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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: DENR (NCBI Gene ID:8562)

Gene Summary

Gene Summary

Gene Information	Gene Name: DENR
	Gene ID: 8562
	Gene Symbol	DENR
	Gene ID	8562
	Gene Name	density regulated re-initiation and release factor
	Synonyms	DRP\|DRP1\|SMAP-3
	Cytomap	12q24.31
	Type of Gene	protein-coding
	Description	density-regulated proteinsmooth muscle cell associated protein-3
	Modification date	20200313
	UniProtAcc	O43583

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0002181	Cytoplasmic translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DENR	GO:0001731	formation of translation preinitiation complex	20713520
Hgene	DENR	GO:0032790	ribosome disassembly	20713520
Hgene	DENR	GO:0075522	IRES-dependent viral translational initiation	20713520

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
DENR	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'DENR[title] AND translation [title] AND human.'

Gene	Title	PMID
DENR	Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division	35115540

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000280557	123246733	123246753	Frame-shift
ENST00000280557	123252034	123252151	In-frame
ENST00000280557	123253328	123253468	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000280557	123252034	123252151	2786	482	598	198	98	137

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
O43583	98	137	2	198	Chain	ID=PRO_0000130600;Note=Density-regulated protein
O43583	98	137	115	182	Domain	Note=SUI1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00200

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
HNSC	DENR	1.63046611861477	0.00106627625814326

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KICH	DENR	0.060149408	0.025356168

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with DENR (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
TGCT	Cell metabolism gene	DENR	ATP5B	0.801392245	3.39E-36
TGCT	Cell metabolism gene	DENR	CCNC	0.808552945	2.69E-37
TGCT	Cell metabolism gene	DENR	NUP37	0.813785507	3.96E-38
TGCT	CGC	DENR	CCNC	0.808552945	2.69E-37
TGCT	TSG	DENR	CCNC	0.808552945	2.69E-37
UVM	Cell metabolism gene	DENR	ARFGEF2	0.800161148	5.39E-19
UVM	Cell metabolism gene	DENR	UGGT2	0.802040999	3.88E-19
UVM	Cell metabolism gene	DENR	RANBP2	0.802163395	3.79E-19
UVM	Cell metabolism gene	DENR	DLD	0.804126946	2.68E-19
UVM	Cell metabolism gene	DENR	SACM1L	0.805149696	2.23E-19
UVM	Cell metabolism gene	DENR	PPAT	0.806714814	1.68E-19
UVM	Cell metabolism gene	DENR	PSMD14	0.80690315	1.62E-19
UVM	Cell metabolism gene	DENR	MTMR6	0.80876499	1.16E-19
UVM	Cell metabolism gene	DENR	LCLAT1	0.808777119	1.15E-19
UVM	Cell metabolism gene	DENR	CMAS	0.809352433	1.04E-19
UVM	Cell metabolism gene	DENR	PIK3C3	0.810287	8.73E-20
UVM	Cell metabolism gene	DENR	VAPA	0.811153871	7.43E-20
UVM	Cell metabolism gene	DENR	GRPEL2	0.811760838	6.64E-20
UVM	Cell metabolism gene	DENR	CCT2	0.815654271	3.18E-20
UVM	Cell metabolism gene	DENR	SEH1L	0.817225422	2.35E-20
UVM	Cell metabolism gene	DENR	PSMC6	0.81761111	2.18E-20
UVM	Cell metabolism gene	DENR	PITPNB	0.817980561	2.03E-20
UVM	Cell metabolism gene	DENR	DIS3	0.819494316	1.51E-20
UVM	Cell metabolism gene	DENR	NUPL2	0.820539526	1.23E-20
UVM	Cell metabolism gene	DENR	PRKAA1	0.821390521	1.04E-20
UVM	Cell metabolism gene	DENR	PHAX	0.824326041	5.79E-21
UVM	Cell metabolism gene	DENR	MINPP1	0.829136383	2.16E-21
UVM	Cell metabolism gene	DENR	RAP1B	0.833189437	9.19E-22
UVM	Cell metabolism gene	DENR	TNPO1	0.836971388	4.05E-22
UVM	Cell metabolism gene	DENR	XPO1	0.850884273	1.65E-23
UVM	Cell metabolism gene	DENR	NUP107	0.86812627	1.93E-25
UVM	Cell metabolism gene	DENR	NUP50	0.880986526	4.54E-27
UVM	CGC	DENR	USP8	0.80032032	5.25E-19
UVM	CGC	DENR	KDM5A	0.80181677	4.03E-19
UVM	CGC	DENR	RANBP2	0.802163395	3.79E-19
UVM	CGC	DENR	RAD17	0.804870532	2.34E-19
UVM	CGC	DENR	KIF5B	0.808639743	1.18E-19
UVM	CGC	DENR	NFE2L2	0.809258334	1.06E-19
UVM	CGC	DENR	FBXO11	0.809440352	1.02E-19
UVM	CGC	DENR	SUZ12	0.812412891	5.87E-20
UVM	CGC	DENR	ZMYM2	0.81421848	4.18E-20
UVM	CGC	DENR	ATF1	0.814478722	3.98E-20
UVM	CGC	DENR	BAZ1A	0.814504726	3.96E-20
UVM	CGC	DENR	DDX5	0.8174106	2.27E-20
UVM	CGC	DENR	HSP90AA1	0.820504285	1.24E-20
UVM	CGC	DENR	TOP1	0.831511196	1.31E-21
UVM	CGC	DENR	PMS1	0.832983691	9.60E-22
UVM	CGC	DENR	POT1	0.833554492	8.50E-22
UVM	CGC	DENR	RABEP1	0.841083924	1.63E-22
UVM	CGC	DENR	GOLGA5	0.841789802	1.39E-22
UVM	CGC	DENR	ARID2	0.844102494	8.17E-23
UVM	CGC	DENR	XPO1	0.850884273	1.65E-23
UVM	CGC	DENR	ATM	0.851431072	1.45E-23
UVM	Epifactor	DENR	KDM5A	0.80181677	4.03E-19
UVM	Epifactor	DENR	USP15	0.806929341	1.62E-19
UVM	Epifactor	DENR	SMEK1	0.811909219	6.45E-20
UVM	Epifactor	DENR	SUZ12	0.812412891	5.87E-20
UVM	Epifactor	DENR	JMJD1C	0.813537857	4.75E-20
UVM	Epifactor	DENR	SENP1	0.813775025	4.54E-20
UVM	Epifactor	DENR	ZMYM2	0.81421848	4.18E-20
UVM	Epifactor	DENR	BAZ1A	0.814504726	3.96E-20
UVM	Epifactor	DENR	CHUK	0.814796528	3.74E-20
UVM	Epifactor	DENR	HAT1	0.818747699	1.75E-20
UVM	Epifactor	DENR	PRKAA1	0.821390521	1.04E-20
UVM	Epifactor	DENR	FAM175B	0.828006716	2.73E-21
UVM	Epifactor	DENR	CDK17	0.828450618	2.49E-21
UVM	Epifactor	DENR	CUL2	0.829159911	2.15E-21
UVM	Epifactor	DENR	PARG	0.830114142	1.76E-21
UVM	Epifactor	DENR	TAF7	0.834035037	7.66E-22
UVM	Epifactor	DENR	TLK1	0.836969636	4.05E-22
UVM	Epifactor	DENR	AEBP2	0.840725355	1.76E-22
UVM	Epifactor	DENR	ARID2	0.844102494	8.17E-23
UVM	Epifactor	DENR	ZRANB3	0.845986493	5.28E-23
UVM	Epifactor	DENR	SMEK2	0.848852441	2.69E-23
UVM	Epifactor	DENR	ATM	0.851431072	1.45E-23
UVM	Epifactor	DENR	ACTR6	0.866628529	2.91E-25
UVM	Epifactor	DENR	TDG	0.87363697	4.07E-26
UVM	IUPHAR	DENR	RIOK3	0.800673989	4.93E-19
UVM	IUPHAR	DENR	KDM5A	0.80181677	4.03E-19
UVM	IUPHAR	DENR	TAOK3	0.803565623	2.96E-19
UVM	IUPHAR	DENR	RIOK2	0.806681343	1.69E-19
UVM	IUPHAR	DENR	PPAT	0.806714814	1.68E-19
UVM	IUPHAR	DENR	PSMD14	0.80690315	1.62E-19
UVM	IUPHAR	DENR	MAP4K3	0.807021747	1.59E-19
UVM	IUPHAR	DENR	NFE2L2	0.809258334	1.06E-19
UVM	IUPHAR	DENR	FBXO11	0.809440352	1.02E-19
UVM	IUPHAR	DENR	PIK3C3	0.810287	8.73E-20
UVM	IUPHAR	DENR	XIAP	0.811925909	6.43E-20
UVM	IUPHAR	DENR	TNKS2	0.812512242	5.77E-20
UVM	IUPHAR	DENR	JMJD1C	0.813537857	4.75E-20
UVM	IUPHAR	DENR	SENP1	0.813775025	4.54E-20
UVM	IUPHAR	DENR	ATP2B1	0.813918943	4.42E-20
UVM	IUPHAR	DENR	BAZ1A	0.814504726	3.96E-20
UVM	IUPHAR	DENR	MARK3	0.814670249	3.84E-20
UVM	IUPHAR	DENR	CHUK	0.814796528	3.74E-20
UVM	IUPHAR	DENR	NAPEPLD	0.818155553	1.96E-20
UVM	IUPHAR	DENR	HAT1	0.818747699	1.75E-20
UVM	IUPHAR	DENR	CSNK1G3	0.820165361	1.33E-20
UVM	IUPHAR	DENR	HSP90AA1	0.820504285	1.24E-20
UVM	IUPHAR	DENR	ADAM17	0.821048013	1.11E-20
UVM	IUPHAR	DENR	PRKAA1	0.821390521	1.04E-20
UVM	IUPHAR	DENR	PLK4	0.823815856	6.41E-21
UVM	IUPHAR	DENR	CDK17	0.828450618	2.49E-21
UVM	IUPHAR	DENR	TOP1	0.831511196	1.31E-21
UVM	IUPHAR	DENR	TLK1	0.836969636	4.05E-22
UVM	IUPHAR	DENR	CSNK1A1	0.840767649	1.74E-22
UVM	IUPHAR	DENR	ATP6V0A2	0.842175157	1.27E-22
UVM	IUPHAR	DENR	PRMT3	0.847521713	3.68E-23
UVM	IUPHAR	DENR	XPO1	0.850884273	1.65E-23
UVM	IUPHAR	DENR	ATM	0.851431072	1.45E-23
UVM	IUPHAR	DENR	TBK1	0.857968032	2.85E-24
UVM	IUPHAR	DENR	USP14	0.861412624	1.17E-24
UVM	Kinase	DENR	RIOK3	0.800673989	4.93E-19
UVM	Kinase	DENR	TAOK3	0.803565623	2.96E-19
UVM	Kinase	DENR	RIOK2	0.806681343	1.69E-19
UVM	Kinase	DENR	MAP4K3	0.807021747	1.59E-19
UVM	Kinase	DENR	BAZ1A	0.814504726	3.96E-20
UVM	Kinase	DENR	MARK3	0.814670249	3.84E-20
UVM	Kinase	DENR	CHUK	0.814796528	3.74E-20
UVM	Kinase	DENR	CSNK1G3	0.820165361	1.33E-20
UVM	Kinase	DENR	PRKAA1	0.821390521	1.04E-20
UVM	Kinase	DENR	PLK4	0.823815856	6.41E-21
UVM	Kinase	DENR	CDK17	0.828450618	2.49E-21
UVM	Kinase	DENR	TLK1	0.836969636	4.05E-22
UVM	Kinase	DENR	CSNK1A1	0.840767649	1.74E-22
UVM	Kinase	DENR	ATM	0.851431072	1.45E-23
UVM	Kinase	DENR	TBK1	0.857968032	2.85E-24
UVM	TF	DENR	ZNF136	0.805162124	2.22E-19
UVM	TF	DENR	ZNF43	0.805726294	2.01E-19
UVM	TF	DENR	ZNF268	0.808547818	1.20E-19
UVM	TF	DENR	ZNF28	0.808757864	1.16E-19
UVM	TF	DENR	NFE2L2	0.809258334	1.06E-19
UVM	TF	DENR	ZNF800	0.809801576	9.55E-20
UVM	TF	DENR	ZBTB1	0.812222619	6.09E-20
UVM	TF	DENR	SMAD5	0.813285407	4.98E-20
UVM	TF	DENR	ATF1	0.814478722	3.98E-20
UVM	TF	DENR	ZNF146	0.817385676	2.28E-20
UVM	TF	DENR	ZNF181	0.818581565	1.81E-20
UVM	TF	DENR	FOXN2	0.820424957	1.26E-20
UVM	TF	DENR	ZNF131	0.831635299	1.28E-21
UVM	TF	DENR	GPBP1	0.836308065	4.69E-22
UVM	TF	DENR	PURB	0.836981889	4.04E-22
UVM	TF	DENR	ZNF26	0.839238192	2.46E-22
UVM	TF	DENR	AEBP2	0.840725355	1.76E-22
UVM	TF	DENR	ARID2	0.844102494	8.17E-23
UVM	TF	DENR	ZNF140	0.845987745	5.28E-23
UVM	TF	DENR	PRMT3	0.847521713	3.68E-23
UVM	TF	DENR	CEBPZ	0.855838231	4.88E-24
UVM	TSG	DENR	KDM5A	0.80181677	4.03E-19
UVM	TSG	DENR	GORAB	0.810706334	8.08E-20
UVM	TSG	DENR	SUZ12	0.812412891	5.87E-20
UVM	TSG	DENR	CHUK	0.814796528	3.74E-20
UVM	TSG	DENR	KRIT1	0.817260889	2.33E-20
UVM	TSG	DENR	NAPEPLD	0.818155553	1.96E-20
UVM	TSG	DENR	PRKAA1	0.821390521	1.04E-20
UVM	TSG	DENR	DCLRE1A	0.823870869	6.34E-21
UVM	TSG	DENR	GGNBP2	0.825790358	4.30E-21
UVM	TSG	DENR	MLH3	0.828631765	2.40E-21
UVM	TSG	DENR	CUL2	0.829159911	2.15E-21
UVM	TSG	DENR	APAF1	0.834428794	7.04E-22
UVM	TSG	DENR	RBBP8	0.840762619	1.75E-22
UVM	TSG	DENR	CSNK1A1	0.840767649	1.74E-22
UVM	TSG	DENR	ARID2	0.844102494	8.17E-23
UVM	TSG	DENR	SMCHD1	0.844268271	7.87E-23
UVM	TSG	DENR	RINT1	0.844408166	7.62E-23
UVM	TSG	DENR	ATM	0.851431072	1.45E-23
UVM	TSG	DENR	GTPBP4	0.869683075	1.25E-25

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	DENR	RPS27A	1.75396693785956	0.000187873840332031
STAD	DENR	FIS1	1.59734007916803	0.000213860534131527
KICH	DENR	MFF	-6.66754838105809	0.000808119773864746
PRAD	DENR	RPS15	2.38682220239643	0.000931746432967977
KIRP	DENR	RPS11	-1.01861570565103	0.00105937570333481
KIRP	DENR	MFF	-2.64349658310315	0.00133262807503343
LUSC	DENR	RPS15	-1.54018132537089	0.00665527288479679
CHOL	DENR	FIS1	-6.06067740385036	0.0078125
THCA	DENR	FAU	1.18509450470262	0.0152379297688856
BLCA	DENR	RPS27A	-1.04747470069188	0.0258216857910156
KIRP	DENR	FAU	-1.04355048353271	0.0309218638576567
COAD	DENR	RPS11	1.35307548998204	0.0312207043170929
HNSC	DENR	RPS25	2.24439018636525	1.07420805761649e-06
KIRC	DENR	FAU	-2.50135425883801	1.33253564327251e-08
THCA	DENR	RPS2	-2.9749691422722	1.8399565126656e-05
KIRC	DENR	RPS2	-3.31623058345719	2.17100738110179e-12
KICH	DENR	MCTS1	-2.5074280800957	2.98023223876953e-07
KIRC	DENR	MFF	-4.86877288693613	4.25761914751048e-08
KIRP	DENR	RPS2	-2.72788021566791	5.12227416038514e-08
LUAD	DENR	MFF	-1.2722697620092	6.08141713132516e-09
LUAD	DENR	RPS2	-2.88992098496468	6.51132046672323e-08
KIRC	DENR	RPS15	-1.51134139657827	6.64395189280361e-09
LUSC	DENR	MCTS1	-2.41801915956715	7.28442422628201e-06
BRCA	DENR	RPS27A	-4.28512148200424	7.8788217967112e-14
LUSC	DENR	MFF	-1.96008146156819	8.09518720669431e-05
KICH	DENR	RPS2	-4.73426315307469	8.34465026855468e-07
LIHC	DENR	MFF	-1.6399016753561	8.88318924444854e-05
KIRP	DENR	RPS15	-1.53644743209735	9.0546440333128e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with DENR

MCTS1, ELAVL1, DMAP1, NLRX1, XRCC4, EEF2K, NELFB, HMGB3, HNRNPA2B1, HNRNPD, PPP1CB, RPL10, UBXN1, FSD1, NFKBIA, NUDT6, OXNAD1, RWDD2B, SLC25A32, TALDO1, CDK5R1, EIF2D, EWSR1, XPO1, DUSP5, DOCK11, NTMT1, RB1CC1, ATG13, COPS5, DHTKD1, NSUN4, SNRNP27, COPS2, AMZ2, FGB, PDLIM5, COPS7A, USP47, COPS4, VDAC2, COPS6, BTBD1, COPS7B, CHGA, PDK1, MAPT, TMA20, TNIP2, RECQL4, HIST1H4A, HIST1H2BB, ATG16L1, RBX1, KRAS, PLEKHA4, ENG, HCVgp1, N, PRNP, Apc2, COPS3,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
DENR	chr12	123246725	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
DENR	BLCA	chr12	123253605	123253605	C	A	Missense_Mutation	p.L193I	2
DENR	BLCA	chr12	123253411	123253411	C	T	Silent	p.I165I	2
DENR	UCEC	chr12	123249868	123249868	G	T	Nonsense_Mutation	p.E77*	2
DENR	UCEC	chr12	123252140	123252140	T	C	Missense_Mutation	p.L134P	2
DENR	KIRP	chr12	123253468	123253468	G	-	Frame_Shift_Del	p.E184fs	2
DENR	UCEC	chr12	123253441	123253441	T	C	Silent	p.I175	2
DENR	KIRP	chr12	123253468	123253468	G	-	Splice_Site	p.E184_splice	2
DENR	SKCM	chr12	123238315	123238315	T	C	Silent	p.L23L	2
DENR	BLCA	chr12	123253605	123253605	C	A	Missense_Mutation		1
DENR	SKCM	chr12	123253443	123253443	A	C	Missense_Mutation	p.D176A	1
DENR	BLCA	chr12	123238274	123238274	G	T	Missense_Mutation		1
DENR	SKCM	chr12	123252104	123252104	G	A	Missense_Mutation	p.R122K	1
DENR	SKCM	chr12	123253374	123253374	C	T	Missense_Mutation	p.S153F	1
DENR	SKCM	chr12	123238271	123238271	C	T	Missense_Mutation	p.S8F	1
DENR	BLCA	chr12	123238274	123238274	G	T	Missense_Mutation	p.S9I	1
DENR	SKCM	chr12	123253445	123253445	G	A	Missense_Mutation	p.V177I	1
DENR	COAD	chr12	123252056	123252056	A	-	Frame_Shift_Del	p.Q106fs	1
DENR	KIRC	chr12	123238330	123238330	C	G	Missense_Mutation	p.P28A	1
DENR	READ	chr12	123238336	123238336	C	T	Nonsense_Mutation	p.R30X	1

Copy number variation (CNV) of DENR
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across DENR
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101242	N/A	T35084	CD99L2	chrX	149936353	-	DENR	chr12	123254604	+
94594	N/A	BF222617	DENR	chr12	123249924	+	BCL2L2-PABPN1	chr14	23794510	+
59527	N/A	BE813357	DENR	chr12	123254339	-	CMBL	chr5	10279956	+
90132	BLCA	TCGA-FD-A6TG-01A	DENR	chr12	123252151	+	KNTC1	chr12	123087116	+
90132	LUAD	TCGA-50-5946-01A	DENR	chr12	123249934	+	KNTC1	chr12	123078823	+
97882	N/A	BF923604	DENR	chr12	123254534	+	RAB31	chr18	9775283	+
101242	UCEC	TCGA-BK-A26L-01A	HIP1R	chr12	123320187	+	DENR	chr12	123238237	+
101242	UCEC	TCGA-BK-A26L-01C	HIP1R	chr12	123320191	+	DENR	chr12	123238241	+
101242	N/A	BC012148	KDM1B	chr6	18205961	+	DENR	chr12	123254301	+
101242	STAD	TCGA-CD-8531-01A	LAPTM4A	chr2	20251171	-	DENR	chr12	123238240	+
101242	ACC	TCGA-OR-A5JP-01A	PEG3	chr19	57347438	-	DENR	chr12	123252135	+
101242	SARC	TCGA-DX-AB2O-01A	RNF10	chr12	120990501	+	DENR	chr12	123238240	+
101242	N/A	AI357654	ZBTB20	chr3	114056777	+	DENR	chr12	123255608	-
101246	ACC	TCGA-OR-A5JP-01A	ZIM2	chr19	57347438	-	DENR	chr12	123252135	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	DENR	0.00594452729780994	0.17
KIRC	DENR	0.00785101080533661	0.21
TGCT	DENR	0.0108365200967807	0.28

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KICH	DENR	0.0288636256867332	0.92
OV	DENR	0.0346037563952838	1
ESCA	DENR	0.0152233157060184	0.5

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source