Home

Download

Statistics

Examples

Help

Contact

	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: UNK (NCBI Gene ID:85451)

Gene Summary

Gene Summary

Gene Information	Gene Name: UNK
	Gene ID: 85451
	Gene Symbol	UNK
	Gene ID	85451
	Gene Name	unk zinc finger
	Synonyms	UNKEMPT\|ZC3H5\|ZC3HDC5
	Cytomap	17q25.1
	Type of Gene	protein-coding
	Description	RING finger protein unkempt homologunk family zinc fingerunkempt family zinc fingerunkempt homologzinc finger CCCH domain-containing protein 5zinc finger CCCH-type containing 5zinc finger CCCH-type domain containing 5
	Modification date	20200313
	UniProtAcc	Q9C0B0

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
UNK	(733 - 1119.25]

Top

Translation Studies in PubMed

We searched PubMed using 'UNK[title] AND translation [title] AND human.'

Gene	Title	PMID
UNK	.	.

Top

Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000589666	73805840	73806050	In-frame
ENST00000589666	73809158	73809294	Frame-shift
ENST00000589666	73811249	73811334	Frame-shift
ENST00000589666	73814183	73814249	In-frame
ENST00000589666	73816000	73816189	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000589666	73805840	73806050	3942	215	424	810	35	104
ENST00000589666	73814183	73814249	3942	1416	1481	810	435	457
ENST00000589666	73816000	73816189	3942	1759	1947	810	549	612

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9C0B0	435	457	1	810	Chain	ID=PRO_0000213899;Note=RING finger protein unkempt homolog
Q9C0B0	549	612	1	810	Chain	ID=PRO_0000213899;Note=RING finger protein unkempt homolog
Q9C0B0	35	104	1	810	Chain	ID=PRO_0000213899;Note=RING finger protein unkempt homolog
Q9C0B0	35	104	84	113	Zinc finger	Note=C3H1-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00723
Q9C0B0	35	104	70	73	Compositional bias	Note=Poly-Arg

Top

Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUSC	UNK	-4.89776822588757	0.00150914863929232
UCEC	UNK	-3.49686114064022	0.015625
LIHC	UNK	-1.1038454198809	4.13231748257069e-06
KICH	UNK	2.2510409782136	5.38825988769531e-05

Top

Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
CHOL	UNK	hsa-miR-329-3p	70	0.311067193675889	0.0379882190422626
STAD	UNK	hsa-miR-106a-5p	73	0.318640416117571	0.00637328846362216
STAD	UNK	hsa-miR-17-5p	57	0.401202659369349	0.000478169657260595

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LAML	UNK	-0.057859888	0.011845266
COAD	UNK	-0.037822378	0.019698802

Top

Associated Genes

Strongly correlated genes belong to cellular important gene groups with UNK (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type

Gene group

Translation factor

Correlated gene

Coefficient

Pvalue

Top

Protein structure

Protein 3D structure
Visit iCn3D.

Top

Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
PRAD	UNK	KLRD1	2.03442102089676	0.000229829633746533
LIHC	UNK	MAPKAP1	-1.89093131792876	0.000728433344697673
BRCA	UNK	KLRD1	-1.40511744698895	0.00101021018872078
KIRP	UNK	CUL2	-1.43090309188456	0.00133262807503343
KIRP	UNK	UBE2B	1.369659542418	0.00207323394715786
CHOL	UNK	RPTOR	-2.34317187916664	0.00390625
ESCA	UNK	UBE2B	1.33447295018679	0.0068359375
KIRP	UNK	KLRD1	-1.96974937105077	0.00733334058895707
LIHC	UNK	USP9X	-1.42312809797393	0.00771475994620902
KICH	UNK	USP34	1.31264714319459	0.0255050659179687
PRAD	UNK	MAPKAP1	-3.00104855526642	0.0312569736289674
COAD	UNK	MAPKAP1	-4.40640658979864	0.0434664487838746
LUAD	UNK	MLST8	-1.0067433555627	1.03207777888518e-06
BRCA	UNK	MLST8	-1.86304443127359	1.06372586581501e-16
LUAD	UNK	KLRD1	-1.32592375353386	1.52668366875458e-07
LUSC	UNK	KLRD1	-2.78237668291254	2.29265779489349e-09
BRCA	UNK	UBE2B	-2.78289455468954	2.5689831302703e-06
LUAD	UNK	UBE2B	-2.21652053289095	3.10830002137103e-05
LUSC	UNK	HLA-G	-2.5391056716179	3.56628110751149e-06
LUSC	UNK	MLST8	-2.07059311474544	3.67421243367441e-07
LIHC	UNK	RPTOR	-4.36362270436135	6.64579404273587e-07
BRCA	UNK	CUL2	1.2367949455281	6.95849643705187e-07
THCA	UNK	USP34	-1.55795649769246	8.01947140171385e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with UNK

ATXN1, ATP6V1B2, ZFYVE19, UBA2, UBA52, YAP1, UBXN1, UFC1, UBE2A, UBE2B, TTLL12, PAICS, ATP6V1F, USP9X, TYMS, TRIP6, KIAA1598, UBE2D1, UCHL3, ZRANB2, SEC24A, VPS26A, UBE2C, S100A4, S100A9, DSTN, USP34, UBQLN1, SRXN1, STAM, IGBP1, SAV1, DPY30, HINT1, CALM2, CLTC, USMG5, ARF4, GDI2, MGST3, TUBB, HSPA4, CSDE1, PPP2CA, CDC42, EEF1A1, CSE1L, SERINC1, MATR3, MINOS1, ACTR3, RAB1A, KPNB1, VPS35, MTA2, TRA2B, RTN4, COPS3, C16orf72, CCT5, COX7B, TCP1, CALM1, LEPROTL1, COPA, RPL30, SPCS1, TMEM30A, RER1, COPB2, PDIA3, RPA3, RPS27L, HNRNPH1, HSPE1, ARF5, RAB5A, GNB2L1, COMMD6, PHB2, PDIA6, PCBP1, HNRNPU, CCT8, NUP155, PICALM, RAB14, CUL2, UGP2, ATP6V1H, YME1L1, YWHAG, KDM1A, GARS, PRRC2B, PTGES3, ITM2B, CBX3, RBFOX2, DDX5, SDCBP, HSP90AB1, ARF1, VCL, LAPTM4A, ANP32E, COX7A2, ACTR2, PLK2, CKAP5, MKLN1, PNRC1, IPO7, PRDX3, FAM49B, LDHA, LIMCH1, CCT4, CBX5, YBX1, TNPO3, C14orf2, PSMB1, PARK7, KRAS, GGPS1, SRRM2, CAND1, TROVE2, ARPC2, CTNNB1, YWHAE, GHITM, ATP2A2, ACTB, HAT1, EIF4H, ACAT1, SPTBN1, COX5A, HDAC2, HSP90AA1, YWHAB, GDI1, ITGB1, UBA1, ATP6AP2, KPNA4, DHX15, FBXO11, EIF2S3, RRN3, PPP1CB, EIF4A1, MYEOV2, TXNL1, SLC38A2, LRRC58, SFPQ, HNRNPAB, NDFIP1, MSH6, ABCD3, YIPF4, RANBP9, UBE2G1, OCIAD1, H2AFY, TMPO, SAR1A, MCMBP, EIF4A2, PJA2, DNM1L, HUWE1, HERC1, OPA1, NCL, TFG, DYNC1H1, SUB1, YWHAZ, HSPD1, EEF2, ID3, CUL4A, RPL22L1, PLS3, DPYSL2, RAD21, IPO9, ARPC4, EIF3A, HN1, USP14, RPS3, EIF3E, BFAR, IP6K2, EMC6, H3F3B, EIF4G1, TOMM70A, ATP2B1, CTNNA1, NCBP1, TXN, SIN3A, MAPRE1, GLS, POLR2H, SF3B1, BIRC6, SKIV2L2, PDCD10, ATP5A1, CTSB, PPID, SNRPE, RAP1A, PSEN1, CHMP5, ATP5EP2, GFPT1, MTMR2, PDCD4, SDHC, MGA, WAC, OGDH, PKN2, RLIM, NUFIP2, TOP2A, SLC25A3, TXNL4A, NAP1L4, HNRNPL, EIF4G2, OGT, CSTF3, GPR85, SAFB, CNOT8, HSPA9, BCLAF1, HNRNPDL, EIF3H, RTCB, MARCH5, AP1G1, SF3B3, PPP6R3, XPO1, SLC38A1, PLAA, ARID1A, DHX36, BRD3, SLC4A7, ARL6IP1, PTP4A2, MCL1, CSNK2B, PPP1R15B, FOXP1, NFIB, DST, ATP5O, GLUD1, NUP98, ARHGAP5, SLC16A1, PTPRF, LUC7L3, CNIH4, STT3B, FAM13B, HIATL1, TOP2B, MED14, NPAT, KPNA6, TRAPPC8, ATPIF1, TSC22D1, HMGCR, GTF2H5, ABCB7, CALM3, POLR2A, MLLT6, YIPF6, TRIM14, RPTOR, DYNLRB1, BICD1, PLEKHA4, ESR1, AGO1, AGO2, ANKHD1-EIF4EBP3, ANKRD17, ATXN2, ATXN2L, CCDC85C, CEP85, CNOT1, CNOT10, CNOT11, CNOT2, CNOT3, CNOT6L, CNOT7, RQCD1, CPEB4, DVL3, EIF4ENIF1, FAM193A, FUBP3, HECA, HELZ, IARS2, KIAA0355, KIAA1671, LARP4B, LSM12, FAM195B, FAM195A, NBEA, OTUD4, PABPC1, PABPC4, PRRC2C, PUM1, PUM2, RC3H1, RC3H2, SIRT2, SMG1, SMG5, SMG7, TBKBP1, TDRD3, TNRC6A, TNRC6B, TNRC6C, TOP3B, UBAP2, UBAP2L, UNKL, UPF1, YTHDF2, ZC3H7A, ZNF598, CC2D1A, FMR1, IGF2BP2, MEX3A, RNF214, SMG8, SND1, TPM3, TPM4, USP10, YTHDF3, FXR2, MOB2, PRRC2A, YTHDF1, G3BP2, LSM14A, R3HDM1, SMG9, GPBP1, GPBP1L1, SYNJ1, TNKS1BP1, BAG3, BCAR1, CAPRIN1, G3BP1, RBMS1, TNIP1, ALMS1, GLE1, NRBF2, PPP1R13B, TMEM57, SH3RF1, SMAP2, nsp13ab, STAT1, GOLGA1, KRT8, SERBP1, SYNE3, MDFI, nsp14, CPEB1,

Top

Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
UNK	chr17	73813398	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
UNK	chr17	73814836	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
UNK	LUAD	chr17	73780812	73780812	G	A	Missense_Mutation	p.D27N	8
UNK	LUAD	chr17	73780814	73780814	C	A	Missense_Mutation	p.D27E	5
UNK	BLCA	chr17	73780818	73780818	G	A	Missense_Mutation	p.E29K	4
UNK	LIHC	chr17	73814802	73814802	C	-	Frame_Shift_Del	p.T560fs	3
UNK	UCEC	chr17	73805899	73805899	C	T	Nonsense_Mutation	p.Q131*	3
UNK	UCEC	chr17	73808348	73808348	G	A	Missense_Mutation	p.R233H	3
UNK	UCEC	chr17	73820373	73820373	C	A	Missense_Mutation	p.L846I	3
UNK	UCEC	chr17	73814820	73814820	G	A	Missense_Mutation	p.G566D	3
UNK	BLCA	chr17	73813469	73813469	C	T	Silent	p.S465S	3
UNK	PRAD	chr17	73780852	73780852	G	-	Frame_Shift_Del	p.W40fs	3
UNK	LUSC	chr17	73780747	73780747	G	A	Missense_Mutation	p.D23N	3
UNK	LIHC	chr17	73819525	73819525	C	T	Silent		3
UNK	UCEC	chr17	73818574	73818574	C	A	Missense_Mutation	p.N694K	3
UNK	LIHC	chr17	73808351	73808351	C	T	Missense_Mutation		3
UNK	CESC	chr17	73818677	73818677	G	C	Missense_Mutation		2
UNK	LIHC	chr17	73805856	73805856	C	A	Missense_Mutation		2
UNK	STAD	chr17	73819409	73819409	G	A	Missense_Mutation	p.E771K	2
UNK	SKCM	chr17	73808245	73808245	C	T	Missense_Mutation	p.R199C	2
UNK	CESC	chr17	73820430	73820430	G	C	Missense_Mutation		2
UNK	SARC	chr17	73820437	73820437	G	T	Missense_Mutation		2
UNK	COAD	chr17	73808347	73808347	C	T	Missense_Mutation	p.R157C	2
UNK	BLCA	chr17	73811302	73811302	G	T	Missense_Mutation	p.R386L	2
UNK	SARC	chr17	73812948	73812948	G	A	Silent		2
UNK	HNSC	chr17	73809222	73809222	G	A	Missense_Mutation	p.R305H	2
UNK	LUAD	chr17	73780814	73780814	C	T	Silent	p.D27D	2
UNK	THYM	chr17	73814808	73814808	C	T	Missense_Mutation		2
UNK	CESC	chr17	73819444	73819444	G	A	Silent		2
UNK	LIHC	chr17	73808234	73808234	G	-	Frame_Shift_Del	p.R195fs	2
UNK	LUAD	chr17	73818612	73818612	C	G	Missense_Mutation	p.S707C	2
UNK	CESC	chr17	73819469	73819469	G	A	Missense_Mutation	p.E791K	2
UNK	LIHC	chr17	73818612	73818612	C	-	Frame_Shift_Del	p.S707fs	2
UNK	UCEC	chr17	73808239	73808239	C	A	Missense_Mutation	p.H197N	2
UNK	CESC	chr17	73813417	73813417	G	A	Missense_Mutation	p.R448K	2
UNK	LIHC	chr17	73818616	73818616	G	-	Frame_Shift_Del	p.P708fs	2
UNK	READ	chr17	73814802	73814802	C	-	Frame_Shift_Del	p.T484fs	2
UNK	UCEC	chr17	73808286	73808286	G	A	Silent	p.S212	2
UNK	CESC	chr17	73818677	73818677	G	C	Missense_Mutation	p.E729Q	2
UNK	LIHC	chr17	73816156	73816156	T	-	Frame_Shift_Del	p.F678fs	2
UNK	COAD	chr17	73819525	73819525	C	T	Silent	p.S733S	2
UNK	UCEC	chr17	73814743	73814743	C	T	Silent	p.P540	2
UNK	CESC	chr17	73820444	73820444	G	C	Missense_Mutation	p.E869D	2
UNK	UCEC	chr17	73814765	73814765	A	G	Missense_Mutation	p.S548G	2
UNK	BRCA	chr17	73819525	73819525	C	T	Silent	p.S809	2
UNK	SKCM	chr17	73808245	73808245	C	T	Missense_Mutation	p.R123C	2
UNK	UCEC	chr17	73815803	73815803	G	A	Missense_Mutation	p.V605M	2
UNK	CESC	chr17	73813417	73813417	G	A	Missense_Mutation		2
UNK	STAD	chr17	73805975	73805975	G	A	Missense_Mutation		2
UNK	SKCM	chr17	73780853	73780853	G	A	Nonsense_Mutation	p.W40*	1
UNK	STAD	chr17	73814802	73814803	-	C	Frame_Shift_Ins	p.T560fs	1
UNK	KIRC	chr17	73816152	73816152	C	-	Frame_Shift_Del	p.N676fs	1
UNK	LIHC	chr17	73808617	73808617	G	A	Silent	p.A191A	1
UNK	LUSC	chr17	73780809	73780809	C	G	Missense_Mutation	p.P26_splice	1
UNK	SARC	chr17	73819501	73819501	G	T	Missense_Mutation		1
UNK	STAD	chr17	73805975	73805975	G	A	Missense_Mutation	p.G80D	1
UNK	CESC	chr17	73820430	73820430	G	C	Missense_Mutation	p.E865Q	1
UNK	BLCA	chr17	73811274	73811274	G	A	Missense_Mutation		1
UNK	HNSC	chr17	73809222	73809222	G	A	Missense_Mutation		1
UNK	SKCM	chr17	73805958	73805958	C	T	Silent	p.S74S	1
UNK	STAD	chr17	73819366	73819367	AG	-	Frame_Shift_Del	p.K756fs	1
UNK	KIRP	chr17	73818652	73818652	T	A	Silent	p.A644A	1
UNK	LIHC	chr17	73805856	73805856	C	A	Missense_Mutation	p.F40L	1
UNK	OV	chr17	73816190	73816190	G	C	Splice_Site	e14+1	1
UNK	LIHC	chr17	73814812	73814812	C	-	Frame_Shift_Del	p.S563fs	1
UNK	SARC	chr17	73819580	73819580	G	T	Missense_Mutation		1
UNK	STAD	chr17	73806045	73806045	C	T	Silent	p.G103G	1
UNK	COAD	chr17	73780976	73780976	C	T	Silent	p.P5P	1
UNK	LIHC	chr17	73820373	73820373	C	T	Missense_Mutation	p.L770F	1
UNK	BLCA	chr17	73812972	73812972	G	A	Silent		1
UNK	HNSC	chr17	73818688	73818688	A	T	Missense_Mutation		1
UNK	SKCM	chr17	73805988	73805988	C	T	Silent	p.Y84Y	1
UNK	STAD	chr17	73805973	73805973	C	T	Silent	p.D155D	1
UNK	SKCM	chr17	73808353	73808353	C	T	Missense_Mutation	p.P235S	1
UNK	STAD	chr17	73780920	73780922	AAT	-	In_Frame_Del	p.N64del	1
UNK	CESC	chr17	73816073	73816073	C	T	Missense_Mutation		1
UNK	KIRP	chr17	73809278	73809278	C	A	Silent		1
UNK	LIHC	chr17	73805893	73805893	T	C	Missense_Mutation	p.C53R	1
UNK	PRAD	chr17	73815809	73815809	G	A	Missense_Mutation	p.A607T	1
UNK	LIHC	chr17	73808287	73808287	A	-	Frame_Shift_Del	p.K213fs	1
UNK	STAD	chr17	73819366	73819367	AG	-	Frame_Shift_Del	p.680_680del	1
UNK	LIHC	chr17	73818612	73818612	C	-	Frame_Shift_Del	p.S631fs	1
UNK	HNSC	chr17	73813557	73813557	G	A	Missense_Mutation		1
UNK	LUAD	chr17	73820482	73820482	A	T	Missense_Mutation	p.H882L	1
UNK	SKCM	chr17	73812881	73812881	C	T	Missense_Mutation	p.S331F	1
UNK	STAD	chr17	73819405	73819405	C	T	Silent	p.G769G	1
UNK	SKCM	chr17	73809246	73809246	A	G	Missense_Mutation	p.Y313C	1
UNK	THYM	chr17	73780742	73780742	G	T	Missense_Mutation		1
UNK	CESC	chr17	73813463	73813463	G	T	Silent		1
UNK	KIRP	chr17	73808535	73808535	G	T	Splice_Site		1
UNK	LIHC	chr17	73805856	73805856	C	A	Missense_Mutation	p.F116L	1
UNK	PRAD	chr17	73809210	73809210	C	T	Missense_Mutation	p.P301L	1
UNK	LIHC	chr17	73808634	73808634	A	-	Frame_Shift_Del	p.E273fs	1
UNK	STAD	chr17	73805954	73805954	G	A	Missense_Mutation	p.R73Q	1
UNK	COAD	chr17	73809878	73809879	GT	-	Frame_Shift_Del	p.265_265del	1
UNK	LIHC	chr17	73811297	73811297	T	C	Silent	p.C308C	1
UNK	SKCM	chr17	73815766	73815766	G	A	Silent	p.E516E	1
UNK	STAD	chr17	73820394	73820394	C	T	Missense_Mutation	p.R853W	1
UNK	SKCM	chr17	73780868	73780868	C	T	Silent	p.F45F	1
UNK	LGG	chr17	73814838	73814838	G	A	Missense_Mutation	p.G572D	1
UNK	LIHC	chr17	73808634	73808634	A	-	Frame_Shift_Del	p.E197fs	1
UNK	LIHC	chr17	73808335	73808335	C	-	Frame_Shift_Del	p.P229fs	1
UNK	SARC	chr17	73819480	73819480	G	T	Missense_Mutation		1
UNK	STAD	chr17	73805973	73805973	C	T	Silent	p.D79D	1
UNK	UCEC	chr17	73809953	73809953	C	-	Frame_Shift_Del	p.H366fs	1
UNK	COAD	chr17	73812909	73812909	A	G	Silent	p.P340P	1
UNK	BLCA	chr17	73780919	73780919	G	C	Silent	p.L62L	1
UNK	HNSC	chr17	73818688	73818688	A	T	Missense_Mutation	p.E732D	1
UNK	SKCM	chr17	73805988	73805988	C	T	Silent	p.Y160Y	1
UNK	SKCM	chr17	73818632	73818632	T	G	Missense_Mutation	p.F714V	1
UNK	STAD	chr17	73808347	73808347	C	T	Missense_Mutation	p.R233C	1
UNK	SKCM	chr17	73812881	73812881	C	T	Missense_Mutation	p.S407F	1
UNK	THYM	chr17	73819418	73819418	C	T	Silent	p.L698L	1
UNK	LGG	chr17	73808617	73808617	G	A	Silent	p.A267A	1
UNK	PRAD	chr17	73811288	73811288	G	T	Silent	p.S381S	1
UNK	COAD	chr17	73812972	73812972	G	A	Silent	p.P361P	1
UNK	LIHC	chr17	73809274	73809274	C	-	Frame_Shift_Del	p.S322fs	1
UNK	SARC	chr17	73812948	73812948	G	A	Silent	p.S429S	1
UNK	STAD	chr17	73805997	73805997	C	T	Silent	p.D87D	1
UNK	HNSC	chr17	73813557	73813557	G	A	Missense_Mutation	p.E495K	1
UNK	LUAD	chr17	73780837	73780837	C	A	Missense_Mutation	p.T35N	1
UNK	SKCM	chr17	73818610	73818610	C	T	Silent	p.F706F	1
UNK	SKCM	chr17	73818665	73818665	C	T	Nonsense_Mutation	p.R725*	1
UNK	STAD	chr17	73805997	73805997	C	T	Silent	p.D163D	1
UNK	SKCM	chr17	73818612	73818612	C	T	Missense_Mutation	p.S707F	1
UNK	THYM	chr17	73814808	73814808	C	T	Missense_Mutation	p.P486L	1
UNK	LGG	chr17	73780866	73780866	T	-	Frame_Shift_Del	p.F45fs	1
UNK	COAD	chr17	73816026	73816026	A	G	Silent	p.A558A	1
UNK	LIHC	chr17	73811298	73811298	C	-	Frame_Shift_Del	p.P385fs	1
UNK	SARC	chr17	73814874	73814874	G	T	Missense_Mutation	p.S584I	1
UNK	STAD	chr17	73820418	73820418	G	A	Missense_Mutation	p.A785T	1
UNK	BLCA	chr17	73814729	73814729	C	T	Silent	p.L536L	1
UNK	KIRC	chr17	73816152	73816152	C	-	Frame_Shift_Del	p.N600fs	1
UNK	LUAD	chr17	73814801	73814802	-	C	Frame_Shift_Ins	p.P560fs	1
UNK	SKCM	chr17	73813487	73813487	C	T	Silent	p.N471N	1
UNK	SKCM	chr17	73818663	73818663	C	G	Missense_Mutation	p.A724G	1
UNK	STAD	chr17	73805920	73805920	T	C	Missense_Mutation	p.F138L	1
UNK	SKCM	chr17	73813549	73813549	C	T	Missense_Mutation	p.P492L	1
UNK	THYM	chr17	73816190	73816190	G	T	Splice_Site	.	1
UNK	LGG	chr17	73808617	73808617	G	A	Silent		1
UNK	SARC	chr17	73809265	73809265	G	T	Silent		1
UNK	ACC	chr17	73806016	73806016	G	A	Missense_Mutation	p.D170N	1
UNK	LIHC	chr17	73813564	73813564	A	-	Frame_Shift_Del	p.E497fs	1
UNK	SKCM	chr17	73815826	73815826	C	T	Silent	p.F536F	1
UNK	STAD	chr17	73814733	73814733	G	A	Missense_Mutation	p.G537D	1
UNK	BLCA	chr17	73812972	73812972	G	A	Silent	p.P437P	1
UNK	KIRC	chr17	73814848	73814848	A	C	Silent	p.A499A	1
UNK	SKCM	chr17	73780856	73780856	G	A	Silent	p.G41G	1
UNK	SKCM	chr17	73815826	73815826	C	T	Silent	p.F612F	1
UNK	STAD	chr17	73805954	73805954	G	A	Missense_Mutation	p.R149Q	1
UNK	LIHC	chr17	73808302	73808302	A	-	Frame_Shift_Del	p.K218fs	1
UNK	SARC	chr17	73814852	73814852	G	T	Missense_Mutation		1
UNK	SKCM	chr17	73815766	73815766	G	A	Splice_Site	p.E592_splice	1
UNK	UCEC	chr17	73808203	73808203	C	T	Silent	p.L185L	1
UNK	LGG	chr17	73780751	73780751	C	A	Missense_Mutation		1
UNK	BLCA	chr17	73811302	73811302	G	T	Missense_Mutation		1
UNK	COAD	chr17	73820417	73820417	C	T	Silent	p.H784H	1
UNK	LIHC	chr17	73809894	73809894	A	C	Missense_Mutation		1
UNK	SKCM	chr17	73818612	73818612	C	T	Missense_Mutation	p.S631F	1
UNK	STAD	chr17	73818727	73818727	G	A	Silent	p.K745K	1
UNK	KIRC	chr17	73814863	73814863	C	T	Silent	p.F580F	1
UNK	LUSC	chr17	73780870	73780870	C	G	Missense_Mutation	p.S46W	1
UNK	SKCM	chr17	73805957	73805957	C	G	Missense_Mutation	p.S150C	1
UNK	STAD	chr17	73813510	73813510	G	T	Missense_Mutation	p.G479V	1
UNK	LIHC	chr17	73809206	73809206	C	-	Frame_Shift_Del	p.P301fs	1
UNK	SARC	chr17	73814874	73814874	G	T	Missense_Mutation		1
UNK	SKCM	chr17	73808213	73808213	C	T	Missense_Mutation	p.T188I	1
UNK	UCEC	chr17	73814743	73814743	C	T	Silent	p.P540P	1
UNK	CESC	chr17	73819469	73819469	G	A	Missense_Mutation		1
UNK	BLCA	chr17	73813469	73813469	C	T	Silent		1
UNK	DLBC	chr17	73780999	73780999	C	T	Missense_Mutation	p.S13F	1
UNK	LUAD	chr17	73813435	73813435	G	C	Missense_Mutation	p.S454T	1
UNK	STAD	chr17	73805975	73805975	G	A	Missense_Mutation	p.G156D	1
UNK	KIRC	chr17	73814848	73814848	A	C	Silent	p.A575A	1
UNK	LUSC	chr17	73814897	73814897	G	A	Missense_Mutation	p.E592_splice	1
UNK	SKCM	chr17	73805958	73805958	C	T	Silent	p.S150S	1
UNK	STAD	chr17	73806045	73806045	C	T	Silent	p.G179G	1
UNK	LIHC	chr17	73814787	73814787	C	-	Frame_Shift_Del	p.S556fs	1
UNK	SARC	chr17	73816122	73816122	G	T	Missense_Mutation		1
UNK	CESC	chr17	73816073	73816073	C	T	Missense_Mutation	p.S650L	1
UNK	BLCA	chr17	73780919	73780919	G	C	Silent		1
UNK	GBM	chr17	73780730	73780730	G	T	Missense_Mutation		1
UNK	LUAD	chr17	73813472	73813472	C	T	Silent	p.I466I	1
UNK	SKCM	chr17	73805957	73805957	C	G	Missense_Mutation	p.S74C	1
UNK	STAD	chr17	73820418	73820418	G	A	Missense_Mutation	p.A861T	1

Copy number variation (CNV) of UNK
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across UNK
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
82324	Non-Cancer	TCGA-BR-6564-11A	ATF7	chr12	54019735	-	UNK	chr17	73805841	+
82324	STAD	TCGA-BR-A4PE	ITGB4	chr17	73732775	+	UNK	chr17	73820342	+
82324	STAD	TCGA-VQ-A928	ITGB4	chr17	73720862	+	UNK	chr17	73805840	+
82324	STAD	TCGA-CG-4305-01A	LLGL2	chr17	73560588	+	UNK	chr17	73787841	+
82324	N/A	EC543961	LLGL2	chr17	73535116	+	UNK	chr17	73796722	+
82324	UCEC	TCGA-EY-A3L3-01A	SAP30BP	chr17	73667943	+	UNK	chr17	73805841	+
82324	N/A	BE161616	SERP1	chr3	150261195	-	UNK	chr17	73787306	+
82324	BRCA	TCGA-C8-A273-01A	SLC16A5	chr17	73085399	+	UNK	chr17	73812851	+
96902	LUSC	TCGA-43-2581-01A	UNK	chr17	73781065	+	AVIL	chr12	58209842	-
100055	LUAD	TCGA-50-6673	UNK	chr17	73781065	+	B4GALNT2	chr17	47218608	+
100055	LUAD	TCGA-50-6673-01A	UNK	chr17	73781064	+	B4GALNT2	chr17	47218608	+
100055	LUAD	TCGA-50-6673-01A	UNK	chr17	73781065	+	B4GALNT2	chr17	47218609	+
96902	UCEC	TCGA-EY-A3L3	UNK	chr17	73781065	+	C1QTNF1	chr17	77040036	+
96902	UCEC	TCGA-EY-A3L3-01A	UNK	chr17	73781065	+	C1QTNF1	chr17	77040037	+
96902	UCEC	TCGA-EY-A3L3-01A	UNK	chr17	73781065	+	C1QTNF1	chr17	77042637	+
101956	N/A	AI088740	UNK	chr17	73810569	-	CBX5	chr12	54624730	+
102627	LUSC	TCGA-43-3920	UNK	chr17	73781065	+	DPYD	chr1	98058943	-
102627	LUSC	TCGA-43-3920-01A	UNK	chr17	73781065	+	DPYD	chr1	98039526	-
96902	STAD	TCGA-CD-5799-01A	UNK	chr17	73781065	+	DTYMK	chr2	242619734	-
96902	BRCA	TCGA-BH-A1ES-01A	UNK	chr17	73781065	+	ICAM2	chr17	62084095	-
99514	SARC	TCGA-DX-A8BL-01A	UNK	chr17	73781065	-	ITGB4	chr17	73736439	+
99514	UCEC	TCGA-BK-A139-01A	UNK	chr17	73781065	+	ITGB4	chr17	73744922	+
102568	ESCA	TCGA-L5-A8NI	UNK	chr17	73781065	+	KIAA0195	chr17	73467880	+
102568	ESCA	TCGA-L5-A8NI	UNK	chr17	73781065	+	KIAA0195	chr17	73467881	+
96902	UCEC	TCGA-D1-A16I-01A	UNK	chr17	73781065	+	MYO15B	chr17	73620851	+
96902	UCEC	TCGA-D1-A16I-01A	UNK	chr17	73781065	+	MYO15B	chr17	73621203	+
100174	LUAD	TCGA-86-7955-01A	UNK	chr17	73781065	+	NAF1	chr4	164085543	-
102907	KIRC	TCGA-BP-4983-01A	UNK	chr17	73781065	-	PRKCA	chr17	64492319	+
101064	N/A	AA744102	UNK	chr17	73799247	+	RAB2A	chr8	61430937	-
96902	UCEC	TCGA-KP-A3VZ-01A	UNK	chr17	73781065	+	RNF157	chr17	74169871	-
96902	STAD	TCGA-BR-7722-01A	UNK	chr17	73781065	+	SAP30BP	chr17	73689520	+
96902	SARC	TCGA-3B-A9HS-01A	UNK	chr17	73781065	+	SPOP	chr17	47700238	-
96902	LUAD	TCGA-50-5946-01A	UNK	chr17	73781065	+	ZNF266	chr19	9530894	-
96902	LUAD	TCGA-50-5946-01A	UNK	chr17	73781065	+	ZNF266	chr19	9544462	-

Top

Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

Top

Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	UNK	0.000249115979817804	0.007
KIRC	UNK	0.00666976189747391	0.18
BRCA	UNK	0.00855167738167897	0.22

Top

Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	UNK	0.0253548568965719	0.74
KIRP	UNK	0.00584400646156541	0.19
BRCA	UNK	0.00796496754289121	0.25
PRAD	UNK	0.0478189214345441	1
SKCM	UNK	0.0344283554338101	0.96
ESCA	UNK	0.0195391830722329	0.59
BLCA	UNK	0.0044750799850985	0.15

Top

Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source