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Translation Factor: MPV17L2 (NCBI Gene ID:84769) |
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 Gene Summary |
| Gene Information | Gene Name: MPV17L2 | Gene ID: 84769 | Gene Symbol | MPV17L2 | Gene ID | 84769 |
| Gene Name | MPV17 mitochondrial inner membrane protein like 2 | |
| Synonyms | FKSG24 | |
| Cytomap | 19p13.11 | |
| Type of Gene | protein-coding | |
| Description | mpv17-like protein 2MPV17 mitochondrial membrane protein-like 2 | |
| Modification date | 20200313 | |
| UniProtAcc | Q567V2 | |
| Child GO biological process term(s) under GO:0006412 |
| GO ID | GO term |
| GO:0006417 | Regulation of translation |
| GO:0032543 | Mitochondrial translation |
| GO:0005840 | Ribosome |
| GO:0045727 | Positive regulation of translation |
| GO:0006412 | Translation |
| Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Inferred gene age of translation factor. |
| Gene | Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25 |
| MPV17L2 | (733 - 1119.25] |
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| We searched PubMed using 'MPV17L2[title] AND translation [title] AND human.' |
| Gene | Title | PMID |
| MPV17L2 | . | . |
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| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. For more annotations, please visit our ExonSkipDB. |
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| Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ENST | Exon skip start (DNA) | Exon Skip end (DNA) | ORF |
| ENST00000599612 | 18305586 | 18305663 | Frame-shift |
| Exon skipping position in the amino acid sequence. |
| ENST | Exon skip start (DNA) | Exon Skip end (DNA) | Len(transcript seq) | Exon skip start (mRNA) | Exon Skip end (mRNA) | Len(amino acid seq) | Exon skip start (AA) | Exon Skip end (AA) |
| Potentially (partially) lost protein functional features of UniProt. |
| UniProtAcc | Exon skip start (AA) | Exon Skip end (AA) | Function feature start (AA) | Function feature end (AA) | Functional feature type | Functional feature desc. |
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| Gene expression level across TCGA pancancer |
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| Gene expression level across GTEx pantissue |
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| Expression level of gene isoforms across TCGA pancancer |
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| Expression level of gene isoforms across GTEx pantissue |
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| Cancer(tissue) type-specific expression level of Translation factor using z-score distriution |
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| Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples) |
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| Cancer type | Translation factor | FC | adj.pval |
| LUSC | MPV17L2 | -7.28891386258943 | 1.79996309233889e-05 |
| KIRC | MPV17L2 | 2.29157993709736 | 4.20847844679104e-11 |
| KICH | MPV17L2 | 2.33130133650876 | 8.34465026855468e-07 |
| BRCA | MPV17L2 | -5.72458359109457 | 9.21592936568123e-22 |
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| Translation factor expression regulation through miRNA binding |
| Cancer type | Gene | miRNA | TargetScan binding score (Context++ score percentile) | Coefficient | Pvalue |
| Translation factor expression regulation through methylation in the promoter of Translation factor |
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| Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
| Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation) |
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| Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
| Translation factor expression regulation through copy number variation of Translation factor |
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| Cancer type | Gene | Coefficient | Pvalue |
| BLCA | MPV17L2 | 0.072656037 | 0.003454269 |
| SKCM | MPV17L2 | -0.077067799 | 0.024989455 |
| THYM | MPV17L2 | 0.039269484 | 0.028511727 |
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| Strongly correlated genes belong to cellular important gene groups with MPV17L2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green) |
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| Cancer type | Gene group | Translation factor | Correlated gene | Coefficient | Pvalue |
| KICH | Cell metabolism gene | MPV17L2 | PTGES2 | 0.809112824 | 2.93E-22 |
| KICH | Cell metabolism gene | MPV17L2 | POLR2E | 0.811040336 | 1.95E-22 |
| KICH | Cell metabolism gene | MPV17L2 | BSG | 0.814493688 | 9.32E-23 |
| KICH | Cell metabolism gene | MPV17L2 | HAGHL | 0.82390202 | 1.14E-23 |
| KICH | Cell metabolism gene | MPV17L2 | TOMM40 | 0.846980389 | 3.76E-26 |
| KICH | Cell metabolism gene | MPV17L2 | ALDOA | 0.854951436 | 4.17E-27 |
| KICH | IUPHAR | MPV17L2 | PTGES2 | 0.809112824 | 2.93E-22 |
| KICH | IUPHAR | MPV17L2 | BSG | 0.814493688 | 9.32E-23 |
| THYM | Cell metabolism gene | MPV17L2 | PFDN2 | 0.819434251 | 8.72E-31 |
| UCS | Cell metabolism gene | MPV17L2 | PFDN2 | 0.819434251 | 8.72E-31 |
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| Protein 3D structure Visit iCn3D. |
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| Protein-protein interaction networks * Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
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| Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
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 * Edge colors based on TCGA cancer types. |
| * Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P)) |
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| Cancer type | Translation factor | Interacting protein coding gene | FC | adj.pval |
| KIRC | MPV17L2 | MRM1 | -1.0752967360736 | 0.000369980864421695 |
| LUAD | MPV17L2 | TOMM20 | -3.2598483828594 | 0.000414758264772899 |
| COAD | MPV17L2 | MRM1 | 1.23939201416786 | 0.000934779644012452 |
| HNSC | MPV17L2 | MPV17 | -1.03077377754481 | 0.00106627625814326 |
| LIHC | MPV17L2 | DDX28 | -1.80556919949378 | 0.00268062725366399 |
| CHOL | MPV17L2 | MPV17 | -2.61711748156294 | 0.00390625 |
| ESCA | MPV17L2 | MRM1 | -1.22344393858478 | 0.013671875 |
| LIHC | MPV17L2 | FASTKD2 | -2.17426498508978 | 0.0264015241133303 |
| STAD | MPV17L2 | DDX28 | -1.74473313280693 | 0.0309218638576567 |
| KIRP | MPV17L2 | DDX28 | 1.78729156338422 | 0.0309218638576567 |
| HNSC | MPV17L2 | MRM1 | -1.32565285334556 | 0.0341586761198869 |
| HNSC | MPV17L2 | FASTKD2 | -1.72219345188751 | 0.0410440647583528 |
| BLCA | MPV17L2 | MPV17 | -1.69405931030761 | 0.0493659973144531 |
| LUAD | MPV17L2 | MRM1 | -2.80386903975905 | 1.0542655358657e-09 |
| BRCA | MPV17L2 | MPV17 | -1.9005562275398 | 1.5083061390423e-08 |
| LIHC | MPV17L2 | TOMM20 | -5.32977279271308 | 2.71217975233539e-06 |
| LUSC | MPV17L2 | MRM1 | -4.21236979058036 | 2.79558697199975e-08 |
| HNSC | MPV17L2 | MPV17L | 3.22565937599563 | 3.78557160729543e-07 |
| KICH | MPV17L2 | C19orf70 | 1.23829835979423 | 3.814697265625e-05 |
| BRCA | MPV17L2 | FASTKD2 | -1.95659368089906 | 4.12639478109604e-08 |
| KICH | MPV17L2 | DDX28 | 2.68166675030171 | 4.54187393188476e-05 |
| Protein-protein interactors with this translation factor (BIOGRID-3.4.160) |
| PPI interactors with MPV17L2 |
| PCNT, Nup188, Fbxo21, TRDN, DDX39A, |
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| Clinically associated variants from ClinVar. |
| Gene | Chr | Position | RefSeq | VarSeq | RefSeeq | VarType | Pathogenic | Disease | VarInfo |
| MPV17L2 | chr19 | 18304123 | G | A | single_nucleotide_variant | not_provided | not_provided | SO:0001583|missense_variant | SO:0001583|missense_variant |
| MPV17L2 | chr19 | 18304700 | A | G | single_nucleotide_variant | Benign | not_provided | SO:0001583|missense_variant | SO:0001583|missense_variant |
| nsSNVs with sample frequency (size of circle) from TCGA 33 cancers. |
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| SNVs and Indels |
| Gene | Cancer type | Chromosome | Start | End | RefSeeq | MutSeq | Mutation type | AAchange | # samples |
| Copy number variation (CNV) of MPV17L2 * Click on the image to open the original image in a new window. |
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| Fusion gene breakpoints (product of the structural variants (SVs)) across MPV17L2 * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion genes with this translation factor from FusionGDB2.0. |
| FusionGDB2 ID | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| N/A | EC560013 | RP11-106M3.2 | chr15 | 72626270 | - | MPV17L2 | chr19 | 18307330 | + |
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| Kaplan-Meier plots with logrank tests of overall survival (OS) |
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| Cancer type | Translation factor | Coefficent | Hazard ratio | Wald test pval | Likelihool ratio pval | Logrank test pval | # samples |
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| Differential gene expression between female and male. (Wilcoxon test, pval<0.05) |
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| Cancer type | Translation factor | pval | adj.p |
| KIRP | MPV17L2 | 0.00151555513562824 | 0.042 |
| LIHC | MPV17L2 | 0.00350162346917281 | 0.095 |
| TGCT | MPV17L2 | 0.00527665423214822 | 0.14 |
| SKCM | MPV17L2 | 0.0217194897080628 | 0.54 |
| HNSC | MPV17L2 | 0.037638875928619 | 0.9 |
| ESCA | MPV17L2 | 0.0393795884774683 | 0.91 |
| CHOL | MPV17L2 | 0.048835457740859 | 1 |
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| Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05) |
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| Cancer type | Translation factor | pval | adj.p |
| LUSC | MPV17L2 | 0.0153710479413671 | 0.48 |
| KIRC | MPV17L2 | 0.0321587233229172 | 0.96 |
| LGG | MPV17L2 | 0.0106482886812778 | 0.34 |
| PAAD | MPV17L2 | 0.00243800594880065 | 0.08 |
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| Drugs targeting genes involved in this translation factor. (DrugBank Version 5.1.8 2021-05-08) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| Diseases associated with this translation factor. (DisGeNet 4.0) |
| Disease ID | Disease Name | # PubMeds | Disease source |
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