Home

Download

Statistics

Examples

Help

Contact

	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: TARS2 (NCBI Gene ID:80222)

Gene Summary

Gene Summary

Gene Information	Gene Name: TARS2
	Gene ID: 80222
	Gene Symbol	TARS2
	Gene ID	80222
	Gene Name	threonyl-tRNA synthetase 2, mitochondrial
	Synonyms	COXPD21\|TARSL1\|thrRS
	Cytomap	1q21.2
	Type of Gene	protein-coding
	Description	threonine--tRNA ligase, mitochondrialthreonyl-tRNA synthetase 2, mitochondrial (putative)threonyl-tRNA synthetase-like 1
	Modification date	20200313
	UniProtAcc	Q9BW92

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0006418	tRNA aminoacylation for protein translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
TARS2	>1119.25

Top

Translation Studies in PubMed

We searched PubMed using 'TARS2[title] AND translation [title] AND human.'

Gene	Title	PMID
TARS2	.	.

Top

Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000369064	150463076	150463201	Frame-shift
ENST00000369064	150464073	150464138	Frame-shift
ENST00000369064	150468957	150469104	In-frame
ENST00000369064	150469285	150469384	In-frame
ENST00000369064	150470005	150470223	Frame-shift
ENST00000369064	150471372	150471510	In-frame
ENST00000369064	150477107	150477209	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000369064	150468957	150469104	2746	809	955	718	258	307
ENST00000369064	150469285	150469384	2746	956	1054	718	307	340
ENST00000369064	150471372	150471510	2746	1436	1573	718	467	513
ENST00000369064	150477107	150477209	2746	1753	1854	718	573	606

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9BW92	258	307	211	340	Alternative sequence	ID=VSP_054537;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9BW92	307	340	211	340	Alternative sequence	ID=VSP_054537;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9BW92	258	307	282	282	Natural variant	ID=VAR_071853;Note=In COXPD21%3B decreased expression at mRNA and protein levels%3B decreased threonine-tRNA ligase activity%3B affects both Thr activation and transfer%3B decreased aminoacyl-tRNA editing activity%3B decreased protein stability%3B loss of homodimerization. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:24827421,ECO:0000269\|PubMed:26811336;Dbxref=dbSNP:rs587777593,PMID:24827421,PMID:26811336
Q9BW92	258	307	269	269	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9BW92	573	606	579	579	Sequence conflict	Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305

Top

Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
STAD	TARS2	-1.38306148381397	0.000605844426900149
KIRC	TARS2	-1.19446373783939	0.000920685873282556
COAD	TARS2	-4.40729007621633	2.08616256713867e-07
LUSC	TARS2	-8.52359948969235	8.03131069907519e-10

Top

Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
ESCA	TARS2	0.07187794	0.018524776
SARC	TARS2	-0.194592363	0.032525724
MESO	TARS2	0.091571418	0.044178612

Top

Associated Genes

Strongly correlated genes belong to cellular important gene groups with TARS2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
THYM	Cell metabolism gene	TARS2	EPRS	0.81921372	9.32E-31
THYM	IUPHAR	TARS2	ADIPOR1	0.804271036	6.78E-29
UCEC	Epifactor	TARS2	ZNF687	0.817772127	1.24E-49
UCEC	TF	TARS2	ZNF687	0.817772127	1.24E-49
UCS	Cell metabolism gene	TARS2	EPRS	0.81921372	9.32E-31
UCS	IUPHAR	TARS2	ADIPOR1	0.804271036	6.78E-29

Top

Protein structure

Protein 3D structure
Visit iCn3D.

Top

Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	TARS2	LARS2	-3.14243034518345	0.00019507110118866
STAD	TARS2	YARS	-6.49411565641968	0.000280400272458792
KIRP	TARS2	PARS2	1.16452168188224	0.000471815001219511
LUSC	TARS2	LARS	-1.72121981954749	0.000480107205471704
HNSC	TARS2	YARS	1.29642872422682	0.000481783007217019
THCA	TARS2	LARS2	1.46480152873302	0.000495104848866816
STAD	TARS2	AARS	-1.37044043826934	0.000657554250210524
STAD	TARS2	EPRS	-1.48171581324647	0.000789262883452143
COAD	TARS2	VARS2	-1.9742286061776	0.00160405039787293
BLCA	TARS2	PARS2	-2.53947468245316	0.002838134765625
CHOL	TARS2	MARS	-4.58890181072108	0.00390625
KIRP	TARS2	VARS2	1.53424323702797	0.0099095250479877
CHOL	TARS2	IARS	-2.92341608141499	0.01171875
KIRC	TARS2	VARS2	-2.2512103536863	0.0136501968701345
READ	TARS2	VARS2	-1.67590407896013	0.03125
STAD	TARS2	IARS2	-1.36774073274524	0.0324882394634187
HNSC	TARS2	VARS2	1.83480983015328	0.0410440647583528
STAD	TARS2	VARS2	-1.13178695534752	0.0433286507613957
PRAD	TARS2	PARS2	-1.46158282673459	0.0436765184075403
LUAD	TARS2	PARS2	-3.49187010929807	1.06715530949094e-10
LIHC	TARS2	LARS	-1.57612943170265	1.09871251804152e-08
BRCA	TARS2	LARS2	-5.48583270161281	1.12177735729832e-06
LUAD	TARS2	LARS	-1.89171706205171	1.25525807323939e-06
THCA	TARS2	YARS	-1.52851760350795	1.38467683131598e-09
LUAD	TARS2	VARS2	-1.31763611553633	1.50488235365288e-05
LUSC	TARS2	VARS2	-2.0631115960123	1.58535966576384e-05
LIHC	TARS2	EPRS	-7.10731017811505	2.28054594243154e-08
BRCA	TARS2	IARS2	1.50870900515201	2.53632294696759e-14
LUAD	TARS2	LARS2	-1.17851720308655	2.81164525558733e-06
KICH	TARS2	YARS	-2.00632816869948	2.98023223876953e-07
LUSC	TARS2	PARS2	-2.93653902690081	3.1117120779415e-08
LIHC	TARS2	IARS	-1.16847098939898	3.43009058766818e-06
BRCA	TARS2	YARS	-2.58863291399932	3.63754942015711e-21
KICH	TARS2	LARS2	1.44112931619469	4.17232513427734e-06
LUAD	TARS2	AARS	-6.1139400689607	4.40386642176516e-08
BRCA	TARS2	MARS	-2.42525133735396	4.72741245870012e-27
LIHC	TARS2	MARS	-3.13394077995853	7.36800472650994e-09
KIRP	TARS2	MARS	-1.35870938193596	7.40401446819306e-05
BRCA	TARS2	VARS2	-1.40803061639365	8.81390355292883e-14
PRAD	TARS2	EPRS	-1.76339127457265	9.52775218277559e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with TARS2

ICT1, CUL3, AHSA1, CDC37, CHORDC1, FKBPL, EGFR, NTRK1, Mad2l2, COQ9, CISD3, C2orf47, PTPN18, HNRNPL, CFTR, EGLN3, CDC34, BPLF1, ESR2, RECQL4, HSPD1, PDK1, AMBRA1, PHB, APEX1, SNRNP70, M, BIRC3, STAU1, LMBR1L, SYPL1, FKBP7, SLC17A9, PLIN3, ASB6, ARL6IP1, TNFRSF10D, TARSL2, HOMEZ, PLEKHA4, ORF8b, nsp12, nsp7, HSCB, ZFP36, LZTS2, MEX3B, TRIM56, AUH, C12orf65, C21orf33, C6orf203, MCUR1, CS, HAX1, HINT2, METTL17, MRPS12, MRRF, MTG2, MTIF2, MTRF1L, RMND1, SSBP1, TEFM, TUFM, EXD2, CLPP, UBR5, Apc2, nsp10, DNAJA2, DNAJC7, LRRC61, KDF1, TULP3, DDRGK1, AARS2, AIFM1, AKAP1, ANAPC2, COX4I1, LAMTOR1, LCK, PDHA1, PRPH, TRAP1, RASL10B, YARS2, MRPS17, DHRS2, LDHAL6B, P2RY8, MRPS30, NAA38, F12, NIPSNAP3B, TRMU, SLC25A10, TRIM43, MRPS24, ACSM5, CBR4, MYL10, QRSL1, AK4, C20orf96, OXCT2, ADAM7, GPR45, TNFSF14, UQCRFS1, SHC2, AMACR, GPR182, GCAT, GPR55, HLA-C, NDUFS7, KLRB1, FAHD1, MRPS2, NIPSNAP3A, WDR83, SPRTN,

Top

Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
TARS2	chr1	150459692	GA	G	Deletion	Benign	not_provided
TARS2	chr1	150459715	T	C	single_nucleotide_variant	Benign	not_provided
TARS2	chr1	150459886	C	T	single_nucleotide_variant	Likely_benign	not_specified
TARS2	chr1	150459893	CTGTT	C	Deletion	Benign	not_specified\|not_provided	SO:0002153\|genic_upstream_transcript_variant	SO:0002153\|genic_upstream_transcript_variant
TARS2	chr1	150459905	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
TARS2	chr1	150459975	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150460127	T	TCTAA	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150460168	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150460348	C	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TARS2	chr1	150460368	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150460408	A	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TARS2	chr1	150460538	G	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150461502	G	A	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_21	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150461542	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TARS2	chr1	150461569	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150461761	AC	A	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150461801	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150461873	G	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150462791	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150462811	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150462903	T	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150463067	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150463076	G	C	single_nucleotide_variant	Uncertain_significance	Neurodevelopmental_disorder	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
TARS2	chr1	150463109	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TARS2	chr1	150463526	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150463530	C	CAA	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150463530	CA	C	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150463537	AAAAC	A	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150463588	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150463772	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150463919	C	A	single_nucleotide_variant	Benign/Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150464141	A	G	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_21	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150464268	AT	A	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150464331	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150464437	G	GTT	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150464437	G	GTTT	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150464437	GTT	G	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150464437	GTTTTTTTTTT	G	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150464603	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150464913	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
TARS2	chr1	150464927	C	T	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_21	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
TARS2	chr1	150464964	C	T	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_21	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
TARS2	chr1	150464973	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150468842	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150468984	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
TARS2	chr1	150469028	C	T	single_nucleotide_variant	Pathogenic/Likely_pathogenic	Combined_oxidative_phosphorylation_deficiency_21	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
TARS2	chr1	150469070	A	G	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_21	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
TARS2	chr1	150469083	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
TARS2	chr1	150469256	G	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150469297	C	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
TARS2	chr1	150469332	T	G	single_nucleotide_variant	Likely_pathogenic	Combined_oxidative_phosphorylation_deficiency_21	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
TARS2	chr1	150469375	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
TARS2	chr1	150469399	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150469480	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150469993	C	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150470019	A	G	single_nucleotide_variant	Benign/Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150470021	C	T	single_nucleotide_variant	Uncertain_significance	Neurodevelopmental_disorder	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150470061	C	T	single_nucleotide_variant	Benign	not_specified	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150470116	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TARS2	chr1	150470145	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150470182	A	G	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TARS2	chr1	150470192	G	A	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_21	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150470296	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150470322	C	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150470478	C	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150470479	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150470964	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150470990	C	T	single_nucleotide_variant	Benign/Likely_benign	not_specified\|not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TARS2	chr1	150471013	A	G	single_nucleotide_variant	Likely_pathogenic	Combined_oxidative_phosphorylation_deficiency_21	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150471024	C	T	single_nucleotide_variant	Likely_pathogenic	Combined_oxidative_phosphorylation_deficiency_21	SO:0001587\|nonsense,SO:0001619\|non-coding_transcript_variant	SO:0001587\|nonsense,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150471056	C	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TARS2	chr1	150471083	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TARS2	chr1	150471092	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TARS2	chr1	150471093	C	T	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_21\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150471156	C	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150471157	T	A	single_nucleotide_variant	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150471424	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150471443	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150471679	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150471848	A	AT	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150471935	G	GT	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150476516	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150476786	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150476806	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150476871	G	C	single_nucleotide_variant	Likely_pathogenic	Combined_oxidative_phosphorylation_deficiency_21	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150477061	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150477085	A	AC	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150477088	C	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150477091	C	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150477092	C	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150477092	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150477145	C	T	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001587\|nonsense,SO:0001619\|non-coding_transcript_variant	SO:0001587\|nonsense,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150477201	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TARS2	chr1	150477250	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150477399	C	T	single_nucleotide_variant	Likely_pathogenic	Combined_oxidative_phosphorylation_deficiency_21	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150477840	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TARS2	chr1	150479435	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TARS2	chr1	150479486	G	A	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TARS2	chr1	150479523	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
TARS2	chr1	150479525	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
TARS2	chr1	150479747	C	CA	Duplication	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant
TARS2	chr1	150479842	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
TARS2	LUAD	chr1	150463952	150463952	G	A	Missense_Mutation	p.E199K	6
TARS2	KIRC	chr1	150476838	150476838	G	A	Missense_Mutation	p.G549S	5
TARS2	LUAD	chr1	150470105	150470105	G	A	Missense_Mutation	p.D374N	5
TARS2	CESC	chr1	150469344	150469344	G	A	Missense_Mutation		4
TARS2	BRCA	chr1	150476814	150476814	G	C	Missense_Mutation	p.D541H	3
TARS2	SKCM	chr1	150471471	150471471	C	T	Silent	p.G500G	3
TARS2	COAD	chr1	150469374	150469374	C	T	Missense_Mutation	p.A337V	3
TARS2	BRCA	chr1	150479529	150479529	G	A	Missense_Mutation	p.E716K	3
TARS2	BLCA	chr1	150477198	150477198	C	T	Silent	p.C603C	3
TARS2	ESCA	chr1	150470031	150470031	C	G	Missense_Mutation	p.S349C	3
TARS2	HNSC	chr1	150478094	150478094	C	A	Missense_Mutation	p.L641M	3
TARS2	UCEC	chr1	150479465	150479465	G	T	Missense_Mutation	p.W694C	3
TARS2	BLCA	chr1	150463973	150463973	C	T	Missense_Mutation	p.R206C	3
TARS2	UCEC	chr1	150471415	150471415	G	A	Missense_Mutation	p.V482I	3
TARS2	KIRC	chr1	150459930	150459930	G	A	Missense_Mutation	p.A2T	3
TARS2	BRCA	chr1	150469292	150469292	G	A	Missense_Mutation	p.E310K	3
TARS2	BLCA	chr1	150463973	150463973	C	T	Missense_Mutation		3
TARS2	BRCA	chr1	150470165	150470165	T	C	Missense_Mutation	p.S394P	3
TARS2	STAD	chr1	150470192	150470192	G	A	Missense_Mutation	p.A403T	3
TARS2	CESC	chr1	150469344	150469344	G	A	Missense_Mutation	p.R327Q	3
TARS2	BRCA	chr1	150471122	150471122	C	G	Missense_Mutation	p.I461M	3
TARS2	LUAD	chr1	150477190	150477190	G	A	Missense_Mutation	p.E601K	3
TARS2	BRCA	chr1	150471489	150471489	C	T	Silent	p.C506	3
TARS2	SKCM	chr1	150471505	150471505	G	A	Missense_Mutation	p.E512K	2
TARS2	UCEC	chr1	150461641	150461641	C	A	Missense_Mutation	p.F155L	2
TARS2	LUAD	chr1	150479448	150479448	C	T	Missense_Mutation	p.R689C	2
TARS2	BLCA	chr1	150459941	150459941	G	C	Missense_Mutation	p.Q5H	2
TARS2	SARC	chr1	150463910	150463910	T	A	Nonsense_Mutation	p.L143*	2
TARS2	STAD	chr1	150463946	150463946	A	G	Missense_Mutation	p.R197G	2
TARS2	LIHC	chr1	150469064	150469064	G	-	Frame_Shift_Del	p.R294fs	2
TARS2	UCEC	chr1	150463122	150463122	C	G	Missense_Mutation	p.Q145E	2
TARS2	BLCA	chr1	150463886	150463886	G	C	Missense_Mutation	p.E177Q	2
TARS2	STAD	chr1	150477205	150477205	A	G	Missense_Mutation	p.K606E	2
TARS2	SKCM	chr1	150469306	150469306	C	T	Silent	p.F314F	2
TARS2	UCEC	chr1	150470076	150470076	A	G	Missense_Mutation	p.Q364R	2
TARS2	BLCA	chr1	150471769	150471769	G	T	Splice_Site	p.K539N	2
TARS2	STAD	chr1	150476902	150476902	A	G	Missense_Mutation	p.Q570R	2
TARS2	CESC	chr1	150463113	150463113	G	A	Missense_Mutation		2
TARS2	ESCA	chr1	150463878	150463878	G	T	Missense_Mutation	p.R174L	2
TARS2	LIHC	chr1	150461451	150461451	C	G	Missense_Mutation	p.A92G	2
TARS2	SKCM	chr1	150463152	150463152	C	T	Missense_Mutation	p.P155S	2
TARS2	BLCA	chr1	150463082	150463082	C	G	Missense_Mutation	p.F131L	2
TARS2	UCEC	chr1	150470083	150470083	G	A	Silent	p.G366	2
TARS2	PRAD	chr1	150468986	150468986	G	T	Missense_Mutation	p.G268V	2
TARS2	BLCA	chr1	150478109	150478109	G	C	Missense_Mutation	p.D646H	2
TARS2	SKCM	chr1	150471474	150471474	C	T	Silent	p.F501F	2
TARS2	STAD	chr1	150469093	150469093	C	T	Missense_Mutation	p.R304C	2
TARS2	LIHC	chr1	150470997	150470997	C	-	Frame_Shift_Del	p.P420fs	2
TARS2	SKCM	chr1	150469026	150469026	C	T	Silent	p.F281F	2
TARS2	UCEC	chr1	150471057	150471057	G	A	Missense_Mutation	p.E440K	2
TARS2	LIHC	chr1	150470188	150470188	A	G	Silent		2
TARS2	PRAD	chr1	150471026	150471026	A	G	Silent	p.R429R	2
TARS2	SKCM	chr1	150463090	150463090	C	T	Missense_Mutation	p.S134F	2
TARS2	STAD	chr1	150460423	150460423	C	T	Silent	p.S52S	2
TARS2	CESC	chr1	150477120	150477120	C	T	Silent		2
TARS2	ESCA	chr1	150470031	150470031	C	G	Missense_Mutation		2
TARS2	LIHC	chr1	150471039	150471039	G	-	Frame_Shift_Del	p.G434fs	2
TARS2	UCEC	chr1	150471733	150471733	C	A	Missense_Mutation	p.D527E	2
TARS2	LIHC	chr1	150461451	150461451	C	G	Missense_Mutation		2
TARS2	STAD	chr1	150471768	150471768	A	C	Missense_Mutation		2
TARS2	STAD	chr1	150476841	150476841	C	T	Missense_Mutation	p.R550W	2
TARS2	CESC	chr1	150477452	150477452	G	C	Missense_Mutation		2
TARS2	LIHC	chr1	150471743	150471743	G	-	Frame_Shift_Del	p.G531fs	2
TARS2	LUAD	chr1	150469316	150469316	A	T	Missense_Mutation	p.S318C	2
TARS2	UCEC	chr1	150477198	150477198	C	T	Silent	p.C603	2
TARS2	BRCA	chr1	150469022	150469022	C	T	Missense_Mutation	p.S280F	2
TARS2	STAD	chr1	150463135	150463135	C	A	Missense_Mutation		2
TARS2	SKCM	chr1	150471438	150471438	C	T	Silent	p.S489S	2
TARS2	STAD	chr1	150463092	150463092	A	G	Missense_Mutation	p.S135G	2
TARS2	LIHC	chr1	150477199	150477199	G	-	Frame_Shift_Del	p.G605fs	2
TARS2	SKCM	chr1	150471004	150471004	C	T	Missense_Mutation	p.S422F	2
TARS2	UCEC	chr1	150460464	150460464	C	A	Missense_Mutation	p.P66H	2
TARS2	BLCA	chr1	150463184	150463184	C	A	Missense_Mutation	p.F165L	2
TARS2	UCEC	chr1	150479529	150479529	G	T	Nonsense_Mutation	p.E716*	2
TARS2	STAD	chr1	150477184	150477184	C	T	Silent		2
TARS2	SKCM	chr1	150468960	150468960	C	G	Missense_Mutation	p.N259K	2
TARS2	CESC	chr1	150463113	150463113	G	A	Missense_Mutation	p.A142T	2
TARS2	LIHC	chr1	150479399	150479399	C	-	Frame_Shift_Del	p.G672fs	2
TARS2	UCEC	chr1	150460483	150460483	T	C	Silent	p.D72	2
TARS2	BLCA	chr1	150479406	150479406	G	A	Missense_Mutation	p.E675K	2
TARS2	UCS	chr1	150478148	150478148	C	A	Silent	p.R659R	2
TARS2	LIHC	chr1	150471707	150471707	C	G	Missense_Mutation		2
TARS2	SKCM	chr1	150464927	150464927	C	T	Missense_Mutation	p.R246W	2
TARS2	UCEC	chr1	150461542	150461542	C	T	Silent	p.F122	2
TARS2	BLCA	chr1	150479442	150479442	G	A	Missense_Mutation	p.D687N	2
TARS2	STAD	chr1	150477184	150477184	C	T	Silent	p.L599L	2
TARS2	SKCM	chr1	150463097	150463097	C	T	Silent	p.T136T	2
TARS2	BLCA	chr1	150479498	150479498	G	T	Missense_Mutation		2
TARS2	CESC	chr1	150460453	150460453	G	G	Missense_Mutation		2
TARS2	BLCA	chr1	150460385	150460385	G	A	Missense_Mutation	p.E40K	2
TARS2	STAD	chr1	150463135	150463135	C	A	Missense_Mutation	p.A149D	2
TARS2	LIHC	chr1	150471707	150471707	C	G	Missense_Mutation	p.L519V	2
TARS2	HNSC	chr1	150460440	150460440	C	G	Missense_Mutation		1
TARS2	LIHC	chr1	150463106	150463106	G	-	Frame_Shift_Del	p.L139fs	1
TARS2	STAD	chr1	150479415	150479415	A	G	Missense_Mutation	p.K678E	1
TARS2	BLCA	chr1	150476843	150476843	G	A	Silent		1
TARS2	CESC	chr1	150464809	150464809	C	T	RNA	NULL	1
TARS2	KIRP	chr1	150469323	150469323	G	T	Missense_Mutation		1
TARS2	SKCM	chr1	150463976	150463976	C	T	Nonsense_Mutation	p.Q207*	1
TARS2	COAD	chr1	150463885	150463885	A	C	Silent	p.S176S	1
TARS2	BLCA	chr1	150461520	150461520	C	G	Missense_Mutation		1
TARS2	HNSC	chr1	150460440	150460440	C	G	Missense_Mutation	p.P58R	1
TARS2	LIHC	chr1	150464917	150464917	C	-	Frame_Shift_Del	p.G242fs	1
TARS2	STAD	chr1	150476863	150476863	T	A	Missense_Mutation		1
TARS2	BLCA	chr1	150463906	150463906	G	A	Missense_Mutation		1
TARS2	CESC	chr1	150477120	150477120	C	T	Silent	p.A577	1
TARS2	LGG	chr1	150469060	150469060	T	C	Missense_Mutation	p.W293R	1
TARS2	LUAD	chr1	150471511	150471511	G	T	Splice_Site		1
TARS2	PAAD	chr1	150470161	150470161	C	T	Silent	p.D392D	1
TARS2	SKCM	chr1	150469286	150469286	G	A	Splice_Site	p.E308_splice	1
TARS2	SARC	chr1	150463910	150463910	T	A	Missense_Mutation		1
TARS2	BLCA	chr1	150463184	150463184	C	A	Missense_Mutation		1
TARS2	LIHC	chr1	150471453	150471453	G	A	Silent	p.L494L	1
TARS2	HNSC	chr1	150463905	150463905	G	A	Missense_Mutation	p.R183Q	1
TARS2	LIHC	chr1	150460439	150460439	C	-	Frame_Shift_Del	p.P58fs	1
TARS2	TGCT	chr1	150470061	150470061	C	T	Missense_Mutation		1
TARS2	CESC	chr1	150477452	150477452	G	C	Missense_Mutation	p.E631Q	1
TARS2	LGG	chr1	150469060	150469060	T	C	Missense_Mutation		1
TARS2	LUAD	chr1	150471498	150471498	C	A	Missense_Mutation	p.D509E	1
TARS2	PRAD	chr1	150464910	150464910	G	A	Missense_Mutation	p.C240Y	1
TARS2	SKCM	chr1	150459936	150459936	T	G	Missense_Mutation	p.Y4D	1
TARS2	DLBC	chr1	150470182	150470182	A	G	Silent	p.T399T	1
TARS2	SKCM	chr1	150469286	150469286	G	A	Missense_Mutation	p.E308K	1
TARS2	BLCA	chr1	150479406	150479406	G	A	Missense_Mutation		1
TARS2	HNSC	chr1	150460453	150460453	G	C	Missense_Mutation	p.K62N	1
TARS2	LIHC	chr1	150477177	150477177	G	-	Frame_Shift_Del	p.L596fs	1
TARS2	UCEC	chr1	150477121	150477121	C	A	Missense_Mutation	p.L578M	1
TARS2	COAD	chr1	150460397	150460397	G	A	Missense_Mutation	p.A44T	1
TARS2	LIHC	chr1	150461631	150461631	A	G	Missense_Mutation		1
TARS2	LUAD	chr1	150464139	150464139	G	A	Splice_Site	p.G232_splice	1
TARS2	SKCM	chr1	150471388	150471388	C	T	Nonsense_Mutation	p.Q473*	1
TARS2	BLCA	chr1	150479442	150479442	G	A	Missense_Mutation		1
TARS2	LUAD	chr1	150477145	150477145	C	T	Nonsense_Mutation	p.R586*	1
TARS2	COAD	chr1	150461540	150461540	T	G	Missense_Mutation	p.F122V	1
TARS2	LUSC	chr1	150477408	150477408	T	C	Missense_Mutation	p.V616A	1
TARS2	SKCM	chr1	150471694	150471694	C	T	Silent	p.V514V	1
TARS2	BLCA	chr1	150479498	150479498	G	T	Missense_Mutation	p.E705D	1
TARS2	BLCA	chr1	150459941	150459941	G	C	Missense_Mutation		1
TARS2	LUAD	chr1	150464139	150464139	G	A	Splice_Site		1
TARS2	SKCM	chr1	150463975	150463975	C	T	Silent	p.R206R	1
TARS2	BLCA	chr1	150461520	150461520	C	G	Missense_Mutation	p.S115C	1
TARS2	COAD	chr1	150463184	150463184	C	T	Silent	p.F165F	1
TARS2	BLCA	chr1	150463906	150463906	G	A	Missense_Mutation	p.D142N	1
TARS2	LUSC	chr1	150478153	150478153	C	T	Silent	p.A660A	1
TARS2	SARC	chr1	150460517	150460517	G	T	Missense_Mutation		1
TARS2	BLCA	chr1	150477198	150477198	C	T	Silent		1
TARS2	SKCM	chr1	150471388	150471388	C	T	Nonsense_Mutation	p.Q473X	1
TARS2	BLCA	chr1	150460385	150460385	G	A	Missense_Mutation		1
TARS2	ESCA	chr1	150463878	150463878	G	T	Missense_Mutation		1
TARS2	KIRC	chr1	150470153	150470157	CAGAG	-	Frame_Shift_Del	p.389_391del	1
TARS2	SKCM	chr1	150463976	150463976	C	T	Nonsense_Mutation	p.Q207X	1
TARS2	UCEC	chr1	150477199	150477199	G	-	Frame_Shift_Del	p.G604fs	1
TARS2	BLCA	chr1	150460379	150460379	C	G	Missense_Mutation	p.L38V	1
TARS2	COAD	chr1	150471104	150471104	G	A	Silent	p.Q455Q	1
TARS2	BLCA	chr1	150471056	150471056	C	T	Silent		1
TARS2	LIHC	chr1	150471706	150471706	C	T	Silent		1
TARS2	LUSC	chr1	150477403	150477403	C	T	Silent	p.F614F	1
TARS2	SARC	chr1	150460400	150460400	G	T	Missense_Mutation		1
TARS2	BLCA	chr1	150463886	150463886	G	C	Missense_Mutation		1
TARS2	CESC	chr1	150469082	150469082	G	T	Missense_Mutation		1
TARS2	ESCA	chr1	150460427	150460427	G	A	Missense_Mutation	p.A54T	1
TARS2	LUAD	chr1	150471495	150471495	G	T	Missense_Mutation	p.W508C	1
TARS2	COAD	chr1	150471113	150471113	C	T	Silent	p.D458D	1
TARS2	BLCA	chr1	150463082	150463082	C	G	Missense_Mutation		1
TARS2	LIHC	chr1	150461700	150461700	C	A	Missense_Mutation		1
TARS2	LUSC	chr1	150477118	150477118	G	T	Missense_Mutation	p.A577S	1
TARS2	SARC	chr1	150471704	150471704	G	T	Missense_Mutation		1
TARS2	STAD	chr1	150476863	150476863	T	A	Missense_Mutation	p.I557N	1
TARS2	BLCA	chr1	150471769	150471769	G	T	Missense_Mutation		1
TARS2	GBM	chr1	150471051	150471051	C	T	Missense_Mutation	p.R438W	1
TARS2	KIRP	chr1	150469382	150469382	A	T	Missense_Mutation	p.R340W	1
TARS2	SKCM	chr1	150471005	150471005	C	T	Silent	p.S422S	1
TARS2	COAD	chr1	150477165	150477165	G	A	Silent	p.V592V	1
TARS2	LUSC	chr1	150469036	150469036	G	A	Missense_Mutation	p.E285K	1
TARS2	SARC	chr1	150477400	150477400	G	T	Silent		1
TARS2	STAD	chr1	150471768	150471768	A	C	Missense_Mutation	p.K539T	1
TARS2	BLCA	chr1	150478109	150478109	G	C	Missense_Mutation		1
TARS2	HNSC	chr1	150478094	150478094	C	A	Missense_Mutation		1
TARS2	LIHC	chr1	150471074	150471074	G	-	Frame_Shift_Del	p.L445fs	1
TARS2	KIRP	chr1	150459921	150459921	A	G	Splice_Site		1
TARS2	SKCM	chr1	150471456	150471456	C	T	Silent	p.S495S	1
TARS2	COAD	chr1	150479450	150479450	T	C	Silent	p.R689R	1
TARS2	SARC	chr1	150477153	150477153	G	T	Silent		1
TARS2	BLCA	chr1	150459893	150459893	C	G	Missense_Mutation		1
TARS2	LIHC	chr1	150470091	150470091	A	G	Missense_Mutation	p.E369G	1
TARS2	LUSC	chr1	150478140	150478140	G	C	Missense_Mutation	p.R656T	1
TARS2	HNSC	chr1	150463905	150463905	G	A	Missense_Mutation		1
TARS2	LIHC	chr1	150476883	150476883	C	-	Frame_Shift_Del	p.P564fs	1
TARS2	STAD	chr1	150471768	150471768	A	C	Splice_Site	p.K539_splice	1
TARS2	KIRP	chr1	150471422	150471422	C	T	Missense_Mutation	p.A484V	1
TARS2	SKCM	chr1	150463975	150463975	C	T	Missense_Mutation	p.P165S	1
TARS2	COAD	chr1	150463139	150463139	T	G	Silent	p.V150V	1
TARS2	SARC	chr1	150477153	150477153	G	T	Silent	p.V588V	1
TARS2	BLCA	chr1	150460379	150460379	C	G	Missense_Mutation		1
TARS2	OV	chr1	150470084	150470084	C	T	Missense_Mutation	p.H367Y	1

Copy number variation (CNV) of TARS2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across TARS2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
96557	N/A	AK092368	EMX1	chr2	73163200	+	TARS2	chr1	150478152	+
96557	SKCM	TCGA-ER-A3EV-06A	PRPF3	chr1	150307712	+	TARS2	chr1	150468958	+
96557	UCEC	TCGA-FI-A3PX	RIT1	chr1	155874101	-	TARS2	chr1	150476810	+
96557	UCEC	TCGA-FI-A3PX-01A	RIT1	chr1	155874102	-	TARS2	chr1	150476811	+
96557	LUAD	TCGA-75-6211-01A	SNX27	chr1	151655921	+	TARS2	chr1	150476811	+
103337	N/A	BI492038	TARS2	chr1	150464286	+	MCL1	chr1	150547035	+
89116	PRAD	TCGA-CH-5750-01A	TARS2	chr1	150463201	+	MRPS21	chr1	150280482	+
99447	STAD	TCGA-FP-8211-01A	TARS2	chr1	150464965	+	QARS	chr3	49133512	-
101527	GBM	TCGA-06-5856-01A	TARS2	chr1	150464965	+	RPRD2	chr1	150443037	+
98448	LUSC	TCGA-85-6560	TARS2	chr1	150464965	+	VPS45	chr1	150116886	+
98448	LUSC	TCGA-85-6560	TARS2	chr1	150469104	+	VPS45	chr1	150116887	+
98448	LUSC	TCGA-85-6560-01A	TARS2	chr1	150464964	+	VPS45	chr1	150116886	+
98448	LUSC	TCGA-85-6560-01A	TARS2	chr1	150464965	+	VPS45	chr1	150116887	+
98448	LUSC	TCGA-85-6560-01A	TARS2	chr1	150469103	+	VPS45	chr1	150116886	+
98448	LUSC	TCGA-85-6560-01A	TARS2	chr1	150469406	+	VPS45	chr1	150113135	+
96558	SKCM	TCGA-EB-A42Z-01A	UCHL5	chr1	192990227	-	TARS2	chr1	150468958	+

Top

Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

Top

Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	TARS2	0.000276020740666173	0.0075
GBM	TARS2	0.00723290428156393	0.19
READ	TARS2	0.0129100865365244	0.32
TGCT	TARS2	0.0273358387826767	0.66
LUSC	TARS2	0.0455839881287377	1
SARC	TARS2	4.838414568321e-05	0.0014

Top

Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	TARS2	0.014283304894578	0.43
THCA	TARS2	0.000165566405459281	0.0055
LGG	TARS2	0.00451226288837239	0.14
PAAD	TARS2	0.00215009073932405	0.069

Top

Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Q9BW92	DB00156	Threonine		Small molecule	Approved\|Nutraceutical
Q9BW92	DB00156	Threonine

Top

Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C4014668	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 21	2	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT