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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EIF4H (NCBI Gene ID:7458)

Gene Summary

Gene Summary

Gene Information	Gene Name: EIF4H
	Gene ID: 7458
	Gene Symbol	EIF4H
	Gene ID	7458
	Gene Name	eukaryotic translation initiation factor 4H
	Synonyms	WBSCR1\|WSCR1\|eIF-4H
	Cytomap	7q11.23
	Type of Gene	protein-coding
	Description	eukaryotic translation initiation factor 4HWilliams-Beuren syndrome chromosome region 1
	Modification date	20200313
	UniProtAcc	Q15056

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0002181	Cytoplasmic translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EIF4H	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'EIF4H[title] AND translation [title] AND human.'

Gene	Title	PMID
EIF4H	A bimodal switch in global protein translation coupled to eIF4H relocalisation during advancing cell-cell transmission of herpes simplex virus	30028874

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000265753	73604576	73604636	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000265753	73604576	73604636	2696	549	608	248	136	156

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q15056	136	156	2	248	Chain	ID=PRO_0000081619;Note=Eukaryotic translation initiation factor 4H
Q15056	136	156	137	157	Region	Note=HHV-1 Vhs binding site
Q15056	136	156	136	136	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9WUK2
Q15056	136	156	137	156	Alternative sequence	ID=VSP_005799;Note=In isoform Short. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:7584026;Dbxref=PMID:14702039,PMID:15489334,PMID:7584026

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
THCA	EIF4H	-2.66018618082178	0.00297675159343486

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EIF4H (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
THYM	Cell metabolism gene	EIF4H	SUCLA2	0.802910132	9.84E-29
THYM	Cell metabolism gene	EIF4H	AASDHPPT	0.806885059	3.29E-29
THYM	Cell metabolism gene	EIF4H	POLR2B	0.809120745	1.76E-29
THYM	Cell metabolism gene	EIF4H	MTM1	0.81609506	2.35E-30
THYM	Cell metabolism gene	EIF4H	HSD17B4	0.817659783	1.48E-30
THYM	Cell metabolism gene	EIF4H	XRN2	0.824632537	1.78E-31
THYM	Cell metabolism gene	EIF4H	NCOA6	0.825864046	1.21E-31
THYM	Cell metabolism gene	EIF4H	MED17	0.835577004	5.27E-33
THYM	Cell metabolism gene	EIF4H	TRMT11	0.853952385	7.66E-36
THYM	Cell metabolism gene	EIF4H	RQCD1	0.855721074	3.90E-36
THYM	Cell metabolism gene	EIF4H	MUT	0.858184952	1.50E-36
THYM	Cell metabolism gene	EIF4H	PIK3R4	0.864971176	9.75E-38
THYM	Cell metabolism gene	EIF4H	PNPLA8	0.865618037	7.46E-38
THYM	Cell metabolism gene	EIF4H	CDK8	0.86770747	3.11E-38
THYM	Cell metabolism gene	EIF4H	BCKDHB	0.869480815	1.46E-38
THYM	Cell metabolism gene	EIF4H	PIP5K1A	0.8759643	8.40E-40
THYM	CGC	EIF4H	NSD1	0.802095455	1.23E-28
THYM	CGC	EIF4H	STAG1	0.81488151	3.36E-30
THYM	CGC	EIF4H	BCOR	0.817473026	1.57E-30
THYM	CGC	EIF4H	NFE2L2	0.822418238	3.53E-31
THYM	CGC	EIF4H	MAPK1	0.836927719	3.35E-33
THYM	CGC	EIF4H	FUBP1	0.846712053	1.11E-34
THYM	CGC	EIF4H	MLLT10	0.864361915	1.25E-37
THYM	Epifactor	EIF4H	NSD1	0.802095455	1.23E-28
THYM	Epifactor	EIF4H	JMJD1C	0.802810751	1.01E-28
THYM	Epifactor	EIF4H	HCFC2	0.80336947	8.68E-29
THYM	Epifactor	EIF4H	BRD2	0.804884218	5.73E-29
THYM	Epifactor	EIF4H	GLYR1	0.806461234	3.70E-29
THYM	Epifactor	EIF4H	ATXN7L3	0.807209482	3.01E-29
THYM	Epifactor	EIF4H	TADA1	0.807287962	2.94E-29
THYM	Epifactor	EIF4H	ZHX1	0.808642142	2.01E-29
THYM	Epifactor	EIF4H	SMARCAD1	0.809837502	1.44E-29
THYM	Epifactor	EIF4H	KDM3B	0.816526416	2.07E-30
THYM	Epifactor	EIF4H	BCOR	0.817473026	1.57E-30
THYM	Epifactor	EIF4H	INO80D	0.817688383	1.47E-30
THYM	Epifactor	EIF4H	CTR9	0.820379027	6.56E-31
THYM	Epifactor	EIF4H	EPC1	0.820872687	5.65E-31
THYM	Epifactor	EIF4H	KDM4A	0.823366669	2.64E-31
THYM	Epifactor	EIF4H	NCOA6	0.825864046	1.21E-31
THYM	Epifactor	EIF4H	ZRANB3	0.826326564	1.05E-31
THYM	Epifactor	EIF4H	ZNF217	0.839563986	1.37E-33
THYM	Epifactor	EIF4H	TAF2	0.849662108	3.81E-35
THYM	Epifactor	EIF4H	MLLT10	0.864361915	1.25E-37
THYM	Epifactor	EIF4H	ADNP	0.878880193	2.20E-40
THYM	IUPHAR	EIF4H	NSD1	0.802095455	1.23E-28
THYM	IUPHAR	EIF4H	JMJD1C	0.802810751	1.01E-28
THYM	IUPHAR	EIF4H	NEK4	0.802946697	9.75E-29
THYM	IUPHAR	EIF4H	BRD2	0.804884218	5.73E-29
THYM	IUPHAR	EIF4H	KDM3B	0.816526416	2.07E-30
THYM	IUPHAR	EIF4H	NR2C2	0.820929988	5.55E-31
THYM	IUPHAR	EIF4H	NFE2L2	0.822418238	3.53E-31
THYM	IUPHAR	EIF4H	KDM4A	0.823366669	2.64E-31
THYM	IUPHAR	EIF4H	TNKS2	0.83604669	4.51E-33
THYM	IUPHAR	EIF4H	MAPK1	0.836927719	3.35E-33
THYM	IUPHAR	EIF4H	PIK3R4	0.864971176	9.75E-38
THYM	IUPHAR	EIF4H	CDK8	0.86770747	3.11E-38
THYM	IUPHAR	EIF4H	MAPK8	0.874555228	1.58E-39
THYM	IUPHAR	EIF4H	PIP5K1A	0.8759643	8.40E-40
THYM	Kinase	EIF4H	NEK4	0.802946697	9.75E-29
THYM	Kinase	EIF4H	BRD2	0.804884218	5.73E-29
THYM	Kinase	EIF4H	MAPK1	0.836927719	3.35E-33
THYM	Kinase	EIF4H	PIK3R4	0.864971176	9.75E-38
THYM	Kinase	EIF4H	CDK8	0.86770747	3.11E-38
THYM	Kinase	EIF4H	MAPK8	0.874555228	1.58E-39
THYM	TF	EIF4H	FOXJ3	0.804385192	6.58E-29
THYM	TF	EIF4H	ZNF354B	0.805366302	5.02E-29
THYM	TF	EIF4H	ZNF773	0.806061245	4.14E-29
THYM	TF	EIF4H	GLYR1	0.806461234	3.70E-29
THYM	TF	EIF4H	ZNF430	0.807709385	2.62E-29
THYM	TF	EIF4H	ZHX1	0.808642142	2.01E-29
THYM	TF	EIF4H	ZNF77	0.810288303	1.26E-29
THYM	TF	EIF4H	RBAK	0.811420096	9.15E-30
THYM	TF	EIF4H	ZNF12	0.811755884	8.31E-30
THYM	TF	EIF4H	MEF2A	0.812242066	7.22E-30
THYM	TF	EIF4H	ZNF264	0.814137383	4.18E-30
THYM	TF	EIF4H	SP3	0.814589091	3.66E-30
THYM	TF	EIF4H	ZNF200	0.815680869	2.66E-30
THYM	TF	EIF4H	ZNF75D	0.816100882	2.35E-30
THYM	TF	EIF4H	ZNF146	0.816543488	2.06E-30
THYM	TF	EIF4H	ZNF543	0.819576806	8.35E-31
THYM	TF	EIF4H	NR2C2	0.820929988	5.55E-31
THYM	TF	EIF4H	ZNF599	0.821978056	4.04E-31
THYM	TF	EIF4H	NFE2L2	0.822418238	3.53E-31
THYM	TF	EIF4H	ZNF280B	0.824248515	2.01E-31
THYM	TF	EIF4H	ZNF765	0.825407819	1.40E-31
THYM	TF	EIF4H	CXXC5	0.828972076	4.55E-32
THYM	TF	EIF4H	ZNF680	0.829722297	3.58E-32
THYM	TF	EIF4H	ZFP30	0.829952655	3.32E-32
THYM	TF	EIF4H	ZNF487	0.83232555	1.54E-32
THYM	TF	EIF4H	ZNF468	0.835368001	5.65E-33
THYM	TF	EIF4H	ZNF217	0.839563986	1.37E-33
THYM	TF	EIF4H	ZNF689	0.841811339	6.31E-34
THYM	TF	EIF4H	ZNF17	0.842756442	4.54E-34
THYM	TF	EIF4H	ZBTB43	0.847110949	9.64E-35
THYM	TF	EIF4H	ZNF304	0.858079336	1.56E-36
THYM	TF	EIF4H	ZNF28	0.861313849	4.33E-37
THYM	TF	EIF4H	ZNF627	0.8657704	7.00E-38
THYM	TF	EIF4H	ZNF136	0.870539213	9.26E-39
THYM	TF	EIF4H	TOPORS	0.875265252	1.15E-39
THYM	TF	EIF4H	ZNF420	0.875951054	8.45E-40
THYM	TF	EIF4H	ZNF776	0.876946745	5.37E-40
THYM	TF	EIF4H	ZNF567	0.877901138	3.47E-40
THYM	TF	EIF4H	ADNP	0.878880193	2.20E-40
THYM	TSG	EIF4H	KDM3B	0.816526416	2.07E-30
THYM	TSG	EIF4H	NR2C2	0.820929988	5.55E-31
THYM	TSG	EIF4H	CXXC5	0.828972076	4.55E-32
THYM	TSG	EIF4H	KRIT1	0.848349325	6.15E-35
THYM	TSG	EIF4H	RCHY1	0.864959695	9.80E-38
THYM	TSG	EIF4H	TOPORS	0.875265252	1.15E-39
UCS	Cell metabolism gene	EIF4H	SUCLA2	0.802910132	9.84E-29
UCS	Cell metabolism gene	EIF4H	AASDHPPT	0.806885059	3.29E-29
UCS	Cell metabolism gene	EIF4H	POLR2B	0.809120745	1.76E-29
UCS	Cell metabolism gene	EIF4H	MTM1	0.81609506	2.35E-30
UCS	Cell metabolism gene	EIF4H	HSD17B4	0.817659783	1.48E-30
UCS	Cell metabolism gene	EIF4H	XRN2	0.824632537	1.78E-31
UCS	Cell metabolism gene	EIF4H	NCOA6	0.825864046	1.21E-31
UCS	Cell metabolism gene	EIF4H	MED17	0.835577004	5.27E-33
UCS	Cell metabolism gene	EIF4H	TRMT11	0.853952385	7.66E-36
UCS	Cell metabolism gene	EIF4H	RQCD1	0.855721074	3.90E-36
UCS	Cell metabolism gene	EIF4H	MUT	0.858184952	1.50E-36
UCS	Cell metabolism gene	EIF4H	PIK3R4	0.864971176	9.75E-38
UCS	Cell metabolism gene	EIF4H	PNPLA8	0.865618037	7.46E-38
UCS	Cell metabolism gene	EIF4H	CDK8	0.86770747	3.11E-38
UCS	Cell metabolism gene	EIF4H	BCKDHB	0.869480815	1.46E-38
UCS	Cell metabolism gene	EIF4H	PIP5K1A	0.8759643	8.40E-40
UCS	CGC	EIF4H	NSD1	0.802095455	1.23E-28
UCS	CGC	EIF4H	STAG1	0.81488151	3.36E-30
UCS	CGC	EIF4H	BCOR	0.817473026	1.57E-30
UCS	CGC	EIF4H	NFE2L2	0.822418238	3.53E-31
UCS	CGC	EIF4H	MAPK1	0.836927719	3.35E-33
UCS	CGC	EIF4H	FUBP1	0.846712053	1.11E-34
UCS	CGC	EIF4H	MLLT10	0.864361915	1.25E-37
UCS	Epifactor	EIF4H	NSD1	0.802095455	1.23E-28
UCS	Epifactor	EIF4H	JMJD1C	0.802810751	1.01E-28
UCS	Epifactor	EIF4H	HCFC2	0.80336947	8.68E-29
UCS	Epifactor	EIF4H	BRD2	0.804884218	5.73E-29
UCS	Epifactor	EIF4H	GLYR1	0.806461234	3.70E-29
UCS	Epifactor	EIF4H	ATXN7L3	0.807209482	3.01E-29
UCS	Epifactor	EIF4H	TADA1	0.807287962	2.94E-29
UCS	Epifactor	EIF4H	ZHX1	0.808642142	2.01E-29
UCS	Epifactor	EIF4H	SMARCAD1	0.809837502	1.44E-29
UCS	Epifactor	EIF4H	KDM3B	0.816526416	2.07E-30
UCS	Epifactor	EIF4H	BCOR	0.817473026	1.57E-30
UCS	Epifactor	EIF4H	INO80D	0.817688383	1.47E-30
UCS	Epifactor	EIF4H	CTR9	0.820379027	6.56E-31
UCS	Epifactor	EIF4H	EPC1	0.820872687	5.65E-31
UCS	Epifactor	EIF4H	KDM4A	0.823366669	2.64E-31
UCS	Epifactor	EIF4H	NCOA6	0.825864046	1.21E-31
UCS	Epifactor	EIF4H	ZRANB3	0.826326564	1.05E-31
UCS	Epifactor	EIF4H	ZNF217	0.839563986	1.37E-33
UCS	Epifactor	EIF4H	TAF2	0.849662108	3.81E-35
UCS	Epifactor	EIF4H	MLLT10	0.864361915	1.25E-37
UCS	Epifactor	EIF4H	ADNP	0.878880193	2.20E-40
UCS	IUPHAR	EIF4H	NSD1	0.802095455	1.23E-28
UCS	IUPHAR	EIF4H	JMJD1C	0.802810751	1.01E-28
UCS	IUPHAR	EIF4H	NEK4	0.802946697	9.75E-29
UCS	IUPHAR	EIF4H	BRD2	0.804884218	5.73E-29
UCS	IUPHAR	EIF4H	KDM3B	0.816526416	2.07E-30
UCS	IUPHAR	EIF4H	NR2C2	0.820929988	5.55E-31
UCS	IUPHAR	EIF4H	NFE2L2	0.822418238	3.53E-31
UCS	IUPHAR	EIF4H	KDM4A	0.823366669	2.64E-31
UCS	IUPHAR	EIF4H	TNKS2	0.83604669	4.51E-33
UCS	IUPHAR	EIF4H	MAPK1	0.836927719	3.35E-33
UCS	IUPHAR	EIF4H	PIK3R4	0.864971176	9.75E-38
UCS	IUPHAR	EIF4H	CDK8	0.86770747	3.11E-38
UCS	IUPHAR	EIF4H	MAPK8	0.874555228	1.58E-39
UCS	IUPHAR	EIF4H	PIP5K1A	0.8759643	8.40E-40
UCS	Kinase	EIF4H	NEK4	0.802946697	9.75E-29
UCS	Kinase	EIF4H	BRD2	0.804884218	5.73E-29
UCS	Kinase	EIF4H	MAPK1	0.836927719	3.35E-33
UCS	Kinase	EIF4H	PIK3R4	0.864971176	9.75E-38
UCS	Kinase	EIF4H	CDK8	0.86770747	3.11E-38
UCS	Kinase	EIF4H	MAPK8	0.874555228	1.58E-39
UCS	TF	EIF4H	FOXJ3	0.804385192	6.58E-29
UCS	TF	EIF4H	ZNF354B	0.805366302	5.02E-29
UCS	TF	EIF4H	ZNF773	0.806061245	4.14E-29
UCS	TF	EIF4H	GLYR1	0.806461234	3.70E-29
UCS	TF	EIF4H	ZNF430	0.807709385	2.62E-29
UCS	TF	EIF4H	ZHX1	0.808642142	2.01E-29
UCS	TF	EIF4H	ZNF77	0.810288303	1.26E-29
UCS	TF	EIF4H	RBAK	0.811420096	9.15E-30
UCS	TF	EIF4H	ZNF12	0.811755884	8.31E-30
UCS	TF	EIF4H	MEF2A	0.812242066	7.22E-30
UCS	TF	EIF4H	ZNF264	0.814137383	4.18E-30
UCS	TF	EIF4H	SP3	0.814589091	3.66E-30
UCS	TF	EIF4H	ZNF200	0.815680869	2.66E-30
UCS	TF	EIF4H	ZNF75D	0.816100882	2.35E-30
UCS	TF	EIF4H	ZNF146	0.816543488	2.06E-30
UCS	TF	EIF4H	ZNF543	0.819576806	8.35E-31
UCS	TF	EIF4H	NR2C2	0.820929988	5.55E-31
UCS	TF	EIF4H	ZNF599	0.821978056	4.04E-31
UCS	TF	EIF4H	NFE2L2	0.822418238	3.53E-31
UCS	TF	EIF4H	ZNF280B	0.824248515	2.01E-31
UCS	TF	EIF4H	ZNF765	0.825407819	1.40E-31
UCS	TF	EIF4H	CXXC5	0.828972076	4.55E-32
UCS	TF	EIF4H	ZNF680	0.829722297	3.58E-32
UCS	TF	EIF4H	ZFP30	0.829952655	3.32E-32
UCS	TF	EIF4H	ZNF487	0.83232555	1.54E-32
UCS	TF	EIF4H	ZNF468	0.835368001	5.65E-33
UCS	TF	EIF4H	ZNF217	0.839563986	1.37E-33
UCS	TF	EIF4H	ZNF689	0.841811339	6.31E-34
UCS	TF	EIF4H	ZNF17	0.842756442	4.54E-34
UCS	TF	EIF4H	ZBTB43	0.847110949	9.64E-35
UCS	TF	EIF4H	ZNF304	0.858079336	1.56E-36
UCS	TF	EIF4H	ZNF28	0.861313849	4.33E-37
UCS	TF	EIF4H	ZNF627	0.8657704	7.00E-38
UCS	TF	EIF4H	ZNF136	0.870539213	9.26E-39
UCS	TF	EIF4H	TOPORS	0.875265252	1.15E-39
UCS	TF	EIF4H	ZNF420	0.875951054	8.45E-40
UCS	TF	EIF4H	ZNF776	0.876946745	5.37E-40
UCS	TF	EIF4H	ZNF567	0.877901138	3.47E-40
UCS	TF	EIF4H	ADNP	0.878880193	2.20E-40
UCS	TSG	EIF4H	KDM3B	0.816526416	2.07E-30
UCS	TSG	EIF4H	NR2C2	0.820929988	5.55E-31
UCS	TSG	EIF4H	CXXC5	0.828972076	4.55E-32
UCS	TSG	EIF4H	KRIT1	0.848349325	6.15E-35
UCS	TSG	EIF4H	RCHY1	0.864959695	9.80E-38
UCS	TSG	EIF4H	TOPORS	0.875265252	1.15E-39

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUAD	EIF4H	EIF4A2	1.8359785836448	0.000162905479402723
KICH	EIF4H	EIF4EBP3	1.9759816418175	0.00102710723876953
BRCA	EIF4H	EIF4G2	1.33801911881742	0.0018433651637361
BRCA	EIF4H	EIF4EBP3	-1.22871675560918	0.00216137798426823
BRCA	EIF4H	EIF4G3	1.34206807761848	0.00309822300858815
KIRP	EIF4H	EIF4EBP3	1.30969388002957	0.0038655917160213
STAD	EIF4H	EIF4G2	-4.30902559301167	0.0050255935639143
KICH	EIF4H	EIF4G1	-1.46656081150743	0.00612920522689819
ESCA	EIF4H	EIF4EBP3	2.98324688612886	0.013671875
ESCA	EIF4H	EIF4A1	-1.24538073199285	0.0419921875
THCA	EIF4H	EIF4G3	-1.00361616225016	1.40000643717562e-05
LUAD	EIF4H	EIF4G3	-4.21879885884405	2.22325471114907e-07
BRCA	EIF4H	EIF4B	-2.16032742029696	2.35556737304054e-22
KIRC	EIF4H	EIF4EBP3	3.34630238884032	2.66680331214666e-11
LUSC	EIF4H	EIF4G3	-4.43634473815109	3.64325144746635e-05
KICH	EIF4H	EIF4E	1.61675210562671	6.55651092529297e-06
KIRC	EIF4H	EIF4B	1.14997140510474	7.59366366705366e-09
KICH	EIF4H	EIF4A1	1.14485583309571	8.16583633422851e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EIF4H

C11orf68, AI837181, EIF4A1, EIF4E, EIF3A, SYNCRIP, TRA2B, HNRNPA0, HNRNPDL, SRSF3, EIF4G2, RBMS2, NUDT21, PUF60, MRPL9, DGKQ, ICT1, MRPL44, FN1, AHSA1, CASP7, EEF2, EIF5, G6PD, GINS2, GLA, MAT2B, RPS6KA1, NDRG1, PGD, LNX1, MOV10, CUL7, UNK, ATP1B1, EWSR1, FUS, GART, GNAS, HNRNPL, IRF2BP2, KIAA0368, LDHB, PFAS, PSPC1, FAM98B, KDM3A, LIX1L, MESDC2, MRPS36, PAFAH1B2, RAVER1, NTRK1, HIST1H2BG, Csde1, U2AF2, CDH1, G3BP1, TGFB1, TNIP2, MYC, BICD2, nsp9, DLG3, SPG21, PICK1, DDIT4L, FBXO17, HCVgp1, PRNP, HNRNPH1, Rnf183, BRD4, Apc2, BKRF1, RIN3, DNAJB4, DNAJA3, DNAJB11, SEC63, MAPRE1, PRPH, RPS20, TERF2IP, VIM, NAA40, BTF3, TRIM26,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EIF4H	KIRP	chr7	73601993	73601993	A	G	Missense_Mutation	p.T38A	4
EIF4H	COAD	chr7	73604022	73604022	C	T	Silent	p.F89F	3
EIF4H	ESCA	chr7	73588738	73588738	G	C	Missense_Mutation	p.D9H	3
EIF4H	PRAD	chr7	73604629	73604629	C	T	Silent	p.F154F	3
EIF4H	CESC	chr7	73602092	73602092	C	T	Missense_Mutation		3
EIF4H	BLCA	chr7	73588773	73588773	G	A	Splice_Site		2
EIF4H	UCS	chr7	73588769	73588769	G	A	Missense_Mutation	p.R19K	2
EIF4H	COAD	chr7	73602045	73602045	A	G	Missense_Mutation	p.Q55R	2
EIF4H	LIHC	chr7	73609622	73609622	A	-	Frame_Shift_Del	p.Q244fs	2
EIF4H	LUAD	chr7	73588723	73588723	T	G	Missense_Mutation	p.F4V	2
EIF4H	ESCA	chr7	73604164	73604164	C	T	Missense_Mutation	p.R109W	2
EIF4H	SKCM	chr7	73609501	73609501	G	C	Missense_Mutation	p.E204Q	2
EIF4H	SKCM	chr7	73604023	73604023	G	A	Missense_Mutation	p.D90N	2
EIF4H	PAAD	chr7	73609630	73609630	C	T	Nonsense_Mutation	p.Q247*	2
EIF4H	LIHC	chr7	73609125	73609125	G	T	Missense_Mutation		2
EIF4H	BRCA	chr7	73609623	73609623	A	G	Silent	p.Q244	2
EIF4H	CESC	chr7	73609171	73609171	C	T	Silent		2
EIF4H	BLCA	chr7	73604637	73604637	G	A	Splice_Site		2
EIF4H	UCEC	chr7	73604022	73604022	C	T	Silent	p.F89	2
EIF4H	STAD	chr7	73609551	73609551	G	A	Silent	p.T220T	2
EIF4H	LIHC	chr7	73609125	73609125	G	T	Missense_Mutation	p.R175L	2
EIF4H	UCEC	chr7	73609149	73609149	G	A	Missense_Mutation	p.R183H	2
EIF4H	LIHC	chr7	73602087	73602087	G	T	Missense_Mutation	p.S69I	1
EIF4H	SARC	chr7	73604158	73604158	G	T	Missense_Mutation		1
EIF4H	HNSC	chr7	73609192	73609192	C	T	Silent	p.F197F	1
EIF4H	STAD	chr7	73604598	73604598	C	A	Missense_Mutation	p.S144Y	1
EIF4H	BLCA	chr7	73609545	73609545	C	T	Silent		1
EIF4H	SARC	chr7	73609499	73609499	A	-	Frame_Shift_Del		1
EIF4H	HNSC	chr7	73604163	73604171	TCGGTCACT	-	In_Frame_Del	p.DRSL108del	1
EIF4H	STAD	chr7	73604058	73604058	C	T	Silent	p.Y101Y	1
EIF4H	BLCA	chr7	73604598	73604598	C	T	Missense_Mutation		1
EIF4H	LIHC	chr7	73604619	73604619	G	-	Frame_Shift_Del	p.R151fs	1
EIF4H	SARC	chr7	73609499	73609499	A	-	Splice_Site	p.E204_splice	1
EIF4H	HNSC	chr7	73604163	73604171	TCGGTCACT	-	In_Frame_Del	p.RSL109del	1
EIF4H	THCA	chr7	73604618	73604618	C	A	Silent		1
EIF4H	BLCA	chr7	73602031	73602031	T	G	Silent	p.P50P	1
EIF4H	KIRC	chr7	73609131	73609132	-	C	Frame_Shift_Ins	p.A177fs	1
EIF4H	THCA	chr7	73609165	73609165	T	C	Silent	p.P188P	1
EIF4H	BLCA	chr7	73609545	73609545	C	T	Silent	p.V218V	1
EIF4H	PAAD	chr7	73609630	73609630	C	T	Nonsense_Mutation	p.Q247X	1
EIF4H	ESCA	chr7	73588738	73588738	G	C	Missense_Mutation		1
EIF4H	THYM	chr7	73602092	73602092	C	T	Missense_Mutation	p.R71W	1
EIF4H	BLCA	chr7	73604598	73604598	C	T	Missense_Mutation	p.S144F	1
EIF4H	GBM	chr7	73601967	73601967	G	T	Missense_Mutation	p.G29V	1
EIF4H	SKCM	chr7	73602004	73602004	C	A	Silent	p.P41P	1
EIF4H	KIRP	chr7	73601993	73601993	A	G	Missense_Mutation		1
EIF4H	UCEC	chr7	73605561	73605561	G	A	RNA		1
EIF4H	UCEC	chr7	73604014	73604014	G	T	Missense_Mutation	p.V87L	1
EIF4H	BLCA	chr7	73588773	73588773	G	A	Splice_Site	p.G20_splice	1
EIF4H	PAAD	chr7	73609630	73609630	C	T	Missense_Mutation		1
EIF4H	GBM	chr7	73609098	73609098	G	A	Missense_Mutation	p.R166K	1
EIF4H	SKCM	chr7	73604003	73604003	G	A	Splice_Site	p.G83_splice	1
EIF4H	UCEC	chr7	73609131	73609132	-	C	Frame_Shift_Ins	p.G177fs	1
EIF4H	GBM	chr7	73609098	73609098	G	A	Missense_Mutation		1
EIF4H	SKCM	chr7	73604036	73604036	C	T	Missense_Mutation	p.S94F	1
EIF4H	LIHC	chr7	73602087	73602087	G	T	Missense_Mutation		1
EIF4H	UCEC	chr7	73609132	73609132	C	-	Frame_Shift_Del	p.G177fs	1
EIF4H	PRAD	chr7	73588718	73588718	C	T	Missense_Mutation	p.A2V	1
EIF4H	HNSC	chr7	73604163	73604171	TCGGTCACT	-	In_Frame_Del		1
EIF4H	SKCM	chr7	73601971	73601971	C	T	Silent	p.S30S	1
EIF4H	LIHC	chr7	73588659	73588659	A	G	Missense_Mutation		1
EIF4H	PRAD	chr7	73609077	73609077	G	T	Missense_Mutation	p.R159M	1
EIF4H	HNSC	chr7	73609192	73609192	C	T	Silent		1
EIF4H	BLCA	chr7	73602031	73602031	T	G	Silent		1
EIF4H	CESC	chr7	73609171	73609171	C	T	Silent	p.L190	1
EIF4H	READ	chr7	73609538	73609538	G	A	Missense_Mutation	p.R216Q	1
EIF4H	HNSC	chr7	73604022	73604022	C	T	Silent		1
EIF4H	STAD	chr7	73604186	73604186	C	A	Missense_Mutation	p.A116E	1

Copy number variation (CNV) of EIF4H
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EIF4H
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
78420	N/A	BE770560	CRYZL1	chr21	34975789	+	EIF4H	chr7	73610721	+
26071	ACC	TCGA-OR-A5J8-01A	EIF4H	chr7	73588771	+	AARS2	chr6	44279999	-
26071	ACC	TCGA-OR-A5J8-01A	EIF4H	chr7	73588772	+	AARS2	chr6	44280000	-
83690	LUAD	TCGA-38-4630	EIF4H	chr7	73604248	+	ELN	chr7	73449693	+
83690	LUAD	TCGA-38-4630	EIF4H	chr7	73604636	+	ELN	chr7	73449693	+
83690	LUAD	TCGA-38-4630-01A	EIF4H	chr7	73604247	+	ELN	chr7	73449693	+
83690	LUAD	TCGA-38-4630-01A	EIF4H	chr7	73604248	+	ELN	chr7	73449694	+
83690	LUAD	TCGA-38-4630-01A	EIF4H	chr7	73604635	+	ELN	chr7	73449693	+
83690	LUAD	TCGA-38-4630-01A	EIF4H	chr7	73604636	+	ELN	chr7	73449694	+
98966	GBM	TCGA-06-2557	EIF4H	chr7	73604248	+	GTF2I	chr7	74173109	+
98966	GBM	TCGA-06-2557	EIF4H	chr7	73604636	+	GTF2I	chr7	74173109	+
98966	GBM	TCGA-06-2557-01A	EIF4H	chr7	73604636	+	GTF2I	chr7	74173110	+
90893	N/A	BM479877	EIF4H	chr7	73609960	+	H2AFY	chr5	134724788	-
65819	N/A	BU540394	EIF4H	chr7	73611005	+	PKP3	chr11	404687	+
78420	OV	TCGA-30-1718-01A	GTF2I	chr7	74131270	+	EIF4H	chr7	73604003	+
78424	N/A	CN419986	RSL1D1	chr16	11931662	-	EIF4H	chr7	73606366	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BRCA	EIF4H	0.00593130276779389	0.17
HNSC	EIF4H	0.00735663196199421	0.2

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	EIF4H	0.00208636558563239	0.069
HNSC	EIF4H	0.024791595665812	0.79

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source