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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: SLBP (NCBI Gene ID:7884)

Gene Summary

Gene Summary

Gene Information	Gene Name: SLBP
	Gene ID: 7884
	Gene Symbol	SLBP
	Gene ID	7884
	Gene Name	stem-loop binding protein
	Synonyms	HBP
	Cytomap	4p16.3
	Type of Gene	protein-coding
	Description	histone RNA hairpin-binding proteinhairpin binding protein, histonehistone binding proteinhistone stem-loop binding proteinstem-loop (histone) binding protein
	Modification date	20200313
	UniProtAcc	Q14493

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0002181	Cytoplasmic translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SLBP	GO:0051028	mRNA transport	19155325

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
SLBP	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'SLBP[title] AND translation [title] AND human.'

Gene	Title	PMID
SLBP	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000489418	1696500	1696567	Frame-shift
ENST00000489418	1697928	1698078	In-frame
ENST00000489418	1701737	1701797	In-frame
ENST00000489418	1705322	1705427	In-frame
ENST00000489418	1713600	1713717	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000489418	1697928	1698078	1994	847	996	270	160	209
ENST00000489418	1701737	1701797	1994	649	708	270	94	113
ENST00000489418	1705322	1705427	1994	544	648	270	59	93
ENST00000489418	1713600	1713717	1994	427	543	270	20	58

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q14493	94	113	1	270	Chain	ID=PRO_0000100356;Note=Histone RNA hairpin-binding protein
Q14493	160	209	1	270	Chain	ID=PRO_0000100356;Note=Histone RNA hairpin-binding protein
Q14493	59	93	1	270	Chain	ID=PRO_0000100356;Note=Histone RNA hairpin-binding protein
Q14493	20	58	1	270	Chain	ID=PRO_0000100356;Note=Histone RNA hairpin-binding protein
Q14493	160	209	129	198	Region	Note=RNA-binding
Q14493	20	58	31	34	Motif	Note=Nuclear localization signal NLS1
Q14493	94	113	96	99	Motif	Note=Nuclear localization signal NLS2
Q14493	20	58	20	20	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:23186163;Dbxref=PMID:17081983,PMID:23186163
Q14493	20	58	23	23	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:17081983,ECO:0000244\|PubMed:23186163;Dbxref=PMID:17081983,PMID:23186163
Q14493	59	93	59	59	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q14493	59	93	61	61	Modified residue	Note=Phosphothreonine%3B by CK2;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:12588979,ECO:0000269\|PubMed:18490441;Dbxref=PMID:12588979,PMID:18490441
Q14493	59	93	62	62	Modified residue	Note=Phosphothreonine%3B by CDK1;Ontology_term=ECO:0000244,ECO:0000269,ECO:0000269;evidence=ECO:0000244\|PubMed:23186163,ECO:0000269\|PubMed:12588979,ECO:0000269\|PubMed:18490441;Dbxref=PMID:23186163,PMID:12588979,PMID:18490441
Q14493	160	209	171	171	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244\|PubMed:23186163,ECO:0000269\|PubMed:22439849;Dbxref=PMID:23186163,PMID:22439849
Q14493	160	209	182	182	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:21406692;Dbxref=PMID:21406692
Q14493	94	113	98	98	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q14493	20	58	20	58	Alternative sequence	ID=VSP_042164;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q14493	20	58	31	34	Mutagenesis	Note=Reduces interaction with the importin alpha/importin beta receptor. Abolishes interaction with the importin alpha/importin beta receptor%3B when associated with A-96%3B A-97%3B A-98 and A-99 or with A-241%3B A-242%3B A-243 and A-244. RKRR->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:15829567;Dbxref=PMID:15829567
Q14493	59	93	59	63	Mutagenesis	Note=Does not increase its stability at the end of the S phase and through G2 and mitosis. SFTTP->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18490441;Dbxref=PMID:18490441
Q14493	59	93	59	59	Mutagenesis	Note=Does not increase its stability at the end of the S phase and through G2 and mitosis. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12588979;Dbxref=PMID:12588979
Q14493	59	93	61	61	Mutagenesis	Note=Increases its stability at the end of the S phase and through G2 and mitosis. Active in histone pre-mRNA processing during the G2 phase. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:12588979,ECO:0000269\|PubMed:18490441;Dbxref=PMID:12588979,PMID:18490441
Q14493	59	93	62	62	Mutagenesis	Note=Increases its stability at the end of the S phase and through G2 and mitosis. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:12588979,ECO:0000269\|PubMed:18490441;Dbxref=PMID:12588979,PMID:18490441
Q14493	59	93	63	63	Mutagenesis	Note=Increases its stability at the end of the S phase and through G2 and mitosis. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12588979;Dbxref=PMID:12588979
Q14493	94	113	96	99	Mutagenesis	Note=Increases its stability at the end of the S phase and through G2 and mitosis. Inhibits phosphorylation of T-62. Localizes in the nucleus. Reduces interaction with the importin alpha/importin beta receptor. Abolishes interaction with the importin alpha/importin beta receptor%3B when associated with A-31%3B A-32%3B A-33 and A-34 or with A-241%3B A-242%3B A-243 and A-244. KRKL->AAAA;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:12588979,ECO:0000269\|PubMed:15829567,ECO:0000269\|PubMed:18490441;Dbxref=PMID:12588979,PMID:15829567,PMID:18490441
Q14493	160	209	165	167	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4QOZ
Q14493	160	209	180	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4QOZ
Q14493	160	209	195	197	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4QOZ

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
CHOL	SLBP	-2.47916114694844	0.0078125
ESCA	SLBP	-1.20779658007017	0.0322265625
LIHC	SLBP	-1.92161263408532	1.82457528521744e-08
THCA	SLBP	-2.09860049531233	7.22868172738035e-09

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with SLBP (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
THYM	Cell metabolism gene	SLBP	POLE2	0.802042064	1.25E-28
THYM	Cell metabolism gene	SLBP	PAICS	0.802818729	1.01E-28
THYM	Cell metabolism gene	SLBP	HMMR	0.811235065	9.64E-30
THYM	Cell metabolism gene	SLBP	CCT5	0.81204516	7.65E-30
THYM	Cell metabolism gene	SLBP	HPRT1	0.812339931	7.02E-30
THYM	Cell metabolism gene	SLBP	IDH2	0.834564511	7.38E-33
THYM	Cell metabolism gene	SLBP	EXOSC3	0.865782257	6.97E-38
THYM	Cell metabolism gene	SLBP	PPP2CA	0.887309994	3.77E-42
THYM	CGC	SLBP	FANCD2	0.802720524	1.04E-28
THYM	CGC	SLBP	HNRNPA2B1	0.80486222	5.77E-29
THYM	CGC	SLBP	SET	0.807592104	2.70E-29
THYM	CGC	SLBP	RAP1GDS1	0.815865038	2.52E-30
THYM	CGC	SLBP	EZH2	0.817390774	1.61E-30
THYM	CGC	SLBP	BLM	0.821879536	4.16E-31
THYM	CGC	SLBP	SFPQ	0.826325347	1.05E-31
THYM	CGC	SLBP	IDH2	0.834564511	7.38E-33
THYM	Epifactor	SLBP	ANP32E	0.805374691	5.01E-29
THYM	Epifactor	SLBP	SET	0.807592104	2.70E-29
THYM	Epifactor	SLBP	CHAF1A	0.815222083	3.04E-30
THYM	Epifactor	SLBP	EZH2	0.817390774	1.61E-30
THYM	Epifactor	SLBP	HELLS	0.820709567	5.93E-31
THYM	Epifactor	SLBP	SFPQ	0.826325347	1.05E-31
THYM	Epifactor	SLBP	WHSC1	0.839117689	1.60E-33
THYM	Epifactor	SLBP	VRK1	0.840045105	1.16E-33
THYM	Epifactor	SLBP	CDK1	0.847065668	9.80E-35
THYM	Epifactor	SLBP	CBX3	0.850327224	2.98E-35
THYM	Epifactor	SLBP	AURKA	0.855833504	3.73E-36
THYM	Epifactor	SLBP	H2AFZ	0.860984677	4.94E-37
THYM	Epifactor	SLBP	UBE2T	0.863713432	1.64E-37
THYM	Epifactor	SLBP	EXOSC3	0.865782257	6.97E-38
THYM	Epifactor	SLBP	PCNA	0.869735219	1.31E-38
THYM	Epifactor	SLBP	H2AFY	0.881060068	7.93E-41
THYM	Epifactor	SLBP	PPP2CA	0.887309994	3.77E-42
THYM	IUPHAR	SLBP	KIF11	0.803296497	8.86E-29
THYM	IUPHAR	SLBP	MAP2K6	0.813139104	5.58E-30
THYM	IUPHAR	SLBP	EZH2	0.817390774	1.61E-30
THYM	IUPHAR	SLBP	NEK2	0.833714434	9.77E-33
THYM	IUPHAR	SLBP	IDH2	0.834564511	7.38E-33
THYM	IUPHAR	SLBP	VRK1	0.840045105	1.16E-33
THYM	IUPHAR	SLBP	MELK	0.842127093	5.65E-34
THYM	IUPHAR	SLBP	CDK1	0.847065668	9.80E-35
THYM	IUPHAR	SLBP	AURKA	0.855833504	3.73E-36
THYM	Kinase	SLBP	MAP2K6	0.813139104	5.58E-30
THYM	Kinase	SLBP	NEK2	0.833714434	9.77E-33
THYM	Kinase	SLBP	VRK1	0.840045105	1.16E-33
THYM	Kinase	SLBP	MELK	0.842127093	5.65E-34
THYM	Kinase	SLBP	CDK1	0.847065668	9.80E-35
THYM	Kinase	SLBP	AURKA	0.855833504	3.73E-36
THYM	TF	SLBP	ZNF367	0.817865068	1.39E-30
THYM	TF	SLBP	FOXM1	0.836121699	4.40E-33
THYM	TSG	SLBP	EZH2	0.817390774	1.61E-30
THYM	TSG	SLBP	BLM	0.821879536	4.16E-31
THYM	TSG	SLBP	PPP2CA	0.887309994	3.77E-42
UCS	Cell metabolism gene	SLBP	POLE2	0.802042064	1.25E-28
UCS	Cell metabolism gene	SLBP	PAICS	0.802818729	1.01E-28
UCS	Cell metabolism gene	SLBP	HMMR	0.811235065	9.64E-30
UCS	Cell metabolism gene	SLBP	CCT5	0.81204516	7.65E-30
UCS	Cell metabolism gene	SLBP	HPRT1	0.812339931	7.02E-30
UCS	Cell metabolism gene	SLBP	IDH2	0.834564511	7.38E-33
UCS	Cell metabolism gene	SLBP	EXOSC3	0.865782257	6.97E-38
UCS	Cell metabolism gene	SLBP	PPP2CA	0.887309994	3.77E-42
UCS	CGC	SLBP	FANCD2	0.802720524	1.04E-28
UCS	CGC	SLBP	HNRNPA2B1	0.80486222	5.77E-29
UCS	CGC	SLBP	SET	0.807592104	2.70E-29
UCS	CGC	SLBP	RAP1GDS1	0.815865038	2.52E-30
UCS	CGC	SLBP	EZH2	0.817390774	1.61E-30
UCS	CGC	SLBP	BLM	0.821879536	4.16E-31
UCS	CGC	SLBP	SFPQ	0.826325347	1.05E-31
UCS	CGC	SLBP	IDH2	0.834564511	7.38E-33
UCS	Epifactor	SLBP	ANP32E	0.805374691	5.01E-29
UCS	Epifactor	SLBP	SET	0.807592104	2.70E-29
UCS	Epifactor	SLBP	CHAF1A	0.815222083	3.04E-30
UCS	Epifactor	SLBP	EZH2	0.817390774	1.61E-30
UCS	Epifactor	SLBP	HELLS	0.820709567	5.93E-31
UCS	Epifactor	SLBP	SFPQ	0.826325347	1.05E-31
UCS	Epifactor	SLBP	WHSC1	0.839117689	1.60E-33
UCS	Epifactor	SLBP	VRK1	0.840045105	1.16E-33
UCS	Epifactor	SLBP	CDK1	0.847065668	9.80E-35
UCS	Epifactor	SLBP	CBX3	0.850327224	2.98E-35
UCS	Epifactor	SLBP	AURKA	0.855833504	3.73E-36
UCS	Epifactor	SLBP	H2AFZ	0.860984677	4.94E-37
UCS	Epifactor	SLBP	UBE2T	0.863713432	1.64E-37
UCS	Epifactor	SLBP	EXOSC3	0.865782257	6.97E-38
UCS	Epifactor	SLBP	PCNA	0.869735219	1.31E-38
UCS	Epifactor	SLBP	H2AFY	0.881060068	7.93E-41
UCS	Epifactor	SLBP	PPP2CA	0.887309994	3.77E-42
UCS	IUPHAR	SLBP	KIF11	0.803296497	8.86E-29
UCS	IUPHAR	SLBP	MAP2K6	0.813139104	5.58E-30
UCS	IUPHAR	SLBP	EZH2	0.817390774	1.61E-30
UCS	IUPHAR	SLBP	NEK2	0.833714434	9.77E-33
UCS	IUPHAR	SLBP	IDH2	0.834564511	7.38E-33
UCS	IUPHAR	SLBP	VRK1	0.840045105	1.16E-33
UCS	IUPHAR	SLBP	MELK	0.842127093	5.65E-34
UCS	IUPHAR	SLBP	CDK1	0.847065668	9.80E-35
UCS	IUPHAR	SLBP	AURKA	0.855833504	3.73E-36
UCS	Kinase	SLBP	MAP2K6	0.813139104	5.58E-30
UCS	Kinase	SLBP	NEK2	0.833714434	9.77E-33
UCS	Kinase	SLBP	VRK1	0.840045105	1.16E-33
UCS	Kinase	SLBP	MELK	0.842127093	5.65E-34
UCS	Kinase	SLBP	CDK1	0.847065668	9.80E-35
UCS	Kinase	SLBP	AURKA	0.855833504	3.73E-36
UCS	TF	SLBP	ZNF367	0.817865068	1.39E-30
UCS	TF	SLBP	FOXM1	0.836121699	4.40E-33
UCS	TSG	SLBP	EZH2	0.817390774	1.61E-30
UCS	TSG	SLBP	BLM	0.821879536	4.16E-31
UCS	TSG	SLBP	PPP2CA	0.887309994	3.77E-42
UVM	IUPHAR	SLBP	SLC30A9	0.828460521	2.48E-21

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	SLBP	UPF1	-1.33899089151335	0.000117696606626909
KICH	SLBP	LSM11	1.35861447682096	0.000187873840332031
HNSC	SLBP	LSM11	-1.3019291812046	0.000193349219898665
LUAD	SLBP	LSM11	-1.03300052934079	0.000391133065002894
KIRP	SLBP	LSM11	-3.46441899119354	0.000433447770774365
HNSC	SLBP	ZNF473	-2.72179036430173	0.000968624545066633
CHOL	SLBP	ERI1	-1.51778483624386	0.00390625
CHOL	SLBP	MIF4GD	-2.92474154465758	0.00390625
HNSC	SLBP	NUP50	1.26643314436008	0.0040605245990264
LIHC	SLBP	UPF1	-1.92491321082533	0.00427166918402987
LUSC	SLBP	LSM11	-1.58090767722563	0.00787511215605575
LUAD	SLBP	LSM10	-2.75173869609086	0.0111014174202378
PRAD	SLBP	ZNF473	-1.41531514231239	0.0278551491578459
LUAD	SLBP	NUP50	-7.82026307951008	1.30692790027182e-05
LIHC	SLBP	LSM11	-1.3611933352323	1.59591656448153e-05
LUAD	SLBP	NCBP1	-2.33130964948431	1.81586577755686e-08
PRAD	SLBP	LSM11	-1.85067026377478	2.44300720634817e-06
KIRC	SLBP	NCBP1	1.82316126239442	2.95519875508206e-07
KIRC	SLBP	ZNF473	-1.31496359739404	3.19639984652097e-08
PRAD	SLBP	UPF1	1.18312136515194	3.77428293642232e-05
LIHC	SLBP	ZNF473	-1.39655124691992	5.4415434348336e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with SLBP

ERI1, ZNF473, UPF1, CDK4, CDK6, GSTM3, HIST1H2BG, TACC3, FEM1A, FEM1B, FEM1C, CUL2, NCBP1, CTIF, CCNF, CCNA2, DCAF11, CUL4A, SKP1, CDK1, CDK2, EIF4G1, ZCCHC6, MIF4GD, CSNK2A1, CSNK2A2, CUL1, P4HA3, ZFC3H1, K8, DDB1, DHX15, SF3B1, CSTF3, CPSF3, MEPCE, LARP7, RC3H1, RC3H2, SNRNP70, PTGER4, SREBF2, GRHPR, TULP3, COIL, CIRH1A, FZR1, OTUB1, GATAD1, SRSF6, ACAD11, MTSS1L, GOLGA8G, NDOR1, LHPP, SPIN1, SPSB4, EP300,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
SLBP	KIRP	chr4	1701385	1701385	C	G	Missense_Mutation	p.E129Q	4
SLBP	CESC	chr4	1701317	1701317	G	A	Silent		3
SLBP	UCEC	chr4	1705398	1705398	C	T	Missense_Mutation	p.R69H	3
SLBP	UCS	chr4	1698041	1698041	T	G	Missense_Mutation	p.N173H	3
SLBP	SKCM	chr4	1695353	1695353	G	A	Missense_Mutation	p.P262S	2
SLBP	BRCA	chr4	1698071	1698071	G	A	Nonsense_Mutation	p.R163*	2
SLBP	STAD	chr4	1696506	1696506	C	T	Missense_Mutation	p.D231N	2
SLBP	LIHC	chr4	1701341	1701341	G	C	Missense_Mutation		2
SLBP	LIHC	chr4	1701341	1701341	G	C	Missense_Mutation	p.N143K	2
SLBP	UCEC	chr4	1698020	1698020	G	A	Nonsense_Mutation	p.R180*	2
SLBP	UCEC	chr4	1701798	1701798	C	A	Splice_Site	e4-1	2
SLBP	PRAD	chr4	1696566	1696566	G	A	Splice_Site	p.H211_splice	1
SLBP	BLCA	chr4	1701765	1701765	C	T	Missense_Mutation		1
SLBP	HNSC	chr4	1701409	1701409	T	C	Missense_Mutation	p.M121V	1
SLBP	BLCA	chr4	1701765	1701765	C	T	Missense_Mutation	p.G105E	1
SLBP	SKCM	chr4	1701427	1701427	A	G	Splice_Site	p.S115_splice	1
SLBP	KIRP	chr4	1701385	1701385	C	G	Missense_Mutation		1
SLBP	STAD	chr4	1696553	1696553	A	C	Missense_Mutation	p.L215R	1
SLBP	COAD	chr4	1697998	1697998	A	G	Missense_Mutation	p.I187T	1
SLBP	STAD	chr4	1701386	1701386	A	G	Silent	p.F128F	1
SLBP	COAD	chr4	1701316	1701316	C	T	Missense_Mutation	p.D152N	1
SLBP	LIHC	chr4	1701359	1701359	C	G	Missense_Mutation	p.R137S	1
SLBP	COAD	chr4	1696525	1696525	G	T	Silent	p.P224P	1
SLBP	LIHC	chr4	1696501	1696501	A	-	Splice_Site	p.F232_splice	1
SLBP	GBM	chr4	1701407	1701407	C	T	Missense_Mutation	p.M121I	1
SLBP	LIHC	chr4	1697969	1697969	A	-	Frame_Shift_Del	p.W197fs	1
SLBP	GBM	chr4	1701756	1701756	C	A	Missense_Mutation		1
SLBP	LIHC	chr4	1696549	1696549	T	-	Frame_Shift_Del	p.E216fs	1
SLBP	UCS	chr4	1698041	1698041	T	G	Missense_Mutation		1
SLBP	GBM	chr4	1701407	1701407	C	T	Missense_Mutation		1
SLBP	LUAD	chr4	1705370	1705370	T	A	Silent	p.A78A	1
SLBP	BLCA	chr4	1697997	1697997	G	T	Silent		1
SLBP	HNSC	chr4	1701409	1701409	T	C	Missense_Mutation		1

Copy number variation (CNV) of SLBP
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across SLBP
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
82185	N/A	BX091114	APOB	chr2	21261503	-	SLBP	chr4	1699311	-
82185	STAD	TCGA-VQ-A8PE	LETM1	chr4	1821064	-	SLBP	chr4	1705427	-
82185	STAD	TCGA-VQ-A8PE-01A	LETM1	chr4	1821065	-	SLBP	chr4	1705427	-
93131	BLCA	TCGA-CF-A47V	SLBP	chr4	1713600	-	ADD1	chr4	2896308	+
93131	BLCA	TCGA-CF-A47V-01A	SLBP	chr4	1713601	-	ADD1	chr4	2896309	+
99227	HNSC	TCGA-CR-7370	SLBP	chr4	1696500	-	LETM1	chr4	1827410	-
99227	HNSC	TCGA-CR-7370-01A	SLBP	chr4	1696501	-	LETM1	chr4	1827410	-
99227	LUSC	TCGA-LA-A7SW	SLBP	chr4	1713600	-	LETM1	chr4	1817529	-
99227	LUSC	TCGA-LA-A7SW-01A	SLBP	chr4	1713601	-	LETM1	chr4	1817529	-
82187	N/A	CD240302	SLBP	chr4	1694653	-	SLBP	chr4	1694786	+
101184	LUAD	TCGA-38-4630-01A	SLBP	chr4	1713601	-	TACC3	chr4	1732614	+
88675	OV	TCGA-10-0937-01A	SLBP	chr4	1713601	-	TMEM129	chr4	1720353	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	SLBP	0.00564178024157797	0.16
KIRP	SLBP	0.0124141732532376	0.34
KIRC	SLBP	0.0139218247871821	0.36
LUAD	SLBP	0.0167957503485337	0.42
LAML	SLBP	0.0273971909367601	0.66

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	SLBP	0.0171934366225425	0.52
LGG	SLBP	0.00740840703735938	0.23
PRAD	SLBP	0.044477336517274	1
UCEC	SLBP	0.00521576372366687	0.17
THYM	SLBP	0.000480378355728872	0.016

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0009363	Congenital ocular coloboma (disorder)	1	CTD_human
C0029124	Optic Atrophy	1	CTD_human
C0035313	Retinal Dysplasia	1	CTD_human
C4554007	Uveoretinal Coloboma	1	CTD_human