810305879	1.26E-29
THYM	TF	TYMS	TCF7	0.811042876	1.02E-29
THYM	TF	TYMS	MYBL2	0.820844394	5.70E-31
THYM	TF	TYMS	MYB	0.826548742	9.80E-32
THYM	TF	TYMS	GFI1	0.828464087	5.35E-32
THYM	TF	TYMS	E2F8	0.853313755	9.76E-36
THYM	TF	TYMS	FOXM1	0.853664995	8.54E-36
THYM	TF	TYMS	CBX2	0.854185133	7.01E-36
THYM	TF	TYMS	CENPA	0.867154736	3.92E-38
THYM	TF	TYMS	E2F2	0.873855105	2.16E-39
THYM	TF	TYMS	TCF3	0.88285807	3.36E-41
THYM	TSG	TYMS	CDK6	0.80034236	1.97E-28
THYM	TSG	TYMS	H2AFX	0.809173492	1.73E-29
THYM	TSG	TYMS	MME	0.813952461	4.41E-30
THYM	TSG	TYMS	CHEK1	0.833740249	9.69E-33
THYM	TSG	TYMS	EZH2	0.83925088	1.53E-33
THYM	TSG	TYMS	CDKN2C	0.84770709	7.77E-35
THYM	TSG	TYMS	BLM	0.853185668	1.02E-35
THYM	TSG	TYMS	E2F2	0.873855105	2.16E-39
THYM	TSG	TYMS	PTPN2	0.87553249	1.02E-39
THYM	TSG	TYMS	TCF3	0.88285807	3.36E-41
THYM	TSG	TYMS	PLK1	0.892218893	3.03E-43
UCEC	Cell metabolism gene	TYMS	RRM2	0.832911512	4.97E-53
UCEC	CGC	TYMS	BLM	0.802480683	1.65E-46
UCEC	CGC	TYMS	FEN1	0.811093246	3.12E-48
UCEC	CGC	TYMS	BUB1B	0.833786322	3.09E-53
UCEC	Epifactor	TYMS	PCNA	0.804185234	7.66E-47
UCEC	Epifactor	TYMS	TTK	0.809886819	5.50E-48
UCEC	Epifactor	TYMS	UHRF1	0.816913769	1.89E-49
UCEC	Epifactor	TYMS	CDK1	0.819871436	4.38E-50
UCEC	Epifactor	TYMS	GSG2	0.823504924	7.01E-51
UCEC	Epifactor	TYMS	UBE2T	0.828491536	5.28E-52
UCEC	Epifactor	TYMS	AURKA	0.828738842	4.63E-52
UCEC	Epifactor	TYMS	HJURP	0.830832902	1.52E-52
UCEC	Epifactor	TYMS	TOP2A	0.833862327	2.96E-53
UCEC	Epifactor	TYMS	AURKB	0.835424605	1.26E-53
UCEC	Epifactor	TYMS	CENPA	0.837042526	5.12E-54
UCEC	Epifactor	TYMS	CHAF1A	0.840928051	5.70E-55
UCEC	Epifactor	TYMS	PBK	0.841821713	3.41E-55
UCEC	Epifactor	TYMS	RAD51	0.845388224	4.26E-56
UCEC	Epifactor	TYMS	BUB1	0.846212033	2.61E-56
UCEC	Epifactor	TYMS	RAD54L	0.846984297	1.65E-56
UCEC	Epifactor	TYMS	CDC6	0.852420547	6.01E-58
UCEC	Epifactor	TYMS	ASF1B	0.853494829	3.07E-58
UCEC	IUPHAR	TYMS	TTK	0.809886819	5.50E-48
UCEC	IUPHAR	TYMS	NEK2	0.814411552	6.38E-49
UCEC	IUPHAR	TYMS	CDK1	0.819871436	4.38E-50
UCEC	IUPHAR	TYMS	AURKA	0.828738842	4.63E-52
UCEC	IUPHAR	TYMS	PKMYT1	0.831250505	1.22E-52
UCEC	IUPHAR	TYMS	RRM2	0.832911512	4.97E-53
UCEC	IUPHAR	TYMS	BUB1B	0.833786322	3.09E-53
UCEC	IUPHAR	TYMS	TOP2A	0.833862327	2.96E-53
UCEC	IUPHAR	TYMS	AURKB	0.835424605	1.26E-53
UCEC	IUPHAR	TYMS	PBK	0.841821713	3.41E-55
UCEC	IUPHAR	TYMS	BUB1	0.846212033	2.61E-56
UCEC	IUPHAR	TYMS	KIF11	0.84691995	1.71E-56
UCEC	IUPHAR	TYMS	PLK1	0.862221293	1.08E-60
UCEC	IUPHAR	TYMS	MELK	0.867790764	2.37E-62
UCEC	Kinase	TYMS	TTK	0.809886819	5.50E-48
UCEC	Kinase	TYMS	NEK2	0.814411552	6.38E-49
UCEC	Kinase	TYMS	CDK1	0.819871436	4.38E-50
UCEC	Kinase	TYMS	GSG2	0.823504924	7.01E-51
UCEC	Kinase	TYMS	AURKA	0.828738842	4.63E-52
UCEC	Kinase	TYMS	PKMYT1	0.831250505	1.22E-52
UCEC	Kinase	TYMS	BUB1B	0.833786322	3.09E-53
UCEC	Kinase	TYMS	AURKB	0.835424605	1.26E-53
UCEC	Kinase	TYMS	PBK	0.841821713	3.41E-55
UCEC	Kinase	TYMS	BUB1	0.846212033	2.61E-56
UCEC	Kinase	TYMS	PLK1	0.862221293	1.08E-60
UCEC	Kinase	TYMS	MELK	0.867790764	2.37E-62
UCEC	TF	TYMS	MYBL2	0.826510751	1.49E-51
UCEC	TF	TYMS	E2F2	0.829405378	3.26E-52
UCEC	TF	TYMS	CENPA	0.837042526	5.12E-54
UCEC	TF	TYMS	FOXM1	0.867972712	2.09E-62
UCEC	TSG	TYMS	BLM	0.802480683	1.65E-46
UCEC	TSG	TYMS	E2F2	0.829405378	3.26E-52
UCEC	TSG	TYMS	PLK1	0.862221293	1.08E-60
UCS	Cell metabolism gene	TYMS	PPP2R5D	0.803275435	8.91E-29
UCS	Cell metabolism gene	TYMS	SMPD3	0.805864746	4.37E-29
UCS	Cell metabolism gene	TYMS	LBR	0.807535888	2.75E-29
UCS	Cell metabolism gene	TYMS	DUT	0.809877324	1.42E-29
UCS	Cell metabolism gene	TYMS	GNA15	0.810361283	1.24E-29
UCS	Cell metabolism gene	TYMS	PAFAH2	0.812407775	6.89E-30
UCS	Cell metabolism gene	TYMS	ELOVL4	0.813535984	4.97E-30
UCS	Cell metabolism gene	TYMS	PRIM2	0.813886397	4.49E-30
UCS	Cell metabolism gene	TYMS	SEH1L	0.816599317	2.03E-30
UCS	Cell metabolism gene	TYMS	LCT	0.822708703	3.23E-31
UCS	Cell metabolism gene	TYMS	POLE2	0.82378541	2.32E-31
UCS	Cell metabolism gene	TYMS	RRM1	0.830998121	2.37E-32
UCS	Cell metabolism gene	TYMS	ADA	0.851488925	1.94E-35
UCS	Cell metabolism gene	TYMS	HMMR	0.861824202	3.52E-37
UCS	Cell metabolism gene	TYMS	RPIA	0.870555764	9.20E-39
UCS	Cell metabolism gene	TYMS	ACAT2	0.873814893	2.20E-39
UCS	Cell metabolism gene	TYMS	RRM2	0.895234578	6.05E-44
UCS	Cell metabolism gene	TYMS	TUBA1B	0.903742429	4.87E-46
UCS	CGC	TYMS	CDK6	0.80034236	1.97E-28
UCS	CGC	TYMS	BCL7A	0.800351684	1.97E-28
UCS	CGC	TYMS	FANCD2	0.803908405	7.49E-29
UCS	CGC	TYMS	FNBP1	0.805073583	5.44E-29
UCS	CGC	TYMS	MLLT11	0.806604771	3.56E-29
UCS	CGC	TYMS	LCK	0.814813024	3.43E-30
UCS	CGC	TYMS	RAP1GDS1	0.823516052	2.52E-31
UCS	CGC	TYMS	MYB	0.826548742	9.80E-32
UCS	CGC	TYMS	EWSR1	0.83502126	6.34E-33
UCS	CGC	TYMS	EZH2	0.83925088	1.53E-33
UCS	CGC	TYMS	CDKN2C	0.84770709	7.77E-35
UCS	CGC	TYMS	SFPQ	0.847786337	7.55E-35
UCS	CGC	TYMS	SET	0.849893197	3.50E-35
UCS	CGC	TYMS	BLM	0.853185668	1.02E-35
UCS	CGC	TYMS	BUB1B	0.858363852	1.40E-36
UCS	CGC	TYMS	FEN1	0.871114448	7.22E-39
UCS	CGC	TYMS	TCF3	0.88285807	3.36E-41
UCS	Epifactor	TYMS	H2AFY	0.802432869	1.12E-28
UCS	Epifactor	TYMS	H2AFV	0.80577724	4.48E-29
UCS	Epifactor	TYMS	LBR	0.807535888	2.75E-29
UCS	Epifactor	TYMS	H2AFX	0.809173492	1.73E-29
UCS	Epifactor	TYMS	UBE2T	0.811172018	9.82E-30
UCS	Epifactor	TYMS	AURKA	0.817490735	1.56E-30
UCS	Epifactor	TYMS	CBX3	0.817677794	1.47E-30
UCS	Epifactor	TYMS	H1FX	0.818466261	1.17E-30
UCS	Epifactor	TYMS	GFI1	0.828464087	5.35E-32
UCS	Epifactor	TYMS	MTA3	0.828853781	4.72E-32
UCS	Epifactor	TYMS	HMGN2	0.830994598	2.37E-32
UCS	Epifactor	TYMS	CHEK1	0.833740249	9.69E-33
UCS	Epifactor	TYMS	EZH2	0.83925088	1.53E-33
UCS	Epifactor	TYMS	GSG2	0.844698808	2.29E-34
UCS	Epifactor	TYMS	HMGB1	0.845526133	1.70E-34
UCS	Epifactor	TYMS	PBK	0.846823047	1.07E-34
UCS	Epifactor	TYMS	CDK1	0.847234235	9.22E-35
UCS	Epifactor	TYMS	SFPQ	0.847786337	7.55E-35
UCS	Epifactor	TYMS	SET	0.849893197	3.50E-35
UCS	Epifactor	TYMS	CBX2	0.854185133	7.01E-36
UCS	Epifactor	TYMS	CDC6	0.855377931	4.45E-36
UCS	Epifactor	TYMS	CHAF1A	0.856885747	2.49E-36
UCS	Epifactor	TYMS	AURKB	0.858414211	1.37E-36
UCS	Epifactor	TYMS	TOP2A	0.858668191	1.24E-36
UCS	Epifactor	TYMS	H2AFZ	0.860890196	5.13E-37
UCS	Epifactor	TYMS	CENPA	0.867154736	3.92E-38
UCS	Epifactor	TYMS	UHRF1	0.867961764	2.79E-38
UCS	Epifactor	TYMS	VRK1	0.874557739	1.58E-39
UCS	Epifactor	TYMS	BUB1	0.875697508	9.47E-40
UCS	Epifactor	TYMS	TTK	0.879759988	1.46E-40
UCS	Epifactor	TYMS	HJURP	0.882338536	4.31E-41
UCS	Epifactor	TYMS	ASF1B	0.882926625	3.25E-41
UCS	Epifactor	TYMS	RAD54L	0.884301493	1.67E-41
UCS	Epifactor	TYMS	PCNA	0.886171653	6.65E-42
UCS	Epifactor	TYMS	RAD51	0.913395819	1.15E-48
UCS	IUPHAR	TYMS	CDK6	0.80034236	1.97E-28
UCS	IUPHAR	TYMS	SMPD3	0.805864746	4.37E-29
UCS	IUPHAR	TYMS	CHRNA3	0.806320256	3.85E-29
UCS	IUPHAR	TYMS	PVRIG	0.809949551	1.39E-29
UCS	IUPHAR	TYMS	PAFAH2	0.812407775	6.89E-30
UCS	IUPHAR	TYMS	MME	0.813952461	4.41E-30
UCS	IUPHAR	TYMS	LCK	0.814813024	3.43E-30
UCS	IUPHAR	TYMS	AURKA	0.817490735	1.56E-30
UCS	IUPHAR	TYMS	KCNJ4	0.825954977	1.18E-31
UCS	IUPHAR	TYMS	RRM1	0.830998121	2.37E-32
UCS	IUPHAR	TYMS	CHEK1	0.833740249	9.69E-33
UCS	IUPHAR	TYMS	EZH2	0.83925088	1.53E-33
UCS	IUPHAR	TYMS	NEK2	0.842314065	5.30E-34
UCS	IUPHAR	TYMS	SLC29A1	0.8428876	4.33E-34
UCS	IUPHAR	TYMS	KIF11	0.846197544	1.34E-34
UCS	IUPHAR	TYMS	PBK	0.846823047	1.07E-34
UCS	IUPHAR	TYMS	CDK1	0.847234235	9.22E-35
UCS	IUPHAR	TYMS	PKMYT1	0.847922145	7.19E-35
UCS	IUPHAR	TYMS	ADA	0.851488925	1.94E-35
UCS	IUPHAR	TYMS	MELK	0.855244653	4.68E-36
UCS	IUPHAR	TYMS	BUB1B	0.858363852	1.40E-36
UCS	IUPHAR	TYMS	AURKB	0.858414211	1.37E-36
UCS	IUPHAR	TYMS	TOP2A	0.858668191	1.24E-36
UCS	IUPHAR	TYMS	ACAT2	0.873814893	2.20E-39
UCS	IUPHAR	TYMS	VRK1	0.874557739	1.58E-39
UCS	IUPHAR	TYMS	PLK4	0.875489477	1.04E-39
UCS	IUPHAR	TYMS	BUB1	0.875697508	9.47E-40
UCS	IUPHAR	TYMS	TTK	0.879759988	1.46E-40
UCS	IUPHAR	TYMS	TUBB	0.89026929	8.36E-43
UCS	IUPHAR	TYMS	PLK1	0.892218893	3.03E-43
UCS	IUPHAR	TYMS	RRM2	0.895234578	6.05E-44
UCS	Kinase	TYMS	CDK6	0.80034236	1.97E-28
UCS	Kinase	TYMS	LCK	0.814813024	3.43E-30
UCS	Kinase	TYMS	AURKA	0.817490735	1.56E-30
UCS	Kinase	TYMS	CHEK1	0.833740249	9.69E-33
UCS	Kinase	TYMS	NEK2	0.842314065	5.30E-34
UCS	Kinase	TYMS	GSG2	0.844698808	2.29E-34
UCS	Kinase	TYMS	PBK	0.846823047	1.07E-34
UCS	Kinase	TYMS	CDK1	0.847234235	9.22E-35
UCS	Kinase	TYMS	PKMYT1	0.847922145	7.19E-35
UCS	Kinase	TYMS	MELK	0.855244653	4.68E-36
UCS	Kinase	TYMS	BUB1B	0.858363852	1.40E-36
UCS	Kinase	TYMS	AURKB	0.858414211	1.37E-36
UCS	Kinase	TYMS	VRK1	0.874557739	1.58E-39
UCS	Kinase	TYMS	PLK4	0.875489477	1.04E-39
UCS	Kinase	TYMS	BUB1	0.875697508	9.47E-40
UCS	Kinase	TYMS	TTK	0.879759988	1.46E-40
UCS	Kinase	TYMS	PLK1	0.892218893	3.03E-43
UCS	TF	TYMS	TFDP2	0.810305879	1.26E-29
UCS	TF	TYMS	TCF7	0.811042876	1.02E-29
UCS	TF	TYMS	MYBL2	0.820844394	5.70E-31
UCS	TF	TYMS	MYB	0.826548742	9.80E-32
UCS	TF	TYMS	GFI1	0.828464087	5.35E-32
UCS	TF	TYMS	E2F8	0.853313755	9.76E-36
UCS	TF	TYMS	FOXM1	0.853664995	8.54E-36
UCS	TF	TYMS	CBX2	0.854185133	7.01E-36
UCS	TF	TYMS	CENPA	0.867154736	3.92E-38
UCS	TF	TYMS	E2F2	0.873855105	2.16E-39
UCS	TF	TYMS	TCF3	0.88285807	3.36E-41
UCS	TSG	TYMS	CDK6	0.80034236	1.97E-28
UCS	TSG	TYMS	H2AFX	0.809173492	1.73E-29
UCS	TSG	TYMS	MME	0.813952461	4.41E-30
UCS	TSG	TYMS	CHEK1	0.833740249	9.69E-33
UCS	TSG	TYMS	EZH2	0.83925088	1.53E-33
UCS	TSG	TYMS	CDKN2C	0.84770709	7.77E-35
UCS	TSG	TYMS	BLM	0.853185668	1.02E-35
UCS	TSG	TYMS	E2F2	0.873855105	2.16E-39
UCS	TSG	TYMS	PTPN2	0.87553249	1.02E-39
UCS	TSG	TYMS	TCF3	0.88285807	3.36E-41
UCS	TSG	TYMS	PLK1	0.892218893	3.03E-43
UVM	Cell metabolism gene	TYMS	RRM2	0.802209473	3.76E-19
UVM	Epifactor	TYMS	CDC6	0.861260616	1.22E-24
UVM	IUPHAR	TYMS	RRM2	0.802209473	3.76E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	TYMS	DHFR	1.84898875578222	0.000120222568511963
KICH	TYMS	TK1	1.29350852013578	0.000429689884185791
KIRC	TYMS	MTHFD1	-1.93638174369857	0.00050811011383314
PRAD	TYMS	DHFR	-1.13763544630147	0.000693018123481419
THCA	TYMS	DUT	-2.59118362009883	0.000711089919756285
KIRC	TYMS	DCTD	-1.38664091523086	0.000866776833311133
ESCA	TYMS	MTHFR	-1.97785499780601	0.0009765625
ESCA	TYMS	DTYMK	-2.19777571313085	0.001953125
KIRP	TYMS	DHFR	1.92771023073588	0.00256496202200651
CHOL	TYMS	MCM2	-5.80203587030152	0.00390625
CHOL	TYMS	SHMT1	-2.63808023305847	0.00390625
COAD	TYMS	TK1	1.28362704461882	0.00561287999153138
ESCA	TYMS	MTHFD1	-3.26939074305335	0.009765625
KIRC	TYMS	DHFR	1.39030277719069	0.0102479184635793
BLCA	TYMS	SHMT1	-2.10321020502746	0.012359619140625
LIHC	TYMS	DHFR	-1.09573134458673	0.0138324207211816
COAD	TYMS	DHFR	1.20329354568984	0.0151321291923523
BRCA	TYMS	MTHFD1	-7.96417208719303	0.0176938185073105
ESCA	TYMS	DHFR	-5.80161159904324	0.0244140625
CHOL	TYMS	DUT	-2.24988995069058	0.02734375
UCEC	TYMS	DHFR	-2.25711809833131	0.03125
BRCA	TYMS	MTHFR	1.60618126989436	0.0312890650643052
KIRC	TYMS	DHFRL1	-1.8058987253221	1.39011934742714e-10
KIRP	TYMS	TK1	-7.93215399967956	1.42422504723072e-05
PRAD	TYMS	SHMT1	1.07461438916689	1.48880035272649e-05
LUAD	TYMS	DHFR	-2.43762628319186	1.73612226412662e-08
PRAD	TYMS	DCTD	1.4432569251244	2.13534004594814e-06
LUAD	TYMS	MTHFD1	-2.15031372279412	2.1660933617938e-09
BRCA	TYMS	MCM2	-5.58924758899809	2.4636673901259e-25
LUAD	TYMS	DTYMK	-5.57815293357196	3.24104467477296e-10
LIHC	TYMS	DUT	-2.57344395745758	3.60241778081952e-05
LUSC	TYMS	DHFR	-2.93769159897646	4.06130956907036e-08
LIHC	TYMS	TK1	-4.9233518069293	4.1313472067693e-09
LUAD	TYMS	MCM2	-4.63163831951408	4.21032885135405e-11
BRCA	TYMS	DTYMK	-1.70208949496289	4.3481420804674e-21
KIRP	TYMS	MCM2	-1.36727379042488	4.97791916131974e-07
KIRP	TYMS	DTYMK	-4.00500910807946	5.24520874023438e-06
THCA	TYMS	TK1	-1.07121661205348	5.3786308950856e-08
LIHC	TYMS	MCM2	-1.99245426511631	5.52349441012722e-09
STAD	TYMS	MTHFD1	-4.08327414989158	8.09784978628159e-07
THCA	TYMS	DHFRL1	-3.07432270098453	8.19249607378906e-08
BLCA	TYMS	MTHFR	-1.09199502480781	9.5367431640625e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with TYMS

SH3GL2, TXNDC17, WDR1, ZFYVE19, SSSCA1, ZFYVE21, UBE2B, IGBP1, PSMA5, UBXN7, UBQLN4, ZRANB2, ATIC, UBE2A, UNK, ATP6V1C1, ATP6V1E1, WDR45B, PGAM1, UBE2K, VPS4B, ADSL, AHCYL1, UBE2C, UBE2M, UFC1, VCAM1, ITGA4, UPF2, EIF5A, DCK, GOT1, MAPK14, PLS3, SBDS, LIMS1, PDCD6, DUT, PHGDH, PPAT, REXO2, SAE1, STMN1, TXN, RPGRIP1L, POC5, POC1B, Tuba3a, CHEK1, PKIG, RTN1, PROSER2, ARHGEF35, ORF70, PHB, NRAS, KRAS, NR2C2, MDP1, nsp15, PABPC1, RBM47, CDC42, BFAR, MARCH3, MARCH4, MARCH6, RNF5, PSD4, NAPG, TANC2, EFHD2, PPP4R1L, PFDN2, PFDN1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
TYMS	chr18	657838	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TYMS	chr18	671433	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant
TYMS	chr18	673086	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
TYMS	PAAD	chr18	670816	670816	C	T	Silent	p.I227I	4
TYMS	HNSC	chr18	670729	670729	C	A	Silent	p.L198L	3
TYMS	KIRP	chr18	662242	662242	A	G	Missense_Mutation	p.R126G	3
TYMS	CESC	chr18	670729	670729	C	G	Silent		3
TYMS	PAAD	chr18	672975	672975	T	G	Missense_Mutation	p.I307S	3
TYMS	COAD	chr18	669136	669136	C	T	Silent	p.D173D	2
TYMS	READ	chr18	672902	672902	C	T	Nonsense_Mutation	p.R283X	2
TYMS	UCEC	chr18	670816	670816	C	T	Silent	p.I227	2
TYMS	BLCA	chr18	670747	670747	G	A	Silent	p.V204V	2
TYMS	SARC	chr18	672908	672908	G	C	Missense_Mutation		2
TYMS	UCS	chr18	672902	672902	C	T	Nonsense_Mutation	p.R283*	2
TYMS	BLCA	chr18	670754	670754	G	A	Missense_Mutation	p.E207K	2
TYMS	LIHC	chr18	671451	671451	G	A	Silent		2
TYMS	SKCM	chr18	672884	672884	C	G	Missense_Mutation	p.P277A	2
TYMS	ESCA	chr18	657939	657939	G	T	Missense_Mutation	p.S66I	2
TYMS	BRCA	chr18	670739	670739	T	C	Missense_Mutation	p.Y202H	2
TYMS	PAAD	chr18	670816	670816	C	T	Silent		2
TYMS	ESCA	chr18	670755	670755	A	G	Missense_Mutation	p.E207G	2
TYMS	LIHC	chr18	662207	662207	C	-	Frame_Shift_Del	p.S114fs	2
TYMS	CESC	chr18	672892	672892	C	G	Silent		2
TYMS	PAAD	chr18	672975	672975	T	G	Missense_Mutation		2
TYMS	ESCA	chr18	671442	671442	G	A	Silent		2
TYMS	LIHC	chr18	662289	662289	T	-	Frame_Shift_Del	p.H141fs	2
TYMS	ESCA	chr18	671442	671442	G	A	Silent	p.L265L	2
TYMS	STAD	chr18	659673	659673	T	C	Missense_Mutation	p.F80L	2
TYMS	PRAD	chr18	670815	670815	T	A	Missense_Mutation	p.I227N	2
TYMS	READ	chr18	669144	669144	G	A	Missense_Mutation	p.R176K	1
TYMS	THYM	chr18	672946	672946	G	T	Missense_Mutation	p.Q297H	1
TYMS	BLCA	chr18	672883	672883	C	T	Silent	p.F276F	1
TYMS	LUAD	chr18	670798	670798	C	T	Silent	p.L221L	1
TYMS	COAD	chr18	670769	670769	C	T	Silent	p.L212L	1
TYMS	LUAD	chr18	662174	662174	C	A	Missense_Mutation	p.S103Y	1
TYMS	COAD	chr18	670771	670771	G	A	Silent	p.L212L	1
TYMS	KIRP	chr18	662242	662242	A	G	Missense_Mutation		1
TYMS	LUAD	chr18	662311	662311	A	G	Missense_Mutation	p.M149V	1
TYMS	COAD	chr18	672957	672957	A	G	Missense_Mutation	p.Y301C	1
TYMS	SARC	chr18	672908	672908	G	C	Missense_Mutation	p.V285L	1
TYMS	BLCA	chr18	672911	672911	G	C	Missense_Mutation	p.E286Q	1
TYMS	MESO	chr18	657887	657887	G	A	Missense_Mutation		1
TYMS	ESCA	chr18	671442	671442	G	A	Silent	p.L265	1
TYMS	LIHC	chr18	671451	671451	G	A	Silent	p.Q268Q	1
TYMS	BLCA	chr18	672950	672950	G	A	Missense_Mutation	p.E299K	1
TYMS	MESO	chr18	657887	657887	G	A	Missense_Mutation	p.D49N	1
TYMS	SKCM	chr18	657755	657755	G	A	Missense_Mutation	p.G5S	1
TYMS	LIHC	chr18	671451	671451	G	A	Splice_Site	p.Q268_splice	1
TYMS	SKCM	chr18	662237	662237	C	T	Missense_Mutation	p.S124F	1
TYMS	SKCM	chr18	672885	672885	C	T	Missense_Mutation	p.P277L	1
TYMS	BLCA	chr18	672883	672883	C	T	Silent		1
TYMS	BLCA	chr18	670747	670747	G	A	Silent		1
TYMS	LIHC	chr18	662215	662215	T	-	Frame_Shift_Del	p.F117fs	1
TYMS	CESC	chr18	670729	670729	C	G	Silent	p.L198	1
TYMS	GBM	chr18	672946	672946	G	A	Missense_Mutation		1
TYMS	THCA	chr18	672874	672874	C	A	Silent		1
TYMS	BLCA	chr18	670754	670754	G	A	Missense_Mutation		1
TYMS	LIHC	chr18	662293	662293	G	-	Frame_Shift_Del	p.G143fs	1
TYMS	CESC	chr18	672892	672892	C	G	Silent	p.L279	1
TYMS	HNSC	chr18	670789	670789	C	G	Missense_Mutation		1
TYMS	THCA	chr18	662209	662209	C	A	Silent		1
TYMS	BLCA	chr18	672911	672911	G	C	Missense_Mutation		1
TYMS	LIHC	chr18	670827	670827	C	-	Frame_Shift_Del	p.A231fs	1

Copy number variation (CNV) of TYMS
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across TYMS
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
43015	N/A	AI361601	CLUL1	chr18	649964	+	TYMS	chr18	657842	+
43015	N/A	BM144222	KLHL3	chr5	136997780	-	TYMS	chr18	672549	+
95679	HNSC	TCGA-CV-6935	TYMS	chr18	659714	+	C18orf56	chr18	649964	-
95679	N/A	AW878210	TYMS	chr18	668859	+	C20orf24	chr20	35240288	+
97391	OV	TCGA-13-0905	TYMS	chr18	662320	+	CARKD	chr13	111274562	+
97170	UCEC	TCGA-KJ-A3U4	TYMS	chr18	662320	+	DYNC2H1	chr11	103228970	+
95679	N/A	BF245161	TYMS	chr18	669173	+	ENOSF1	chr18	670692	+
103056	BLCA	TCGA-XF-A9ST-01A	TYMS	chr18	662320	+	GNAS	chr20	57470667	+
97731	STAD	TCGA-BR-8080-01A	TYMS	chr18	662320	+	PABPC1L	chr20	43561698	+
102865	BRCA	TCGA-BH-A1FC-01A	TYMS	chr18	662320	+	SEPT9	chr17	75483506	+
97632	ESCA	TCGA-IG-A97H	TYMS	chr18	662320	+	SLC12A4	chr16	67997462	-
95679	OV	TCGA-24-2254	TYMS	chr18	662320	+	SUMO1	chr2	203075529	-
95679	N/A	DB026411	TYMS	chr18	661092	+	TRAIP	chr3	49879334	-
95734	OV	TCGA-13-0899	TYMS	chr18	671451	+	USP14	chr18	209970	+
95679	LUSC	TCGA-85-8353-01A	TYMS	chr18	662319	+	YES1	chr18	732964	-
95679	LUSC	TCGA-85-8353-01A	TYMS	chr18	662320	+	YES1	chr18	732965	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	TYMS	0.00109645372599436	0.031
SARC	TYMS	0.00122736845791849	0.033
HNSC	TYMS	0.00282173709676868	0.073
LUAD	TYMS	0.00567229742535511	0.14
KIRC	TYMS	0.00815209850805445	0.2
BLCA	TYMS	0.0208361792820223	0.48
ESCA	TYMS	0.0279323619514524	0.61
LAML	TYMS	0.0315959483984835	0.66
PAAD	TYMS	0.0361881068685209	0.72

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	TYMS	0.0156704733252761	0.39
STAD	TYMS	0.00869806463408904	0.23
LUSC	TYMS	0.00798758446309935	0.22
LGG	TYMS	1.04730638547104e-06	3.5e-05
BRCA	TYMS	0.000212502863490815	0.0064
PRAD	TYMS	9.02985123841731e-05	0.0028
ESCA	TYMS	2.17899239311569e-05	7e-04
PCPG	TYMS	0.0102905923859055	0.27
THYM	TYMS	0.000665682335601459	0.019

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P04818	DB00293	Raltitrexed	Inhibitor	Small molecule	Approved\|Investigational
P04818	DB00322	Floxuridine		Small molecule	Approved
P04818	DB00432	Trifluridine	Inhibitor	Small molecule	Approved\|Investigational
P04818	DB00441	Gemcitabine	Inhibitor	Small molecule	Approved
P04818	DB00544	Fluorouracil	Other/unknown	Small molecule	Approved
P04818	DB00563	Methotrexate	Inhibitor	Small molecule	Approved
P04818	DB01101	Capecitabine	Inhibitor	Small molecule	Approved\|Investigational
P04818	DB01643	Thymidine monophosphate		Small molecule	Experimental
P04818	DB03541	10-Propargyl-5,8-Dideazafolic Acid		Small molecule	Experimental
P04818	DB03800	Deoxyuridine monophosphate		Small molecule	Experimental
P04818	DB04530	S,S-(2-Hydroxyethyl)Thiocysteine		Small molecule	Experimental
P04818	DB05116	Thymectacin		Small molecule	Investigational
P04818	DB05308	ANX-510		Small molecule	Investigational
P04818	DB05457	OSI-7904L		Small molecule	Investigational
P04818	DB06813	Pralatrexate	Inhibitor	Small molecule	Approved\|Investigational
P04818	DB07577	2,4-Diamino-5-phenyl-6-ethylpyrimidine		Small molecule	Experimental
P04818	DB08478	N-[2-Chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide		Small molecule	Experimental
P04818	DB08479	N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide		Small molecule	Experimental
P04818	DB08734	6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE		Small molecule	Experimental
P04818	DB09256	Tegafur	Inhibitor	Small molecule	Approved\|Investigational
P04818	DB09327	Tegafur-uracil	Antagonist	Small molecule	Approved\|Investigational
P04818	DB00293	Raltitrexed	Inhibitor
P04818	DB00322	Floxuridine
P04818	DB00432	Trifluridine	Inhibitor
P04818	DB00441	Gemcitabine	Inhibitor
P04818	DB00544	Fluorouracil	Other/unknown
P04818	DB00563	Methotrexate	Inhibitor
P04818	DB01101	Capecitabine	Inhibitor
P04818	DB01643	Thymidine monophosphate
P04818	DB03541	10-Propargyl-5,8-Dideazafolic Acid
P04818	DB03800	Deoxyuridine monophosphate
P04818	DB04530	S,S-(2-Hydroxyethyl)Thiocysteine
P04818	DB05116	Thymectacin
P04818	DB05308	ANX-510
P04818	DB05457	OSI-7904L
P04818	DB06813	Pralatrexate	Inhibitor
P04818	DB07577	2,4-Diamino-5-phenyl-6-ethylpyrimidine
P04818	DB08478	N-[2-Chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide
P04818	DB08479	N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide
P04818	DB08734	6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE
P04818	DB09256	Tegafur	Inhibitor
P04818	DB09327	Tegafur-uracil	Antagonist

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0009402	Colorectal Carcinoma	11	CTD_human
C0007102	Malignant tumor of colon	6	CTD_human
C0024623	Malignant neoplasm of stomach	4	CTD_human
C1708349	Hereditary Diffuse Gastric Cancer	4	CTD_human
C0006142	Malignant neoplasm of breast	3	CTD_human
C0678222	Breast Carcinoma	3	CTD_human
C1257931	Mammary Neoplasms, Human	3	CTD_human
C4704874	Mammary Carcinoma, Human	3	CTD_human
C0242379	Malignant neoplasm of lung	2	CTD_human
C2239176	Liver carcinoma	2	CTD_human
C0002871	Anemia	1	CTD_human
C0007113	Rectal Carcinoma	1	CTD_human
C0007137	Squamous cell carcinoma	1	CTD_human
C0008924	Cleft upper lip	1	CTD_human
C0008925	Cleft Palate	1	CTD_human
C0024301	Lymphoma, Follicular	1	CTD_human
C0024302	Reticulosarcoma	1	CTD_human
C0024304	Lymphoma, Mixed-Cell	1	CTD_human
C0024305	Lymphoma, Non-Hodgkin	1	CTD_human
C0024306	Lymphoma, Undifferentiated	1	CTD_human
C0030297	Pancreatic Neoplasm	1	CTD_human
C0079740	High Grade Lymphoma (neoplasm)	1	CTD_human
C0079741	Lymphoma, Intermediate-Grade	1	CTD_human
C0079745	Lymphoma, Large-Cell, Follicular	1	CTD_human
C0079747	Low Grade Lymphoma (neoplasm)	1	CTD_human
C0079757	Diffuse Mixed-Cell Lymphoma	1	CTD_human
C0079758	Lymphoma, Mixed-Cell, Follicular	1	CTD_human
C0079765	Lymphoma, Small Cleaved-Cell, Follicular	1	CTD_human
C0079770	Lymphoma, Small Noncleaved-Cell	1	CTD_human
C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
C0153349	Malignant neoplasm of tongue	1	CTD_human
C0278996	Malignant Head and Neck Neoplasm	1	CTD_human
C0346647	Malignant neoplasm of pancreas	1	CTD_human
C0376358	Malignant neoplasm of prostate	1	CTD_human
C0746787	Cancer of Neck	1	CTD_human
C0751075	Cancer of Digestive System	1	CTD_human
C0751177	Cancer of Head	1	CTD_human
C0919267	ovarian neoplasm	1	CTD_human
C1140680	Malignant neoplasm of ovary	1	CTD_human
C1837218	Cleft palate, isolated	1	CTD_human
C1956130	Lymphoma, Follicular, Grade 1	1	CTD_human
C1956131	Lymphoma, Follicular, Grade 3	1	CTD_human
C1956132	Lymphoma, Follicular, Grade 2	1	CTD_human
C3714542	Lymphoma, Diffuse	1	CTD_human
C4721532	Lymphoma, Non-Hodgkin, Familial	1	CTD_human