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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: NOA1 (NCBI Gene ID:84273)

Gene Summary

Gene Summary

Gene Information	Gene Name: NOA1
	Gene ID: 84273
	Gene Symbol	NOA1
	Gene ID	84273
	Gene Name	nitric oxide associated 1
	Synonyms	C4orf14\|MTG3\|hAtNOS1\|hNOA1\|mAtNOS1
	Cytomap	4q12
	Type of Gene	protein-coding
	Description	nitric oxide-associated protein 1mitochondrial GTPase 3 homolognitric oxide synthase, mitochondrial (putative)putative ortholog of Arabidopsis mitochondrial nitric oxide synthase
	Modification date	20200313
	UniProtAcc	Q8NC60

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
NOA1	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'NOA1[title] AND translation [title] AND human.'

Gene	Title	PMID
NOA1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type

Translation factor

adj.pval

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with NOA1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type

Gene group

Translation factor

Correlated gene

Coefficient

Pvalue

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	NOA1	MRPS27	-2.1331392862776	0.000127527962379903
LUSC	NOA1	GRSF1	-2.76247896571529	0.00051492571390515
THCA	NOA1	GRSF1	-1.08941076587445	0.00125200545023797
COAD	NOA1	ERAL1	-5.44938149789995	0.00197160243988037
STAD	NOA1	NSUN4	-1.47162193095699	0.00256496202200651
COAD	NOA1	NSUN4	-1.80736528452028	0.00322914123535157
CHOL	NOA1	MRPL3	-2.68429255990621	0.00390625
ESCA	NOA1	ARPC5	-2.63391040316849	0.0048828125
ESCA	NOA1	MRPL3	-4.97897094908275	0.0048828125
LIHC	NOA1	ERAL1	1.12677134594174	0.00611535631403997
STAD	NOA1	MTG1	-1.43160368180665	0.018431528005749
STAD	NOA1	GRSF1	-1.47984951659237	0.0265949876047671
READ	NOA1	ERAL1	-2.05956459125571	0.03125
READ	NOA1	NSUN4	-3.48320980764672	0.03125
HNSC	NOA1	ERAL1	-3.60932051949886	0.0374699628314374
BLCA	NOA1	NSUN4	1.35737126636145	0.040130615234375
LUSC	NOA1	MTG1	-9.2533205847158	1.09583750788394e-07
KIRC	NOA1	ARPC5	-3.56956822261259	1.61870448444469e-11
KIRC	NOA1	MRPL3	1.69955762234244	1.97132191719422e-08
KIRP	NOA1	ARPC5	-2.24114749202761	2.00234353542328e-08
BRCA	NOA1	ERAL1	-3.2752869394705	2.01669698147401e-14
LUAD	NOA1	MRPS27	-2.46461120873599	2.13247131179291e-05
KICH	NOA1	ERAL1	2.20914300620918	4.54187393188476e-05
LUAD	NOA1	GRSF1	-2.60614624471738	4.74567569196557e-06
LUAD	NOA1	ERAL1	-1.9368176796655	5.86928774688463e-10
LUAD	NOA1	MTG1	-1.45502261953375	9.14904976982756e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with NOA1

ARF1, COL9A2, HSPA8, MPP3, ICT1, GRB10, BOK, LIN28A, ZNF346, TRA2A, TRMT10B, MRPS11, MRPS27, MRPS34, AURKAIP1, FGF8, MRPS15, KLHL22, CCDC59, MEPCE, RECQL4, MRM1, RC3H1, CSK, SNRNP70, PLEKHA4, HIST1H2BH, ESR1, IMMP2L, HSCB, ARHGEF11, AUH, C12orf65, C1QBP, C21orf33, C6orf203, MCUR1, CS, HINT2, MDH2, METTL17, MRPL11, MRPS12, MRPS26, MTERF3, MTIF2, MTRF1, MTRF1L, SSBP1, TRUB2, EXD2, AARS2, COX8A, PDHA1, NUDCD2, LIN28B, SRSF3, MRPS6, FAM120A, MRPS23, ATE1, RPS6, PNMA2, MRPS17, ZNF460, RPL27A, RBMS2, RPL19, GLI4, ZNF467, ZKSCAN8, MRPS18B, HNRNPU, MAGEB2, MRPS25, MRPS18C, APOBEC3C, SRSF1, MRPS2, SURF6, MCAT, MRPS9, ZNF574, RPL10, MRPS31, RPL13, ERAL1, RBM22, CCL14, Rbm14, MAP1LC3B,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
NOA1	chr4	57839419	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
NOA1	chr4	57843732	G	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
NOA1	COAD	chr4	57843320	57843320	A	G	Silent	p.C144C	9
NOA1	UCEC	chr4	57842757	57842757	T	C	Missense_Mutation	p.Q332R	3
NOA1	PRAD	chr4	57832797	57832797	T	C	Missense_Mutation	p.T585A	3
NOA1	UCS	chr4	57843010	57843010	T	G	Missense_Mutation	p.N248H	3
NOA1	UCEC	chr4	57842938	57842938	A	G	Missense_Mutation	p.C272R	3
NOA1	UCEC	chr4	57830593	57830593	C	T	Missense_Mutation	p.D622N	3
NOA1	BLCA	chr4	57829794	57829794	C	T	Missense_Mutation		3
NOA1	UCEC	chr4	57842835	57842835	G	A	Missense_Mutation	p.S306F	3
NOA1	LIHC	chr4	57842963	57842963	C	T	Silent		3
NOA1	LIHC	chr4	57842963	57842963	C	T	Silent	p.R263R	3
NOA1	COAD	chr4	57830572	57830572	C	A	Missense_Mutation	p.G629C	3
NOA1	UCEC	chr4	57834567	57834567	G	A	Missense_Mutation	p.R544C	2
NOA1	PCPG	chr4	57832876	57832876	G	A	Silent	p.V558V	2
NOA1	SARC	chr4	57832838	57832838	A	G	Missense_Mutation	p.L571S	2
NOA1	CESC	chr4	57830663	57830663	T	C	Silent		2
NOA1	STAD	chr4	57843622	57843622	G	A	Missense_Mutation		2
NOA1	STAD	chr4	57843622	57843622	G	A	Missense_Mutation	p.H44Y	2
NOA1	ESCA	chr4	57834566	57834566	C	T	Missense_Mutation	p.R544H	2
NOA1	SKCM	chr4	57840144	57840144	G	A	Missense_Mutation	p.P397S	2
NOA1	CESC	chr4	57829628	57829628	C	G	Missense_Mutation		2
NOA1	ESCA	chr4	57839424	57839424	C	T	Missense_Mutation	p.D469N	2
NOA1	PRAD	chr4	57842862	57842862	C	A	Missense_Mutation	p.G297V	2
NOA1	SKCM	chr4	57842672	57842672	C	T	Silent	p.E360E	2
NOA1	HNSC	chr4	57843128	57843128	C	G	Silent	p.A208A	2
NOA1	SKCM	chr4	57839469	57839469	G	A	Missense_Mutation	p.P454S	2
NOA1	ESCA	chr4	57834638	57834638	G	T	Missense_Mutation	p.P520Q	2
NOA1	SKCM	chr4	57842646	57842646	G	A	Missense_Mutation	p.S369F	2
NOA1	CHOL	chr4	57843464	57843464	T	C	Silent	p.Q96Q	2
NOA1	SARC	chr4	57843743	57843743	G	C	Silent		2
NOA1	ESCA	chr4	57842621	57842621	G	T	Silent		2
NOA1	UCEC	chr4	57829706	57829706	C	T	Silent	p.Q669	2
NOA1	PAAD	chr4	57843518	57843518	G	T	Silent		2
NOA1	SARC	chr4	57832838	57832838	A	G	Missense_Mutation		2
NOA1	UCEC	chr4	57832825	57832825	G	A	Silent	p.D575	2
NOA1	PAAD	chr4	57843518	57843518	G	T	Silent	p.I78I	2
NOA1	UCEC	chr4	57832876	57832876	G	A	Silent	p.V558	2
NOA1	ESCA	chr4	57842621	57842621	G	T	Silent	p.I377I	2
NOA1	KIRP	chr4	57842784	57842784	C	A	Missense_Mutation	p.G323V	2
NOA1	PCPG	chr4	57832876	57832876	G	A	Silent		2
NOA1	SARC	chr4	57843743	57843743	G	C	Silent	p.P3P	1
NOA1	BLCA	chr4	57829697	57829697	C	G	Missense_Mutation	p.K672N	1
NOA1	HNSC	chr4	57840083	57840085	TCT	-	In_Frame_Del		1
NOA1	BLCA	chr4	57842717	57842743	GCCCACTAAGTAGACGTCCCCACGGTA	-	In_Frame_Del	p.YRGDVYLVG337del	1
NOA1	LGG	chr4	57832878	57832878	C	A	Missense_Mutation	p.V558F	1
NOA1	LIHC	chr4	57839467	57839467	G	-	Frame_Shift_Del	p.P454fs	1
NOA1	SKCM	chr4	57832902	57832902	C	T	Splice_Site	p.G550_splice	1
NOA1	BLCA	chr4	57842717	57842743	GCCCACTAAGTAGACGTCCCCACGGTA	-	In_Frame_Del		1
NOA1	UCS	chr4	57843010	57843010	T	G	Missense_Mutation		1
NOA1	BLCA	chr4	57829640	57829640	C	A	Missense_Mutation	p.K691N	1
NOA1	HNSC	chr4	57843128	57843128	C	G	Silent		1
NOA1	LGG	chr4	57843046	57843046	C	T	Missense_Mutation	p.A236T	1
NOA1	LIHC	chr4	57840106	57840106	T	-	Frame_Shift_Del	p.K409fs	1
NOA1	BLCA	chr4	57840060	57840060	G	C	Missense_Mutation		1
NOA1	COAD	chr4	57843728	57843728	G	A	Silent	p.F8F	1
NOA1	UCEC	chr4	57832825	57832825	G	A	Silent	p.D575D	1
NOA1	SARC	chr4	57843743	57843743	G	C	Silent	p.P3	1
NOA1	BLCA	chr4	57842717	57842717	G	T	Silent	p.G345G	1
NOA1	HNSC	chr4	57842906	57842906	G	A	Silent		1
NOA1	CESC	chr4	57830591	57830591	G	T	Missense_Mutation		1
NOA1	LGG	chr4	57829700	57829700	G	C	Missense_Mutation	p.I671M	1
NOA1	LIHC	chr4	57840041	57840041	T	-	Frame_Shift_Del	p.K431fs	1
NOA1	BLCA	chr4	57842852	57842852	C	T	Silent		1
NOA1	PRAD	chr4	57843409	57843409	G	A	Nonsense_Mutation	p.Q115*	1
NOA1	BLCA	chr4	57842668	57842668	C	T	Missense_Mutation	p.D362N	1
NOA1	HNSC	chr4	57843655	57843655	C	G	Missense_Mutation		1
NOA1	LGG	chr4	57834617	57834617	C	G	Missense_Mutation	p.R527T	1
NOA1	LUAD	chr4	57839404	57839404	G	C	Missense_Mutation	p.H475Q	1
NOA1	STAD	chr4	57839516	57839516	C	T	Missense_Mutation	p.R438K	1
NOA1	BLCA	chr4	57829646	57829646	C	T	Silent		1
NOA1	UCEC	chr4	57829706	57829706	C	T	Silent	p.Q669Q	1
NOA1	BLCA	chr4	57840060	57840060	G	C	Missense_Mutation	p.Q425E	1
NOA1	CESC	chr4	57829628	57829628	C	G	Missense_Mutation	p.K695N	1
NOA1	LGG	chr4	57832852	57832852	C	T	Silent	p.V566V	1
NOA1	LUAD	chr4	57843023	57843023	C	T	Silent	p.L243L	1
NOA1	STAD	chr4	57842918	57842918	C	G	Silent	p.L278L	1
NOA1	BLCA	chr4	57843603	57843603	C	T	Missense_Mutation		1
NOA1	ESCA	chr4	57842621	57842621	G	T	Silent	p.I377	1
NOA1	PRAD	chr4	57829644	57829644	C	A	Missense_Mutation	p.R690M	1
NOA1	BLCA	chr4	57842852	57842852	C	T	Silent	p.P300P	1
NOA1	HNSC	chr4	57843655	57843655	C	G	Missense_Mutation	p.E33Q	1
NOA1	CESC	chr4	57829794	57829794	C	G	Missense_Mutation	p.R640T	1
NOA1	LUAD	chr4	57843074	57843074	C	G	Silent	p.L226L	1
NOA1	STAD	chr4	57843591	57843591	T	G	Missense_Mutation	p.Y54S	1
NOA1	READ	chr4	57839402	57839402	T	G	Missense_Mutation	p.K476T	1
NOA1	UCEC	chr4	57830572	57830572	C	A	Missense_Mutation	p.G629_splice	1
NOA1	LGG	chr4	57832852	57832852	C	T	Silent		1
NOA1	BLCA	chr4	57829646	57829646	C	T	Silent	p.V689V	1
NOA1	HNSC	chr4	57843646	57843646	A	G	Missense_Mutation	p.C36R	1
NOA1	LUSC	chr4	57842861	57842861	C	A	Silent	p.G297G	1
NOA1	STAD	chr4	57834643	57834643	A	C	Silent	p.V518V	1
NOA1	BLCA	chr4	57839436	57839436	C	G	Missense_Mutation		1
NOA1	HNSC	chr4	57842906	57842906	G	A	Silent	p.G282G	1
NOA1	LGG	chr4	57829700	57829700	G	C	Missense_Mutation		1
NOA1	SKCM	chr4	57829744	57829744	G	A	Missense_Mutation	p.P657S	1
NOA1	BLCA	chr4	57829794	57829794	C	T	Missense_Mutation	p.R640K	1
NOA1	BLCA	chr4	57829697	57829697	C	G	Missense_Mutation		1
NOA1	COAD	chr4	57829669	57829669	G	A	Missense_Mutation	p.P682S	1
NOA1	LUSC	chr4	57843150	57843150	T	A	Missense_Mutation	p.Y201F	1
NOA1	THCA	chr4	57839419	57839419	A	G	Silent		1
NOA1	SARC	chr4	57842744	57842744	G	T	Silent		1
NOA1	BLCA	chr4	57840102	57840102	A	G	Missense_Mutation		1
NOA1	ESCA	chr4	57839424	57839424	C	T	Missense_Mutation		1
NOA1	BLCA	chr4	57839436	57839436	C	G	Missense_Mutation	p.D465H	1
NOA1	HNSC	chr4	57840083	57840085	TCT	-	In_Frame_Del	p.ED416del	1
NOA1	SKCM	chr4	57829662	57829662	G	A	Missense_Mutation	p.S684F	1
NOA1	BLCA	chr4	57829640	57829640	C	A	Missense_Mutation		1
NOA1	COAD	chr4	57829751	57829751	G	A	Silent	p.T654T	1
NOA1	THCA	chr4	57839479	57839479	C	A	Missense_Mutation		1
NOA1	BLCA	chr4	57842875	57842875	C	T	Missense_Mutation		1
NOA1	ESCA	chr4	57834566	57834566	C	T	Missense_Mutation		1
NOA1	BLCA	chr4	57840102	57840102	A	G	Missense_Mutation	p.S411P	1
NOA1	KIRC	chr4	57842813	57842813	C	T	Silent	p.V313V	1
NOA1	SKCM	chr4	57840106	57840106	T	G	Missense_Mutation	p.K409N	1
NOA1	BLCA	chr4	57842717	57842717	G	T	Silent		1
NOA1	THYM	chr4	57829677	57829677	G	T	Missense_Mutation		1
NOA1	SARC	chr4	57840126	57840126	T	C	Missense_Mutation		1
NOA1	BLCA	chr4	57840116	57840116	C	G	Missense_Mutation		1
NOA1	BLCA	chr4	57840116	57840116	C	G	Missense_Mutation	p.R406T	1
NOA1	LIHC	chr4	57829751	57829751	G	-	Frame_Shift_Del	p.T654fs	1
NOA1	SKCM	chr4	57832903	57832903	C	T	Splice_Site		1
NOA1	BLCA	chr4	57842668	57842668	C	T	Missense_Mutation		1
NOA1	COAD	chr4	57843295	57843295	C	A	Missense_Mutation	p.A153S	1
NOA1	THYM	chr4	57829677	57829677	G	T	Missense_Mutation	p.T679N	1

Copy number variation (CNV) of NOA1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across NOA1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
63750	BRCA	TCGA-E2-A1IO-01A	ARHGAP24	chr4	86643125	+	NOA1	chr4	57840188	-
63750	N/A	FN144233	LAMC2	chr1	183202184	+	NOA1	chr4	57840175	-
80600	BLCA	TCGA-K4-A83P-01A	NOA1	chr4	57834550	-	ATP10D	chr4	47525029	+
76152	BRCA	TCGA-AO-A12D-01A	NOA1	chr4	57832786	-	PPP3CA	chr4	102117273	-
92354	BRCA	TCGA-BH-A18U-01A	NOA1	chr4	57839314	-	SPINK2	chr4	57686745	-
63769	SARC	TCGA-KD-A5QU-01A	PDE4D	chr5	58476421	-	NOA1	chr4	57840188	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source