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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: FASTKD3 (NCBI Gene ID:79072)

Gene Summary

Gene Summary

Gene Information	Gene Name: FASTKD3
	Gene ID: 79072
	Gene Symbol	FASTKD3
	Gene ID	79072
	Gene Name	FAST kinase domains 3
	Synonyms	-
	Cytomap	5p15.31
	Type of Gene	protein-coding
	Description	FAST kinase domain-containing protein 3, mitochondrial
	Modification date	20200313
	UniProtAcc	Q14CZ7

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0032543	Mitochondrial translation
GO:0045727	Positive regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FASTKD3	GO:0033617	mitochondrial respiratory chain complex IV assembly	27789713
Hgene	FASTKD3	GO:0044528	regulation of mitochondrial mRNA stability	27789713
Hgene	FASTKD3	GO:0070131	positive regulation of mitochondrial translation	27789713

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
FASTKD3	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'FASTKD3[title] AND translation [title] AND human.'

Gene	Title	PMID
FASTKD3	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000264669	7861695	7861765	Frame-shift
ENST00000264669	7862935	7863110	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
HNSC	FASTKD3	-1.7319070300219	0.000115587435630005
BLCA	FASTKD3	-3.02557784649012	0.000209808349609375
STAD	FASTKD3	-4.16152598839565	0.00315681146457791

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
LIHC	FASTKD3	1	2	0.0465634762901828	0.156116388888889	0.24080796460177	0.671140616466399	0.83310477575905

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
GBM	FASTKD3	0.216264899	0.037822838

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with FASTKD3 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
THYM	Cell metabolism gene	FASTKD3	UPRT	0.809130012	1.75E-29
THYM	CGC	FASTKD3	RAD17	0.846344343	1.27E-34
THYM	IUPHAR	FASTKD3	MAPK9	0.821642225	4.47E-31
THYM	Kinase	FASTKD3	MAPK9	0.821642225	4.47E-31
THYM	TSG	FASTKD3	INTS6	0.801611493	1.40E-28
THYM	TSG	FASTKD3	MAPK9	0.821642225	4.47E-31
UCS	Cell metabolism gene	FASTKD3	UPRT	0.809130012	1.75E-29
UCS	CGC	FASTKD3	RAD17	0.846344343	1.27E-34
UCS	IUPHAR	FASTKD3	MAPK9	0.821642225	4.47E-31
UCS	Kinase	FASTKD3	MAPK9	0.821642225	4.47E-31
UCS	TSG	FASTKD3	INTS6	0.801611493	1.40E-28
UCS	TSG	FASTKD3	MAPK9	0.821642225	4.47E-31
UVM	Cell metabolism gene	FASTKD3	PPP1CB	0.800315938	5.25E-19
UVM	Cell metabolism gene	FASTKD3	ENOPH1	0.80048	5.10E-19
UVM	Cell metabolism gene	FASTKD3	NUPL1	0.801105235	4.57E-19
UVM	Cell metabolism gene	FASTKD3	SPCS3	0.802180545	3.78E-19
UVM	Cell metabolism gene	FASTKD3	L2HGDH	0.80338562	3.06E-19
UVM	Cell metabolism gene	FASTKD3	MINPP1	0.803724909	2.88E-19
UVM	Cell metabolism gene	FASTKD3	IMPA1	0.805072687	2.26E-19
UVM	Cell metabolism gene	FASTKD3	PANK3	0.805249984	2.19E-19
UVM	Cell metabolism gene	FASTKD3	PIK3C2A	0.805828286	1.97E-19
UVM	Cell metabolism gene	FASTKD3	PIKFYVE	0.806617294	1.71E-19
UVM	Cell metabolism gene	FASTKD3	GXYLT1	0.806724815	1.68E-19
UVM	Cell metabolism gene	FASTKD3	VBP1	0.806960701	1.61E-19
UVM	Cell metabolism gene	FASTKD3	RANBP2	0.807923322	1.35E-19
UVM	Cell metabolism gene	FASTKD3	NANP	0.808422481	1.23E-19
UVM	Cell metabolism gene	FASTKD3	HMGCR	0.809837462	9.49E-20
UVM	Cell metabolism gene	FASTKD3	DCP2	0.811614079	6.82E-20
UVM	Cell metabolism gene	FASTKD3	GPD2	0.811869546	6.50E-20
UVM	Cell metabolism gene	FASTKD3	TGS1	0.812997222	5.26E-20
UVM	Cell metabolism gene	FASTKD3	CSGALNACT2	0.816048587	2.95E-20
UVM	Cell metabolism gene	FASTKD3	CLOCK	0.816066809	2.94E-20
UVM	Cell metabolism gene	FASTKD3	ARFGEF2	0.816314118	2.80E-20
UVM	Cell metabolism gene	FASTKD3	RAP1B	0.816594802	2.65E-20
UVM	Cell metabolism gene	FASTKD3	HMGCS1	0.816891039	2.51E-20
UVM	Cell metabolism gene	FASTKD3	LCLAT1	0.818233058	1.93E-20
UVM	Cell metabolism gene	FASTKD3	GALNT11	0.819033746	1.65E-20
UVM	Cell metabolism gene	FASTKD3	POLR2B	0.81947971	1.52E-20
UVM	Cell metabolism gene	FASTKD3	MANEA	0.820417822	1.26E-20
UVM	Cell metabolism gene	FASTKD3	COL4A3BP	0.821325824	1.05E-20
UVM	Cell metabolism gene	FASTKD3	CCT2	0.82650388	3.72E-21
UVM	Cell metabolism gene	FASTKD3	MCEE	0.826618312	3.63E-21
UVM	Cell metabolism gene	FASTKD3	GPAM	0.827991066	2.74E-21
UVM	Cell metabolism gene	FASTKD3	PHAX	0.828575697	2.43E-21
UVM	Cell metabolism gene	FASTKD3	PPAT	0.829058393	2.19E-21
UVM	Cell metabolism gene	FASTKD3	AGPS	0.830249967	1.71E-21
UVM	Cell metabolism gene	FASTKD3	AASDHPPT	0.830392045	1.66E-21
UVM	Cell metabolism gene	FASTKD3	ACSL4	0.832517439	1.06E-21
UVM	Cell metabolism gene	FASTKD3	LYPLA1	0.834482338	6.96E-22
UVM	Cell metabolism gene	FASTKD3	MED4	0.834794551	6.51E-22
UVM	Cell metabolism gene	FASTKD3	DDX20	0.836122189	4.88E-22
UVM	Cell metabolism gene	FASTKD3	GNPDA2	0.837484106	3.62E-22
UVM	Cell metabolism gene	FASTKD3	BPNT1	0.840687092	1.78E-22
UVM	Cell metabolism gene	FASTKD3	PSMA4	0.844895016	6.81E-23
UVM	Cell metabolism gene	FASTKD3	FBXL3	0.849255487	2.44E-23
UVM	Cell metabolism gene	FASTKD3	FPGT	0.850635063	1.75E-23
UVM	Cell metabolism gene	FASTKD3	NUDT12	0.850745208	1.71E-23
UVM	Cell metabolism gene	FASTKD3	DCK	0.851909722	1.29E-23
UVM	Cell metabolism gene	FASTKD3	MED17	0.852089467	1.23E-23
UVM	Cell metabolism gene	FASTKD3	SRP19	0.854023476	7.67E-24
UVM	Cell metabolism gene	FASTKD3	CNOT8	0.854469621	6.86E-24
UVM	Cell metabolism gene	FASTKD3	DIS3	0.854895574	6.17E-24
UVM	Cell metabolism gene	FASTKD3	PNPLA8	0.856098396	4.57E-24
UVM	Cell metabolism gene	FASTKD3	ALG10B	0.857621928	3.11E-24
UVM	Cell metabolism gene	FASTKD3	IDI1	0.860272677	1.58E-24
UVM	Cell metabolism gene	FASTKD3	DBT	0.860407514	1.52E-24
UVM	Cell metabolism gene	FASTKD3	UGGT2	0.865924794	3.52E-25
UVM	Cell metabolism gene	FASTKD3	NAMPT	0.86600587	3.44E-25
UVM	Cell metabolism gene	FASTKD3	NUP107	0.866338384	3.15E-25
UVM	Cell metabolism gene	FASTKD3	SACM1L	0.867208394	2.48E-25
UVM	Cell metabolism gene	FASTKD3	PSMD14	0.869618604	1.27E-25
UVM	Cell metabolism gene	FASTKD3	MTMR6	0.870781619	9.19E-26
UVM	Cell metabolism gene	FASTKD3	FAR1	0.876635174	1.69E-26
UVM	Cell metabolism gene	FASTKD3	PLA2G12A	0.877292584	1.39E-26
UVM	Cell metabolism gene	FASTKD3	EDEM3	0.878521983	9.63E-27
UVM	Cell metabolism gene	FASTKD3	NUPL2	0.880061034	6.03E-27
UVM	Cell metabolism gene	FASTKD3	MED7	0.880211446	5.76E-27
UVM	Cell metabolism gene	FASTKD3	GRPEL2	0.880516235	5.25E-27
UVM	Cell metabolism gene	FASTKD3	NUP50	0.880779223	4.84E-27
UVM	Cell metabolism gene	FASTKD3	PRKAA1	0.885873151	9.74E-28
UVM	Cell metabolism gene	FASTKD3	TNPO1	0.886400925	8.22E-28
UVM	Cell metabolism gene	FASTKD3	PSMC6	0.890401119	2.20E-28
UVM	Cell metabolism gene	FASTKD3	XPO1	0.893543608	7.51E-29
UVM	Cell metabolism gene	FASTKD3	ETNK1	0.899853512	7.83E-30
UVM	CGC	FASTKD3	HSP90AA1	0.802503885	3.57E-19
UVM	CGC	FASTKD3	SMARCE1	0.807317181	1.51E-19
UVM	CGC	FASTKD3	MLLT10	0.807787592	1.38E-19
UVM	CGC	FASTKD3	RANBP2	0.807923322	1.35E-19
UVM	CGC	FASTKD3	CASP3	0.80892011	1.12E-19
UVM	CGC	FASTKD3	AKAP9	0.813743355	4.57E-20
UVM	CGC	FASTKD3	KTN1	0.819765619	1.43E-20
UVM	CGC	FASTKD3	SMAD4	0.819922159	1.39E-20
UVM	CGC	FASTKD3	TET2	0.820196324	1.32E-20
UVM	CGC	FASTKD3	TOP1	0.820339348	1.28E-20
UVM	CGC	FASTKD3	ARID2	0.823911589	6.29E-21
UVM	CGC	FASTKD3	DICER1	0.825169902	4.88E-21
UVM	CGC	FASTKD3	ITGAV	0.825263609	4.79E-21
UVM	CGC	FASTKD3	ERCC4	0.826837361	3.47E-21
UVM	CGC	FASTKD3	MSH2	0.828472149	2.48E-21
UVM	CGC	FASTKD3	RAD21	0.828695715	2.37E-21
UVM	CGC	FASTKD3	EZH2	0.829213111	2.13E-21
UVM	CGC	FASTKD3	CUL3	0.832642892	1.03E-21
UVM	CGC	FASTKD3	USP8	0.835553755	5.52E-22
UVM	CGC	FASTKD3	TRIM33	0.83618827	4.81E-22
UVM	CGC	FASTKD3	SS18L1	0.83939027	2.38E-22
UVM	CGC	FASTKD3	NBN	0.843500097	9.38E-23
UVM	CGC	FASTKD3	GOLGA5	0.845679107	5.67E-23
UVM	CGC	FASTKD3	ZMYM2	0.846242016	4.98E-23
UVM	CGC	FASTKD3	ABI1	0.852778262	1.04E-23
UVM	CGC	FASTKD3	POT1	0.855281902	5.61E-24
UVM	CGC	FASTKD3	KRAS	0.855434171	5.40E-24
UVM	CGC	FASTKD3	JAK2	0.855776241	4.96E-24
UVM	CGC	FASTKD3	DDX5	0.858979167	2.20E-24
UVM	CGC	FASTKD3	ATM	0.859855901	1.76E-24
UVM	CGC	FASTKD3	STAG2	0.862954563	7.80E-25
UVM	CGC	FASTKD3	BMPR1A	0.863357754	7.01E-25
UVM	CGC	FASTKD3	KIF5B	0.86352917	6.70E-25
UVM	CGC	FASTKD3	FBXO11	0.867080801	2.57E-25
UVM	CGC	FASTKD3	CDC73	0.8672106	2.48E-25
UVM	CGC	FASTKD3	RABEP1	0.873376987	4.39E-26
UVM	CGC	FASTKD3	PWWP2A	0.873520824	4.21E-26
UVM	CGC	FASTKD3	BAZ1A	0.875414649	2.42E-26
UVM	CGC	FASTKD3	SF3B1	0.883140134	2.32E-27
UVM	CGC	FASTKD3	XPO1	0.893543608	7.51E-29
UVM	CGC	FASTKD3	RAD17	0.896246003	2.90E-29
UVM	CGC	FASTKD3	ETNK1	0.899853512	7.83E-30
UVM	CGC	FASTKD3	CREB1	0.900087317	7.18E-30
UVM	CGC	FASTKD3	SUZ12	0.900433498	6.32E-30
UVM	CGC	FASTKD3	PMS1	0.905336836	9.69E-31
UVM	Epifactor	FASTKD3	PARG	0.803852048	2.81E-19
UVM	Epifactor	FASTKD3	PHIP	0.806006185	1.91E-19
UVM	Epifactor	FASTKD3	SMARCE1	0.807317181	1.51E-19
UVM	Epifactor	FASTKD3	TADA1	0.80758944	1.43E-19
UVM	Epifactor	FASTKD3	MLLT10	0.807787592	1.38E-19
UVM	Epifactor	FASTKD3	VRK1	0.808929376	1.12E-19
UVM	Epifactor	FASTKD3	ZRANB3	0.814235483	4.17E-20
UVM	Epifactor	FASTKD3	UHRF2	0.814390374	4.04E-20
UVM	Epifactor	FASTKD3	EID1	0.814812847	3.73E-20
UVM	Epifactor	FASTKD3	CLOCK	0.816066809	2.94E-20
UVM	Epifactor	FASTKD3	TAF9	0.816367032	2.77E-20
UVM	Epifactor	FASTKD3	MBTD1	0.817028623	2.44E-20
UVM	Epifactor	FASTKD3	CIR1	0.819316032	1.57E-20
UVM	Epifactor	FASTKD3	TET2	0.820196324	1.32E-20
UVM	Epifactor	FASTKD3	ARID2	0.823911589	6.29E-21
UVM	Epifactor	FASTKD3	CHUK	0.828323699	2.56E-21
UVM	Epifactor	FASTKD3	EZH2	0.829213111	2.13E-21
UVM	Epifactor	FASTKD3	HCFC2	0.829423923	2.03E-21
UVM	Epifactor	FASTKD3	BRMS1L	0.829626738	1.95E-21
UVM	Epifactor	FASTKD3	TAF2	0.829659614	1.94E-21
UVM	Epifactor	FASTKD3	SIRT1	0.831161671	1.41E-21
UVM	Epifactor	FASTKD3	CTBP2	0.832277595	1.12E-21
UVM	Epifactor	FASTKD3	CUL3	0.832642892	1.03E-21
UVM	Epifactor	FASTKD3	YY1	0.83321661	9.13E-22
UVM	Epifactor	FASTKD3	ANP32E	0.833718948	8.20E-22
UVM	Epifactor	FASTKD3	SMARCA5	0.834234176	7.34E-22
UVM	Epifactor	FASTKD3	TRIM33	0.83618827	4.81E-22
UVM	Epifactor	FASTKD3	RCOR3	0.836632216	4.37E-22
UVM	Epifactor	FASTKD3	RMI1	0.838067984	3.18E-22
UVM	Epifactor	FASTKD3	MTF2	0.838081308	3.18E-22
UVM	Epifactor	FASTKD3	CHD9	0.838583542	2.84E-22
UVM	Epifactor	FASTKD3	BRCC3	0.838846706	2.68E-22
UVM	Epifactor	FASTKD3	ARID4B	0.838994302	2.59E-22
UVM	Epifactor	FASTKD3	SS18L1	0.83939027	2.38E-22
UVM	Epifactor	FASTKD3	NIPBL	0.839917491	2.11E-22
UVM	Epifactor	FASTKD3	FAM175B	0.840122466	2.02E-22
UVM	Epifactor	FASTKD3	NBN	0.843500097	9.38E-23
UVM	Epifactor	FASTKD3	RAD54B	0.843756567	8.85E-23
UVM	Epifactor	FASTKD3	HAT1	0.845394349	6.06E-23
UVM	Epifactor	FASTKD3	CDK17	0.846217856	5.00E-23
UVM	Epifactor	FASTKD3	ZMYM2	0.846242016	4.98E-23
UVM	Epifactor	FASTKD3	CUL5	0.846579268	4.60E-23
UVM	Epifactor	FASTKD3	EPC2	0.847172494	4.00E-23
UVM	Epifactor	FASTKD3	TLK1	0.848183744	3.15E-23
UVM	Epifactor	FASTKD3	UCHL5	0.84862591	2.84E-23
UVM	Epifactor	FASTKD3	OGT	0.851336688	1.48E-23
UVM	Epifactor	FASTKD3	ARID4A	0.854981877	6.04E-24
UVM	Epifactor	FASTKD3	BAZ2B	0.855005765	6.01E-24
UVM	Epifactor	FASTKD3	JAK2	0.855776241	4.96E-24
UVM	Epifactor	FASTKD3	TDG	0.858377701	2.57E-24
UVM	Epifactor	FASTKD3	TAF7	0.85856119	2.45E-24
UVM	Epifactor	FASTKD3	ATM	0.859855901	1.76E-24
UVM	Epifactor	FASTKD3	YEATS4	0.861026033	1.30E-24
UVM	Epifactor	FASTKD3	PCGF6	0.863586497	6.60E-25
UVM	Epifactor	FASTKD3	ACTR6	0.865468781	3.98E-25
UVM	Epifactor	FASTKD3	CDC73	0.8672106	2.48E-25
UVM	Epifactor	FASTKD3	JMJD1C	0.868240472	1.87E-25
UVM	Epifactor	FASTKD3	CHD1	0.869078084	1.48E-25
UVM	Epifactor	FASTKD3	SMARCAD1	0.869402776	1.35E-25
UVM	Epifactor	FASTKD3	DNTTIP2	0.869654456	1.26E-25
UVM	Epifactor	FASTKD3	NSL1	0.873173794	4.65E-26
UVM	Epifactor	FASTKD3	CBX3	0.873768174	3.92E-26
UVM	Epifactor	FASTKD3	BRWD1	0.874654046	3.03E-26
UVM	Epifactor	FASTKD3	BAZ1A	0.875414649	2.42E-26
UVM	Epifactor	FASTKD3	RLIM	0.875908582	2.10E-26
UVM	Epifactor	FASTKD3	PHF20L1	0.878662332	9.23E-27
UVM	Epifactor	FASTKD3	HMGB1	0.87957765	6.99E-27
UVM	Epifactor	FASTKD3	ATAD2B	0.879765248	6.60E-27
UVM	Epifactor	FASTKD3	INO80D	0.880886079	4.68E-27
UVM	Epifactor	FASTKD3	MASTL	0.882638145	2.72E-27
UVM	Epifactor	FASTKD3	SF3B1	0.883140134	2.32E-27
UVM	Epifactor	FASTKD3	PRKAA1	0.885873151	9.74E-28
UVM	Epifactor	FASTKD3	AEBP2	0.888429888	4.23E-28
UVM	Epifactor	FASTKD3	SMEK1	0.889690921	2.79E-28
UVM	Epifactor	FASTKD3	CUL2	0.893479087	7.68E-29
UVM	Epifactor	FASTKD3	SMEK2	0.895824038	3.37E-29
UVM	Epifactor	FASTKD3	USP15	0.897809534	1.66E-29
UVM	Epifactor	FASTKD3	SUZ12	0.900433498	6.32E-30
UVM	IUPHAR	FASTKD3	STK3	0.801933163	3.95E-19
UVM	IUPHAR	FASTKD3	HSP90AA1	0.802503885	3.57E-19
UVM	IUPHAR	FASTKD3	ABCD3	0.803405904	3.04E-19
UVM	IUPHAR	FASTKD3	DYRK1A	0.803686316	2.90E-19
UVM	IUPHAR	FASTKD3	TMEM165	0.80388938	2.79E-19
UVM	IUPHAR	FASTKD3	IMPA1	0.805072687	2.26E-19
UVM	IUPHAR	FASTKD3	ATP2B1	0.805105074	2.25E-19
UVM	IUPHAR	FASTKD3	PIK3C2A	0.805828286	1.97E-19
UVM	IUPHAR	FASTKD3	PHIP	0.806006185	1.91E-19
UVM	IUPHAR	FASTKD3	PIKFYVE	0.806617294	1.71E-19
UVM	IUPHAR	FASTKD3	NEK1	0.808581087	1.20E-19
UVM	IUPHAR	FASTKD3	CASP3	0.80892011	1.12E-19
UVM	IUPHAR	FASTKD3	VRK1	0.808929376	1.12E-19
UVM	IUPHAR	FASTKD3	ADAM17	0.809757799	9.63E-20
UVM	IUPHAR	FASTKD3	HMGCR	0.809837462	9.49E-20
UVM	IUPHAR	FASTKD3	MAGT1	0.810342792	8.64E-20
UVM	IUPHAR	FASTKD3	SLC37A3	0.812309263	5.99E-20
UVM	IUPHAR	FASTKD3	SLC30A7	0.812900466	5.36E-20
UVM	IUPHAR	FASTKD3	ATP6V1C1	0.81363393	4.67E-20
UVM	IUPHAR	FASTKD3	CLK1	0.814528746	3.94E-20
UVM	IUPHAR	FASTKD3	PDIK1L	0.814733863	3.79E-20
UVM	IUPHAR	FASTKD3	CLOCK	0.816066809	2.94E-20
UVM	IUPHAR	FASTKD3	RPS6KC1	0.816370172	2.77E-20
UVM	IUPHAR	FASTKD3	HMGCS1	0.816891039	2.51E-20
UVM	IUPHAR	FASTKD3	ATP6V0A2	0.818466029	1.85E-20
UVM	IUPHAR	FASTKD3	PRPF4B	0.819644802	1.47E-20
UVM	IUPHAR	FASTKD3	TOP1	0.820339348	1.28E-20
UVM	IUPHAR	FASTKD3	SLC38A2	0.822496022	8.35E-21
UVM	IUPHAR	FASTKD3	CLK4	0.82323589	7.21E-21
UVM	IUPHAR	FASTKD3	ITGAV	0.825263609	4.79E-21
UVM	IUPHAR	FASTKD3	BMPR2	0.828201041	2.62E-21
UVM	IUPHAR	FASTKD3	CHUK	0.828323699	2.56E-21
UVM	IUPHAR	FASTKD3	PPAT	0.829058393	2.19E-21
UVM	IUPHAR	FASTKD3	EZH2	0.829213111	2.13E-21
UVM	IUPHAR	FASTKD3	MAP3K2	0.830619758	1.58E-21
UVM	IUPHAR	FASTKD3	SIRT1	0.831161671	1.41E-21
UVM	IUPHAR	FASTKD3	TRIM33	0.83618827	4.81E-22
UVM	IUPHAR	FASTKD3	MARK3	0.83685955	4.15E-22
UVM	IUPHAR	FASTKD3	NEK7	0.838119565	3.15E-22
UVM	IUPHAR	FASTKD3	STK38L	0.838682037	2.78E-22
UVM	IUPHAR	FASTKD3	RIOK2	0.844304378	7.80E-23
UVM	IUPHAR	FASTKD3	HAT1	0.845394349	6.06E-23
UVM	IUPHAR	FASTKD3	CDK17	0.846217856	5.00E-23
UVM	IUPHAR	FASTKD3	BIRC2	0.846516509	4.67E-23
UVM	IUPHAR	FASTKD3	TLK1	0.848183744	3.15E-23
UVM	IUPHAR	FASTKD3	SLC30A5	0.848856564	2.69E-23
UVM	IUPHAR	FASTKD3	USP14	0.851299334	1.49E-23
UVM	IUPHAR	FASTKD3	VRK2	0.851632964	1.38E-23
UVM	IUPHAR	FASTKD3	NR2C1	0.85309344	9.64E-24
UVM	IUPHAR	FASTKD3	CSNK1A1	0.854781953	6.35E-24
UVM	IUPHAR	FASTKD3	BAZ2B	0.855005765	6.01E-24
UVM	IUPHAR	FASTKD3	KRAS	0.855434171	5.40E-24
UVM	IUPHAR	FASTKD3	JAK2	0.855776241	4.96E-24
UVM	IUPHAR	FASTKD3	STK17A	0.856062271	4.61E-24
UVM	IUPHAR	FASTKD3	SLC25A46	0.857201143	3.46E-24
UVM	IUPHAR	FASTKD3	TNKS2	0.857832611	2.95E-24
UVM	IUPHAR	FASTKD3	IRAK4	0.859847338	1.76E-24
UVM	IUPHAR	FASTKD3	ATM	0.859855901	1.76E-24
UVM	IUPHAR	FASTKD3	IDI1	0.860272677	1.58E-24
UVM	IUPHAR	FASTKD3	PKN2	0.861322261	1.20E-24
UVM	IUPHAR	FASTKD3	BMPR1A	0.863357754	7.01E-25
UVM	IUPHAR	FASTKD3	FBXO11	0.867080801	2.57E-25
UVM	IUPHAR	FASTKD3	TRPM7	0.867720756	2.16E-25
UVM	IUPHAR	FASTKD3	JMJD1C	0.868240472	1.87E-25
UVM	IUPHAR	FASTKD3	PSMD14	0.869618604	1.27E-25
UVM	IUPHAR	FASTKD3	RIOK3	0.869803877	1.21E-25
UVM	IUPHAR	FASTKD3	ABCB10	0.870592688	9.70E-26
UVM	IUPHAR	FASTKD3	CSNK1G3	0.872758927	5.24E-26
UVM	IUPHAR	FASTKD3	XIAP	0.873430473	4.32E-26
UVM	IUPHAR	FASTKD3	BRWD1	0.874654046	3.03E-26
UVM	IUPHAR	FASTKD3	BAZ1A	0.875414649	2.42E-26
UVM	IUPHAR	FASTKD3	PLA2G12A	0.877292584	1.39E-26
UVM	IUPHAR	FASTKD3	ATAD2B	0.879765248	6.60E-27
UVM	IUPHAR	FASTKD3	MASTL	0.882638145	2.72E-27
UVM	IUPHAR	FASTKD3	PRMT3	0.883726004	1.93E-27
UVM	IUPHAR	FASTKD3	PRKAA1	0.885873151	9.74E-28
UVM	IUPHAR	FASTKD3	MAPK6	0.891280695	1.63E-28
UVM	IUPHAR	FASTKD3	XPO1	0.893543608	7.51E-29
UVM	IUPHAR	FASTKD3	TBK1	0.895126502	4.32E-29
UVM	IUPHAR	FASTKD3	NAPEPLD	0.903185231	2.23E-30
UVM	IUPHAR	FASTKD3	MAP4K3	0.917497141	5.75E-33
UVM	Kinase	FASTKD3	PAN3	0.800164364	5.39E-19
UVM	Kinase	FASTKD3	STK3	0.801933163	3.95E-19
UVM	Kinase	FASTKD3	DYRK1A	0.803686316	2.90E-19
UVM	Kinase	FASTKD3	NEK1	0.808581087	1.20E-19
UVM	Kinase	FASTKD3	VRK1	0.808929376	1.12E-19
UVM	Kinase	FASTKD3	CLK1	0.814528746	3.94E-20
UVM	Kinase	FASTKD3	PDIK1L	0.814733863	3.79E-20
UVM	Kinase	FASTKD3	RPS6KC1	0.816370172	2.77E-20
UVM	Kinase	FASTKD3	PRPF4B	0.819644802	1.47E-20
UVM	Kinase	FASTKD3	COL4A3BP	0.821325824	1.05E-20
UVM	Kinase	FASTKD3	CLK4	0.82323589	7.21E-21
UVM	Kinase	FASTKD3	BMPR2	0.828201041	2.62E-21
UVM	Kinase	FASTKD3	CHUK	0.828323699	2.56E-21
UVM	Kinase	FASTKD3	MAP3K2	0.830619758	1.58E-21
UVM	Kinase	FASTKD3	TRIM33	0.83618827	4.81E-22
UVM	Kinase	FASTKD3	MARK3	0.83685955	4.15E-22
UVM	Kinase	FASTKD3	NEK7	0.838119565	3.15E-22
UVM	Kinase	FASTKD3	STK38L	0.838682037	2.78E-22
UVM	Kinase	FASTKD3	RIOK2	0.844304378	7.80E-23
UVM	Kinase	FASTKD3	CDK17	0.846217856	5.00E-23
UVM	Kinase	FASTKD3	TLK1	0.848183744	3.15E-23
UVM	Kinase	FASTKD3	VRK2	0.851632964	1.38E-23
UVM	Kinase	FASTKD3	CSNK1A1	0.854781953	6.35E-24
UVM	Kinase	FASTKD3	JAK2	0.855776241	4.96E-24
UVM	Kinase	FASTKD3	STK17A	0.856062271	4.61E-24
UVM	Kinase	FASTKD3	IRAK4	0.859847338	1.76E-24
UVM	Kinase	FASTKD3	ATM	0.859855901	1.76E-24
UVM	Kinase	FASTKD3	PKN2	0.861322261	1.20E-24
UVM	Kinase	FASTKD3	BMPR1A	0.863357754	7.01E-25
UVM	Kinase	FASTKD3	TRPM7	0.867720756	2.16E-25
UVM	Kinase	FASTKD3	RIOK3	0.869803877	1.21E-25
UVM	Kinase	FASTKD3	CSNK1G3	0.872758927	5.24E-26
UVM	Kinase	FASTKD3	BAZ1A	0.875414649	2.42E-26
UVM	Kinase	FASTKD3	MASTL	0.882638145	2.72E-27
UVM	Kinase	FASTKD3	PRKAA1	0.885873151	9.74E-28
UVM	Kinase	FASTKD3	MAPK6	0.891280695	1.63E-28
UVM	Kinase	FASTKD3	TBK1	0.895126502	4.32E-29
UVM	Kinase	FASTKD3	MAP4K3	0.917497141	5.75E-33
UVM	TF	FASTKD3	ZNF235	0.800027186	5.52E-19
UVM	TF	FASTKD3	ZNF585B	0.802085252	3.85E-19
UVM	TF	FASTKD3	ZNF808	0.803425493	3.03E-19
UVM	TF	FASTKD3	TERF1	0.803598388	2.94E-19
UVM	TF	FASTKD3	ZNF266	0.806050015	1.90E-19
UVM	TF	FASTKD3	ZNF37A	0.806180919	1.85E-19
UVM	TF	FASTKD3	ZNF644	0.80645746	1.76E-19
UVM	TF	FASTKD3	ZKSCAN5	0.806497934	1.75E-19
UVM	TF	FASTKD3	ZNF606	0.807148962	1.55E-19
UVM	TF	FASTKD3	ZNF420	0.807170222	1.55E-19
UVM	TF	FASTKD3	ZFP14	0.807684537	1.41E-19
UVM	TF	FASTKD3	NFXL1	0.807869328	1.36E-19
UVM	TF	FASTKD3	ZNF45	0.808549108	1.20E-19
UVM	TF	FASTKD3	ZNF20	0.808690787	1.17E-19
UVM	TF	FASTKD3	SP4	0.809179345	1.07E-19
UVM	TF	FASTKD3	ZNF17	0.809543924	1.00E-19
UVM	TF	FASTKD3	ZNF443	0.810246446	8.80E-20
UVM	TF	FASTKD3	ZNF223	0.810805446	7.93E-20
UVM	TF	FASTKD3	ZNF253	0.811297988	7.23E-20
UVM	TF	FASTKD3	TMF1	0.811326928	7.20E-20
UVM	TF	FASTKD3	ZNF470	0.812470361	5.81E-20
UVM	TF	FASTKD3	ZNF569	0.815138509	3.51E-20
UVM	TF	FASTKD3	ZNF461	0.815237549	3.44E-20
UVM	TF	FASTKD3	ZNF248	0.815763135	3.11E-20
UVM	TF	FASTKD3	ZBED5	0.816045414	2.95E-20
UVM	TF	FASTKD3	CLOCK	0.816066809	2.94E-20
UVM	TF	FASTKD3	ZNF141	0.816082085	2.93E-20
UVM	TF	FASTKD3	ZNF791	0.816578433	2.66E-20
UVM	TF	FASTKD3	ZNF83	0.81661897	2.64E-20
UVM	TF	FASTKD3	ELF1	0.816879744	2.51E-20
UVM	TF	FASTKD3	ZNF484	0.817234404	2.35E-20
UVM	TF	FASTKD3	ZNF280C	0.818304723	1.91E-20
UVM	TF	FASTKD3	ZNF614	0.819025373	1.66E-20
UVM	TF	FASTKD3	SMAD4	0.819922159	1.39E-20
UVM	TF	FASTKD3	TET2	0.820196324	1.32E-20
UVM	TF	FASTKD3	ZNF440	0.820242599	1.31E-20
UVM	TF	FASTKD3	ZNF674	0.820356061	1.28E-20
UVM	TF	FASTKD3	ZNF799	0.821819112	9.56E-21
UVM	TF	FASTKD3	ZNF780B	0.822536605	8.29E-21
UVM	TF	FASTKD3	ZNF624	0.823227715	7.22E-21
UVM	TF	FASTKD3	RLF	0.823586999	6.72E-21
UVM	TF	FASTKD3	ARID2	0.823911589	6.29E-21
UVM	TF	FASTKD3	ZNF148	0.824804962	5.25E-21
UVM	TF	FASTKD3	ZNF320	0.825321372	4.73E-21
UVM	TF	FASTKD3	ZNF557	0.826085816	4.05E-21
UVM	TF	FASTKD3	ZNF354B	0.827608632	2.96E-21
UVM	TF	FASTKD3	PRDM10	0.828051395	2.70E-21
UVM	TF	FASTKD3	ZNF555	0.828279254	2.58E-21
UVM	TF	FASTKD3	ELF2	0.831032452	1.45E-21
UVM	TF	FASTKD3	ZNF230	0.831076656	1.44E-21
UVM	TF	FASTKD3	BACH1	0.831808725	1.23E-21
UVM	TF	FASTKD3	CEBPG	0.832496821	1.06E-21
UVM	TF	FASTKD3	YY1	0.83321661	9.13E-22
UVM	TF	FASTKD3	ZNF658	0.834419853	7.06E-22
UVM	TF	FASTKD3	ZNF44	0.8366628	4.34E-22
UVM	TF	FASTKD3	MTF2	0.838081308	3.18E-22
UVM	TF	FASTKD3	ZNF225	0.838082573	3.17E-22
UVM	TF	FASTKD3	ZNF200	0.838090354	3.17E-22
UVM	TF	FASTKD3	ZNF224	0.838553551	2.86E-22
UVM	TF	FASTKD3	MEF2A	0.838848242	2.68E-22
UVM	TF	FASTKD3	ZNF143	0.840381046	1.90E-22
UVM	TF	FASTKD3	ZNF75D	0.840391078	1.90E-22
UVM	TF	FASTKD3	ZNF146	0.840655256	1.79E-22
UVM	TF	FASTKD3	ZNF480	0.841402193	1.51E-22
UVM	TF	FASTKD3	MYNN	0.844060653	8.25E-23
UVM	TF	FASTKD3	AHCTF1	0.844850194	6.88E-23
UVM	TF	FASTKD3	ZNF566	0.845032763	6.59E-23
UVM	TF	FASTKD3	ZNF761	0.846276581	4.94E-23
UVM	TF	FASTKD3	ZNF567	0.846312968	4.89E-23
UVM	TF	FASTKD3	ZNF14	0.846713484	4.46E-23
UVM	TF	FASTKD3	ZNF564	0.846916156	4.25E-23
UVM	TF	FASTKD3	ZNF25	0.847243487	3.93E-23
UVM	TF	FASTKD3	PURB	0.848595051	2.86E-23
UVM	TF	FASTKD3	TOPORS	0.848899727	2.66E-23
UVM	TF	FASTKD3	ZNF268	0.849128025	2.52E-23
UVM	TF	FASTKD3	ZNF101	0.849682233	2.20E-23
UVM	TF	FASTKD3	ZNF546	0.850040818	2.02E-23
UVM	TF	FASTKD3	ZNF721	0.850113389	1.99E-23
UVM	TF	FASTKD3	ZNF430	0.850497749	1.81E-23
UVM	TF	FASTKD3	LIN54	0.852901185	1.01E-23
UVM	TF	FASTKD3	NR2C1	0.85309344	9.64E-24
UVM	TF	FASTKD3	ZNF10	0.853876561	7.95E-24
UVM	TF	FASTKD3	BAZ2B	0.855005765	6.01E-24
UVM	TF	FASTKD3	CREBZF	0.855340676	5.53E-24
UVM	TF	FASTKD3	ZNF84	0.855700765	5.05E-24
UVM	TF	FASTKD3	ZNF326	0.856361126	4.28E-24
UVM	TF	FASTKD3	ZNF468	0.856726013	3.90E-24
UVM	TF	FASTKD3	ZNF700	0.856978655	3.66E-24
UVM	TF	FASTKD3	ZNF33A	0.858889889	2.25E-24
UVM	TF	FASTKD3	ZBTB41	0.859098213	2.13E-24
UVM	TF	FASTKD3	ZNF845	0.859249678	2.05E-24
UVM	TF	FASTKD3	ZNF302	0.859744132	1.81E-24
UVM	TF	FASTKD3	ZNF383	0.859887309	1.74E-24
UVM	TF	FASTKD3	ZNF449	0.860941342	1.32E-24
UVM	TF	FASTKD3	SP3	0.861590537	1.12E-24
UVM	TF	FASTKD3	THAP6	0.861893432	1.03E-24
UVM	TF	FASTKD3	ZNF432	0.86235417	9.14E-25
UVM	TF	FASTKD3	ZNF100	0.862770646	8.19E-25
UVM	TF	FASTKD3	ZNF280D	0.862838572	8.05E-25
UVM	TF	FASTKD3	PCGF6	0.863586497	6.60E-25
UVM	TF	FASTKD3	THAP9	0.865128565	4.37E-25
UVM	TF	FASTKD3	RBAK	0.866885219	2.71E-25
UVM	TF	FASTKD3	ZNF527	0.867321027	2.41E-25
UVM	TF	FASTKD3	ZNF222	0.867367063	2.38E-25
UVM	TF	FASTKD3	ZNF26	0.867641784	2.20E-25
UVM	TF	FASTKD3	ZNF800	0.869026877	1.50E-25
UVM	TF	FASTKD3	ZNF195	0.869198542	1.43E-25
UVM	TF	FASTKD3	ZNF510	0.871328372	7.88E-26
UVM	TF	FASTKD3	ZNF131	0.871403262	7.71E-26
UVM	TF	FASTKD3	ZNF138	0.871684994	7.12E-26
UVM	TF	FASTKD3	GABPA	0.873164211	4.66E-26
UVM	TF	FASTKD3	ZNF234	0.873222093	4.59E-26
UVM	TF	FASTKD3	ZNF701	0.873508913	4.22E-26
UVM	TF	FASTKD3	ZNF254	0.875254021	2.54E-26
UVM	TF	FASTKD3	ZNF708	0.875256818	2.54E-26
UVM	TF	FASTKD3	ZNF12	0.875430892	2.41E-26
UVM	TF	FASTKD3	ZNF180	0.875698558	2.23E-26
UVM	TF	FASTKD3	DMTF1	0.876099433	1.98E-26
UVM	TF	FASTKD3	IKZF5	0.876214174	1.92E-26
UVM	TF	FASTKD3	CEBPZ	0.877399649	1.35E-26
UVM	TF	FASTKD3	ZBTB6	0.878005814	1.12E-26
UVM	TF	FASTKD3	GPBP1	0.878402911	9.98E-27
UVM	TF	FASTKD3	ZNF518A	0.878960274	8.43E-27
UVM	TF	FASTKD3	ZNF431	0.879186889	7.87E-27
UVM	TF	FASTKD3	ZNF441	0.880045885	6.06E-27
UVM	TF	FASTKD3	ZNF451	0.880785186	4.83E-27
UVM	TF	FASTKD3	ZNF260	0.881813692	3.52E-27
UVM	TF	FASTKD3	ZNF675	0.881857519	3.47E-27
UVM	TF	FASTKD3	PRMT3	0.883726004	1.93E-27
UVM	TF	FASTKD3	ZNF24	0.884842085	1.36E-27
UVM	TF	FASTKD3	FOXN2	0.885175139	1.22E-27
UVM	TF	FASTKD3	ZNF28	0.886458749	8.07E-28
UVM	TF	FASTKD3	ZNF226	0.887394495	5.95E-28
UVM	TF	FASTKD3	AEBP2	0.888429888	4.23E-28
UVM	TF	FASTKD3	ZNF680	0.890408886	2.19E-28
UVM	TF	FASTKD3	ZNF136	0.891183467	1.69E-28
UVM	TF	FASTKD3	ZNF181	0.891677414	1.43E-28
UVM	TF	FASTKD3	SMAD5	0.892419116	1.11E-28
UVM	TF	FASTKD3	ZNF267	0.893217428	8.40E-29
UVM	TF	FASTKD3	ZNF43	0.893846027	6.76E-29
UVM	TF	FASTKD3	ZNF780A	0.89418796	6.00E-29
UVM	TF	FASTKD3	ZNF182	0.894535378	5.31E-29
UVM	TF	FASTKD3	ZNF92	0.895227599	4.17E-29
UVM	TF	FASTKD3	CREB1	0.900087317	7.18E-30
UVM	TF	FASTKD3	THAP5	0.901845636	3.72E-30
UVM	TF	FASTKD3	ZNF140	0.90710459	4.81E-31
UVM	TF	FASTKD3	ZBTB1	0.915869322	1.19E-32
UVM	TSG	FASTKD3	COPS2	0.801321258	4.40E-19
UVM	TSG	FASTKD3	NEDD4	0.805496836	2.09E-19
UVM	TSG	FASTKD3	PTPN2	0.810831543	7.89E-20
UVM	TSG	FASTKD3	ANXA7	0.812051074	6.29E-20
UVM	TSG	FASTKD3	UHRF2	0.814390374	4.04E-20
UVM	TSG	FASTKD3	CCAR1	0.819420924	1.53E-20
UVM	TSG	FASTKD3	SMAD4	0.819922159	1.39E-20
UVM	TSG	FASTKD3	TET2	0.820196324	1.32E-20
UVM	TSG	FASTKD3	ARID2	0.823911589	6.29E-21
UVM	TSG	FASTKD3	DICER1	0.825169902	4.88E-21
UVM	TSG	FASTKD3	ITGAV	0.825263609	4.79E-21
UVM	TSG	FASTKD3	BMPR2	0.828201041	2.62E-21
UVM	TSG	FASTKD3	CHUK	0.828323699	2.56E-21
UVM	TSG	FASTKD3	MSH2	0.828472149	2.48E-21
UVM	TSG	FASTKD3	RB1CC1	0.829080058	2.19E-21
UVM	TSG	FASTKD3	EZH2	0.829213111	2.13E-21
UVM	TSG	FASTKD3	SIRT1	0.831161671	1.41E-21
UVM	TSG	FASTKD3	IFT88	0.831604924	1.29E-21
UVM	TSG	FASTKD3	RBBP8	0.834454452	7.00E-22
UVM	TSG	FASTKD3	USP33	0.8360457	4.96E-22
UVM	TSG	FASTKD3	PDS5B	0.837091065	3.95E-22
UVM	TSG	FASTKD3	DCLRE1A	0.837634563	3.50E-22
UVM	TSG	FASTKD3	GGNBP2	0.838338737	3.00E-22
UVM	TSG	FASTKD3	VEZT	0.839526519	2.30E-22
UVM	TSG	FASTKD3	NBN	0.843500097	9.38E-23
UVM	TSG	FASTKD3	TANK	0.844046486	8.28E-23
UVM	TSG	FASTKD3	CUL5	0.846579268	4.60E-23
UVM	TSG	FASTKD3	FAM188A	0.84702891	4.14E-23
UVM	TSG	FASTKD3	TOPORS	0.848899727	2.66E-23
UVM	TSG	FASTKD3	WDR11	0.853118991	9.58E-24
UVM	TSG	FASTKD3	CSNK1A1	0.854781953	6.35E-24
UVM	TSG	FASTKD3	PPM1A	0.85502855	5.97E-24
UVM	TSG	FASTKD3	APAF1	0.858450241	2.52E-24
UVM	TSG	FASTKD3	ATM	0.859855901	1.76E-24
UVM	TSG	FASTKD3	BMPR1A	0.863357754	7.01E-25
UVM	TSG	FASTKD3	MLH3	0.864334668	5.40E-25
UVM	TSG	FASTKD3	LIN9	0.864609949	5.02E-25
UVM	TSG	FASTKD3	CDC73	0.8672106	2.48E-25
UVM	TSG	FASTKD3	INTS6	0.867549412	2.26E-25
UVM	TSG	FASTKD3	KRIT1	0.868969932	1.53E-25
UVM	TSG	FASTKD3	CHD1	0.869078084	1.48E-25
UVM	TSG	FASTKD3	DMTF1	0.876099433	1.98E-26
UVM	TSG	FASTKD3	PRKAA1	0.885873151	9.74E-28
UVM	TSG	FASTKD3	SMCHD1	0.88753031	5.69E-28
UVM	TSG	FASTKD3	GORAB	0.890427774	2.18E-28
UVM	TSG	FASTKD3	CUL2	0.893479087	7.68E-29
UVM	TSG	FASTKD3	SUZ12	0.900433498	6.32E-30
UVM	TSG	FASTKD3	NAPEPLD	0.903185231	2.23E-30
UVM	TSG	FASTKD3	RINT1	0.906835484	5.36E-31

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	FASTKD3	DHX30	-1.81225880349461	0.000125885009765625
HNSC	FASTKD3	ETFA	-2.24746914413963	0.000145686987025329
COAD	FASTKD3	ETFA	-1.12848178795374	0.000166177749633789
LIHC	FASTKD3	MRPS31	-1.07565232256163	0.000180054839259286
KICH	FASTKD3	PNPT1	1.84455116577408	0.000187873840332031
KIRP	FASTKD3	MCCC2	-1.75888222033834	0.000306400004774332
KICH	FASTKD3	PTCD1	-6.090490574251	0.000382499321847452
LUAD	FASTKD3	MRPS31	1.58140915700442	0.00351308111790755
CHOL	FASTKD3	ETFA	-2.30365475269335	0.00390625
CHOL	FASTKD3	MCCC2	-2.71231342349791	0.00390625
LIHC	FASTKD3	PNPT1	-1.04502631808729	0.00967934859969721
STAD	FASTKD3	DHX30	-4.92522543625672	0.0099095250479877
HNSC	FASTKD3	DHX30	1.32454643538405	0.011197180198451
HNSC	FASTKD3	MCCC2	1.35982492832798	0.0116138248772586
KICH	FASTKD3	MRPS31	-1.44171613577495	0.0173123478889465
BRCA	FASTKD3	MTO1	-1.09257288004134	0.0200878768110553
PRAD	FASTKD3	ETFA	-2.25834673752175	0.0241985658238267
COAD	FASTKD3	MRPS31	1.25930610083678	0.0253507494926453
PRAD	FASTKD3	PTCD1	1.30597206825589	0.0298556903933808
READ	FASTKD3	DHX30	-3.18371228020359	0.03125
READ	FASTKD3	ETFA	-2.37515146459453	0.03125
STAD	FASTKD3	IARS2	-1.36774073274524	0.0324882394634187
BLCA	FASTKD3	MRPS31	-1.74989716581638	0.0445594787597656
KICH	FASTKD3	MRPS22	1.59345779884986	0.0451226830482483
STAD	FASTKD3	PNPT1	-2.72869865637622	1.11940316855908e-05
PRAD	FASTKD3	ALDH18A1	-1.7813662332682	1.26099370313262e-05
KIRP	FASTKD3	ETFA	-2.8966780209214	1.26352533698082e-05
PRAD	FASTKD3	MCCC2	1.25260522976322	2.30901551406799e-08
KIRC	FASTKD3	ALDH18A1	-2.31220376170135	2.33261111911382e-06
KIRC	FASTKD3	MTO1	-1.03081816734249	2.47012955490964e-07
KIRP	FASTKD3	MTO1	-3.77202252731403	2.49594449996948e-07
BRCA	FASTKD3	IARS2	1.50870900515201	2.53632294696759e-14
BRCA	FASTKD3	MCCC2	1.34469071918541	2.86302424906618e-09
KIRC	FASTKD3	DHX30	1.95683537699729	2.87398106288596e-12
KIRC	FASTKD3	PNPT1	1.16005507166092	2.90348670181982e-08
KIRC	FASTKD3	ETFA	-2.69520465543	3.74686018928209e-07
LUAD	FASTKD3	PTCD1	-2.59962414376334	4.36641792271383e-10
LUAD	FASTKD3	MCCC2	-2.15449261787785	4.58785409961826e-10
PRAD	FASTKD3	MTO1	-2.87181302059323	4.59461327401057e-05
LUAD	FASTKD3	ETFA	-2.05490169196678	4.97091356683099e-05
KIRC	FASTKD3	MCCC2	-4.07386937502847	6.13427141633893e-11
PRAD	FASTKD3	MRPS31	1.42878008978338	6.76861513404814e-05
THCA	FASTKD3	MRPS31	-1.55759809933211	6.91106419786075e-09
THCA	FASTKD3	ALDH18A1	-2.42869627661137	7.2135636200392e-06
KIRC	FASTKD3	MRPS31	-4.32541004240865	9.31897250092369e-08

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with FASTKD3

VHL, MAGEA12, AGTRAP, FAM9B, BSG, SPACA1, KIR2DS2, PLAUR, SIAE, LAMP3, VTN, MUC20, SLAMF1, NPY2R, AGK, ABHD10, ACOT1, ACOT2, AFG3L2, ATPAF1, C17orf80, DAP3, DBT, DHX30, DLST, ELAC2, ERAL1, ETFA, ETFB, FLG2, GRSF1, HNRNPA3, HNRNPAB, HNRNPDL, HSPD1, IARS2, KIAA0391, KRT5, KRT6A, KRT77, LARS2, LETM1, LRPPRC, MMAB, MRPL12, MRPL15, MRPL21, MRPL24, MRPL28, MRPL37, MRPL4, MRPL41, MRPL42, MRPL43, MRPL44, MRPL45, MRPL47, MRPL49, MRPL50, MRPL53, MRPL9, MRPS10, MRPS11, MRPS14, MRPS16, MRPS17, MRPS18B, MRPS18C, MRPS2, MRPS22, MRPS23, MRPS24, MRPS25, MRPS26, MRPS27, MRPS28, MRPS31, MRPS33, MRPS34, MRPS35, MRPS36, MRPS5, MRPS6, MRPS7, MRPS9, MTIF2, NDUFA12, NDUFA2, NDUFA5, NDUFA6, NDUFA7, NDUFA9, NDUFAF4, NDUFS1, NDUFS2, NDUFS3, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NME4, OGDH, OXA1L, PDHA1, PNPT1, PPIF, PTCD3, PYCR1, PYCR2, RBMX, SHMT2, SLIRP, TACO1, TIMM44, TRMT10C, VARS2, M, CS, TNFSF13, CD80, TMEM9, P2RY10, MAGEA8, GPR182, CXCR4, KLRC1, HCST, OSTM1, GYPA, CLEC2D, IL12RB1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
FASTKD3	COAD	chr5	7867769	7867769	T	-	Frame_Shift_Del	p.K143fs	11
FASTKD3	PAAD	chr5	7868079	7868079	G	A	Missense_Mutation	p.R40C	5
FASTKD3	BLCA	chr5	7867809	7867809	C	T	Missense_Mutation	p.A130T	4
FASTKD3	KIRP	chr5	7867621	7867621	A	G	Silent	p.P192P	4
FASTKD3	BLCA	chr5	7861273	7861273	G	C	Missense_Mutation	p.Q625E	4
FASTKD3	KIRP	chr5	7867451	7867451	T	C	Missense_Mutation	p.E249G	4
FASTKD3	BRCA	chr5	7867557	7867557	C	A	Nonsense_Mutation	p.E214*	4
FASTKD3	UCEC	chr5	7861280	7861280	G	A	Silent	p.L622	4
FASTKD3	BRCA	chr5	7867647	7867647	C	T	Missense_Mutation	p.A184T	4
FASTKD3	BRCA	chr5	7867856	7867856	T	A	Missense_Mutation	p.E114V	4
FASTKD3	LIHC	chr5	7868117	7868117	T	-	Frame_Shift_Del	p.N27fs	4
FASTKD3	UCEC	chr5	7867808	7867808	G	A	Missense_Mutation	p.A130V	3
FASTKD3	UCS	chr5	7863053	7863053	G	C	Missense_Mutation	p.L528V	3
FASTKD3	PAAD	chr5	7867281	7867281	G	T	Missense_Mutation	p.L306I	3
FASTKD3	PAAD	chr5	7866895	7866895	G	A	Silent	p.N434N	3
FASTKD3	UVM	chr5	7859575	7859575	T	C	Silent	p.Q654Q	3
FASTKD3	PAAD	chr5	7861322	7861322	T	C	Silent	p.L608L	3
FASTKD3	BLCA	chr5	7861273	7861273	G	C	Missense_Mutation		3
FASTKD3	READ	chr5	7867115	7867115	G	A	Missense_Mutation	p.A361V	3
FASTKD3	HNSC	chr5	7867642	7867642	C	G	Silent	p.L185L	2
FASTKD3	LUAD	chr5	7866983	7866983	G	C	Missense_Mutation	p.P405R	2
FASTKD3	ESCA	chr5	7867768	7867768	C	T	Silent		2
FASTKD3	ESCA	chr5	7867768	7867768	C	T	Silent	p.K143K	2
FASTKD3	STAD	chr5	7863113	7863113	A	-	Splice_Site	p.G509_splice	2
FASTKD3	BLCA	chr5	7867383	7867383	C	T	Missense_Mutation		2
FASTKD3	LIHC	chr5	7867391	7867391	T	A	Missense_Mutation	p.K269I	2
FASTKD3	LUAD	chr5	7868043	7868043	G	A	Missense_Mutation	p.P52S	2
FASTKD3	UVM	chr5	7859575	7859575	T	C	Silent		2
FASTKD3	ESCA	chr5	7867883	7867883	C	A	Missense_Mutation	p.R105I	2
FASTKD3	SARC	chr5	7859616	7859616	G	A	Missense_Mutation		2
FASTKD3	COAD	chr5	7867231	7867231	G	A	Silent	p.V322V	2
FASTKD3	HNSC	chr5	7868022	7868022	G	C	Missense_Mutation	p.H59D	2
FASTKD3	LUAD	chr5	7866830	7866830	G	A	Missense_Mutation	p.S456L	2
FASTKD3	STAD	chr5	7867738	7867738	T	C	Missense_Mutation	p.I153M	2
FASTKD3	SARC	chr5	7868054	7868054	C	T	Missense_Mutation		2
FASTKD3	LIHC	chr5	7867919	7867919	T	-	Frame_Shift_Del	p.N93fs	2
FASTKD3	LUAD	chr5	7863072	7863072	A	T	Missense_Mutation	p.F521L	2
FASTKD3	UCEC	chr5	7866989	7866989	A	C	Missense_Mutation	p.F403C	2
FASTKD3	COAD	chr5	7867768	7867769	-	T	Frame_Shift_Ins	p.K143fs	2
FASTKD3	LIHC	chr5	7866952	7866952	A	-	Frame_Shift_Del	p.F415fs	2
FASTKD3	STAD	chr5	7867447	7867447	T	C	Silent	p.T250T	2
FASTKD3	BLCA	chr5	7867383	7867383	C	T	Missense_Mutation	p.E272K	2
FASTKD3	HNSC	chr5	7859654	7859654	T	C	Splice_Site		2
FASTKD3	UCEC	chr5	7867081	7867081	G	A	Silent	p.C372	2
FASTKD3	LIHC	chr5	7868050	7868050	T	-	Frame_Shift_Del	p.Q49fs	2
FASTKD3	STAD	chr5	7866882	7866882	G	T	Missense_Mutation	p.H439N	2
FASTKD3	CESC	chr5	7867109	7867109	C	T	Missense_Mutation		2
FASTKD3	KIRP	chr5	7867451	7867451	T	C	Missense_Mutation		2
FASTKD3	THCA	chr5	7868025	7868025	G	A	Missense_Mutation	p.H58Y	2
FASTKD3	UCEC	chr5	7867438	7867438	C	T	Silent	p.P253	2
FASTKD3	HNSC	chr5	7867502	7867502	C	T	Missense_Mutation	p.G232D	2
FASTKD3	STAD	chr5	7861317	7861317	C	T	Missense_Mutation	p.G610E	2
FASTKD3	CESC	chr5	7867647	7867647	C	T	Missense_Mutation		2
FASTKD3	PAAD	chr5	7861322	7861322	T	C	Silent		2
FASTKD3	SKCM	chr5	7868072	7868072	C	T	Missense_Mutation	p.C42Y	2
FASTKD3	UCEC	chr5	7867578	7867578	G	A	Missense_Mutation	p.R207C	2
FASTKD3	DLBC	chr5	7867027	7867027	A	G	Silent	p.N390N	2
FASTKD3	HNSC	chr5	7867445	7867445	A	T	Missense_Mutation	p.F251Y	2
FASTKD3	STAD	chr5	7867527	7867527	T	-	Frame_Shift_Del	p.S224fs	2
FASTKD3	BLCA	chr5	7861360	7861360	C	G	Missense_Mutation	p.D596H	2
FASTKD3	CESC	chr5	7866836	7866836	G	A	Missense_Mutation		2
FASTKD3	LAML	chr5	7920321	7920321	A	G	Silent	p.S292	2
FASTKD3	PAAD	chr5	7866895	7866895	G	A	Silent		2
FASTKD3	SKCM	chr5	7866981	7866981	G	A	Missense_Mutation	p.R406C	2
FASTKD3	UCEC	chr5	7867849	7867849	T	C	Silent	p.L116	2
FASTKD3	HNSC	chr5	7867698	7867698	C	G	Missense_Mutation	p.E167Q	2
FASTKD3	HNSC	chr5	7861342	7861342	A	G	Missense_Mutation	p.C602R	2
FASTKD3	BLCA	chr5	7867567	7867567	T	C	Silent	p.K210K	2
FASTKD3	PAAD	chr5	7867281	7867281	G	T	Missense_Mutation		2
FASTKD3	HNSC	chr5	7867461	7867461	C	T	Missense_Mutation	p.E246K	2
FASTKD3	LUAD	chr5	7866922	7866922	G	T	Silent	p.A425A	2
FASTKD3	SKCM	chr5	7867292	7867292	G	A	Missense_Mutation	p.A302V	2
FASTKD3	UCEC	chr5	7867936	7867936	G	A	Silent	p.C87	2
FASTKD3	ESCA	chr5	7867439	7867439	G	T	Missense_Mutation	p.P253Q	2
FASTKD3	BLCA	chr5	7867275	7867275	G	C	Missense_Mutation	p.Q308E	2
FASTKD3	SKCM	chr5	7868163	7868163	G	A	Missense_Mutation	p.R12C	1
FASTKD3	UCS	chr5	7863053	7863053	G	C	Missense_Mutation		1
FASTKD3	OV	chr5	7920785	7920785	A	C	Missense_Mutation		1
FASTKD3	STAD	chr5	7867338	7867338	T	C	Missense_Mutation	p.I287V	1
FASTKD3	BLCA	chr5	7866072	7866072	A	C	Missense_Mutation	p.L488W	1
FASTKD3	HNSC	chr5	7867502	7867502	C	T	Missense_Mutation		1
FASTKD3	SARC	chr5	7861717	7861717	G	T	Missense_Mutation		1
FASTKD3	BLCA	chr5	7867190	7867190	C	G	Missense_Mutation		1
FASTKD3	COAD	chr5	7863064	7863064	G	T	Missense_Mutation	p.P524Q	1
FASTKD3	LIHC	chr5	7867406	7867406	T	C	Missense_Mutation	p.Q264R	1
FASTKD3	HNSC	chr5	7868154	7868154	C	T	Missense_Mutation	p.D15N	1
FASTKD3	LUAD	chr5	7867304	7867304	T	G	Missense_Mutation	p.Q298P	1
FASTKD3	SKCM	chr5	7859613	7859613	C	A	Nonsense_Mutation	p.E642*	1
FASTKD3	KIRP	chr5	7867537	7867537	A	G	Silent	p.I220I	1
FASTKD3	OV	chr5	7920144	7920144	A	G	Silent	p.F351	1
FASTKD3	BLCA	chr5	7867306	7867306	G	C	Missense_Mutation	p.S297R	1
FASTKD3	HNSC	chr5	7868022	7868022	G	C	Missense_Mutation		1
FASTKD3	SARC	chr5	7867128	7867128	G	T	Missense_Mutation		1
FASTKD3	UCEC	chr5	7861280	7861280	G	A	Silent	p.L622L	1
FASTKD3	COAD	chr5	7867038	7867039	-	T	Frame_Shift_Ins	p.P387fs	1
FASTKD3	HNSC	chr5	7867058	7867058	C	G	Missense_Mutation	p.R380T	1
FASTKD3	STAD	chr5	7866771	7866771	G	A	Nonsense_Mutation	p.Q476X	1
FASTKD3	BLCA	chr5	7867692	7867692	C	G	Missense_Mutation	p.E169Q	1
FASTKD3	KIRP	chr5	7867443	7867443	T	C	Missense_Mutation	p.T252A	1
FASTKD3	OV	chr5	7920620	7920623	GAGG	-	Frame_Shift_Del	p.P192fs	1
FASTKD3	STAD	chr5	7861316	7861316	C	G	Silent		1
FASTKD3	BLCA	chr5	7863022	7863022	C	T	Missense_Mutation	p.R538K	1
FASTKD3	HNSC	chr5	7863000	7863000	A	G	Silent		1
FASTKD3	UCEC	chr5	7867081	7867081	G	A	Silent	p.C372C	1
FASTKD3	BLCA	chr5	7861360	7861360	C	G	Missense_Mutation		1
FASTKD3	HNSC	chr5	7861342	7861342	A	G	Missense_Mutation		1
FASTKD3	LIHC	chr5	7868134	7868134	A	G	Silent	p.A21A	1
FASTKD3	BLCA	chr5	7866085	7866085	G	A	Missense_Mutation	p.H484Y	1
FASTKD3	ESCA	chr5	7867480	7867480	A	G	Silent	p.I239I	1
FASTKD3	OV	chr5	7919095	7919095	A	T	Silent	p.G480	1
FASTKD3	STAD	chr5	7866771	7866771	G	A	Nonsense_Mutation		1
FASTKD3	BLCA	chr5	7867567	7867567	T	C	Silent		1
FASTKD3	COAD	chr5	7867625	7867625	T	A	Missense_Mutation	p.D191V	1
FASTKD3	HNSC	chr5	7868154	7868154	C	T	Missense_Mutation		1
FASTKD3	HNSC	chr5	7867655	7867655	G	A	Missense_Mutation	p.A181V	1
FASTKD3	STAD	chr5	7863113	7863113	A	-	Splice_Site	.	1
FASTKD3	BLCA	chr5	7867190	7867190	C	G	Missense_Mutation	p.R336T	1
FASTKD3	HNSC	chr5	7867445	7867445	A	T	Missense_Mutation		1
FASTKD3	KIRP	chr5	7867846	7867846	A	G	Silent	p.S117S	1
FASTKD3	OV	chr5	7920012	7920012	A	C	Silent	p.T395	1
FASTKD3	THCA	chr5	7868030	7868030	T	C	Missense_Mutation		1
FASTKD3	SARC	chr5	7868054	7868054	C	T	Missense_Mutation	p.R48Q	1
FASTKD3	BLCA	chr5	7867275	7867275	G	C	Missense_Mutation		1
FASTKD3	HNSC	chr5	7867655	7867655	G	A	Missense_Mutation		1
FASTKD3	HNSC	chr5	7866918	7866918	C	A	Missense_Mutation	p.A427S	1
FASTKD3	LUAD	chr5	7867505	7867505	G	A	Missense_Mutation	p.S231L	1
FASTKD3	KIRP	chr5	7867846	7867846	A	G	Silent		1
FASTKD3	OV	chr5	7867093	7867093	A	G	Silent	p.P368	1
FASTKD3	PAAD	chr5	7867410	7867410	A	C	Missense_Mutation	p.L263V	1
FASTKD3	THCA	chr5	7868025	7868025	G	A	Missense_Mutation		1
FASTKD3	BLCA	chr5	7867809	7867809	C	T	Missense_Mutation		1
FASTKD3	SARC	chr5	7859616	7859616	G	A	Missense_Mutation	p.R641C	1
FASTKD3	BLCA	chr5	7867578	7867578	G	T	Missense_Mutation		1
FASTKD3	HNSC	chr5	7867058	7867058	C	G	Missense_Mutation		1
FASTKD3	HNSC	chr5	7866996	7866996	C	G	Missense_Mutation	p.E401Q	1
FASTKD3	LUAD	chr5	7868116	7868117	-	T	Frame_Shift_Ins	p.K27fs	1
FASTKD3	BLCA	chr5	7867071	7867071	C	G	Missense_Mutation	p.E376Q	1
FASTKD3	HNSC	chr5	7866918	7866918	C	A	Missense_Mutation		1
FASTKD3	PAAD	chr5	7866821	7866821	T	C	Missense_Mutation		1
FASTKD3	READ	chr5	7867047	7867047	G	T	Missense_Mutation	p.L384I	1
FASTKD3	SARC	chr5	7867128	7867128	G	T	Missense_Mutation	p.H357N	1
FASTKD3	BLCA	chr5	7866072	7866072	A	C	Missense_Mutation		1
FASTKD3	COAD	chr5	7867769	7867770	TT	-	Frame_Shift_Del	p.143_143del	1
FASTKD3	HNSC	chr5	7862969	7862969	G	C	Missense_Mutation		1
FASTKD3	LUSC	chr5	7867909	7867909	A	C	Missense_Mutation	p.N96K	1
FASTKD3	BLCA	chr5	7866908	7866908	C	G	Missense_Mutation	p.R430T	1
FASTKD3	HNSC	chr5	7866996	7866996	C	G	Missense_Mutation		1
FASTKD3	BLCA	chr5	7867692	7867692	C	G	Missense_Mutation		1
FASTKD3	KIRP	chr5	7867621	7867621	A	G	Silent		1
FASTKD3	THYM	chr5	7867769	7867769	T	-	Frame_Shift_Del		1
FASTKD3	BLCA	chr5	7867306	7867306	G	C	Missense_Mutation		1
FASTKD3	HNSC	chr5	7862969	7862969	G	C	Missense_Mutation	p.P556A	1
FASTKD3	LIHC	chr5	7861301	7861301	T	-	Frame_Shift_Del	p.K615fs	1
FASTKD3	LUSC	chr5	7868063	7868063	A	G	Missense_Mutation	p.L45S	1
FASTKD3	HNSC	chr5	7867461	7867461	C	T	Missense_Mutation		1
FASTKD3	BLCA	chr5	7866085	7866085	G	A	Missense_Mutation		1
FASTKD3	READ	chr5	7867551	7867551	G	A	Missense_Mutation	p.R216C	1
FASTKD3	THYM	chr5	7867105	7867105	G	T	Silent		1
FASTKD3	BLCA	chr5	7863022	7863022	C	T	Missense_Mutation		1
FASTKD3	ESCA	chr5	7867768	7867768	C	T	Silent	p.K143	1
FASTKD3	LIHC	chr5	7867391	7867391	T	A	Missense_Mutation		1
FASTKD3	LUSC	chr5	7867395	7867395	C	T	Missense_Mutation	p.E268K	1
FASTKD3	STAD	chr5	7866771	7866771	G	A	Nonsense_Mutation	p.Q476*	1
FASTKD3	HNSC	chr5	7867642	7867642	C	G	Silent		1
FASTKD3	READ	chr5	7868038	7868038	G	A	Silent	p.F53F	1
FASTKD3	THYM	chr5	7867694	7867694	T	C	Missense_Mutation	p.K168R	1
FASTKD3	BLCA	chr5	7866908	7866908	C	G	Missense_Mutation		1
FASTKD3	CESC	chr5	7866836	7866836	G	A	Missense_Mutation	p.S454L	1
FASTKD3	LGG	chr5	7867503	7867504	CT	-	Frame_Shift_Del	p.SG231fs	1
FASTKD3	BLCA	chr5	7859577	7859577	G	A	Nonsense_Mutation	p.Q654*	1
FASTKD3	KIRC	chr5	7867988	7867988	C	T	Missense_Mutation	p.G70E	1
FASTKD3	LUSC	chr5	7867058	7867058	C	T	Missense_Mutation	p.R380K	1
FASTKD3	STAD	chr5	7868084	7868084	T	C	Missense_Mutation	p.K38R	1
FASTKD3	HNSC	chr5	7867698	7867698	C	G	Missense_Mutation		1
FASTKD3	SARC	chr5	7868043	7868043	G	T	Missense_Mutation		1
FASTKD3	UCEC	chr5	7867849	7867849	T	C	Silent	p.L116L	1
FASTKD3	BLCA	chr5	7867071	7867071	C	G	Missense_Mutation		1
FASTKD3	COAD	chr5	7861312	7861312	C	A	Nonsense_Mutation	p.E612X	1
FASTKD3	LIHC	chr5	7866870	7866870	A	G	Missense_Mutation		1
FASTKD3	PAAD	chr5	7868079	7868079	G	A	Missense_Mutation		1

Copy number variation (CNV) of FASTKD3
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across FASTKD3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
55902	MESO	TCGA-TS-A7P1-01A	CDKN2A	chr9	21994138	-	FASTKD3	chr5	7866096	-
55902	SARC	TCGA-DX-AB2P-01A	DAB2	chr5	39424906	-	FASTKD3	chr5	7866096	-
55904	SKCM	TCGA-EB-A44R-06A	MTRR	chr5	7897360	+	FASTKD3	chr5	7866096	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	FASTKD3	0.00131198497014447	0.037
HNSC	FASTKD3	0.013893742805347	0.38

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KICH	FASTKD3	0.0102543830932455	0.32
BLCA	FASTKD3	0.00133987237002421	0.044
HNSC	FASTKD3	0.00360955407601274	0.12

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source