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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MPV17L2 (NCBI Gene ID:84769)

Gene Summary

Gene Summary

Gene Information	Gene Name: MPV17L2
	Gene ID: 84769
	Gene Symbol	MPV17L2
	Gene ID	84769
	Gene Name	MPV17 mitochondrial inner membrane protein like 2
	Synonyms	FKSG24
	Cytomap	19p13.11
	Type of Gene	protein-coding
	Description	mpv17-like protein 2MPV17 mitochondrial membrane protein-like 2
	Modification date	20200313
	UniProtAcc	Q567V2

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0045727	Positive regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MPV17L2	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'MPV17L2[title] AND translation [title] AND human.'

Gene	Title	PMID
MPV17L2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000599612	18305586	18305663	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUSC	MPV17L2	-7.28891386258943	1.79996309233889e-05
KIRC	MPV17L2	2.29157993709736	4.20847844679104e-11
KICH	MPV17L2	2.33130133650876	8.34465026855468e-07
BRCA	MPV17L2	-5.72458359109457	9.21592936568123e-22

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
BLCA	MPV17L2	0.072656037	0.003454269
SKCM	MPV17L2	-0.077067799	0.024989455
THYM	MPV17L2	0.039269484	0.028511727

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MPV17L2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
KICH	Cell metabolism gene	MPV17L2	PTGES2	0.809112824	2.93E-22
KICH	Cell metabolism gene	MPV17L2	POLR2E	0.811040336	1.95E-22
KICH	Cell metabolism gene	MPV17L2	BSG	0.814493688	9.32E-23
KICH	Cell metabolism gene	MPV17L2	HAGHL	0.82390202	1.14E-23
KICH	Cell metabolism gene	MPV17L2	TOMM40	0.846980389	3.76E-26
KICH	Cell metabolism gene	MPV17L2	ALDOA	0.854951436	4.17E-27
KICH	IUPHAR	MPV17L2	PTGES2	0.809112824	2.93E-22
KICH	IUPHAR	MPV17L2	BSG	0.814493688	9.32E-23
THYM	Cell metabolism gene	MPV17L2	PFDN2	0.819434251	8.72E-31
UCS	Cell metabolism gene	MPV17L2	PFDN2	0.819434251	8.72E-31

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRC	MPV17L2	MRM1	-1.0752967360736	0.000369980864421695
LUAD	MPV17L2	TOMM20	-3.2598483828594	0.000414758264772899
COAD	MPV17L2	MRM1	1.23939201416786	0.000934779644012452
HNSC	MPV17L2	MPV17	-1.03077377754481	0.00106627625814326
LIHC	MPV17L2	DDX28	-1.80556919949378	0.00268062725366399
CHOL	MPV17L2	MPV17	-2.61711748156294	0.00390625
ESCA	MPV17L2	MRM1	-1.22344393858478	0.013671875
LIHC	MPV17L2	FASTKD2	-2.17426498508978	0.0264015241133303
KIRP	MPV17L2	DDX28	1.78729156338422	0.0309218638576567
STAD	MPV17L2	DDX28	-1.74473313280693	0.0309218638576567
HNSC	MPV17L2	MRM1	-1.32565285334556	0.0341586761198869
HNSC	MPV17L2	FASTKD2	-1.72219345188751	0.0410440647583528
BLCA	MPV17L2	MPV17	-1.69405931030761	0.0493659973144531
LUAD	MPV17L2	MRM1	-2.80386903975905	1.0542655358657e-09
BRCA	MPV17L2	MPV17	-1.9005562275398	1.5083061390423e-08
LIHC	MPV17L2	TOMM20	-5.32977279271308	2.71217975233539e-06
LUSC	MPV17L2	MRM1	-4.21236979058036	2.79558697199975e-08
HNSC	MPV17L2	MPV17L	3.22565937599563	3.78557160729543e-07
KICH	MPV17L2	C19orf70	1.23829835979423	3.814697265625e-05
BRCA	MPV17L2	FASTKD2	-1.95659368089906	4.12639478109604e-08
KICH	MPV17L2	DDX28	2.68166675030171	4.54187393188476e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MPV17L2

PCNT, Nup188, Fbxo21, TRDN, DDX39A,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MPV17L2	chr19	18304123	G	A	single_nucleotide_variant	not_provided	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
MPV17L2	chr19	18304700	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MPV17L2	KIRC	chr19	18305818	18305819	-	C	Frame_Shift_Ins	p.VP162fs	7
MPV17L2	CESC	chr19	18305824	18305824	C	T	Silent		4
MPV17L2	BRCA	chr19	18304729	18304729	G	A	Silent	p.L81	2
MPV17L2	UCEC	chr19	18306903	18306903	T	C	Silent	p.P130	2
MPV17L2	LUAD	chr19	18305818	18305819	-	C	Frame_Shift_Ins	p.V162fs	2
MPV17L2	SKCM	chr19	18304781	18304781	C	T	Missense_Mutation	p.L99F	2
MPV17L2	SKCM	chr19	18304780	18304780	C	T	Silent	p.V98V	2
MPV17L2	ESCA	chr19	18305819	18305819	C	-	Frame_Shift_Del	p.P164fs	2
MPV17L2	STAD	chr19	18304698	18304698	G	A	Missense_Mutation		2
MPV17L2	PAAD	chr19	18305857	18305857	G	A	Silent		2
MPV17L2	STAD	chr19	18304698	18304698	G	A	Missense_Mutation	p.S71N	2
MPV17L2	PAAD	chr19	18305800	18305800	C	T	Silent	p.F156F	2
MPV17L2	PAAD	chr19	18305857	18305857	G	A	Silent	p.T175T	2
MPV17L2	BLCA	chr19	18305832	18305832	G	C	Missense_Mutation	p.R167P	2
MPV17L2	PAAD	chr19	18306860	18306860	G	A	Missense_Mutation	p.D206N	2
MPV17L2	BLCA	chr19	18304802	18304802	C	T	Nonsense_Mutation	p.Q106*	2
MPV17L2	UCEC	chr19	18305800	18305800	C	T	Missense_Mutation	p.R67C	2
MPV17L2	LIHC	chr19	18306852	18306852	C	-	Frame_Shift_Del	p.T203fs	1
MPV17L2	PAAD	chr19	18305857	18305857	G	A	Missense_Mutation	p.A150T	1
MPV17L2	LUAD	chr19	18305841	18305841	A	T	Missense_Mutation	p.Y170F	1
MPV17L2	READ	chr19	18305846	18305846	A	G	Missense_Mutation	p.N172D	1
MPV17L2	LUAD	chr19	18305825	18305825	C	G	Missense_Mutation	p.Q165E	1
MPV17L2	SARC	chr19	18307207	18307207	C	A	Missense_Mutation	p.P296T	1
MPV17L2	CESC	chr19	18307151	18307151	C	T	Missense_Mutation	p.S304F	1
MPV17L2	ESCA	chr19	18305819	18305819	C	-	Frame_Shift_Del	p.Q165fs	1
MPV17L2	LUSC	chr19	18304774	18304774	A	G	Silent	p.P32P	1
MPV17L2	PAAD	chr19	18305800	18305800	C	T	Silent		1
MPV17L2	BLCA	chr19	18305832	18305832	G	C	Missense_Mutation		1
MPV17L2	BLCA	chr19	18305642	18305642	G	T	Missense_Mutation		1
MPV17L2	LIHC	chr19	18305819	18305819	C	-	Frame_Shift_Del	p.V162fs	1
MPV17L2	BLCA	chr19	18304700	18304700	A	G	Missense_Mutation		1
MPV17L2	STAD	chr19	18305819	18305820	-	C	Frame_Shift_Ins	p.A73fs	1
MPV17L2	LIHC	chr19	18306856	18306856	A	C	Silent	p.R204R	1
MPV17L2	THCA	chr19	18305894	18305894	C	A	Silent		1
MPV17L2	LIHC	chr19	18304706	18304706	C	-	Frame_Shift_Del	p.P74fs	1
MPV17L2	BLCA	chr19	18305642	18305642	G	T	Missense_Mutation	p.E138D	1
MPV17L2	THYM	chr19	18304774	18304774	A	G	Silent	p.P96P	1
MPV17L2	LIHC	chr19	18306827	18306827	C	-	Frame_Shift_Del	p.P196fs	1
MPV17L2	PAAD	chr19	18305800	18305800	C	T	Missense_Mutation	p.R131C	1

Copy number variation (CNV) of MPV17L2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MPV17L2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
	N/A	EC560013	RP11-106M3.2	chr15	72626270	-	MPV17L2	chr19	18307330	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	MPV17L2	0.00151555513562824	0.042
LIHC	MPV17L2	0.00350162346917281	0.095
TGCT	MPV17L2	0.00527665423214822	0.14
SKCM	MPV17L2	0.0217194897080628	0.54
HNSC	MPV17L2	0.037638875928619	0.9
ESCA	MPV17L2	0.0393795884774683	0.91
CHOL	MPV17L2	0.048835457740859	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	MPV17L2	0.0153710479413671	0.48
KIRC	MPV17L2	0.0321587233229172	0.96
LGG	MPV17L2	0.0106482886812778	0.34
PAAD	MPV17L2	0.00243800594880065	0.08

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source