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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: GFM2 (NCBI Gene ID:84340)

Gene Summary

Gene Summary

Gene Information	Gene Name: GFM2
	Gene ID: 84340
	Gene Symbol	GFM2
	Gene ID	84340
	Gene Name	GTP dependent ribosome recycling factor mitochondrial 2
	Synonyms	EF-G2mt\|EFG2\|MRRF2\|MST027\|MSTP027\|RRF\|RRF2\|RRF2mt\|hEFG2\|mEF-G 2
	Cytomap	5q13.3
	Type of Gene	protein-coding
	Description	ribosome-releasing factor 2, mitochondrialG elongation factor mitochondrial 2mitochondrial elongation factor G2mitochondrial ribosome recycling factor 2ribosome releasing factor 2
	Modification date	20200313
	UniProtAcc	Q969S9

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006415	Translational termination
GO:0032543	Mitochondrial translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GFM2	GO:0032543	mitochondrial translation	19716793
Hgene	GFM2	GO:0032790	ribosome disassembly	19716793
Hgene	GFM2	GO:0070125	mitochondrial translational elongation	19716793

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
GFM2	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'GFM2[title] AND translation [title] AND human.'

Gene	Title	PMID
GFM2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000296805	74021464	74021580	Frame-shift
ENST00000509430	74021464	74021580	Frame-shift
ENST00000296805	74026084	74026223	Frame-shift
ENST00000509430	74026084	74026223	Frame-shift
ENST00000296805	74034326	74034467	In-frame
ENST00000509430	74034326	74034467	In-frame
ENST00000296805	74041929	74041990	Frame-shift
ENST00000509430	74041929	74041990	Frame-shift
ENST00000296805	74047192	74047318	In-frame
ENST00000509430	74047192	74047318	In-frame
ENST00000296805	74054673	74054771	Frame-shift
ENST00000509430	74054673	74054771	Frame-shift
ENST00000509430	74060859	74060977	3UTR-3UTR

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000509430	74034326	74034467	3064	1390	1530	779	360	406
ENST00000296805	74034326	74034467	3266	1538	1678	779	360	406
ENST00000509430	74047192	74047318	3064	615	740	779	101	143
ENST00000296805	74047192	74047318	3266	763	888	779	101	143

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q969S9	101	143	1	779	Chain	ID=PRO_0000007450;Note=Ribosome-releasing factor 2%2C mitochondrial
Q969S9	360	406	1	779	Chain	ID=PRO_0000007450;Note=Ribosome-releasing factor 2%2C mitochondrial
Q969S9	101	143	1	779	Chain	ID=PRO_0000007450;Note=Ribosome-releasing factor 2%2C mitochondrial
Q969S9	360	406	1	779	Chain	ID=PRO_0000007450;Note=Ribosome-releasing factor 2%2C mitochondrial
Q969S9	101	143	68	353	Domain	Note=tr-type G
Q969S9	101	143	68	353	Domain	Note=tr-type G
Q969S9	101	143	141	145	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|HAMAP-Rule:MF_03059
Q969S9	101	143	141	145	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|HAMAP-Rule:MF_03059
Q969S9	360	406	361	407	Alternative sequence	ID=VSP_001363;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.4
Q969S9	360	406	361	407	Alternative sequence	ID=VSP_001363;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.4

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
THCA	GFM2	1.24335152208863	0.000405886158765646
KIRP	GFM2	-3.00163848603689	0.0044123362749815
LUSC	GFM2	-1.44135486663635	0.00981186007251347
KIRC	GFM2	-2.05005965144326	3.97470828213212e-07
LUAD	GFM2	-3.28752735953651	9.23397908905824e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
STAD	GFM2	-0.070658518	0.011150679
PCPG	GFM2	-0.109775824	0.020563833
THCA	GFM2	-0.174526996	0.038882607
LIHC	GFM2	0.045663564	0.045984387

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with GFM2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	GFM2	GGCX	0.813670322	1.09E-11
CHOL	Cell metabolism gene	GFM2	INHBC	0.81900503	6.18E-12
CHOL	Cell metabolism gene	GFM2	MOCS2	0.822763483	4.10E-12
CHOL	IUPHAR	GFM2	GGCX	0.813670322	1.09E-11
SKCM	IUPHAR	GFM2	SLC25A46	0.801044935	2.95E-107
SKCM	IUPHAR	GFM2	SLC30A5	0.822546429	8.98E-118
TGCT	Cell metabolism gene	GFM2	ELOVL6	0.800814932	4.13E-36
TGCT	Cell metabolism gene	GFM2	DCP2	0.836498554	4.49E-42
TGCT	CGC	GFM2	RAD17	0.842993235	2.58E-43
TGCT	Epifactor	GFM2	TDRKH	0.807817256	3.51E-37
TGCT	TF	GFM2	ZNF607	0.800129195	5.23E-36
TGCT	TF	GFM2	ZNF131	0.827932226	1.61E-40
THYM	Cell metabolism gene	GFM2	HSPA9	0.813731016	4.70E-30
UCS	Cell metabolism gene	GFM2	HSPA9	0.813731016	4.70E-30
UVM	Cell metabolism gene	GFM2	NUP50	0.800053277	5.50E-19
UVM	Cell metabolism gene	GFM2	MTMR6	0.80030809	5.26E-19
UVM	Cell metabolism gene	GFM2	POLR3F	0.800326365	5.24E-19
UVM	Cell metabolism gene	GFM2	HMGCS1	0.80073988	4.88E-19
UVM	Cell metabolism gene	GFM2	CPOX	0.802093963	3.84E-19
UVM	Cell metabolism gene	GFM2	BPNT1	0.803326991	3.09E-19
UVM	Cell metabolism gene	GFM2	MANEA	0.803497738	3.00E-19
UVM	Cell metabolism gene	GFM2	XRN2	0.804209044	2.64E-19
UVM	Cell metabolism gene	GFM2	ETNK1	0.805723228	2.01E-19
UVM	Cell metabolism gene	GFM2	PIK3R1	0.808927134	1.12E-19
UVM	Cell metabolism gene	GFM2	GLS	0.808934911	1.12E-19
UVM	Cell metabolism gene	GFM2	CCT2	0.810053253	9.12E-20
UVM	Cell metabolism gene	GFM2	XPO1	0.81061891	8.21E-20
UVM	Cell metabolism gene	GFM2	PPP1CB	0.810672128	8.13E-20
UVM	Cell metabolism gene	GFM2	UGP2	0.810964029	7.70E-20
UVM	Cell metabolism gene	GFM2	TXNRD1	0.811536636	6.92E-20
UVM	Cell metabolism gene	GFM2	PANK3	0.811949533	6.41E-20
UVM	Cell metabolism gene	GFM2	IPMK	0.812266345	6.04E-20
UVM	Cell metabolism gene	GFM2	GPAM	0.812739736	5.52E-20
UVM	Cell metabolism gene	GFM2	UGGT2	0.813178696	5.09E-20
UVM	Cell metabolism gene	GFM2	SDHD	0.813987263	4.37E-20
UVM	Cell metabolism gene	GFM2	NUP54	0.814616422	3.87E-20
UVM	Cell metabolism gene	GFM2	EDEM3	0.814783045	3.75E-20
UVM	Cell metabolism gene	GFM2	SRP19	0.818322297	1.90E-20
UVM	Cell metabolism gene	GFM2	MINPP1	0.819377327	1.55E-20
UVM	Cell metabolism gene	GFM2	HMGCR	0.822190759	8.88E-21
UVM	Cell metabolism gene	GFM2	L2HGDH	0.822754669	7.93E-21
UVM	Cell metabolism gene	GFM2	FPGT	0.823285106	7.13E-21
UVM	Cell metabolism gene	GFM2	PMPCB	0.823540006	6.78E-21
UVM	Cell metabolism gene	GFM2	PRKAA1	0.824762378	5.30E-21
UVM	Cell metabolism gene	GFM2	GNPNAT1	0.824772148	5.29E-21
UVM	Cell metabolism gene	GFM2	DDX20	0.824881541	5.17E-21
UVM	Cell metabolism gene	GFM2	FBXL3	0.825370064	4.68E-21
UVM	Cell metabolism gene	GFM2	GXYLT1	0.825654332	4.42E-21
UVM	Cell metabolism gene	GFM2	SMG1	0.830653851	1.57E-21
UVM	Cell metabolism gene	GFM2	CLOCK	0.832333868	1.10E-21
UVM	Cell metabolism gene	GFM2	PIKFYVE	0.832434684	1.08E-21
UVM	Cell metabolism gene	GFM2	MED21	0.833551045	8.50E-22
UVM	Cell metabolism gene	GFM2	GNPDA2	0.83386365	7.95E-22
UVM	Cell metabolism gene	GFM2	NUP107	0.834715592	6.62E-22
UVM	Cell metabolism gene	GFM2	ACADM	0.836488399	4.50E-22
UVM	Cell metabolism gene	GFM2	PIK3CA	0.83699873	4.03E-22
UVM	Cell metabolism gene	GFM2	COL4A3BP	0.837457241	3.64E-22
UVM	Cell metabolism gene	GFM2	IDI1	0.840493837	1.86E-22
UVM	Cell metabolism gene	GFM2	TNPO1	0.841227703	1.57E-22
UVM	Cell metabolism gene	GFM2	NAMPT	0.844386113	7.65E-23
UVM	Cell metabolism gene	GFM2	MED17	0.845933391	5.35E-23
UVM	Cell metabolism gene	GFM2	NUDT12	0.847252251	3.93E-23
UVM	Cell metabolism gene	GFM2	GRPEL2	0.850636961	1.75E-23
UVM	Cell metabolism gene	GFM2	RANBP2	0.852375214	1.15E-23
UVM	Cell metabolism gene	GFM2	PSMC6	0.854554257	6.72E-24
UVM	Cell metabolism gene	GFM2	AASDHPPT	0.855756927	4.98E-24
UVM	Cell metabolism gene	GFM2	AGPS	0.857472229	3.23E-24
UVM	Cell metabolism gene	GFM2	CSGALNACT2	0.859024578	2.17E-24
UVM	Cell metabolism gene	GFM2	DCP2	0.860272933	1.58E-24
UVM	Cell metabolism gene	GFM2	C1GALT1	0.860273514	1.58E-24
UVM	Cell metabolism gene	GFM2	DBT	0.861249227	1.22E-24
UVM	Cell metabolism gene	GFM2	CNOT8	0.862694172	8.36E-25
UVM	Cell metabolism gene	GFM2	PHAX	0.868266712	1.85E-25
UVM	Cell metabolism gene	GFM2	PNPLA8	0.86905487	1.49E-25
UVM	Cell metabolism gene	GFM2	NUPL2	0.870993889	8.66E-26
UVM	Cell metabolism gene	GFM2	SACM1L	0.881282898	4.15E-27
UVM	CGC	GFM2	STAG1	0.801930988	3.95E-19
UVM	CGC	GFM2	KIF5B	0.80357681	2.95E-19
UVM	CGC	GFM2	GOLGA5	0.803780499	2.85E-19
UVM	CGC	GFM2	USP8	0.803918154	2.78E-19
UVM	CGC	GFM2	ARHGAP5	0.803934447	2.77E-19
UVM	CGC	GFM2	DEK	0.804892888	2.33E-19
UVM	CGC	GFM2	ETNK1	0.805723228	2.01E-19
UVM	CGC	GFM2	FBXO11	0.805731906	2.01E-19
UVM	CGC	GFM2	PMS1	0.805918597	1.94E-19
UVM	CGC	GFM2	AFF4	0.805987503	1.92E-19
UVM	CGC	GFM2	PIK3R1	0.808927134	1.12E-19
UVM	CGC	GFM2	POT1	0.809962753	9.27E-20
UVM	CGC	GFM2	XPO1	0.81061891	8.21E-20
UVM	CGC	GFM2	SDHD	0.813987263	4.37E-20
UVM	CGC	GFM2	IL6ST	0.816120192	2.91E-20
UVM	CGC	GFM2	ARID2	0.817308725	2.31E-20
UVM	CGC	GFM2	CDC73	0.817462727	2.25E-20
UVM	CGC	GFM2	MAP3K1	0.818864373	1.71E-20
UVM	CGC	GFM2	TRIM33	0.819807903	1.42E-20
UVM	CGC	GFM2	ABI1	0.821234219	1.07E-20
UVM	CGC	GFM2	SMAD4	0.821457949	1.03E-20
UVM	CGC	GFM2	APC	0.822262588	8.75E-21
UVM	CGC	GFM2	DICER1	0.827942335	2.77E-21
UVM	CGC	GFM2	PHF6	0.830664651	1.57E-21
UVM	CGC	GFM2	RGPD3	0.833444604	8.70E-22
UVM	CGC	GFM2	ATR	0.836499464	4.49E-22
UVM	CGC	GFM2	PIK3CA	0.83699873	4.03E-22
UVM	CGC	GFM2	MLLT10	0.840390118	1.90E-22
UVM	CGC	GFM2	MALT1	0.8410131	1.65E-22
UVM	CGC	GFM2	SF3B1	0.841688354	1.42E-22
UVM	CGC	GFM2	STAG2	0.845706397	5.64E-23
UVM	CGC	GFM2	RANBP2	0.852375214	1.15E-23
UVM	CGC	GFM2	ATF1	0.855909539	4.79E-24
UVM	CGC	GFM2	SUZ12	0.859651189	1.85E-24
UVM	CGC	GFM2	DDX5	0.861738445	1.08E-24
UVM	CGC	GFM2	ERCC4	0.864522815	5.14E-25
UVM	CGC	GFM2	PALB2	0.865150692	4.34E-25
UVM	CGC	GFM2	MSH2	0.86595856	3.49E-25
UVM	CGC	GFM2	RAD17	0.868806943	1.60E-25
UVM	Epifactor	GFM2	USP15	0.801700665	4.12E-19
UVM	Epifactor	GFM2	TDG	0.804149518	2.67E-19
UVM	Epifactor	GFM2	UBR2	0.804447178	2.53E-19
UVM	Epifactor	GFM2	DEK	0.804892888	2.33E-19
UVM	Epifactor	GFM2	NSL1	0.805201523	2.21E-19
UVM	Epifactor	GFM2	WAC	0.805494297	2.09E-19
UVM	Epifactor	GFM2	FAM175A	0.805743882	2.00E-19
UVM	Epifactor	GFM2	UCHL5	0.806242836	1.83E-19
UVM	Epifactor	GFM2	UIMC1	0.807042217	1.58E-19
UVM	Epifactor	GFM2	MBIP	0.811034601	7.60E-20
UVM	Epifactor	GFM2	TAF1	0.812190698	6.12E-20
UVM	Epifactor	GFM2	DDX21	0.812512814	5.76E-20
UVM	Epifactor	GFM2	NIPBL	0.815259907	3.43E-20
UVM	Epifactor	GFM2	SENP1	0.815666122	3.17E-20
UVM	Epifactor	GFM2	JMJD1C	0.815710318	3.15E-20
UVM	Epifactor	GFM2	DDX50	0.816135947	2.90E-20
UVM	Epifactor	GFM2	RLIM	0.816391873	2.76E-20
UVM	Epifactor	GFM2	ARID2	0.817308725	2.31E-20
UVM	Epifactor	GFM2	CDC73	0.817462727	2.25E-20
UVM	Epifactor	GFM2	ACTR6	0.817870399	2.07E-20
UVM	Epifactor	GFM2	HAT1	0.818525151	1.83E-20
UVM	Epifactor	GFM2	TRIM33	0.819807903	1.42E-20
UVM	Epifactor	GFM2	CHD9	0.820123256	1.34E-20
UVM	Epifactor	GFM2	PCGF6	0.820232445	1.31E-20
UVM	Epifactor	GFM2	PPP4R2	0.821552724	1.01E-20
UVM	Epifactor	GFM2	CUL5	0.822174266	8.91E-21
UVM	Epifactor	GFM2	PHF20	0.823469087	6.88E-21
UVM	Epifactor	GFM2	PRKAA1	0.824762378	5.30E-21
UVM	Epifactor	GFM2	TADA1	0.824964898	5.09E-21
UVM	Epifactor	GFM2	SMEK2	0.826151898	4.00E-21
UVM	Epifactor	GFM2	EPC2	0.826700481	3.57E-21
UVM	Epifactor	GFM2	ZMYND11	0.826714906	3.56E-21
UVM	Epifactor	GFM2	UBE2B	0.826974864	3.38E-21
UVM	Epifactor	GFM2	TLK1	0.829047313	2.20E-21
UVM	Epifactor	GFM2	DNTTIP2	0.829644036	1.94E-21
UVM	Epifactor	GFM2	ANKRD32	0.831894971	1.21E-21
UVM	Epifactor	GFM2	CLOCK	0.832333868	1.10E-21
UVM	Epifactor	GFM2	CHUK	0.835134593	6.05E-22
UVM	Epifactor	GFM2	SMEK1	0.835353528	5.77E-22
UVM	Epifactor	GFM2	ATR	0.836499464	4.49E-22
UVM	Epifactor	GFM2	SIRT1	0.837836124	3.35E-22
UVM	Epifactor	GFM2	ATF2	0.838367064	2.98E-22
UVM	Epifactor	GFM2	MLLT10	0.840390118	1.90E-22
UVM	Epifactor	GFM2	SF3B1	0.841688354	1.42E-22
UVM	Epifactor	GFM2	BRCC3	0.841898687	1.35E-22
UVM	Epifactor	GFM2	TAF7	0.844145891	8.09E-23
UVM	Epifactor	GFM2	EPC1	0.844959854	6.70E-23
UVM	Epifactor	GFM2	RMI1	0.850129361	1.98E-23
UVM	Epifactor	GFM2	CHD1	0.850409332	1.85E-23
UVM	Epifactor	GFM2	PARG	0.856145857	4.52E-24
UVM	Epifactor	GFM2	TAF9	0.858134315	2.73E-24
UVM	Epifactor	GFM2	ZRANB3	0.859375282	1.99E-24
UVM	Epifactor	GFM2	SUZ12	0.859651189	1.85E-24
UVM	Epifactor	GFM2	YEATS4	0.866201526	3.27E-25
UVM	Epifactor	GFM2	FAM175B	0.866246544	3.23E-25
UVM	Epifactor	GFM2	YY1	0.875804232	2.16E-26
UVM	Epifactor	GFM2	CUL2	0.883412209	2.13E-27
UVM	IUPHAR	GFM2	HMGCS1	0.80073988	4.88E-19
UVM	IUPHAR	GFM2	IRAK4	0.80130853	4.41E-19
UVM	IUPHAR	GFM2	MAP3K2	0.802027628	3.89E-19
UVM	IUPHAR	GFM2	ATP11B	0.803111295	3.21E-19
UVM	IUPHAR	GFM2	HIPK3	0.803480821	3.00E-19
UVM	IUPHAR	GFM2	PRPF4B	0.803990183	2.74E-19
UVM	IUPHAR	GFM2	MAPK9	0.804885543	2.34E-19
UVM	IUPHAR	GFM2	TBK1	0.804943625	2.31E-19
UVM	IUPHAR	GFM2	FBXO11	0.805731906	2.01E-19
UVM	IUPHAR	GFM2	CLK4	0.805898167	1.95E-19
UVM	IUPHAR	GFM2	NEK1	0.806010531	1.91E-19
UVM	IUPHAR	GFM2	PIK3R1	0.808927134	1.12E-19
UVM	IUPHAR	GFM2	GLS	0.808934911	1.12E-19
UVM	IUPHAR	GFM2	MAPK8	0.810189272	8.89E-20
UVM	IUPHAR	GFM2	XPO1	0.81061891	8.21E-20
UVM	IUPHAR	GFM2	SLK	0.810636705	8.18E-20
UVM	IUPHAR	GFM2	TAF1	0.812190698	6.12E-20
UVM	IUPHAR	GFM2	SENP1	0.815666122	3.17E-20
UVM	IUPHAR	GFM2	JMJD1C	0.815710318	3.15E-20
UVM	IUPHAR	GFM2	PKN2	0.815888471	3.04E-20
UVM	IUPHAR	GFM2	IL6ST	0.816120192	2.91E-20
UVM	IUPHAR	GFM2	XIAP	0.818326084	1.90E-20
UVM	IUPHAR	GFM2	HAT1	0.818525151	1.83E-20
UVM	IUPHAR	GFM2	MAP3K1	0.818864373	1.71E-20
UVM	IUPHAR	GFM2	TRIM33	0.819807903	1.42E-20
UVM	IUPHAR	GFM2	TNKS2	0.820746774	1.18E-20
UVM	IUPHAR	GFM2	HMGCR	0.822190759	8.88E-21
UVM	IUPHAR	GFM2	STK38L	0.82300514	7.55E-21
UVM	IUPHAR	GFM2	TRPM7	0.823475258	6.87E-21
UVM	IUPHAR	GFM2	PRKAA1	0.824762378	5.30E-21
UVM	IUPHAR	GFM2	ZMYND11	0.826714906	3.56E-21
UVM	IUPHAR	GFM2	USP1	0.826731931	3.55E-21
UVM	IUPHAR	GFM2	TLK1	0.829047313	2.20E-21
UVM	IUPHAR	GFM2	SMG1	0.830653851	1.57E-21
UVM	IUPHAR	GFM2	CLOCK	0.832333868	1.10E-21
UVM	IUPHAR	GFM2	PIKFYVE	0.832434684	1.08E-21
UVM	IUPHAR	GFM2	CHUK	0.835134593	6.05E-22
UVM	IUPHAR	GFM2	ATR	0.836499464	4.49E-22
UVM	IUPHAR	GFM2	CSNK1A1	0.836549031	4.45E-22
UVM	IUPHAR	GFM2	MFN1	0.836616534	4.38E-22
UVM	IUPHAR	GFM2	PIK3CA	0.83699873	4.03E-22
UVM	IUPHAR	GFM2	RIOK3	0.837678207	3.47E-22
UVM	IUPHAR	GFM2	SIRT1	0.837836124	3.35E-22
UVM	IUPHAR	GFM2	NR2C1	0.838662039	2.79E-22
UVM	IUPHAR	GFM2	RIOK2	0.839036039	2.57E-22
UVM	IUPHAR	GFM2	IDI1	0.840493837	1.86E-22
UVM	IUPHAR	GFM2	MALT1	0.8410131	1.65E-22
UVM	IUPHAR	GFM2	YES1	0.84656754	4.61E-23
UVM	IUPHAR	GFM2	SLC25A24	0.852481423	1.12E-23
UVM	IUPHAR	GFM2	SLC25A40	0.853184897	9.43E-24
UVM	IUPHAR	GFM2	BIRC2	0.853554418	8.61E-24
UVM	IUPHAR	GFM2	SCYL2	0.868895407	1.56E-25
UVM	IUPHAR	GFM2	USP14	0.870814027	9.11E-26
UVM	IUPHAR	GFM2	SLC25A46	0.88358632	2.02E-27
UVM	IUPHAR	GFM2	SLC30A5	0.887198574	6.34E-28
UVM	IUPHAR	GFM2	CSNK1G3	0.891214538	1.67E-28
UVM	Kinase	GFM2	IRAK4	0.80130853	4.41E-19
UVM	Kinase	GFM2	MAP3K2	0.802027628	3.89E-19
UVM	Kinase	GFM2	HIPK3	0.803480821	3.00E-19
UVM	Kinase	GFM2	PRPF4B	0.803990183	2.74E-19
UVM	Kinase	GFM2	MAPK9	0.804885543	2.34E-19
UVM	Kinase	GFM2	TBK1	0.804943625	2.31E-19
UVM	Kinase	GFM2	CLK4	0.805898167	1.95E-19
UVM	Kinase	GFM2	NEK1	0.806010531	1.91E-19
UVM	Kinase	GFM2	MAPK8	0.810189272	8.89E-20
UVM	Kinase	GFM2	SLK	0.810636705	8.18E-20
UVM	Kinase	GFM2	TAF1	0.812190698	6.12E-20
UVM	Kinase	GFM2	PKN2	0.815888471	3.04E-20
UVM	Kinase	GFM2	MAP3K1	0.818864373	1.71E-20
UVM	Kinase	GFM2	TRIM33	0.819807903	1.42E-20
UVM	Kinase	GFM2	STK38L	0.82300514	7.55E-21
UVM	Kinase	GFM2	TRPM7	0.823475258	6.87E-21
UVM	Kinase	GFM2	PRKAA1	0.824762378	5.30E-21
UVM	Kinase	GFM2	TLK1	0.829047313	2.20E-21
UVM	Kinase	GFM2	SMG1	0.830653851	1.57E-21
UVM	Kinase	GFM2	CHUK	0.835134593	6.05E-22
UVM	Kinase	GFM2	ATR	0.836499464	4.49E-22
UVM	Kinase	GFM2	CSNK1A1	0.836549031	4.45E-22
UVM	Kinase	GFM2	COL4A3BP	0.837457241	3.64E-22
UVM	Kinase	GFM2	RIOK3	0.837678207	3.47E-22
UVM	Kinase	GFM2	RIOK2	0.839036039	2.57E-22
UVM	Kinase	GFM2	YES1	0.84656754	4.61E-23
UVM	Kinase	GFM2	SCYL2	0.868895407	1.56E-25
UVM	Kinase	GFM2	CSNK1G3	0.891214538	1.67E-28
UVM	TF	GFM2	HDX	0.800650874	4.95E-19
UVM	TF	GFM2	ZNF397	0.800720867	4.89E-19
UVM	TF	GFM2	IKZF5	0.801949981	3.94E-19
UVM	TF	GFM2	ZNF800	0.802172489	3.79E-19
UVM	TF	GFM2	ZNF23	0.80242761	3.62E-19
UVM	TF	GFM2	MEF2A	0.802667781	3.47E-19
UVM	TF	GFM2	ZNF780B	0.802730073	3.43E-19
UVM	TF	GFM2	ZNF91	0.803049154	3.24E-19
UVM	TF	GFM2	NKRF	0.803142574	3.19E-19
UVM	TF	GFM2	TMF1	0.804361647	2.57E-19
UVM	TF	GFM2	DMTF1	0.804760354	2.39E-19
UVM	TF	GFM2	ZFX	0.805317809	2.16E-19
UVM	TF	GFM2	TOPORS	0.805717144	2.01E-19
UVM	TF	GFM2	AHCTF1	0.807029814	1.59E-19
UVM	TF	GFM2	ZNF12	0.807606346	1.43E-19
UVM	TF	GFM2	ELF2	0.80804401	1.32E-19
UVM	TF	GFM2	ZNF443	0.808064575	1.31E-19
UVM	TF	GFM2	ZNF195	0.808897288	1.13E-19
UVM	TF	GFM2	ZC3H8	0.809736797	9.66E-20
UVM	TF	GFM2	PRDM10	0.809785429	9.58E-20
UVM	TF	GFM2	ZNF33A	0.810532284	8.34E-20
UVM	TF	GFM2	ZNF24	0.812286195	6.01E-20
UVM	TF	GFM2	VEZF1	0.813142753	5.12E-20
UVM	TF	GFM2	ZNF441	0.813668078	4.64E-20
UVM	TF	GFM2	ZNF280D	0.813727368	4.59E-20
UVM	TF	GFM2	ZNF614	0.814107486	4.27E-20
UVM	TF	GFM2	ZNF37A	0.814126392	4.25E-20
UVM	TF	GFM2	RLF	0.814583269	3.90E-20
UVM	TF	GFM2	ZNF510	0.815259474	3.43E-20
UVM	TF	GFM2	ZNF17	0.815945994	3.01E-20
UVM	TF	GFM2	ZNF234	0.816150185	2.89E-20
UVM	TF	GFM2	ZNF277	0.817036728	2.44E-20
UVM	TF	GFM2	ARID2	0.817308725	2.31E-20
UVM	TF	GFM2	ZNF143	0.817798418	2.10E-20
UVM	TF	GFM2	ZNF761	0.819034337	1.65E-20
UVM	TF	GFM2	ZNF26	0.819340283	1.56E-20
UVM	TF	GFM2	ZNF140	0.819582404	1.49E-20
UVM	TF	GFM2	ZNF45	0.819832637	1.42E-20
UVM	TF	GFM2	ZNF184	0.819925687	1.39E-20
UVM	TF	GFM2	PCGF6	0.820232445	1.31E-20
UVM	TF	GFM2	CEBPZ	0.820561916	1.23E-20
UVM	TF	GFM2	ZNF813	0.821298868	1.06E-20
UVM	TF	GFM2	SMAD4	0.821457949	1.03E-20
UVM	TF	GFM2	ZNF527	0.82220125	8.86E-21
UVM	TF	GFM2	ZNF569	0.823142993	7.34E-21
UVM	TF	GFM2	ZNF283	0.823164336	7.31E-21
UVM	TF	GFM2	THAP9	0.823413262	6.95E-21
UVM	TF	GFM2	PHF20	0.823469087	6.88E-21
UVM	TF	GFM2	ZNF181	0.823945816	6.25E-21
UVM	TF	GFM2	ZNF326	0.826089513	4.05E-21
UVM	TF	GFM2	ZNF613	0.826254177	3.91E-21
UVM	TF	GFM2	ZNF845	0.826305627	3.87E-21
UVM	TF	GFM2	ZNF658	0.826906986	3.42E-21
UVM	TF	GFM2	FOXN2	0.827251521	3.19E-21
UVM	TF	GFM2	ZBTB6	0.827496065	3.03E-21
UVM	TF	GFM2	ZNF160	0.82808075	2.69E-21
UVM	TF	GFM2	ZNF627	0.828276819	2.58E-21
UVM	TF	GFM2	THAP5	0.828281412	2.58E-21
UVM	TF	GFM2	ZNF644	0.828968379	2.24E-21
UVM	TF	GFM2	ZFP62	0.829202673	2.13E-21
UVM	TF	GFM2	ZNF461	0.830205918	1.73E-21
UVM	TF	GFM2	ZNF701	0.830809885	1.52E-21
UVM	TF	GFM2	ZNF354B	0.83083964	1.51E-21
UVM	TF	GFM2	ZNF507	0.831691841	1.26E-21
UVM	TF	GFM2	ZNF227	0.831704747	1.26E-21
UVM	TF	GFM2	ZNF600	0.83178106	1.24E-21
UVM	TF	GFM2	CLOCK	0.832333868	1.10E-21
UVM	TF	GFM2	GABPA	0.832640051	1.03E-21
UVM	TF	GFM2	ZNF383	0.832848835	9.88E-22
UVM	TF	GFM2	ZNF430	0.83288284	9.81E-22
UVM	TF	GFM2	ZNF567	0.832918926	9.73E-22
UVM	TF	GFM2	ZNF148	0.83322739	9.11E-22
UVM	TF	GFM2	THAP6	0.8333741	8.83E-22
UVM	TF	GFM2	ZNF558	0.833802692	8.06E-22
UVM	TF	GFM2	ZNF782	0.834057931	7.63E-22
UVM	TF	GFM2	ZNF611	0.834267496	7.29E-22
UVM	TF	GFM2	ZNF268	0.836994084	4.03E-22
UVM	TF	GFM2	ZFP14	0.837032506	4.00E-22
UVM	TF	GFM2	ZNF235	0.837560173	3.56E-22
UVM	TF	GFM2	ATF2	0.838367064	2.98E-22
UVM	TF	GFM2	NR2C1	0.838662039	2.79E-22
UVM	TF	GFM2	ZBTB1	0.84329043	9.85E-23
UVM	TF	GFM2	ZNF146	0.845297474	6.20E-23
UVM	TF	GFM2	MYNN	0.845606054	5.77E-23
UVM	TF	GFM2	ZNF347	0.847203328	3.97E-23
UVM	TF	GFM2	ZNF440	0.847284311	3.90E-23
UVM	TF	GFM2	ZNF254	0.847520319	3.69E-23
UVM	TF	GFM2	ZNF432	0.849067283	2.55E-23
UVM	TF	GFM2	ZNF136	0.84926922	2.43E-23
UVM	TF	GFM2	ZNF14	0.850779988	1.69E-23
UVM	TF	GFM2	ZBTB11	0.851262297	1.51E-23
UVM	TF	GFM2	ATF1	0.855909539	4.79E-24
UVM	TF	GFM2	ZNF791	0.857003427	3.64E-24
UVM	TF	GFM2	ZNF468	0.858527222	2.47E-24
UVM	TF	GFM2	ZNF180	0.861554124	1.13E-24
UVM	TF	GFM2	ZNF585A	0.866888614	2.71E-25
UVM	TF	GFM2	NFXL1	0.866999358	2.63E-25
UVM	TF	GFM2	ZNF354A	0.867294353	2.42E-25
UVM	TF	GFM2	SP3	0.869363716	1.37E-25
UVM	TF	GFM2	ZNF28	0.872255039	6.05E-26
UVM	TF	GFM2	ZNF320	0.873267527	4.53E-26
UVM	TF	GFM2	YY1	0.875804232	2.16E-26
UVM	TF	GFM2	GPBP1	0.883908808	1.82E-27
UVM	TF	GFM2	ZNF41	0.884014975	1.76E-27
UVM	TF	GFM2	ZNF420	0.887173786	6.39E-28
UVM	TF	GFM2	SMAD5	0.89343234	7.80E-29
UVM	TF	GFM2	ZNF131	0.909516252	1.81E-31
UVM	TSG	GFM2	CCAR1	0.800720476	4.89E-19
UVM	TSG	GFM2	LIN9	0.803955075	2.76E-19
UVM	TSG	GFM2	DMTF1	0.804760354	2.39E-19
UVM	TSG	GFM2	MAPK9	0.804885543	2.34E-19
UVM	TSG	GFM2	TOPORS	0.805717144	2.01E-19
UVM	TSG	GFM2	INTS6	0.806685142	1.69E-19
UVM	TSG	GFM2	UIMC1	0.807042217	1.58E-19
UVM	TSG	GFM2	VEZT	0.807641716	1.42E-19
UVM	TSG	GFM2	RFWD2	0.808189338	1.28E-19
UVM	TSG	GFM2	SKP2	0.80979095	9.57E-20
UVM	TSG	GFM2	GGNBP2	0.811091293	7.52E-20
UVM	TSG	GFM2	RINT1	0.8120937	6.24E-20
UVM	TSG	GFM2	RBBP8	0.813838006	4.49E-20
UVM	TSG	GFM2	SDHD	0.813987263	4.37E-20
UVM	TSG	GFM2	ARID2	0.817308725	2.31E-20
UVM	TSG	GFM2	CDC73	0.817462727	2.25E-20
UVM	TSG	GFM2	COPS2	0.818396895	1.87E-20
UVM	TSG	GFM2	SMAD4	0.821457949	1.03E-20
UVM	TSG	GFM2	CUL5	0.822174266	8.91E-21
UVM	TSG	GFM2	APC	0.822262588	8.75E-21
UVM	TSG	GFM2	ECT2	0.822463871	8.41E-21
UVM	TSG	GFM2	PRKAA1	0.824762378	5.30E-21
UVM	TSG	GFM2	ZMYND11	0.826714906	3.56E-21
UVM	TSG	GFM2	RCHY1	0.827211752	3.22E-21
UVM	TSG	GFM2	DICER1	0.827942335	2.77E-21
UVM	TSG	GFM2	SMCHD1	0.83028611	1.70E-21
UVM	TSG	GFM2	PHF6	0.830664651	1.57E-21
UVM	TSG	GFM2	TANK	0.834470677	6.98E-22
UVM	TSG	GFM2	CHUK	0.835134593	6.05E-22
UVM	TSG	GFM2	ATR	0.836499464	4.49E-22
UVM	TSG	GFM2	CSNK1A1	0.836549031	4.45E-22
UVM	TSG	GFM2	SIRT1	0.837836124	3.35E-22
UVM	TSG	GFM2	WDR11	0.840880287	1.70E-22
UVM	TSG	GFM2	FAM188A	0.842990806	1.05E-22
UVM	TSG	GFM2	KRIT1	0.846694575	4.48E-23
UVM	TSG	GFM2	USP33	0.848159379	3.17E-23
UVM	TSG	GFM2	CHD1	0.850409332	1.85E-23
UVM	TSG	GFM2	SUZ12	0.859651189	1.85E-24
UVM	TSG	GFM2	DCLRE1A	0.859732052	1.81E-24
UVM	TSG	GFM2	PPM1A	0.860355963	1.54E-24
UVM	TSG	GFM2	PALB2	0.865150692	4.34E-25
UVM	TSG	GFM2	MSH2	0.86595856	3.49E-25
UVM	TSG	GFM2	CUL2	0.883412209	2.13E-27

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRC	GFM2	MRPL20	1.48585631024503	0.000111704804180407
KIRP	GFM2	MTRF1L	-1.31576362507347	0.000177780166268349
COAD	GFM2	MTRF1L	-1.15162723948358	0.000411599874496461
LUAD	GFM2	MRPL20	-3.00071204707904	0.000452706327224566
BRCA	GFM2	MRPL20	-1.74379528461375	0.000756034430433012
KICH	GFM2	MRRF	1.86992130954506	0.0014527440071106
COAD	GFM2	ERAL1	-5.44938149789995	0.00197160243988037
LIHC	GFM2	MTRF1	-3.09442355715565	0.0048209944049292
COAD	GFM2	MTIF3	1.61088953830673	0.00561287999153138
LIHC	GFM2	ERAL1	1.12677134594174	0.00611535631403997
COAD	GFM2	MTRF1	1.47985135182376	0.00729089975357057
STAD	GFM2	TFB2M	-1.29447697619286	0.00828406633809209
STAD	GFM2	MTIF3	-1.25397254610668	0.0093395933508873
LIHC	GFM2	MRPL20	-1.08735154161025	0.0158079482509981
BRCA	GFM2	MTRF1	1.22201104478671	0.0180265605125636
CHOL	GFM2	MTRF1	-4.61466528468525	0.02734375
LIHC	GFM2	MRRF	-1.19805818879659	0.0305924082275009
READ	GFM2	ERAL1	-2.05956459125571	0.03125
HNSC	GFM2	ERAL1	-3.60932051949886	0.0374699628314374
BRCA	GFM2	C7orf55	1.11017906914305	1.98134744241926e-09
BRCA	GFM2	ERAL1	-3.2752869394705	2.01669698147401e-14
PRAD	GFM2	MRRF	-1.56810957454655	2.74398347191128e-05
KICH	GFM2	ERAL1	2.20914300620918	4.54187393188476e-05
BRCA	GFM2	MTIF3	-1.57382804516009	4.69602801583771e-07
KICH	GFM2	MTRF1L	-2.04766510138049	5.38825988769531e-05
LUSC	GFM2	MTIF3	1.14980970601281	5.67568378344708e-05
LUAD	GFM2	ERAL1	-1.9368176796655	5.86928774688463e-10
HNSC	GFM2	C7orf55	1.67126463172142	7.65438699090738e-07
KIRC	GFM2	MTRF1	-4.93943424334119	9.90629858601199e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with GFM2

TRIM27, VPS52, BANP, TRIM9, RARS2, MRPL2, RPL17, RPS5, Cct3, SQSTM1, PSG8, YBEY, NDUFS7, BPNT1, MRPL12, TUFM, TRIM41, FAM107A, NT5C3A, TNFRSF10A, TP53, PLEKHA4, ACOT1, ACOT2, AFG3L2, ALAS1, ATP5B, ATP5D, ATP5J2-PTCD1, ATP5F1, ATP5H, ATP5J, ATP5O, ATPAF1, BCS1L, C17orf80, COQ5, DAP3, DBT, DHX30, DLST, ECHS1, ELAC2, ERAL1, ETFA, ETFB, FASTKD2, GADD45GIP1, GLS, GLUD1, GRSF1, GTPBP10, HINT2, IARS2, IBA57, LARS2, LETM1, LRPPRC, MMAB, MRPL10, MRPL13, MRPL15, MRPL17, MRPL19, MRPL20, MRPL21, MRPL24, MRPL28, MRPL37, MRPL39, MRPL4, MRPL41, MRPL42, MRPL43, MRPL44, MRPL45, MRPL46, MRPL47, MRPL49, MRPL50, MRPL52, MRPL53, MRPL9, MRPS10, MRPS14, MRPS16, MRPS17, MRPS18B, MRPS2, MRPS22, MRPS23, MRPS24, MRPS25, MRPS26, MRPS27, MRPS28, MRPS30, MRPS31, MRPS33, MRPS34, MRPS35, MRPS36, MRPS5, MRPS6, MRPS7, MRPS9, MTERF3, NDUFA12, NDUFA2, NDUFA5, NDUFA6, NDUFA7, NDUFA9, NDUFAF2, NDUFAF4, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS6, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NFS1, NME4, OGDH, OXA1L, PDHA1, PDK3, PDPR, PNPT1, POLDIP2, POLG, PPIF, PTCD3, PYCR1, PYCR2, RBMX, SHMT2, SLC30A9, SLIRP, SRSF9, SSX2IP, STOML2, TACO1, TIMM44, TRA2A, TRA2B, TRMT10C, C10orf2, VWA8, WDR5, CALM1, BCL2L12, BEX4, LAMTOR5, UQCRFS1, PTCD1, MALSU1, NPTN, LCN8, ATP5L2, YARS2, FAHD1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
GFM2	chr5	74017499	C	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74017533	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74017590	G	C	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74017607	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74017770	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74017808	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74018077	A	AAACTT	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74018282	TC	T	Deletion	Uncertain_significance	not_provided	SO:0001589\|frameshift_variant,SO:0001619\|non-coding_transcript_variant	SO:0001589\|frameshift_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74018333	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
GFM2	chr5	74018387	C	T	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_39	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
GFM2	chr5	74021135	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74021201	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74021473	C	T	single_nucleotide_variant	Likely_benign	not_specified\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74021474	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
GFM2	chr5	74021509	A	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74021755	G	A	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74021798	A	G	single_nucleotide_variant	Benign/Likely_benign	not_specified\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74021846	TACTCAA	T	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001822\|inframe_deletion	SO:0001619\|non-coding_transcript_variant,SO:0001822\|inframe_deletion
GFM2	chr5	74021863	A	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
GFM2	chr5	74021872	A	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
GFM2	chr5	74021950	A	T	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_39\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74022105	CAGAG	C	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74022220	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74026071	G	A	single_nucleotide_variant	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74026093	C	T	single_nucleotide_variant	Benign	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
GFM2	chr5	74026376	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74028752	G	GAC	Microsatellite	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74028752	GAC	G	Microsatellite	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74028752	GACAC	G	Microsatellite	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74028752	GACACAC	G	Microsatellite	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74028752	GACACACAC	G	Microsatellite	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74028752	GACACACACAC	G	Microsatellite	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74028803	A	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74028893	C	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74028911	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74029056	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74029160	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74029160	G	GA	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74029160	GA	G	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74032707	G	A	single_nucleotide_variant	Likely_benign	not_specified\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74032744	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74032755	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74032772	A	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
GFM2	chr5	74032811	C	T	single_nucleotide_variant	Pathogenic	not_provided	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
GFM2	chr5	74032837	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74032897	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74033944	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74034032	C	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74034229	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74034234	A	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74034245	G	A	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74034318	T	G	single_nucleotide_variant	Likely_benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74034324	T	TA	Duplication	Likely_pathogenic	not_provided	SO:0001575\|splice_donor_variant,SO:0001627\|intron_variant	SO:0001575\|splice_donor_variant,SO:0001627\|intron_variant
GFM2	chr5	74034351	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
GFM2	chr5	74034359	C	T	single_nucleotide_variant	Benign	not_specified	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
GFM2	chr5	74034400	G	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
GFM2	chr5	74034445	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
GFM2	chr5	74035504	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74035823	T	C	single_nucleotide_variant	Likely_benign	not_specified	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74035853	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74035892	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74035914	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74035959	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74036029	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74036155	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74036248	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74037350	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74037369	C	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
GFM2	chr5	74037386	T	A	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74037452	A	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74037505	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74041306	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74041318	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74041329	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74041496	A	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74041575	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
GFM2	chr5	74041786	A	AT	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74041922	CA	C	Deletion	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74041962	CT	C	Deletion	Pathogenic	Combined_oxidative_phosphorylation_deficiency_39\|Mitochondrial_disease	SO:0001589\|frameshift_variant,SO:0001619\|non-coding_transcript_variant	SO:0001589\|frameshift_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74041994	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74042228	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74043556	C	T	single_nucleotide_variant	Likely_pathogenic	Combined_oxidative_phosphorylation_deficiency_39\|Mitochondrial_disease\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74043583	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74043783	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74046223	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74046462	C	T	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_39	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74046464	C	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
GFM2	chr5	74046473	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
GFM2	chr5	74046495	A	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74046656	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74047233	A	C	single_nucleotide_variant	Likely_benign	not_specified	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74047436	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74054595	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74054696	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
GFM2	chr5	74054701	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74054703	T	G	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_39\|Mitochondrial_disease	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74054792	AG	A	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74055190	T	C	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_39	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74055200	A	G	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_39	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74055209	T	C	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74055222	G	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74055256	TGAAAA	CGAAAG	Indel	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74055564	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74056513	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74056766	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74056788	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
GFM2	chr5	74056813	TAGTAAAGAGAAAAA	T	Deletion	Likely_pathogenic	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74059375	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74059525	T	C	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74059553	CAA	C	Deletion	Uncertain_significance	not_specified	SO:0001589\|frameshift_variant,SO:0001619\|non-coding_transcript_variant	SO:0001589\|frameshift_variant,SO:0001619\|non-coding_transcript_variant
GFM2	chr5	74059708	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74059770	T	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74059815	GT	G	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74059826	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74059851	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74061081	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GFM2	chr5	74062764	T	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
GFM2	chr5	74062881	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
GFM2	chr5	74063069	G	A	single_nucleotide_variant	Benign	not_provided

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
GFM2	BLCA	chr5	74055209	74055209	T	C	Missense_Mutation		7
GFM2	LIHC	chr5	74021847	74021852	ACTCAA	-	In_Frame_Del		4
GFM2	ESCA	chr5	74021855	74021855	T	A	Missense_Mutation	p.E608V	4
GFM2	PAAD	chr5	74026139	74026139	C	T	Missense_Mutation	p.G558R	3
GFM2	LIHC	chr5	74047313	74047313	C	T	Missense_Mutation	p.D104N	3
GFM2	BRCA	chr5	74026192	74026192	A	G	Missense_Mutation	p.I540T	3
GFM2	ACC	chr5	74028894	74028894	G	A	Missense_Mutation	p.R514C	3
GFM2	LIHC	chr5	74017499	74017499	C	T	Missense_Mutation		3
GFM2	KIRP	chr5	74026107	74026107	G	T	Silent	p.I568I	3
GFM2	LIHC	chr5	74047313	74047313	C	T	Missense_Mutation		3
GFM2	SKCM	chr5	74046440	74046440	A	C	Silent	p.G161G	2
GFM2	STAD	chr5	74034228	74034228	C	T	Missense_Mutation		2
GFM2	UCEC	chr5	74021912	74021912	A	G	Missense_Mutation	p.V589A	2
GFM2	BRCA	chr5	74047198	74047198	G	A	Missense_Mutation	p.T142I	2
GFM2	LGG	chr5	74034187	74034187	A	C	Missense_Mutation	p.S426A	2
GFM2	SKCM	chr5	74032749	74032749	G	A	Missense_Mutation	p.A461V	2
GFM2	LIHC	chr5	74021922	74021922	T	-	Frame_Shift_Del	p.R586fs	2
GFM2	UCEC	chr5	74021922	74021922	T	G	Silent	p.R586	2
GFM2	BRCA	chr5	74047238	74047238	T	C	Missense_Mutation	p.T129A	2
GFM2	LGG	chr5	74034187	74034187	A	C	Missense_Mutation		2
GFM2	SKCM	chr5	74034150	74034150	A	T	Missense_Mutation	p.L438H	2
GFM2	STAD	chr5	74034228	74034228	C	T	Missense_Mutation	p.R412H	2
GFM2	PAAD	chr5	74026094	74026094	G	T	Missense_Mutation	p.R573S	2
GFM2	UCEC	chr5	74028873	74028873	C	T	Missense_Mutation	p.V521M	2
GFM2	SKCM	chr5	74046460	74046460	A	G	Missense_Mutation	p.C155R	2
GFM2	UCEC	chr5	74034435	74034435	G	A	Missense_Mutation	p.A371V	2
GFM2	CESC	chr5	74017486	74017486	C	G	Missense_Mutation		2
GFM2	KIRC	chr5	74021853	74021853	A	T	Missense_Mutation	p.F609I	2
GFM2	STAD	chr5	74028900	74028900	G	A	Missense_Mutation	p.L512F	2
GFM2	UCEC	chr5	74041628	74041628	C	A	Nonsense_Mutation	p.E242*	2
GFM2	TGCT	chr5	74037386	74037386	T	A	Missense_Mutation		2
GFM2	STAD	chr5	74041649	74041649	C	T	Missense_Mutation	p.V235M	2
GFM2	UCEC	chr5	74043556	74043556	C	T	Missense_Mutation	p.R190Q	2
GFM2	LIHC	chr5	74026206	74026206	C	G	Missense_Mutation	p.M535I	2
GFM2	BLCA	chr5	74035829	74035829	C	G	Missense_Mutation	p.R355P	2
GFM2	STAD	chr5	74034388	74034388	G	A	Missense_Mutation	p.R387C	2
GFM2	LIHC	chr5	74037421	74037421	T	C	Missense_Mutation		2
GFM2	KIRP	chr5	74018240	74018240	T	G	Missense_Mutation	p.K725N	2
GFM2	BLCA	chr5	74054712	74054712	C	T	Missense_Mutation	p.R89K	2
GFM2	HNSC	chr5	74018254	74018254	G	A	Missense_Mutation	p.R721C	2
GFM2	LIHC	chr5	74034219	74034219	A	-	Frame_Shift_Del	p.L415fs	2
GFM2	STAD	chr5	74026203	74026203	C	A	Silent	p.G536G	2
GFM2	CHOL	chr5	74021852	74021852	A	T	Missense_Mutation	p.F609Y	2
GFM2	LIHC	chr5	74026206	74026206	C	G	Missense_Mutation		2
GFM2	LIHC	chr5	74041558	74041558	T	-	Frame_Shift_Del	p.N265fs	2
GFM2	HNSC	chr5	74017519	74017519	A	G	Silent	p.D767D	2
GFM2	SKCM	chr5	74046476	74046476	G	A	Silent	p.T149T	2
GFM2	LIHC	chr5	74043544	74043544	A	-	Frame_Shift_Del	p.L194fs	2
GFM2	UCEC	chr5	74021779	74021779	G	A	Silent	p.S665S	1
GFM2	BLCA	chr5	74021929	74021930	-	C	Frame_Shift_Ins	p.G583fs	1
GFM2	HNSC	chr5	74041581	74041581	C	G	Missense_Mutation	p.E257D	1
GFM2	PAAD	chr5	74026139	74026139	C	T	Missense_Mutation		1
GFM2	STAD	chr5	74034392	74034392	A	-	Frame_Shift_Del	p.F385fs	1
GFM2	COAD	chr5	74021847	74021852	ACTCAA	-	In_Frame_Del	p.609_611del	1
GFM2	KIRP	chr5	74026107	74026107	G	T	Silent		1
GFM2	LIHC	chr5	74032646	74032646	T	C	Silent		1
GFM2	BLCA	chr5	74021829	74021829	C	G	Missense_Mutation		1
GFM2	HNSC	chr5	74035904	74035904	C	G	Missense_Mutation		1
GFM2	LIHC	chr5	74018284	74018284	T	-	Frame_Shift_Del	p.R712fs	1
GFM2	HNSC	chr5	74034158	74034158	A	T	Silent	p.T435T	1
GFM2	PAAD	chr5	74026094	74026094	G	T	Missense_Mutation		1
GFM2	STAD	chr5	74026118	74026118	G	A	Nonsense_Mutation	p.R565*	1
GFM2	COAD	chr5	74046464	74046464	C	T	Silent	p.E153E	1
GFM2	LIHC	chr5	74034181	74034181	T	C	Missense_Mutation		1
GFM2	BLCA	chr5	74021929	74021930	-	-	Frame_Shift_Ins		1
GFM2	HNSC	chr5	74018254	74018254	G	A	Missense_Mutation		1
GFM2	STAD	chr5	74034392	74034392	A	-	Frame_Shift_Del	p.M386fs	1
GFM2	HNSC	chr5	74046424	74046424	C	G	Missense_Mutation	p.D167H	1
GFM2	COAD	chr5	74054695	74054695	C	T	Missense_Mutation	p.G95R	1
GFM2	BLCA	chr5	74041974	74041974	C	G	Missense_Mutation	p.E209Q	1
GFM2	HNSC	chr5	74034158	74034158	A	T	Silent		1
GFM2	LIHC	chr5	74026202	74026202	C	-	Frame_Shift_Del	p.E537fs	1
GFM2	STAD	chr5	74028896	74028896	T	C	Missense_Mutation	p.Q513R	1
GFM2	HNSC	chr5	74026194	74026195	-	T	Frame_Shift_Ins	p.H539fs	1
GFM2	DLBC	chr5	74037369	74037369	C	T	Silent	p.L305L	1
GFM2	LIHC	chr5	74028915	74028915	G	T	Missense_Mutation	p.H507N	1
GFM2	STAD	chr5	74047274	74047274	G	A	Nonsense_Mutation	p.R117*	1
GFM2	BLCA	chr5	74018260	74018260	G	A	Nonsense_Mutation	p.Q719*	1
GFM2	HNSC	chr5	74021841	74021841	C	G	Missense_Mutation		1
GFM2	LIHC	chr5	74047264	74047264	C	-	Frame_Shift_Del	p.G120fs	1
GFM2	STAD	chr5	74047274	74047274	G	A	Nonsense_Mutation	p.R117X	1
GFM2	PAAD	chr5	74047308	74047308	A	C	Missense_Mutation	p.D105E	1
GFM2	LIHC	chr5	74018369	74018369	A	C	Missense_Mutation	p.D682E	1
GFM2	SKCM	chr5	74032630	74032631	-	A	Frame_Shift_Ins	p.K501_Q502delinsX	1
GFM2	STAD	chr5	74054702	74054702	G	A	Silent	p.Y92Y	1
GFM2	BLCA	chr5	74026190	74026190	C	G	Missense_Mutation	p.E541Q	1
GFM2	HNSC	chr5	74026194	74026195	-	-	Frame_Shift_Ins		1
GFM2	LIHC	chr5	74054728	74054728	T	-	Frame_Shift_Del	p.T87fs	1
GFM2	LIHC	chr5	74037369	74037369	C	T	Silent		1
GFM2	PRAD	chr5	74056731	74056731	T	C	Silent	p.L48L	1
GFM2	CESC	chr5	74055228	74055228	A	G	Missense_Mutation		1
GFM2	KIRC	chr5	74021464	74021464	C	A	Splice_Site		1
GFM2	GBM	chr5	74028894	74028894	G	A	Missense_Mutation	p.R546C	1
GFM2	LIHC	chr5	74021934	74021934	A	C	Missense_Mutation	p.L582V	1
GFM2	SKCM	chr5	74041656	74041656	G	A	Silent	p.F232F	1
GFM2	BLCA	chr5	74035894	74035894	C	G	Silent	p.L333L	1
GFM2	HNSC	chr5	74046424	74046424	C	G	Missense_Mutation		1
GFM2	LUAD	chr5	74026156	74026156	C	G	Missense_Mutation	p.G552A	1
GFM2	READ	chr5	74037379	74037379	T	C	Missense_Mutation	p.N302S	1
GFM2	CESC	chr5	74032653	74032653	G	A	Missense_Mutation		1
GFM2	KIRP	chr5	74017604	74017604	T	C	Missense_Mutation	p.Y739C	1
GFM2	BLCA	chr5	74026190	74026190	C	G	Missense_Mutation		1
GFM2	GBM	chr5	74041590	74041590	T	C	Silent	p.K286K	1
GFM2	SKCM	chr5	74034151	74034151	G	A	Missense_Mutation	p.L438F	1
GFM2	TGCT	chr5	74046464	74046464	C	T	Silent		1
GFM2	HNSC	chr5	74035904	74035904	C	G	Missense_Mutation	p.G330A	1
GFM2	LUAD	chr5	74032775	74032775	G	C	Silent	p.S452S	1
GFM2	READ	chr5	74021496	74021496	A	C	Missense_Mutation	p.I619S	1
GFM2	CESC	chr5	74018345	74018345	C	C	Missense_Mutation		1
GFM2	BLCA	chr5	74035894	74035894	C	G	Silent		1
GFM2	GBM	chr5	74056813	74056813	T	C	Splice_Site	p.N54_splice	1
GFM2	LIHC	chr5	74037421	74037421	T	C	Missense_Mutation	p.D288G	1
GFM2	SKCM	chr5	74043529	74043529	T	G	Missense_Mutation	p.K199T	1
GFM2	THYM	chr5	74017565	74017565	G	T	Missense_Mutation	p.T752N	1
GFM2	LUAD	chr5	74059507	74059507	T	A	Missense_Mutation	p.N21Y	1
GFM2	STAD	chr5	74026118	74026118	G	A	Nonsense_Mutation	p.R565X	1
GFM2	CESC	chr5	74017486	74017486	C	G	Missense_Mutation	p.L778F	1
GFM2	READ	chr5	74026188	74026188	C	A	Missense_Mutation	p.E494D	1
GFM2	GBM	chr5	74041590	74041590	T	C	Silent		1
GFM2	SKCM	chr5	74034422	74034422	G	A	Silent	p.L375L	1
GFM2	THYM	chr5	74034165	74034165	G	T	Missense_Mutation	p.A433D	1
GFM2	BLCA	chr5	74021918	74021918	T	C	Missense_Mutation	p.H587R	1
GFM2	HNSC	chr5	74021841	74021841	C	G	Missense_Mutation	p.E613Q	1
GFM2	LUAD	chr5	74034397	74034397	C	T	Missense_Mutation	p.V384I	1
GFM2	KIRP	chr5	74018240	74018240	T	G	Missense_Mutation	p.K757N	1
GFM2	SARC	chr5	74021779	74021779	G	T	Missense_Mutation		1
GFM2	BLCA	chr5	74035829	74035829	C	G	Missense_Mutation		1
GFM2	HNSC	chr5	74017519	74017519	A	G	Silent		1
GFM2	SKCM	chr5	74032630	74032631	-	A	Frame_Shift_Ins	p.A501fs	1
GFM2	UCEC	chr5	74026184	74026184	T	C	Missense_Mutation	p.I575V	1
GFM2	BLCA	chr5	74021829	74021829	C	G	Missense_Mutation	p.E617Q	1
GFM2	MESO	chr5	74028877	74028877	C	A	Missense_Mutation		1
GFM2	STAD	chr5	74026094	74026094	G	A	Missense_Mutation	p.R573C	1
GFM2	COAD	chr5	74018216	74018216	T	C	Silent	p.L733L	1
GFM2	KIRP	chr5	74026107	74026107	G	T	Silent	p.I600I	1
GFM2	LIHC	chr5	74028915	74028915	G	T	Missense_Mutation		1
GFM2	BLCA	chr5	74021918	74021918	T	C	Missense_Mutation		1
GFM2	HNSC	chr5	74041581	74041581	C	G	Missense_Mutation		1
GFM2	STAD	chr5	74034392	74034392	A	-	Frame_Shift_Del		1

Copy number variation (CNV) of GFM2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across GFM2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
94094	N/A	AI361381	GFM2	chr5	74016943	-	HEXB	chr5	74016572	-
64996	N/A	CN357114	GFM2	chr5	74056752	-	SPAG6	chr10	22699957	+
103155	N/A	CF140394	KCNE1	chr21	35881773	+	GFM2	chr5	74017084	+
103155	OV	TCGA-09-2056	PRRC2C	chr1	171454874	+	GFM2	chr5	74059591	-
103155	N/A	EC500948	SACM1L	chr3	45737321	+	GFM2	chr5	74053797	-
103159	N/A	FN136978	ZNRF2	chr7	30406672	-	GFM2	chr5	74033281	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	GFM2	0.000366132143230422	0.0099
SARC	GFM2	0.0163960819189081	0.43
TGCT	GFM2	9.91292601072048e-06	0.00028

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	GFM2	0.00519951446449643	0.17
LAML	GFM2	0.0324215447710238	0.97
BRCA	GFM2	0.0164851724674861	0.53
SARC	GFM2	0.0303033090207273	0.94

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0023264	Leigh Disease	4	CLINGEN
C1838951	LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY	4	CLINGEN
C1850597	Leigh Syndrome Due To Mitochondrial Complex II Deficiency	4	CLINGEN
C1850598	Leigh Syndrome due to Mitochondrial Complex III Deficiency	4	CLINGEN
C1850599	Leigh Syndrome due to Mitochondrial Complex IV Deficiency	4	CLINGEN
C1850600	Leigh Syndrome due to Mitochondrial Complex V Deficiency	4	CLINGEN
C2931891	Necrotizing encephalopathy, infantile subacute, of Leigh	4	CLINGEN
C0003886	Arthrogryposis	1	GENOMICS_ENGLAND