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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: CPEB4 (NCBI Gene ID:80315)

Gene Summary

Gene Summary

Gene Information	Gene Name: CPEB4
	Gene ID: 80315
	Gene Symbol	CPEB4
	Gene ID	80315
	Gene Name	cytoplasmic polyadenylation element binding protein 4
	Synonyms	CPE-BP4\|hCPEB-4
	Cytomap	5q35.2
	Type of Gene	protein-coding
	Description	cytoplasmic polyadenylation element-binding protein 4CPE-binding protein 4
	Modification date	20200313
	UniProtAcc	Q17RY0

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
CPEB4	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'CPEB4[title] AND translation [title] AND human.'

Gene	Title	PMID
CPEB4	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000265085	173359452	173359503	In-frame
ENST00000265085	173370028	173370052	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000265085	173359452	173359503	9500	2662	2712	729	402	419

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q17RY0	402	419	1	729	Chain	ID=PRO_0000269264;Note=Cytoplasmic polyadenylation element-binding protein 4
Q17RY0	402	419	403	419	Alternative sequence	ID=VSP_022041;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:11214970,ECO:0000303\|PubMed:15489334;Dbxref=PMID:11214970,PMID:15489334
Q17RY0	402	419	404	428	Alternative sequence	ID=VSP_022042;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
COAD	CPEB4	2.28126717608637	0.000248014926910401
ESCA	CPEB4	-2.44251769969523	0.0009765625
UCEC	CPEB4	1.78054351869512	0.03125
KIRP	CPEB4	-1.10167529969513	3.94955277442932e-05
STAD	CPEB4	-4.4889556542516	4.02145087718964e-06
LUAD	CPEB4	-1.5302937527361	4.35183654360534e-05
THCA	CPEB4	-2.39199327365457	7.90706167437824e-09

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
LIHC	CPEB4	hsa-miR-181b-5p	81	-0.301961196698039	0.00781851928006114
LUSC	CPEB4	hsa-miR-155-5p	71	-0.301898734177215	0.0070483948510116

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
KICH	CPEB4	1	2	0.0353551246477511	0.181687157894737	0.262838888888889	-0.180475704869211	-0.320058161009544

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
READ	CPEB4	0.062042906	0.001108559
SARC	CPEB4	0.164715534	0.022987325

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with CPEB4 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	CPEB4	ALDH6A1	0.800627286	4.06E-11
CHOL	Cell metabolism gene	CPEB4	LONP2	0.806856539	2.19E-11
CHOL	Cell metabolism gene	CPEB4	ABCA1	0.810108671	1.58E-11
CHOL	IUPHAR	CPEB4	ABCA1	0.810108671	1.58E-11
CHOL	IUPHAR	CPEB4	SLC39A14	0.815702291	8.80E-12
DLBC	Cell metabolism gene	CPEB4	ARFGEF2	0.805822316	4.89E-12
DLBC	Cell metabolism gene	CPEB4	NCOA2	0.826220796	4.82E-13
DLBC	CGC	CPEB4	LATS1	0.804351896	5.72E-12
DLBC	CGC	CPEB4	NCOA2	0.826220796	4.82E-13
DLBC	Epifactor	CPEB4	NCOA2	0.826220796	4.82E-13
DLBC	Epifactor	CPEB4	ZHX1	0.830695983	2.78E-13
DLBC	IUPHAR	CPEB4	HIPK3	0.804021251	5.92E-12
DLBC	IUPHAR	CPEB4	LATS1	0.804351896	5.72E-12
DLBC	IUPHAR	CPEB4	NCOA2	0.826220796	4.82E-13
DLBC	Kinase	CPEB4	HIPK3	0.804021251	5.92E-12
DLBC	Kinase	CPEB4	LATS1	0.804351896	5.72E-12
DLBC	TF	CPEB4	BACH1	0.80769984	4.00E-12
DLBC	TF	CPEB4	NCOA2	0.826220796	4.82E-13
DLBC	TF	CPEB4	ZHX1	0.830695983	2.78E-13
DLBC	TSG	CPEB4	LATS1	0.804351896	5.72E-12
KICH	Cell metabolism gene	CPEB4	ELOVL7	0.810316174	2.28E-22
KICH	Cell metabolism gene	CPEB4	PPARGC1A	0.845677053	5.32E-26
KICH	Epifactor	CPEB4	PPARGC1A	0.845677053	5.32E-26
PAAD	CGC	CPEB4	AFF4	0.808385635	1.62E-43
THYM	Cell metabolism gene	CPEB4	AZIN1	0.80338184	8.66E-29
THYM	Cell metabolism gene	CPEB4	IPMK	0.803740836	7.85E-29
THYM	Cell metabolism gene	CPEB4	PHAX	0.804811968	5.85E-29
THYM	Cell metabolism gene	CPEB4	SEC31A	0.806714725	3.45E-29
THYM	Cell metabolism gene	CPEB4	ACADSB	0.807641676	2.67E-29
THYM	Cell metabolism gene	CPEB4	ITPR3	0.807961333	2.44E-29
THYM	Cell metabolism gene	CPEB4	MGAT5	0.808307996	2.21E-29
THYM	Cell metabolism gene	CPEB4	COL4A3BP	0.809847379	1.43E-29
THYM	Cell metabolism gene	CPEB4	LONP2	0.811800866	8.20E-30
THYM	Cell metabolism gene	CPEB4	AASDHPPT	0.812121493	7.48E-30
THYM	Cell metabolism gene	CPEB4	OAT	0.816741954	1.95E-30
THYM	Cell metabolism gene	CPEB4	CLOCK	0.820053829	7.24E-31
THYM	Cell metabolism gene	CPEB4	EDEM3	0.820356269	6.60E-31
THYM	Cell metabolism gene	CPEB4	UGCG	0.822159128	3.82E-31
THYM	Cell metabolism gene	CPEB4	TNPO1	0.82386065	2.26E-31
THYM	Cell metabolism gene	CPEB4	PAFAH1B2	0.825779395	1.25E-31
THYM	Cell metabolism gene	CPEB4	PIK3CA	0.831878345	1.78E-32
THYM	Cell metabolism gene	CPEB4	PNPLA8	0.831993321	1.72E-32
THYM	Cell metabolism gene	CPEB4	PIK3C2A	0.837333677	2.93E-33
THYM	Cell metabolism gene	CPEB4	PIK3R4	0.838861087	1.74E-33
THYM	Cell metabolism gene	CPEB4	NCOA2	0.845794607	1.55E-34
THYM	Cell metabolism gene	CPEB4	RRM2B	0.877365581	4.43E-40
THYM	Cell metabolism gene	CPEB4	ARFGEF2	0.892905873	2.11E-43
THYM	CGC	CPEB4	TET2	0.802919164	9.82E-29
THYM	CGC	CPEB4	STAG1	0.80424005	6.84E-29
THYM	CGC	CPEB4	BIRC6	0.804841264	5.80E-29
THYM	CGC	CPEB4	NUP98	0.8064685	3.70E-29
THYM	CGC	CPEB4	ATRX	0.824811965	1.69E-31
THYM	CGC	CPEB4	IL6ST	0.825282282	1.46E-31
THYM	CGC	CPEB4	ATR	0.82550814	1.36E-31
THYM	CGC	CPEB4	PAFAH1B2	0.825779395	1.25E-31
THYM	CGC	CPEB4	DICER1	0.827604505	7.02E-32
THYM	CGC	CPEB4	PIK3CA	0.831878345	1.78E-32
THYM	CGC	CPEB4	HIP1	0.835598899	5.23E-33
THYM	CGC	CPEB4	NBN	0.835950917	4.65E-33
THYM	CGC	CPEB4	AKAP9	0.836786453	3.52E-33
THYM	CGC	CPEB4	MAP3K13	0.845038266	2.03E-34
THYM	CGC	CPEB4	NCOA2	0.845794607	1.55E-34
THYM	CGC	CPEB4	MAP3K1	0.852969423	1.11E-35
THYM	CGC	CPEB4	CLIP1	0.86424687	1.31E-37
THYM	CGC	CPEB4	GOLGA5	0.871816056	5.32E-39
THYM	CGC	CPEB4	AFF4	0.887855316	2.86E-42
THYM	Epifactor	CPEB4	TET2	0.802919164	9.82E-29
THYM	Epifactor	CPEB4	TAF2	0.808916521	1.86E-29
THYM	Epifactor	CPEB4	REST	0.80913247	1.75E-29
THYM	Epifactor	CPEB4	ATF2	0.810951539	1.05E-29
THYM	Epifactor	CPEB4	KDM3B	0.814572559	3.68E-30
THYM	Epifactor	CPEB4	PHC3	0.814721154	3.52E-30
THYM	Epifactor	CPEB4	MPHOSPH8	0.819825538	7.75E-31
THYM	Epifactor	CPEB4	CLOCK	0.820053829	7.24E-31
THYM	Epifactor	CPEB4	PHF8	0.820279386	6.76E-31
THYM	Epifactor	CPEB4	ATRX	0.824811965	1.69E-31
THYM	Epifactor	CPEB4	ATR	0.82550814	1.36E-31
THYM	Epifactor	CPEB4	TAF1L	0.826288544	1.06E-31
THYM	Epifactor	CPEB4	TAF1	0.828631174	5.07E-32
THYM	Epifactor	CPEB4	UBE2H	0.830948887	2.41E-32
THYM	Epifactor	CPEB4	RPS6KA5	0.831228084	2.20E-32
THYM	Epifactor	CPEB4	NBN	0.835950917	4.65E-33
THYM	Epifactor	CPEB4	ASH1L	0.839801879	1.26E-33
THYM	Epifactor	CPEB4	JMJD1C	0.844639463	2.34E-34
THYM	Epifactor	CPEB4	NCOA2	0.845794607	1.55E-34
THYM	Epifactor	CPEB4	SHPRH	0.84910588	4.67E-35
THYM	Epifactor	CPEB4	CHD6	0.857163877	2.23E-36
THYM	Epifactor	CPEB4	USP12	0.861293211	4.36E-37
THYM	IUPHAR	CPEB4	NEK4	0.801681317	1.37E-28
THYM	IUPHAR	CPEB4	TWF1	0.803120879	9.29E-29
THYM	IUPHAR	CPEB4	NR2C2	0.803939579	7.43E-29
THYM	IUPHAR	CPEB4	ATP11A	0.804439549	6.48E-29
THYM	IUPHAR	CPEB4	BIRC6	0.804841264	5.80E-29
THYM	IUPHAR	CPEB4	XIAP	0.805487002	4.85E-29
THYM	IUPHAR	CPEB4	MAP4K3	0.805726924	4.54E-29
THYM	IUPHAR	CPEB4	SLC38A7	0.807890507	2.49E-29
THYM	IUPHAR	CPEB4	ITPR3	0.807961333	2.44E-29
THYM	IUPHAR	CPEB4	TRIO	0.808221861	2.27E-29
THYM	IUPHAR	CPEB4	SLC30A4	0.80996945	1.38E-29
THYM	IUPHAR	CPEB4	KDM3B	0.814572559	3.68E-30
THYM	IUPHAR	CPEB4	CLCN3	0.817662114	1.48E-30
THYM	IUPHAR	CPEB4	LMTK2	0.8179183	1.37E-30
THYM	IUPHAR	CPEB4	ATP7A	0.819275879	9.14E-31
THYM	IUPHAR	CPEB4	MAP4K5	0.819481737	8.60E-31
THYM	IUPHAR	CPEB4	CLOCK	0.820053829	7.24E-31
THYM	IUPHAR	CPEB4	PHF8	0.820279386	6.76E-31
THYM	IUPHAR	CPEB4	UGCG	0.822159128	3.82E-31
THYM	IUPHAR	CPEB4	IL6ST	0.825282282	1.46E-31
THYM	IUPHAR	CPEB4	ATR	0.82550814	1.36E-31
THYM	IUPHAR	CPEB4	TAF1L	0.826288544	1.06E-31
THYM	IUPHAR	CPEB4	NIPAL2	0.827048193	8.37E-32
THYM	IUPHAR	CPEB4	TAF1	0.828631174	5.07E-32
THYM	IUPHAR	CPEB4	ADAM17	0.828975982	4.54E-32
THYM	IUPHAR	CPEB4	TAS2R5	0.830902115	2.45E-32
THYM	IUPHAR	CPEB4	RPS6KA5	0.831228084	2.20E-32
THYM	IUPHAR	CPEB4	SLK	0.831679207	1.90E-32
THYM	IUPHAR	CPEB4	PIK3CA	0.831878345	1.78E-32
THYM	IUPHAR	CPEB4	DPP8	0.835727133	5.02E-33
THYM	IUPHAR	CPEB4	PIK3C2A	0.837333677	2.93E-33
THYM	IUPHAR	CPEB4	NEK7	0.837831277	2.47E-33
THYM	IUPHAR	CPEB4	PIK3R4	0.838861087	1.74E-33
THYM	IUPHAR	CPEB4	TRPM7	0.839655469	1.33E-33
THYM	IUPHAR	CPEB4	ASH1L	0.839801879	1.26E-33
THYM	IUPHAR	CPEB4	TNKS	0.843685615	3.27E-34
THYM	IUPHAR	CPEB4	SLC30A6	0.844140701	2.79E-34
THYM	IUPHAR	CPEB4	JMJD1C	0.844639463	2.34E-34
THYM	IUPHAR	CPEB4	MAP3K13	0.845038266	2.03E-34
THYM	IUPHAR	CPEB4	NCOA2	0.845794607	1.55E-34
THYM	IUPHAR	CPEB4	PREPL	0.848251851	6.38E-35
THYM	IUPHAR	CPEB4	MAP3K1	0.852969423	1.11E-35
THYM	IUPHAR	CPEB4	HIPK3	0.858191825	1.49E-36
THYM	IUPHAR	CPEB4	RRM2B	0.877365581	4.43E-40
THYM	IUPHAR	CPEB4	PDPK1	0.880174891	1.20E-40
THYM	IUPHAR	CPEB4	SLC30A5	0.882035245	4.99E-41
THYM	Kinase	CPEB4	NEK4	0.801681317	1.37E-28
THYM	Kinase	CPEB4	MAP4K3	0.805726924	4.54E-29
THYM	Kinase	CPEB4	TRIO	0.808221861	2.27E-29
THYM	Kinase	CPEB4	COL4A3BP	0.809847379	1.43E-29
THYM	Kinase	CPEB4	LMTK2	0.8179183	1.37E-30
THYM	Kinase	CPEB4	MAP4K5	0.819481737	8.60E-31
THYM	Kinase	CPEB4	ATR	0.82550814	1.36E-31
THYM	Kinase	CPEB4	TAF1L	0.826288544	1.06E-31
THYM	Kinase	CPEB4	TAF1	0.828631174	5.07E-32
THYM	Kinase	CPEB4	RPS6KA5	0.831228084	2.20E-32
THYM	Kinase	CPEB4	SLK	0.831679207	1.90E-32
THYM	Kinase	CPEB4	NEK7	0.837831277	2.47E-33
THYM	Kinase	CPEB4	PIK3R4	0.838861087	1.74E-33
THYM	Kinase	CPEB4	TRPM7	0.839655469	1.33E-33
THYM	Kinase	CPEB4	MAP3K13	0.845038266	2.03E-34
THYM	Kinase	CPEB4	MAP3K1	0.852969423	1.11E-35
THYM	Kinase	CPEB4	HIPK3	0.858191825	1.49E-36
THYM	Kinase	CPEB4	PDPK1	0.880174891	1.20E-40
THYM	TF	CPEB4	RBAK	0.800753801	1.76E-28
THYM	TF	CPEB4	ZXDB	0.801248734	1.54E-28
THYM	TF	CPEB4	TET2	0.802919164	9.82E-29
THYM	TF	CPEB4	NR2C2	0.803939579	7.43E-29
THYM	TF	CPEB4	ZNF761	0.804868634	5.76E-29
THYM	TF	CPEB4	SKIL	0.804891366	5.72E-29
THYM	TF	CPEB4	JRKL	0.806627339	3.54E-29
THYM	TF	CPEB4	ZNF484	0.807081846	3.12E-29
THYM	TF	CPEB4	ZNF281	0.809090261	1.77E-29
THYM	TF	CPEB4	REST	0.80913247	1.75E-29
THYM	TF	CPEB4	ATF2	0.810951539	1.05E-29
THYM	TF	CPEB4	ZFX	0.811510174	8.91E-30
THYM	TF	CPEB4	ELK3	0.812553233	6.61E-30
THYM	TF	CPEB4	ZNF678	0.81289457	5.99E-30
THYM	TF	CPEB4	ZNF426	0.814513019	3.74E-30
THYM	TF	CPEB4	CLOCK	0.820053829	7.24E-31
THYM	TF	CPEB4	ZNF623	0.823341028	2.66E-31
THYM	TF	CPEB4	ZNF354B	0.823572205	2.47E-31
THYM	TF	CPEB4	ZBTB38	0.829939624	3.34E-32
THYM	TF	CPEB4	RREB1	0.830714569	2.60E-32
THYM	TF	CPEB4	ZNF41	0.833618379	1.01E-32
THYM	TF	CPEB4	EEA1	0.837083911	3.18E-33
THYM	TF	CPEB4	ASH1L	0.839801879	1.26E-33
THYM	TF	CPEB4	TMF1	0.840995011	8.38E-34
THYM	TF	CPEB4	ZNF611	0.841346897	7.41E-34
THYM	TF	CPEB4	ZNF432	0.84226633	5.38E-34
THYM	TF	CPEB4	NCOA2	0.845794607	1.55E-34
THYM	TF	CPEB4	ZBTB41	0.846311954	1.29E-34
THYM	TF	CPEB4	ZNF791	0.848602698	5.61E-35
THYM	TF	CPEB4	HIVEP1	0.848831385	5.16E-35
THYM	TF	CPEB4	BBX	0.853623644	8.68E-36
THYM	TF	CPEB4	ETV3	0.855378731	4.45E-36
THYM	TSG	CPEB4	TANK	0.800077073	2.12E-28
THYM	TSG	CPEB4	TET2	0.802919164	9.82E-29
THYM	TSG	CPEB4	NR2C2	0.803939579	7.43E-29
THYM	TSG	CPEB4	SKIL	0.804891366	5.72E-29
THYM	TSG	CPEB4	NUP98	0.8064685	3.70E-29
THYM	TSG	CPEB4	FAM172A	0.812883333	6.01E-30
THYM	TSG	CPEB4	KDM3B	0.814572559	3.68E-30
THYM	TSG	CPEB4	PHC3	0.814721154	3.52E-30
THYM	TSG	CPEB4	KRIT1	0.815525707	2.78E-30
THYM	TSG	CPEB4	ATR	0.82550814	1.36E-31
THYM	TSG	CPEB4	DICER1	0.827604505	7.02E-32
THYM	TSG	CPEB4	NBN	0.835950917	4.65E-33
THYM	TSG	CPEB4	HIVEP1	0.848831385	5.16E-35
THYM	TSG	CPEB4	SHPRH	0.84910588	4.67E-35
THYM	TSG	CPEB4	USP12	0.861293211	4.36E-37
UCS	Cell metabolism gene	CPEB4	AZIN1	0.80338184	8.66E-29
UCS	Cell metabolism gene	CPEB4	IPMK	0.803740836	7.85E-29
UCS	Cell metabolism gene	CPEB4	PHAX	0.804811968	5.85E-29
UCS	Cell metabolism gene	CPEB4	SEC31A	0.806714725	3.45E-29
UCS	Cell metabolism gene	CPEB4	ACADSB	0.807641676	2.67E-29
UCS	Cell metabolism gene	CPEB4	ITPR3	0.807961333	2.44E-29
UCS	Cell metabolism gene	CPEB4	MGAT5	0.808307996	2.21E-29
UCS	Cell metabolism gene	CPEB4	COL4A3BP	0.809847379	1.43E-29
UCS	Cell metabolism gene	CPEB4	LONP2	0.811800866	8.20E-30
UCS	Cell metabolism gene	CPEB4	AASDHPPT	0.812121493	7.48E-30
UCS	Cell metabolism gene	CPEB4	OAT	0.816741954	1.95E-30
UCS	Cell metabolism gene	CPEB4	CLOCK	0.820053829	7.24E-31
UCS	Cell metabolism gene	CPEB4	EDEM3	0.820356269	6.60E-31
UCS	Cell metabolism gene	CPEB4	UGCG	0.822159128	3.82E-31
UCS	Cell metabolism gene	CPEB4	TNPO1	0.82386065	2.26E-31
UCS	Cell metabolism gene	CPEB4	PAFAH1B2	0.825779395	1.25E-31
UCS	Cell metabolism gene	CPEB4	PIK3CA	0.831878345	1.78E-32
UCS	Cell metabolism gene	CPEB4	PNPLA8	0.831993321	1.72E-32
UCS	Cell metabolism gene	CPEB4	PIK3C2A	0.837333677	2.93E-33
UCS	Cell metabolism gene	CPEB4	PIK3R4	0.838861087	1.74E-33
UCS	Cell metabolism gene	CPEB4	NCOA2	0.845794607	1.55E-34
UCS	Cell metabolism gene	CPEB4	RRM2B	0.877365581	4.43E-40
UCS	Cell metabolism gene	CPEB4	ARFGEF2	0.892905873	2.11E-43
UCS	CGC	CPEB4	TET2	0.802919164	9.82E-29
UCS	CGC	CPEB4	STAG1	0.80424005	6.84E-29
UCS	CGC	CPEB4	BIRC6	0.804841264	5.80E-29
UCS	CGC	CPEB4	NUP98	0.8064685	3.70E-29
UCS	CGC	CPEB4	ATRX	0.824811965	1.69E-31
UCS	CGC	CPEB4	IL6ST	0.825282282	1.46E-31
UCS	CGC	CPEB4	ATR	0.82550814	1.36E-31
UCS	CGC	CPEB4	PAFAH1B2	0.825779395	1.25E-31
UCS	CGC	CPEB4	DICER1	0.827604505	7.02E-32
UCS	CGC	CPEB4	PIK3CA	0.831878345	1.78E-32
UCS	CGC	CPEB4	HIP1	0.835598899	5.23E-33
UCS	CGC	CPEB4	NBN	0.835950917	4.65E-33
UCS	CGC	CPEB4	AKAP9	0.836786453	3.52E-33
UCS	CGC	CPEB4	MAP3K13	0.845038266	2.03E-34
UCS	CGC	CPEB4	NCOA2	0.845794607	1.55E-34
UCS	CGC	CPEB4	MAP3K1	0.852969423	1.11E-35
UCS	CGC	CPEB4	CLIP1	0.86424687	1.31E-37
UCS	CGC	CPEB4	GOLGA5	0.871816056	5.32E-39
UCS	CGC	CPEB4	AFF4	0.887855316	2.86E-42
UCS	Epifactor	CPEB4	TET2	0.802919164	9.82E-29
UCS	Epifactor	CPEB4	TAF2	0.808916521	1.86E-29
UCS	Epifactor	CPEB4	REST	0.80913247	1.75E-29
UCS	Epifactor	CPEB4	ATF2	0.810951539	1.05E-29
UCS	Epifactor	CPEB4	KDM3B	0.814572559	3.68E-30
UCS	Epifactor	CPEB4	PHC3	0.814721154	3.52E-30
UCS	Epifactor	CPEB4	MPHOSPH8	0.819825538	7.75E-31
UCS	Epifactor	CPEB4	CLOCK	0.820053829	7.24E-31
UCS	Epifactor	CPEB4	PHF8	0.820279386	6.76E-31
UCS	Epifactor	CPEB4	ATRX	0.824811965	1.69E-31
UCS	Epifactor	CPEB4	ATR	0.82550814	1.36E-31
UCS	Epifactor	CPEB4	TAF1L	0.826288544	1.06E-31
UCS	Epifactor	CPEB4	TAF1	0.828631174	5.07E-32
UCS	Epifactor	CPEB4	UBE2H	0.830948887	2.41E-32
UCS	Epifactor	CPEB4	RPS6KA5	0.831228084	2.20E-32
UCS	Epifactor	CPEB4	NBN	0.835950917	4.65E-33
UCS	Epifactor	CPEB4	ASH1L	0.839801879	1.26E-33
UCS	Epifactor	CPEB4	JMJD1C	0.844639463	2.34E-34
UCS	Epifactor	CPEB4	NCOA2	0.845794607	1.55E-34
UCS	Epifactor	CPEB4	SHPRH	0.84910588	4.67E-35
UCS	Epifactor	CPEB4	CHD6	0.857163877	2.23E-36
UCS	Epifactor	CPEB4	USP12	0.861293211	4.36E-37
UCS	IUPHAR	CPEB4	NEK4	0.801681317	1.37E-28
UCS	IUPHAR	CPEB4	TWF1	0.803120879	9.29E-29
UCS	IUPHAR	CPEB4	NR2C2	0.803939579	7.43E-29
UCS	IUPHAR	CPEB4	ATP11A	0.804439549	6.48E-29
UCS	IUPHAR	CPEB4	BIRC6	0.804841264	5.80E-29
UCS	IUPHAR	CPEB4	XIAP	0.805487002	4.85E-29
UCS	IUPHAR	CPEB4	MAP4K3	0.805726924	4.54E-29
UCS	IUPHAR	CPEB4	SLC38A7	0.807890507	2.49E-29
UCS	IUPHAR	CPEB4	ITPR3	0.807961333	2.44E-29
UCS	IUPHAR	CPEB4	TRIO	0.808221861	2.27E-29
UCS	IUPHAR	CPEB4	SLC30A4	0.80996945	1.38E-29
UCS	IUPHAR	CPEB4	KDM3B	0.814572559	3.68E-30
UCS	IUPHAR	CPEB4	CLCN3	0.817662114	1.48E-30
UCS	IUPHAR	CPEB4	LMTK2	0.8179183	1.37E-30
UCS	IUPHAR	CPEB4	ATP7A	0.819275879	9.14E-31
UCS	IUPHAR	CPEB4	MAP4K5	0.819481737	8.60E-31
UCS	IUPHAR	CPEB4	CLOCK	0.820053829	7.24E-31
UCS	IUPHAR	CPEB4	PHF8	0.820279386	6.76E-31
UCS	IUPHAR	CPEB4	UGCG	0.822159128	3.82E-31
UCS	IUPHAR	CPEB4	IL6ST	0.825282282	1.46E-31
UCS	IUPHAR	CPEB4	ATR	0.82550814	1.36E-31
UCS	IUPHAR	CPEB4	TAF1L	0.826288544	1.06E-31
UCS	IUPHAR	CPEB4	NIPAL2	0.827048193	8.37E-32
UCS	IUPHAR	CPEB4	TAF1	0.828631174	5.07E-32
UCS	IUPHAR	CPEB4	ADAM17	0.828975982	4.54E-32
UCS	IUPHAR	CPEB4	TAS2R5	0.830902115	2.45E-32
UCS	IUPHAR	CPEB4	RPS6KA5	0.831228084	2.20E-32
UCS	IUPHAR	CPEB4	SLK	0.831679207	1.90E-32
UCS	IUPHAR	CPEB4	PIK3CA	0.831878345	1.78E-32
UCS	IUPHAR	CPEB4	DPP8	0.835727133	5.02E-33
UCS	IUPHAR	CPEB4	PIK3C2A	0.837333677	2.93E-33
UCS	IUPHAR	CPEB4	NEK7	0.837831277	2.47E-33
UCS	IUPHAR	CPEB4	PIK3R4	0.838861087	1.74E-33
UCS	IUPHAR	CPEB4	TRPM7	0.839655469	1.33E-33
UCS	IUPHAR	CPEB4	ASH1L	0.839801879	1.26E-33
UCS	IUPHAR	CPEB4	TNKS	0.843685615	3.27E-34
UCS	IUPHAR	CPEB4	SLC30A6	0.844140701	2.79E-34
UCS	IUPHAR	CPEB4	JMJD1C	0.844639463	2.34E-34
UCS	IUPHAR	CPEB4	MAP3K13	0.845038266	2.03E-34
UCS	IUPHAR	CPEB4	NCOA2	0.845794607	1.55E-34
UCS	IUPHAR	CPEB4	PREPL	0.848251851	6.38E-35
UCS	IUPHAR	CPEB4	MAP3K1	0.852969423	1.11E-35
UCS	IUPHAR	CPEB4	HIPK3	0.858191825	1.49E-36
UCS	IUPHAR	CPEB4	RRM2B	0.877365581	4.43E-40
UCS	IUPHAR	CPEB4	PDPK1	0.880174891	1.20E-40
UCS	IUPHAR	CPEB4	SLC30A5	0.882035245	4.99E-41
UCS	Kinase	CPEB4	NEK4	0.801681317	1.37E-28
UCS	Kinase	CPEB4	MAP4K3	0.805726924	4.54E-29
UCS	Kinase	CPEB4	TRIO	0.808221861	2.27E-29
UCS	Kinase	CPEB4	COL4A3BP	0.809847379	1.43E-29
UCS	Kinase	CPEB4	LMTK2	0.8179183	1.37E-30
UCS	Kinase	CPEB4	MAP4K5	0.819481737	8.60E-31
UCS	Kinase	CPEB4	ATR	0.82550814	1.36E-31
UCS	Kinase	CPEB4	TAF1L	0.826288544	1.06E-31
UCS	Kinase	CPEB4	TAF1	0.828631174	5.07E-32
UCS	Kinase	CPEB4	RPS6KA5	0.831228084	2.20E-32
UCS	Kinase	CPEB4	SLK	0.831679207	1.90E-32
UCS	Kinase	CPEB4	NEK7	0.837831277	2.47E-33
UCS	Kinase	CPEB4	PIK3R4	0.838861087	1.74E-33
UCS	Kinase	CPEB4	TRPM7	0.839655469	1.33E-33
UCS	Kinase	CPEB4	MAP3K13	0.845038266	2.03E-34
UCS	Kinase	CPEB4	MAP3K1	0.852969423	1.11E-35
UCS	Kinase	CPEB4	HIPK3	0.858191825	1.49E-36
UCS	Kinase	CPEB4	PDPK1	0.880174891	1.20E-40
UCS	TF	CPEB4	RBAK	0.800753801	1.76E-28
UCS	TF	CPEB4	ZXDB	0.801248734	1.54E-28
UCS	TF	CPEB4	TET2	0.802919164	9.82E-29
UCS	TF	CPEB4	NR2C2	0.803939579	7.43E-29
UCS	TF	CPEB4	ZNF761	0.804868634	5.76E-29
UCS	TF	CPEB4	SKIL	0.804891366	5.72E-29
UCS	TF	CPEB4	JRKL	0.806627339	3.54E-29
UCS	TF	CPEB4	ZNF484	0.807081846	3.12E-29
UCS	TF	CPEB4	ZNF281	0.809090261	1.77E-29
UCS	TF	CPEB4	REST	0.80913247	1.75E-29
UCS	TF	CPEB4	ATF2	0.810951539	1.05E-29
UCS	TF	CPEB4	ZFX	0.811510174	8.91E-30
UCS	TF	CPEB4	ELK3	0.812553233	6.61E-30
UCS	TF	CPEB4	ZNF678	0.81289457	5.99E-30
UCS	TF	CPEB4	ZNF426	0.814513019	3.74E-30
UCS	TF	CPEB4	CLOCK	0.820053829	7.24E-31
UCS	TF	CPEB4	ZNF623	0.823341028	2.66E-31
UCS	TF	CPEB4	ZNF354B	0.823572205	2.47E-31
UCS	TF	CPEB4	ZBTB38	0.829939624	3.34E-32
UCS	TF	CPEB4	RREB1	0.830714569	2.60E-32
UCS	TF	CPEB4	ZNF41	0.833618379	1.01E-32
UCS	TF	CPEB4	EEA1	0.837083911	3.18E-33
UCS	TF	CPEB4	ASH1L	0.839801879	1.26E-33
UCS	TF	CPEB4	TMF1	0.840995011	8.38E-34
UCS	TF	CPEB4	ZNF611	0.841346897	7.41E-34
UCS	TF	CPEB4	ZNF432	0.84226633	5.38E-34
UCS	TF	CPEB4	NCOA2	0.845794607	1.55E-34
UCS	TF	CPEB4	ZBTB41	0.846311954	1.29E-34
UCS	TF	CPEB4	ZNF791	0.848602698	5.61E-35
UCS	TF	CPEB4	HIVEP1	0.848831385	5.16E-35
UCS	TF	CPEB4	BBX	0.853623644	8.68E-36
UCS	TF	CPEB4	ETV3	0.855378731	4.45E-36
UCS	TSG	CPEB4	TANK	0.800077073	2.12E-28
UCS	TSG	CPEB4	TET2	0.802919164	9.82E-29
UCS	TSG	CPEB4	NR2C2	0.803939579	7.43E-29
UCS	TSG	CPEB4	SKIL	0.804891366	5.72E-29
UCS	TSG	CPEB4	NUP98	0.8064685	3.70E-29
UCS	TSG	CPEB4	FAM172A	0.812883333	6.01E-30
UCS	TSG	CPEB4	KDM3B	0.814572559	3.68E-30
UCS	TSG	CPEB4	PHC3	0.814721154	3.52E-30
UCS	TSG	CPEB4	KRIT1	0.815525707	2.78E-30
UCS	TSG	CPEB4	ATR	0.82550814	1.36E-31
UCS	TSG	CPEB4	DICER1	0.827604505	7.02E-32
UCS	TSG	CPEB4	NBN	0.835950917	4.65E-33
UCS	TSG	CPEB4	HIVEP1	0.848831385	5.16E-35
UCS	TSG	CPEB4	SHPRH	0.84910588	4.67E-35
UCS	TSG	CPEB4	USP12	0.861293211	4.36E-37
UVM	Cell metabolism gene	CPEB4	NUDT12	0.800187648	5.37E-19
UVM	Cell metabolism gene	CPEB4	PNPLA8	0.800376352	5.20E-19
UVM	Cell metabolism gene	CPEB4	PI4K2B	0.807977438	1.34E-19
UVM	Cell metabolism gene	CPEB4	UGGT2	0.809815847	9.52E-20
UVM	Cell metabolism gene	CPEB4	SRP19	0.810413742	8.53E-20
UVM	Cell metabolism gene	CPEB4	SAR1B	0.810669368	8.13E-20
UVM	Cell metabolism gene	CPEB4	PIK3C2A	0.812027958	6.31E-20
UVM	Cell metabolism gene	CPEB4	PSME4	0.812583323	5.69E-20
UVM	Cell metabolism gene	CPEB4	PANK3	0.821115672	1.10E-20
UVM	Cell metabolism gene	CPEB4	ACADSB	0.824452847	5.64E-21
UVM	Cell metabolism gene	CPEB4	MAN2A1	0.832373641	1.09E-21
UVM	Cell metabolism gene	CPEB4	RRM2B	0.834448001	7.01E-22
UVM	Cell metabolism gene	CPEB4	PRKAA1	0.83461272	6.77E-22
UVM	Cell metabolism gene	CPEB4	CLOCK	0.851524793	1.41E-23
UVM	Cell metabolism gene	CPEB4	PHAX	0.852386316	1.15E-23
UVM	Cell metabolism gene	CPEB4	COL4A3BP	0.852923013	1.01E-23
UVM	Cell metabolism gene	CPEB4	TNPO1	0.866476048	3.03E-25
UVM	CGC	CPEB4	DDX5	0.816265511	2.83E-20
UVM	CGC	CPEB4	CLIP1	0.833525754	8.55E-22
UVM	CGC	CPEB4	KIF5B	0.834475892	6.97E-22
UVM	CGC	CPEB4	AFF4	0.839509267	2.31E-22
UVM	CGC	CPEB4	PWWP2A	0.867799397	2.11E-25
UVM	Epifactor	CPEB4	JMJD1C	0.800121398	5.43E-19
UVM	Epifactor	CPEB4	TDG	0.803629149	2.93E-19
UVM	Epifactor	CPEB4	SMARCA5	0.807857261	1.36E-19
UVM	Epifactor	CPEB4	BAZ2B	0.808494072	1.21E-19
UVM	Epifactor	CPEB4	SMEK2	0.808696947	1.17E-19
UVM	Epifactor	CPEB4	SMEK1	0.808746681	1.16E-19
UVM	Epifactor	CPEB4	PRKAA1	0.83461272	6.77E-22
UVM	Epifactor	CPEB4	TLK1	0.836877014	4.14E-22
UVM	Epifactor	CPEB4	USP15	0.837602607	3.53E-22
UVM	Epifactor	CPEB4	CLOCK	0.851524793	1.41E-23
UVM	IUPHAR	CPEB4	JMJD1C	0.800121398	5.43E-19
UVM	IUPHAR	CPEB4	CDC42BPA	0.802122613	3.82E-19
UVM	IUPHAR	CPEB4	MAP4K3	0.802943276	3.31E-19
UVM	IUPHAR	CPEB4	TMEM165	0.805095912	2.25E-19
UVM	IUPHAR	CPEB4	PI4K2B	0.807977438	1.34E-19
UVM	IUPHAR	CPEB4	USP14	0.808475314	1.22E-19
UVM	IUPHAR	CPEB4	BAZ2B	0.808494072	1.21E-19
UVM	IUPHAR	CPEB4	TNKS2	0.811198223	7.37E-20
UVM	IUPHAR	CPEB4	PIK3C2A	0.812027958	6.31E-20
UVM	IUPHAR	CPEB4	SLC37A3	0.817512424	2.22E-20
UVM	IUPHAR	CPEB4	PKN2	0.817810668	2.10E-20
UVM	IUPHAR	CPEB4	SLC30A7	0.820826733	1.16E-20
UVM	IUPHAR	CPEB4	MAPK6	0.826039195	4.09E-21
UVM	IUPHAR	CPEB4	RRM2B	0.834448001	7.01E-22
UVM	IUPHAR	CPEB4	PRKAA1	0.83461272	6.77E-22
UVM	IUPHAR	CPEB4	TLK1	0.836877014	4.14E-22
UVM	IUPHAR	CPEB4	MAP3K2	0.840215122	1.98E-22
UVM	IUPHAR	CPEB4	SLC38A2	0.843595571	9.18E-23
UVM	IUPHAR	CPEB4	TBK1	0.847052725	4.11E-23
UVM	IUPHAR	CPEB4	CLOCK	0.851524793	1.41E-23
UVM	IUPHAR	CPEB4	XIAP	0.860321962	1.56E-24
UVM	IUPHAR	CPEB4	CSNK1A1	0.861106437	1.27E-24
UVM	Kinase	CPEB4	CDC42BPA	0.802122613	3.82E-19
UVM	Kinase	CPEB4	MAP4K3	0.802943276	3.31E-19
UVM	Kinase	CPEB4	PKN2	0.817810668	2.10E-20
UVM	Kinase	CPEB4	MAPK6	0.826039195	4.09E-21
UVM	Kinase	CPEB4	PRKAA1	0.83461272	6.77E-22
UVM	Kinase	CPEB4	TLK1	0.836877014	4.14E-22
UVM	Kinase	CPEB4	MAP3K2	0.840215122	1.98E-22
UVM	Kinase	CPEB4	TBK1	0.847052725	4.11E-23
UVM	Kinase	CPEB4	COL4A3BP	0.852923013	1.01E-23
UVM	Kinase	CPEB4	CSNK1A1	0.861106437	1.27E-24
UVM	TF	CPEB4	IKZF5	0.800652335	4.95E-19
UVM	TF	CPEB4	GPBP1	0.801590284	4.20E-19
UVM	TF	CPEB4	ZNF25	0.801684234	4.13E-19
UVM	TF	CPEB4	ZNF326	0.80487977	2.34E-19
UVM	TF	CPEB4	BAZ2B	0.808494072	1.21E-19
UVM	TF	CPEB4	ZNF267	0.809851498	9.46E-20
UVM	TF	CPEB4	CEBPG	0.816652107	2.63E-20
UVM	TF	CPEB4	ZNF800	0.827311927	3.15E-21
UVM	TF	CPEB4	CLOCK	0.851524793	1.41E-23
UVM	TSG	CPEB4	INTS6	0.802068498	3.86E-19
UVM	TSG	CPEB4	RBBP8	0.803677517	2.90E-19
UVM	TSG	CPEB4	CCAR1	0.809953806	9.28E-20
UVM	TSG	CPEB4	PRKAA1	0.83461272	6.77E-22
UVM	TSG	CPEB4	GORAB	0.843606678	9.16E-23
UVM	TSG	CPEB4	CSNK1A1	0.861106437	1.27E-24

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	CPEB4	PDE4B	1.59520300471543	0.000110303983092308
LUAD	CPEB4	PDE4B	-1.74350533934375	0.000214884962722287
BRCA	CPEB4	ST8SIA4	2.03082768341769	0.000437937199900159
KICH	CPEB4	FMR1	1.78310178813069	0.00102710723876953
KICH	CPEB4	PDE4B	1.72045467167607	0.00341922044754028
KIRP	CPEB4	CPEB1	2.39393200480884	0.00361521635204554
KIRP	CPEB4	FMR1	-1.94284822624948	0.0099095250479877
ESCA	CPEB4	LSM14A	-3.69586672689126	0.013671875
HNSC	CPEB4	LSM14A	-1.43426729122269	0.0256568653412614
COAD	CPEB4	LSM14A	-1.67535009491501	0.0291509032249451
READ	CPEB4	AURKA	2.44185876815714	0.03125
READ	CPEB4	CDK1	1.89004239599197	0.03125
READ	CPEB4	PLK1	2.49229699621777	0.03125
BRCA	CPEB4	FMR1	-2.74053611255086	0.0481383834499222
KIRC	CPEB4	FMR1	-2.35406916543664	1.12145348829767e-07
LIHC	CPEB4	CCNB2	-2.52392868377072	1.26395969954206e-09
HNSC	CPEB4	FMR1	-2.72606987034586	1.37760207508109e-06
KIRP	CPEB4	ST8SIA4	-2.90729760418628	1.42422504723072e-05
LUSC	CPEB4	ST8SIA4	-2.75304157636862	1.45947399043856e-08
KIRP	CPEB4	AURKA	-1.39611353637217	2.00234353542328e-08
KIRP	CPEB4	CCNB2	-1.18545366541394	2.00234353542328e-08
COAD	CPEB4	PLK1	1.87321844191486	2.08616256713867e-07
LIHC	CPEB4	PDE4B	2.10523484078365	2.25731418060625e-05
PRAD	CPEB4	CCNB2	-1.21482461847798	2.36390621045854e-07
KIRC	CPEB4	PLK1	-1.10261987714157	2.37769366427877e-11
COAD	CPEB4	CCNB2	1.17232391077129	2.69412994384766e-05
BRCA	CPEB4	PDE4B	-1.21818489971218	2.74656511350046e-05
KIRP	CPEB4	PLK1	-1.20762698709131	3.25962901115418e-08
KICH	CPEB4	AURKA	-5.44989541314857	5.96046447753906e-08
LIHC	CPEB4	PLK1	-2.42274928488654	8.27893173553169e-10
LIHC	CPEB4	CDK1	-2.27509761133223	8.79719397863617e-10
COAD	CPEB4	AURKA	2.45048892666079	8.94069671630861e-08
KIRC	CPEB4	CCNB2	-1.24795297754405	9.04004890862992e-12

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with CPEB4

NDST1, UBE3C, SAV1, BMI1, FBXO7, EGLN3, KIAA1429, N, ALG13, ANKRD17, ATXN2, CELF1, CNOT2, CNOT7, RQCD1, AGO1, AGO2, AGO3, AP2A1, ARHGAP32, CC2D1A, CEP85, CLPTM1, CNOT1, CNOT10, CNOT11, CNOT3, CNOT4, CNOT8, DDX1, DDX6, DZIP3, EDC3, EIF4ENIF1, FAM120A, FAM120C, FAM98A, FUBP3, FXR2, GIGYF1, GLE1, GPBP1, HELZ, IGF2BP2, KIAA0355, KIAA1671, LARP4B, MAGED1, KIAA0430, FAM195A, MEX3A, MOV10, NME7, NUPL2, OTUD4, PABPC1, PABPC4, PAN3, PATL1, PRRC2A, PRRC2B, PRRC2C, PUM1, PUM2, R3HDM1, R3HDM2, RBMS1, RC3H1, RC3H2, RPL11, SMAP2, SMG5, SMG7, SYNCRIP, TCHP, TDRD3, TNRC6A, TNRC6B, TNRC6C, TOP3B, UBAP2L, UPF1, USP54, YTHDF2, YTHDF3, ZCCHC11, DAZL, ELAVL1, FMR1, LSM14A, MEX3B, MKRN2, PAIP2, RBM47, UNK, YTHDF1, ZC3H7A, ZC3HAV1, ZFP36, CCDC77, CNOT6L, FAM193A, G3BP2, GPBP1L1, LSM12, RPTOR, SAMD4B, SHKBP1, TDRD7, TRIM56, ZCCHC3, DDX3X, FXR1, G3BP1, IGF2BP1, XRN1, AIFM1, C14orf166, TIAL1, UBAP2, DCP1B, YARS, KIF14, PHIP, SMARCA2, TAF1, TRIM66, AKAP1, UBQLN2, CPEB3, CPEB2, PURG, BSCL2, HOMEZ, HSPA5, HSPA9, KRT1, VIM, ACTB,

Top

Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
CPEB4	KIRP	chr5	173317154	173317154	T	G	Missense_Mutation	p.L140V	4
CPEB4	KIRP	chr5	173317605	173317605	G	-	Frame_Shift_Del	p.S290fs	4
CPEB4	UCEC	chr5	173316738	173316738	T	C	Missense_Mutation	p.M1T	3
CPEB4	UCEC	chr5	173372021	173372021	G	T	Missense_Mutation	p.G445V	3
CPEB4	LIHC	chr5	173382976	173382976	G	-	Frame_Shift_Del	p.G677fs	3
CPEB4	UCEC	chr5	173383061	173383061	G	A	Missense_Mutation	p.R704H	3
CPEB4	BRCA	chr5	173317753	173317753	A	G	Silent	p.A339	3
CPEB4	PAAD	chr5	173378900	173378900	A	C	Missense_Mutation	p.K580T	3
CPEB4	PAAD	chr5	173316988	173316988	A	G	Silent	p.Q84Q	3
CPEB4	PAAD	chr5	173337529	173337529	C	T	Missense_Mutation	p.R377C	3
CPEB4	HNSC	chr5	173337529	173337529	C	G	Missense_Mutation		3
CPEB4	STAD	chr5	173317434	173317434	A	G	Missense_Mutation	p.H233R	2
CPEB4	CESC	chr5	173317425	173317425	C	G	Nonsense_Mutation	p.S230*	2
CPEB4	ESCA	chr5	173370047	173370047	G	T	Missense_Mutation	p.R426M	2
CPEB4	UCEC	chr5	173317741	173317741	G	T	Missense_Mutation	p.K335N	2
CPEB4	SKCM	chr5	173337594	173337594	T	G	Missense_Mutation	p.N398K	2
CPEB4	STAD	chr5	173376544	173376544	C	A	Missense_Mutation	p.P497H	2
CPEB4	STAD	chr5	173317794	173317794	C	T	Missense_Mutation	p.S353F	2
CPEB4	LGG	chr5	173317440	173317440	A	T	Missense_Mutation	p.H235L	2
CPEB4	STAD	chr5	173383109	173383109	G	A	Missense_Mutation	p.R720H	2
CPEB4	UCEC	chr5	173317791	173317791	G	A	Missense_Mutation	p.S352N	2
CPEB4	SKCM	chr5	173317642	173317642	C	G	Silent	p.G302G	2
CPEB4	STAD	chr5	173378844	173378844	G	T	Missense_Mutation	p.W561C	2
CPEB4	STAD	chr5	173317326	173317326	C	T	Missense_Mutation	p.A197V	2
CPEB4	UCEC	chr5	173317792	173317792	C	G	Missense_Mutation	p.S352R	2
CPEB4	BLCA	chr5	173316947	173316947	C	G	Missense_Mutation	p.Q71E	2
CPEB4	HNSC	chr5	173376544	173376544	C	G	Missense_Mutation	p.P497R	2
CPEB4	SKCM	chr5	173372032	173372032	C	T	Missense_Mutation	p.L449F	2
CPEB4	STAD	chr5	173376580	173376580	A	G	Missense_Mutation	p.K509R	2
CPEB4	LGG	chr5	173378897	173378897	G	A	Missense_Mutation	p.R579Q	2
CPEB4	UCEC	chr5	173372016	173372016	C	A	Silent	p.G443	2
CPEB4	SKCM	chr5	173376543	173376543	C	T	Missense_Mutation	p.P497S	2
CPEB4	STAD	chr5	173380104	173380104	G	A	Silent	p.A597A	2
CPEB4	LIHC	chr5	173376527	173376527	T	-	Frame_Shift_Del	p.S491fs	2
CPEB4	ESCA	chr5	173317497	173317497	C	T	Missense_Mutation	p.A254V	2
CPEB4	UCEC	chr5	173372107	173372107	G	T	Missense_Mutation	p.V474L	2
CPEB4	BLCA	chr5	173317475	173317475	C	T	Nonsense_Mutation	p.Q247*	2
CPEB4	HNSC	chr5	173380196	173380196	C	T	Missense_Mutation	p.A628V	2
CPEB4	LUAD	chr5	173376573	173376573	G	T	Nonsense_Mutation	p.E507*	2
CPEB4	LIHC	chr5	173377061	173377061	C	-	Frame_Shift_Del	p.P549fs	2
CPEB4	ESCA	chr5	173378899	173378899	A	G	Missense_Mutation	p.K580E	2
CPEB4	STAD	chr5	173317732	173317732	G	A	Silent	p.S332S	2
CPEB4	UCEC	chr5	173372136	173372136	T	C	Silent	p.I483	2
CPEB4	HNSC	chr5	173359491	173359491	C	T	Silent	p.L416L	2
CPEB4	LIHC	chr5	173316743	173316743	G	T	Missense_Mutation		2
CPEB4	UCEC	chr5	173377042	173377042	C	A	Silent	p.L542	2
CPEB4	LUAD	chr5	173359497	173359497	A	G	Missense_Mutation	p.I418V	2
CPEB4	KIRP	chr5	173370039	173370039	T	G	Nonsense_Mutation	p.Y423X	2
CPEB4	UCEC	chr5	173380158	173380158	C	T	Silent	p.D615	2
CPEB4	LIHC	chr5	173382915	173382915	G	T	Silent		2
CPEB4	KIRP	chr5	173370039	173370039	T	G	Nonsense_Mutation	p.Y423*	2
CPEB4	UCEC	chr5	173317010	173317010	G	T	Nonsense_Mutation	p.E92*	2
CPEB4	STAD	chr5	173317507	173317507	T	C	Silent	p.H257H	2
CPEB4	UCEC	chr5	173380238	173380238	G	A	Missense_Mutation	p.R642H	2
CPEB4	CESC	chr5	173317731	173317731	C	T	Missense_Mutation		2
CPEB4	LGG	chr5	173317440	173317440	A	T	Missense_Mutation		2
CPEB4	STAD	chr5	173378883	173378883	G	A	Silent		2
CPEB4	UCEC	chr5	173317032	173317032	G	A	Missense_Mutation	p.S99N	2
CPEB4	STAD	chr5	173317108	173317108	G	A	Silent	p.S124S	2
CPEB4	UCEC	chr5	173383084	173383084	C	T	Missense_Mutation	p.P712S	2
CPEB4	KIRC	chr5	173372085	173372085	A	G	Silent	p.R466R	2
CPEB4	LIHC	chr5	173316743	173316743	G	T	Missense_Mutation	p.D3Y	2
CPEB4	PAAD	chr5	173316694	173316694	G	A	Translation_Start_Site		2
CPEB4	STAD	chr5	173378883	173378883	G	A	Silent	p.Q574Q	2
CPEB4	UCEC	chr5	173317477	173317477	G	T	Missense_Mutation	p.Q247H	2
CPEB4	KIRC	chr5	173317568	173317568	C	G	Missense_Mutation	p.L278V	1
CPEB4	LGG	chr5	173316959	173316959	T	G	Missense_Mutation		1
CPEB4	LUSC	chr5	173317590	173317590	G	T	Missense_Mutation	p.W285L	1
CPEB4	LIHC	chr5	173372134	173372134	A	G	Missense_Mutation	p.I483V	1
CPEB4	PRAD	chr5	173317158	173317158	C	A	Missense_Mutation	p.T141K	1
CPEB4	THCA	chr5	173317377	173317377	T	G	Missense_Mutation		1
CPEB4	LGG	chr5	173316976	173316977	AA	-	Frame_Shift_Del	p.80_80del	1
CPEB4	BLCA	chr5	173317561	173317561	G	T	Silent		1
CPEB4	HNSC	chr5	173376544	173376544	C	G	Missense_Mutation		1
CPEB4	LIHC	chr5	173317265	173317265	C	-	Frame_Shift_Del	p.P177fs	1
CPEB4	LGG	chr5	173378897	173378897	G	A	Missense_Mutation		1
CPEB4	LUSC	chr5	173317599	173317599	A	G	Missense_Mutation	p.Y288C	1
CPEB4	CESC	chr5	173317425	173317425	C	G	Nonsense_Mutation		1
CPEB4	KIRC	chr5	173316872	173316874	AAT	-	In_Frame_Del	p.45_46del	1
CPEB4	LIHC	chr5	173317577	173317577	C	-	Frame_Shift_Del	p.K280fs	1
CPEB4	PRAD	chr5	173317315	173317316	-	G	Frame_Shift_Ins	p.GG193fs	1
CPEB4	THCA	chr5	173317377	173317377	T	G	Missense_Mutation	p.V214G	1
CPEB4	ESCA	chr5	173372061	173372061	C	A	Nonsense_Mutation	p.C458*	1
CPEB4	BLCA	chr5	173317332	173317332	C	T	Missense_Mutation		1
CPEB4	HNSC	chr5	173317390	173317390	T	C	Silent		1
CPEB4	LIHC	chr5	173317269	173317269	C	-	Frame_Shift_Del	p.S180fs	1
CPEB4	LGG	chr5	173380103	173380103	C	T	Missense_Mutation		1
CPEB4	LUSC	chr5	173317235	173317235	G	T	Missense_Mutation	p.G167C	1
CPEB4	CESC	chr5	173317731	173317731	C	T	Missense_Mutation	p.S332L	1
CPEB4	KIRC	chr5	173370038	173370038	A	G	Missense_Mutation	p.Y423C	1
CPEB4	LIHC	chr5	173382953	173382953	A	T	Missense_Mutation	p.D668V	1
CPEB4	PRAD	chr5	173317603	173317603	G	T	Missense_Mutation	p.Q289H	1
CPEB4	THCA	chr5	173337561	173337561	G	A	Silent	p.E387E	1
CPEB4	ESCA	chr5	173383260	173383260	A	G	RNA	NULL	1
CPEB4	LGG	chr5	173380277	173380277	T	C	Missense_Mutation	p.V630A	1
CPEB4	LIHC	chr5	173317359	173317359	A	-	Frame_Shift_Del	p.Q208fs	1
CPEB4	LGG	chr5	173380277	173380277	T	C	Splice_Site		1
CPEB4	MESO	chr5	173337534	173337534	C	A	Silent		1
CPEB4	CESC	chr5	173383211	173383211	C	T	RNA	NULL	1
CPEB4	KIRC	chr5	173316872	173316874	AAT	-	In_Frame_Del	p.N48del	1
CPEB4	LIHC	chr5	173382915	173382915	G	T	Silent	p.V655V	1
CPEB4	PRAD	chr5	173317315	173317316	-	G	Frame_Shift_Ins	p.G194fs	1
CPEB4	THYM	chr5	173377073	173377073	G	T	Missense_Mutation	p.D553Y	1
CPEB4	ESCA	chr5	173383454	173383454	A	C	RNA	NULL	1
CPEB4	STAD	chr5	173317746	173317747	-	T	Frame_Shift_Ins	p.N337fs	1
CPEB4	BLCA	chr5	173359453	173359453	G	T	Splice_Site	p.G403V	1
CPEB4	HNSC	chr5	173337529	173337529	C	G	Missense_Mutation	p.R377G	1
CPEB4	LIHC	chr5	173317848	173317848	T	-	Frame_Shift_Del	p.I371fs	1
CPEB4	LIHC	chr5	173378937	173378937	A	G	Silent		1
CPEB4	OV	chr5	173249928	173249928	C	A	Missense_Mutation	p.P196T	1
CPEB4	COAD	chr5	173316900	173316900	G	A	Missense_Mutation	p.S55N	1
CPEB4	READ	chr5	173372101	173372101	C	T	Nonsense_Mutation	p.R472X	1
CPEB4	LGG	chr5	173380103	173380103	C	T	Missense_Mutation	p.A597V	1
CPEB4	STAD	chr5	173383101	173383101	C	T	Silent	p.G717G	1
CPEB4	LIHC	chr5	173316996	173316996	A	G	Missense_Mutation		1
CPEB4	PAAD	chr5	173316988	173316988	A	G	Silent		1
CPEB4	STAD	chr5	173359456	173359456	G	A	Missense_Mutation	p.R404H	1
CPEB4	COAD	chr5	173317524	173317525	AT	-	Frame_Shift_Del	p.263_263del	1
CPEB4	KIRP	chr5	173372036	173372036	A	G	Missense_Mutation	p.H450R	1
CPEB4	READ	chr5	173376531	173376531	C	T	Missense_Mutation	p.R493C	1
CPEB4	SKCM	chr5	173317643	173317643	G	T	Missense_Mutation	p.G303C	1
CPEB4	LGG	chr5	173316959	173316959	T	G	Missense_Mutation	p.L75V	1
CPEB4	BLCA	chr5	173317332	173317332	C	T	Missense_Mutation	p.S199L	1
CPEB4	LUAD	chr5	173376510	173376510	G	T	Splice_Site		1
CPEB4	PAAD	chr5	173378900	173378900	A	C	Missense_Mutation		1
CPEB4	STAD	chr5	173378896	173378896	C	T	Nonsense_Mutation	p.R579*	1
CPEB4	COAD	chr5	173317561	173317561	G	A	Silent	p.A275A	1
CPEB4	SARC	chr5	173372084	173372084	G	T	Missense_Mutation		1
CPEB4	SKCM	chr5	173317321	173317321	C	T	Silent	p.V195V	1
CPEB4	ESCA	chr5	173370047	173370047	G	T	Missense_Mutation		1
CPEB4	LGG	chr5	173317571	173317574	AACA	-	Frame_Shift_Del	p.NK279fs	1
CPEB4	STAD	chr5	173317464	173317465	-	CAGC	Frame_Shift_Ins	p.H243fs	1
CPEB4	HNSC	chr5	173317390	173317390	T	C	Silent	p.F218F	1
CPEB4	LGG	chr5	173380262	173380265	AGAT	-	Frame_Shift_Del	p.EI650fs	1
CPEB4	LIHC	chr5	173316585	173316585	T	G	Missense_Mutation		1
CPEB4	STAD	chr5	173378931	173378931	A	G	Silent	p.P590P	1
CPEB4	COAD	chr5	173317785	173317785	G	A	Missense_Mutation	p.R350H	1
CPEB4	LIHC	chr5	173317508	173317508	C	-	Frame_Shift_Del	p.P260fs	1
CPEB4	SARC	chr5	173383081	173383081	A	G	Missense_Mutation		1
CPEB4	SKCM	chr5	173382928	173382928	T	C	Missense_Mutation	p.Y660H	1
CPEB4	UCEC	chr5	173372136	173372136	T	C	Silent	p.I483I	1
CPEB4	GBM	chr5	173317554	173317554	A	-	Frame_Shift_Del	p.H273fs	1
CPEB4	STAD	chr5	173378896	173378896	C	T	Nonsense_Mutation	p.R579X	1
CPEB4	CESC	chr5	173376973	173376973	C	T	Silent		1
CPEB4	KIRC	chr5	173317715	173317715	C	-	Frame_Shift_Del	p.T326fs	1
CPEB4	LGG	chr5	173316976	173316977	AA	-	Frame_Shift_Del	p.AK80fs	1
CPEB4	LUAD	chr5	173380139	173380139	A	G	Missense_Mutation	p.Y609C	1
CPEB4	STAD	chr5	173317747	173317748	-	T	Frame_Shift_Ins	p.N337fs	1
CPEB4	COAD	chr5	173337544	173337544	G	A	Missense_Mutation	p.D382N	1
CPEB4	HNSC	chr5	173380196	173380196	C	T	Missense_Mutation		1
CPEB4	LIHC	chr5	173383110	173383110	C	-	Frame_Shift_Del	p.R720fs	1
CPEB4	SARC	chr5	173376570	173376570	G	T	Missense_Mutation		1
CPEB4	SKCM	chr5	173378909	173378909	T	G	Missense_Mutation	p.F583C	1
CPEB4	KIRC	chr5	173317385	173317385	G	A	Missense_Mutation	p.G217S	1
CPEB4	LUAD	chr5	173317337	173317337	A	G	Missense_Mutation	p.N201D	1
CPEB4	LIHC	chr5	173316557	173316557	A	T	Missense_Mutation		1
CPEB4	STAD	chr5	173317465	173317466	-	CAGC	Frame_Shift_Ins	p.H243fs	1
CPEB4	DLBC	chr5	173317293	173317293	A	C	Missense_Mutation	p.D186A	1
CPEB4	KIRP	chr5	173370039	173370039	T	G	Nonsense_Mutation		1
CPEB4	BLCA	chr5	173316947	173316947	C	G	Missense_Mutation		1
CPEB4	LIHC	chr5	173317366	173317366	C	-	Frame_Shift_Del	p.F210fs	1
CPEB4	SARC	chr5	173382924	173382924	G	T	Missense_Mutation		1
CPEB4	CESC	chr5	173376973	173376973	C	T	Silent	p.F519F	1
CPEB4	LGG	chr5	173316976	173316977	AA	-	Frame_Shift_Del		1
CPEB4	LUAD	chr5	173316776	173316776	A	C	Missense_Mutation	p.T14P	1
CPEB4	THCA	chr5	173337561	173337561	G	A	Silent		1
CPEB4	DLBC	chr5	173317237	173317237	T	C	Silent	p.G167G	1
CPEB4	KIRP	chr5	173317861	173317861	G	T	Silent		1
CPEB4	BLCA	chr5	173359453	173359453	G	T	Missense_Mutation		1
CPEB4	HNSC	chr5	173359491	173359491	C	T	Silent		1
CPEB4	LIHC	chr5	173317577	173317577	C	-	Frame_Shift_Del	p.P282fs	1
CPEB4	SARC	chr5	173317256	173317256	G	T	Missense_Mutation	p.A174S	1

Copy number variation (CNV) of CPEB4
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across CPEB4
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
93215	SARC	TCGA-DX-AB3A-01A	CPEB4	chr5	173337607	+	CEP112	chr17	64179425	-
68241	GBM	TCGA-14-1823-01A	CPEB4	chr5	173359503	+	NRCAM	chr7	107800937	-
83948	ESCA	TCGA-LN-A4A1-01A	CPEB4	chr5	173337607	+	SHISA5	chr3	48520666	-
84225	LUAD	TCGA-55-A491-01A	CPEB4	chr5	173380275	-	STK32A	chr5	146750217	+
88227	N/A	AI973221	KCNAB1	chr3	156259268	+	CPEB4	chr5	173385112	-
88227	N/A	EC565735	RCL1	chr9	4798410	-	CPEB4	chr5	173385198	+
88236	SARC	TCGA-3B-A9HR-01A	SUV420H1	chr11	67947599	-	CPEB4	chr5	173359453	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	CPEB4	0.000960695038624004	0.027
THYM	CPEB4	0.0318232949511979	0.86

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	CPEB4	0.0383962202472263	1
PAAD	CPEB4	0.0115290369590231	0.37
OV	CPEB4	0.0134737213540652	0.42
PCPG	CPEB4	0.0176043493350364	0.51
THYM	CPEB4	0.0151516890880473	0.45
SARC	CPEB4	0.00152354088353812	0.05

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source