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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL24 (NCBI Gene ID:79590)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL24
	Gene ID: 79590
	Gene Symbol	MRPL24
	Gene ID	79590
	Gene Name	mitochondrial ribosomal protein L24
	Synonyms	L24mt\|MRP-L18\|MRP-L24
	Cytomap	1q23.1
	Type of Gene	protein-coding
	Description	39S ribosomal protein L24, mitochondrialmitochondrial large ribosomal subunit protein uL24m
	Modification date	20200313
	UniProtAcc	Q96A35

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPL24	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPL24[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL24	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000361531	156707437	156707568	Frame-shift
ENST00000368211	156707437	156707568	Frame-shift
ENST00000361531	156707822	156707926	Frame-shift
ENST00000368211	156707822	156707926	Frame-shift
ENST00000361531	156708134	156708230	In-frame
ENST00000368211	156708134	156708230	In-frame
ENST00000361531	156708313	156708556	3UTR-3CDS
ENST00000368211	156708313	156708556	3UTR-3CDS

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000361531	156708134	156708230	900	321	416	216	61	93
ENST00000368211	156708134	156708230	900	323	418	216	61	93

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRC	MRPL24	-1.34802117098363	0.000369980864421695
KICH	MRPL24	1.42000841970622	0.00378090143203735
KIRP	MRPL24	-2.9092481117556	0.0139979305677116
LUAD	MRPL24	-3.53731160751159	1.10656371043093e-09
LIHC	MRPL24	1.01230339617377	2.71217975233539e-06
LUSC	MRPL24	-2.80841690659614	7.95689711347621e-09

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
MESO	MRPL24	0.067125341	0.03402487

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL24 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	MRPL24	PMVK	0.81645697	1.51E-12
DLBC	Cell metabolism gene	MRPL24	PSMB3	0.818504074	1.20E-12
DLBC	Cell metabolism gene	MRPL24	SNRPE	0.835025576	1.61E-13
DLBC	Cell metabolism gene	MRPL24	PSMB4	0.843445262	5.31E-14
DLBC	Cell metabolism gene	MRPL24	PSMD4	0.866542239	1.75E-15
DLBC	Epifactor	MRPL24	HMG20B	0.800121436	8.91E-12
DLBC	Epifactor	MRPL24	SIRT6	0.812030981	2.49E-12
DLBC	IUPHAR	MRPL24	SIRT6	0.812030981	2.49E-12
DLBC	IUPHAR	MRPL24	PMVK	0.81645697	1.51E-12
DLBC	TF	MRPL24	HMG20B	0.800121436	8.91E-12
DLBC	TF	MRPL24	THAP4	0.830260317	2.94E-13
DLBC	TSG	MRPL24	PHB	0.800499529	8.56E-12
DLBC	TSG	MRPL24	TSSC4	0.808840689	3.53E-12
DLBC	TSG	MRPL24	SIRT6	0.812030981	2.49E-12
DLBC	TSG	MRPL24	GADD45GIP1	0.832387948	2.25E-13
GBM	Cell metabolism gene	MRPL24	PSMB3	0.805668426	1.66E-40
GBM	Cell metabolism gene	MRPL24	DPM3	0.813218279	8.06E-42
GBM	Cell metabolism gene	MRPL24	PSMB4	0.837061893	2.16E-46
KICH	Cell metabolism gene	MRPL24	MTX1	0.809656696	2.62E-22
KICH	Cell metabolism gene	MRPL24	PSMB6	0.832308943	1.58E-24
KICH	Cell metabolism gene	MRPL24	PSMB3	0.833389935	1.21E-24
KICH	Cell metabolism gene	MRPL24	SSR2	0.852353849	8.66E-27
KICH	CGC	MRPL24	ASPSCR1	0.808854319	3.10E-22
KICH	IUPHAR	MRPL24	PSMB6	0.832308943	1.58E-24
KICH	IUPHAR	MRPL24	CSNK2B	0.852217477	9.00E-27
KIRP	Cell metabolism gene	MRPL24	PSMC5	0.802216752	6.90E-74
KIRP	Cell metabolism gene	MRPL24	PSMB4	0.823366543	5.72E-81
KIRP	Cell metabolism gene	MRPL24	PSMD4	0.834586953	4.02E-85
KIRP	Cell metabolism gene	MRPL24	PSMB3	0.839990771	3.10E-87
KIRP	Cell metabolism gene	MRPL24	MTX1	0.871886011	1.51E-101
LIHC	Cell metabolism gene	MRPL24	PMVK	0.822922333	2.01E-105
LIHC	IUPHAR	MRPL24	PMVK	0.822922333	2.01E-105
PAAD	Cell metabolism gene	MRPL24	SNRPE	0.815858155	6.35E-45
PAAD	Cell metabolism gene	MRPL24	PMVK	0.81670262	4.37E-45
PAAD	Cell metabolism gene	MRPL24	PSMD4	0.826441289	5.01E-47
PAAD	IUPHAR	MRPL24	PMVK	0.81670262	4.37E-45
PCPG	Cell metabolism gene	MRPL24	PSMB4	0.811387107	5.17E-45
PCPG	Cell metabolism gene	MRPL24	MTX1	0.836521176	3.23E-50
PRAD	Cell metabolism gene	MRPL24	SNRPD2	0.803751093	1.12E-125
PRAD	Cell metabolism gene	MRPL24	POLR2F	0.808273187	3.71E-128
PRAD	Cell metabolism gene	MRPL24	PFDN6	0.808764217	1.98E-128
PRAD	Cell metabolism gene	MRPL24	LSM4	0.809611992	6.66E-129
PRAD	Cell metabolism gene	MRPL24	NME1	0.816018645	1.47E-132
PRAD	Cell metabolism gene	MRPL24	HSD17B10	0.829470476	1.01E-140
PRAD	Cell metabolism gene	MRPL24	ATP5G1	0.858407763	5.34E-161
PRAD	Epifactor	MRPL24	TAF10	0.812000821	3.00E-130
PRAD	TSG	MRPL24	NME1	0.816018645	1.47E-132
READ	Cell metabolism gene	MRPL24	PSMB4	0.824806311	2.95E-27
THCA	Cell metabolism gene	MRPL24	PSMC5	0.800617149	6.70E-129
THCA	Cell metabolism gene	MRPL24	PSMB3	0.803892929	9.97E-131
THCA	Cell metabolism gene	MRPL24	PSMB4	0.80572355	9.17E-132
THCA	Cell metabolism gene	MRPL24	PSMB6	0.810040762	2.98E-134
THCA	Cell metabolism gene	MRPL24	DPM3	0.811662839	3.33E-135
THCA	Cell metabolism gene	MRPL24	POLR2J	0.841968651	7.01E-155
THCA	Cell metabolism gene	MRPL24	MTX1	0.860228647	7.24E-169
THCA	CGC	MRPL24	COX6C	0.841186388	2.54E-154
THCA	Epifactor	MRPL24	ZNHIT1	0.824879218	2.57E-143
THCA	IUPHAR	MRPL24	PSMB6	0.810040762	2.98E-134
THCA	TSG	MRPL24	NPRL2	0.812642044	8.79E-136
THCA	TSG	MRPL24	PARK7	0.824099871	8.08E-143
THYM	Cell metabolism gene	MRPL24	PHPT1	0.800038025	2.14E-28
THYM	Cell metabolism gene	MRPL24	MIF	0.800964368	1.67E-28
THYM	Cell metabolism gene	MRPL24	PFDN2	0.803161427	9.19E-29
THYM	Cell metabolism gene	MRPL24	EXOSC4	0.804361088	6.62E-29
THYM	Cell metabolism gene	MRPL24	GPI	0.805821777	4.42E-29
THYM	Cell metabolism gene	MRPL24	TSTA3	0.80973788	1.48E-29
THYM	Cell metabolism gene	MRPL24	MED27	0.819177633	9.42E-31
THYM	Cell metabolism gene	MRPL24	NANS	0.820430294	6.46E-31
THYM	Cell metabolism gene	MRPL24	PYCRL	0.822158285	3.82E-31
THYM	Cell metabolism gene	MRPL24	POLR2I	0.825384211	1.41E-31
THYM	Cell metabolism gene	MRPL24	TPI1	0.829761454	3.53E-32
THYM	Cell metabolism gene	MRPL24	DPM3	0.829884638	3.40E-32
THYM	Cell metabolism gene	MRPL24	ALDOA	0.831950983	1.74E-32
THYM	Cell metabolism gene	MRPL24	GEMIN7	0.835737283	5.00E-33
THYM	Cell metabolism gene	MRPL24	WBSCR22	0.836838532	3.46E-33
THYM	Cell metabolism gene	MRPL24	GSTZ1	0.838325109	2.09E-33
THYM	Cell metabolism gene	MRPL24	NME2	0.843265399	3.79E-34
THYM	Cell metabolism gene	MRPL24	FH	0.850121141	3.21E-35
THYM	Cell metabolism gene	MRPL24	BCS1L	0.854624867	5.93E-36
THYM	Cell metabolism gene	MRPL24	FLAD1	0.867337785	3.63E-38
THYM	Cell metabolism gene	MRPL24	PSMD4	0.869057343	1.75E-38
THYM	Cell metabolism gene	MRPL24	MTX1	0.871362124	6.48E-39
THYM	Cell metabolism gene	MRPL24	PPOX	0.871782177	5.40E-39
THYM	Cell metabolism gene	MRPL24	CYC1	0.873115744	3.00E-39
THYM	Cell metabolism gene	MRPL24	PSMB4	0.876847714	5.62E-40
THYM	Cell metabolism gene	MRPL24	PMVK	0.885100982	1.13E-41
THYM	Cell metabolism gene	MRPL24	ATP5G1	0.894327044	9.87E-44
THYM	CGC	MRPL24	COX6C	0.815188823	3.07E-30
THYM	CGC	MRPL24	FH	0.850121141	3.21E-35
THYM	Epifactor	MRPL24	EXOSC4	0.804361088	6.62E-29
THYM	Epifactor	MRPL24	CDK5	0.806069278	4.13E-29
THYM	IUPHAR	MRPL24	CDK5	0.806069278	4.13E-29
THYM	IUPHAR	MRPL24	ABCB8	0.818551731	1.14E-30
THYM	IUPHAR	MRPL24	ATP6V0E1	0.8313109	2.14E-32
THYM	IUPHAR	MRPL24	PMVK	0.885100982	1.13E-41
THYM	Kinase	MRPL24	CDK5	0.806069278	4.13E-29
THYM	Kinase	MRPL24	FASTK	0.886487623	5.68E-42
THYM	TF	MRPL24	ZNF692	0.828408043	5.44E-32
THYM	TF	MRPL24	NME2	0.843265399	3.79E-34
THYM	TSG	MRPL24	FH	0.850121141	3.21E-35
THYM	TSG	MRPL24	STUB1	0.857840691	1.71E-36
UCEC	Cell metabolism gene	MRPL24	MTX1	0.820562143	3.10E-50
UCS	Cell metabolism gene	MRPL24	PHPT1	0.800038025	2.14E-28
UCS	Cell metabolism gene	MRPL24	MIF	0.800964368	1.67E-28
UCS	Cell metabolism gene	MRPL24	PFDN2	0.803161427	9.19E-29
UCS	Cell metabolism gene	MRPL24	EXOSC4	0.804361088	6.62E-29
UCS	Cell metabolism gene	MRPL24	GPI	0.805821777	4.42E-29
UCS	Cell metabolism gene	MRPL24	TSTA3	0.80973788	1.48E-29
UCS	Cell metabolism gene	MRPL24	MED27	0.819177633	9.42E-31
UCS	Cell metabolism gene	MRPL24	NANS	0.820430294	6.46E-31
UCS	Cell metabolism gene	MRPL24	PYCRL	0.822158285	3.82E-31
UCS	Cell metabolism gene	MRPL24	POLR2I	0.825384211	1.41E-31
UCS	Cell metabolism gene	MRPL24	TPI1	0.829761454	3.53E-32
UCS	Cell metabolism gene	MRPL24	DPM3	0.829884638	3.40E-32
UCS	Cell metabolism gene	MRPL24	ALDOA	0.831950983	1.74E-32
UCS	Cell metabolism gene	MRPL24	GEMIN7	0.835737283	5.00E-33
UCS	Cell metabolism gene	MRPL24	WBSCR22	0.836838532	3.46E-33
UCS	Cell metabolism gene	MRPL24	GSTZ1	0.838325109	2.09E-33
UCS	Cell metabolism gene	MRPL24	NME2	0.843265399	3.79E-34
UCS	Cell metabolism gene	MRPL24	FH	0.850121141	3.21E-35
UCS	Cell metabolism gene	MRPL24	BCS1L	0.854624867	5.93E-36
UCS	Cell metabolism gene	MRPL24	FLAD1	0.867337785	3.63E-38
UCS	Cell metabolism gene	MRPL24	PSMD4	0.869057343	1.75E-38
UCS	Cell metabolism gene	MRPL24	MTX1	0.871362124	6.48E-39
UCS	Cell metabolism gene	MRPL24	PPOX	0.871782177	5.40E-39
UCS	Cell metabolism gene	MRPL24	CYC1	0.873115744	3.00E-39
UCS	Cell metabolism gene	MRPL24	PSMB4	0.876847714	5.62E-40
UCS	Cell metabolism gene	MRPL24	PMVK	0.885100982	1.13E-41
UCS	Cell metabolism gene	MRPL24	ATP5G1	0.894327044	9.87E-44
UCS	CGC	MRPL24	COX6C	0.815188823	3.07E-30
UCS	CGC	MRPL24	FH	0.850121141	3.21E-35
UCS	Epifactor	MRPL24	EXOSC4	0.804361088	6.62E-29
UCS	Epifactor	MRPL24	CDK5	0.806069278	4.13E-29
UCS	IUPHAR	MRPL24	CDK5	0.806069278	4.13E-29
UCS	IUPHAR	MRPL24	ABCB8	0.818551731	1.14E-30
UCS	IUPHAR	MRPL24	ATP6V0E1	0.8313109	2.14E-32
UCS	IUPHAR	MRPL24	PMVK	0.885100982	1.13E-41
UCS	Kinase	MRPL24	CDK5	0.806069278	4.13E-29
UCS	Kinase	MRPL24	FASTK	0.886487623	5.68E-42
UCS	TF	MRPL24	ZNF692	0.828408043	5.44E-32
UCS	TF	MRPL24	NME2	0.843265399	3.79E-34
UCS	TSG	MRPL24	FH	0.850121141	3.21E-35
UCS	TSG	MRPL24	STUB1	0.857840691	1.71E-36
UVM	Cell metabolism gene	MRPL24	MTX1	0.867259434	2.45E-25
UVM	Epifactor	MRPL24	RUVBL2	0.802326537	3.69E-19
UVM	TSG	MRPL24	GADD45GIP1	0.813349377	4.93E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	MRPL24	MRPL9	1.16888038960038	0.000120222568511963
STAD	MRPL24	MRPL15	-2.15546608137429	0.000334546435624361
KIRC	MRPL24	MRPL11	-1.04966837625557	0.000354478033746394
LIHC	MRPL24	MRPL13	1.54402472107614	0.000655351190157038
ESCA	MRPL24	MRPL47	-2.26373711796715	0.001953125
CHOL	MRPL24	MRPL3	-2.68429255990621	0.00390625
ESCA	MRPL24	MRPL3	-4.97897094908275	0.0048828125
COAD	MRPL24	MRPL15	1.17181689924568	0.00513318181037904
ESCA	MRPL24	MRPL13	-1.07746088474995	0.0068359375
COAD	MRPL24	MRPL47	-2.29582381838246	0.00863465666770936
ESCA	MRPL24	MRPL17	-1.18756178214998	0.009765625
STAD	MRPL24	MRPL47	-1.4008685687155	0.0118026207201183
STAD	MRPL24	MRPL9	-1.54523483458273	0.0118026207201183
LIHC	MRPL24	MRPL17	-1.06225729770915	0.0124123499319886
STAD	MRPL24	MRPL4	1.4393539135682	0.0279771662317216
LIHC	MRPL24	MRPL47	-6.59586850948538	0.0416658979324166
KIRC	MRPL24	MRPL47	1.74758475364701	1.00533732476669e-06
PRAD	MRPL24	MRPL11	1.12581653394628	1.15996224044503e-05
KICH	MRPL24	MRPL15	1.54522142310359	1.19209289550781e-07
LUSC	MRPL24	MRPL21	-4.98277643789037	1.45947399043856e-08
STAD	MRPL24	MRPL17	-3.90880705449186	1.49570405483246e-06
LUSC	MRPL24	MRPL15	-4.43702988385305	1.91594862886626e-08
KIRC	MRPL24	MRPL3	1.69955762234244	1.97132191719422e-08
COAD	MRPL24	MRPL4	2.77705897514473	2.98023223876954e-07
PRAD	MRPL24	MRPL37	-2.21074342735295	3.65283830814974e-07
LUAD	MRPL24	MRPL37	-2.86549200993971	3.76287422734829e-10
BRCA	MRPL24	MRPL15	-3.82448964360727	5.49451113259074e-14
LUAD	MRPL24	MRPL21	-1.86897497221853	6.16191557420719e-07
LUSC	MRPL24	MRPL17	-6.83409683292749	6.93230040561614e-07
BRCA	MRPL24	MRPL21	-1.5345447607194	7.40794680786486e-08
BRCA	MRPL24	MRPL37	-3.79079551418026	9.33185484212232e-10
LUAD	MRPL24	MRPL47	-1.74990909879567	9.53955602455483e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL24

ICT1, Ybx1, CUL3, APP, MRPL44, MRPL37, MRPL39, MRPL4, MRPL40, MRPL45, MRPL19, MRPL51, MRPL2, MRPL13, MRPL21, MRPS5, TMEM177, TSR1, TUFM, RPS15, ABCC2, ILF2, C19orf70, ERLEC1, NPM1, GRSF1, AURKA, TP53, NXF1, BTRC, MRPL28, RPL6, RPS8, MRPS30, MRPL47, HNRNPA1, NTRK1, MRPL18, MRPL22, POLR3A, RPL11, RPS11, RPS18, RPS5, MRPL38, MRPL46, MRPL9, MRPS10, RPL17, RPL8, CENPE, RBM4, SORT1, MRPL50, Tnks, Kctd5, Cenpf, Brwd3, FOXB1, FOXL2, RC3H1, DUSP11, MRPL10, MRPL42, MRPL41, RPL18, LEO1, MED24, TRIM14, LARP7, HEXIM1, MEPCE, RECQL4, MB21D1, REST, RPS6, MRM1, HSPD1, PDK1, TRMT61B, AURKAIP1, LTN1, NR2C2, SNRNP70, TRIM28, PLEKHA4, ENG, RASA1, SH3GL3, EMC2, SNIP1, HTRA2, IMMP2L, ZC3HAV1, ACAD9, AUH, C12orf65, C17orf80, C1QBP, C21orf33, C6orf203, C8orf82, CHCHD1, CS, DDX28, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, LRPPRC, MCU, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRPS26, MRRF, MTERF3, MTFMT, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, PMPCA, PMPCB, RPUSD4, SLC25A12, SSBP1, TACO1, TBRG4, TEFM, TFAM, TMEM70, TRUB2, TSFM, EXD2, BCAR1, DNAJC15, HSCB, SMYD3, MRPL23, C14orf169, DDRGK1, AARS2, COX8A, PDHA1, TRAP1, YBX2, RPL13A, RPL27A, ABT1, ZNF467, SRSF5, RPS9, YBX1, RPL37, RPL32, MALSU1, MRPL53, MRPL52, HNRNPU, SRSF3, MRPL33, H1FNT, MRPL30, RPL19, LIN28A, SRSF4, RPL26, RBMS2, GADD45GIP1, MRPS18A, FAHD1, ZNF574, RPL10, PRR3, MRPL27, APOBEC3D, MRPL12, RPL35, RPL36AL, KLF15, BRD4,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPL24	KIRC	chr1	156708444	156708445	-	G	Frame_Shift_Ins	p.L18fs	14
MRPL24	LIHC	chr1	156708445	156708445	G	-	Frame_Shift_Del	p.H18fs	6
MRPL24	BRCA	chr1	156708153	156708153	G	A	Silent	p.V87	3
MRPL24	LIHC	chr1	156708387	156708387	G	-	Frame_Shift_Del	p.P37fs	3
MRPL24	SARC	chr1	156707852	156707852	G	T	Silent		2
MRPL24	UCEC	chr1	156708373	156708373	G	A	Missense_Mutation	p.R42C	2
MRPL24	SKCM	chr1	156708369	156708369	G	A	Missense_Mutation	p.P43L	2
MRPL24	UCEC	chr1	156708395	156708395	C	A	Missense_Mutation	p.K34N	2
MRPL24	SKCM	chr1	156708370	156708370	G	A	Missense_Mutation	p.P43S	2
MRPL24	UCEC	chr1	156708492	156708492	C	T	Missense_Mutation	p.R2H	2
MRPL24	HNSC	chr1	156708205	156708205	G	A	Missense_Mutation	p.A70V	2
MRPL24	LIHC	chr1	156708481	156708481	G	-	Frame_Shift_Del	p.L7fs	2
MRPL24	BRCA	chr1	156707244	156707244	C	G	Missense_Mutation	p.M199I	2
MRPL24	STAD	chr1	156708136	156708136	G	A	Missense_Mutation		2
MRPL24	STAD	chr1	156707482	156707482	G	T	Missense_Mutation	p.P157H	2
MRPL24	LUAD	chr1	156708225	156708225	C	A	Missense_Mutation	p.E63D	2
MRPL24	ESCA	chr1	156707313	156707313	G	T	Missense_Mutation		1
MRPL24	STAD	chr1	156708136	156708136	G	A	Splice_Site	p.T93_splice	1
MRPL24	LUAD	chr1	156708444	156708445	-	G	Frame_Shift_Ins	p.H18fs	1
MRPL24	ESCA	chr1	156707313	156707313	G	T	Missense_Mutation	p.D176E	1
MRPL24	THCA	chr1	156707511	156707511	G	T	Silent		1
MRPL24	KIRP	chr1	156707893	156707893	G	A	Missense_Mutation	p.R105W	1
MRPL24	HNSC	chr1	156708372	156708372	C	T	Missense_Mutation		1
MRPL24	UCEC	chr1	156707525	156707525	G	A	Missense_Mutation	p.R143W	1
MRPL24	KIRP	chr1	156707893	156707893	G	A	Missense_Mutation		1
MRPL24	BLCA	chr1	156707480	156707480	C	T	Missense_Mutation		1
MRPL24	SARC	chr1	156707852	156707852	G	T	Silent	p.R118R	1
MRPL24	HNSC	chr1	156708490	156708490	G	A	Missense_Mutation		1
MRPL24	LGG	chr1	156708198	156708198	C	T	Silent	p.K72K	1
MRPL24	BLCA	chr1	156708489	156708489	A	G	Missense_Mutation		1
MRPL24	HNSC	chr1	156708490	156708490	G	A	Missense_Mutation	p.L3F	1
MRPL24	LGG	chr1	156708198	156708198	C	T	Missense_Mutation		1
MRPL24	BLCA	chr1	156707480	156707480	C	T	Missense_Mutation	p.E158K	1
MRPL24	HNSC	chr1	156708372	156708372	C	T	Missense_Mutation	p.R42H	1
MRPL24	BLCA	chr1	156708489	156708489	A	G	Missense_Mutation	p.L3P	1
MRPL24	SKCM	chr1	156708203	156708203	C	A	Missense_Mutation	p.G71W	1
MRPL24	KICH	chr1	156708172	156708172	C	T	Missense_Mutation		1
MRPL24	LIHC	chr1	156707447	156707447	T	-	Frame_Shift_Del	p.T169fs	1
MRPL24	STAD	chr1	156708445	156708445	G	-	Frame_Shift_Del		1
MRPL24	KICH	chr1	156708172	156708172	C	T	Missense_Mutation	p.R81Q	1
MRPL24	LIHC	chr1	156708319	156708319	C	-	Frame_Shift_Del	p.D60fs	1
MRPL24	COAD	chr1	156708388	156708388	G	T	Missense_Mutation	p.P37T	1
MRPL24	STAD	chr1	156708136	156708136	G	A	Missense_Mutation	p.T93I	1
MRPL24	KIRC	chr1	156708371	156708371	G	T	Silent	p.R42R	1
MRPL24	ESCA	chr1	156707997	156707997	C	G	RNA	NULL	1
MRPL24	KIRC	chr1	156708372	156708372	C	G	Missense_Mutation	p.R42P	1

Copy number variation (CNV) of MRPL24
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Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL24
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Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
98961	LGG	TCGA-TM-A84J-01A	MRPL24	chr1	156707438	-	CCT3	chr1	156294880	-
100459	N/A	EC454675	MRPL24	chr1	156709705	-	FAM175A	chr4	84386660	+
86595	STAD	TCGA-HU-A4GP	MRPL24	chr1	156710803	-	LMO4	chr1	87810470	+
73421	N/A	AA807817	PRKCB	chr16	24173789	+	MRPL24	chr1	156707095	+
73424	STAD	TCGA-HF-A5NB	REG4	chr1	120354031	-	MRPL24	chr1	156708556	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	MRPL24	0.00243857600857316	0.068
ESCA	MRPL24	0.0222405519242363	0.6

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	MRPL24	0.0120449958913746	0.35
THCA	MRPL24	0.000411507532141936	0.013
KIRC	MRPL24	0.0167513936465809	0.47
KICH	MRPL24	0.0457605909425107	1
LGG	MRPL24	7.13972583173363e-05	0.0024
BRCA	MRPL24	0.00267915616140283	0.083
PAAD	MRPL24	0.00640758003763714	0.19
SARC	MRPL24	0.0210409203376053	0.57

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source