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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MAPKAPK5 (NCBI Gene ID:8550)

Gene Summary

Gene Summary

Gene Information	Gene Name: MAPKAPK5
	Gene ID: 8550
	Gene Symbol	MAPKAPK5
	Gene ID	8550
	Gene Name	MAPK activated protein kinase 5
	Synonyms	MAPKAP-K5\|MK-5\|MK5\|PRAK
	Cytomap	12q24.12-q24.13
	Type of Gene	protein-coding
	Description	MAP kinase-activated protein kinase 5MAPKAP kinase 5MAPKAPK-5mitogen-activated protein kinase-activated protein kinase 5p38-regulated/activated protein kinase
	Modification date	20200313
	UniProtAcc	Q8IW41

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MAPKAPK5	GO:0006417	regulation of translation	21329882
Hgene	MAPKAPK5	GO:0007265	Ras protein signal transduction	17254968
Hgene	MAPKAPK5	GO:0046777	protein autophosphorylation	21329882
Hgene	MAPKAPK5	GO:0090400	stress-induced premature senescence	17254968

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'MAPKAPK5[title] AND translation [title] AND human.'

Gene	Title	PMID
MAPKAPK5	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000551404	112303053	112303127	Frame-shift
ENST00000551404	112303959	112304035	Frame-shift
ENST00000551404	112305375	112305473	Frame-shift
ENST00000551404	112306556	112306665	Frame-shift
ENST00000551404	112308074	112308164	In-frame
ENST00000551404	112318250	112318331	In-frame
ENST00000551404	112321384	112321572	Frame-shift
ENST00000551404	112323719	112323840	Frame-shift
ENST00000551404	112326688	112326810	Frame-shift
ENST00000551404	112327843	112327948	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000551404	112308074	112308164	1647	502	591	473	131	161
ENST00000551404	112318250	112318331	1647	688	768	473	193	220
ENST00000551404	112327843	112327948	1647	1331	1435	473	407	442

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q8IW41	193	220	1	473	Chain	ID=PRO_0000086296;Note=MAP kinase-activated protein kinase 5
Q8IW41	407	442	1	473	Chain	ID=PRO_0000086296;Note=MAP kinase-activated protein kinase 5
Q8IW41	131	161	1	473	Chain	ID=PRO_0000086296;Note=MAP kinase-activated protein kinase 5
Q8IW41	193	220	22	304	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q8IW41	131	161	22	304	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q8IW41	407	442	409	440	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8IW41	131	161	148	148	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159,ECO:0000255\|PROSITE-ProRule:PRU10027
Q8IW41	193	220	212	212	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12808055;Dbxref=PMID:12808055
Q8IW41	407	442	407	408	Alternative sequence	ID=VSP_011597;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:0000303\|PubMed:17974005;Dbxref=PMID:14702039,PMID:15489334,PMID:17974005
Q8IW41	193	220	212	212	Mutagenesis	Note=Mimicks phosphorylation state and displays a slightly higher protein kinase activity. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12808055;Dbxref=PMID:12808055

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	MAPKAPK5	-1.9009198752409	0.000358042351864552
KIRP	MAPKAPK5	-2.09446515689452	0.00779616041108966
PRAD	MAPKAPK5	-2.0610304486992	0.0160054188673
LIHC	MAPKAPK5	-1.54381786522309	1.89937725360959e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
SARC	MAPKAPK5	0.418937983	0.001819863
KICH	MAPKAPK5	0.088204911	0.003698325
ESCA	MAPKAPK5	0.145176071	0.020329862

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MAPKAPK5 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
TGCT	Cell metabolism gene	MAPKAPK5	NUP37	0.80863305	2.62E-37
UVM	Cell metabolism gene	MAPKAPK5	ALG10B	0.800608097	4.99E-19
UVM	Cell metabolism gene	MAPKAPK5	NUP107	0.809870844	9.43E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	MAPKAPK5	MAP2K3	-2.78256553991969	0.00016188295558095
KICH	MAPKAPK5	MYC	1.19194684236579	0.000329077243804932
PRAD	MAPKAPK5	MAP2K6	1.56020462725889	0.000512209556395587
LUAD	MAPKAPK5	HSPB1	-1.80049998348782	0.000895454784300369
HNSC	MAPKAPK5	MAPK4	1.63215588531605	0.000922890671972711
THCA	MAPKAPK5	MAP2K3	-2.34201871187663	0.00101209232175966
LIHC	MAPKAPK5	FOXO3	1.53551104941424	0.00126327311470459
LUAD	MAPKAPK5	MAP2K6	-1.48939097501243	0.00171473165568087
LUSC	MAPKAPK5	MYC	1.80145319254842	0.00250329335752618
KICH	MAPKAPK5	FOXO3	2.3552334994037	0.00308787822723389
CHOL	MAPKAPK5	MAP2K3	-1.4413121845416	0.00390625
STAD	MAPKAPK5	HSPB1	-1.72443393773291	0.00828406633809209
LUAD	MAPKAPK5	MAP2K3	-1.35652150991578	0.013228736909195
UCEC	MAPKAPK5	TP53	2.03295038376694	0.015625
LUSC	MAPKAPK5	FOXO3	-1.27881478220054	0.0174932185880974
STAD	MAPKAPK5	FOXO3	-1.49443762596336	0.0375871751457453
ESCA	MAPKAPK5	MAP2K3	1.23268012990233	0.0419921875
LUSC	MAPKAPK5	MAP2K3	-5.13769886340097	1.07831278943457e-05
BRCA	MAPKAPK5	MAPK14	-1.6928131480761	1.08867679255958e-06
PRAD	MAPKAPK5	MAPK14	1.20273850965986	2.06740855708439e-05
LIHC	MAPKAPK5	MAPK11	-2.04244177410399	2.35319665208461e-06
KIRC	MAPKAPK5	MYC	-7.57321539520974	3.45880777969452e-10
KIRC	MAPKAPK5	TP53	-1.43050981150632	4.58942580328929e-09
BRCA	MAPKAPK5	HSPB1	-1.44980343105922	4.97528468246305e-10
THCA	MAPKAPK5	TP53	-1.81960143635647	6.18215597921662e-07
KIRC	MAPKAPK5	HSPB1	-1.63515589515678	7.52485613123653e-05
THCA	MAPKAPK5	MAP2K6	1.19648085204418	7.74277447941537e-06
THCA	MAPKAPK5	MAPK11	-4.04478616286993	8.27580425414032e-05
LIHC	MAPKAPK5	MAP2K3	-1.72754488378517	8.74899637644469e-09
KIRP	MAPKAPK5	MYC	-5.46971831522856	9.0546440333128e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MAPKAPK5

HSPB1, HSPB2, MAPK6, MAPK14, RPL13, ZNF282, TAB1, Nedd4, MAPK4, MAPKAPK2, LSR, CDCA8, ZNF576, SRPK2, SRPK1, TP53, MAPK9, MAPK1, EIF4EBP1, MAPKAPK5, STK40, PARK7, CSK, Yap1, YAP1, CSNK1E, HSPD1, FASN, HMGB1, DDX39A, ZNF577, BCL7B,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MAPKAPK5	LIHC	chr12	112306591	112306591	G	-	Frame_Shift_Del	p.G108fs	3
MAPKAPK5	ESCA	chr12	112304016	112304016	G	A	Missense_Mutation	p.R56H	3
MAPKAPK5	CESC	chr12	112327921	112327921	G	C	Missense_Mutation		3
MAPKAPK5	UCEC	chr12	112308118	112308118	A	G	Missense_Mutation	p.H146R	3
MAPKAPK5	PRAD	chr12	112326400	112326400	C	G	Missense_Mutation	p.L360V	3
MAPKAPK5	UCEC	chr12	112306616	112306616	G	T	Missense_Mutation	p.S115I	2
MAPKAPK5	SKCM	chr12	112305454	112305454	C	T	Missense_Mutation	p.P89S	2
MAPKAPK5	LIHC	chr12	112321444	112321444	T	-	Frame_Shift_Del	p.P240fs	2
MAPKAPK5	UCEC	chr12	112323839	112323839	A	C	Missense_Mutation	p.K323T	2
MAPKAPK5	SKCM	chr12	112308966	112308966	T	C	Silent	p.P187P	2
MAPKAPK5	ESCA	chr12	112304016	112304016	G	A	Missense_Mutation		2
MAPKAPK5	UCEC	chr12	112330835	112330835	A	C	Missense_Mutation	p.E464D	2
MAPKAPK5	STAD	chr12	112305379	112305379	C	T	Missense_Mutation	p.R64C	2
MAPKAPK5	UVM	chr12	112330858	112330858	C	-	Frame_Shift_Del	p.S470fs	2
MAPKAPK5	STAD	chr12	112323793	112323793	G	A	Missense_Mutation	p.E308K	2
MAPKAPK5	LUAD	chr12	112326315	112326315	G	A	Silent	p.Q331Q	2
MAPKAPK5	UVM	chr12	112306587	112306587	G	-	Frame_Shift_Del	p.M105fs	2
MAPKAPK5	LIHC	chr12	112308091	112308091	G	A	Missense_Mutation		2
MAPKAPK5	STAD	chr12	112308145	112308145	T	-	Frame_Shift_Del	p.L155fs	2
MAPKAPK5	LUAD	chr12	112323825	112323825	G	T	Missense_Mutation	p.Q318H	2
MAPKAPK5	LIHC	chr12	112330837	112330837	A	T	Missense_Mutation		2
MAPKAPK5	LUAD	chr12	112323739	112323739	G	T	Nonsense_Mutation	p.E290*	2
MAPKAPK5	HNSC	chr12	112318261	112318261	C	T	Missense_Mutation	p.A197V	2
MAPKAPK5	PAAD	chr12	112326328	112326328	C	T	Nonsense_Mutation	p.Q336*	2
MAPKAPK5	LUAD	chr12	112326352	112326352	G	A	Missense_Mutation	p.D344N	2
MAPKAPK5	LGG	chr12	112321472	112321472	A	G	Missense_Mutation	p.I250V	2
MAPKAPK5	LIHC	chr12	112308091	112308091	G	A	Missense_Mutation	p.R137Q	2
MAPKAPK5	UCEC	chr12	112305415	112305415	G	T	Missense_Mutation	p.V76F	2
MAPKAPK5	LGG	chr12	112321472	112321472	A	G	Missense_Mutation		2
MAPKAPK5	BLCA	chr12	112326227	112326227	C	G	Missense_Mutation		1
MAPKAPK5	LUSC	chr12	112321495	112321495	G	C	Missense_Mutation	p.K257N	1
MAPKAPK5	LIHC	chr12	112321574	112321574	T	C	Splice_Site		1
MAPKAPK5	BLCA	chr12	112326395	112326395	C	T	Missense_Mutation		1
MAPKAPK5	ESCA	chr12	112321523	112321523	G	T	Nonsense_Mutation	p.E267*	1
MAPKAPK5	LUSC	chr12	112321523	112321523	G	A	Missense_Mutation	p.E267K	1
MAPKAPK5	LIHC	chr12	112306624	112306624	C	A	Silent		1
MAPKAPK5	BLCA	chr12	112303982	112303982	C	G	Missense_Mutation	p.Q45E	1
MAPKAPK5	LIHC	chr12	112326794	112326794	C	-	Frame_Shift_Del	p.L402fs	1
MAPKAPK5	MESO	chr12	112321417	112321417	C	A	Silent		1
MAPKAPK5	LIHC	chr12	112323800	112323800	T	C	Missense_Mutation		1
MAPKAPK5	BLCA	chr12	112323737	112323737	C	T	Missense_Mutation	p.P289L	1
MAPKAPK5	LIHC	chr12	112327901	112327901	G	-	Frame_Shift_Del	p.R425fs	1
MAPKAPK5	ESCA	chr12	112321523	112321523	G	T	Nonsense_Mutation	p.E267X	1
MAPKAPK5	MESO	chr12	112321452	112321452	C	A	Missense_Mutation		1
MAPKAPK5	LIHC	chr12	112305444	112305444	T	C	Silent		1
MAPKAPK5	BLCA	chr12	112326395	112326395	C	T	Missense_Mutation	p.P358L	1
MAPKAPK5	HNSC	chr12	112318261	112318261	C	T	Missense_Mutation		1
MAPKAPK5	MESO	chr12	112321507	112321507	C	A	Silent		1
MAPKAPK5	HNSC	chr12	112323725	112323725	T	A	Missense_Mutation		1
MAPKAPK5	OV	chr12	112318333	112318333	T	A	Splice_Site	p.K220_splice	1
MAPKAPK5	THYM	chr12	112330794	112330794	G	T	Missense_Mutation		1
MAPKAPK5	THYM	chr12	112308090	112308090	C	T	Missense_Mutation	p.R137W	1
MAPKAPK5	CESC	chr12	112327921	112327921	G	C	Missense_Mutation	p.D434H	1
MAPKAPK5	LUAD	chr12	112305409	112305409	A	G	Missense_Mutation	p.N74D	1
MAPKAPK5	HNSC	chr12	112323725	112323725	T	A	Missense_Mutation	p.L285Q	1
MAPKAPK5	PAAD	chr12	112326328	112326328	C	T	Nonsense_Mutation	p.Q336X	1
MAPKAPK5	LIHC	chr12	112327908	112327908	C	T	Silent	p.C429C	1
MAPKAPK5	THYM	chr12	112326727	112326727	A	G	Missense_Mutation	p.E380G	1
MAPKAPK5	COAD	chr12	112308895	112308895	C	T	Missense_Mutation	p.P164S	1
MAPKAPK5	LIHC	chr12	112308139	112308139	A	G	Missense_Mutation	p.N153S	1
MAPKAPK5	COAD	chr12	112318312	112318312	C	T	Missense_Mutation	p.T214M	1
MAPKAPK5	PAAD	chr12	112326328	112326328	C	T	Nonsense_Mutation		1
MAPKAPK5	BLCA	chr12	112303982	112303982	C	G	Missense_Mutation		1
MAPKAPK5	LIHC	chr12	112330837	112330837	A	T	Missense_Mutation	p.E465V	1
MAPKAPK5	UCEC	chr12	112306591	112306591	G	-	Frame_Shift_Del	p.G107fs	1
MAPKAPK5	COAD	chr12	112321467	112321467	G	A	Missense_Mutation	p.R248Q	1
MAPKAPK5	LUAD	chr12	112308955	112308955	C	G	Missense_Mutation	p.Q184E	1
MAPKAPK5	LGG	chr12	112327906	112327906	T	G	Missense_Mutation	p.C427G	1
MAPKAPK5	BLCA	chr12	112323737	112323737	C	T	Missense_Mutation		1
MAPKAPK5	COAD	chr12	112327900	112327900	C	T	Missense_Mutation	p.R427W	1
MAPKAPK5	LUSC	chr12	112318306	112318306	C	A	Nonsense_Mutation	p.S212*	1
MAPKAPK5	READ	chr12	112321565	112321565	G	A	Missense_Mutation	p.V281M	1

Copy number variation (CNV) of MAPKAPK5
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MAPKAPK5
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
97659	N/A	EC500789	ACAD10	chr12	112126491	+	MAPKAPK5	chr12	112329494	+
97659	N/A	EI790194	CDKL3	chr5	133685290	+	MAPKAPK5	chr12	112319509	-
97659	N/A	EC576418	CTCFL	chr20	56085863	-	MAPKAPK5	chr12	112297103	+
60891	N/A	DD229444	MAPKAPK5	chr12	112326688	-	ABHD12	chr20	25356322	+
101880	BRCA	TCGA-E2-A15J	MAPKAPK5	chr12	112308984	+	ACAD10	chr12	112182446	+
101880	Non-Cancer	TCGA-50-6595-11A	MAPKAPK5	chr12	112308984	+	ACAD10	chr12	112182447	+
101880	.	.	MAPKAPK5	chr12	112308888	+	ACAD10	chr12	112308888	+
90930	ACC	TCGA-OR-A5J7-01A	MAPKAPK5	chr12	112280573	+	ALDH2	chr12	112241663	+
90930	LUAD	TCGA-86-8054-01A	MAPKAPK5	chr12	112280573	+	ALDH2	chr12	112237710	+
90930	STAD	TCGA-BR-A452-01A	MAPKAPK5	chr12	112318331	+	ALDH2	chr12	112219722	+
90930	STAD	TCGA-BR-A452-01A	MAPKAPK5	chr12	112321572	+	ALDH2	chr12	112213409	+
98376	ESCA	TCGA-IG-A3I8	MAPKAPK5	chr12	112280573	+	ATXN2	chr12	111908546	-
60674	SARC	TCGA-3B-A9HO-01A	MAPKAPK5	chr12	112280573	+	CCDC38	chr12	96266238	-
103289	STAD	TCGA-VQ-A928	MAPKAPK5	chr12	112304035	+	ERP29	chr12	112457559	+
99799	BRCA	TCGA-BH-A18H-01A	MAPKAPK5	chr12	112304035	+	GNPTAB	chr12	102183835	-
97659	N/A	BE169498	MAPKAPK5	chr12	112326390	-	MAPKAPK5	chr12	112326778	+
97659	N/A	BP398174	MAPKAPK5	chr12	112334947	+	MAPKAPK5	chr12	112325382	+
97659	N/A	BP398708	MAPKAPK5	chr12	112326569	+	MAPKAPK5	chr12	112325382	+
97659	N/A	BU622192	MAPKAPK5	chr12	112326740	-	MAPKAPK5	chr12	112326336	+
89127	SARC	TCGA-PC-A5DN-01A	MAPKAPK5	chr12	112326422	+	PAWR	chr12	80007389	-
98411	LUAD	TCGA-38-4630-01A	MAPKAPK5	chr12	112280573	+	PTPN11	chr12	112884080	+
60081	READ	TCGA-AG-4015	MAPKAPK5	chr12	112308984	+	SMARCD1	chr12	50490633	+
93695	ESCA	TCGA-L5-A4OT	MAPKAPK5	chr12	112308984	+	TRAFD1	chr12	112568314	+
93695	ESCA	TCGA-L5-A4OT	MAPKAPK5	chr12	112308984	+	TRAFD1	chr12	112572541	+
93695	ESCA	TCGA-L5-A4OT	MAPKAPK5	chr12	112308984	+	TRAFD1	chr12	112572542	+
93695	ESCA	TCGA-L5-A4OT-01A	MAPKAPK5	chr12	112308984	+	TRAFD1	chr12	112568315	+
96797	SARC	TCGA-PC-A5DN-01A	MAPKAPK5	chr12	112326422	+	UNC119B	chr12	121157723	+
97659	N/A	BI495727	PIP4K2A	chr10	22843231	+	MAPKAPK5	chr12	112330967	-
97659	N/A	CA312732	ROMO1	chr20	34288845	-	MAPKAPK5	chr12	112331098	+
97659	OV	TCGA-24-2262-01A	USB1	chr16	58051343	+	MAPKAPK5	chr12	112308889	+
97670	PRAD	TCGA-HC-7818-01A	USP9X	chrX	40982977	-	MAPKAPK5	chr12	112303054	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	MAPKAPK5	0.00369149390593385	0.1
HNSC	MAPKAPK5	0.00619633300745546	0.16
PCPG	MAPKAPK5	0.019006879437834	0.48
GBM	MAPKAPK5	0.0227888887296728	0.55
PAAD	MAPKAPK5	0.043482972186586	1
LUAD	MAPKAPK5	4.29270872077794e-06	0.00012

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LAML	MAPKAPK5	0.0124544744606517	0.41
OV	MAPKAPK5	0.0181397009154547	0.58

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source